ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.95204043
2	viral transcription (GO:0019083)	5.39146127
3	translational termination (GO:0006415)	5.29087162
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.80347757
5	translational elongation (GO:0006414)	4.77105054
6	cotranslational protein targeting to membrane (GO:0006613)	4.73552360
7	protein targeting to ER (GO:0045047)	4.71626907
8	ribosomal small subunit biogenesis (GO:0042274)	4.70819541
9	DNA deamination (GO:0045006)	4.64980679
10	water-soluble vitamin biosynthetic process (GO:0042364)	4.58640705
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.58365846
12	ATP synthesis coupled proton transport (GO:0015986)	4.58365846
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.57055540
14	protein localization to endoplasmic reticulum (GO:0070972)	4.46068438
15	maturation of SSU-rRNA (GO:0030490)	4.39004000
16	ribosomal large subunit biogenesis (GO:0042273)	4.22849482
17	GTP biosynthetic process (GO:0006183)	4.20773156
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.10880815
19	protein neddylation (GO:0045116)	4.07787537
20	rRNA modification (GO:0000154)	4.05659954
21	response to gravity (GO:0009629)	4.02492461
22	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.94110188
23	viral life cycle (GO:0019058)	3.93748525
24	protein complex biogenesis (GO:0070271)	3.85627840
25	cellular protein complex disassembly (GO:0043624)	3.81799716
26	rRNA methylation (GO:0031167)	3.80559114
27	chaperone-mediated protein transport (GO:0072321)	3.80423918
28	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.75454324
29	UTP biosynthetic process (GO:0006228)	3.70117577
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.67096958
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.65444296
32	translational initiation (GO:0006413)	3.64957157
33	UTP metabolic process (GO:0046051)	3.64079979
34	preassembly of GPI anchor in ER membrane (GO:0016254)	3.62296382
35	NADH dehydrogenase complex assembly (GO:0010257)	3.61104124
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.61104124
37	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.61104124
38	behavioral response to nicotine (GO:0035095)	3.58413549
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.55279949
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.54051025
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.53970005
42	translation (GO:0006412)	3.53738407
43	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.48069026
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.45645138
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.45645138
46	respiratory chain complex IV assembly (GO:0008535)	3.42510545
47	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.42135797
48	cellular ketone body metabolic process (GO:0046950)	3.41717665
49	protein polyglutamylation (GO:0018095)	3.36663406
50	myoblast migration (GO:0051451)	3.33338314
51	cellular component biogenesis (GO:0044085)	3.30323385
52	protein K6-linked ubiquitination (GO:0085020)	3.25396997
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.24390231
54	ribonucleoprotein complex biogenesis (GO:0022613)	3.22504419
55	CTP metabolic process (GO:0046036)	3.17608919
56	CTP biosynthetic process (GO:0006241)	3.17608919
57	protein complex disassembly (GO:0043241)	3.15329330
58	electron transport chain (GO:0022900)	3.13715669
59	fucose catabolic process (GO:0019317)	3.12816374
60	L-fucose metabolic process (GO:0042354)	3.12816374
61	L-fucose catabolic process (GO:0042355)	3.12816374
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.11339002
63	respiratory electron transport chain (GO:0022904)	3.10752522
64	ubiquinone biosynthetic process (GO:0006744)	3.09691993
65	protein targeting to membrane (GO:0006612)	3.05273942
66	cytochrome complex assembly (GO:0017004)	3.02497111
67	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.00891952
68	macromolecular complex disassembly (GO:0032984)	3.00838387
69	cullin deneddylation (GO:0010388)	2.99417750
70	ketone body metabolic process (GO:1902224)	2.99029629
71	inositol phosphate dephosphorylation (GO:0046855)	2.98564645
72	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.98564645
73	tRNA processing (GO:0008033)	2.98402618
74	platelet dense granule organization (GO:0060155)	2.98209360
75	DNA damage response, detection of DNA damage (GO:0042769)	2.96016714
76	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.95293516
77	rRNA processing (GO:0006364)	2.95055912
78	adult feeding behavior (GO:0008343)	2.92784204
79	proteasome assembly (GO:0043248)	2.89325990
80	rRNA metabolic process (GO:0016072)	2.87389485
81	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.86755681
82	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.86694393
83	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.86483692
84	protein deneddylation (GO:0000338)	2.82972597
85	regulation of immunoglobulin secretion (GO:0051023)	2.82879902
86	regulation of isotype switching to IgG isotypes (GO:0048302)	2.81450689
87	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.80786746
88	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.79987044
89	mRNA catabolic process (GO:0006402)	2.78537516
90	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.78056830
91	nucleoside diphosphate phosphorylation (GO:0006165)	2.77794977
92	ATP biosynthetic process (GO:0006754)	2.76780848
93	ubiquinone metabolic process (GO:0006743)	2.74290361
94	hypothalamus development (GO:0021854)	2.73893992
95	inositol phosphate catabolic process (GO:0071545)	2.72481589
96	nephron epithelium morphogenesis (GO:0072088)	2.69640542
97	nephron tubule morphogenesis (GO:0072078)	2.69640542
98	regulation of cilium movement (GO:0003352)	2.69624706
99	regulation of regulatory T cell differentiation (GO:0045589)	2.66095358
100	C-terminal protein lipidation (GO:0006501)	2.64886636

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.17704702
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65524243
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.62214405
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.54771809
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.47459311
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.34369378
7	VDR_22108803_ChIP-Seq_LS180_Human	3.21484803
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.80823565
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.74195663
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.61930288
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44912703
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.40769747
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.26677618
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.12714740
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.08511255
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.05493825
17	FUS_26573619_Chip-Seq_HEK293_Human	2.03854074
18	EWS_26573619_Chip-Seq_HEK293_Human	1.99836909
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.98845369
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.94680821
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91914736
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.89452809
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84834851
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84046699
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.74932602
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.70308717
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63880061
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.61476959
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.61260619
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.58898720
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.58496599
32	P300_19829295_ChIP-Seq_ESCs_Human	1.55131301
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52074168
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50734188
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50218102
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48376873
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43315878
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42511145
39	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40955985
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39453193
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.34675525
42	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.32689235
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.32419651
44	IGF1R_20145208_ChIP-Seq_DFB_Human	1.30528888
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.26803543
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.25302894
47	NCOR_22424771_ChIP-Seq_293T_Human	1.23611657
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21442967
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21442967
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20451146
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20226397
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18637610
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18637610
54	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.18245091
55	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.17635911
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16050433
57	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.15257711
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.15158289
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14015576
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13894160
61	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13470539
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13223886
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10041597
64	AR_20517297_ChIP-Seq_VCAP_Human	1.09473200
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09238598
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.09134179
67	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.09088317
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08798790
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07788776
70	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.07069732
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06599045
72	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.05982452
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05028776
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05008801
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.04013456
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03819728
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.01910009
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.00322472
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00322472
80	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99039249
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.98891900
82	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97982493
83	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96892201
84	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.95750334
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.95624520
86	DCP1A_22483619_ChIP-Seq_HELA_Human	0.94374951
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93941689
88	XRN2_22483619_ChIP-Seq_HELA_Human	0.93278928
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93145013
90	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92344797
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90892763
92	ERA_21632823_ChIP-Seq_H3396_Human	0.90716446
93	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90246095
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89418794
95	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.89411887
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87432181
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87230414
98	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.87188170
99	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.85971317
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.85650169

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.23148615
2	MP0008877_abnormal_DNA_methylation	4.23021342
3	MP0009379_abnormal_foot_pigmentation	3.36507072
4	MP0002138_abnormal_hepatobiliary_system	3.11072119
5	MP0003787_abnormal_imprinting	2.64853086
6	MP0002102_abnormal_ear_morphology	2.47318039
7	MP0004145_abnormal_muscle_electrophysio	2.29484587
8	MP0000569_abnormal_digit_pigmentation	2.25318907
9	MP0005377_hearing/vestibular/ear_phenot	2.11710790
10	MP0003878_abnormal_ear_physiology	2.11710790
11	MP0003011_delayed_dark_adaptation	2.07677945
12	MP0001348_abnormal_lacrimal_gland	2.02979134
13	MP0004147_increased_porphyrin_level	2.01941754
14	MP0004142_abnormal_muscle_tone	1.99465848
15	MP0004885_abnormal_endolymph	1.95895010
16	MP0003121_genomic_imprinting	1.92199082
17	MP0001293_anophthalmia	1.91622193
18	MP0006072_abnormal_retinal_apoptosis	1.79897707
19	MP0003123_paternal_imprinting	1.77551605
20	MP0002736_abnormal_nociception_after	1.77332064
21	MP0003195_calcinosis	1.69694940
22	MP0008789_abnormal_olfactory_epithelium	1.68231714
23	MP0001968_abnormal_touch/_nociception	1.67422031
24	MP0005379_endocrine/exocrine_gland_phen	1.61464150
25	MP0005551_abnormal_eye_electrophysiolog	1.61315786
26	MP0003646_muscle_fatigue	1.59769059
27	MP0002837_dystrophic_cardiac_calcinosis	1.59063765
28	MP0001984_abnormal_olfaction	1.57698606
29	MP0002163_abnormal_gland_morphology	1.53909930
30	MP0001661_extended_life_span	1.53771636
31	MP0005646_abnormal_pituitary_gland	1.53207365
32	MP0003122_maternal_imprinting	1.49925159
33	MP0000372_irregular_coat_pigmentation	1.49833323
34	MP0005253_abnormal_eye_physiology	1.49053653
35	MP0008872_abnormal_physiological_respon	1.45632735
36	MP0005084_abnormal_gallbladder_morpholo	1.45573749
37	MP0005645_abnormal_hypothalamus_physiol	1.44602470
38	MP0008875_abnormal_xenobiotic_pharmacok	1.40994288
39	MP0002876_abnormal_thyroid_physiology	1.38005393
40	MP0010030_abnormal_orbit_morphology	1.32308038
41	MP0003806_abnormal_nucleotide_metabolis	1.32286464
42	MP0006276_abnormal_autonomic_nervous	1.30498752
43	MP0002272_abnormal_nervous_system	1.27681310
44	MP0000631_abnormal_neuroendocrine_gland	1.27394334
45	MP0000427_abnormal_hair_cycle	1.26722870
46	MP0001501_abnormal_sleep_pattern	1.24358771
47	MP0009046_muscle_twitch	1.23890681
48	MP0003786_premature_aging	1.19694609
49	MP0001986_abnormal_taste_sensitivity	1.19293453
50	MP0002095_abnormal_skin_pigmentation	1.15173159
51	MP0003937_abnormal_limbs/digits/tail_de	1.14144819
52	MP0001485_abnormal_pinna_reflex	1.12503325
53	MP0009780_abnormal_chondrocyte_physiolo	1.10930100
54	MP0005671_abnormal_response_to	1.07024885
55	MP0005389_reproductive_system_phenotype	1.05113380
56	MP0002733_abnormal_thermal_nociception	1.00061998
57	MP0001970_abnormal_pain_threshold	1.00005566
58	MP0004742_abnormal_vestibular_system	0.98263655
59	MP0002938_white_spotting	0.96197655
60	MP0000613_abnormal_salivary_gland	0.96135538
61	MP0001764_abnormal_homeostasis	0.95225693
62	MP0001905_abnormal_dopamine_level	0.91799024
63	MP0001919_abnormal_reproductive_system	0.91660591
64	MP0000049_abnormal_middle_ear	0.90643576
65	MP0002089_abnormal_postnatal_growth/wei	0.90140144
66	MP0003693_abnormal_embryo_hatching	0.87511653
67	MP0009745_abnormal_behavioral_response	0.86448094
68	MP0002638_abnormal_pupillary_reflex	0.85133613
69	MP0003186_abnormal_redox_activity	0.84757552
70	MP0003718_maternal_effect	0.84748813
71	MP0000230_abnormal_systemic_arterial	0.84534212
72	MP0000026_abnormal_inner_ear	0.82525949
73	MP0005174_abnormal_tail_pigmentation	0.81259530
74	MP0003959_abnormal_lean_body	0.81074386
75	MP0003936_abnormal_reproductive_system	0.80166307
76	MP0008995_early_reproductive_senescence	0.79887311
77	MP0005499_abnormal_olfactory_system	0.79761892
78	MP0005394_taste/olfaction_phenotype	0.79761892
79	MP0002160_abnormal_reproductive_system	0.79505863
80	MP0001486_abnormal_startle_reflex	0.78183400
81	MP0009764_decreased_sensitivity_to	0.77911175
82	MP0001835_abnormal_antigen_presentation	0.77910959
83	MP0005670_abnormal_white_adipose	0.76478780
84	MP0009250_abnormal_appendicular_skeleto	0.75910782
85	MP0001440_abnormal_grooming_behavior	0.75400289
86	MP0005391_vision/eye_phenotype	0.74688775
87	MP0005075_abnormal_melanosome_morpholog	0.73562380
88	MP0005195_abnormal_posterior_eye	0.73481767
89	MP0001529_abnormal_vocalization	0.73370861
90	MP0004133_heterotaxia	0.73115110
91	MP0005083_abnormal_biliary_tract	0.71625761
92	MP0000604_amyloidosis	0.70634895
93	MP0002210_abnormal_sex_determination	0.70305453
94	MP0005636_abnormal_mineral_homeostasis	0.69965811
95	MP0002277_abnormal_respiratory_mucosa	0.69591019
96	MP0001963_abnormal_hearing_physiology	0.69430762
97	MP0002184_abnormal_innervation	0.67772884
98	MP0002557_abnormal_social/conspecific_i	0.67086695
99	MP0002693_abnormal_pancreas_physiology	0.66236556
100	MP0003880_abnormal_central_pattern	0.65495835

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.24869899
2	Molar tooth sign on MRI (HP:0002419)	3.98827748
3	Abnormality of midbrain morphology (HP:0002418)	3.98827748
4	Mitochondrial inheritance (HP:0001427)	3.76084931
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.72831794
6	Acute encephalopathy (HP:0006846)	3.63655815
7	Progressive macrocephaly (HP:0004481)	3.62737812
8	Increased CSF lactate (HP:0002490)	3.46451719
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.38550286
10	Hypomagnesemia (HP:0002917)	3.37051193
11	Nephronophthisis (HP:0000090)	3.32009686
12	Pancreatic fibrosis (HP:0100732)	3.27678585
13	Pancreatic cysts (HP:0001737)	3.11684382
14	Reticulocytopenia (HP:0001896)	3.07976201
15	Abnormality of magnesium homeostasis (HP:0004921)	2.94779113
16	Methylmalonic acidemia (HP:0002912)	2.92823280
17	Hepatocellular necrosis (HP:0001404)	2.86068436
18	Increased hepatocellular lipid droplets (HP:0006565)	2.82202243
19	Hepatic necrosis (HP:0002605)	2.76815671
20	Abnormality of the renal medulla (HP:0100957)	2.76484403
21	Lipid accumulation in hepatocytes (HP:0006561)	2.71489347
22	Macrocytic anemia (HP:0001972)	2.70110505
23	Chronic hepatic failure (HP:0100626)	2.69829720
24	Cerebral edema (HP:0002181)	2.69020338
25	True hermaphroditism (HP:0010459)	2.66174079
26	Mesomelia (HP:0003027)	2.62486207
27	Abnormality of the pons (HP:0007361)	2.61964973
28	Stenosis of the external auditory canal (HP:0000402)	2.60659817
29	Hypoplasia of the pons (HP:0012110)	2.59600703
30	Congenital stationary night blindness (HP:0007642)	2.58690454
31	Abolished electroretinogram (ERG) (HP:0000550)	2.58130683
32	Abnormal number of erythroid precursors (HP:0012131)	2.54818588
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.53787430
34	Asplenia (HP:0001746)	2.52935585
35	Optic disc pallor (HP:0000543)	2.52396474
36	Stomatitis (HP:0010280)	2.51971224
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.46984671
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.37824308
39	Palpebral edema (HP:0100540)	2.34581625
40	Increased serum lactate (HP:0002151)	2.33639509
41	3-Methylglutaconic aciduria (HP:0003535)	2.30896748
42	Methylmalonic aciduria (HP:0012120)	2.26644718
43	Absent thumb (HP:0009777)	2.25880226
44	Pendular nystagmus (HP:0012043)	2.25362505
45	Congenital, generalized hypertrichosis (HP:0004540)	2.23700096
46	Lactic acidosis (HP:0003128)	2.21966470
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18397305
48	Medial flaring of the eyebrow (HP:0010747)	2.12634584
49	Increased intramyocellular lipid droplets (HP:0012240)	2.11304084
50	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.10605249
51	Septo-optic dysplasia (HP:0100842)	2.09619619
52	Renal Fanconi syndrome (HP:0001994)	2.09458071
53	Sclerocornea (HP:0000647)	2.06206664
54	Abnormality of the renal cortex (HP:0011035)	2.02879246
55	Exertional dyspnea (HP:0002875)	2.02368310
56	Constricted visual fields (HP:0001133)	2.01100789
57	Increased corneal curvature (HP:0100692)	1.98971415
58	Keratoconus (HP:0000563)	1.98971415
59	Progressive microcephaly (HP:0000253)	1.98004551
60	Postaxial foot polydactyly (HP:0001830)	1.96829628
61	Hyperglycinemia (HP:0002154)	1.95117235
62	Adrenal hypoplasia (HP:0000835)	1.95089343
63	Exercise intolerance (HP:0003546)	1.94664736
64	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.94567902
65	Abnormality of vitamin B metabolism (HP:0004340)	1.93561041
66	Polydipsia (HP:0001959)	1.92728966
67	Abnormal drinking behavior (HP:0030082)	1.92728966
68	Ketosis (HP:0001946)	1.90200370
69	Lethargy (HP:0001254)	1.88576350
70	Type 2 muscle fiber atrophy (HP:0003554)	1.87958157
71	Broad alveolar ridges (HP:0000187)	1.87039953
72	Rib fusion (HP:0000902)	1.85856043
73	Anencephaly (HP:0002323)	1.85713055
74	Optic nerve coloboma (HP:0000588)	1.84752776
75	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.84557202
76	Abnormal biliary tract physiology (HP:0012439)	1.80970997
77	Bile duct proliferation (HP:0001408)	1.80970997
78	Broad-based gait (HP:0002136)	1.80394057
79	Large for gestational age (HP:0001520)	1.78990405
80	Chorioretinal atrophy (HP:0000533)	1.78590405
81	Respiratory failure (HP:0002878)	1.78325795
82	Glycosuria (HP:0003076)	1.78283492
83	Abnormality of urine glucose concentration (HP:0011016)	1.78283492
84	Absent phalangeal crease (HP:0006109)	1.77519692
85	Abnormal ciliary motility (HP:0012262)	1.75640506
86	Erythroderma (HP:0001019)	1.74371364
87	Polyuria (HP:0000103)	1.74101475
88	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.74046850
89	Oligomenorrhea (HP:0000876)	1.73499931
90	Retinal dysplasia (HP:0007973)	1.72607595
91	Congenital hepatic fibrosis (HP:0002612)	1.72124728
92	IgG deficiency (HP:0004315)	1.71840402
93	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.71114798
94	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.69981035
95	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.69701392
96	Hypoplasia of the fovea (HP:0007750)	1.69701392
97	Pachygyria (HP:0001302)	1.69552141
98	Hypoplasia of the radius (HP:0002984)	1.69144687
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69028772
100	Increased muscle lipid content (HP:0009058)	1.68667176

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.31894541
2	NUAK1	3.28933572
3	FRK	3.09568891
4	WNK4	2.47196727
5	GRK1	2.33501813
6	BCKDK	2.25739157
7	ADRBK2	2.14240789
8	PRKD3	2.13984489
9	NME1	2.12005730
10	PHKG1	2.08805392
11	PHKG2	2.08805392
12	CDK19	1.92334894
13	TLK1	1.92043607
14	ZAK	1.83012704
15	PLK4	1.81605450
16	PIK3CA	1.79224297
17	PINK1	1.76708251
18	DYRK2	1.76147945
19	NEK1	1.58388419
20	CAMKK2	1.55634647
21	STK16	1.53576776
22	WNK3	1.51624331
23	BMPR1B	1.47787772
24	MAPK13	1.28167868
25	WNK1	1.27601361
26	VRK1	1.26367461
27	INSRR	1.26157553
28	PIM2	1.25822075
29	DAPK2	1.25801581
30	EPHB2	1.22382406
31	TXK	1.21608737
32	TIE1	1.20984650
33	TSSK6	1.15355800
34	TNIK	1.11675645
35	NME2	1.04421266
36	CDK8	1.02390768
37	CASK	1.01909391
38	OXSR1	1.01207982
39	BMPR2	1.00586090
40	EIF2AK1	0.98425732
41	PLK2	0.98401172
42	MKNK2	0.96996417
43	VRK2	0.96874949
44	PRKCG	0.95100053
45	PASK	0.94916026
46	MAP3K12	0.94679724
47	TAOK3	0.94615591
48	OBSCN	0.88006082
49	PLK3	0.87400546
50	TEC	0.83644229
51	TGFBR1	0.82925483
52	MST4	0.82857464
53	FGFR2	0.82383962
54	ADRBK1	0.82115841
55	CSNK1G2	0.80054022
56	TRPM7	0.78455307
57	TRIM28	0.78319936
58	LRRK2	0.77540425
59	IKBKE	0.76799746
60	GRK7	0.73452866
61	PAK3	0.72393707
62	EIF2AK3	0.71590971
63	CHEK2	0.70146240
64	STK39	0.69535724
65	KIT	0.69434188
66	PDK2	0.69218826
67	PRKCE	0.68631202
68	IKBKB	0.67905790
69	PRKCQ	0.65315122
70	CSNK1G1	0.63944346
71	EIF2AK2	0.63547533
72	ERBB3	0.63492580
73	DAPK3	0.62740190
74	CSNK1G3	0.61832742
75	MKNK1	0.56361930
76	DAPK1	0.52979674
77	ITK	0.51600789
78	PRKCI	0.51453561
79	IRAK1	0.51235751
80	CAMK1	0.50456248
81	BUB1	0.50322441
82	PRKACA	0.49411308
83	SRPK1	0.47856413
84	PIM1	0.47028886
85	CSNK2A2	0.46016823
86	PLK1	0.45673036
87	CAMK1D	0.44395472
88	AURKB	0.42461960
89	PRKCH	0.41648625
90	RPS6KB2	0.40588173
91	CSNK1A1L	0.40520981
92	CDK9	0.39654868
93	CDC7	0.39121810
94	RPS6KA5	0.37760272
95	CSNK2A1	0.36412506
96	STK3	0.36323865
97	ATR	0.35032990
98	PRKCA	0.34018837
99	CAMK2D	0.33668544
100	DMPK	0.33578545

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.70081458
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.32829508
3	Asthma_Homo sapiens_hsa05310	3.06400214
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.00457646
5	Protein export_Homo sapiens_hsa03060	2.80815879
6	Proteasome_Homo sapiens_hsa03050	2.63857227
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.63592344
8	Parkinsons disease_Homo sapiens_hsa05012	2.62998110
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35160775
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.33573145
11	RNA polymerase_Homo sapiens_hsa03020	2.10643521
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.94852993
13	Homologous recombination_Homo sapiens_hsa03440	1.92556440
14	Alzheimers disease_Homo sapiens_hsa05010	1.90024652
15	RNA degradation_Homo sapiens_hsa03018	1.88208322
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.85854184
17	Huntingtons disease_Homo sapiens_hsa05016	1.82253613
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.80684213
19	Allograft rejection_Homo sapiens_hsa05330	1.79374860
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.75199888
21	Propanoate metabolism_Homo sapiens_hsa00640	1.69095353
22	Basal transcription factors_Homo sapiens_hsa03022	1.68441902
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.61627678
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.56006398
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40966724
26	Butanoate metabolism_Homo sapiens_hsa00650	1.39406654
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.39405631
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37341825
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.35888216
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.30379478
31	Phototransduction_Homo sapiens_hsa04744	1.29657440
32	Regulation of autophagy_Homo sapiens_hsa04140	1.27247233
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26394863
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.15441197
35	Sulfur relay system_Homo sapiens_hsa04122	1.09575135
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07396848
37	Purine metabolism_Homo sapiens_hsa00230	1.01939789
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00405174
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99663229
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.99202478
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.98998044
42	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.95505458
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.94040224
44	Nicotine addiction_Homo sapiens_hsa05033	0.92786253
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.90597871
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90291406
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89908254
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.89371555
49	Sulfur metabolism_Homo sapiens_hsa00920	0.88038248
50	RNA transport_Homo sapiens_hsa03013	0.87852074
51	One carbon pool by folate_Homo sapiens_hsa00670	0.84152846
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83363908
53	Spliceosome_Homo sapiens_hsa03040	0.81372772
54	Peroxisome_Homo sapiens_hsa04146	0.78155776
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77592917
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77212009
57	Mismatch repair_Homo sapiens_hsa03430	0.76128654
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74668709
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74130674
60	Folate biosynthesis_Homo sapiens_hsa00790	0.72456949
61	Olfactory transduction_Homo sapiens_hsa04740	0.68689755
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.68539777
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66855636
64	Retinol metabolism_Homo sapiens_hsa00830	0.65965564
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.64303585
66	Metabolic pathways_Homo sapiens_hsa01100	0.63008923
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61390553
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58622855
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58173708
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57347822
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.55305683
72	Base excision repair_Homo sapiens_hsa03410	0.55298779
73	Mineral absorption_Homo sapiens_hsa04978	0.54818457
74	Taste transduction_Homo sapiens_hsa04742	0.54723973
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.53868725
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53214794
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.52442310
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52180368
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51463943
80	Caffeine metabolism_Homo sapiens_hsa00232	0.51020887
81	DNA replication_Homo sapiens_hsa03030	0.48198617
82	Morphine addiction_Homo sapiens_hsa05032	0.47656345
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47412056
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46737540
85	Insulin secretion_Homo sapiens_hsa04911	0.45406780
86	Fatty acid degradation_Homo sapiens_hsa00071	0.44886329
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43487838
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.40886007
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38271553
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37337536
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36995087
92	Antigen processing and presentation_Homo sapiens_hsa04612	0.35476542
93	Serotonergic synapse_Homo sapiens_hsa04726	0.31725169
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30487269
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30460719
96	Glutathione metabolism_Homo sapiens_hsa00480	0.26709866
97	Fatty acid elongation_Homo sapiens_hsa00062	0.26508552
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.26340687
99	Circadian rhythm_Homo sapiens_hsa04710	0.24730760
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.22969793

RPL12P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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