RPL12P27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.59907667
2viral transcription (GO:0019083)6.34976281
3translational termination (GO:0006415)6.04945598
4ATP synthesis coupled proton transport (GO:0015986)5.78597456
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.78597456
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.52920260
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.37713760
8protein targeting to ER (GO:0045047)5.27498749
9translational elongation (GO:0006414)5.26835143
10cotranslational protein targeting to membrane (GO:0006613)5.26586558
11DNA deamination (GO:0045006)5.25738551
12ribosomal small subunit biogenesis (GO:0042274)5.16853858
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.02493048
14protein localization to endoplasmic reticulum (GO:0070972)4.96819883
15maturation of SSU-rRNA (GO:0030490)4.77392217
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.69116689
17cellular protein complex disassembly (GO:0043624)4.57307940
18viral life cycle (GO:0019058)4.56767200
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.46293925
20respiratory electron transport chain (GO:0022904)4.35092710
21electron transport chain (GO:0022900)4.34153177
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25100931
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23469162
24chaperone-mediated protein transport (GO:0072321)4.23312100
25translational initiation (GO:0006413)4.09544042
26cytidine deamination (GO:0009972)4.02656346
27cytidine metabolic process (GO:0046087)4.02656346
28cytidine catabolic process (GO:0006216)4.02656346
29regulation of regulatory T cell differentiation (GO:0045589)3.75948641
30protein complex disassembly (GO:0043241)3.69423182
31protein neddylation (GO:0045116)3.65456314
32translation (GO:0006412)3.64041499
33protein complex biogenesis (GO:0070271)3.62039377
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.59394508
35pyrimidine ribonucleoside catabolic process (GO:0046133)3.58472662
36base-excision repair, AP site formation (GO:0006285)3.57089564
37positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.54283422
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52582632
39ATP biosynthetic process (GO:0006754)3.48457612
40peptidyl-histidine modification (GO:0018202)3.47823028
41macromolecular complex disassembly (GO:0032984)3.45612593
42cytochrome complex assembly (GO:0017004)3.43485635
43respiratory chain complex IV assembly (GO:0008535)3.40796784
44protein targeting to membrane (GO:0006612)3.39143431
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38668289
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.38068701
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37716345
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37716345
49regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.27330613
50positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26955077
51mitochondrial respiratory chain complex assembly (GO:0033108)3.22960038
52regulation of isotype switching to IgG isotypes (GO:0048302)3.22880659
53pyrimidine nucleotide catabolic process (GO:0006244)3.15108397
54deoxyribonucleotide catabolic process (GO:0009264)3.15070414
55ribosomal large subunit biogenesis (GO:0042273)3.14266329
56hydrogen ion transmembrane transport (GO:1902600)3.12979102
57cellular response to interleukin-15 (GO:0071350)3.08085411
58GTP biosynthetic process (GO:0006183)3.07668764
59negative T cell selection (GO:0043383)3.04701071
60purine deoxyribonucleotide catabolic process (GO:0009155)3.01823463
61nuclear-transcribed mRNA catabolic process (GO:0000956)3.01501921
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.01190084
63NADH dehydrogenase complex assembly (GO:0010257)3.01190084
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01190084
65regulation of T cell mediated cytotoxicity (GO:0001914)3.00702928
66deoxyribose phosphate catabolic process (GO:0046386)3.00111293
67positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.98326508
68platelet dense granule organization (GO:0060155)2.96520541
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93475621
70sequestering of actin monomers (GO:0042989)2.93412887
71positive regulation of respiratory burst (GO:0060267)2.92422046
72positive regulation of tolerance induction (GO:0002645)2.89969651
73positive T cell selection (GO:0043368)2.87125797
74proton transport (GO:0015992)2.86616562
75mRNA catabolic process (GO:0006402)2.84673875
76water-soluble vitamin biosynthetic process (GO:0042364)2.83783487
77regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82371657
78preassembly of GPI anchor in ER membrane (GO:0016254)2.82043975
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81126783
80hydrogen transport (GO:0006818)2.79647949
81cellular component biogenesis (GO:0044085)2.73771497
82positive regulation of cell killing (GO:0031343)2.69714260
83ribonucleoprotein complex biogenesis (GO:0022613)2.65847537
84behavioral response to nicotine (GO:0035095)2.64966395
85positive thymic T cell selection (GO:0045059)2.63939835
86regulation of T cell tolerance induction (GO:0002664)2.61537707
87RNA catabolic process (GO:0006401)2.59060905
88positive regulation of defense response to virus by host (GO:0002230)2.58722915
89regulation of cell killing (GO:0031341)2.58673038
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.56365057
91rRNA metabolic process (GO:0016072)2.56264041
92rRNA processing (GO:0006364)2.56086818
93regulation of T cell receptor signaling pathway (GO:0050856)2.55792242
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53841325
95negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49065562
96negative regulation of cell killing (GO:0031342)2.49065562
97intracellular protein transmembrane import (GO:0044743)2.48909802
98regulation of immunoglobulin secretion (GO:0051023)2.47612071
99pseudouridine synthesis (GO:0001522)2.47550293
100protein targeting to mitochondrion (GO:0006626)2.46628156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.17310817
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.63763580
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.27626147
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.89686393
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68719247
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.67454792
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61217114
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58664600
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43973038
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.40278663
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37435953
12VDR_23849224_ChIP-Seq_CD4+_Human2.33855401
13ZNF274_21170338_ChIP-Seq_K562_Hela2.26191293
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25060369
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20286266
16EZH2_22144423_ChIP-Seq_EOC_Human2.14072903
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12369678
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08145988
19VDR_22108803_ChIP-Seq_LS180_Human2.00328649
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90914906
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90722063
22FOXP3_21729870_ChIP-Seq_TREG_Human1.86137128
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.72811626
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.70937317
25ELK1_19687146_ChIP-ChIP_HELA_Human1.70645208
26TP53_22573176_ChIP-Seq_HFKS_Human1.66810221
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66120538
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.57947088
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57841563
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53651377
31NANOG_20526341_ChIP-Seq_ESCs_Human1.52346848
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.51170715
33PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.48743033
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45372173
35GATA3_26560356_Chip-Seq_TH2_Human1.43724304
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41905537
37AR_20517297_ChIP-Seq_VCAP_Human1.40905085
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.39349411
39MYB_26560356_Chip-Seq_TH2_Human1.39181288
40PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37332375
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36139012
42IRF1_19129219_ChIP-ChIP_H3396_Human1.33753586
43BCL6_27268052_Chip-Seq_Bcells_Human1.33288568
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32899853
45STAT1_20625510_ChIP-Seq_HELA_Human1.32525968
46P300_27268052_Chip-Seq_Bcells_Human1.30807250
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30806710
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30225539
49TAF2_19829295_ChIP-Seq_ESCs_Human1.30096424
50NCOR_22424771_ChIP-Seq_293T_Human1.28816997
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.28699478
52MYC_19829295_ChIP-Seq_ESCs_Human1.27042640
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26489537
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.26489537
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.24817828
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24411328
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24136651
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24085281
59RUNX_20019798_ChIP-Seq_JUKART_Human1.24060804
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21927216
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21373285
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20873968
63ERG_20517297_ChIP-Seq_VCAP_Human1.20516949
64CTCF_20526341_ChIP-Seq_ESCs_Human1.19770262
65GATA3_27048872_Chip-Seq_THYMUS_Human1.18246351
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17892641
67MYC_18940864_ChIP-ChIP_HL60_Human1.17875680
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16409010
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15624561
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.15497179
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14600320
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.14309840
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14274468
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.13902903
75ERA_21632823_ChIP-Seq_H3396_Human1.11029047
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10326659
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09798404
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09499437
79E2F1_20622854_ChIP-Seq_HELA_Human1.09003708
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07828306
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06742514
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06235677
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05394181
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04350169
85NANOG_19829295_ChIP-Seq_ESCs_Human1.03959896
86SOX2_19829295_ChIP-Seq_ESCs_Human1.03959896
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02058318
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01651876
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01411097
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00504976
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97392870
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.96468529
93RAC3_21632823_ChIP-Seq_H3396_Human0.96221626
94CTCF_26484167_Chip-Seq_Bcells_Mouse0.96112754
95HTT_18923047_ChIP-ChIP_STHdh_Human0.95927026
96GATA3_21867929_ChIP-Seq_TH1_Mouse0.95426418
97TTF2_22483619_ChIP-Seq_HELA_Human0.94323041
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.94045318
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93867810
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93341488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.17850215
2MP0005671_abnormal_response_to4.02405802
3MP0001835_abnormal_antigen_presentation3.05523337
4MP0006292_abnormal_olfactory_placode2.66395184
5MP0005377_hearing/vestibular/ear_phenot2.47637270
6MP0003878_abnormal_ear_physiology2.47637270
7MP0003011_delayed_dark_adaptation2.26068049
8MP0003646_muscle_fatigue2.26016096
9MP0009785_altered_susceptibility_to2.24024082
10MP0008872_abnormal_physiological_respon2.11454350
11MP0005646_abnormal_pituitary_gland2.00561364
12MP0002102_abnormal_ear_morphology2.00503173
13MP0000685_abnormal_immune_system1.96247660
14MP0001800_abnormal_humoral_immune1.91761931
15MP0002163_abnormal_gland_morphology1.91063214
16MP0005000_abnormal_immune_tolerance1.90968299
17MP0005387_immune_system_phenotype1.90225401
18MP0001790_abnormal_immune_system1.90225401
19MP0008877_abnormal_DNA_methylation1.89656735
20MP0006072_abnormal_retinal_apoptosis1.89402123
21MP0003763_abnormal_thymus_physiology1.88997375
22MP0002148_abnormal_hypersensitivity_rea1.88401968
23MP0004147_increased_porphyrin_level1.86833738
24MP0002277_abnormal_respiratory_mucosa1.83042493
25MP0001986_abnormal_taste_sensitivity1.82198151
26MP0005670_abnormal_white_adipose1.71234855
27MP0002723_abnormal_immune_serum1.70995290
28MP0001873_stomach_inflammation1.67555232
29MP0005551_abnormal_eye_electrophysiolog1.67043458
30MP0009333_abnormal_splenocyte_physiolog1.66033704
31MP0002837_dystrophic_cardiac_calcinosis1.65343757
32MP0005025_abnormal_response_to1.61323201
33MP0002420_abnormal_adaptive_immunity1.58331469
34MP0005645_abnormal_hypothalamus_physiol1.56146899
35MP0003436_decreased_susceptibility_to1.54185035
36MP0003786_premature_aging1.54073434
37MP0001819_abnormal_immune_cell1.54070578
38MP0005379_endocrine/exocrine_gland_phen1.52628938
39MP0004885_abnormal_endolymph1.49796597
40MP0003195_calcinosis1.49089654
41MP0002876_abnormal_thyroid_physiology1.48608379
42MP0003866_abnormal_defecation1.40525810
43MP0005075_abnormal_melanosome_morpholog1.35470805
44MP0003724_increased_susceptibility_to1.34164078
45MP0003806_abnormal_nucleotide_metabolis1.33222316
46MP0002166_altered_tumor_susceptibility1.32668126
47MP0005360_urolithiasis1.30613190
48MP0001919_abnormal_reproductive_system1.29805955
49MP0010155_abnormal_intestine_physiology1.28169696
50MP0002452_abnormal_antigen_presenting1.28038259
51MP0008875_abnormal_xenobiotic_pharmacok1.27861437
52MP0001845_abnormal_inflammatory_respons1.25671350
53MP0005174_abnormal_tail_pigmentation1.21096817
54MP0005085_abnormal_gallbladder_physiolo1.18283852
55MP0002095_abnormal_skin_pigmentation1.15250651
56MP0002405_respiratory_system_inflammati1.14191063
57MP0000716_abnormal_immune_system1.13002849
58MP0009764_decreased_sensitivity_to1.11624899
59MP0002006_tumorigenesis1.10275457
60MP0006036_abnormal_mitochondrial_physio1.10057210
61MP0004145_abnormal_muscle_electrophysio1.10006145
62MP0005410_abnormal_fertilization1.09381817
63MP0008789_abnormal_olfactory_epithelium1.09075900
64MP0001663_abnormal_digestive_system1.07677269
65MP0005636_abnormal_mineral_homeostasis1.05864376
66MP0005389_reproductive_system_phenotype1.05818636
67MP0005253_abnormal_eye_physiology1.05666523
68MP0001765_abnormal_ion_homeostasis1.03742701
69MP0002398_abnormal_bone_marrow1.02336377
70MP0000689_abnormal_spleen_morphology1.01130327
71MP0003879_abnormal_hair_cell1.00914897
72MP0001905_abnormal_dopamine_level0.99909606
73MP0002736_abnormal_nociception_after0.98810583
74MP0005084_abnormal_gallbladder_morpholo0.96856153
75MP0002933_joint_inflammation0.95187678
76MP0002693_abnormal_pancreas_physiology0.94210061
77MP0001853_heart_inflammation0.93668489
78MP0004142_abnormal_muscle_tone0.92100278
79MP0001968_abnormal_touch/_nociception0.91406993
80MP0001501_abnormal_sleep_pattern0.90018580
81MP0008469_abnormal_protein_level0.89847198
82MP0001485_abnormal_pinna_reflex0.89057788
83MP0002138_abnormal_hepatobiliary_system0.87504025
84MP0003252_abnormal_bile_duct0.86580103
85MP0000631_abnormal_neuroendocrine_gland0.85361297
86MP0005332_abnormal_amino_acid0.85249797
87MP0002429_abnormal_blood_cell0.85210487
88MP0008995_early_reproductive_senescence0.82717059
89MP0002722_abnormal_immune_system0.81707224
90MP0002419_abnormal_innate_immunity0.81186008
91MP0000703_abnormal_thymus_morphology0.80138875
92MP0005408_hypopigmentation0.77090474
93MP0004019_abnormal_vitamin_homeostasis0.76802225
94MP0010329_abnormal_lipoprotein_level0.76430332
95MP0004043_abnormal_pH_regulation0.76353207
96MP0002272_abnormal_nervous_system0.75427194
97MP0002160_abnormal_reproductive_system0.75379379
98MP0001293_anophthalmia0.74602319
99MP0003638_abnormal_response/metabolism_0.73054286
100MP0009643_abnormal_urine_homeostasis0.71456926

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.46061099
2Mitochondrial inheritance (HP:0001427)4.40161480
3Acute necrotizing encephalopathy (HP:0006965)4.22962094
4Hepatocellular necrosis (HP:0001404)3.90172000
5Abnormal mitochondria in muscle tissue (HP:0008316)3.89003892
6Congenital stationary night blindness (HP:0007642)3.80467222
7Increased CSF lactate (HP:0002490)3.73705553
8Increased hepatocellular lipid droplets (HP:0006565)3.72033431
9Acute encephalopathy (HP:0006846)3.71522407
10Hepatic necrosis (HP:0002605)3.66355176
11IgG deficiency (HP:0004315)3.61486155
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.54321913
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.54321913
14Progressive macrocephaly (HP:0004481)3.54235165
15Increased muscle lipid content (HP:0009058)3.53883808
16Stomatitis (HP:0010280)3.44746010
17Reticulocytopenia (HP:0001896)3.43208994
18Abnormality of cells of the erythroid lineage (HP:0012130)3.35789477
19Renal Fanconi syndrome (HP:0001994)3.35136165
20Increased intramyocellular lipid droplets (HP:0012240)3.20459274
21Colon cancer (HP:0003003)3.19086385
22Abnormal number of erythroid precursors (HP:0012131)3.18999713
23Increased IgM level (HP:0003496)3.13937942
24Macrocytic anemia (HP:0001972)3.12559712
253-Methylglutaconic aciduria (HP:0003535)2.90260465
26Aplastic anemia (HP:0001915)2.88123714
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84577165
28Elevated erythrocyte sedimentation rate (HP:0003565)2.83230546
29Pancreatic cysts (HP:0001737)2.77466636
30Cerebral edema (HP:0002181)2.69481869
31Exertional dyspnea (HP:0002875)2.65564241
32Severe combined immunodeficiency (HP:0004430)2.64795978
33Abnormality of urine glucose concentration (HP:0011016)2.59582612
34Glycosuria (HP:0003076)2.59582612
35Lactic acidosis (HP:0003128)2.56899979
36Methylmalonic aciduria (HP:0012120)2.55846071
37Respiratory failure (HP:0002878)2.52814347
38Abnormality of T cells (HP:0002843)2.50680961
39Optic disc pallor (HP:0000543)2.49643074
40Generalized aminoaciduria (HP:0002909)2.46953108
41Pallor (HP:0000980)2.46768928
42Abnormal rod and cone electroretinograms (HP:0008323)2.45558845
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44781642
44Pancreatic fibrosis (HP:0100732)2.44523930
45Methylmalonic acidemia (HP:0002912)2.42976297
46Renal cortical cysts (HP:0000803)2.38179987
47Congenital, generalized hypertrichosis (HP:0004540)2.36569328
48Abnormality of T cell number (HP:0011839)2.35562798
49Abnormality of the renal cortex (HP:0011035)2.34429301
50Abnormality of T cell physiology (HP:0011840)2.29750137
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.29277414
52Decreased central vision (HP:0007663)2.29256495
53Stomach cancer (HP:0012126)2.27132724
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26902446
55Absent thumb (HP:0009777)2.26277707
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25994354
57Attenuation of retinal blood vessels (HP:0007843)2.23413830
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.22265724
59Absent/shortened dynein arms (HP:0200106)2.22265724
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22254974
61T lymphocytopenia (HP:0005403)2.21872518
62Increased serum lactate (HP:0002151)2.21858471
63Polydipsia (HP:0001959)2.21794625
64Abnormal drinking behavior (HP:0030082)2.21794625
65Molar tooth sign on MRI (HP:0002419)2.21775072
66Abnormality of midbrain morphology (HP:0002418)2.21775072
67True hermaphroditism (HP:0010459)2.16738863
68Dicarboxylic aciduria (HP:0003215)2.16370058
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16370058
70Lethargy (HP:0001254)2.15529283
71Panhypogammaglobulinemia (HP:0003139)2.15369841
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13799727
73Abnormality of eosinophils (HP:0001879)2.06668434
74Abnormality of renal resorption (HP:0011038)2.06171946
75Hyperphosphaturia (HP:0003109)2.05190991
76Thyroiditis (HP:0100646)2.05089633
77Abnormality of magnesium homeostasis (HP:0004921)1.98880189
78Autoimmune hemolytic anemia (HP:0001890)1.97257323
79Combined immunodeficiency (HP:0005387)1.97242967
80Abnormal respiratory motile cilium physiology (HP:0012261)1.95013719
81Pancytopenia (HP:0001876)1.94823036
82Respiratory difficulties (HP:0002880)1.93974890
83Abolished electroretinogram (ERG) (HP:0000550)1.93014338
84Nephronophthisis (HP:0000090)1.90438955
85Hypoproteinemia (HP:0003075)1.89519467
86Encephalitis (HP:0002383)1.87534022
87Abnormal ciliary motility (HP:0012262)1.84659639
88Polyuria (HP:0000103)1.83236419
89Hyperglycinemia (HP:0002154)1.80712303
90Hypomagnesemia (HP:0002917)1.80446656
91Severe visual impairment (HP:0001141)1.80307742
92Neutropenia (HP:0001875)1.78991662
93Leukodystrophy (HP:0002415)1.76993000
94Exercise intolerance (HP:0003546)1.76325000
95Chronic bronchitis (HP:0004469)1.74086909
96Abnormality of vitamin B metabolism (HP:0004340)1.73777155
97Eosinophilia (HP:0001880)1.73255417
98Abnormality of the prostate (HP:0008775)1.72901144
99Abnormal albumin level (HP:0012116)1.71195661
100Hypoalbuminemia (HP:0003073)1.71195661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.67324267
2KDR3.74534003
3TESK22.96896513
4BCKDK2.82146309
5CDK192.77259357
6ADRBK22.68769330
7MAP4K22.54733264
8TLK12.44693371
9PASK2.36880133
10WNK42.31401199
11GRK12.19795455
12MAP4K11.97331424
13MUSK1.92004597
14PINK11.89631022
15NUAK11.84173987
16ZAK1.83313063
17FRK1.78858110
18VRK21.72418047
19IKBKE1.67331984
20TAOK31.66325009
21MAP2K21.62471071
22NME11.56430610
23NME21.55100172
24ERN11.54296517
25IKBKB1.53346613
26LRRK21.50746523
27ITK1.50166718
28INSRR1.34592470
29TEC1.33734738
30STK161.28573048
31LIMK11.26685423
32STK391.23338184
33GRK61.21156403
34PLK41.20258897
35DYRK21.19704557
36SYK1.18254628
37ADRBK11.16947738
38OXSR11.16369924
39BUB11.10028258
40MAP2K61.08762379
41MAP3K121.04298565
42FES1.01894601
43BTK1.01466443
44TBK10.99285011
45MST40.98059676
46PRKCQ0.90882925
47KIT0.89517114
48LCK0.89347373
49CAMKK10.87987489
50RPS6KA50.87384282
51CAMKK20.87215528
52WNK30.83161779
53VRK10.82817154
54LYN0.82189083
55ACVR1B0.79854871
56TIE10.76446498
57MAP3K110.75656375
58DAPK20.72022605
59PIK3CA0.71989172
60CSF1R0.70574544
61CSNK1G30.69291740
62NLK0.66565293
63MYLK0.62318152
64GRK70.62076381
65CSK0.61722561
66OBSCN0.60385397
67PIK3CG0.59093786
68STK110.56634053
69ZAP700.55648932
70PHKG10.54180167
71PHKG20.54180167
72JAK30.53863376
73DAPK10.53040062
74CSNK2A20.50774965
75MAPKAPK30.49452847
76EIF2AK30.48214908
77CSNK1G10.47310460
78PRKCA0.47210789
79CSNK1G20.47032668
80PRKACA0.45657323
81TYK20.43642714
82TESK10.43411373
83IGF1R0.42893970
84CSNK2A10.42066304
85TNK20.41660364
86CSNK1A1L0.41660029
87CAMK10.40256171
88MAPK130.39938622
89GRK50.39276567
90PIM10.37595100
91MARK30.36335883
92PIM20.34870541
93TRIM280.34701692
94HCK0.34404975
95MAPK150.30850476
96CSNK1A10.29603289
97ILK0.27949327
98RPS6KA60.27852377
99DAPK30.27580026
100ROCK10.26551529

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.10277269
2Oxidative phosphorylation_Homo sapiens_hsa001904.10328588
3Primary immunodeficiency_Homo sapiens_hsa053403.42355776
4Parkinsons disease_Homo sapiens_hsa050123.31749955
5Allograft rejection_Homo sapiens_hsa053302.74750298
6Asthma_Homo sapiens_hsa053102.72015779
7Autoimmune thyroid disease_Homo sapiens_hsa053202.65228897
8Proteasome_Homo sapiens_hsa030502.56827180
9Graft-versus-host disease_Homo sapiens_hsa053322.55535376
10Type I diabetes mellitus_Homo sapiens_hsa049402.41662274
11Alzheimers disease_Homo sapiens_hsa050102.29793204
12Huntingtons disease_Homo sapiens_hsa050162.18339857
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.12148198
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10412954
15Cardiac muscle contraction_Homo sapiens_hsa042601.85143582
16Protein export_Homo sapiens_hsa030601.79810866
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78470504
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77512828
19RNA polymerase_Homo sapiens_hsa030201.73599797
20Antigen processing and presentation_Homo sapiens_hsa046121.69071559
21Homologous recombination_Homo sapiens_hsa034401.68940302
22Hematopoietic cell lineage_Homo sapiens_hsa046401.63005258
23Linoleic acid metabolism_Homo sapiens_hsa005911.52677736
24Phototransduction_Homo sapiens_hsa047441.47824516
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38374817
26Rheumatoid arthritis_Homo sapiens_hsa053231.27887651
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25690484
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20645058
29Nitrogen metabolism_Homo sapiens_hsa009101.17525269
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12928025
31Pyrimidine metabolism_Homo sapiens_hsa002401.09286719
32Viral myocarditis_Homo sapiens_hsa054161.06510698
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03342721
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03125691
35Sulfur relay system_Homo sapiens_hsa041220.97020091
36T cell receptor signaling pathway_Homo sapiens_hsa046600.93644968
37Fat digestion and absorption_Homo sapiens_hsa049750.93296751
38Mismatch repair_Homo sapiens_hsa034300.91864069
39Primary bile acid biosynthesis_Homo sapiens_hsa001200.91551241
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90075367
41Caffeine metabolism_Homo sapiens_hsa002320.89595972
42RNA degradation_Homo sapiens_hsa030180.89042188
43DNA replication_Homo sapiens_hsa030300.88667078
44Retinol metabolism_Homo sapiens_hsa008300.88406255
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87665716
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.84799030
47Arachidonic acid metabolism_Homo sapiens_hsa005900.84660346
48Fanconi anemia pathway_Homo sapiens_hsa034600.81546278
49Base excision repair_Homo sapiens_hsa034100.80656185
50Nucleotide excision repair_Homo sapiens_hsa034200.78966293
51Staphylococcus aureus infection_Homo sapiens_hsa051500.76741765
52Peroxisome_Homo sapiens_hsa041460.76716334
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76622425
54Purine metabolism_Homo sapiens_hsa002300.74635380
55Propanoate metabolism_Homo sapiens_hsa006400.71619050
56Chemical carcinogenesis_Homo sapiens_hsa052040.71156939
57Tryptophan metabolism_Homo sapiens_hsa003800.69910639
58Butanoate metabolism_Homo sapiens_hsa006500.67370596
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67144090
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.65790707
61One carbon pool by folate_Homo sapiens_hsa006700.65712329
62Olfactory transduction_Homo sapiens_hsa047400.65660729
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62615101
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56406584
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56039413
66Metabolic pathways_Homo sapiens_hsa011000.54537180
67Basal transcription factors_Homo sapiens_hsa030220.54120591
68Vitamin digestion and absorption_Homo sapiens_hsa049770.52468547
69Collecting duct acid secretion_Homo sapiens_hsa049660.51625615
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.51306056
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.51076113
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50548831
73Malaria_Homo sapiens_hsa051440.50177328
74Systemic lupus erythematosus_Homo sapiens_hsa053220.50163127
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48543868
76Sulfur metabolism_Homo sapiens_hsa009200.47637305
77Mineral absorption_Homo sapiens_hsa049780.47320515
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47139148
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46253808
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43030427
81Spliceosome_Homo sapiens_hsa030400.41349942
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40943894
83Ether lipid metabolism_Homo sapiens_hsa005650.36676794
84Nicotine addiction_Homo sapiens_hsa050330.34284660
85Measles_Homo sapiens_hsa051620.33842895
86Morphine addiction_Homo sapiens_hsa050320.33719782
87Leishmaniasis_Homo sapiens_hsa051400.32288920
88RNA transport_Homo sapiens_hsa030130.31980780
89Fatty acid degradation_Homo sapiens_hsa000710.30723885
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30455449
91Serotonergic synapse_Homo sapiens_hsa047260.28394229
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28107012
93Taste transduction_Homo sapiens_hsa047420.27030209
94Herpes simplex infection_Homo sapiens_hsa051680.26364213
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26360156
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21880207
97Salivary secretion_Homo sapiens_hsa049700.21734587
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.21562891
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20875207
100Renin-angiotensin system_Homo sapiens_hsa046140.20511166

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