ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.76435476
2	somite development (GO:0061053)	4.72746393
3	neuron fate determination (GO:0048664)	4.48267444
4	viral transcription (GO:0019083)	4.25802130
5	positive regulation of prostaglandin secretion (GO:0032308)	4.16583346
6	translational termination (GO:0006415)	4.07828114
7	dendritic spine morphogenesis (GO:0060997)	4.07519077
8	nucleobase catabolic process (GO:0046113)	3.97940432
9	chemosensory behavior (GO:0007635)	3.92603461
10	positive regulation of vascular permeability (GO:0043117)	3.85458738
11	auditory receptor cell differentiation (GO:0042491)	3.82027361
12	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.79447420
13	substrate-independent telencephalic tangential migration (GO:0021826)	3.79447420
14	cell proliferation in forebrain (GO:0021846)	3.78858687
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.74462340
16	histone arginine methylation (GO:0034969)	3.71302538
17	basic amino acid transport (GO:0015802)	3.65304129
18	radial glial cell differentiation (GO:0060019)	3.61694597
19	response to nitrosative stress (GO:0051409)	3.61083195
20	neuronal stem cell maintenance (GO:0097150)	3.59881182
21	nonmotile primary cilium assembly (GO:0035058)	3.56287020
22	ribosomal small subunit assembly (GO:0000028)	3.54812972
23	vocalization behavior (GO:0071625)	3.52269344
24	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.46721576
25	positive regulation of fatty acid transport (GO:2000193)	3.44030799
26	cotranslational protein targeting to membrane (GO:0006613)	3.42128411
27	astrocyte differentiation (GO:0048708)	3.40944788
28	pyrimidine nucleobase catabolic process (GO:0006208)	3.40490845
29	protein targeting to ER (GO:0045047)	3.40021911
30	central nervous system myelination (GO:0022010)	3.39469440
31	axon ensheathment in central nervous system (GO:0032291)	3.39469440
32	specification of organ identity (GO:0010092)	3.35447628
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.30086606
34	tongue development (GO:0043586)	3.28893090
35	protein localization to endoplasmic reticulum (GO:0070972)	3.26693726
36	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.25925685
37	translational elongation (GO:0006414)	3.24852276
38	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.24607667
39	regulation of prostaglandin secretion (GO:0032306)	3.22214376
40	spinal cord motor neuron differentiation (GO:0021522)	3.18297986
41	DNA methylation involved in gamete generation (GO:0043046)	3.15355367
42	protein complex biogenesis (GO:0070271)	3.14186023
43	protein localization to cilium (GO:0061512)	3.12374127
44	positive regulation of icosanoid secretion (GO:0032305)	3.11887680
45	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.10745627
46	sulfation (GO:0051923)	3.10438473
47	lipopolysaccharide biosynthetic process (GO:0009103)	3.10196772
48	segment specification (GO:0007379)	3.09114122
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08541165
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.07914797
51	NADH dehydrogenase complex assembly (GO:0010257)	3.07914797
52	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.07914797
53	piRNA metabolic process (GO:0034587)	3.05466797
54	viral life cycle (GO:0019058)	3.05361621
55	nephron epithelium morphogenesis (GO:0072088)	3.03909044
56	nephron tubule morphogenesis (GO:0072078)	3.03909044
57	otic vesicle formation (GO:0030916)	3.03852824
58	retina development in camera-type eye (GO:0060041)	3.00750917
59	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.99863734
60	respiratory chain complex IV assembly (GO:0008535)	2.97156428
61	phosphorelay signal transduction system (GO:0000160)	2.93660281
62	tooth mineralization (GO:0034505)	2.92635777
63	inner ear receptor stereocilium organization (GO:0060122)	2.91836309
64	auditory behavior (GO:0031223)	2.91078432
65	pattern specification involved in kidney development (GO:0061004)	2.90639690
66	axonal fasciculation (GO:0007413)	2.89027889
67	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.87088320
68	cellular protein complex disassembly (GO:0043624)	2.86746084
69	ATP synthesis coupled proton transport (GO:0015986)	2.85572096
70	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.85572096
71	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.82908384
72	intraciliary transport (GO:0042073)	2.80531754
73	cellular anion homeostasis (GO:0030002)	2.80214301
74	behavioral response to ethanol (GO:0048149)	2.76199020
75	telencephalon development (GO:0021537)	2.74443606
76	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.72880146
77	S-adenosylmethionine metabolic process (GO:0046500)	2.70716920
78	seminiferous tubule development (GO:0072520)	2.69224273
79	positive regulation of glycolytic process (GO:0045821)	2.69218749
80	axoneme assembly (GO:0035082)	2.67742949
81	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.67608686
82	cilium morphogenesis (GO:0060271)	2.67187997
83	hindbrain development (GO:0030902)	2.66181833
84	intracellular protein transmembrane import (GO:0044743)	2.64985341
85	multicellular organismal movement (GO:0050879)	2.62319775
86	musculoskeletal movement (GO:0050881)	2.62319775
87	short-term memory (GO:0007614)	2.62257334
88	reciprocal DNA recombination (GO:0035825)	2.61826352
89	reciprocal meiotic recombination (GO:0007131)	2.61826352
90	hypothalamus development (GO:0021854)	2.61817273
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.61785720
92	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.61087450
93	cytochrome complex assembly (GO:0017004)	2.61037797
94	cell differentiation in spinal cord (GO:0021515)	2.59972418
95	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59816290
96	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59816290
97	spinal cord association neuron differentiation (GO:0021527)	2.59503758
98	regulation of penile erection (GO:0060405)	2.58626757
99	centriole replication (GO:0007099)	2.58365214
100	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.57948113

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.79772869
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.94118882
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11928333
4	VDR_22108803_ChIP-Seq_LS180_Human	2.54966831
5	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.48417177
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35000668
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.26889977
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.23688775
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14361027
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10388933
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.07791763
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04185162
13	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.01800925
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.98319176
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.90857035
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.78035015
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75554208
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.73609491
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70774107
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.70317920
21	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.68986014
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.66110720
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.64540532
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63959542
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.59414146
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.57836631
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.57398225
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56098317
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.50714294
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.50543615
31	P300_19829295_ChIP-Seq_ESCs_Human	1.50184330
32	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48962814
33	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.48234121
34	AR_25329375_ChIP-Seq_VCAP_Human	1.46249326
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.44337973
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.43023140
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.41290967
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.37447410
39	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.36605295
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35444684
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.33878892
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32858580
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31326918
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.31326918
45	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.29128226
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28337186
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27761269
48	FUS_26573619_Chip-Seq_HEK293_Human	1.27659783
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27424676
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25836512
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.24109154
52	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.23745423
53	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.22483525
54	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.22019466
55	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20561623
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20024620
57	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18897901
58	RXR_22108803_ChIP-Seq_LS180_Human	1.18297158
59	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.17634338
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.17462894
61	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.17385378
62	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.16530349
63	IGF1R_20145208_ChIP-Seq_DFB_Human	1.16309897
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15582322
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15327312
66	DROSHA_22980978_ChIP-Seq_HELA_Human	1.14380387
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14312936
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13344222
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12730012
70	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.12720297
71	AR_21572438_ChIP-Seq_LNCaP_Human	1.10145562
72	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09167643
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.08360466
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.08177926
75	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.07436926
76	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.07239946
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06404202
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06305390
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05953855
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05248080
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04367879
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04329952
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04218312
84	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.04094700
85	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.03911855
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01696804
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01465584
88	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.99819998
89	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99284467
90	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99284467
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99255008
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.98737397
93	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.97938080
94	NCOR_22424771_ChIP-Seq_293T_Human	0.97915911
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97655000
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97655000
97	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.94686755
98	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.94432395
99	EWS_26573619_Chip-Seq_HEK293_Human	0.93305193
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.92988683

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.48611072
2	MP0003136_yellow_coat_color	3.77324798
3	MP0000566_synostosis	3.74301154
4	MP0003122_maternal_imprinting	3.38570412
5	MP0009379_abnormal_foot_pigmentation	2.88036496
6	MP0008789_abnormal_olfactory_epithelium	2.78487900
7	MP0001986_abnormal_taste_sensitivity	2.51040793
8	MP0004885_abnormal_endolymph	2.43247060
9	MP0002638_abnormal_pupillary_reflex	2.41457823
10	MP0004142_abnormal_muscle_tone	2.38642204
11	MP0002653_abnormal_ependyma_morphology	2.25187662
12	MP0005394_taste/olfaction_phenotype	2.22490975
13	MP0005499_abnormal_olfactory_system	2.22490975
14	MP0005423_abnormal_somatic_nervous	2.20906395
15	MP0010030_abnormal_orbit_morphology	2.11164334
16	MP0005171_absent_coat_pigmentation	2.06527476
17	MP0002938_white_spotting	2.03957096
18	MP0001485_abnormal_pinna_reflex	2.03316907
19	MP0008877_abnormal_DNA_methylation	2.01532723
20	MP0004133_heterotaxia	1.92542400
21	MP0003938_abnormal_ear_development	1.82865859
22	MP0000631_abnormal_neuroendocrine_gland	1.82000549
23	MP0001293_anophthalmia	1.81889956
24	MP0003890_abnormal_embryonic-extraembry	1.77212706
25	MP0000778_abnormal_nervous_system	1.66850008
26	MP0002095_abnormal_skin_pigmentation	1.60257089
27	MP0005551_abnormal_eye_electrophysiolog	1.57627361
28	MP0008875_abnormal_xenobiotic_pharmacok	1.56327582
29	MP0002272_abnormal_nervous_system	1.56051132
30	MP0003646_muscle_fatigue	1.55107147
31	MP0002876_abnormal_thyroid_physiology	1.54946540
32	MP0003121_genomic_imprinting	1.50760456
33	MP0004859_abnormal_synaptic_plasticity	1.49590932
34	MP0003567_abnormal_fetal_cardiomyocyte	1.45396178
35	MP0003195_calcinosis	1.39386040
36	MP0006276_abnormal_autonomic_nervous	1.38201315
37	MP0000026_abnormal_inner_ear	1.37317861
38	MP0009745_abnormal_behavioral_response	1.36936252
39	MP0003787_abnormal_imprinting	1.36198568
40	MP0001968_abnormal_touch/_nociception	1.33867649
41	MP0005174_abnormal_tail_pigmentation	1.33158836
42	MP0003635_abnormal_synaptic_transmissio	1.29483819
43	MP0005084_abnormal_gallbladder_morpholo	1.27511071
44	MP0000372_irregular_coat_pigmentation	1.26381735
45	MP0002909_abnormal_adrenal_gland	1.26297742
46	MP0002572_abnormal_emotion/affect_behav	1.23021617
47	MP0008872_abnormal_physiological_respon	1.22521438
48	MP0001324_abnormal_eye_pigmentation	1.21093516
49	MP0000955_abnormal_spinal_cord	1.19198139
50	MP0009046_muscle_twitch	1.17895774
51	MP0005075_abnormal_melanosome_morpholog	1.16144342
52	MP0002928_abnormal_bile_duct	1.16030467
53	MP0000049_abnormal_middle_ear	1.13453126
54	MP0002063_abnormal_learning/memory/cond	1.10261634
55	MP0001970_abnormal_pain_threshold	1.07688862
56	MP0001963_abnormal_hearing_physiology	1.05837712
57	MP0006054_spinal_hemorrhage	1.04261662
58	MP0002752_abnormal_somatic_nervous	1.02727774
59	MP0001486_abnormal_startle_reflex	1.02645090
60	MP0002249_abnormal_larynx_morphology	1.00372775
61	MP0003880_abnormal_central_pattern	0.99485059
62	MP0006072_abnormal_retinal_apoptosis	0.97200105
63	MP0002064_seizures	0.96594255
64	MP0002837_dystrophic_cardiac_calcinosis	0.96420938
65	MP0002277_abnormal_respiratory_mucosa	0.96135105
66	MP0001905_abnormal_dopamine_level	0.94959068
67	MP0003937_abnormal_limbs/digits/tail_de	0.94195777
68	MP0002734_abnormal_mechanical_nocicepti	0.93916038
69	MP0000427_abnormal_hair_cycle	0.93741867
70	MP0002067_abnormal_sensory_capabilities	0.93582302
71	MP0004145_abnormal_muscle_electrophysio	0.93388515
72	MP0005195_abnormal_posterior_eye	0.92208114
73	MP0002282_abnormal_trachea_morphology	0.91403815
74	MP0001944_abnormal_pancreas_morphology	0.90714790
75	MP0001529_abnormal_vocalization	0.89212630
76	MP0002234_abnormal_pharynx_morphology	0.89114643
77	MP0002932_abnormal_joint_morphology	0.88752777
78	MP0004742_abnormal_vestibular_system	0.88444378
79	MP0002210_abnormal_sex_determination	0.88000305
80	MP0002736_abnormal_nociception_after	0.87886770
81	MP0002733_abnormal_thermal_nociception	0.87831510
82	MP0009384_cardiac_valve_regurgitation	0.86928261
83	MP0000428_abnormal_craniofacial_morphol	0.86228059
84	MP0002233_abnormal_nose_morphology	0.86140309
85	MP0001661_extended_life_span	0.81448714
86	MP0003011_delayed_dark_adaptation	0.79013433
87	MP0005248_abnormal_Harderian_gland	0.78170370
88	MP0002184_abnormal_innervation	0.76540841
89	MP0002882_abnormal_neuron_morphology	0.75579132
90	MP0002116_abnormal_craniofacial_bone	0.75354505
91	MP0002152_abnormal_brain_morphology	0.75271411
92	MP0003755_abnormal_palate_morphology	0.75267308
93	MP0002111_abnormal_tail_morphology	0.75083607
94	MP0000015_abnormal_ear_pigmentation	0.75057953
95	MP0003633_abnormal_nervous_system	0.73462160
96	MP0001984_abnormal_olfaction	0.72788020
97	MP0001286_abnormal_eye_development	0.72552802
98	MP0005367_renal/urinary_system_phenotyp	0.71769529
99	MP0000516_abnormal_urinary_system	0.71769529
100	MP0001440_abnormal_grooming_behavior	0.71690117

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	5.49035842
2	Nephronophthisis (HP:0000090)	5.40178377
3	Pancreatic fibrosis (HP:0100732)	5.36343839
4	Septo-optic dysplasia (HP:0100842)	4.56663543
5	Pancreatic cysts (HP:0001737)	4.40435667
6	Abnormality of the renal medulla (HP:0100957)	4.13942225
7	Molar tooth sign on MRI (HP:0002419)	4.13224128
8	Abnormality of midbrain morphology (HP:0002418)	4.13224128
9	True hermaphroditism (HP:0010459)	4.12819250
10	Tubular atrophy (HP:0000092)	3.93642616
11	Polydipsia (HP:0001959)	3.76899750
12	Abnormal drinking behavior (HP:0030082)	3.76899750
13	Abnormality of the renal cortex (HP:0011035)	3.65856407
14	Rib fusion (HP:0000902)	3.54994387
15	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.51228910
16	Abnormality of the aortic arch (HP:0012303)	3.48576002
17	Postaxial foot polydactyly (HP:0001830)	3.43003190
18	Hypoplasia of the capital femoral epiphysis (HP:0003090)	3.39966727
19	Sclerocornea (HP:0000647)	3.19636109
20	Medial flaring of the eyebrow (HP:0010747)	3.15349729
21	Congenital hepatic fibrosis (HP:0002612)	3.04082812
22	Chronic hepatic failure (HP:0100626)	2.97661879
23	Cystic liver disease (HP:0006706)	2.97080174
24	Maternal diabetes (HP:0009800)	2.95903032
25	Tubulointerstitial fibrosis (HP:0005576)	2.88815767
26	Absent septum pellucidum (HP:0001331)	2.82062678
27	Nephrogenic diabetes insipidus (HP:0009806)	2.80318599
28	Gait imbalance (HP:0002141)	2.79107726
29	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.76746557
30	Absent epiphyses (HP:0010577)	2.76746557
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.74841358
32	Amblyopia (HP:0000646)	2.74787897
33	Large for gestational age (HP:0001520)	2.72472732
34	Anencephaly (HP:0002323)	2.70053765
35	Optic nerve hypoplasia (HP:0000609)	2.67708336
36	Congenital primary aphakia (HP:0007707)	2.67175672
37	Postaxial hand polydactyly (HP:0001162)	2.63545507
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.57888999
39	Hepatocellular necrosis (HP:0001404)	2.57370733
40	Polyuria (HP:0000103)	2.53629514
41	Short femoral neck (HP:0100864)	2.45006633
42	Furrowed tongue (HP:0000221)	2.40480724
43	Occipital encephalocele (HP:0002085)	2.38923354
44	Vertebral clefting (HP:0008428)	2.34569300
45	Median cleft lip (HP:0000161)	2.32749138
46	Preaxial hand polydactyly (HP:0001177)	2.31436082
47	Stage 5 chronic kidney disease (HP:0003774)	2.29101362
48	Abnormality of the septum pellucidum (HP:0007375)	2.28994417
49	Congenital stationary night blindness (HP:0007642)	2.28475050
50	Renal dysplasia (HP:0000110)	2.26625931
51	Abnormality of cells of the erythroid lineage (HP:0012130)	2.26399524
52	Oligodactyly (hands) (HP:0001180)	2.24989006
53	Genital tract atresia (HP:0001827)	2.24622104
54	Hepatic necrosis (HP:0002605)	2.24284702
55	Mitochondrial inheritance (HP:0001427)	2.22303599
56	Oligodactyly (HP:0012165)	2.21604969
57	Hip dysplasia (HP:0001385)	2.18378102
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.17146817
59	Osteomalacia (HP:0002749)	2.16834945
60	Male pseudohermaphroditism (HP:0000037)	2.14046650
61	Lipid accumulation in hepatocytes (HP:0006561)	2.12259598
62	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.11901023
63	Poor coordination (HP:0002370)	2.11706958
64	Hypothermia (HP:0002045)	2.11180655
65	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.10765198
66	Abdominal situs inversus (HP:0003363)	2.09393368
67	Abnormality of abdominal situs (HP:0011620)	2.09393368
68	Polyphagia (HP:0002591)	2.08467342
69	Abnormality of the femoral head (HP:0003368)	2.07909048
70	Adrenal hypoplasia (HP:0000835)	2.07152269
71	Atonic seizures (HP:0010819)	2.06270411
72	Abnormal urine output (HP:0012590)	2.04486719
73	Abnormal number of erythroid precursors (HP:0012131)	2.04305978
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.04272962
75	Absent/shortened dynein arms (HP:0200106)	2.03775404
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03775404
77	Supernumerary bones of the axial skeleton (HP:0009144)	2.00416673
78	Increased CSF lactate (HP:0002490)	1.98338756
79	Increased hepatocellular lipid droplets (HP:0006565)	1.97903152
80	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.92868809
81	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.92868809
82	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.91755876
83	Abnormality of femoral epiphyses (HP:0006499)	1.91755876
84	Retinitis pigmentosa (HP:0000510)	1.91494945
85	Specific learning disability (HP:0001328)	1.91103637
86	Abnormality of the diencephalon (HP:0010662)	1.90904749
87	Vaginal atresia (HP:0000148)	1.87793800
88	Anophthalmia (HP:0000528)	1.80714890
89	Hyperventilation (HP:0002883)	1.80325088
90	Short tibia (HP:0005736)	1.79913679
91	Abnormality of renal excretion (HP:0011036)	1.79702864
92	Highly arched eyebrow (HP:0002553)	1.78890026
93	Tubulointerstitial abnormality (HP:0001969)	1.78620894
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78287045
95	Abnormality of alanine metabolism (HP:0010916)	1.78287045
96	Hyperalaninemia (HP:0003348)	1.78287045
97	Aplasia/hypoplasia of the femur (HP:0005613)	1.77616008
98	Gastrointestinal atresia (HP:0002589)	1.77411656
99	Intellectual disability, moderate (HP:0002342)	1.77252319
100	Multicystic kidney dysplasia (HP:0000003)	1.77099092

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	6.59305187
2	PNCK	4.27689120
3	MAP3K12	3.58707342
4	WNK3	2.76825767
5	TNIK	2.71828583
6	MAP4K2	2.29094912
7	NUAK1	2.14184246
8	MAP3K4	2.04397620
9	WNK4	2.03222555
10	DYRK2	2.02086879
11	MAP3K11	1.92948012
12	FRK	1.81245088
13	DAPK2	1.73642857
14	MAPK15	1.72499591
15	VRK2	1.71879583
16	STK16	1.62297632
17	ADRBK2	1.57462319
18	TAOK3	1.57259289
19	BCKDK	1.49716572
20	MARK1	1.45604204
21	TLK1	1.42335448
22	ZAK	1.41933911
23	INSRR	1.40557595
24	PAK3	1.39942247
25	WNK1	1.35387664
26	EPHB2	1.34979852
27	STK39	1.33010324
28	MAP2K4	1.31804679
29	STK11	1.30002527
30	NTRK2	1.23930274
31	PINK1	1.23880296
32	BMPR1B	1.22932417
33	MAPK13	1.21058464
34	MUSK	1.20645657
35	GRK1	1.14196044
36	EPHA4	1.05784258
37	PASK	1.01476984
38	NME1	1.01021799
39	CAMK1G	1.00488604
40	VRK1	0.97415908
41	ADRBK1	0.95880139
42	RPS6KB2	0.95591292
43	DYRK3	0.94388011
44	PLK4	0.93798863
45	OXSR1	0.92428184
46	BTK	0.91556832
47	TAF1	0.90346194
48	NTRK3	0.85298165
49	ITK	0.85250625
50	DYRK1A	0.79544697
51	CDC7	0.79162377
52	PLK2	0.76854206
53	PRKCG	0.74904338
54	NLK	0.73798615
55	TXK	0.72171910
56	TAOK2	0.69190390
57	CDK8	0.65238730
58	SGK494	0.64959912
59	SGK223	0.64959912
60	MAPKAPK5	0.64665265
61	MAP2K7	0.63076668
62	OBSCN	0.62271148
63	MAPKAPK3	0.61507531
64	CDK4	0.60205524
65	SIK2	0.59129405
66	PRKG1	0.55333037
67	GRK7	0.55312850
68	CDK19	0.51871743
69	STK24	0.51031318
70	PHKG2	0.50565143
71	PHKG1	0.50565143
72	ABL2	0.50339277
73	PTK6	0.50205924
74	WEE1	0.49920300
75	PIK3CA	0.49893074
76	FGFR1	0.49592586
77	CSNK1E	0.49394589
78	DAPK3	0.48380270
79	HIPK2	0.47692725
80	STK38L	0.46152801
81	PRKCE	0.45610849
82	PRKACA	0.44021422
83	SGK1	0.43798021
84	PRKCQ	0.43311511
85	PRKACB	0.42906949
86	PKN1	0.42775995
87	CSNK2A2	0.42313157
88	CAMK1D	0.40721733
89	TIE1	0.40575708
90	CSNK1A1	0.38438865
91	MAP3K7	0.35729931
92	PRKCZ	0.35721143
93	MAP2K6	0.35192723
94	STK3	0.34969248
95	ROCK1	0.34628343
96	PRKCI	0.34176053
97	NEK2	0.34122302
98	MATK	0.34012048
99	AKT1	0.32232430
100	IRAK4	0.32192785

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.01774143
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.90085286
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.34416339
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.65457288
5	Parkinsons disease_Homo sapiens_hsa05012	2.61165164
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.38604622
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29283965
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.28675276
9	Protein export_Homo sapiens_hsa03060	2.23986626
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.19147688
11	Huntingtons disease_Homo sapiens_hsa05016	2.12200932
12	Nicotine addiction_Homo sapiens_hsa05033	2.10708159
13	RNA polymerase_Homo sapiens_hsa03020	1.88169078
14	Homologous recombination_Homo sapiens_hsa03440	1.87869409
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.82038048
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.75610099
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.71338061
18	Butanoate metabolism_Homo sapiens_hsa00650	1.67847234
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.65887095
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65114542
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64745304
22	Lysine degradation_Homo sapiens_hsa00310	1.59980161
23	Alzheimers disease_Homo sapiens_hsa05010	1.56906860
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.56284768
25	Folate biosynthesis_Homo sapiens_hsa00790	1.51971842
26	Peroxisome_Homo sapiens_hsa04146	1.50564076
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.50264670
28	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.45310459
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.43579279
30	Insulin secretion_Homo sapiens_hsa04911	1.42677618
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34004837
32	Basal transcription factors_Homo sapiens_hsa03022	1.30754097
33	RNA degradation_Homo sapiens_hsa03018	1.29613308
34	Sulfur metabolism_Homo sapiens_hsa00920	1.27432214
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.26030346
36	Caffeine metabolism_Homo sapiens_hsa00232	1.25731423
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.25640592
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21871676
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.20955354
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18798726
41	Type II diabetes mellitus_Homo sapiens_hsa04930	1.16236772
42	Fatty acid degradation_Homo sapiens_hsa00071	1.14695612
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09082941
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03387468
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02980870
46	Notch signaling pathway_Homo sapiens_hsa04330	1.01742485
47	Propanoate metabolism_Homo sapiens_hsa00640	1.00704334
48	Retinol metabolism_Homo sapiens_hsa00830	1.00521172
49	Phototransduction_Homo sapiens_hsa04744	0.98620513
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94936417
51	Taste transduction_Homo sapiens_hsa04742	0.94017229
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92331936
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.91455690
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87695429
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.82035486
56	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.80119369
57	Fatty acid elongation_Homo sapiens_hsa00062	0.78716164
58	Metabolic pathways_Homo sapiens_hsa01100	0.74312327
59	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.72270441
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71834435
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71233035
62	Purine metabolism_Homo sapiens_hsa00230	0.70568158
63	Morphine addiction_Homo sapiens_hsa05032	0.69670816
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67569262
65	GABAergic synapse_Homo sapiens_hsa04727	0.67568684
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67143310
67	Glutathione metabolism_Homo sapiens_hsa00480	0.66089091
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66019714
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64785646
70	Mismatch repair_Homo sapiens_hsa03430	0.63403082
71	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.61695736
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.58097567
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56288964
74	Olfactory transduction_Homo sapiens_hsa04740	0.54971243
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53502830
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.52285261
77	Histidine metabolism_Homo sapiens_hsa00340	0.51824366
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49428628
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46115065
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45212219
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.44896636
82	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.44525200
83	Mineral absorption_Homo sapiens_hsa04978	0.42126886
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41192598
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39922762
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38332154
87	ABC transporters_Homo sapiens_hsa02010	0.36024330
88	Axon guidance_Homo sapiens_hsa04360	0.35904684
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.35254944
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34294056
91	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.33723882
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.33439769
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33090112
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.32569951
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.32385643
96	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31202521
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27926610
98	Cocaine addiction_Homo sapiens_hsa05030	0.27233671
99	Serotonergic synapse_Homo sapiens_hsa04726	0.27165790
100	Salivary secretion_Homo sapiens_hsa04970	0.27118088

RPL12P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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