ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.03191990
2	DNA deamination (GO:0045006)	5.86344316
3	base-excision repair, AP site formation (GO:0006285)	5.58127465
4	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.31687944
5	viral transcription (GO:0019083)	5.11780404
6	translational termination (GO:0006415)	4.97524412
7	cytidine deamination (GO:0009972)	4.97515522
8	cytidine metabolic process (GO:0046087)	4.97515522
9	cytidine catabolic process (GO:0006216)	4.97515522
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.93218665
11	centriole replication (GO:0007099)	4.69191847
12	ribosomal large subunit biogenesis (GO:0042273)	4.55839065
13	pyrimidine nucleotide catabolic process (GO:0006244)	4.55424137
14	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.54635575
15	chaperone-mediated protein transport (GO:0072321)	4.51821469
16	cotranslational protein targeting to membrane (GO:0006613)	4.47712870
17	protein targeting to ER (GO:0045047)	4.46361654
18	translational elongation (GO:0006414)	4.34762982
19	rRNA catabolic process (GO:0016075)	4.34745387
20	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.32295338
21	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.26567801
22	response to pheromone (GO:0019236)	4.23666149
23	protein localization to endoplasmic reticulum (GO:0070972)	4.22683355
24	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.20302804
25	epithelial cilium movement (GO:0003351)	4.14574790
26	nucleoside diphosphate catabolic process (GO:0009134)	4.02256405
27	axonemal dynein complex assembly (GO:0070286)	3.98837626
28	ribosomal small subunit biogenesis (GO:0042274)	3.94514444
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.93082886
30	cellular protein complex disassembly (GO:0043624)	3.83319646
31	sperm motility (GO:0030317)	3.82896041
32	tyrosine phosphorylation of STAT protein (GO:0007260)	3.82105664
33	ATP synthesis coupled proton transport (GO:0015986)	3.72915193
34	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.72915193
35	translational initiation (GO:0006413)	3.70464773
36	positive regulation of monocyte chemotaxis (GO:0090026)	3.64744427
37	cellular response to interferon-beta (GO:0035458)	3.62414917
38	viral life cycle (GO:0019058)	3.59181127
39	positive regulation of defense response to virus by host (GO:0002230)	3.55394889
40	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.54803460
41	centriole assembly (GO:0098534)	3.53662558
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.51977942
43	protein polyglutamylation (GO:0018095)	3.48634070
44	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.46957972
45	protein complex biogenesis (GO:0070271)	3.45670440
46	maturation of SSU-rRNA (GO:0030490)	3.44175778
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.44102113
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.44102113
49	NADH dehydrogenase complex assembly (GO:0010257)	3.44102113
50	regulation of cilium movement (GO:0003352)	3.34627447
51	cellular response to interleukin-15 (GO:0071350)	3.32424935
52	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.32190299
53	cilium movement (GO:0003341)	3.31138609
54	rRNA modification (GO:0000154)	3.29745149
55	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.24878201
56	deoxyribonucleotide catabolic process (GO:0009264)	3.23641697
57	protein complex disassembly (GO:0043241)	3.23170521
58	fusion of sperm to egg plasma membrane (GO:0007342)	3.21308621
59	translation (GO:0006412)	3.19910169
60	deoxyribose phosphate catabolic process (GO:0046386)	3.15483919
61	positive regulation of T cell apoptotic process (GO:0070234)	3.14588232
62	regulation of chronic inflammatory response (GO:0002676)	3.13747732
63	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11712958
64	negative regulation by host of viral transcription (GO:0043922)	3.08085799
65	ribonucleoprotein complex biogenesis (GO:0022613)	3.08007516
66	positive regulation of mitochondrial fission (GO:0090141)	3.05792905
67	macromolecular complex disassembly (GO:0032984)	3.05559764
68	cellular component biogenesis (GO:0044085)	3.05466418
69	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.05071132
70	hydrogen ion transmembrane transport (GO:1902600)	2.99963620
71	ncRNA catabolic process (GO:0034661)	2.99401070
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.92698866
73	seminiferous tubule development (GO:0072520)	2.91820082
74	acrosome reaction (GO:0007340)	2.88470952
75	piRNA metabolic process (GO:0034587)	2.88424386
76	response to interferon-beta (GO:0035456)	2.87433120
77	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.87161372
78	peptidyl-histidine modification (GO:0018202)	2.84400329
79	protein-cofactor linkage (GO:0018065)	2.84305351
80	proton transport (GO:0015992)	2.84201195
81	respiratory electron transport chain (GO:0022904)	2.83600384
82	electron transport chain (GO:0022900)	2.80560232
83	protein targeting to Golgi (GO:0000042)	2.79076880
84	regulation of T cell chemotaxis (GO:0010819)	2.78243873
85	positive regulation of T cell chemotaxis (GO:0010820)	2.78243873
86	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.77821619
87	regulation of interleukin-8 secretion (GO:2000482)	2.77691620
88	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.77177525
89	hydrogen transport (GO:0006818)	2.75953179
90	microtubule depolymerization (GO:0007019)	2.75150328
91	male meiosis (GO:0007140)	2.72895485
92	pyrimidine-containing compound catabolic process (GO:0072529)	2.71880628
93	regulation of T cell receptor signaling pathway (GO:0050856)	2.71030464
94	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.70757628
95	ATP hydrolysis coupled proton transport (GO:0015991)	2.70757628
96	eosinophil chemotaxis (GO:0048245)	2.70653161
97	protein targeting to membrane (GO:0006612)	2.69010267
98	establishment of protein localization to Golgi (GO:0072600)	2.68669572
99	respiratory chain complex IV assembly (GO:0008535)	2.67800578
100	positive regulation of prostaglandin secretion (GO:0032308)	2.66573118

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.33975322
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.25423854
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.02336794
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.89261101
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.13576478
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84415886
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.81382111
8	VDR_22108803_ChIP-Seq_LS180_Human	2.76758557
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.73480021
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.58385293
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.53539622
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.49797046
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46526337
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.45668888
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.24841541
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18781024
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.17900306
18	TP53_22573176_ChIP-Seq_HFKS_Human	2.01256323
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91562468
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89585366
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79848193
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.75979042
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.70621087
24	FUS_26573619_Chip-Seq_HEK293_Human	1.65974690
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.64080393
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.63121008
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59562278
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.58249190
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51616929
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51326491
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48355600
32	GATA3_26560356_Chip-Seq_TH2_Human	1.44939175
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42422390
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40741924
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38659279
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.37343484
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35076571
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.34001601
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.30250876
40	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.29074430
41	MYC_19829295_ChIP-Seq_ESCs_Human	1.28398278
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.28205887
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28205887
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.26230652
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.24852159
46	NANOG_20526341_ChIP-Seq_ESCs_Human	1.23593248
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.22169984
48	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22168240
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21155941
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21155941
51	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.20103651
52	ERA_21632823_ChIP-Seq_H3396_Human	1.19771385
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19077563
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19077563
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19047158
56	EWS_26573619_Chip-Seq_HEK293_Human	1.18363160
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18354758
58	P300_19829295_ChIP-Seq_ESCs_Human	1.17849146
59	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.17829399
60	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.17584508
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17111819
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.16147946
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.15203250
64	AR_20517297_ChIP-Seq_VCAP_Human	1.15185346
65	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.15104451
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15051365
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14541188
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12702491
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11653713
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10725392
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07215522
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05494676
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04984270
74	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04030515
75	NCOR_22424771_ChIP-Seq_293T_Human	1.03466331
76	GABP_19822575_ChIP-Seq_HepG2_Human	1.02865920
77	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.02420173
78	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.02177552
79	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01831808
80	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01573235
81	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.01566207
82	GATA3_26560356_Chip-Seq_TH1_Human	1.01183075
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01134803
84	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00471769
85	RAC3_21632823_ChIP-Seq_H3396_Human	0.99949049
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99828948
87	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97377210
88	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.97068590
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96663907
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96130419
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95111585
92	MYB_26560356_Chip-Seq_TH2_Human	0.94867378
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94499845
94	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94476330
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92954768
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.92510808
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91985533
98	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.91289545
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91098259
100	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.90532030

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.73927758
2	MP0005377_hearing/vestibular/ear_phenot	3.72192237
3	MP0003878_abnormal_ear_physiology	3.72192237
4	MP0005671_abnormal_response_to	3.28247799
5	MP0005410_abnormal_fertilization	3.07841570
6	MP0006292_abnormal_olfactory_placode	2.93318936
7	MP0002837_dystrophic_cardiac_calcinosis	2.40576626
8	MP0000372_irregular_coat_pigmentation	2.39159499
9	MP0006072_abnormal_retinal_apoptosis	2.38657408
10	MP0009379_abnormal_foot_pigmentation	2.37917097
11	MP0002163_abnormal_gland_morphology	2.24854989
12	MP0008877_abnormal_DNA_methylation	2.23637058
13	MP0004147_increased_porphyrin_level	2.21420336
14	MP0001986_abnormal_taste_sensitivity	2.16364424
15	MP0005379_endocrine/exocrine_gland_phen	2.10485063
16	MP0002638_abnormal_pupillary_reflex	1.85962485
17	MP0001835_abnormal_antigen_presentation	1.85832959
18	MP0005645_abnormal_hypothalamus_physiol	1.85347577
19	MP0005253_abnormal_eye_physiology	1.83321823
20	MP0002653_abnormal_ependyma_morphology	1.82990930
21	MP0005551_abnormal_eye_electrophysiolog	1.67711515
22	MP0005670_abnormal_white_adipose	1.64974977
23	MP0009785_altered_susceptibility_to	1.52574197
24	MP0005332_abnormal_amino_acid	1.52356497
25	MP0001800_abnormal_humoral_immune	1.50501609
26	MP0004142_abnormal_muscle_tone	1.49441114
27	MP0002736_abnormal_nociception_after	1.48691029
28	MP0002102_abnormal_ear_morphology	1.45632629
29	MP0003186_abnormal_redox_activity	1.44678130
30	MP0001968_abnormal_touch/_nociception	1.42809529
31	MP0002723_abnormal_immune_serum	1.41935168
32	MP0003045_fibrosis	1.40362998
33	MP0001984_abnormal_olfaction	1.40342785
34	MP0008875_abnormal_xenobiotic_pharmacok	1.37681583
35	MP0002148_abnormal_hypersensitivity_rea	1.34557112
36	MP0000230_abnormal_systemic_arterial	1.33206012
37	MP0008872_abnormal_physiological_respon	1.30929343
38	MP0001905_abnormal_dopamine_level	1.29342841
39	MP0001485_abnormal_pinna_reflex	1.28010787
40	MP0001929_abnormal_gametogenesis	1.25544656
41	MP0002272_abnormal_nervous_system	1.24433738
42	MP0004145_abnormal_muscle_electrophysio	1.15891924
43	MP0003718_maternal_effect	1.12696014
44	MP0003698_abnormal_male_reproductive	1.09374581
45	MP0008775_abnormal_heart_ventricle	1.08062317
46	MP0009697_abnormal_copulation	1.06979492
47	MP0002420_abnormal_adaptive_immunity	1.04456913
48	MP0003011_delayed_dark_adaptation	1.04027553
49	MP0003646_muscle_fatigue	1.03737032
50	MP0009046_muscle_twitch	1.03666234
51	MP0003693_abnormal_embryo_hatching	1.03552426
52	MP0000613_abnormal_salivary_gland	1.03450012
53	MP0003787_abnormal_imprinting	1.02780094
54	MP0001819_abnormal_immune_cell	1.02591632
55	MP0002210_abnormal_sex_determination	1.02478870
56	MP0002452_abnormal_antigen_presenting	1.01488909
57	MP0005636_abnormal_mineral_homeostasis	1.01225174
58	MP0005000_abnormal_immune_tolerance	0.99055212
59	MP0006082_CNS_inflammation	0.97848949
60	MP0002277_abnormal_respiratory_mucosa	0.97754875
61	MP0001765_abnormal_ion_homeostasis	0.97026421
62	MP0003866_abnormal_defecation	0.96744673
63	MP0001501_abnormal_sleep_pattern	0.95951211
64	MP0002733_abnormal_thermal_nociception	0.95509260
65	MP0001764_abnormal_homeostasis	0.94068292
66	MP0004885_abnormal_endolymph	0.93627611
67	MP0006035_abnormal_mitochondrial_morpho	0.93312773
68	MP0003763_abnormal_thymus_physiology	0.93012410
69	MP0006036_abnormal_mitochondrial_physio	0.92001622
70	MP0003283_abnormal_digestive_organ	0.91215274
71	MP0008058_abnormal_DNA_repair	0.90876885
72	MP0005084_abnormal_gallbladder_morpholo	0.88870926
73	MP0003786_premature_aging	0.88342644
74	MP0005025_abnormal_response_to	0.88109743
75	MP0009745_abnormal_behavioral_response	0.86323601
76	MP0002006_tumorigenesis	0.86170340
77	MP0002405_respiratory_system_inflammati	0.85258293
78	MP0001845_abnormal_inflammatory_respons	0.84499171
79	MP0003315_abnormal_perineum_morphology	0.84144851
80	MP0005451_abnormal_body_composition	0.82759323
81	MP0009764_decreased_sensitivity_to	0.81545161
82	MP0002166_altered_tumor_susceptibility	0.80931745
83	MP0008995_early_reproductive_senescence	0.80888036
84	MP0009115_abnormal_fat_cell	0.80885450
85	MP0009643_abnormal_urine_homeostasis	0.80023777
86	MP0004742_abnormal_vestibular_system	0.79790640
87	MP0000653_abnormal_sex_gland	0.79421437
88	MP0000716_abnormal_immune_system	0.79303080
89	MP0008469_abnormal_protein_level	0.79029642
90	MP0001963_abnormal_hearing_physiology	0.78850373
91	MP0000689_abnormal_spleen_morphology	0.77209974
92	MP0001440_abnormal_grooming_behavior	0.76884405
93	MP0002229_neurodegeneration	0.75467002
94	MP0002938_white_spotting	0.75307366
95	MP0003938_abnormal_ear_development	0.74726465
96	MP0001529_abnormal_vocalization	0.74717790
97	MP0005075_abnormal_melanosome_morpholog	0.74276275
98	MP0001486_abnormal_startle_reflex	0.73676230
99	MP0001542_abnormal_bone_strength	0.73659227
100	MP0005391_vision/eye_phenotype	0.73241524

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Elevated erythrocyte sedimentation rate (HP:0003565)	4.22464129
2	3-Methylglutaconic aciduria (HP:0003535)	4.05482540
3	IgG deficiency (HP:0004315)	3.55606435
4	Hepatocellular necrosis (HP:0001404)	3.51279750
5	Reticulocytopenia (HP:0001896)	3.33632882
6	Hepatic necrosis (HP:0002605)	3.30056953
7	Mitochondrial inheritance (HP:0001427)	3.29968702
8	Septo-optic dysplasia (HP:0100842)	3.23099935
9	Acute necrotizing encephalopathy (HP:0006965)	3.16821728
10	Abnormality of midbrain morphology (HP:0002418)	3.14264457
11	Molar tooth sign on MRI (HP:0002419)	3.14264457
12	Abnormal respiratory epithelium morphology (HP:0012253)	3.11032088
13	Abnormal respiratory motile cilium morphology (HP:0005938)	3.11032088
14	Absent/shortened dynein arms (HP:0200106)	3.07167886
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.07167886
16	Severe combined immunodeficiency (HP:0004430)	2.99384044
17	T lymphocytopenia (HP:0005403)	2.98088656
18	Abnormality of the renal cortex (HP:0011035)	2.92651150
19	Recurrent bronchitis (HP:0002837)	2.91950757
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.86824828
21	Nephronophthisis (HP:0000090)	2.83342833
22	Tubulointerstitial nephritis (HP:0001970)	2.80731782
23	Panhypogammaglobulinemia (HP:0003139)	2.80216384
24	Macrocytic anemia (HP:0001972)	2.76350670
25	Renal cortical cysts (HP:0000803)	2.76156827
26	Increased CSF lactate (HP:0002490)	2.75202117
27	Decreased central vision (HP:0007663)	2.75132193
28	Renal Fanconi syndrome (HP:0001994)	2.73231482
29	Chronic hepatic failure (HP:0100626)	2.72382603
30	Stomatitis (HP:0010280)	2.70908900
31	Abnormal ciliary motility (HP:0012262)	2.70807909
32	Hypoplasia of the thymus (HP:0000778)	2.70005564
33	Abnormal respiratory motile cilium physiology (HP:0012261)	2.67879570
34	Abnormal drinking behavior (HP:0030082)	2.65295630
35	Polydipsia (HP:0001959)	2.65295630
36	Abnormality of T cell number (HP:0011839)	2.65138794
37	Acute encephalopathy (HP:0006846)	2.59942586
38	Progressive macrocephaly (HP:0004481)	2.58724016
39	Chronic mucocutaneous candidiasis (HP:0002728)	2.57861806
40	Recurrent cutaneous fungal infections (HP:0011370)	2.57861806
41	Pancreatic fibrosis (HP:0100732)	2.52589989
42	Pancreatic cysts (HP:0001737)	2.51002793
43	Cerebral edema (HP:0002181)	2.49418616
44	Increased hepatocellular lipid droplets (HP:0006565)	2.49214026
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.48977494
46	Lipid accumulation in hepatocytes (HP:0006561)	2.47777185
47	Aplastic anemia (HP:0001915)	2.46409592
48	True hermaphroditism (HP:0010459)	2.45920301
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45541123
50	Thyroiditis (HP:0100646)	2.45152770
51	Encephalitis (HP:0002383)	2.43682549
52	Abnormality of the renal medulla (HP:0100957)	2.41813010
53	Abnormality of cells of the erythroid lineage (HP:0012130)	2.39464422
54	Abnormality of eosinophils (HP:0001879)	2.37297352
55	Congenital stationary night blindness (HP:0007642)	2.36953526
56	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.30106302
57	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.30106302
58	Chronic diarrhea (HP:0002028)	2.29559423
59	Generalized aminoaciduria (HP:0002909)	2.27781557
60	Bronchitis (HP:0012387)	2.27574904
61	Abnormality of lateral ventricle (HP:0030047)	2.27113915
62	Abolished electroretinogram (ERG) (HP:0000550)	2.26383493
63	Agammaglobulinemia (HP:0004432)	2.23499464
64	Stenosis of the external auditory canal (HP:0000402)	2.21157350
65	Abnormality of T cells (HP:0002843)	2.21065902
66	Absent septum pellucidum (HP:0001331)	2.19811312
67	Combined immunodeficiency (HP:0005387)	2.14872013
68	Chronic sinusitis (HP:0011109)	2.13318159
69	Large eyes (HP:0001090)	2.13071826
70	Hypoalbuminemia (HP:0003073)	2.11550507
71	Abnormal albumin level (HP:0012116)	2.11550507
72	Optic nerve hypoplasia (HP:0000609)	2.09619509
73	Abnormal rod and cone electroretinograms (HP:0008323)	2.08296930
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06729792
75	Abnormality of urine glucose concentration (HP:0011016)	2.05521476
76	Glycosuria (HP:0003076)	2.05521476
77	Arthropathy (HP:0003040)	2.05101430
78	J-shaped sella turcica (HP:0002680)	2.04699368
79	Infertility (HP:0000789)	2.04125226
80	Lactic acidosis (HP:0003128)	2.02842583
81	Increased serum lactate (HP:0002151)	1.99343444
82	Type II lissencephaly (HP:0007260)	1.99280533
83	Bronchiectasis (HP:0002110)	1.98353883
84	Medial flaring of the eyebrow (HP:0010747)	1.97048936
85	Pendular nystagmus (HP:0012043)	1.96026399
86	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.95965338
87	Dicarboxylic aciduria (HP:0003215)	1.95965338
88	Abnormality of the prostate (HP:0008775)	1.95611113
89	Abnormality of the renal collecting system (HP:0004742)	1.95586467
90	Optic disc pallor (HP:0000543)	1.93770542
91	Polyuria (HP:0000103)	1.91878656
92	Hypoproteinemia (HP:0003075)	1.91245376
93	Microretrognathia (HP:0000308)	1.90942743
94	Colon cancer (HP:0003003)	1.90185107
95	Exertional dyspnea (HP:0002875)	1.89281262
96	Menstrual irregularities (HP:0000858)	1.87680408
97	Abnormality of renal resorption (HP:0011038)	1.87311630
98	Atonic seizures (HP:0010819)	1.84759281
99	Respiratory failure (HP:0002878)	1.83512842
100	Leukocytosis (HP:0001974)	1.82938807

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.97020268
2	TXK	3.67623924
3	VRK2	3.50847121
4	PLK4	3.34432814
5	EPHA3	3.09180029
6	CDK19	3.05948780
7	CAMKK2	2.27062829
8	TAOK3	2.12887347
9	EIF2AK3	2.11387124
10	VRK1	2.05344457
11	DYRK2	1.98943747
12	INSRR	1.95174553
13	BCKDK	1.90179516
14	PINK1	1.87242748
15	EIF2AK1	1.85322679
16	GRK1	1.80396324
17	ITK	1.62626890
18	MATK	1.60185509
19	KDR	1.52229040
20	TLK1	1.51200590
21	ZAK	1.48140252
22	STK16	1.43252163
23	MAP4K1	1.42667405
24	TEC	1.41191207
25	IKBKB	1.41126364
26	PLK2	1.39724634
27	NUAK1	1.36477317
28	WNK4	1.30855583
29	IRAK1	1.22901262
30	MAP2K2	1.19588585
31	EIF2AK2	1.19523737
32	KIT	1.11948606
33	TIE1	1.09741981
34	TRIM28	1.06450357
35	PIK3CG	1.06244208
36	PRKCQ	1.04784763
37	ADRBK2	1.04102604
38	TAF1	0.98858518
39	NME2	0.97653633
40	BRD4	0.93810631
41	NLK	0.93625926
42	BTK	0.92874713
43	FRK	0.87847405
44	GRK6	0.87154624
45	MAP3K12	0.86018098
46	SYK	0.80673462
47	TYRO3	0.80018413
48	PHKG2	0.74491050
49	PHKG1	0.74491050
50	EPHB1	0.74484206
51	GRK5	0.74363248
52	CSF1R	0.70865086
53	NEK6	0.70125586
54	BRSK2	0.66338415
55	DAPK1	0.65753241
56	WNK3	0.64284885
57	MAP2K6	0.63317278
58	NTRK1	0.62324260
59	PNCK	0.61945619
60	MAP3K11	0.61655572
61	MST4	0.61283765
62	RPS6KA5	0.61126626
63	IRAK4	0.60350673
64	DAPK3	0.60184290
65	BMPR2	0.57701605
66	FLT3	0.56453108
67	CAMK1G	0.55380330
68	PRKCG	0.48568466
69	PLK3	0.46432382
70	LCK	0.45407199
71	LRRK2	0.45226925
72	SMG1	0.42326491
73	CAMK1	0.40840299
74	PRKACA	0.40794616
75	LYN	0.40659128
76	CDK7	0.40531051
77	OXSR1	0.40515319
78	CAMK1D	0.39148090
79	FES	0.38945217
80	DAPK2	0.38656151
81	ILK	0.38541294
82	CSNK1G3	0.37693792
83	IKBKE	0.36152093
84	ATR	0.35974563
85	LIMK1	0.33406295
86	TNIK	0.33295423
87	PIM1	0.32588067
88	PRKCD	0.32297606
89	PRKCE	0.31009570
90	PTK2B	0.30790195
91	CSNK2A2	0.30677352
92	PBK	0.30264289
93	MAP2K7	0.30259713
94	ADRBK1	0.29407057
95	CHUK	0.26949186
96	CSNK1G2	0.25487809
97	PRKCA	0.25341105
98	CSNK1G1	0.24733796
99	CLK1	0.24472216
100	MAPKAPK5	0.23495730

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.19161017
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.96472843
3	Proteasome_Homo sapiens_hsa03050	3.60959175
4	Parkinsons disease_Homo sapiens_hsa05012	3.16069026
5	Primary immunodeficiency_Homo sapiens_hsa05340	3.04369841
6	Protein export_Homo sapiens_hsa03060	2.64364432
7	Huntingtons disease_Homo sapiens_hsa05016	2.28912175
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.12622547
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.00825485
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.95581138
11	Alzheimers disease_Homo sapiens_hsa05010	1.86275678
12	Basal transcription factors_Homo sapiens_hsa03022	1.85409994
13	Propanoate metabolism_Homo sapiens_hsa00640	1.82357774
14	RNA polymerase_Homo sapiens_hsa03020	1.80451366
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.73890342
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.62963206
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62902124
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.51314141
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50798536
20	Homologous recombination_Homo sapiens_hsa03440	1.47291035
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.45017490
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40110883
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.39752581
24	Allograft rejection_Homo sapiens_hsa05330	1.38078456
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36179347
26	RNA degradation_Homo sapiens_hsa03018	1.36092273
27	RNA transport_Homo sapiens_hsa03013	1.31344994
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30812813
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.30584080
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.29574288
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.29437096
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.28413515
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27886761
34	Spliceosome_Homo sapiens_hsa03040	1.27377436
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16741614
36	Sulfur metabolism_Homo sapiens_hsa00920	1.15657670
37	Asthma_Homo sapiens_hsa05310	1.15622321
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.15139190
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.11932649
40	Butanoate metabolism_Homo sapiens_hsa00650	1.05394944
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04230517
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03756460
43	Fatty acid degradation_Homo sapiens_hsa00071	1.03413222
44	Regulation of autophagy_Homo sapiens_hsa04140	1.01447831
45	Peroxisome_Homo sapiens_hsa04146	0.99500340
46	Phototransduction_Homo sapiens_hsa04744	0.99452502
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98173899
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.97528767
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.96624311
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87444435
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.85899478
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85215475
53	Nicotine addiction_Homo sapiens_hsa05033	0.84580876
54	Mismatch repair_Homo sapiens_hsa03430	0.84497773
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.83423485
56	Purine metabolism_Homo sapiens_hsa00230	0.83230332
57	Base excision repair_Homo sapiens_hsa03410	0.81859609
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81810694
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.80828952
60	DNA replication_Homo sapiens_hsa03030	0.80520249
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79292341
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.78582624
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78437389
64	Olfactory transduction_Homo sapiens_hsa04740	0.76135034
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75484582
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71146185
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.67669671
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66247013
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62582650
70	Taste transduction_Homo sapiens_hsa04742	0.62290542
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60923928
72	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60747937
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59481269
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.56645206
75	Caffeine metabolism_Homo sapiens_hsa00232	0.55523497
76	Morphine addiction_Homo sapiens_hsa05032	0.53319037
77	Metabolic pathways_Homo sapiens_hsa01100	0.51855246
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50471902
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50211463
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49963978
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48563276
82	Glutathione metabolism_Homo sapiens_hsa00480	0.44596669
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44383129
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43524922
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.43119071
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41171309
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37673759
88	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.36348812
89	One carbon pool by folate_Homo sapiens_hsa00670	0.33982553
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.33271158
91	Retinol metabolism_Homo sapiens_hsa00830	0.33001799
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.31582273
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24094763
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.23375483
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.23366704
96	Salivary secretion_Homo sapiens_hsa04970	0.23288096
97	Measles_Homo sapiens_hsa05162	0.21504016
98	Viral myocarditis_Homo sapiens_hsa05416	0.20340746
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.20060823
100	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.19829879

RPL12P26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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