ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleoside salvage (GO:0043097)	9.15934846
2	pyrimidine-containing compound salvage (GO:0008655)	9.15934846
3	nucleotide salvage (GO:0043173)	8.96371722
4	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	8.47944375
5	UMP biosynthetic process (GO:0006222)	8.47944375
6	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	8.47944375
7	UMP metabolic process (GO:0046049)	8.47944375
8	nucleoside salvage (GO:0043174)	8.46756388
9	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	7.40244332
10	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	6.89492838
11	keratinocyte development (GO:0003334)	6.52339355
12	pentose metabolic process (GO:0019321)	5.28553280
13	CTP biosynthetic process (GO:0006241)	5.15570634
14	CTP metabolic process (GO:0046036)	5.15570634
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.95894445
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.95894445
17	diterpenoid biosynthetic process (GO:0016102)	4.82740290
18	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.55797005
19	protein polyglutamylation (GO:0018095)	4.52179471
20	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	4.28241054
21	response to folic acid (GO:0051593)	4.21230951
22	purine nucleotide salvage (GO:0032261)	4.19928534
23	response to pheromone (GO:0019236)	4.14043863
24	cellular metabolic compound salvage (GO:0043094)	4.10216344
25	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.00263483
26	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.87996593
27	translational termination (GO:0006415)	3.85465574
28	viral transcription (GO:0019083)	3.83318804
29	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.76491333
30	acrosome reaction (GO:0007340)	3.72186619
31	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.68209649
32	terpenoid biosynthetic process (GO:0016114)	3.67940658
33	translational elongation (GO:0006414)	3.60742720
34	tRNA modification (GO:0006400)	3.55167564
35	ribosomal small subunit assembly (GO:0000028)	3.53253525
36	regulation of activation of Janus kinase activity (GO:0010533)	3.47472744
37	DNA ligation (GO:0006266)	3.44411361
38	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.43321446
39	negative regulation of keratinocyte proliferation (GO:0010839)	3.41126028
40	negative regulation of JAK-STAT cascade (GO:0046426)	3.40054841
41	transcription from mitochondrial promoter (GO:0006390)	3.36091128
42	interleukin-6-mediated signaling pathway (GO:0070102)	3.34995823
43	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.34287502
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24498681
45	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.22545110
46	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21643026
47	activation of NF-kappaB-inducing kinase activity (GO:0007250)	3.15881633
48	cellular ketone body metabolic process (GO:0046950)	3.15194928
49	amino acid salvage (GO:0043102)	3.11707326
50	L-methionine salvage (GO:0071267)	3.11707326
51	L-methionine biosynthetic process (GO:0071265)	3.11707326
52	cellular protein complex disassembly (GO:0043624)	3.00322102
53	protein complex biogenesis (GO:0070271)	2.99353206
54	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.99301431
55	regulation of cilium movement (GO:0003352)	2.98199220
56	fusion of sperm to egg plasma membrane (GO:0007342)	2.98011268
57	positive regulation of humoral immune response (GO:0002922)	2.96010852
58	pentose-phosphate shunt (GO:0006098)	2.93398489
59	sperm motility (GO:0030317)	2.91552117
60	cotranslational protein targeting to membrane (GO:0006613)	2.91322416
61	ketone body metabolic process (GO:1902224)	2.86459722
62	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.86322572
63	protein targeting to ER (GO:0045047)	2.84687720
64	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.83984762
65	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.82944657
66	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.82944657
67	grooming behavior (GO:0007625)	2.81410368
68	pyrimidine nucleoside biosynthetic process (GO:0046134)	2.79370508
69	NADPH regeneration (GO:0006740)	2.75831990
70	tRNA processing (GO:0008033)	2.74394055
71	spermatid development (GO:0007286)	2.73900033
72	regulation of regulatory T cell differentiation (GO:0045589)	2.70032105
73	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.69845467
74	seminiferous tubule development (GO:0072520)	2.69007205
75	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.68181928
76	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.65896339
77	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.65896339
78	peptidyl-cysteine modification (GO:0018198)	2.65584314
79	protein localization to endoplasmic reticulum (GO:0070972)	2.65298215
80	RNA destabilization (GO:0050779)	2.64986297
81	heparin biosynthetic process (GO:0030210)	2.62836028
82	heparin metabolic process (GO:0030202)	2.62836028
83	L-fucose catabolic process (GO:0042355)	2.62274249
84	fucose catabolic process (GO:0019317)	2.62274249
85	L-fucose metabolic process (GO:0042354)	2.62274249
86	positive regulation of endothelial cell differentiation (GO:0045603)	2.60077969
87	centrosome duplication (GO:0051298)	2.58866614
88	axonemal dynein complex assembly (GO:0070286)	2.58814570
89	catecholamine transport (GO:0051937)	2.57298229
90	neutrophil mediated immunity (GO:0002446)	2.56642198
91	pyrimidine-containing compound biosynthetic process (GO:0072528)	2.56379734
92	cytochrome complex assembly (GO:0017004)	2.55158433
93	glycerol metabolic process (GO:0006071)	2.54699118
94	DNA deamination (GO:0045006)	2.52649621
95	regulation of T cell receptor signaling pathway (GO:0050856)	2.50963187
96	behavioral response to nicotine (GO:0035095)	2.50931172
97	indolalkylamine metabolic process (GO:0006586)	2.50920260
98	viral life cycle (GO:0019058)	2.50884148
99	single strand break repair (GO:0000012)	2.49919168
100	purine nucleobase biosynthetic process (GO:0009113)	2.49823553

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.16173763
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.35254070
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.31503662
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19933591
5	VDR_22108803_ChIP-Seq_LS180_Human	2.39727005
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.38361681
7	RUNX_20019798_ChIP-Seq_JUKART_Human	2.35876480
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.32878304
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31977924
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.19478499
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17551387
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.06378164
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03620655
14	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.95553813
15	FUS_26573619_Chip-Seq_HEK293_Human	1.91217331
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89622771
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89386012
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88207924
19	P300_19829295_ChIP-Seq_ESCs_Human	1.85169321
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.75259151
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.75150547
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70315960
23	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.69990295
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69822585
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.69121863
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69121863
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66678160
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.61042306
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61021164
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.58712534
31	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.57656245
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.56384170
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.52623350
34	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.52542026
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48875084
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.47269019
37	GATA3_26560356_Chip-Seq_TH2_Human	1.45870233
38	NCOR_22424771_ChIP-Seq_293T_Human	1.41667960
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41557663
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.38316533
41	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.36934962
42	ERA_21632823_ChIP-Seq_H3396_Human	1.29540388
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26985611
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25435577
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24976324
46	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.24778780
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21787030
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21647560
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21647560
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21503657
51	MYC_19829295_ChIP-Seq_ESCs_Human	1.20963681
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18783646
53	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.18551380
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18395075
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17316336
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17316336
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15068549
58	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.14302592
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13882376
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11835498
61	EWS_26573619_Chip-Seq_HEK293_Human	1.11120972
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10948517
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10597400
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10262923
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09988462
66	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.09322682
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08686390
68	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.08545330
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08530408
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08159748
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07898948
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.07859229
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07136550
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.07036733
75	TCF4_23295773_ChIP-Seq_U87_Human	1.06750928
76	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.06398542
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05187176
78	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03246364
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02797252
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02530553
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02222446
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01418366
83	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01304518
84	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01010022
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99902411
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99387075
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99289815
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.99282426
89	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98496307
90	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97952523
91	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97795391
92	AR_20517297_ChIP-Seq_VCAP_Human	0.97301496
93	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.97148929
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.96868563
95	AR_25329375_ChIP-Seq_VCAP_Human	0.96078576
96	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95532105
97	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95258272
98	JUN_21703547_ChIP-Seq_K562_Human	0.94940399
99	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.94706223
100	GATA3_26560356_Chip-Seq_TH1_Human	0.93445896

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.26348916
2	MP0005646_abnormal_pituitary_gland	3.15523241
3	MP0006292_abnormal_olfactory_placode	2.99717082
4	MP0002163_abnormal_gland_morphology	2.74442780
5	MP0005410_abnormal_fertilization	2.62372054
6	MP0005645_abnormal_hypothalamus_physiol	2.61453144
7	MP0003880_abnormal_central_pattern	2.59497718
8	MP0005671_abnormal_response_to	2.48522728
9	MP0008875_abnormal_xenobiotic_pharmacok	2.48305654
10	MP0005379_endocrine/exocrine_gland_phen	2.32704135
11	MP0003878_abnormal_ear_physiology	2.15435637
12	MP0005377_hearing/vestibular/ear_phenot	2.15435637
13	MP0002102_abnormal_ear_morphology	2.13312096
14	MP0000372_irregular_coat_pigmentation	2.08225137
15	MP0008872_abnormal_physiological_respon	1.97659967
16	MP0001348_abnormal_lacrimal_gland	1.95730921
17	MP0003724_increased_susceptibility_to	1.85288563
18	MP0002736_abnormal_nociception_after	1.84142302
19	MP0002837_dystrophic_cardiac_calcinosis	1.82948918
20	MP0001968_abnormal_touch/_nociception	1.80788079
21	MP0005075_abnormal_melanosome_morpholog	1.80598293
22	MP0003136_yellow_coat_color	1.77839898
23	MP0004381_abnormal_hair_follicle	1.77146048
24	MP0005551_abnormal_eye_electrophysiolog	1.73882210
25	MP0000383_abnormal_hair_follicle	1.67663562
26	MP0002234_abnormal_pharynx_morphology	1.61082051
27	MP0005253_abnormal_eye_physiology	1.54430857
28	MP0003943_abnormal_hepatobiliary_system	1.48150731
29	MP0002095_abnormal_skin_pigmentation	1.44578442
30	MP0006072_abnormal_retinal_apoptosis	1.37523205
31	MP0005360_urolithiasis	1.35302653
32	MP0001984_abnormal_olfaction	1.31287731
33	MP0006276_abnormal_autonomic_nervous	1.31244227
34	MP0005000_abnormal_immune_tolerance	1.27599209
35	MP0008877_abnormal_DNA_methylation	1.22722659
36	MP0009745_abnormal_behavioral_response	1.22515874
37	MP0001529_abnormal_vocalization	1.19803820
38	MP0001486_abnormal_startle_reflex	1.19164230
39	MP0009785_altered_susceptibility_to	1.17500174
40	MP0003195_calcinosis	1.16252214
41	MP0009379_abnormal_foot_pigmentation	1.15902787
42	MP0001986_abnormal_taste_sensitivity	1.15437476
43	MP0001905_abnormal_dopamine_level	1.15056620
44	MP0003698_abnormal_male_reproductive	1.13766151
45	MP0001873_stomach_inflammation	1.12499169
46	MP0001346_abnormal_lacrimal_gland	1.10622587
47	MP0005310_abnormal_salivary_gland	1.10098573
48	MP0000538_abnormal_urinary_bladder	1.09945673
49	MP0008789_abnormal_olfactory_epithelium	1.08032608
50	MP0001501_abnormal_sleep_pattern	1.07727748
51	MP0005167_abnormal_blood-brain_barrier	1.07190347
52	MP0003011_delayed_dark_adaptation	1.07052259
53	MP0001800_abnormal_humoral_immune	1.05611605
54	MP0002638_abnormal_pupillary_reflex	1.04057558
55	MP0004043_abnormal_pH_regulation	1.03629920
56	MP0003763_abnormal_thymus_physiology	1.03357329
57	MP0002733_abnormal_thermal_nociception	1.02690603
58	MP0003693_abnormal_embryo_hatching	0.98944741
59	MP0002723_abnormal_immune_serum	0.98223100
60	MP0004142_abnormal_muscle_tone	0.97499651
61	MP0006082_CNS_inflammation	0.97360151
62	MP0010329_abnormal_lipoprotein_level	0.95817664
63	MP0001293_anophthalmia	0.95764133
64	MP0001919_abnormal_reproductive_system	0.95708197
65	MP0001929_abnormal_gametogenesis	0.94660937
66	MP0005389_reproductive_system_phenotype	0.93424917
67	MP0005332_abnormal_amino_acid	0.92055371
68	MP0005174_abnormal_tail_pigmentation	0.91381194
69	MP0000631_abnormal_neuroendocrine_gland	0.90366371
70	MP0000015_abnormal_ear_pigmentation	0.90217267
71	MP0002735_abnormal_chemical_nociception	0.90196904
72	MP0001765_abnormal_ion_homeostasis	0.89838329
73	MP0001819_abnormal_immune_cell	0.89347262
74	MP0002876_abnormal_thyroid_physiology	0.88820381
75	MP0001485_abnormal_pinna_reflex	0.87756354
76	MP0005085_abnormal_gallbladder_physiolo	0.87341885
77	MP0005423_abnormal_somatic_nervous	0.86946141
78	MP0001970_abnormal_pain_threshold	0.86806775
79	MP0010155_abnormal_intestine_physiology	0.86800763
80	MP0002822_catalepsy	0.86661073
81	MP0002420_abnormal_adaptive_immunity	0.85696061
82	MP0000427_abnormal_hair_cycle	0.84110044
83	MP0002452_abnormal_antigen_presenting	0.84056466
84	MP0000647_abnormal_sebaceous_gland	0.82089521
85	MP0002751_abnormal_autonomic_nervous	0.81962677
86	MP0002272_abnormal_nervous_system	0.81483635
87	MP0002938_white_spotting	0.80400342
88	MP0003718_maternal_effect	0.79307622
89	MP0002933_joint_inflammation	0.78958060
90	MP0008775_abnormal_heart_ventricle	0.78184392
91	MP0001944_abnormal_pancreas_morphology	0.77748751
92	MP0001879_abnormal_lymphatic_vessel	0.76657349
93	MP0002127_abnormal_cardiovascular_syste	0.75063166
94	MP0000703_abnormal_thymus_morphology	0.74377007
95	MP0005391_vision/eye_phenotype	0.73670136
96	MP0010386_abnormal_urinary_bladder	0.73534156
97	MP0004147_increased_porphyrin_level	0.73475744
98	MP0008873_increased_physiological_sensi	0.72662531
99	MP0001845_abnormal_inflammatory_respons	0.70373003
100	MP0005365_abnormal_bile_salt	0.70183290

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hip dysplasia (HP:0001385)	4.55809324
2	Hyperglycinemia (HP:0002154)	3.70597066
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.66863750
4	Absent/shortened dynein arms (HP:0200106)	3.66863750
5	Pancreatic fibrosis (HP:0100732)	3.64360706
6	Hypoplasia of the pons (HP:0012110)	3.51994564
7	Abnormality of the pons (HP:0007361)	3.37414379
8	Pancreatic cysts (HP:0001737)	3.23778813
9	Progressive microcephaly (HP:0000253)	3.23521759
10	Poor suck (HP:0002033)	3.04038937
11	IgG deficiency (HP:0004315)	3.03765625
12	Hip contracture (HP:0003273)	3.02904088
13	Tubulointerstitial nephritis (HP:0001970)	3.01872669
14	Congenital stationary night blindness (HP:0007642)	2.93708839
15	Methylmalonic acidemia (HP:0002912)	2.90811261
16	Difficulty running (HP:0009046)	2.86948680
17	Acute necrotizing encephalopathy (HP:0006965)	2.83483233
18	Abnormal number of erythroid precursors (HP:0012131)	2.77922858
19	Opisthotonus (HP:0002179)	2.65552598
20	Chronic hepatic failure (HP:0100626)	2.64694758
21	True hermaphroditism (HP:0010459)	2.62537539
22	Parakeratosis (HP:0001036)	2.61275817
23	Abnormality of midbrain morphology (HP:0002418)	2.61244427
24	Molar tooth sign on MRI (HP:0002419)	2.61244427
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.56085273
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.56085273
27	Progressive macrocephaly (HP:0004481)	2.55344111
28	Abnormality of the renal cortex (HP:0011035)	2.54769804
29	Methylmalonic aciduria (HP:0012120)	2.50643606
30	Dyskinesia (HP:0100660)	2.48817061
31	Abnormal ciliary motility (HP:0012262)	2.46518944
32	Elevated erythrocyte sedimentation rate (HP:0003565)	2.45423750
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.44513022
34	Limited hip movement (HP:0008800)	2.44125084
35	Acute encephalopathy (HP:0006846)	2.43919430
36	Sclerocornea (HP:0000647)	2.42898179
37	Mitochondrial inheritance (HP:0001427)	2.39373030
38	Impaired smooth pursuit (HP:0007772)	2.38148526
39	Polydipsia (HP:0001959)	2.37704423
40	Abnormal drinking behavior (HP:0030082)	2.37704423
41	B lymphocytopenia (HP:0010976)	2.37120671
42	Renal Fanconi syndrome (HP:0001994)	2.35268310
43	Renal cortical cysts (HP:0000803)	2.34852614
44	Nephrogenic diabetes insipidus (HP:0009806)	2.33328724
45	Abnormality of cells of the erythroid lineage (HP:0012130)	2.28249934
46	Attenuation of retinal blood vessels (HP:0007843)	2.27846953
47	Medial flaring of the eyebrow (HP:0010747)	2.25262979
48	Abnormality of macular pigmentation (HP:0008002)	2.21633667
49	Abnormality of the renal medulla (HP:0100957)	2.20246816
50	Abnormal respiratory motile cilium physiology (HP:0012261)	2.19588113
51	Poor speech (HP:0002465)	2.16300793
52	Abnormality of B cell number (HP:0010975)	2.15953469
53	Increased hepatocellular lipid droplets (HP:0006565)	2.13239340
54	Nephronophthisis (HP:0000090)	2.10124266
55	Thyroiditis (HP:0100646)	2.09941598
56	IgM deficiency (HP:0002850)	2.09671802
57	Increased CSF lactate (HP:0002490)	2.08951512
58	Cystic liver disease (HP:0006706)	2.08551575
59	Short femoral neck (HP:0100864)	2.07915813
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.07367281
61	Hyperthyroidism (HP:0000836)	2.02803564
62	Congenital primary aphakia (HP:0007707)	2.02363043
63	Restlessness (HP:0000711)	2.02035708
64	Gait imbalance (HP:0002141)	2.01541604
65	Abnormality of the periventricular white matter (HP:0002518)	2.01537473
66	Abnormality of chromosome stability (HP:0003220)	2.01095233
67	Polyuria (HP:0000103)	1.98592119
68	Abnormality of T cell physiology (HP:0011840)	1.98200008
69	Severe combined immunodeficiency (HP:0004430)	1.94289776
70	Achilles tendon contracture (HP:0001771)	1.92610520
71	Occipital encephalocele (HP:0002085)	1.92176813
72	Postaxial foot polydactyly (HP:0001830)	1.91809217
73	Delayed CNS myelination (HP:0002188)	1.91652312
74	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.91375947
75	Hypoplasia of the brainstem (HP:0002365)	1.91375947
76	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91140489
77	Hypomagnesemia (HP:0002917)	1.87315937
78	Cerebral edema (HP:0002181)	1.86486010
79	Lipid accumulation in hepatocytes (HP:0006561)	1.84504759
80	Sacral dimple (HP:0000960)	1.83476232
81	Short tibia (HP:0005736)	1.82922072
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.81996805
83	Abnormality of T cells (HP:0002843)	1.81596578
84	Abnormality of the 4th metacarpal (HP:0010012)	1.80680509
85	Tubulointerstitial abnormality (HP:0001969)	1.80180104
86	3-Methylglutaconic aciduria (HP:0003535)	1.78676977
87	Cerebral hypomyelination (HP:0006808)	1.78019069
88	T lymphocytopenia (HP:0005403)	1.77867792
89	Chorioretinal atrophy (HP:0000533)	1.75802036
90	Female pseudohermaphroditism (HP:0010458)	1.75257790
91	Genetic anticipation (HP:0003743)	1.74549642
92	Absent thumb (HP:0009777)	1.74323431
93	Type II lissencephaly (HP:0007260)	1.73209425
94	Abnormal urine output (HP:0012590)	1.72205307
95	Lissencephaly (HP:0001339)	1.71170719
96	Abnormality of the Achilles tendon (HP:0005109)	1.68986190
97	Hyperphosphaturia (HP:0003109)	1.67627808
98	Renal dysplasia (HP:0000110)	1.66842006
99	Optic disc pallor (HP:0000543)	1.66773514
100	Severe visual impairment (HP:0001141)	1.65829625

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.83590504
2	TXK	4.20021334
3	LIMK1	3.67292280
4	TRIM28	3.38420063
5	FRK	2.92151327
6	EPHA4	2.79728070
7	BCKDK	2.77204357
8	MAP4K1	2.46114804
9	TESK1	2.37854780
10	NLK	2.35646139
11	PLK4	2.01010341
12	ADRBK2	1.95414217
13	INSRR	1.91998631
14	TNK2	1.70963520
15	PINK1	1.69360879
16	WNK3	1.53944246
17	BMPR1B	1.36951052
18	GRK1	1.32931932
19	TEC	1.32760725
20	PLK2	1.30862541
21	TLK1	1.22170606
22	ITK	1.22046517
23	NUAK1	1.15429717
24	PDK2	1.13400149
25	GRK6	1.09917637
26	ACVR1B	1.02808307
27	WNK4	1.01790460
28	CDK19	1.01440695
29	PTK2B	1.01116444
30	BTK	0.99672265
31	BUB1	0.98294762
32	PASK	0.95086121
33	PRKCQ	0.93295381
34	MAP2K7	0.92419997
35	ERBB3	0.92106932
36	TIE1	0.90744256
37	MUSK	0.89701577
38	KDR	0.88280070
39	MAP3K4	0.87818485
40	SYK	0.85179642
41	CSNK1G1	0.85022586
42	PRKCG	0.83203316
43	IKBKB	0.82907574
44	LCK	0.82650944
45	ADRBK1	0.80609860
46	LYN	0.80284882
47	MAP2K2	0.78844810
48	CSF1R	0.78473323
49	ZAK	0.78089921
50	MAPK15	0.77559435
51	MAPK13	0.74598300
52	DYRK2	0.74338985
53	EPHA3	0.71426072
54	TAOK3	0.68688813
55	RPS6KA5	0.66868685
56	CAMKK2	0.66127911
57	PIK3CA	0.61677714
58	MINK1	0.60037378
59	OBSCN	0.55346666
60	CSNK1A1	0.55091418
61	OXSR1	0.51669352
62	PDK1	0.49720201
63	PKN1	0.48249558
64	GRK7	0.48239674
65	IGF1R	0.48105703
66	CDK4	0.47234492
67	PRKCA	0.46710865
68	NME1	0.45447278
69	PAK6	0.43181619
70	PAK3	0.42843621
71	MARK1	0.41826567
72	MAP3K13	0.41735025
73	DYRK1A	0.41245330
74	CSNK2A2	0.39469509
75	GRK5	0.37646779
76	BMPR2	0.37588543
77	IKBKE	0.37353306
78	PRKCE	0.35977516
79	DYRK3	0.35295064
80	TNIK	0.34918426
81	ABL1	0.34737548
82	BCR	0.34174704
83	LRRK2	0.34085403
84	PIK3CG	0.33831614
85	SGK2	0.33087406
86	ROCK1	0.31434590
87	CDC42BPA	0.31279015
88	PRKACA	0.30956059
89	PLK1	0.30267937
90	TGFBR1	0.30169890
91	STK16	0.30015018
92	CAMK2A	0.29187620
93	TBK1	0.27802792
94	STK38L	0.27648374
95	CSNK2A1	0.27532887
96	CAMK1	0.27465340
97	PRKG1	0.26969090
98	SGK223	0.26595878
99	SGK494	0.26595878
100	BRD4	0.26192783

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	5.43836407
2	Ribosome_Homo sapiens_hsa03010	4.09447093
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.15648835
4	RNA polymerase_Homo sapiens_hsa03020	2.71510825
5	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.59560797
6	Butanoate metabolism_Homo sapiens_hsa00650	2.42765972
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.38844969
8	Phototransduction_Homo sapiens_hsa04744	2.21618270
9	Pyrimidine metabolism_Homo sapiens_hsa00240	2.15317244
10	Sulfur metabolism_Homo sapiens_hsa00920	2.14367821
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95439926
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87530728
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79739122
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67663980
15	Fat digestion and absorption_Homo sapiens_hsa04975	1.60985178
16	Propanoate metabolism_Homo sapiens_hsa00640	1.54977709
17	Parkinsons disease_Homo sapiens_hsa05012	1.51772831
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.50106747
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48781633
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.47427113
21	Caffeine metabolism_Homo sapiens_hsa00232	1.43181012
22	Taste transduction_Homo sapiens_hsa04742	1.42956979
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42825795
24	Glycerolipid metabolism_Homo sapiens_hsa00561	1.41349428
25	Nicotine addiction_Homo sapiens_hsa05033	1.40309157
26	Pentose phosphate pathway_Homo sapiens_hsa00030	1.39398524
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.36336356
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35820895
29	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.31713412
30	Huntingtons disease_Homo sapiens_hsa05016	1.28754836
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.27648526
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25551153
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23133568
34	Purine metabolism_Homo sapiens_hsa00230	1.22987948
35	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.21681544
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.20247721
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.17066747
38	Olfactory transduction_Homo sapiens_hsa04740	1.16294700
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12589860
40	Graft-versus-host disease_Homo sapiens_hsa05332	1.12039311
41	RNA degradation_Homo sapiens_hsa03018	1.11372799
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.08018390
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05797787
44	Peroxisome_Homo sapiens_hsa04146	1.02920005
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02208136
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01532592
47	Alzheimers disease_Homo sapiens_hsa05010	0.98250099
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92539267
49	Allograft rejection_Homo sapiens_hsa05330	0.91791119
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91381242
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.90859312
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.84718052
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.84308286
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.83404710
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82820925
56	Retinol metabolism_Homo sapiens_hsa00830	0.82414693
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82056456
58	Measles_Homo sapiens_hsa05162	0.81358892
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80884900
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77759700
61	Homologous recombination_Homo sapiens_hsa03440	0.77589717
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77202984
63	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.72186565
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72023492
65	Metabolic pathways_Homo sapiens_hsa01100	0.71966967
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69990010
67	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69004164
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67250977
69	Salivary secretion_Homo sapiens_hsa04970	0.66386669
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65745065
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63687417
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63160452
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62942911
74	Morphine addiction_Homo sapiens_hsa05032	0.61746215
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59310261
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.57021182
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55223742
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54229624
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.52439103
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50640430
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45927643
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45571555
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.44033149
84	Basal transcription factors_Homo sapiens_hsa03022	0.44014381
85	Folate biosynthesis_Homo sapiens_hsa00790	0.42876242
86	RNA transport_Homo sapiens_hsa03013	0.39279566
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38357020
88	Regulation of autophagy_Homo sapiens_hsa04140	0.38209187
89	ABC transporters_Homo sapiens_hsa02010	0.37379634
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37075820
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.36937248
92	Antigen processing and presentation_Homo sapiens_hsa04612	0.36649100
93	Fatty acid degradation_Homo sapiens_hsa00071	0.34647411
94	Serotonergic synapse_Homo sapiens_hsa04726	0.34487417
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.32079007
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.31361459
97	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.28337223
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27453863
99	Insulin secretion_Homo sapiens_hsa04911	0.27314784
100	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.24967990

RPL12P29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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