ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.89048136
2	viral transcription (GO:0019083)	8.59900442
3	translational termination (GO:0006415)	8.25924661
4	maturation of SSU-rRNA (GO:0030490)	8.02062574
5	ribosomal small subunit assembly (GO:0000028)	7.40886768
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.06967324
7	cotranslational protein targeting to membrane (GO:0006613)	6.97969033
8	translational elongation (GO:0006414)	6.97952752
9	protein targeting to ER (GO:0045047)	6.89400592
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.61391280
11	protein localization to endoplasmic reticulum (GO:0070972)	6.43809088
12	chaperone-mediated protein transport (GO:0072321)	6.32709213
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.29069543
14	cellular protein complex disassembly (GO:0043624)	6.25719320
15	viral life cycle (GO:0019058)	6.11189405
16	translational initiation (GO:0006413)	5.51178297
17	ATP synthesis coupled proton transport (GO:0015986)	5.48648632
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.48648632
19	protein complex disassembly (GO:0043241)	5.37570329
20	ribosomal large subunit biogenesis (GO:0042273)	5.12978758
21	macromolecular complex disassembly (GO:0032984)	5.05346525
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.83416320
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.77565835
24	protein targeting to membrane (GO:0006612)	4.59420855
25	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.51508008
26	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.50704835
27	translation (GO:0006412)	4.49992223
28	ribonucleoprotein complex biogenesis (GO:0022613)	4.35155956
29	GTP biosynthetic process (GO:0006183)	4.25413859
30	mRNA catabolic process (GO:0006402)	4.22979606
31	protein neddylation (GO:0045116)	4.05710706
32	respiratory electron transport chain (GO:0022904)	3.97745009
33	nonmotile primary cilium assembly (GO:0035058)	3.97567802
34	cellular component biogenesis (GO:0044085)	3.94918109
35	electron transport chain (GO:0022900)	3.92556979
36	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.90193707
37	RNA catabolic process (GO:0006401)	3.84044827
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.76270283
39	NADH dehydrogenase complex assembly (GO:0010257)	3.76270283
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.76270283
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.75106536
42	behavioral response to nicotine (GO:0035095)	3.72959280
43	respiratory chain complex IV assembly (GO:0008535)	3.72591872
44	UTP biosynthetic process (GO:0006228)	3.70804433
45	ncRNA 3-end processing (GO:0043628)	3.68195586
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.63276798
47	ATP biosynthetic process (GO:0006754)	3.59220013
48	protein complex biogenesis (GO:0070271)	3.58642384
49	UTP metabolic process (GO:0046051)	3.52163743
50	rRNA modification (GO:0000154)	3.51604711
51	DNA damage response, detection of DNA damage (GO:0042769)	3.49765333
52	rRNA processing (GO:0006364)	3.43541420
53	rRNA metabolic process (GO:0016072)	3.40785107
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38235083
55	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.37723167
56	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.37264310
57	guanosine-containing compound biosynthetic process (GO:1901070)	3.35776146
58	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.32597144
59	pyrimidine nucleotide catabolic process (GO:0006244)	3.30635162
60	protein targeting (GO:0006605)	3.28508623
61	CTP biosynthetic process (GO:0006241)	3.26273267
62	CTP metabolic process (GO:0046036)	3.26273267
63	protein targeting to mitochondrion (GO:0006626)	3.23418965
64	protein polyglutamylation (GO:0018095)	3.22378539
65	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.22315673
66	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.22135274
67	termination of RNA polymerase III transcription (GO:0006386)	3.22135274
68	rRNA catabolic process (GO:0016075)	3.17831688
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.14952851
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.14209285
71	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.13411838
72	water-soluble vitamin biosynthetic process (GO:0042364)	3.11730176
73	cytochrome complex assembly (GO:0017004)	3.09841158
74	establishment of protein localization to membrane (GO:0090150)	3.06792971
75	establishment of protein localization to organelle (GO:0072594)	3.06158887
76	pseudouridine synthesis (GO:0001522)	2.97215186
77	motile cilium assembly (GO:0044458)	2.95580788
78	nucleoside triphosphate biosynthetic process (GO:0009142)	2.95028699
79	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.92340937
80	peptidyl-histidine modification (GO:0018202)	2.90952903
81	cell proliferation in forebrain (GO:0021846)	2.88704353
82	establishment of protein localization to mitochondrion (GO:0072655)	2.88429605
83	ncRNA catabolic process (GO:0034661)	2.87041961
84	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.82735349
85	protein localization to mitochondrion (GO:0070585)	2.76930086
86	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.75262356
87	rRNA methylation (GO:0031167)	2.71980120
88	positive regulation of T cell apoptotic process (GO:0070234)	2.71009771
89	aldehyde catabolic process (GO:0046185)	2.69638077
90	inositol phosphate dephosphorylation (GO:0046855)	2.67651343
91	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.67651343
92	positive regulation of protein homooligomerization (GO:0032464)	2.65991037
93	substrate-independent telencephalic tangential migration (GO:0021826)	2.65504083
94	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.65504083
95	hydrogen ion transmembrane transport (GO:1902600)	2.64837840
96	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.61134708
97	response to misfolded protein (GO:0051788)	2.59728619
98	myoblast migration (GO:0051451)	2.58944487
99	negative regulation of T cell differentiation in thymus (GO:0033085)	2.58072641
100	cardiovascular system development (GO:0072358)	2.57819853

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.70367053
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.62470812
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.47792597
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.19870358
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.05100709
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.91764796
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89763592
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86426280
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.66433842
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.64414197
11	TTF2_22483619_ChIP-Seq_HELA_Human	2.45012787
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.37822658
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.37450538
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.17428239
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.11571624
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.09816261
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.00443537
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.93367460
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92370959
20	GABP_19822575_ChIP-Seq_HepG2_Human	1.91971528
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.87990537
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.83648411
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.82972855
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.71410081
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.71250652
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.70671520
27	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.69951028
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63566004
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61870271
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57292451
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56636070
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.56317532
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.55623280
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.53961889
35	ZNF274_21170338_ChIP-Seq_K562_Hela	1.50865775
36	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.50726950
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.50520896
38	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.48293458
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.46409460
40	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.44835957
41	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.41145387
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.36418632
43	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35300194
44	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.34970722
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.34346405
46	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.31528902
47	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.30214706
48	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.29511338
49	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.28889317
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28333050
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27573908
52	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26692713
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.26586270
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26341262
55	ERA_21632823_ChIP-Seq_H3396_Human	1.24912648
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24334246
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23047006
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21454740
59	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.20648541
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20232858
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19782963
62	KDM5A_27292631_Chip-Seq_BREAST_Human	1.18833844
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.15647313
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14469746
65	EWS_26573619_Chip-Seq_HEK293_Human	1.13779333
66	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.13088010
67	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.09736912
68	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.08533741
69	VDR_22108803_ChIP-Seq_LS180_Human	1.07179739
70	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.07036597
71	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03823005
72	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.03817847
73	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.03817847
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01908104
75	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01637165
76	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.01090766
77	FUS_26573619_Chip-Seq_HEK293_Human	0.99523326
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99072481
79	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.97264939
80	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95991007
81	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.95732240
82	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.95629268
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95581807
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94569625
85	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93690886
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93203744
87	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.91874486
88	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.91449649
89	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.88211807
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87486634
91	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.86474804
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.86017069
93	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85843276
94	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85279258
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.85034700
96	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.84792152
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84549084
98	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.84547386
99	P53_21459846_ChIP-Seq_SAOS-2_Human	0.84174586
100	NCOR_22424771_ChIP-Seq_293T_Human	0.83824895

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.30991259
2	MP0006292_abnormal_olfactory_placode	4.48361248
3	MP0005646_abnormal_pituitary_gland	3.08995246
4	MP0003123_paternal_imprinting	3.07048893
5	MP0003787_abnormal_imprinting	3.06522552
6	MP0008877_abnormal_DNA_methylation	2.81748348
7	MP0003122_maternal_imprinting	2.57496914
8	MP0008789_abnormal_olfactory_epithelium	2.38798243
9	MP0002163_abnormal_gland_morphology	2.34590656
10	MP0001293_anophthalmia	2.32375151
11	MP0003121_genomic_imprinting	2.19816543
12	MP0000049_abnormal_middle_ear	2.13969891
13	MP0004142_abnormal_muscle_tone	2.12920190
14	MP0005394_taste/olfaction_phenotype	2.05750743
15	MP0005499_abnormal_olfactory_system	2.05750743
16	MP0001348_abnormal_lacrimal_gland	1.94501196
17	MP0005379_endocrine/exocrine_gland_phen	1.70417028
18	MP0001529_abnormal_vocalization	1.66010496
19	MP0002160_abnormal_reproductive_system	1.65886018
20	MP0005377_hearing/vestibular/ear_phenot	1.64064343
21	MP0003878_abnormal_ear_physiology	1.64064343
22	MP0002876_abnormal_thyroid_physiology	1.48620189
23	MP0003315_abnormal_perineum_morphology	1.47014169
24	MP0002837_dystrophic_cardiac_calcinosis	1.44763024
25	MP0001984_abnormal_olfaction	1.44195412
26	MP0001485_abnormal_pinna_reflex	1.40864743
27	MP0006276_abnormal_autonomic_nervous	1.40821284
28	MP0000631_abnormal_neuroendocrine_gland	1.39707445
29	MP0000778_abnormal_nervous_system	1.38034406
30	MP0003693_abnormal_embryo_hatching	1.38030782
31	MP0003011_delayed_dark_adaptation	1.36952441
32	MP0005551_abnormal_eye_electrophysiolog	1.33792058
33	MP0000566_synostosis	1.30184622
34	MP0005389_reproductive_system_phenotype	1.28159477
35	MP0005084_abnormal_gallbladder_morpholo	1.26418972
36	MP0002234_abnormal_pharynx_morphology	1.26186198
37	MP0002653_abnormal_ependyma_morphology	1.25725510
38	MP0009046_muscle_twitch	1.25232106
39	MP0003186_abnormal_redox_activity	1.21716386
40	MP0005195_abnormal_posterior_eye	1.21437534
41	MP0003646_muscle_fatigue	1.20704895
42	MP0004885_abnormal_endolymph	1.19314738
43	MP0002233_abnormal_nose_morphology	1.18818171
44	MP0002938_white_spotting	1.18595899
45	MP0002557_abnormal_social/conspecific_i	1.16156536
46	MP0010030_abnormal_orbit_morphology	1.15273383
47	MP0003937_abnormal_limbs/digits/tail_de	1.14281797
48	MP0000678_abnormal_parathyroid_gland	1.14242458
49	MP0003890_abnormal_embryonic-extraembry	1.13940271
50	MP0009745_abnormal_behavioral_response	1.12474044
51	MP0001905_abnormal_dopamine_level	1.12417225
52	MP0004858_abnormal_nervous_system	1.09963999
53	MP0001440_abnormal_grooming_behavior	1.08988610
54	MP0006036_abnormal_mitochondrial_physio	1.07612949
55	MP0004145_abnormal_muscle_electrophysio	1.05672256
56	MP0003567_abnormal_fetal_cardiomyocyte	1.03218195
57	MP0002210_abnormal_sex_determination	1.02932209
58	MP0003938_abnormal_ear_development	1.02394478
59	MP0002184_abnormal_innervation	0.98932707
60	MP0001324_abnormal_eye_pigmentation	0.98187587
61	MP0002138_abnormal_hepatobiliary_system	0.97922231
62	MP0002272_abnormal_nervous_system	0.95685452
63	MP0008058_abnormal_DNA_repair	0.95369013
64	MP0005360_urolithiasis	0.95219691
65	MP0000955_abnormal_spinal_cord	0.94921436
66	MP0004742_abnormal_vestibular_system	0.93588684
67	MP0005423_abnormal_somatic_nervous	0.93491206
68	MP0002752_abnormal_somatic_nervous	0.92150867
69	MP0002735_abnormal_chemical_nociception	0.91263893
70	MP0001286_abnormal_eye_development	0.91025612
71	MP0006072_abnormal_retinal_apoptosis	0.90940158
72	MP0004133_heterotaxia	0.90757946
73	MP0001968_abnormal_touch/_nociception	0.88154385
74	MP0002095_abnormal_skin_pigmentation	0.87957211
75	MP0008872_abnormal_physiological_respon	0.87897623
76	MP0003698_abnormal_male_reproductive	0.86342299
77	MP0001963_abnormal_hearing_physiology	0.86105492
78	MP0001919_abnormal_reproductive_system	0.85243816
79	MP0001486_abnormal_startle_reflex	0.84006458
80	MP0008875_abnormal_xenobiotic_pharmacok	0.83927631
81	MP0005187_abnormal_penis_morphology	0.83600010
82	MP0001929_abnormal_gametogenesis	0.83123390
83	MP0003942_abnormal_urinary_system	0.82584490
84	MP0001764_abnormal_homeostasis	0.81539348
85	MP0001145_abnormal_male_reproductive	0.81460698
86	MP0000026_abnormal_inner_ear	0.81408746
87	MP0002249_abnormal_larynx_morphology	0.81004356
88	MP0002572_abnormal_emotion/affect_behav	0.80459015
89	MP0005391_vision/eye_phenotype	0.79471795
90	MP0002822_catalepsy	0.79306301
91	MP0009053_abnormal_anal_canal	0.78465520
92	MP0001188_hyperpigmentation	0.78125074
93	MP0000653_abnormal_sex_gland	0.77011370
94	MP0003195_calcinosis	0.77001829
95	MP0001970_abnormal_pain_threshold	0.76318389
96	MP0002064_seizures	0.76005839
97	MP0001986_abnormal_taste_sensitivity	0.75322322
98	MP0000613_abnormal_salivary_gland	0.74950572
99	MP0004811_abnormal_neuron_physiology	0.74845631
100	MP0008007_abnormal_cellular_replicative	0.74172357

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.67102528
2	Acute necrotizing encephalopathy (HP:0006965)	4.21023883
3	Macrocytic anemia (HP:0001972)	3.99497120
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.99282176
5	Abnormality of midbrain morphology (HP:0002418)	3.90746236
6	Molar tooth sign on MRI (HP:0002419)	3.90746236
7	Mitochondrial inheritance (HP:0001427)	3.82022648
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.79220670
9	Acute encephalopathy (HP:0006846)	3.50413719
10	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.46494218
11	Increased CSF lactate (HP:0002490)	3.45604973
12	Hepatocellular necrosis (HP:0001404)	3.43863389
13	Progressive macrocephaly (HP:0004481)	3.39167030
14	Hepatic necrosis (HP:0002605)	3.22211662
15	Medial flaring of the eyebrow (HP:0010747)	3.20926953
16	Pallor (HP:0000980)	3.11570893
17	Pancreatic fibrosis (HP:0100732)	3.04274628
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.02092879
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.02092879
20	Stenosis of the external auditory canal (HP:0000402)	2.90290609
21	Abnormality of DNA repair (HP:0003254)	2.87598197
22	Cerebral edema (HP:0002181)	2.84784477
23	Gait imbalance (HP:0002141)	2.83232623
24	Sclerocornea (HP:0000647)	2.76299774
25	Nephrogenic diabetes insipidus (HP:0009806)	2.72212355
26	Congenital primary aphakia (HP:0007707)	2.71008964
27	Increased hepatocellular lipid droplets (HP:0006565)	2.68930391
28	Abnormal number of erythroid precursors (HP:0012131)	2.57311501
29	Abnormal hemoglobin (HP:0011902)	2.56849414
30	Lipid accumulation in hepatocytes (HP:0006561)	2.54462724
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.50924711
32	Nephronophthisis (HP:0000090)	2.47944569
33	Myokymia (HP:0002411)	2.45183869
34	Hyperglycinemia (HP:0002154)	2.44023920
35	Asplenia (HP:0001746)	2.42248829
36	Renal Fanconi syndrome (HP:0001994)	2.40744060
37	Type II lissencephaly (HP:0007260)	2.40302247
38	Adrenal hypoplasia (HP:0000835)	2.36746132
39	Increased serum lactate (HP:0002151)	2.32014407
40	Type 2 muscle fiber atrophy (HP:0003554)	2.30538350
41	Lactic acidosis (HP:0003128)	2.30424045
42	Increased intramyocellular lipid droplets (HP:0012240)	2.24774961
43	Hypoplastic pelvis (HP:0008839)	2.24228771
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.23746607
45	True hermaphroditism (HP:0010459)	2.19299896
46	Hyperthyroidism (HP:0000836)	2.18180588
47	Abnormality of the labia minora (HP:0012880)	2.15207976
48	Absent thumb (HP:0009777)	2.14750135
49	Depressed nasal ridge (HP:0000457)	2.13750772
50	Colon cancer (HP:0003003)	2.12254583
51	Septo-optic dysplasia (HP:0100842)	2.11484555
52	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.11175895
53	Optic disc pallor (HP:0000543)	2.10691271
54	Muscle fiber atrophy (HP:0100295)	2.10560196
55	Pendular nystagmus (HP:0012043)	2.08929385
56	Hypoplasia of the radius (HP:0002984)	2.07906611
57	Respiratory failure (HP:0002878)	2.07364706
58	Poor suck (HP:0002033)	2.07108304
59	Pancreatic cysts (HP:0001737)	2.05851608
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.04998894
61	Vaginal atresia (HP:0000148)	2.03248968
62	Genital tract atresia (HP:0001827)	2.01412988
63	Anophthalmia (HP:0000528)	2.00948909
64	Anencephaly (HP:0002323)	2.00416669
65	Entropion (HP:0000621)	2.00157273
66	Poor coordination (HP:0002370)	1.96795007
67	Renal cortical cysts (HP:0000803)	1.96597167
68	Congenital stationary night blindness (HP:0007642)	1.95122714
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94816947
70	11 pairs of ribs (HP:0000878)	1.93858625
71	Chronic hepatic failure (HP:0100626)	1.93537911
72	3-Methylglutaconic aciduria (HP:0003535)	1.92782755
73	Microretrognathia (HP:0000308)	1.91561676
74	Multiple enchondromatosis (HP:0005701)	1.90961287
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.89927232
76	Absent/shortened dynein arms (HP:0200106)	1.89927232
77	Increased muscle lipid content (HP:0009058)	1.89707472
78	Papilledema (HP:0001085)	1.89352180
79	Abnormality of the renal medulla (HP:0100957)	1.86265170
80	Postaxial foot polydactyly (HP:0001830)	1.85784304
81	Triphalangeal thumb (HP:0001199)	1.85385070
82	Abnormality of urine glucose concentration (HP:0011016)	1.83761382
83	Glycosuria (HP:0003076)	1.83761382
84	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83085379
85	Abnormality of the renal cortex (HP:0011035)	1.80633658
86	Abnormality of renal resorption (HP:0011038)	1.80590909
87	Leukodystrophy (HP:0002415)	1.76639120
88	Hypoplasia of the pons (HP:0012110)	1.76189252
89	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76116700
90	Abnormality of alanine metabolism (HP:0010916)	1.76116700
91	Hyperalaninemia (HP:0003348)	1.76116700
92	Agitation (HP:0000713)	1.74210203
93	Exercise intolerance (HP:0003546)	1.74201752
94	High anterior hairline (HP:0009890)	1.73991368
95	Bifid tongue (HP:0010297)	1.73490802
96	Lethargy (HP:0001254)	1.73448792
97	Abnormal rod and cone electroretinograms (HP:0008323)	1.70728491
98	Confusion (HP:0001289)	1.69818528
99	Abnormality of the aortic arch (HP:0012303)	1.68954380
100	Preaxial hand polydactyly (HP:0001177)	1.68591288

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.54121949
2	STK39	2.83265201
3	CDK19	2.67539804
4	DYRK2	2.65279504
5	NME2	2.64766461
6	NUAK1	2.55962577
7	TNIK	2.53433496
8	PIK3CA	2.48734362
9	BCKDK	2.34656672
10	MAP4K2	2.18742970
11	GRK1	2.14859609
12	LRRK2	2.10851817
13	ADRBK2	1.77471676
14	CAMK1D	1.72866663
15	FRK	1.70209438
16	TIE1	1.63767336
17	OXSR1	1.63414857
18	CAMK1G	1.61514521
19	CDC7	1.60783433
20	CAMKK2	1.54179344
21	ARAF	1.53622879
22	STK16	1.51121869
23	PRKCG	1.45799743
24	TAF1	1.35615059
25	MAP3K11	1.33145400
26	PRKCI	1.32417356
27	NTRK2	1.30692125
28	PRKD3	1.27224675
29	CAMK1	1.23508339
30	VRK2	1.21412396
31	PINK1	1.20832634
32	EPHB2	1.19952982
33	BRAF	1.16371095
34	WNK3	1.15699459
35	TXK	1.08591094
36	PAK3	1.07382710
37	MAP3K9	1.07161210
38	CSNK2A2	1.06086056
39	PDK2	0.97568809
40	AURKA	0.97459862
41	BMPR1B	0.95572577
42	PLK1	0.95175337
43	CASK	0.94878896
44	PLK2	0.94633267
45	CSNK1G2	0.93360694
46	MAP2K7	0.90816528
47	PIM2	0.90181298
48	TGFBR1	0.87881584
49	PASK	0.86194721
50	DMPK	0.81976903
51	MINK1	0.80008955
52	MAP3K4	0.79491248
53	PRKCH	0.76109370
54	PLK4	0.74933323
55	INSRR	0.68308120
56	PNCK	0.68061892
57	STK11	0.67688166
58	ADRBK1	0.66428618
59	ABL2	0.65947675
60	CSNK1E	0.65241786
61	CSNK1G3	0.64527444
62	CDK7	0.63484062
63	CSNK2A1	0.61394357
64	CDK11A	0.61142659
65	NEK1	0.61061850
66	NME1	0.61047205
67	VRK1	0.58287220
68	CSNK1G1	0.58068457
69	AURKB	0.57546059
70	ATR	0.56471514
71	PRKACA	0.55624216
72	LIMK1	0.55365870
73	WNK1	0.54406658
74	MAP2K4	0.53970893
75	PRKCQ	0.53479576
76	PLK3	0.53384659
77	PRKCD	0.51197308
78	FLT3	0.50529870
79	DYRK1A	0.48925610
80	CDK14	0.48356789
81	PHKG2	0.47780221
82	PHKG1	0.47780221
83	RPS6KA6	0.47749887
84	CHEK1	0.47467253
85	PRKCZ	0.47045663
86	TLK1	0.45281590
87	CSNK1A1	0.44681964
88	CHEK2	0.43417676
89	BRSK2	0.43167216
90	CAMK4	0.43115702
91	DYRK1B	0.41800697
92	CDK3	0.41787066
93	EIF2AK2	0.41591237
94	GRK5	0.41066079
95	DAPK3	0.41004345
96	CDK15	0.40908721
97	MAP3K12	0.40063034
98	CAMK2A	0.38697436
99	CDK2	0.38270593
100	ICK	0.37639783

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.01271162
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.07136946
3	Parkinsons disease_Homo sapiens_hsa05012	3.41412184
4	Huntingtons disease_Homo sapiens_hsa05016	2.59157291
5	Alzheimers disease_Homo sapiens_hsa05010	2.38684800
6	RNA polymerase_Homo sapiens_hsa03020	2.32824703
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.28744652
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.21643807
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.08214712
10	Protein export_Homo sapiens_hsa03060	2.03431018
11	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.02613991
12	Sulfur relay system_Homo sapiens_hsa04122	2.02154098
13	Nucleotide excision repair_Homo sapiens_hsa03420	1.84348028
14	DNA replication_Homo sapiens_hsa03030	1.81409412
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.70614761
16	RNA degradation_Homo sapiens_hsa03018	1.66819781
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56777096
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56205262
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53306599
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.46777692
21	Base excision repair_Homo sapiens_hsa03410	1.45538143
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.42080135
23	Butanoate metabolism_Homo sapiens_hsa00650	1.41769184
24	One carbon pool by folate_Homo sapiens_hsa00670	1.41354354
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.38491457
26	Folate biosynthesis_Homo sapiens_hsa00790	1.34974067
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32915692
28	Mismatch repair_Homo sapiens_hsa03430	1.26984601
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22668399
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.22217270
31	Sulfur metabolism_Homo sapiens_hsa00920	1.21731716
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21372545
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19906513
34	Basal transcription factors_Homo sapiens_hsa03022	1.17174523
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.16851656
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14950504
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.12705227
38	Purine metabolism_Homo sapiens_hsa00230	1.09763533
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06553195
40	Fatty acid degradation_Homo sapiens_hsa00071	1.03095245
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.02749242
42	Homologous recombination_Homo sapiens_hsa03440	1.02006587
43	Peroxisome_Homo sapiens_hsa04146	1.01059254
44	Phototransduction_Homo sapiens_hsa04744	0.98550623
45	RNA transport_Homo sapiens_hsa03013	0.96049731
46	Proteasome_Homo sapiens_hsa03050	0.93685656
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91367249
48	Metabolic pathways_Homo sapiens_hsa01100	0.86379893
49	Propanoate metabolism_Homo sapiens_hsa00640	0.86356355
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85902389
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81960611
52	Spliceosome_Homo sapiens_hsa03040	0.80080537
53	Fatty acid elongation_Homo sapiens_hsa00062	0.78697267
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78166989
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76852677
56	Caffeine metabolism_Homo sapiens_hsa00232	0.73388570
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.72321382
58	Nicotine addiction_Homo sapiens_hsa05033	0.72072780
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71847115
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.71109026
61	Retinol metabolism_Homo sapiens_hsa00830	0.70287772
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67784623
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66999141
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66660010
65	Olfactory transduction_Homo sapiens_hsa04740	0.66270692
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65871211
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65770217
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65623028
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65616553
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.62611470
71	Insulin secretion_Homo sapiens_hsa04911	0.60839925
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.60144457
73	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.54498032
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54339539
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51458034
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50833592
77	Asthma_Homo sapiens_hsa05310	0.48244626
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.46703265
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45204045
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41679845
81	Glutathione metabolism_Homo sapiens_hsa00480	0.40537974
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.37731114
83	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.33750940
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33103413
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33000362
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31446423
87	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.26533437
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26207917
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.25296989
90	Morphine addiction_Homo sapiens_hsa05032	0.24906627
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24612593
92	Carbon metabolism_Homo sapiens_hsa01200	0.21091970
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.21063922
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.19972819
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.19707554
96	Regulation of autophagy_Homo sapiens_hsa04140	0.19620703
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18262749
98	Lysine degradation_Homo sapiens_hsa00310	0.18155272
99	Taste transduction_Homo sapiens_hsa04742	0.16863819
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.16560232

RPL12P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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