ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.95383203
2	ribosomal small subunit assembly (GO:0000028)	5.52275908
3	DNA deamination (GO:0045006)	5.51505030
4	ribosomal small subunit biogenesis (GO:0042274)	5.22141460
5	viral transcription (GO:0019083)	5.21796258
6	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.19329756
7	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.14695961
8	translational termination (GO:0006415)	5.05525393
9	regulation of regulatory T cell differentiation (GO:0045589)	5.02007641
10	regulation of immunoglobulin secretion (GO:0051023)	4.89253039
11	translational elongation (GO:0006414)	4.62287631
12	regulation of chronic inflammatory response (GO:0002676)	4.61460313
13	water-soluble vitamin biosynthetic process (GO:0042364)	4.56970784
14	negative regulation of B cell apoptotic process (GO:0002903)	4.48645257
15	maturation of SSU-rRNA (GO:0030490)	4.47332033
16	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.44615626
17	cotranslational protein targeting to membrane (GO:0006613)	4.38240797
18	protein targeting to ER (GO:0045047)	4.32007018
19	regulation of isotype switching to IgG isotypes (GO:0048302)	4.28505397
20	pyrimidine nucleotide catabolic process (GO:0006244)	4.23192231
21	ATP synthesis coupled proton transport (GO:0015986)	4.22063469
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.22063469
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.20476774
24	protein localization to endoplasmic reticulum (GO:0070972)	4.13599399
25	positive regulation of isotype switching (GO:0045830)	4.03314147
26	protein complex biogenesis (GO:0070271)	3.87933269
27	protein neddylation (GO:0045116)	3.87638140
28	positive regulation of DNA recombination (GO:0045911)	3.84232065
29	ubiquinone biosynthetic process (GO:0006744)	3.83955745
30	GTP biosynthetic process (GO:0006183)	3.82921431
31	viral life cycle (GO:0019058)	3.79264049
32	cellular protein complex disassembly (GO:0043624)	3.76187154
33	positive regulation of interleukin-17 production (GO:0032740)	3.65781699
34	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.65044862
35	positive regulation of prostaglandin secretion (GO:0032308)	3.62422606
36	translational initiation (GO:0006413)	3.60478491
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.59750927
38	ribosomal large subunit biogenesis (GO:0042273)	3.59083274
39	translation (GO:0006412)	3.58802738
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.50107562
41	rRNA modification (GO:0000154)	3.46447690
42	ribonucleoprotein complex biogenesis (GO:0022613)	3.46132730
43	peptidyl-histidine modification (GO:0018202)	3.45024118
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.44920204
45	NADH dehydrogenase complex assembly (GO:0010257)	3.44920204
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.44920204
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42047643
48	myoblast migration (GO:0051451)	3.36055518
49	cellular component biogenesis (GO:0044085)	3.35329639
50	rRNA processing (GO:0006364)	3.32488314
51	ubiquinone metabolic process (GO:0006743)	3.31453582
52	quinone biosynthetic process (GO:1901663)	3.27872948
53	positive regulation of T cell apoptotic process (GO:0070234)	3.27724655
54	rRNA metabolic process (GO:0016072)	3.25837114
55	deoxyribonucleotide catabolic process (GO:0009264)	3.25569479
56	L-fucose catabolic process (GO:0042355)	3.24774769
57	fucose catabolic process (GO:0019317)	3.24774769
58	L-fucose metabolic process (GO:0042354)	3.24774769
59	positive regulation of defense response to virus by host (GO:0002230)	3.24533163
60	UTP metabolic process (GO:0046051)	3.24145689
61	cytidine metabolic process (GO:0046087)	3.21821360
62	cytidine catabolic process (GO:0006216)	3.21821360
63	cytidine deamination (GO:0009972)	3.21821360
64	proteasome assembly (GO:0043248)	3.20040700
65	respiratory electron transport chain (GO:0022904)	3.19629705
66	electron transport chain (GO:0022900)	3.18531281
67	UTP biosynthetic process (GO:0006228)	3.18201335
68	base-excision repair, AP site formation (GO:0006285)	3.17791466
69	tRNA processing (GO:0008033)	3.16396837
70	positive regulation of fatty acid transport (GO:2000193)	3.14856981
71	chaperone-mediated protein transport (GO:0072321)	3.12909050
72	respiratory chain complex IV assembly (GO:0008535)	3.12352113
73	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.12107071
74	platelet dense granule organization (GO:0060155)	3.09635634
75	regulation of prostaglandin secretion (GO:0032306)	3.09317499
76	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07087399
77	protein complex disassembly (GO:0043241)	3.06031354
78	cytochrome complex assembly (GO:0017004)	3.03293783
79	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.03028261
80	regulation of B cell apoptotic process (GO:0002902)	3.01681293
81	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.99830333
82	positive regulation of B cell mediated immunity (GO:0002714)	2.99830333
83	negative regulation of mast cell activation (GO:0033004)	2.98492051
84	rRNA methylation (GO:0031167)	2.94840522
85	CTP metabolic process (GO:0046036)	2.94092720
86	CTP biosynthetic process (GO:0006241)	2.94092720
87	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.93083475
88	negative regulation of T cell differentiation in thymus (GO:0033085)	2.89267030
89	deoxyribose phosphate catabolic process (GO:0046386)	2.87598949
90	macromolecular complex disassembly (GO:0032984)	2.86138251
91	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.85894258
92	positive regulation of T cell migration (GO:2000406)	2.85766577
93	ribosome biogenesis (GO:0042254)	2.85701036
94	regulation of interleukin-17 production (GO:0032660)	2.84883783
95	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.80068397
96	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.80068397
97	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.77893294
98	protein-cofactor linkage (GO:0018065)	2.75457067
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.75350147
100	termination of RNA polymerase III transcription (GO:0006386)	2.75350147

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.95689700
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.69554858
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.60898264
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.57559569
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.22761822
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.12727535
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.11024874
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.03170588
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.77367673
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.63537474
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.58256445
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.39733129
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30624017
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.30007001
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.16486327
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.14605972
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.05440097
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03266245
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.95446237
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.86974588
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85804210
22	VDR_22108803_ChIP-Seq_LS180_Human	1.83588167
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.81414147
24	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.81184111
25	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.79542077
26	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.79103402
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.76779901
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.76153887
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73196725
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.68693377
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.67467683
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.63635966
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.55582238
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.54620080
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.53811986
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.51405317
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47647909
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46582546
39	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.46482717
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42927900
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.41454363
42	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.39645755
43	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.38988975
44	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.36558926
45	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.32846703
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32019771
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.30159816
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.29502634
49	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.29175876
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.29125576
51	GATA3_26560356_Chip-Seq_TH2_Human	1.27596904
52	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.24547326
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24422061
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22838653
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21753078
56	ERA_21632823_ChIP-Seq_H3396_Human	1.21394810
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.20918868
58	CTCF_20526341_ChIP-Seq_ESCs_Human	1.18722503
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17135165
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.14895630
61	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13868656
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13582106
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10717915
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10070611
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.08290079
66	CIITA_25753668_ChIP-Seq_RAJI_Human	1.08128220
67	EZH2_22144423_ChIP-Seq_EOC_Human	1.08024027
68	NCOR_22424771_ChIP-Seq_293T_Human	1.07219721
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05991349
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03924155
71	AR_20517297_ChIP-Seq_VCAP_Human	1.03170516
72	BCL6_27268052_Chip-Seq_Bcells_Human	1.02440470
73	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01376162
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01278250
75	STAT1_20625510_ChIP-Seq_HELA_Human	0.99708940
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98672535
77	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98485015
78	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98485015
79	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.97359870
80	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94419423
81	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.93718547
82	EWS_26573619_Chip-Seq_HEK293_Human	0.93658905
83	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.93537154
84	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93480661
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93180565
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91854418
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91587739
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91029816
89	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90939550
90	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.89914225
91	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.88537174
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.88442354
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.87737210
94	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87379956
95	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85005835
96	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82523910
97	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.82015694
98	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.80372609
99	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.80154803
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.80083625

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.93314375
2	MP0002138_abnormal_hepatobiliary_system	4.15497046
3	MP0001835_abnormal_antigen_presentation	3.80898205
4	MP0000685_abnormal_immune_system	3.21590313
5	MP0006292_abnormal_olfactory_placode	3.15690130
6	MP0005671_abnormal_response_to	2.91038187
7	MP0000604_amyloidosis	2.35881319
8	MP0001348_abnormal_lacrimal_gland	2.19052268
9	MP0003646_muscle_fatigue	2.06418074
10	MP0002102_abnormal_ear_morphology	2.04949076
11	MP0002277_abnormal_respiratory_mucosa	2.02467726
12	MP0005377_hearing/vestibular/ear_phenot	2.02046981
13	MP0003878_abnormal_ear_physiology	2.02046981
14	MP0002653_abnormal_ependyma_morphology	1.93410254
15	MP0004885_abnormal_endolymph	1.88253884
16	MP0001188_hyperpigmentation	1.83996103
17	MP0003806_abnormal_nucleotide_metabolis	1.83532804
18	MP0001853_heart_inflammation	1.80219074
19	MP0002148_abnormal_hypersensitivity_rea	1.77311578
20	MP0004145_abnormal_muscle_electrophysio	1.71880289
21	MP0002876_abnormal_thyroid_physiology	1.67734975
22	MP0002736_abnormal_nociception_after	1.66080250
23	MP0003011_delayed_dark_adaptation	1.65740623
24	MP0001968_abnormal_touch/_nociception	1.61594792
25	MP0008877_abnormal_DNA_methylation	1.58181962
26	MP0001501_abnormal_sleep_pattern	1.58067729
27	MP0002837_dystrophic_cardiac_calcinosis	1.55116109
28	MP0002405_respiratory_system_inflammati	1.52000184
29	MP0008789_abnormal_olfactory_epithelium	1.49554524
30	MP0006072_abnormal_retinal_apoptosis	1.49480234
31	MP0009764_decreased_sensitivity_to	1.45085706
32	MP0005387_immune_system_phenotype	1.39584689
33	MP0001790_abnormal_immune_system	1.39584689
34	MP0003300_gastrointestinal_ulcer	1.35918875
35	MP0002938_white_spotting	1.35303904
36	MP0004147_increased_porphyrin_level	1.35014225
37	MP0001873_stomach_inflammation	1.34004309
38	MP0010030_abnormal_orbit_morphology	1.31693339
39	MP0001293_anophthalmia	1.30260178
40	MP0009785_altered_susceptibility_to	1.28774945
41	MP0003329_amyloid_beta_deposits	1.27179751
42	MP0003786_premature_aging	1.26964668
43	MP0000465_gastrointestinal_hemorrhage	1.26891197
44	MP0006036_abnormal_mitochondrial_physio	1.26192567
45	MP0001800_abnormal_humoral_immune	1.25779345
46	MP0008995_early_reproductive_senescence	1.24087779
47	MP0003880_abnormal_central_pattern	1.23393284
48	MP0002234_abnormal_pharynx_morphology	1.19522700
49	MP0002163_abnormal_gland_morphology	1.18995430
50	MP0008872_abnormal_physiological_respon	1.18443911
51	MP0001502_abnormal_circadian_rhythm	1.17436759
52	MP0001986_abnormal_taste_sensitivity	1.15651133
53	MP0000049_abnormal_middle_ear	1.15207120
54	MP0005551_abnormal_eye_electrophysiolog	1.14027014
55	MP0008775_abnormal_heart_ventricle	1.07084714
56	MP0005389_reproductive_system_phenotype	1.06483375
57	MP0004142_abnormal_muscle_tone	1.06038872
58	MP0005394_taste/olfaction_phenotype	1.05856576
59	MP0005499_abnormal_olfactory_system	1.05856576
60	MP0004043_abnormal_pH_regulation	1.05746278
61	MP0003436_decreased_susceptibility_to	1.05239562
62	MP0002723_abnormal_immune_serum	1.04752026
63	MP0005379_endocrine/exocrine_gland_phen	1.03390695
64	MP0008058_abnormal_DNA_repair	1.00997948
65	MP0001919_abnormal_reproductive_system	1.00592278
66	MP0006276_abnormal_autonomic_nervous	0.98185399
67	MP0005075_abnormal_melanosome_morpholog	0.97986563
68	MP0005646_abnormal_pituitary_gland	0.97921905
69	MP0005000_abnormal_immune_tolerance	0.97571253
70	MP0009333_abnormal_splenocyte_physiolog	0.95626023
71	MP0000566_synostosis	0.94312174
72	MP0005645_abnormal_hypothalamus_physiol	0.91145252
73	MP0005025_abnormal_response_to	0.91051272
74	MP0001485_abnormal_pinna_reflex	0.90603396
75	MP0001663_abnormal_digestive_system	0.90114191
76	MP0002420_abnormal_adaptive_immunity	0.89949452
77	MP0001819_abnormal_immune_cell	0.89779424
78	MP0003763_abnormal_thymus_physiology	0.89548637
79	MP0000372_irregular_coat_pigmentation	0.87166612
80	MP0001119_abnormal_female_reproductive	0.85552817
81	MP0005084_abnormal_gallbladder_morpholo	0.84557166
82	MP0002160_abnormal_reproductive_system	0.84066855
83	MP0002254_reproductive_system_inflammat	0.81993169
84	MP0002272_abnormal_nervous_system	0.80454630
85	MP0008875_abnormal_xenobiotic_pharmacok	0.78735860
86	MP0003693_abnormal_embryo_hatching	0.78024789
87	MP0003195_calcinosis	0.77439092
88	MP0005332_abnormal_amino_acid	0.76689634
89	MP0003283_abnormal_digestive_organ	0.73849597
90	MP0000631_abnormal_neuroendocrine_gland	0.72932911
91	MP0002452_abnormal_antigen_presenting	0.71869402
92	MP0005410_abnormal_fertilization	0.71737888
93	MP0002693_abnormal_pancreas_physiology	0.71022756
94	MP0002210_abnormal_sex_determination	0.70528087
95	MP0003787_abnormal_imprinting	0.69994915
96	MP0002733_abnormal_thermal_nociception	0.69418718
97	MP0004133_heterotaxia	0.68113549
98	MP0004019_abnormal_vitamin_homeostasis	0.67686300
99	MP0006054_spinal_hemorrhage	0.67648359
100	MP0001845_abnormal_inflammatory_respons	0.66312612

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	5.64452605
2	Acute necrotizing encephalopathy (HP:0006965)	4.39767949
3	Type 2 muscle fiber atrophy (HP:0003554)	4.15138531
4	Mitochondrial inheritance (HP:0001427)	3.99614757
5	Increased IgM level (HP:0003496)	3.97504617
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.91671679
7	Acute encephalopathy (HP:0006846)	3.80387470
8	Muscle fiber atrophy (HP:0100295)	3.74532243
9	Increased CSF lactate (HP:0002490)	3.60794658
10	Hepatocellular necrosis (HP:0001404)	3.60428203
11	Hepatic necrosis (HP:0002605)	3.55821576
12	Progressive macrocephaly (HP:0004481)	3.51203187
13	Reticulocytopenia (HP:0001896)	3.50109258
14	Type II lissencephaly (HP:0007260)	3.26877541
15	Prostate neoplasm (HP:0100787)	3.12442975
16	3-Methylglutaconic aciduria (HP:0003535)	3.10094861
17	Cerebral edema (HP:0002181)	3.05470451
18	Increased serum lactate (HP:0002151)	3.04964852
19	Nonprogressive disorder (HP:0003680)	2.99818604
20	Abnormality of midbrain morphology (HP:0002418)	2.98900601
21	Molar tooth sign on MRI (HP:0002419)	2.98900601
22	Abnormality of the prostate (HP:0008775)	2.95292862
23	Elevated erythrocyte sedimentation rate (HP:0003565)	2.94040539
24	Increased hepatocellular lipid droplets (HP:0006565)	2.89186514
25	Pancreatic cysts (HP:0001737)	2.87868032
26	Amniotic constriction ring (HP:0009775)	2.86511609
27	Abnormality of placental membranes (HP:0011409)	2.86511609
28	Methylmalonic acidemia (HP:0002912)	2.77698638
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.74373246
30	Lipid accumulation in hepatocytes (HP:0006561)	2.73565549
31	Abnormality of magnesium homeostasis (HP:0004921)	2.72629272
32	Abnormality of the renal cortex (HP:0011035)	2.66714659
33	Abnormality of T cell physiology (HP:0011840)	2.66519319
34	Hypomagnesemia (HP:0002917)	2.64620479
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.60716823
36	Pancreatic fibrosis (HP:0100732)	2.55403070
37	Glycosuria (HP:0003076)	2.55183310
38	Abnormality of urine glucose concentration (HP:0011016)	2.55183310
39	Chronic hepatic failure (HP:0100626)	2.53534307
40	Macrocytic anemia (HP:0001972)	2.52571454
41	Abolished electroretinogram (ERG) (HP:0000550)	2.52088755
42	Nephronophthisis (HP:0000090)	2.51090807
43	IgG deficiency (HP:0004315)	2.51021167
44	Retinal dysplasia (HP:0007973)	2.50623950
45	Renal Fanconi syndrome (HP:0001994)	2.50512183
46	Optic disc pallor (HP:0000543)	2.47580080
47	Renal cortical cysts (HP:0000803)	2.43775036
48	Microvesicular hepatic steatosis (HP:0001414)	2.43620513
49	Sclerocornea (HP:0000647)	2.43365729
50	Lactic acidosis (HP:0003128)	2.43274313
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.42288153
52	True hermaphroditism (HP:0010459)	2.41101450
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.38253082
54	Methylmalonic aciduria (HP:0012120)	2.37372338
55	Abnormality of T cells (HP:0002843)	2.30335114
56	Increased intramyocellular lipid droplets (HP:0012240)	2.30289038
57	Lethargy (HP:0001254)	2.29262983
58	Abnormal number of erythroid precursors (HP:0012131)	2.29061776
59	Exercise intolerance (HP:0003546)	2.25342956
60	Exertional dyspnea (HP:0002875)	2.17617171
61	Respiratory failure (HP:0002878)	2.17556943
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13542589
63	Tubular atrophy (HP:0000092)	2.12163434
64	Neutropenia (HP:0001875)	2.10981559
65	Occipital encephalocele (HP:0002085)	2.05833845
66	Rib fusion (HP:0000902)	2.05383487
67	Abnormality of the neuromuscular junction (HP:0003398)	2.05103952
68	Fatigable weakness (HP:0003473)	2.05103952
69	Pallor (HP:0000980)	2.05090678
70	Weak cry (HP:0001612)	2.04171391
71	Hypoplasia of the uterus (HP:0000013)	2.03917324
72	Dyschromatopsia (HP:0007641)	2.02977032
73	Hyperglycinemia (HP:0002154)	2.02790886
74	Abnormality of the renal medulla (HP:0100957)	2.02228913
75	Increased muscle lipid content (HP:0009058)	1.99975892
76	Ketosis (HP:0001946)	1.99284240
77	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.93956195
78	Colon cancer (HP:0003003)	1.93844747
79	Absent thumb (HP:0009777)	1.93433785
80	Polyuria (HP:0000103)	1.92408201
81	Leukodystrophy (HP:0002415)	1.90270852
82	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.84437141
83	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.83301415
84	Dicarboxylic aciduria (HP:0003215)	1.81152290
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.81152290
86	Delayed CNS myelination (HP:0002188)	1.79287453
87	Pancytopenia (HP:0001876)	1.79163068
88	Abnormal drinking behavior (HP:0030082)	1.75905716
89	Polydipsia (HP:0001959)	1.75905716
90	Decreased central vision (HP:0007663)	1.75706611
91	Asplenia (HP:0001746)	1.75008523
92	Abnormality of T cell number (HP:0011839)	1.74209811
93	Patent foramen ovale (HP:0001655)	1.73691124
94	Congenital, generalized hypertrichosis (HP:0004540)	1.73224289
95	Abnormality of male internal genitalia (HP:0000022)	1.71762933
96	Cerebellar dysplasia (HP:0007033)	1.69954004
97	Nausea (HP:0002018)	1.68033241
98	Cleft eyelid (HP:0000625)	1.67420740
99	Severe muscular hypotonia (HP:0006829)	1.66968750
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.65967312

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.94397783
2	ZAK	3.68263827
3	TXK	3.55065938
4	PINK1	3.40139776
5	BMPR1B	3.19804510
6	TLK1	2.84970776
7	ADRBK2	2.54399631
8	BCKDK	2.53576741
9	NUAK1	2.48163231
10	GRK1	2.29181155
11	MAP4K1	2.06314434
12	VRK1	2.04584442
13	CDK19	1.87773421
14	MUSK	1.86230319
15	TAF1	1.81503882
16	NME2	1.65580847
17	KIT	1.62181283
18	WNK4	1.52467738
19	NME1	1.52373111
20	PHKG1	1.51492948
21	PHKG2	1.51492948
22	MAPKAPK3	1.39999183
23	PDK2	1.38311274
24	TEC	1.35644118
25	IKBKE	1.26021387
26	SYK	1.24952401
27	PASK	1.21684997
28	DYRK2	1.16969316
29	KDR	1.14051359
30	SMG1	1.13682557
31	IKBKB	1.13113222
32	EIF2AK2	1.10775852
33	PBK	1.07742757
34	MST4	1.07022331
35	PRKCQ	1.01971183
36	DAPK1	1.00977970
37	MKNK2	1.00638713
38	CSK	0.99306638
39	FRK	0.95072507
40	TAOK3	0.93104588
41	GRK6	0.92654018
42	ITK	0.90028145
43	PLK3	0.85457045
44	STK16	0.84338639
45	WNK3	0.83120956
46	PRKG2	0.82405404
47	BTK	0.82168753
48	FES	0.80465247
49	MAPK13	0.78677320
50	CDK8	0.74403600
51	EIF2AK1	0.73922146
52	LRRK2	0.73781756
53	OXSR1	0.72695155
54	BUB1	0.69173285
55	EIF2AK3	0.68724677
56	TBK1	0.68331159
57	PRKD3	0.66186790
58	MAPKAPK5	0.65078660
59	GRK5	0.63030546
60	SCYL2	0.60983093
61	MAP3K4	0.60701368
62	CHEK2	0.60363903
63	DAPK2	0.60179783
64	CSNK1G3	0.58179153
65	ABL2	0.57193986
66	PRKCG	0.55233140
67	RPS6KA5	0.55102736
68	MAP3K9	0.54480576
69	PLK1	0.54398179
70	CSNK2A2	0.53500981
71	OBSCN	0.53056029
72	CSNK1G1	0.52788917
73	TRIM28	0.51949734
74	NEK1	0.51657233
75	PIK3CG	0.49467915
76	EPHB2	0.48864243
77	PAK3	0.48625260
78	BRSK2	0.47137762
79	ADRBK1	0.45824209
80	DAPK3	0.45691253
81	TIE1	0.45586312
82	TYK2	0.45226889
83	CSNK1G2	0.45182213
84	LYN	0.45171558
85	MAPK15	0.44354298
86	TNIK	0.43557844
87	AURKB	0.43403154
88	INSRR	0.43061803
89	LCK	0.42348472
90	PRKCE	0.41893187
91	FLT3	0.41406202
92	MAP2K2	0.41278095
93	ATR	0.41018981
94	CSNK2A1	0.40471343
95	PRKCI	0.40409453
96	PIK3CA	0.39960914
97	SRPK1	0.39767561
98	WNK1	0.38735983
99	TNK2	0.37706975
100	PRKCA	0.37618674

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.58406972
2	Asthma_Homo sapiens_hsa05310	3.97123906
3	Allograft rejection_Homo sapiens_hsa05330	3.64979009
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.23962067
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01950452
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.99876300
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.98891267
8	Proteasome_Homo sapiens_hsa03050	2.86438011
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64388415
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.49930631
11	RNA polymerase_Homo sapiens_hsa03020	2.45591809
12	Parkinsons disease_Homo sapiens_hsa05012	2.36579218
13	Sulfur relay system_Homo sapiens_hsa04122	2.19759509
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17074019
15	Primary immunodeficiency_Homo sapiens_hsa05340	2.05498558
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80634560
17	Huntingtons disease_Homo sapiens_hsa05016	1.66609776
18	Alzheimers disease_Homo sapiens_hsa05010	1.59240283
19	Basal transcription factors_Homo sapiens_hsa03022	1.57868905
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57350705
21	Protein export_Homo sapiens_hsa03060	1.55911146
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.48063225
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.47081380
24	Folate biosynthesis_Homo sapiens_hsa00790	1.47049360
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.46331798
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.42345649
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41434695
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40262011
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36512348
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.32159438
31	RNA degradation_Homo sapiens_hsa03018	1.31414554
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.31251894
33	Sulfur metabolism_Homo sapiens_hsa00920	1.10754171
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.05592214
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03872494
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.01329112
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00992497
38	Viral myocarditis_Homo sapiens_hsa05416	1.00543847
39	Ether lipid metabolism_Homo sapiens_hsa00565	0.98266081
40	Antigen processing and presentation_Homo sapiens_hsa04612	0.97480464
41	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.96723128
42	One carbon pool by folate_Homo sapiens_hsa00670	0.94106973
43	Base excision repair_Homo sapiens_hsa03410	0.90240302
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.82181889
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.81620135
46	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79436908
47	Purine metabolism_Homo sapiens_hsa00230	0.79101354
48	Regulation of autophagy_Homo sapiens_hsa04140	0.77904252
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76981211
50	Mismatch repair_Homo sapiens_hsa03430	0.73511257
51	Propanoate metabolism_Homo sapiens_hsa00640	0.72430678
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.71706720
53	Caffeine metabolism_Homo sapiens_hsa00232	0.71213021
54	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.71045532
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.69718938
56	Homologous recombination_Homo sapiens_hsa03440	0.65928840
57	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62517806
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61810273
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.58678927
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58312923
61	Herpes simplex infection_Homo sapiens_hsa05168	0.57081333
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.56578734
63	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55848328
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.55414973
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54516547
66	Metabolic pathways_Homo sapiens_hsa01100	0.53814526
67	Spliceosome_Homo sapiens_hsa03040	0.52199437
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51165213
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.50878273
70	RNA transport_Homo sapiens_hsa03013	0.50246305
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50113346
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48995278
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48881318
74	Peroxisome_Homo sapiens_hsa04146	0.45777308
75	Phototransduction_Homo sapiens_hsa04744	0.45260574
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41865018
77	Fatty acid elongation_Homo sapiens_hsa00062	0.40419344
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38214209
79	Retinol metabolism_Homo sapiens_hsa00830	0.37862912
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36854715
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35619685
82	Leishmaniasis_Homo sapiens_hsa05140	0.35037914
83	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34192364
84	HTLV-I infection_Homo sapiens_hsa05166	0.30245253
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28963279
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.28666392
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27550892
88	Insulin secretion_Homo sapiens_hsa04911	0.25511909
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.25160062
90	DNA replication_Homo sapiens_hsa03030	0.23384820
91	Measles_Homo sapiens_hsa05162	0.22288232
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.21067963
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.21017840
94	Olfactory transduction_Homo sapiens_hsa04740	0.21015298
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.19546211
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.18677114
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.18267699
98	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.17265415
99	Taste transduction_Homo sapiens_hsa04742	0.17216677
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.16927363

RPL12P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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