ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	9.07308526
2	translational termination (GO:0006415)	8.72070322
3	maturation of SSU-rRNA (GO:0030490)	8.18026032
4	ribosomal small subunit assembly (GO:0000028)	8.07413584
5	ribosomal small subunit biogenesis (GO:0042274)	8.02198690
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.50099899
7	cotranslational protein targeting to membrane (GO:0006613)	7.42207645
8	protein targeting to ER (GO:0045047)	7.38435466
9	translational elongation (GO:0006414)	7.31383410
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.11422304
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	7.05549181
12	protein localization to endoplasmic reticulum (GO:0070972)	6.98779223
13	ribosomal large subunit biogenesis (GO:0042273)	6.87449164
14	cellular protein complex disassembly (GO:0043624)	6.63936971
15	viral life cycle (GO:0019058)	6.60751999
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.49558910
17	translational initiation (GO:0006413)	6.17138679
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.00863528
19	ATP synthesis coupled proton transport (GO:0015986)	6.00863528
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.89193335
21	protein complex disassembly (GO:0043241)	5.58622167
22	chaperone-mediated protein transport (GO:0072321)	5.35336921
23	macromolecular complex disassembly (GO:0032984)	5.24963769
24	translation (GO:0006412)	5.06585617
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.05945347
26	protein targeting to membrane (GO:0006612)	5.01315565
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.84563664
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.84563664
29	NADH dehydrogenase complex assembly (GO:0010257)	4.84563664
30	respiratory electron transport chain (GO:0022904)	4.78302363
31	electron transport chain (GO:0022900)	4.72236922
32	protein complex biogenesis (GO:0070271)	4.59343783
33	regulation of gene silencing by RNA (GO:0060966)	4.54859519
34	regulation of posttranscriptional gene silencing (GO:0060147)	4.54859519
35	regulation of gene silencing by miRNA (GO:0060964)	4.54859519
36	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.54001492
37	water-soluble vitamin biosynthetic process (GO:0042364)	4.48298374
38	ribonucleoprotein complex biogenesis (GO:0022613)	4.40059012
39	mRNA catabolic process (GO:0006402)	4.31373740
40	mitochondrial respiratory chain complex assembly (GO:0033108)	4.18652408
41	cellular component biogenesis (GO:0044085)	4.16091359
42	RNA catabolic process (GO:0006401)	3.95250190
43	inner mitochondrial membrane organization (GO:0007007)	3.87342694
44	intracellular protein transmembrane import (GO:0044743)	3.80706472
45	protein neddylation (GO:0045116)	3.65011254
46	negative regulation of gene silencing (GO:0060969)	3.63081452
47	GTP biosynthetic process (GO:0006183)	3.62629383
48	protein targeting (GO:0006605)	3.53367581
49	rRNA processing (GO:0006364)	3.49841427
50	establishment of protein localization to membrane (GO:0090150)	3.49098206
51	hydrogen ion transmembrane transport (GO:1902600)	3.48903252
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47199961
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47199961
54	rRNA metabolic process (GO:0016072)	3.44321452
55	nephron epithelium morphogenesis (GO:0072088)	3.41995229
56	nephron tubule morphogenesis (GO:0072078)	3.41995229
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.36907777
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.35514042
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30713766
60	establishment of protein localization to organelle (GO:0072594)	3.30406775
61	ATP biosynthetic process (GO:0006754)	3.28785164
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18634809
63	termination of RNA polymerase III transcription (GO:0006386)	3.18634809
64	UTP biosynthetic process (GO:0006228)	3.13898617
65	pattern specification involved in kidney development (GO:0061004)	3.11158962
66	intracellular protein transmembrane transport (GO:0065002)	3.09509864
67	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.01158716
68	proton transport (GO:0015992)	2.97194317
69	UTP metabolic process (GO:0046051)	2.92466197
70	protein targeting to mitochondrion (GO:0006626)	2.91578721
71	hydrogen transport (GO:0006818)	2.88918887
72	establishment of protein localization to mitochondrion (GO:0072655)	2.86806806
73	protein-cofactor linkage (GO:0018065)	2.85771903
74	nonmotile primary cilium assembly (GO:0035058)	2.85672310
75	behavioral response to nicotine (GO:0035095)	2.84959522
76	DNA deamination (GO:0045006)	2.81365687
77	protein localization to mitochondrion (GO:0070585)	2.78767107
78	pseudouridine synthesis (GO:0001522)	2.78553136
79	protein localization to membrane (GO:0072657)	2.77975553
80	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.77586459
81	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.77357110
82	centriole replication (GO:0007099)	2.76114675
83	CTP metabolic process (GO:0046036)	2.73054261
84	CTP biosynthetic process (GO:0006241)	2.73054261
85	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.72218194
86	tRNA processing (GO:0008033)	2.71880075
87	peptidyl-histidine modification (GO:0018202)	2.71684374
88	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.68425452
89	respiratory chain complex IV assembly (GO:0008535)	2.68265818
90	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.67748770
91	nucleoside triphosphate biosynthetic process (GO:0009142)	2.67562094
92	cytochrome complex assembly (GO:0017004)	2.65200359
93	aldehyde catabolic process (GO:0046185)	2.65085332
94	auditory receptor cell differentiation (GO:0042491)	2.64806514
95	ncRNA processing (GO:0034470)	2.64118579
96	formation of translation preinitiation complex (GO:0001731)	2.63824044
97	spliceosomal complex assembly (GO:0000245)	2.57408576
98	regulation of mitochondrial translation (GO:0070129)	2.56448405
99	platelet dense granule organization (GO:0060155)	2.54298254
100	mechanoreceptor differentiation (GO:0042490)	2.54030958

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.47717106
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.12011919
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.80747039
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.29989714
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.03605227
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.69694236
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.33997591
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.20579183
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.17177885
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.14851324
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.03384380
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.62302707
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.52642913
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.46339226
15	TTF2_22483619_ChIP-Seq_HELA_Human	2.43557910
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.39241624
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.27587596
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.21502210
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.18245760
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.16851126
21	XRN2_22483619_ChIP-Seq_HELA_Human	2.16559316
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.14786206
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08901239
24	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99494009
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98067484
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.96310555
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84218922
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76467419
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75929648
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.74500755
31	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.74273380
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.57379020
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50585610
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50472133
35	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.50257408
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.47742991
37	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.46308478
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.43366752
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41784238
40	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.38821343
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.32990525
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31681273
43	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31491585
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29777216
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29777216
46	EWS_26573619_Chip-Seq_HEK293_Human	1.29699175
47	VDR_22108803_ChIP-Seq_LS180_Human	1.26379057
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.21896061
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.18647397
50	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.18555110
51	P53_21459846_ChIP-Seq_SAOS-2_Human	1.17760538
52	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.16964553
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16672237
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16623102
55	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.16475971
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.11196504
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.10858764
58	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.10671651
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09607207
60	ERA_21632823_ChIP-Seq_H3396_Human	1.09313007
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07721840
62	FUS_26573619_Chip-Seq_HEK293_Human	1.06667284
63	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.04016306
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03683598
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03543151
66	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.03443603
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01761512
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01153735
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01136836
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99125623
71	AR_20517297_ChIP-Seq_VCAP_Human	0.99061324
72	MYC_19829295_ChIP-Seq_ESCs_Human	0.97940298
73	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97363574
74	ERG_20517297_ChIP-Seq_VCAP_Human	0.96339545
75	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.96102202
76	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.95756406
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.93091127
78	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.93043332
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92442350
80	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.91594011
81	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.90654337
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.90507357
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90504136
84	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.90311713
85	EZH2_22144423_ChIP-Seq_EOC_Human	0.89666322
86	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.89403999
87	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89272999
88	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88931007
89	KDM5A_27292631_Chip-Seq_BREAST_Human	0.88906932
90	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.85927373
91	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.84732423
92	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.83907068
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.83459517
94	NCOR_22424771_ChIP-Seq_293T_Human	0.82540640
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.78999142
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.78999142
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.78907869
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.78905007
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.78774156
100	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.78437135

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.51757214
2	MP0003787_abnormal_imprinting	3.88163502
3	MP0004885_abnormal_endolymph	3.86241810
4	MP0004043_abnormal_pH_regulation	3.40030617
5	MP0006292_abnormal_olfactory_placode	3.12264271
6	MP0002837_dystrophic_cardiac_calcinosis	3.01953700
7	MP0002234_abnormal_pharynx_morphology	2.97109403
8	MP0003123_paternal_imprinting	2.89246149
9	MP0004142_abnormal_muscle_tone	2.31141258
10	MP0003646_muscle_fatigue	2.27765408
11	MP0008877_abnormal_DNA_methylation	2.23178282
12	MP0002938_white_spotting	1.96220382
13	MP0008789_abnormal_olfactory_epithelium	1.92662092
14	MP0003878_abnormal_ear_physiology	1.90219319
15	MP0005377_hearing/vestibular/ear_phenot	1.90219319
16	MP0004147_increased_porphyrin_level	1.87926490
17	MP0001984_abnormal_olfaction	1.86888732
18	MP0003121_genomic_imprinting	1.82645060
19	MP0002163_abnormal_gland_morphology	1.78415417
20	MP0009053_abnormal_anal_canal	1.68893572
21	MP0002095_abnormal_skin_pigmentation	1.68738422
22	MP0003186_abnormal_redox_activity	1.61249576
23	MP0003011_delayed_dark_adaptation	1.59927200
24	MP0001293_anophthalmia	1.59908186
25	MP0003283_abnormal_digestive_organ	1.58944709
26	MP0000427_abnormal_hair_cycle	1.58761986
27	MP0002102_abnormal_ear_morphology	1.57244359
28	MP0002653_abnormal_ependyma_morphology	1.55348610
29	MP0003122_maternal_imprinting	1.47950820
30	MP0000372_irregular_coat_pigmentation	1.41786867
31	MP0002736_abnormal_nociception_after	1.39497204
32	MP0002796_impaired_skin_barrier	1.35560803
33	MP0002098_abnormal_vibrissa_morphology	1.33477586
34	MP0001485_abnormal_pinna_reflex	1.32672994
35	MP0010234_abnormal_vibrissa_follicle	1.31877245
36	MP0005501_abnormal_skin_physiology	1.30356188
37	MP0005174_abnormal_tail_pigmentation	1.29966457
38	MP0008872_abnormal_physiological_respon	1.26174620
39	MP0004742_abnormal_vestibular_system	1.25150193
40	MP0010030_abnormal_orbit_morphology	1.23373776
41	MP0006072_abnormal_retinal_apoptosis	1.20344333
42	MP0005499_abnormal_olfactory_system	1.19541504
43	MP0005394_taste/olfaction_phenotype	1.19541504
44	MP0001905_abnormal_dopamine_level	1.19026855
45	MP0002233_abnormal_nose_morphology	1.19003740
46	MP0003786_premature_aging	1.15937399
47	MP0005389_reproductive_system_phenotype	1.13710511
48	MP0001919_abnormal_reproductive_system	1.12033672
49	MP0001968_abnormal_touch/_nociception	1.11621155
50	MP0002277_abnormal_respiratory_mucosa	1.10965622
51	MP0005379_endocrine/exocrine_gland_phen	1.10034666
52	MP0006036_abnormal_mitochondrial_physio	1.09488455
53	MP0003693_abnormal_embryo_hatching	1.07056422
54	MP0002160_abnormal_reproductive_system	1.06483483
55	MP0005551_abnormal_eye_electrophysiolog	1.05108683
56	MP0008775_abnormal_heart_ventricle	1.05029399
57	MP0000026_abnormal_inner_ear	1.01401384
58	MP0004145_abnormal_muscle_electrophysio	1.01383044
59	MP0004133_heterotaxia	1.00664423
60	MP0003718_maternal_effect	0.99756482
61	MP0000049_abnormal_middle_ear	0.99742856
62	MP0000647_abnormal_sebaceous_gland	0.98644794
63	MP0004185_abnormal_adipocyte_glucose	0.96958131
64	MP0010678_abnormal_skin_adnexa	0.92590725
65	MP0000569_abnormal_digit_pigmentation	0.91741653
66	MP0002210_abnormal_sex_determination	0.88376996
67	MP0002272_abnormal_nervous_system	0.86869684
68	MP0003938_abnormal_ear_development	0.84759036
69	MP0000579_abnormal_nail_morphology	0.84646965
70	MP0001986_abnormal_taste_sensitivity	0.82406522
71	MP0001502_abnormal_circadian_rhythm	0.79564172
72	MP0001346_abnormal_lacrimal_gland	0.78074092
73	MP0001529_abnormal_vocalization	0.76636798
74	MP0005646_abnormal_pituitary_gland	0.76382289
75	MP0000383_abnormal_hair_follicle	0.75832666
76	MP0005195_abnormal_posterior_eye	0.73163120
77	MP0001764_abnormal_homeostasis	0.72109710
78	MP0005253_abnormal_eye_physiology	0.71546305
79	MP0000230_abnormal_systemic_arterial	0.70979162
80	MP0009046_muscle_twitch	0.66379324
81	MP0002138_abnormal_hepatobiliary_system	0.65635070
82	MP0003755_abnormal_palate_morphology	0.65570346
83	MP0008058_abnormal_DNA_repair	0.65219065
84	MP0000653_abnormal_sex_gland	0.64948839
85	MP0003936_abnormal_reproductive_system	0.64342117
86	MP0008875_abnormal_xenobiotic_pharmacok	0.63519465
87	MP0010771_integument_phenotype	0.63183771
88	MP0001286_abnormal_eye_development	0.63175846
89	MP0005636_abnormal_mineral_homeostasis	0.62979299
90	MP0005075_abnormal_melanosome_morpholog	0.62538398
91	MP0005391_vision/eye_phenotype	0.62162507
92	MP0004019_abnormal_vitamin_homeostasis	0.61731010
93	MP0002184_abnormal_innervation	0.61444203
94	MP0001663_abnormal_digestive_system	0.61343626
95	MP0005275_abnormal_skin_tensile	0.61281707
96	MP0002752_abnormal_somatic_nervous	0.61233416
97	MP0009764_decreased_sensitivity_to	0.60236583
98	MP0002111_abnormal_tail_morphology	0.59826359
99	MP0009745_abnormal_behavioral_response	0.59794983
100	MP0003315_abnormal_perineum_morphology	0.57785805

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nonprogressive disorder (HP:0003680)	8.29464054
2	Reticulocytopenia (HP:0001896)	6.45647126
3	Abnormality of cells of the erythroid lineage (HP:0012130)	5.18962524
4	Acute necrotizing encephalopathy (HP:0006965)	5.03420867
5	Abnormal number of erythroid precursors (HP:0012131)	4.54535852
6	Acute encephalopathy (HP:0006846)	4.43006213
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.33722869
8	Progressive macrocephaly (HP:0004481)	4.16285623
9	Macrocytic anemia (HP:0001972)	4.04111456
10	Mitochondrial inheritance (HP:0001427)	4.00619312
11	Increased CSF lactate (HP:0002490)	3.69001510
12	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.43831049
13	Abnormality of midbrain morphology (HP:0002418)	3.34753232
14	Molar tooth sign on MRI (HP:0002419)	3.34753232
15	Fragile nails (HP:0001808)	3.31869909
16	Pallor (HP:0000980)	3.27148105
17	Cerebral edema (HP:0002181)	3.24180180
18	Increased hepatocellular lipid droplets (HP:0006565)	3.23916579
19	Pancreatic cysts (HP:0001737)	3.21328341
20	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.18243898
21	Hepatic necrosis (HP:0002605)	3.16323528
22	Woolly hair (HP:0002224)	3.10903189
23	Congenital, generalized hypertrichosis (HP:0004540)	2.94332749
24	Oral leukoplakia (HP:0002745)	2.92327462
25	Pancreatic fibrosis (HP:0100732)	2.90513945
26	Hepatocellular necrosis (HP:0001404)	2.86368219
27	Erythroderma (HP:0001019)	2.75965320
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.73270652
29	Lipid accumulation in hepatocytes (HP:0006561)	2.70460447
30	Testicular atrophy (HP:0000029)	2.67854318
31	Chronic hepatic failure (HP:0100626)	2.67768795
32	Increased serum lactate (HP:0002151)	2.64828542
33	Renal Fanconi syndrome (HP:0001994)	2.64781274
34	Renal cortical cysts (HP:0000803)	2.54956895
35	Corneal dystrophy (HP:0001131)	2.53807575
36	Absent thumb (HP:0009777)	2.53191535
37	3-Methylglutaconic aciduria (HP:0003535)	2.51507264
38	Abnormality of the renal cortex (HP:0011035)	2.48314546
39	Medial flaring of the eyebrow (HP:0010747)	2.44238815
40	Nephronophthisis (HP:0000090)	2.43917274
41	Microvesicular hepatic steatosis (HP:0001414)	2.43740796
42	Amniotic constriction ring (HP:0009775)	2.41701869
43	Abnormality of placental membranes (HP:0011409)	2.41701869
44	Exercise intolerance (HP:0003546)	2.39011286
45	Lactic acidosis (HP:0003128)	2.38530398
46	Congenital ichthyosiform erythroderma (HP:0007431)	2.38276180
47	Optic disc pallor (HP:0000543)	2.36755101
48	Hyperglycinemia (HP:0002154)	2.36728574
49	Type II lissencephaly (HP:0007260)	2.30602619
50	Abnormal hemoglobin (HP:0011902)	2.29768737
51	Parakeratosis (HP:0001036)	2.21410533
52	Progressive muscle weakness (HP:0003323)	2.19249281
53	Respiratory failure (HP:0002878)	2.17755492
54	Abnormality of urine glucose concentration (HP:0011016)	2.17126755
55	Glycosuria (HP:0003076)	2.17126755
56	Abnormality of DNA repair (HP:0003254)	2.16159456
57	Exertional dyspnea (HP:0002875)	2.12140046
58	Leukodystrophy (HP:0002415)	2.10642749
59	Abnormality of small intestinal villus morphology (HP:0011472)	2.09628664
60	Villous atrophy (HP:0011473)	2.09628664
61	Generalized aminoaciduria (HP:0002909)	2.09405957
62	Median cleft lip (HP:0000161)	2.06966345
63	Abnormality of the renal medulla (HP:0100957)	2.04720652
64	Hypoplasia of the radius (HP:0002984)	2.03878880
65	Squamous cell carcinoma (HP:0002860)	2.03628885
66	Cystic liver disease (HP:0006706)	2.02866942
67	True hermaphroditism (HP:0010459)	2.01071544
68	Respiratory difficulties (HP:0002880)	2.00364697
69	Depressed nasal ridge (HP:0000457)	1.99005450
70	Increased intramyocellular lipid droplets (HP:0012240)	1.97947718
71	Cleft eyelid (HP:0000625)	1.96531549
72	Colon cancer (HP:0003003)	1.93608946
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.93359487
74	Type 2 muscle fiber atrophy (HP:0003554)	1.92556535
75	Abnormality of renal resorption (HP:0011038)	1.88270814
76	Abnormal biliary tract physiology (HP:0012439)	1.84371744
77	Bile duct proliferation (HP:0001408)	1.84371744
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.84101314
79	Hypoplasia of the pons (HP:0012110)	1.83929838
80	Rib fusion (HP:0000902)	1.82885571
81	Lethargy (HP:0001254)	1.82554477
82	Septo-optic dysplasia (HP:0100842)	1.82364253
83	Abnormality of the pons (HP:0007361)	1.81474705
84	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.79518563
85	Abnormality of reticulocytes (HP:0004312)	1.77047864
86	Cerebellar dysplasia (HP:0007033)	1.74056639
87	Congenital primary aphakia (HP:0007707)	1.72890849
88	Forearm undergrowth (HP:0009821)	1.72636817
89	Elevated erythrocyte sedimentation rate (HP:0003565)	1.69684572
90	Hypoplasia of the ulna (HP:0003022)	1.69460672
91	Large for gestational age (HP:0001520)	1.68987868
92	Alopecia of scalp (HP:0002293)	1.68264098
93	Brittle hair (HP:0002299)	1.67614692
94	Sclerocornea (HP:0000647)	1.65975333
95	Furrowed tongue (HP:0000221)	1.65253298
96	Pendular nystagmus (HP:0012043)	1.64034225
97	Gait imbalance (HP:0002141)	1.63221974
98	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.60659562
99	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.60659562
100	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.60492907

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.14325836
2	TLK1	4.48123232
3	CDK19	3.77214995
4	EPHB2	3.08310808
5	WNK4	2.58069504
6	PINK1	2.32559650
7	NUAK1	2.29168678
8	VRK2	2.23863465
9	WNK1	2.18805835
10	TAOK3	2.14998348
11	MAP4K2	2.14709137
12	BUB1	2.00434648
13	GRK1	1.98788899
14	ZAK	1.90838022
15	NME1	1.74850880
16	PASK	1.71648660
17	PLK4	1.63658271
18	BCKDK	1.56174859
19	ADRBK2	1.48136155
20	FRK	1.37490448
21	ILK	1.36112240
22	PIK3CA	1.34987928
23	VRK1	1.34936878
24	NEK2	1.30488826
25	TXK	1.29454091
26	GRK7	1.27648150
27	TEC	1.26974976
28	NME2	1.23686132
29	PHKG1	1.21781209
30	PHKG2	1.21781209
31	DAPK3	1.20926543
32	CDC7	1.12692107
33	TIE1	1.11030299
34	PRKCG	1.10351176
35	LRRK2	1.05052446
36	CAMKK2	1.04841958
37	GRK5	1.00836433
38	ABL2	0.97100966
39	MST4	0.94759254
40	TAF1	0.94009914
41	ADRBK1	0.93802424
42	CDK8	0.89196446
43	CAMK1D	0.88709207
44	DYRK2	0.88585971
45	DMPK	0.87861991
46	TRIM28	0.84182056
47	AURKA	0.84012762
48	PRKCH	0.81778422
49	WNK3	0.81680422
50	AURKB	0.80670551
51	MAP2K6	0.79208842
52	DAPK2	0.78544862
53	STK24	0.78314826
54	PLK3	0.75135110
55	CSNK2A2	0.75048347
56	NEK1	0.73842654
57	CHEK2	0.69462878
58	PBK	0.69403657
59	MAP4K1	0.68191879
60	STK39	0.64898203
61	CAMK1	0.63877440
62	OXSR1	0.63836349
63	TGFBR2	0.63751908
64	CAMK1G	0.63577584
65	RPS6KB2	0.62986569
66	ITK	0.61559744
67	FLT3	0.58910292
68	GRK6	0.58896922
69	CSNK2A1	0.58529355
70	MOS	0.58507457
71	BTK	0.56862457
72	PLK1	0.55975504
73	CSNK1E	0.54822599
74	INSRR	0.54213403
75	MKNK1	0.53390874
76	SRPK1	0.53367009
77	EPHA4	0.45860560
78	RPS6KA5	0.45479943
79	IKBKB	0.44518029
80	BMPR1B	0.44097859
81	ATR	0.44060589
82	RPS6KA6	0.41551927
83	MKNK2	0.40630244
84	LIMK1	0.40163001
85	PRKACA	0.39767035
86	STK3	0.39498997
87	PRKD2	0.37486761
88	EIF2AK2	0.37151027
89	TNK2	0.36634203
90	TTK	0.35510885
91	PRKCD	0.35489969
92	PIK3CG	0.34484873
93	PRKCQ	0.33464335
94	MUSK	0.32688994
95	PRKCI	0.31370210
96	STK11	0.31343368
97	PRKCA	0.28943877
98	IRAK2	0.28889950
99	TGFBR1	0.27909980
100	PRKG1	0.27658599

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.39991250
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.78748076
3	Parkinsons disease_Homo sapiens_hsa05012	3.69196308
4	RNA polymerase_Homo sapiens_hsa03020	3.01067490
5	Huntingtons disease_Homo sapiens_hsa05016	2.71362692
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.61314078
7	Alzheimers disease_Homo sapiens_hsa05010	2.56223930
8	Proteasome_Homo sapiens_hsa03050	2.54270829
9	Asthma_Homo sapiens_hsa05310	2.16337472
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.14846462
11	Protein export_Homo sapiens_hsa03060	2.09778778
12	Homologous recombination_Homo sapiens_hsa03440	2.00432843
13	Mismatch repair_Homo sapiens_hsa03430	1.91769240
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89860737
15	Basal transcription factors_Homo sapiens_hsa03022	1.89437696
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65750706
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.64692960
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64137785
19	DNA replication_Homo sapiens_hsa03030	1.54053919
20	RNA degradation_Homo sapiens_hsa03018	1.48859681
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.42254556
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41525289
23	Base excision repair_Homo sapiens_hsa03410	1.38768774
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.34935586
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32376076
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.32154802
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31752058
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21205063
29	One carbon pool by folate_Homo sapiens_hsa00670	1.19743985
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18787069
31	Sulfur relay system_Homo sapiens_hsa04122	1.18144263
32	Allograft rejection_Homo sapiens_hsa05330	1.16311722
33	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.13784129
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10399706
35	Phototransduction_Homo sapiens_hsa04744	1.06125447
36	Purine metabolism_Homo sapiens_hsa00230	1.05982524
37	RNA transport_Homo sapiens_hsa03013	1.02880953
38	Peroxisome_Homo sapiens_hsa04146	1.00436977
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.97037040
40	Arginine biosynthesis_Homo sapiens_hsa00220	0.96943330
41	Nitrogen metabolism_Homo sapiens_hsa00910	0.94999133
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93365438
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.91662775
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90181090
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89625505
46	Spliceosome_Homo sapiens_hsa03040	0.85066338
47	p53 signaling pathway_Homo sapiens_hsa04115	0.79536494
48	Metabolic pathways_Homo sapiens_hsa01100	0.78877928
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.78007810
50	Glutathione metabolism_Homo sapiens_hsa00480	0.74159427
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.69616268
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67801743
53	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66123072
54	Graft-versus-host disease_Homo sapiens_hsa05332	0.65712874
55	Basal cell carcinoma_Homo sapiens_hsa05217	0.61842986
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60445671
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.60139137
58	Propanoate metabolism_Homo sapiens_hsa00640	0.57337666
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56248667
60	Regulation of autophagy_Homo sapiens_hsa04140	0.55641570
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.54997208
62	Retinol metabolism_Homo sapiens_hsa00830	0.54027330
63	Caffeine metabolism_Homo sapiens_hsa00232	0.51854144
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.47777109
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46234815
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45916671
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45334133
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.44789772
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.44117812
70	Butanoate metabolism_Homo sapiens_hsa00650	0.42532263
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39346727
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.38740065
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38608191
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37797857
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.35990407
76	Olfactory transduction_Homo sapiens_hsa04740	0.35868130
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33581787
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31420770
79	Phenylalanine metabolism_Homo sapiens_hsa00360	0.31350620
80	Folate biosynthesis_Homo sapiens_hsa00790	0.29180135
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28426504
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27194968
83	Mineral absorption_Homo sapiens_hsa04978	0.25353394
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24689379
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23639084
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.22680043
87	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.22317327
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21955409
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.19953068
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.19815261
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.19507525
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.19485237
93	Histidine metabolism_Homo sapiens_hsa00340	0.18542848
94	Fatty acid degradation_Homo sapiens_hsa00071	0.15887524
95	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.13139036
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.12920215
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.12570962
98	Galactose metabolism_Homo sapiens_hsa00052	0.12121462
99	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.11499942
100	Serotonergic synapse_Homo sapiens_hsa04726	0.09514277

RPL12P35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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