ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	purine deoxyribonucleotide metabolic process (GO:0009151)	4.77529512
2	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.75762556
3	regulation of memory T cell differentiation (GO:0043380)	4.67239336
4	mitochondrial calcium ion transport (GO:0006851)	4.60619973
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.59808738
6	ATP synthesis coupled proton transport (GO:0015986)	4.48028117
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.48028117
8	regulation of activation of Janus kinase activity (GO:0010533)	4.46550129
9	ribosomal small subunit assembly (GO:0000028)	4.40345949
10	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.35271774
11	purine deoxyribonucleotide catabolic process (GO:0009155)	4.31003832
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.03581819
13	ADP metabolic process (GO:0046031)	4.01842704
14	interferon-gamma production (GO:0032609)	4.01124695
15	respiratory electron transport chain (GO:0022904)	4.00508450
16	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	4.00294726
17	chaperone-mediated protein transport (GO:0072321)	3.99807206
18	base-excision repair, AP site formation (GO:0006285)	3.98996689
19	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.97661893
20	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.96964315
21	electron transport chain (GO:0022900)	3.96297323
22	protein-cofactor linkage (GO:0018065)	3.82067724
23	positive regulation of osteoclast differentiation (GO:0045672)	3.71873347
24	cellular ketone body metabolic process (GO:0046950)	3.70426261
25	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.64356598
26	negative regulation of mast cell activation (GO:0033004)	3.58978769
27	mast cell activation (GO:0045576)	3.47831493
28	viral transcription (GO:0019083)	3.47606309
29	positive regulation of T-helper 1 type immune response (GO:0002827)	3.47497889
30	translational termination (GO:0006415)	3.46500723
31	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.46479733
32	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.33706076
33	positive regulation of interleukin-17 production (GO:0032740)	3.32231874
34	ketone body metabolic process (GO:1902224)	3.30224750
35	2-deoxyribonucleotide metabolic process (GO:0009394)	3.28775312
36	cellular response to interleukin-15 (GO:0071350)	3.25937428
37	ATP biosynthetic process (GO:0006754)	3.23353240
38	positive regulation of defense response to virus by host (GO:0002230)	3.23065780
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22437939
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22437939
41	NADH dehydrogenase complex assembly (GO:0010257)	3.22437939
42	positive regulation of cell fate commitment (GO:0010455)	3.19163345
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.18240790
44	protein complex biogenesis (GO:0070271)	3.17907846
45	mast cell degranulation (GO:0043303)	3.17371460
46	mast cell activation involved in immune response (GO:0002279)	3.17371460
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.11954630
48	DNA deamination (GO:0045006)	3.07148287
49	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.05476451
50	hydrogen ion transmembrane transport (GO:1902600)	3.03890273
51	translational elongation (GO:0006414)	3.03859916
52	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	3.02262222
53	cotranslational protein targeting to membrane (GO:0006613)	2.97871050
54	regulation of T cell mediated cytotoxicity (GO:0001914)	2.97445854
55	DNA dealkylation (GO:0035510)	2.95940540
56	deoxyribose phosphate metabolic process (GO:0019692)	2.95566949
57	molting cycle (GO:0042303)	2.94140425
58	hair cycle (GO:0042633)	2.94140425
59	mitochondrial calcium ion homeostasis (GO:0051560)	2.94099110
60	adenosine metabolic process (GO:0046085)	2.92886436
61	protein targeting to ER (GO:0045047)	2.91106002
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.90930231
63	peptidyl-histidine modification (GO:0018202)	2.89594728
64	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.89127502
65	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.89045446
66	proton transport (GO:0015992)	2.88614413
67	deoxyribonucleotide catabolic process (GO:0009264)	2.86191671
68	regulation of cilium movement (GO:0003352)	2.85738494
69	regulation of interleukin-8 secretion (GO:2000482)	2.85491070
70	tachykinin receptor signaling pathway (GO:0007217)	2.84761978
71	protein localization to endoplasmic reticulum (GO:0070972)	2.83683502
72	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83575059
73	negative regulation of interleukin-10 production (GO:0032693)	2.82867521
74	hydrogen transport (GO:0006818)	2.82381000
75	mannosylation (GO:0097502)	2.81654987
76	AMP metabolic process (GO:0046033)	2.80488517
77	regulation of action potential (GO:0098900)	2.76989865
78	DNA demethylation (GO:0080111)	2.76831932
79	L-fucose catabolic process (GO:0042355)	2.76260905
80	fucose catabolic process (GO:0019317)	2.76260905
81	L-fucose metabolic process (GO:0042354)	2.76260905
82	platelet dense granule organization (GO:0060155)	2.76025263
83	GTP biosynthetic process (GO:0006183)	2.75859031
84	positive regulation of action potential (GO:0045760)	2.74177693
85	positive regulation of T cell mediated immunity (GO:0002711)	2.73974761
86	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.73759308
87	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.73734488
88	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.73734488
89	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.73734488
90	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.72726110
91	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.71478688
92	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.71478688
93	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.69580813
94	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.69580813
95	multicellular organism reproduction (GO:0032504)	2.68425840
96	grooming behavior (GO:0007625)	2.67945589
97	actin nucleation (GO:0045010)	2.67307009
98	regulation of cellular amino acid metabolic process (GO:0006521)	2.66972586
99	deoxyribose phosphate catabolic process (GO:0046386)	2.65446130
100	protein polyglutamylation (GO:0018095)	2.65203711

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.09685203
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.37684542
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.83957336
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.80862398
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79370872
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.60600653
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58656965
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.32841659
9	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.24325119
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20622096
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.20411152
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06152481
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.05722109
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.04916169
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.97468564
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93812038
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.93356808
18	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.91799999
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.87974425
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.83579059
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.83190082
22	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.80690169
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68001489
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65427184
25	RUNX_20019798_ChIP-Seq_JUKART_Human	1.65174855
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.64619026
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.64526545
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.63884434
29	GATA3_26560356_Chip-Seq_TH2_Human	1.58972452
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.57396741
31	VDR_22108803_ChIP-Seq_LS180_Human	1.50661426
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49213566
33	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.47073438
34	MYB_26560356_Chip-Seq_TH2_Human	1.47066932
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40385664
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35457808
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35457808
38	GATA3_27048872_Chip-Seq_THYMUS_Human	1.35326254
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.32888661
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29570012
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29322329
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27928701
43	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26893116
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25981220
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25140739
46	AR_20517297_ChIP-Seq_VCAP_Human	1.22738370
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22734757
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22734757
49	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.22389312
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21971756
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21778370
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.17093982
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16960302
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.14178111
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13779342
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12127370
57	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.12028147
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11392872
59	MYC_19829295_ChIP-Seq_ESCs_Human	1.09527692
60	EWS_26573619_Chip-Seq_HEK293_Human	1.08769166
61	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08163130
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.08125688
63	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.07004626
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06612919
65	NCOR_22424771_ChIP-Seq_293T_Human	1.06418094
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05634678
67	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04647097
68	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04370120
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04277504
70	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03444740
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03256638
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02376432
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02138382
74	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02123856
75	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01106302
76	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00971389
77	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00091298
78	ER_23166858_ChIP-Seq_MCF-7_Human	0.98843997
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98775672
80	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97935781
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97930636
82	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97046447
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96706532
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.96706532
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95881291
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95510721
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94518755
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93355467
89	PHF8_20622853_ChIP-Seq_HELA_Human	0.93121695
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92390750
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91914368
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91106167
93	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.90980736
94	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90596368
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89087454
96	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89076050
97	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87773838
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87125281
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.86636086
100	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86543540

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.27029018
2	MP0003878_abnormal_ear_physiology	3.21344683
3	MP0005377_hearing/vestibular/ear_phenot	3.21344683
4	MP0001835_abnormal_antigen_presentation	3.21108828
5	MP0009379_abnormal_foot_pigmentation	2.67699867
6	MP0005645_abnormal_hypothalamus_physiol	2.57655659
7	MP0002102_abnormal_ear_morphology	2.41163472
8	MP0003763_abnormal_thymus_physiology	2.34666252
9	MP0003183_abnormal_peptide_metabolism	2.25941528
10	MP0002837_dystrophic_cardiac_calcinosis	2.19686184
11	MP0003195_calcinosis	2.19682589
12	MP0005646_abnormal_pituitary_gland	2.15588055
13	MP0002736_abnormal_nociception_after	2.14486342
14	MP0001905_abnormal_dopamine_level	2.11395015
15	MP0002876_abnormal_thyroid_physiology	2.08531045
16	MP0001968_abnormal_touch/_nociception	2.06532712
17	MP0002272_abnormal_nervous_system	1.97659139
18	MP0004142_abnormal_muscle_tone	1.95024519
19	MP0002234_abnormal_pharynx_morphology	1.93536665
20	MP0006292_abnormal_olfactory_placode	1.86841759
21	MP0003879_abnormal_hair_cell	1.86662613
22	MP0008872_abnormal_physiological_respon	1.85648967
23	MP0006072_abnormal_retinal_apoptosis	1.84335488
24	MP0004885_abnormal_endolymph	1.77486456
25	MP0001984_abnormal_olfaction	1.74487108
26	MP0009785_altered_susceptibility_to	1.73213859
27	MP0002653_abnormal_ependyma_morphology	1.71725124
28	MP0005551_abnormal_eye_electrophysiolog	1.71546978
29	MP0005410_abnormal_fertilization	1.65659052
30	MP0005075_abnormal_melanosome_morpholog	1.64688929
31	MP0002148_abnormal_hypersensitivity_rea	1.63396287
32	MP0002822_catalepsy	1.62229834
33	MP0005000_abnormal_immune_tolerance	1.61818794
34	MP0008995_early_reproductive_senescence	1.55821831
35	MP0002733_abnormal_thermal_nociception	1.55625956
36	MP0008875_abnormal_xenobiotic_pharmacok	1.48667011
37	MP0001800_abnormal_humoral_immune	1.47623186
38	MP0006276_abnormal_autonomic_nervous	1.45717841
39	MP0003866_abnormal_defecation	1.40975258
40	MP0003786_premature_aging	1.40970892
41	MP0001970_abnormal_pain_threshold	1.39833771
42	MP0008775_abnormal_heart_ventricle	1.38077633
43	MP0009046_muscle_twitch	1.36273574
44	MP0002723_abnormal_immune_serum	1.31159123
45	MP0001529_abnormal_vocalization	1.29368184
46	MP0005332_abnormal_amino_acid	1.28336712
47	MP0001963_abnormal_hearing_physiology	1.25483440
48	MP0001765_abnormal_ion_homeostasis	1.23758742
49	MP0006036_abnormal_mitochondrial_physio	1.22714013
50	MP0001486_abnormal_startle_reflex	1.20934531
51	MP0002638_abnormal_pupillary_reflex	1.20932353
52	MP0002420_abnormal_adaptive_immunity	1.14316604
53	MP0000685_abnormal_immune_system	1.14249150
54	MP0001986_abnormal_taste_sensitivity	1.14047956
55	MP0005084_abnormal_gallbladder_morpholo	1.13330578
56	MP0001819_abnormal_immune_cell	1.11674400
57	MP0009745_abnormal_behavioral_response	1.09294643
58	MP0001764_abnormal_homeostasis	1.06765081
59	MP0003950_abnormal_plasma_membrane	1.05709441
60	MP0003724_increased_susceptibility_to	1.04713863
61	MP0002452_abnormal_antigen_presenting	1.04013893
62	MP0004145_abnormal_muscle_electrophysio	1.03649222
63	MP0000026_abnormal_inner_ear	1.03594853
64	MP0005025_abnormal_response_to	1.03005609
65	MP0005423_abnormal_somatic_nervous	1.02365926
66	MP0004742_abnormal_vestibular_system	1.02191016
67	MP0003252_abnormal_bile_duct	1.01971220
68	MP0001485_abnormal_pinna_reflex	1.00597588
69	MP0000631_abnormal_neuroendocrine_gland	0.98720418
70	MP0002735_abnormal_chemical_nociception	0.97214048
71	MP0008877_abnormal_DNA_methylation	0.96763504
72	MP0003638_abnormal_response/metabolism_	0.96532351
73	MP0005636_abnormal_mineral_homeostasis	0.96504860
74	MP0002572_abnormal_emotion/affect_behav	0.96302339
75	MP0009764_decreased_sensitivity_to	0.95059573
76	MP0002138_abnormal_hepatobiliary_system	0.94970402
77	MP0002254_reproductive_system_inflammat	0.94891723
78	MP0003806_abnormal_nucleotide_metabolis	0.93129588
79	MP0002557_abnormal_social/conspecific_i	0.91803539
80	MP0000372_irregular_coat_pigmentation	0.91222185
81	MP0005253_abnormal_eye_physiology	0.91182081
82	MP0009333_abnormal_splenocyte_physiolog	0.89965223
83	MP0010368_abnormal_lymphatic_system	0.88568672
84	MP0002938_white_spotting	0.88361252
85	MP0005266_abnormal_metabolism	0.87679296
86	MP0003635_abnormal_synaptic_transmissio	0.82646840
87	MP0003718_maternal_effect	0.81402381
88	MP0000639_abnormal_adrenal_gland	0.81060590
89	MP0000230_abnormal_systemic_arterial	0.79601677
90	MP0001845_abnormal_inflammatory_respons	0.78954983
91	MP0000049_abnormal_middle_ear	0.78243486
92	MP0002693_abnormal_pancreas_physiology	0.77515835
93	MP0010155_abnormal_intestine_physiology	0.77385707
94	MP0004147_increased_porphyrin_level	0.75741264
95	MP0002909_abnormal_adrenal_gland	0.75189611
96	MP0000716_abnormal_immune_system	0.73685926
97	MP0002419_abnormal_innate_immunity	0.72452552
98	MP0005386_behavior/neurological_phenoty	0.72140842
99	MP0004924_abnormal_behavior	0.72140842
100	MP0003137_abnormal_impulse_conducting	0.70107110

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	4.06309247
2	Acute necrotizing encephalopathy (HP:0006965)	4.02858526
3	Molar tooth sign on MRI (HP:0002419)	3.79150824
4	Abnormality of midbrain morphology (HP:0002418)	3.79150824
5	Optic neuritis (HP:0100653)	3.77708751
6	Retrobulbar optic neuritis (HP:0100654)	3.77708751
7	Hepatocellular necrosis (HP:0001404)	3.56656433
8	Pancreatic cysts (HP:0001737)	3.54815238
9	Mitochondrial inheritance (HP:0001427)	3.47279884
10	Acute encephalopathy (HP:0006846)	3.43887750
11	Hepatic necrosis (HP:0002605)	3.40143671
12	Myositis (HP:0100614)	3.30677032
13	Progressive macrocephaly (HP:0004481)	3.26616516
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.23504820
15	Orchitis (HP:0100796)	3.12208305
16	Keratoconjunctivitis (HP:0001096)	3.10367375
17	Elevated erythrocyte sedimentation rate (HP:0003565)	2.99051149
18	Type II lissencephaly (HP:0007260)	2.96319809
19	Generalized aminoaciduria (HP:0002909)	2.92253601
20	IgG deficiency (HP:0004315)	2.90208226
21	Renal cortical cysts (HP:0000803)	2.89602955
22	Pancreatic fibrosis (HP:0100732)	2.84177913
23	Congenital stationary night blindness (HP:0007642)	2.83230023
24	Failure to thrive in infancy (HP:0001531)	2.82234649
25	Increased CSF lactate (HP:0002490)	2.80521877
26	Stomatitis (HP:0010280)	2.80414053
27	Neoplasm of head and neck (HP:0012288)	2.76816183
28	Esophageal neoplasm (HP:0100751)	2.76816183
29	Hyperglycinuria (HP:0003108)	2.71945666
30	3-Methylglutaconic aciduria (HP:0003535)	2.69803504
31	True hermaphroditism (HP:0010459)	2.69518267
32	Optic disc pallor (HP:0000543)	2.67998805
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.66613730
34	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.62764451
35	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.62764451
36	Cerebral edema (HP:0002181)	2.55137481
37	T lymphocytopenia (HP:0005403)	2.52333349
38	Retinal dysplasia (HP:0007973)	2.50721298
39	Abnormality of eosinophils (HP:0001879)	2.49716343
40	Abnormality of the renal cortex (HP:0011035)	2.48303897
41	Keratoconjunctivitis sicca (HP:0001097)	2.47341481
42	Congenital, generalized hypertrichosis (HP:0004540)	2.38428632
43	Tinnitus (HP:0000360)	2.37901230
44	Nephronophthisis (HP:0000090)	2.34466094
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31514039
46	Anencephaly (HP:0002323)	2.27644331
47	Attenuation of retinal blood vessels (HP:0007843)	2.24464646
48	Polydipsia (HP:0001959)	2.23700737
49	Abnormal drinking behavior (HP:0030082)	2.23700737
50	Medial flaring of the eyebrow (HP:0010747)	2.23223704
51	Hyperglycinemia (HP:0002154)	2.22802158
52	Increased intramyocellular lipid droplets (HP:0012240)	2.18188803
53	Delayed CNS myelination (HP:0002188)	2.17974953
54	Lactic acidosis (HP:0003128)	2.16914532
55	Abnormality of T cell number (HP:0011839)	2.15380312
56	Disproportionate short-trunk short stature (HP:0003521)	2.15285831
57	Hypoproteinemia (HP:0003075)	2.13200851
58	Abnormality of serine family amino acid metabolism (HP:0010894)	2.13068208
59	Abnormality of glycine metabolism (HP:0010895)	2.13068208
60	Severe combined immunodeficiency (HP:0004430)	2.13017591
61	Cystic liver disease (HP:0006706)	2.12801780
62	Aplastic anemia (HP:0001915)	2.10655666
63	Renal Fanconi syndrome (HP:0001994)	2.10560012
64	Flat capital femoral epiphysis (HP:0003370)	2.08375958
65	Abolished electroretinogram (ERG) (HP:0000550)	2.06347781
66	Slow-growing hair (HP:0002217)	2.01763166
67	Abnormality of hair growth rate (HP:0011363)	2.01763166
68	Congenital hepatic fibrosis (HP:0002612)	1.99880215
69	Eosinophilia (HP:0001880)	1.99851251
70	Dry hair (HP:0011359)	1.96501481
71	Limb dystonia (HP:0002451)	1.96016939
72	Postaxial foot polydactyly (HP:0001830)	1.94523145
73	Hypophosphatemic rickets (HP:0004912)	1.94157112
74	Neonatal respiratory distress (HP:0002643)	1.93521583
75	Tongue fasciculations (HP:0001308)	1.91107834
76	Increased corneal curvature (HP:0100692)	1.90485949
77	Keratoconus (HP:0000563)	1.90485949
78	Agitation (HP:0000713)	1.89179959
79	Thyroiditis (HP:0100646)	1.88313754
80	Sclerocornea (HP:0000647)	1.87308258
81	Hypotrichosis (HP:0001006)	1.87221381
82	Chronic mucocutaneous candidiasis (HP:0002728)	1.87104494
83	Recurrent cutaneous fungal infections (HP:0011370)	1.87104494
84	Brittle hair (HP:0002299)	1.86986024
85	Abnormality of T cells (HP:0002843)	1.85864754
86	Increased muscle lipid content (HP:0009058)	1.81848546
87	Increased serum lactate (HP:0002151)	1.81460414
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.80994414
89	Constricted visual fields (HP:0001133)	1.80177335
90	Broad alveolar ridges (HP:0000187)	1.79916584
91	Keratitis (HP:0000491)	1.79637328
92	Respiratory failure (HP:0002878)	1.78796216
93	Anorexia (HP:0002039)	1.76864438
94	Polyuria (HP:0000103)	1.76741347
95	Clumsiness (HP:0002312)	1.76039116
96	Macrocytic anemia (HP:0001972)	1.75792320
97	Type I diabetes mellitus (HP:0100651)	1.74773323
98	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.74211756
99	Lethargy (HP:0001254)	1.72299554
100	Chronic hepatic failure (HP:0100626)	1.69751901

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	4.52947899
2	MAP4K2	3.89043102
3	TXK	3.34552413
4	CDK19	2.69662055
5	TLK1	2.55046080
6	EPHA3	2.43537494
7	TRIM28	2.42648322
8	BMPR2	2.35390365
9	ZAK	2.33217454
10	KDR	2.32354897
11	SCYL2	2.28959322
12	FLT3	2.23770726
13	MAP4K1	2.17044906
14	CASK	2.11746048
15	KIT	2.10949746
16	TAOK3	2.06175739
17	ADRBK2	2.01947514
18	ERBB3	1.82580452
19	CSF1R	1.75460487
20	MYLK	1.74599963
21	TNK2	1.65473789
22	TESK2	1.64997332
23	PHKG1	1.64555719
24	PHKG2	1.64555719
25	TEC	1.52758701
26	FRK	1.46231969
27	NME2	1.44910417
28	MARK1	1.41883607
29	WNK4	1.36613774
30	ITK	1.33690590
31	NEK1	1.33488800
32	OXSR1	1.30067249
33	PASK	1.24911102
34	GRK1	1.07684171
35	WNK3	1.03479773
36	IKBKE	1.01743664
37	TIE1	0.98864857
38	MAP2K2	0.95152467
39	EPHB1	0.94011169
40	IKBKB	0.91509501
41	DYRK2	0.91331650
42	BCKDK	0.91127223
43	NLK	0.88645119
44	PRKCQ	0.88486613
45	ILK	0.87735124
46	BTK	0.86495561
47	RPS6KA5	0.85536196
48	SYK	0.85318166
49	RIPK4	0.85223687
50	LCK	0.84718333
51	MAPKAPK5	0.84509622
52	VRK1	0.84114178
53	GRK6	0.83629477
54	NUAK1	0.78374322
55	IGF1R	0.71421801
56	INSRR	0.70677728
57	PAK3	0.69796073
58	ROCK1	0.69611956
59	MAP3K4	0.67838758
60	OBSCN	0.64915304
61	LYN	0.63588424
62	TAF1	0.59394922
63	MATK	0.59370025
64	HCK	0.58180675
65	ADRBK1	0.57835651
66	ARAF	0.57457555
67	LRRK2	0.56553278
68	TNIK	0.56065680
69	MKNK1	0.55867884
70	DAPK1	0.55818181
71	NME1	0.53468455
72	CAMKK1	0.45401888
73	MAP2K7	0.43965387
74	PRKCE	0.43753676
75	MAPK11	0.42826010
76	TRPM7	0.42175729
77	DAPK3	0.40821903
78	MAPK13	0.40406209
79	MAP3K11	0.40279734
80	PRKACA	0.40175982
81	ZAP70	0.39646650
82	PIK3CG	0.36840232
83	CSNK1G3	0.36803505
84	CSNK1G2	0.36718015
85	PIM2	0.36323482
86	DAPK2	0.33592484
87	BCR	0.31224659
88	PRKG1	0.30621279
89	MST4	0.30039941
90	FER	0.28246266
91	INSR	0.27490673
92	SRPK1	0.27165013
93	PRKCA	0.26833544
94	CSK	0.26677284
95	PRKCI	0.26611482
96	CHUK	0.26556188
97	PRKCZ	0.26103665
98	RPS6KA3	0.25021141
99	PRKCG	0.24756556
100	IRAK4	0.23989211

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.85618212
2	Proteasome_Homo sapiens_hsa03050	3.70873118
3	Ribosome_Homo sapiens_hsa03010	3.47205972
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.33747245
5	Parkinsons disease_Homo sapiens_hsa05012	3.29643146
6	Asthma_Homo sapiens_hsa05310	2.80890294
7	Protein export_Homo sapiens_hsa03060	2.37873139
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.28136381
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.27049120
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.25991789
11	Alzheimers disease_Homo sapiens_hsa05010	2.21843287
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.02481913
13	Huntingtons disease_Homo sapiens_hsa05016	1.97657657
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.95632598
15	Allograft rejection_Homo sapiens_hsa05330	1.91813648
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.86676999
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.81199126
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.76093080
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.66415788
20	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.55718527
21	RNA polymerase_Homo sapiens_hsa03020	1.55536033
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.53469824
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53330098
24	Phototransduction_Homo sapiens_hsa04744	1.52419835
25	One carbon pool by folate_Homo sapiens_hsa00670	1.49014443
26	Basal transcription factors_Homo sapiens_hsa03022	1.48045680
27	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.44540139
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43018719
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40285437
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.35154763
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27792954
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23572065
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.19926786
34	Nicotine addiction_Homo sapiens_hsa05033	1.19764306
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15688605
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.11355645
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08610909
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01391392
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.00356270
40	RNA degradation_Homo sapiens_hsa03018	0.99529085
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97459760
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.95059424
43	Purine metabolism_Homo sapiens_hsa00230	0.94878167
44	Peroxisome_Homo sapiens_hsa04146	0.94398656
45	Olfactory transduction_Homo sapiens_hsa04740	0.93238839
46	Caffeine metabolism_Homo sapiens_hsa00232	0.92033538
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.86823913
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83663877
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.83617853
50	Butanoate metabolism_Homo sapiens_hsa00650	0.79264982
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.74460862
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74030329
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.73224031
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72457283
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.71215707
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.71150734
57	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.70532707
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69741272
59	Sulfur metabolism_Homo sapiens_hsa00920	0.69544139
60	Taste transduction_Homo sapiens_hsa04742	0.68319578
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67576162
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.66950768
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.65815138
64	Spliceosome_Homo sapiens_hsa03040	0.65622175
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64990896
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64520859
67	Retinol metabolism_Homo sapiens_hsa00830	0.64440817
68	Viral myocarditis_Homo sapiens_hsa05416	0.62353070
69	Malaria_Homo sapiens_hsa05144	0.59567191
70	Propanoate metabolism_Homo sapiens_hsa00640	0.54172803
71	Metabolic pathways_Homo sapiens_hsa01100	0.53952374
72	Salivary secretion_Homo sapiens_hsa04970	0.53168555
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52757988
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.52479335
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49594779
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49079070
77	Leishmaniasis_Homo sapiens_hsa05140	0.48960240
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48509214
79	ABC transporters_Homo sapiens_hsa02010	0.47858466
80	Insulin secretion_Homo sapiens_hsa04911	0.46656300
81	Base excision repair_Homo sapiens_hsa03410	0.45492932
82	Morphine addiction_Homo sapiens_hsa05032	0.44502736
83	Homologous recombination_Homo sapiens_hsa03440	0.44360469
84	Regulation of autophagy_Homo sapiens_hsa04140	0.44132922
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43316782
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42498140
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41884897
88	Herpes simplex infection_Homo sapiens_hsa05168	0.41626537
89	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.38651623
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35397477
91	Legionellosis_Homo sapiens_hsa05134	0.34431948
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34024490
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.33194081
94	GABAergic synapse_Homo sapiens_hsa04727	0.30819002
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28983325
96	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.23386915
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.22672350
98	Phagosome_Homo sapiens_hsa04145	0.22603592
99	Serotonergic synapse_Homo sapiens_hsa04726	0.21564563
100	Shigellosis_Homo sapiens_hsa05131	0.21201734

RPL12P30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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