ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	inner mitochondrial membrane organization (GO:0007007)	4.73801148
2	chaperone-mediated protein transport (GO:0072321)	4.64481940
3	dentate gyrus development (GO:0021542)	4.48460291
4	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.04570718
5	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.04570718
6	mitochondrial respiratory chain complex assembly (GO:0033108)	3.97929888
7	keratinocyte development (GO:0003334)	3.90198267
8	protein complex biogenesis (GO:0070271)	3.85130037
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.80802375
10	NADH dehydrogenase complex assembly (GO:0010257)	3.80802375
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.80802375
12	cell proliferation in forebrain (GO:0021846)	3.79045985
13	kinetochore assembly (GO:0051382)	3.68950216
14	kidney morphogenesis (GO:0060993)	3.68565719
15	lactate metabolic process (GO:0006089)	3.65475735
16	ribosomal small subunit assembly (GO:0000028)	3.64431852
17	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.63780017
18	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.63780017
19	neurotransmitter-gated ion channel clustering (GO:0072578)	3.59749384
20	replication fork processing (GO:0031297)	3.59117092
21	regulation of timing of cell differentiation (GO:0048505)	3.57319976
22	aggressive behavior (GO:0002118)	3.55907778
23	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.51932256
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.43381824
25	behavioral response to nicotine (GO:0035095)	3.43055181
26	kinetochore organization (GO:0051383)	3.38635122
27	viral transcription (GO:0019083)	3.37821938
28	negative regulation of astrocyte differentiation (GO:0048712)	3.35526547
29	DNA strand renaturation (GO:0000733)	3.31115007
30	ncRNA 3-end processing (GO:0043628)	3.29496620
31	translational termination (GO:0006415)	3.29471510
32	regulation of development, heterochronic (GO:0040034)	3.27150899
33	GTP biosynthetic process (GO:0006183)	3.11593668
34	negative regulation of acute inflammatory response (GO:0002674)	3.09952248
35	positive regulation of organelle assembly (GO:1902117)	3.06043591
36	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.05710317
37	ATP synthesis coupled proton transport (GO:0015986)	3.05710317
38	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.04019384
39	ribosomal small subunit biogenesis (GO:0042274)	3.01411689
40	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.01352624
41	regulation of centriole replication (GO:0046599)	3.00767407
42	cotranslational protein targeting to membrane (GO:0006613)	2.99089916
43	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.96207974
44	presynaptic membrane assembly (GO:0097105)	2.95815188
45	translational elongation (GO:0006414)	2.94856441
46	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.93177917
47	protein localization to cilium (GO:0061512)	2.91238570
48	protein targeting to ER (GO:0045047)	2.89747457
49	seminiferous tubule development (GO:0072520)	2.84993214
50	piRNA metabolic process (GO:0034587)	2.81842043
51	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.77321995
52	T-helper cell differentiation (GO:0042093)	2.77321995
53	intracellular protein transmembrane import (GO:0044743)	2.75703190
54	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.74884181
55	protein localization to endoplasmic reticulum (GO:0070972)	2.74179736
56	regulation of telomere maintenance (GO:0032204)	2.72094902
57	UTP biosynthetic process (GO:0006228)	2.71668812
58	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.71521207
59	lung-associated mesenchyme development (GO:0060484)	2.70830215
60	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.70332184
61	transmission of nerve impulse (GO:0019226)	2.70000243
62	T cell differentiation involved in immune response (GO:0002292)	2.69364996
63	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.69364996
64	alpha-beta T cell activation involved in immune response (GO:0002287)	2.69364996
65	mitotic sister chromatid cohesion (GO:0007064)	2.68552949
66	regulation of isotype switching to IgG isotypes (GO:0048302)	2.65915683
67	peptidyl-histidine modification (GO:0018202)	2.63907278
68	spinal cord association neuron differentiation (GO:0021527)	2.62888254
69	negative regulation of T-helper cell differentiation (GO:0045623)	2.62317157
70	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.62317157
71	cerebral cortex radially oriented cell migration (GO:0021799)	2.60620138
72	male meiosis I (GO:0007141)	2.58740489
73	cellular component biogenesis (GO:0044085)	2.58334079
74	inositol phosphate catabolic process (GO:0071545)	2.57669796
75	artery smooth muscle contraction (GO:0014824)	2.57056520
76	regulation of chronic inflammatory response (GO:0002676)	2.56414294
77	glyoxylate metabolic process (GO:0046487)	2.56072556
78	prenylation (GO:0097354)	2.55765408
79	protein prenylation (GO:0018342)	2.55765408
80	meiotic chromosome segregation (GO:0045132)	2.53910679
81	somite rostral/caudal axis specification (GO:0032525)	2.49550840
82	DNA replication-dependent nucleosome assembly (GO:0006335)	2.47741498
83	DNA replication-dependent nucleosome organization (GO:0034723)	2.47741498
84	cardiovascular system development (GO:0072358)	2.46542118
85	translational initiation (GO:0006413)	2.46325641
86	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.45833119
87	postsynaptic membrane organization (GO:0001941)	2.45049712
88	behavioral response to ethanol (GO:0048149)	2.44885067
89	vascular smooth muscle contraction (GO:0014829)	2.44508167
90	cytokine production involved in immune response (GO:0002367)	2.44162289
91	regulation of podosome assembly (GO:0071801)	2.44158591
92	mitochondrial RNA metabolic process (GO:0000959)	2.43654399
93	protein polyglutamylation (GO:0018095)	2.43349607
94	telomere maintenance via telomerase (GO:0007004)	2.42601623
95	regulation of immunoglobulin secretion (GO:0051023)	2.41581536
96	G-protein coupled receptor internalization (GO:0002031)	2.40953747
97	limb bud formation (GO:0060174)	2.39648820
98	central nervous system projection neuron axonogenesis (GO:0021952)	2.39606217
99	UTP metabolic process (GO:0046051)	2.38782082
100	negative regulation of glial cell differentiation (GO:0045686)	2.37316129

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.26117041
2	VDR_22108803_ChIP-Seq_LS180_Human	3.63427584
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.61996236
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.11939494
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.98345314
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.90502409
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.58835557
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55980431
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.51659786
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47546164
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.43300904
12	FUS_26573619_Chip-Seq_HEK293_Human	2.30131229
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.28923564
14	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.19573147
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15477712
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.12620041
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.12333044
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06812891
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92319666
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91829285
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91473465
22	EWS_26573619_Chip-Seq_HEK293_Human	1.89072103
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.88828738
24	P300_19829295_ChIP-Seq_ESCs_Human	1.82692408
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80759700
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79426855
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76794083
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71502647
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.68498270
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61022719
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.54685288
32	E2F7_22180533_ChIP-Seq_HELA_Human	1.53924752
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51956260
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47517873
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46819006
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45478927
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.45114017
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.40145472
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38841629
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38217797
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37149777
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.36953733
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35320394
44	EZH2_22144423_ChIP-Seq_EOC_Human	1.33430598
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28588915
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.27191531
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.24292483
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.23109459
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22806677
50	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21679597
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21118351
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21118351
53	STAT3_23295773_ChIP-Seq_U87_Human	1.20947420
54	SOX9_26525672_Chip-Seq_HEART_Mouse	1.18550583
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.17728261
56	TCF4_23295773_ChIP-Seq_U87_Human	1.17476877
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17053807
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16773356
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.16771299
60	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15740294
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14877567
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.13604617
63	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13386552
64	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12476328
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.12120854
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10348508
67	AR_25329375_ChIP-Seq_VCAP_Human	1.09670265
68	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.09250217
69	TTF2_22483619_ChIP-Seq_HELA_Human	1.07554973
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07156516
71	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.06820428
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06657418
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06194046
74	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.05372392
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03738963
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03091209
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02707606
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02380613
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02106764
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02091572
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.02091572
82	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00988407
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99808008
84	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.99335552
85	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98502661
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97935382
87	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.97597140
88	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.97382286
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97110247
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97049405
91	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.96543378
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96522031
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96425692
94	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.95466435
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95219416
96	VDR_23849224_ChIP-Seq_CD4+_Human	0.95202005
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.94440771
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.94101413
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93748574
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93748574

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	3.90362668
2	MP0006292_abnormal_olfactory_placode	3.61555235
3	MP0002938_white_spotting	2.60749775
4	MP0000569_abnormal_digit_pigmentation	2.57462693
5	MP0008877_abnormal_DNA_methylation	2.50290981
6	MP0008995_early_reproductive_senescence	2.49103205
7	MP0005646_abnormal_pituitary_gland	2.36439268
8	MP0001348_abnormal_lacrimal_gland	2.22377911
9	MP0009379_abnormal_foot_pigmentation	2.16403156
10	MP0002736_abnormal_nociception_after	2.15113678
11	MP0002837_dystrophic_cardiac_calcinosis	2.08754385
12	MP0008875_abnormal_xenobiotic_pharmacok	2.04089036
13	MP0003786_premature_aging	2.01744122
14	MP0003890_abnormal_embryonic-extraembry	1.97717498
15	MP0003787_abnormal_imprinting	1.96167328
16	MP0001529_abnormal_vocalization	1.95475611
17	MP0004145_abnormal_muscle_electrophysio	1.94680065
18	MP0000647_abnormal_sebaceous_gland	1.90203018
19	MP0001968_abnormal_touch/_nociception	1.85526259
20	MP0003880_abnormal_central_pattern	1.83772220
21	MP0002735_abnormal_chemical_nociception	1.82533221
22	MP0008789_abnormal_olfactory_epithelium	1.80654557
23	MP0003567_abnormal_fetal_cardiomyocyte	1.79184614
24	MP0001873_stomach_inflammation	1.74398513
25	MP0008058_abnormal_DNA_repair	1.72548433
26	MP0000049_abnormal_middle_ear	1.70596366
27	MP0005645_abnormal_hypothalamus_physiol	1.66238993
28	MP0000778_abnormal_nervous_system	1.63809126
29	MP0009053_abnormal_anal_canal	1.60972540
30	MP0002102_abnormal_ear_morphology	1.60606142
31	MP0003646_muscle_fatigue	1.59871352
32	MP0000427_abnormal_hair_cycle	1.59036322
33	MP0005075_abnormal_melanosome_morpholog	1.55884321
34	MP0005499_abnormal_olfactory_system	1.55336966
35	MP0005394_taste/olfaction_phenotype	1.55336966
36	MP0004215_abnormal_myocardial_fiber	1.52548221
37	MP0003718_maternal_effect	1.41613587
38	MP0005551_abnormal_eye_electrophysiolog	1.41213558
39	MP0001485_abnormal_pinna_reflex	1.35802642
40	MP0002234_abnormal_pharynx_morphology	1.35334661
41	MP0002557_abnormal_social/conspecific_i	1.33456953
42	MP0000631_abnormal_neuroendocrine_gland	1.32954291
43	MP0008872_abnormal_physiological_respon	1.32367284
44	MP0004885_abnormal_endolymph	1.31818033
45	MP0001293_anophthalmia	1.31313093
46	MP0002638_abnormal_pupillary_reflex	1.28500632
47	MP0002163_abnormal_gland_morphology	1.28092315
48	MP0002138_abnormal_hepatobiliary_system	1.21794792
49	MP0005187_abnormal_penis_morphology	1.19742068
50	MP0004142_abnormal_muscle_tone	1.16887030
51	MP0009745_abnormal_behavioral_response	1.16092552
52	MP0006054_spinal_hemorrhage	1.15727780
53	MP0002272_abnormal_nervous_system	1.13994066
54	MP0002095_abnormal_skin_pigmentation	1.13548435
55	MP0005174_abnormal_tail_pigmentation	1.11421896
56	MP0001486_abnormal_startle_reflex	1.10419039
57	MP0003878_abnormal_ear_physiology	1.09571112
58	MP0005377_hearing/vestibular/ear_phenot	1.09571112
59	MP0005379_endocrine/exocrine_gland_phen	1.07429781
60	MP0002277_abnormal_respiratory_mucosa	1.06128255
61	MP0001986_abnormal_taste_sensitivity	1.03801025
62	MP0002876_abnormal_thyroid_physiology	1.02821009
63	MP0002751_abnormal_autonomic_nervous	1.01921423
64	MP0006276_abnormal_autonomic_nervous	1.01584117
65	MP0009250_abnormal_appendicular_skeleto	1.00972926
66	MP0004084_abnormal_cardiac_muscle	1.00474045
67	MP0003011_delayed_dark_adaptation	1.00373052
68	MP0005195_abnormal_posterior_eye	1.00370029
69	MP0000015_abnormal_ear_pigmentation	0.98870188
70	MP0003755_abnormal_palate_morphology	0.95402301
71	MP0010094_abnormal_chromosome_stability	0.87961063
72	MP0001764_abnormal_homeostasis	0.87017089
73	MP0005084_abnormal_gallbladder_morpholo	0.86490031
74	MP0002822_catalepsy	0.86370113
75	MP0000383_abnormal_hair_follicle	0.86363685
76	MP0002572_abnormal_emotion/affect_behav	0.86237124
77	MP0002184_abnormal_innervation	0.85943684
78	MP0009046_muscle_twitch	0.85477589
79	MP0001984_abnormal_olfaction	0.84769887
80	MP0005253_abnormal_eye_physiology	0.83311173
81	MP0003950_abnormal_plasma_membrane	0.82060777
82	MP0005395_other_phenotype	0.77540439
83	MP0002063_abnormal_learning/memory/cond	0.74621803
84	MP0002752_abnormal_somatic_nervous	0.73917224
85	MP0008775_abnormal_heart_ventricle	0.73483136
86	MP0002160_abnormal_reproductive_system	0.72977440
87	MP0003937_abnormal_limbs/digits/tail_de	0.72881545
88	MP0000026_abnormal_inner_ear	0.72766512
89	MP0002653_abnormal_ependyma_morphology	0.71559148
90	MP0003936_abnormal_reproductive_system	0.71287883
91	MP0001324_abnormal_eye_pigmentation	0.71196370
92	MP0000428_abnormal_craniofacial_morphol	0.70944293
93	MP0003186_abnormal_redox_activity	0.70938383
94	MP0003942_abnormal_urinary_system	0.70545614
95	MP0004036_abnormal_muscle_relaxation	0.70423186
96	MP0003935_abnormal_craniofacial_develop	0.70413215
97	MP0002210_abnormal_sex_determination	0.69667587
98	MP0008932_abnormal_embryonic_tissue	0.69141758
99	MP0002233_abnormal_nose_morphology	0.68911757
100	MP0001905_abnormal_dopamine_level	0.68583437

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.94564334
2	Progressive macrocephaly (HP:0004481)	3.53552267
3	Pancreatic fibrosis (HP:0100732)	3.47661640
4	Type II lissencephaly (HP:0007260)	3.44922394
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42675081
6	Volvulus (HP:0002580)	3.18807354
7	Synostosis involving the elbow (HP:0003938)	3.14589986
8	Humeroradial synostosis (HP:0003041)	3.14589986
9	Colon cancer (HP:0003003)	3.09629237
10	Acute encephalopathy (HP:0006846)	3.06290571
11	True hermaphroditism (HP:0010459)	3.03026713
12	Pendular nystagmus (HP:0012043)	3.01404458
13	Mitochondrial inheritance (HP:0001427)	2.99248480
14	Increased hepatocellular lipid droplets (HP:0006565)	2.96060346
15	Pancreatic cysts (HP:0001737)	2.87473992
16	Hyperventilation (HP:0002883)	2.82599507
17	Abnormality of midbrain morphology (HP:0002418)	2.80033974
18	Molar tooth sign on MRI (HP:0002419)	2.80033974
19	Lissencephaly (HP:0001339)	2.76446304
20	Nephronophthisis (HP:0000090)	2.76167617
21	Focal motor seizures (HP:0011153)	2.74156891
22	Rib fusion (HP:0000902)	2.66971331
23	Lipid accumulation in hepatocytes (HP:0006561)	2.66590539
24	Increased CSF lactate (HP:0002490)	2.61166422
25	Anencephaly (HP:0002323)	2.59377200
26	Action tremor (HP:0002345)	2.50710458
27	Abnormality of the 4th metacarpal (HP:0010012)	2.49651284
28	Cerebellar dysplasia (HP:0007033)	2.48531426
29	Broad-based gait (HP:0002136)	2.47726470
30	Abnormality of the renal cortex (HP:0011035)	2.43227089
31	Sclerocornea (HP:0000647)	2.30382893
32	Abnormality of the renal medulla (HP:0100957)	2.28641595
33	Decreased central vision (HP:0007663)	2.27395041
34	Chromsome breakage (HP:0040012)	2.23428983
35	Large for gestational age (HP:0001520)	2.21699104
36	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.21293280
37	Cerebral edema (HP:0002181)	2.18935399
38	Abnormality of the pons (HP:0007361)	2.13139691
39	Intestinal atresia (HP:0011100)	2.08854752
40	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.08452906
41	Retinal dysplasia (HP:0007973)	2.08139897
42	Ependymoma (HP:0002888)	2.05338864
43	Chronic hepatic failure (HP:0100626)	2.05126139
44	Hypothermia (HP:0002045)	2.04916005
45	Increased corneal curvature (HP:0100692)	2.00633364
46	Keratoconus (HP:0000563)	2.00633364
47	Small hand (HP:0200055)	2.00066136
48	Megalencephaly (HP:0001355)	1.99832375
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99621867
50	Renal cortical cysts (HP:0000803)	1.98642650
51	Hepatocellular necrosis (HP:0001404)	1.98099117
52	Focal seizures (HP:0007359)	1.97008512
53	Increased intramyocellular lipid droplets (HP:0012240)	1.92357062
54	Renal Fanconi syndrome (HP:0001994)	1.88619799
55	Maternal diabetes (HP:0009800)	1.88272174
56	Cystic liver disease (HP:0006706)	1.87610051
57	11 pairs of ribs (HP:0000878)	1.87029637
58	Abnormality of the carotid arteries (HP:0005344)	1.84834668
59	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.84241893
60	Hepatic necrosis (HP:0002605)	1.84189479
61	Congenital hepatic fibrosis (HP:0002612)	1.82010175
62	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.81715248
63	Male pseudohermaphroditism (HP:0000037)	1.79316719
64	Tubulointerstitial nephritis (HP:0001970)	1.78617528
65	Narrow forehead (HP:0000341)	1.78446473
66	Pachygyria (HP:0001302)	1.77503411
67	Hyperthyroidism (HP:0000836)	1.74734917
68	Absent thumb (HP:0009777)	1.74663730
69	Abnormality of DNA repair (HP:0003254)	1.74192606
70	Sloping forehead (HP:0000340)	1.74047286
71	Abnormality of the labia minora (HP:0012880)	1.73043328
72	Medial flaring of the eyebrow (HP:0010747)	1.72319749
73	Septo-optic dysplasia (HP:0100842)	1.71732828
74	Abnormality of the ileum (HP:0001549)	1.70033595
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69586188
76	Optic disc pallor (HP:0000543)	1.68735330
77	Hypoplasia of the pons (HP:0012110)	1.68403967
78	Neoplasm of the adrenal cortex (HP:0100641)	1.67749407
79	Meckel diverticulum (HP:0002245)	1.66818770
80	Lactic acidosis (HP:0003128)	1.66528440
81	Abnormality of the metopic suture (HP:0005556)	1.65133799
82	Abnormality of urine glucose concentration (HP:0011016)	1.63752987
83	Glycosuria (HP:0003076)	1.63752987
84	Oligodactyly (hands) (HP:0001180)	1.62413911
85	Multicystic kidney dysplasia (HP:0000003)	1.61833005
86	Short 1st metacarpal (HP:0010034)	1.61465077
87	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.61465077
88	Hypoplastic pelvis (HP:0008839)	1.61303288
89	Aganglionic megacolon (HP:0002251)	1.61121647
90	Dyskinesia (HP:0100660)	1.61071293
91	Ectopic kidney (HP:0000086)	1.60598556
92	Short tibia (HP:0005736)	1.60507475
93	Congenital stationary night blindness (HP:0007642)	1.59439505
94	Tubular atrophy (HP:0000092)	1.59164752
95	Abnormality of the preputium (HP:0100587)	1.58336330
96	Postaxial foot polydactyly (HP:0001830)	1.57540446
97	Renal dysplasia (HP:0000110)	1.57477691
98	Abnormality of the astrocytes (HP:0100707)	1.57088266
99	Astrocytoma (HP:0009592)	1.57088266
100	Gout (HP:0001997)	1.57052254

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	3.75390593
2	FRK	3.32944840
3	CDK19	3.14990203
4	BRD4	3.02925345
5	NUAK1	2.64634080
6	CASK	2.48953323
7	TNIK	2.44432407
8	WNK3	2.33662053
9	NTRK3	2.27052156
10	VRK2	2.24054633
11	NEK9	2.17485231
12	MAP4K2	2.12492310
13	TIE1	1.85308307
14	OBSCN	1.83031842
15	GRK1	1.77803107
16	ADRBK2	1.68137235
17	MARK1	1.63235021
18	MKNK2	1.62527343
19	EPHA4	1.62444564
20	EIF2AK3	1.56899983
21	MAP3K2	1.54529363
22	BMPR1B	1.52858386
23	NME1	1.51478695
24	PLK4	1.48327084
25	TAF1	1.45758132
26	MAP3K12	1.37444010
27	INSRR	1.32446541
28	ZAK	1.32225171
29	PHKG1	1.18760243
30	PHKG2	1.18760243
31	DYRK2	1.15337630
32	WNK4	1.10697883
33	PIK3CA	1.07345937
34	TLK1	1.05724799
35	MKNK1	1.05218156
36	VRK1	1.01219255
37	STK24	1.00579969
38	PRKCG	0.97729589
39	STK39	0.97032502
40	STK4	0.96923629
41	CAMK1D	0.91131217
42	DMPK	0.87025233
43	ILK	0.86020769
44	CAMK1G	0.81567049
45	MAPK13	0.81029543
46	NTRK2	0.79236188
47	PLK3	0.77856302
48	PTK2B	0.75780604
49	OXSR1	0.75728400
50	PIK3CG	0.75346402
51	MAP3K4	0.73521807
52	PLK2	0.73199738
53	LRRK2	0.72675843
54	SRPK1	0.71389228
55	STK3	0.70491684
56	RPS6KB1	0.70355895
57	MYLK	0.67269766
58	ROCK1	0.66006775
59	ACVR1B	0.65658844
60	SMG1	0.65655494
61	CDK8	0.65510849
62	CAMK1	0.64373031
63	BCKDK	0.64243858
64	EIF2AK2	0.64009774
65	FGFR2	0.63947571
66	TGFBR1	0.62258502
67	STK38L	0.61253484
68	PRKCE	0.59304981
69	CCNB1	0.58294001
70	MST4	0.56763844
71	MAP3K9	0.56615796
72	PLK1	0.55651533
73	WEE1	0.54567861
74	STK11	0.54091172
75	MELK	0.53100694
76	CAMK2A	0.53076914
77	PNCK	0.53055853
78	PRKAA2	0.51849283
79	WNK1	0.50729786
80	SIK2	0.50540851
81	NLK	0.50365918
82	KSR1	0.50045034
83	PRKAA1	0.49523563
84	FLT3	0.49418281
85	MAP2K4	0.48472234
86	ADRBK1	0.47387172
87	CSNK1G2	0.43580333
88	PRKDC	0.42203782
89	ATM	0.41124085
90	CHEK1	0.39837527
91	PRKCQ	0.39774229
92	CAMK2D	0.39597039
93	PAK3	0.39549285
94	CSNK1D	0.39322557
95	PRKD3	0.39081764
96	BUB1	0.38989923
97	LIMK1	0.37536118
98	PASK	0.36190843
99	PRKCZ	0.35970017
100	CAMKK2	0.34724835

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.62087940
2	RNA polymerase_Homo sapiens_hsa03020	2.66026309
3	Nucleotide excision repair_Homo sapiens_hsa03420	2.40562644
4	Mismatch repair_Homo sapiens_hsa03430	2.36725152
5	Protein export_Homo sapiens_hsa03060	2.31181345
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.30968167
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.29663658
8	Basal transcription factors_Homo sapiens_hsa03022	2.23728444
9	Nicotine addiction_Homo sapiens_hsa05033	2.18136490
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15191133
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.09415886
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.97508079
13	Homologous recombination_Homo sapiens_hsa03440	1.89617909
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.87627363
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86007822
16	DNA replication_Homo sapiens_hsa03030	1.84701689
17	Parkinsons disease_Homo sapiens_hsa05012	1.83782432
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.81833755
19	Phototransduction_Homo sapiens_hsa04744	1.74697858
20	Asthma_Homo sapiens_hsa05310	1.70818959
21	One carbon pool by folate_Homo sapiens_hsa00670	1.70718122
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.67306917
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57516638
24	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.57213767
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56811921
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.54498712
27	Huntingtons disease_Homo sapiens_hsa05016	1.52281894
28	RNA degradation_Homo sapiens_hsa03018	1.40430675
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.40074950
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38686359
31	Butanoate metabolism_Homo sapiens_hsa00650	1.36965622
32	Base excision repair_Homo sapiens_hsa03410	1.34898212
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33117335
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32175695
35	Olfactory transduction_Homo sapiens_hsa04740	1.31158402
36	Peroxisome_Homo sapiens_hsa04146	1.30720100
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28520981
38	RNA transport_Homo sapiens_hsa03013	1.22630993
39	Purine metabolism_Homo sapiens_hsa00230	1.14154985
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.09532967
41	Alzheimers disease_Homo sapiens_hsa05010	1.09075866
42	Fat digestion and absorption_Homo sapiens_hsa04975	1.06626645
43	Propanoate metabolism_Homo sapiens_hsa00640	1.04981467
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.04859399
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02970216
46	Morphine addiction_Homo sapiens_hsa05032	1.02699598
47	Folate biosynthesis_Homo sapiens_hsa00790	0.98928669
48	Fatty acid degradation_Homo sapiens_hsa00071	0.97810328
49	Proteasome_Homo sapiens_hsa03050	0.97250171
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90981021
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90185755
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86749702
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86650886
54	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.86334325
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85834822
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.84716400
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84152099
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83611868
59	Circadian entrainment_Homo sapiens_hsa04713	0.82769820
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81344722
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80189845
62	Spliceosome_Homo sapiens_hsa03040	0.78788786
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.78196221
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.77081250
65	Taste transduction_Homo sapiens_hsa04742	0.74681051
66	Allograft rejection_Homo sapiens_hsa05330	0.74513829
67	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73445587
68	Insulin secretion_Homo sapiens_hsa04911	0.73427247
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71856410
70	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.70529853
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.69355135
72	Caffeine metabolism_Homo sapiens_hsa00232	0.65944105
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65696860
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65566706
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64298943
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64251033
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.63117854
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.61562009
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.59915100
80	Retinol metabolism_Homo sapiens_hsa00830	0.58849032
81	GABAergic synapse_Homo sapiens_hsa04727	0.56037943
82	Renin secretion_Homo sapiens_hsa04924	0.51523269
83	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51436789
84	Metabolic pathways_Homo sapiens_hsa01100	0.49233077
85	Cell cycle_Homo sapiens_hsa04110	0.48942463
86	Long-term depression_Homo sapiens_hsa04730	0.48357609
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.47748330
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.45347338
89	Melanoma_Homo sapiens_hsa05218	0.43331297
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.42181231
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41915266
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.41539690
93	Lysine degradation_Homo sapiens_hsa00310	0.38804046
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37085044
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.35507641
96	Serotonergic synapse_Homo sapiens_hsa04726	0.35251814
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31202785
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27468670
99	Cholinergic synapse_Homo sapiens_hsa04725	0.26782674
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.26084128

RPL12P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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