ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.34141690
2	ribosomal small subunit biogenesis (GO:0042274)	7.15199010
3	translational termination (GO:0006415)	7.00791228
4	maturation of SSU-rRNA (GO:0030490)	6.53176010
5	ribosomal small subunit assembly (GO:0000028)	6.42944187
6	translational elongation (GO:0006414)	6.12361853
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.04268880
8	cotranslational protein targeting to membrane (GO:0006613)	5.99888767
9	protein targeting to ER (GO:0045047)	5.94520734
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.68802349
11	protein localization to endoplasmic reticulum (GO:0070972)	5.59218067
12	ATP synthesis coupled proton transport (GO:0015986)	5.46762170
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.46762170
14	cellular protein complex disassembly (GO:0043624)	5.28546008
15	viral life cycle (GO:0019058)	5.21135193
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.03128662
17	behavioral response to nicotine (GO:0035095)	5.01552206
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.76705310
19	chaperone-mediated protein transport (GO:0072321)	4.72528326
20	translational initiation (GO:0006413)	4.69516010
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.44941766
22	NADH dehydrogenase complex assembly (GO:0010257)	4.44941766
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.44941766
24	ribosomal large subunit biogenesis (GO:0042273)	4.43255998
25	protein complex biogenesis (GO:0070271)	4.38694178
26	protein complex disassembly (GO:0043241)	4.38585403
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.38231222
28	DNA deamination (GO:0045006)	4.33287654
29	GTP biosynthetic process (GO:0006183)	4.26751011
30	protein neddylation (GO:0045116)	4.24646947
31	macromolecular complex disassembly (GO:0032984)	4.13958793
32	translation (GO:0006412)	4.11922528
33	mitochondrial respiratory chain complex assembly (GO:0033108)	4.02790323
34	protein targeting to membrane (GO:0006612)	4.01794650
35	respiratory electron transport chain (GO:0022904)	3.93206521
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.92191655
37	electron transport chain (GO:0022900)	3.90172938
38	ribonucleoprotein complex biogenesis (GO:0022613)	3.73005310
39	cellular component biogenesis (GO:0044085)	3.71347618
40	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.68727629
41	regulation of mitotic spindle checkpoint (GO:1903504)	3.68727629
42	UTP biosynthetic process (GO:0006228)	3.63294031
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.63169605
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.50449702
45	termination of RNA polymerase III transcription (GO:0006386)	3.50449702
46	regulation of isotype switching to IgG isotypes (GO:0048302)	3.48708671
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.47846758
48	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.47649772
49	mRNA catabolic process (GO:0006402)	3.45269204
50	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.42875723
51	regulation of immunoglobulin secretion (GO:0051023)	3.39949619
52	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.34073578
53	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.32941349
54	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.31179780
55	UTP metabolic process (GO:0046051)	3.30309155
56	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.25517911
57	rRNA processing (GO:0006364)	3.23893354
58	ATP biosynthetic process (GO:0006754)	3.22670434
59	rRNA metabolic process (GO:0016072)	3.20346609
60	protein-cofactor linkage (GO:0018065)	3.14400017
61	RNA catabolic process (GO:0006401)	3.11732626
62	substrate-independent telencephalic tangential migration (GO:0021826)	3.08913466
63	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.08913466
64	positive regulation of fatty acid transport (GO:2000193)	3.07768582
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07609824
66	hydrogen ion transmembrane transport (GO:1902600)	3.05442577
67	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.99549795
68	nonmotile primary cilium assembly (GO:0035058)	2.94812286
69	protein polyglutamylation (GO:0018095)	2.94499332
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.91658028
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.91658028
72	pyrimidine nucleotide catabolic process (GO:0006244)	2.90685416
73	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.89824076
74	CTP metabolic process (GO:0046036)	2.88911868
75	CTP biosynthetic process (GO:0006241)	2.88911868
76	positive regulation of prostaglandin secretion (GO:0032308)	2.88569238
77	tRNA processing (GO:0008033)	2.87160934
78	pseudouridine synthesis (GO:0001522)	2.82461449
79	proton transport (GO:0015992)	2.80644158
80	guanosine-containing compound biosynthetic process (GO:1901070)	2.78905167
81	positive regulation of icosanoid secretion (GO:0032305)	2.77495238
82	detection of light stimulus involved in sensory perception (GO:0050962)	2.76218473
83	detection of light stimulus involved in visual perception (GO:0050908)	2.76218473
84	protein targeting to mitochondrion (GO:0006626)	2.75873378
85	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.75161284
86	establishment of protein localization to mitochondrion (GO:0072655)	2.74944267
87	respiratory chain complex IV assembly (GO:0008535)	2.74938510
88	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.74484829
89	rRNA catabolic process (GO:0016075)	2.73986346
90	protein targeting (GO:0006605)	2.73367352
91	hydrogen transport (GO:0006818)	2.73287218
92	rRNA modification (GO:0000154)	2.72994369
93	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.71605618
94	iron-sulfur cluster assembly (GO:0016226)	2.69296931
95	metallo-sulfur cluster assembly (GO:0031163)	2.69296931
96	regulation of cilium movement (GO:0003352)	2.66800910
97	nucleoside triphosphate biosynthetic process (GO:0009142)	2.66660904
98	establishment of protein localization to membrane (GO:0090150)	2.64795088
99	positive regulation of defense response to virus by host (GO:0002230)	2.64472583
100	myoblast migration (GO:0051451)	2.63409289

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.28593835
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.02262958
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.93085086
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.92916408
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.25422293
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.11106587
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.96183647
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.96134908
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.79067900
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.30811756
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23206933
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.18002535
13	TTF2_22483619_ChIP-Seq_HELA_Human	1.95222175
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.94841831
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90363055
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.83653164
17	FOXP3_21729870_ChIP-Seq_TREG_Human	1.81173248
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.75962038
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.74474279
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74419801
21	XRN2_22483619_ChIP-Seq_HELA_Human	1.68579747
22	VDR_22108803_ChIP-Seq_LS180_Human	1.67154644
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.65077824
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63755236
25	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.59161523
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.57906925
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.57434938
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57324476
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55715983
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55055085
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.50572042
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.48513896
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.44864346
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.44070112
35	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.40129248
36	EWS_26573619_Chip-Seq_HEK293_Human	1.38778289
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38247174
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36958621
39	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.36817308
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.35601058
41	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.35598595
42	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.29975443
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.28600183
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28379778
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28111008
46	ERA_21632823_ChIP-Seq_H3396_Human	1.26376309
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25316038
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24885381
49	NCOR_22424771_ChIP-Seq_293T_Human	1.24194351
50	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.24173751
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.23483867
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.22718561
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22499144
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21320146
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.20625880
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16296384
57	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15496658
58	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.14300877
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10099294
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09211515
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09082372
62	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.06538882
63	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05158029
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04377630
65	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04215122
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04053311
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02924035
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02524223
69	AR_20517297_ChIP-Seq_VCAP_Human	1.02239734
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02126773
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.01854110
72	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98092067
73	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.98068345
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.97822395
75	MYC_19829295_ChIP-Seq_ESCs_Human	0.97198300
76	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.96875855
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95802995
78	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95765059
79	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95199929
80	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.94636206
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94311791
82	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.93580585
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92468217
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92017236
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92017236
86	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.91248151
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.90447560
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89722605
89	BCL6_27268052_Chip-Seq_Bcells_Human	0.89211036
90	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.88653940
91	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88572334
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.88560094
93	STAT1_20625510_ChIP-Seq_HELA_Human	0.87969793
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87910200
95	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.87226113
96	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.87095756
97	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85943611
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84469768
99	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.83925896
100	P300_27268052_Chip-Seq_Bcells_Human	0.83573644

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.78271538
2	MP0006292_abnormal_olfactory_placode	3.10746691
3	MP0005377_hearing/vestibular/ear_phenot	2.63104654
4	MP0003878_abnormal_ear_physiology	2.63104654
5	MP0005671_abnormal_response_to	2.36874238
6	MP0003646_muscle_fatigue	2.36021065
7	MP0008877_abnormal_DNA_methylation	2.32667745
8	MP0002163_abnormal_gland_morphology	2.31801977
9	MP0004142_abnormal_muscle_tone	2.31261598
10	MP0005646_abnormal_pituitary_gland	2.22059794
11	MP0008872_abnormal_physiological_respon	2.05260500
12	MP0008789_abnormal_olfactory_epithelium	1.95206448
13	MP0001873_stomach_inflammation	1.92727736
14	MP0006072_abnormal_retinal_apoptosis	1.89574894
15	MP0000685_abnormal_immune_system	1.88592904
16	MP0001348_abnormal_lacrimal_gland	1.87280828
17	MP0003787_abnormal_imprinting	1.83528209
18	MP0005551_abnormal_eye_electrophysiolog	1.80325339
19	MP0004885_abnormal_endolymph	1.80116544
20	MP0005379_endocrine/exocrine_gland_phen	1.76316372
21	MP0008875_abnormal_xenobiotic_pharmacok	1.70238700
22	MP0004147_increased_porphyrin_level	1.62206649
23	MP0002638_abnormal_pupillary_reflex	1.60227835
24	MP0001968_abnormal_touch/_nociception	1.58509909
25	MP0002102_abnormal_ear_morphology	1.55076941
26	MP0006276_abnormal_autonomic_nervous	1.53845303
27	MP0005423_abnormal_somatic_nervous	1.49650284
28	MP0003195_calcinosis	1.49197067
29	MP0001529_abnormal_vocalization	1.46455517
30	MP0002876_abnormal_thyroid_physiology	1.46363037
31	MP0004742_abnormal_vestibular_system	1.46191623
32	MP0002736_abnormal_nociception_after	1.44961720
33	MP0004145_abnormal_muscle_electrophysio	1.41986178
34	MP0009764_decreased_sensitivity_to	1.38807567
35	MP0005394_taste/olfaction_phenotype	1.37690164
36	MP0005499_abnormal_olfactory_system	1.37690164
37	MP0001293_anophthalmia	1.36133797
38	MP0002272_abnormal_nervous_system	1.35609614
39	MP0001835_abnormal_antigen_presentation	1.34426150
40	MP0009333_abnormal_splenocyte_physiolog	1.33821820
41	MP0003011_delayed_dark_adaptation	1.31916867
42	MP0000631_abnormal_neuroendocrine_gland	1.25365485
43	MP0005645_abnormal_hypothalamus_physiol	1.24282428
44	MP0001984_abnormal_olfaction	1.21754728
45	MP0002837_dystrophic_cardiac_calcinosis	1.20174389
46	MP0009745_abnormal_behavioral_response	1.15943754
47	MP0000049_abnormal_middle_ear	1.14251317
48	MP0003786_premature_aging	1.12385179
49	MP0002095_abnormal_skin_pigmentation	1.09913545
50	MP0002822_catalepsy	1.09877332
51	MP0003123_paternal_imprinting	1.09128376
52	MP0001485_abnormal_pinna_reflex	1.08857102
53	MP0001905_abnormal_dopamine_level	1.08023404
54	MP0001970_abnormal_pain_threshold	1.05962989
55	MP0009046_muscle_twitch	1.04120588
56	MP0002148_abnormal_hypersensitivity_rea	1.03202000
57	MP0008058_abnormal_DNA_repair	1.02828698
58	MP0002938_white_spotting	1.02401304
59	MP0002557_abnormal_social/conspecific_i	1.01423753
60	MP0005389_reproductive_system_phenotype	1.00820416
61	MP0001800_abnormal_humoral_immune	1.00335203
62	MP0003186_abnormal_redox_activity	0.98707940
63	MP0002735_abnormal_chemical_nociception	0.98525370
64	MP0005253_abnormal_eye_physiology	0.98360397
65	MP0003806_abnormal_nucleotide_metabolis	0.97683361
66	MP0002160_abnormal_reproductive_system	0.97219279
67	MP0005195_abnormal_posterior_eye	0.95124585
68	MP0003693_abnormal_embryo_hatching	0.93623538
69	MP0005084_abnormal_gallbladder_morpholo	0.93528978
70	MP0005410_abnormal_fertilization	0.92407942
71	MP0002138_abnormal_hepatobiliary_system	0.91072227
72	MP0010386_abnormal_urinary_bladder	0.87193731
73	MP0001919_abnormal_reproductive_system	0.86655417
74	MP0001501_abnormal_sleep_pattern	0.86400606
75	MP0001502_abnormal_circadian_rhythm	0.86265035
76	MP0002733_abnormal_thermal_nociception	0.85756756
77	MP0000026_abnormal_inner_ear	0.85348908
78	MP0001790_abnormal_immune_system	0.84208289
79	MP0005387_immune_system_phenotype	0.84208289
80	MP0002572_abnormal_emotion/affect_behav	0.82879896
81	MP0003122_maternal_imprinting	0.82193315
82	MP0001440_abnormal_grooming_behavior	0.81853171
83	MP0003880_abnormal_central_pattern	0.80788914
84	MP0001486_abnormal_startle_reflex	0.80738436
85	MP0005332_abnormal_amino_acid	0.79794473
86	MP0002277_abnormal_respiratory_mucosa	0.79660755
87	MP0002752_abnormal_somatic_nervous	0.79488800
88	MP0003136_yellow_coat_color	0.78794400
89	MP0002063_abnormal_learning/memory/cond	0.78744923
90	MP0002405_respiratory_system_inflammati	0.78282317
91	MP0006036_abnormal_mitochondrial_physio	0.76703045
92	MP0002184_abnormal_innervation	0.75307128
93	MP0002210_abnormal_sex_determination	0.74988688
94	MP0002723_abnormal_immune_serum	0.74705224
95	MP0002653_abnormal_ependyma_morphology	0.73653214
96	MP0010030_abnormal_orbit_morphology	0.72893344
97	MP0009785_altered_susceptibility_to	0.72679858
98	MP0001765_abnormal_ion_homeostasis	0.72356284
99	MP0001963_abnormal_hearing_physiology	0.72145223
100	MP0002693_abnormal_pancreas_physiology	0.71953943

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.83833506
2	Mitochondrial inheritance (HP:0001427)	4.51011151
3	Reticulocytopenia (HP:0001896)	4.48616579
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.43096455
5	Increased hepatocellular lipid droplets (HP:0006565)	4.09664373
6	Acute encephalopathy (HP:0006846)	4.06308886
7	Increased CSF lactate (HP:0002490)	3.96497541
8	Lipid accumulation in hepatocytes (HP:0006561)	3.89267106
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.84993838
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.82002444
11	Progressive macrocephaly (HP:0004481)	3.79559389
12	3-Methylglutaconic aciduria (HP:0003535)	3.72047749
13	Molar tooth sign on MRI (HP:0002419)	3.60834348
14	Abnormality of midbrain morphology (HP:0002418)	3.60834348
15	Hepatocellular necrosis (HP:0001404)	3.59093012
16	Macrocytic anemia (HP:0001972)	3.58070095
17	Increased intramyocellular lipid droplets (HP:0012240)	3.53529216
18	Renal Fanconi syndrome (HP:0001994)	3.42485272
19	Abnormal rod and cone electroretinograms (HP:0008323)	3.35425089
20	Pancreatic fibrosis (HP:0100732)	3.34810652
21	Abnormal number of erythroid precursors (HP:0012131)	3.24622879
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.16342231
23	Hepatic necrosis (HP:0002605)	3.14543887
24	Pancreatic cysts (HP:0001737)	3.14441406
25	Increased muscle lipid content (HP:0009058)	3.05708864
26	Congenital stationary night blindness (HP:0007642)	3.03970347
27	Rib fusion (HP:0000902)	3.03267764
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.01423675
29	Cerebral edema (HP:0002181)	2.98481933
30	Increased serum lactate (HP:0002151)	2.96570553
31	Stomatitis (HP:0010280)	2.76810153
32	Type II lissencephaly (HP:0007260)	2.76315808
33	Pallor (HP:0000980)	2.73419810
34	True hermaphroditism (HP:0010459)	2.66700643
35	Exertional dyspnea (HP:0002875)	2.66477715
36	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.58985994
37	Chronic bronchitis (HP:0004469)	2.55399704
38	Optic disc pallor (HP:0000543)	2.54072991
39	IgG deficiency (HP:0004315)	2.53529116
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.52708026
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.52708026
42	Septo-optic dysplasia (HP:0100842)	2.50927357
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.50714471
44	Pendular nystagmus (HP:0012043)	2.48846244
45	Lactic acidosis (HP:0003128)	2.45016381
46	Abnormality of the pons (HP:0007361)	2.44536707
47	Hypoplasia of the pons (HP:0012110)	2.34852888
48	Agitation (HP:0000713)	2.26290580
49	Leukodystrophy (HP:0002415)	2.25068750
50	Cystic liver disease (HP:0006706)	2.23119531
51	Absent/shortened dynein arms (HP:0200106)	2.21595053
52	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21595053
53	Abnormality of renal resorption (HP:0011038)	2.21069830
54	Absent thumb (HP:0009777)	2.19006500
55	Abnormality of alanine metabolism (HP:0010916)	2.16978440
56	Hyperalaninemia (HP:0003348)	2.16978440
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16978440
58	Exercise intolerance (HP:0003546)	2.16631124
59	Nephronophthisis (HP:0000090)	2.15817845
60	Elevated erythrocyte sedimentation rate (HP:0003565)	2.12746622
61	Abnormal respiratory motile cilium physiology (HP:0012261)	2.12608202
62	Medial flaring of the eyebrow (HP:0010747)	2.12055446
63	Congenital, generalized hypertrichosis (HP:0004540)	2.09951258
64	Abnormality of urine glucose concentration (HP:0011016)	2.07193735
65	Glycosuria (HP:0003076)	2.07193735
66	Respiratory failure (HP:0002878)	2.07049623
67	Abnormality of the renal cortex (HP:0011035)	2.06538919
68	Respiratory difficulties (HP:0002880)	2.02856260
69	Sclerocornea (HP:0000647)	2.02794667
70	Anencephaly (HP:0002323)	2.01354101
71	Polydipsia (HP:0001959)	1.99257054
72	Abnormal drinking behavior (HP:0030082)	1.99257054
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.98784428
74	Oligodactyly (hands) (HP:0001180)	1.96433981
75	Chronic hepatic failure (HP:0100626)	1.95050127
76	Lethargy (HP:0001254)	1.92121372
77	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.91967600
78	Rhinitis (HP:0012384)	1.91334644
79	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.89529982
80	Neutropenia (HP:0001875)	1.87974003
81	Hypoplasia of the radius (HP:0002984)	1.87210333
82	Depressed nasal ridge (HP:0000457)	1.86249190
83	Abolished electroretinogram (ERG) (HP:0000550)	1.85701943
84	Hyperphosphaturia (HP:0003109)	1.85315059
85	Asplenia (HP:0001746)	1.85029645
86	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.84973185
87	Decreased circulating renin level (HP:0003351)	1.82934180
88	Methylmalonic acidemia (HP:0002912)	1.82604890
89	Abnormal ciliary motility (HP:0012262)	1.80910780
90	Large for gestational age (HP:0001520)	1.79457263
91	Concave nail (HP:0001598)	1.79149888
92	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.78964536
93	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.78964536
94	Oligodactyly (HP:0012165)	1.75571060
95	Chorioretinal atrophy (HP:0000533)	1.74940698
96	Constricted visual fields (HP:0001133)	1.74687346
97	Pigmentary retinal degeneration (HP:0001146)	1.73366231
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72337309
99	Abnormality of the renal medulla (HP:0100957)	1.72163151
100	Methylmalonic aciduria (HP:0012120)	1.71775617

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.56987631
2	WNK4	3.68269985
3	TLK1	2.98501499
4	ZAK	2.66402100
5	CAMKK2	2.59094534
6	BCKDK	2.57676767
7	ADRBK2	2.54016293
8	NME1	2.24811327
9	STK16	2.19312456
10	GRK1	2.10275669
11	DYRK2	2.02230070
12	FRK	1.91496664
13	PINK1	1.88105393
14	NME2	1.86126537
15	MAP4K2	1.84492681
16	CAMK1D	1.75959703
17	STK39	1.73996553
18	NUAK1	1.68858273
19	MAP4K1	1.59213507
20	LRRK2	1.56820324
21	PASK	1.41333604
22	CAMKK1	1.25277400
23	WNK3	1.22801018
24	KDR	1.21584512
25	VRK2	1.21275088
26	BLK	1.19822543
27	MAP2K6	1.18770086
28	ITK	1.18723349
29	CDK19	1.17948790
30	OXSR1	1.17110777
31	TEC	1.16342913
32	PAK3	1.10657102
33	VRK1	1.07760779
34	NTRK2	1.05898312
35	CAMK1	1.04774662
36	ADRBK1	1.04067322
37	CAMK1G	1.02521396
38	TIE1	0.99621721
39	MAPKAPK3	0.97381376
40	BTK	0.92679867
41	BUB1	0.92473110
42	MUSK	0.88909034
43	EIF2AK1	0.88699838
44	TNIK	0.88319094
45	NLK	0.87598899
46	PRKCQ	0.87331585
47	PRKCG	0.86146493
48	PIK3CA	0.82901348
49	IKBKB	0.79650418
50	DAPK2	0.79634782
51	RPS6KA5	0.78422144
52	INSRR	0.76838919
53	MAP3K12	0.76420613
54	WNK1	0.74091147
55	CSNK2A2	0.73493722
56	MAP3K11	0.72744561
57	CDC7	0.71982776
58	DAPK3	0.70685396
59	SYK	0.70401701
60	RPS6KB2	0.67131959
61	PIM1	0.65963666
62	NEK1	0.62968248
63	MAP2K7	0.62856845
64	STK11	0.61771399
65	PRKCH	0.61709646
66	CASK	0.61696656
67	EPHB2	0.60551075
68	MARK3	0.58387306
69	PRKCI	0.58189387
70	RPS6KA6	0.57904016
71	AURKB	0.56226007
72	MAPK13	0.55571835
73	IKBKE	0.54848501
74	MAPKAPK5	0.54496163
75	CAMK4	0.54457816
76	TESK2	0.53657517
77	GRK6	0.52472894
78	OBSCN	0.52191666
79	LYN	0.51983776
80	PRKACA	0.51916284
81	CSNK1E	0.51688423
82	MAP3K4	0.49766786
83	TAOK3	0.49062265
84	MAPK15	0.47262116
85	PLK1	0.45633399
86	CSNK2A1	0.45600525
87	LCK	0.45100478
88	PRKCA	0.44895866
89	AURKA	0.43066060
90	FES	0.42147384
91	MAP2K2	0.38560985
92	RPS6KA1	0.36894752
93	PAK6	0.35181053
94	GRK7	0.35104402
95	CAMK2A	0.34858935
96	PRKCD	0.33824512
97	PIM2	0.33812972
98	CSNK1G2	0.32940297
99	SRPK1	0.32434433
100	IRAK4	0.29894437

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.98684041
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.14119509
3	Parkinsons disease_Homo sapiens_hsa05012	3.33163276
4	RNA polymerase_Homo sapiens_hsa03020	2.95718948
5	Proteasome_Homo sapiens_hsa03050	2.71723016
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.35888982
7	Huntingtons disease_Homo sapiens_hsa05016	2.33271578
8	Alzheimers disease_Homo sapiens_hsa05010	2.24347679
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.18900674
10	Protein export_Homo sapiens_hsa03060	2.14548830
11	One carbon pool by folate_Homo sapiens_hsa00670	2.08646405
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.04030289
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94847462
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.93363082
15	Sulfur relay system_Homo sapiens_hsa04122	1.78408424
16	Homologous recombination_Homo sapiens_hsa03440	1.69758820
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.60433788
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.59587165
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.59396167
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56216535
21	Phototransduction_Homo sapiens_hsa04744	1.53136002
22	RNA degradation_Homo sapiens_hsa03018	1.52069731
23	Asthma_Homo sapiens_hsa05310	1.51398353
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48922633
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.48812426
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42738576
27	Caffeine metabolism_Homo sapiens_hsa00232	1.41716366
28	Allograft rejection_Homo sapiens_hsa05330	1.41356649
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25817817
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.23626312
31	Regulation of autophagy_Homo sapiens_hsa04140	1.18081380
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.12445131
33	Basal transcription factors_Homo sapiens_hsa03022	1.11540758
34	Purine metabolism_Homo sapiens_hsa00230	1.10463459
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09722796
36	Butanoate metabolism_Homo sapiens_hsa00650	1.00759704
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.00731738
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00522420
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97306065
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.97072895
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94615956
42	Propanoate metabolism_Homo sapiens_hsa00640	0.94141058
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.93898718
44	Mismatch repair_Homo sapiens_hsa03430	0.93844110
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92877848
46	Nicotine addiction_Homo sapiens_hsa05033	0.87697425
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.86412411
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.85719337
49	Base excision repair_Homo sapiens_hsa03410	0.84079001
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82460937
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82443013
52	Peroxisome_Homo sapiens_hsa04146	0.81217655
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81117196
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.77005549
55	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76247217
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.74633427
57	Metabolic pathways_Homo sapiens_hsa01100	0.72502571
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.71916813
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.71903211
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71631825
61	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69751286
62	Folate biosynthesis_Homo sapiens_hsa00790	0.67804758
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.67520432
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.65904517
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65209391
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64951467
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64037186
68	Sulfur metabolism_Homo sapiens_hsa00920	0.63975245
69	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63192922
70	RNA transport_Homo sapiens_hsa03013	0.56208398
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54135717
72	Spliceosome_Homo sapiens_hsa03040	0.53909959
73	DNA replication_Homo sapiens_hsa03030	0.53725505
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51493127
75	Retinol metabolism_Homo sapiens_hsa00830	0.51380895
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51108417
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49559606
78	Taste transduction_Homo sapiens_hsa04742	0.49369294
79	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.48797943
80	Morphine addiction_Homo sapiens_hsa05032	0.47874503
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46310886
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.45787011
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42584906
84	Olfactory transduction_Homo sapiens_hsa04740	0.42332986
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39020042
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.38889453
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37508271
88	Insulin secretion_Homo sapiens_hsa04911	0.34272303
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32452533
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32198580
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30772652
92	Antigen processing and presentation_Homo sapiens_hsa04612	0.27921345
93	Fatty acid degradation_Homo sapiens_hsa00071	0.27403450
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27085092
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.26802597
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.26093392
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24789976
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24214942
99	Mineral absorption_Homo sapiens_hsa04978	0.22851315
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22735725

RPL12P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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