RPL12P37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.97536193
2viral transcription (GO:0019083)5.51106018
3DNA deamination (GO:0045006)5.48924524
4translational termination (GO:0006415)5.37152717
5maturation of SSU-rRNA (GO:0030490)5.30258543
6ribosomal small subunit biogenesis (GO:0042274)5.29205007
7behavioral response to nicotine (GO:0035095)5.28823671
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22548189
9ATP synthesis coupled proton transport (GO:0015986)5.22548189
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.03694818
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.01598840
12protein complex biogenesis (GO:0070271)4.77622120
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.70958424
14cotranslational protein targeting to membrane (GO:0006613)4.64578457
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61264779
16protein targeting to ER (GO:0045047)4.60651329
17translational elongation (GO:0006414)4.58532048
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56001155
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.56001155
20NADH dehydrogenase complex assembly (GO:0010257)4.56001155
21mitochondrial respiratory chain complex assembly (GO:0033108)4.42762523
22cytidine metabolic process (GO:0046087)4.39631486
23cytidine catabolic process (GO:0006216)4.39631486
24cytidine deamination (GO:0009972)4.39631486
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.39597488
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.38658741
27protein localization to endoplasmic reticulum (GO:0070972)4.35934760
28transcription elongation from RNA polymerase III promoter (GO:0006385)4.32187132
29termination of RNA polymerase III transcription (GO:0006386)4.32187132
30protein neddylation (GO:0045116)4.24458739
31respiratory electron transport chain (GO:0022904)4.19774849
32electron transport chain (GO:0022900)4.19142080
33viral life cycle (GO:0019058)4.07292659
34pyrimidine ribonucleoside catabolic process (GO:0046133)4.00162918
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.00103291
36water-soluble vitamin biosynthetic process (GO:0042364)3.96324253
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94535867
38nonmotile primary cilium assembly (GO:0035058)3.92782185
39cellular protein complex disassembly (GO:0043624)3.91438001
40proteasome assembly (GO:0043248)3.81156056
41chaperone-mediated protein transport (GO:0072321)3.76166788
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.65970273
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.65970273
44translational initiation (GO:0006413)3.57229897
45translation (GO:0006412)3.53800778
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38127862
47rRNA modification (GO:0000154)3.37905383
48cytochrome complex assembly (GO:0017004)3.36825292
49respiratory chain complex IV assembly (GO:0008535)3.36652677
50ribosomal large subunit biogenesis (GO:0042273)3.33189205
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30541936
52cellular component biogenesis (GO:0044085)3.29779671
53hydrogen ion transmembrane transport (GO:1902600)3.25446178
54positive regulation of defense response to virus by host (GO:0002230)3.18900470
55protein complex disassembly (GO:0043241)3.12271499
56negative regulation of cAMP-mediated signaling (GO:0043951)3.11314477
57adaptation of signaling pathway (GO:0023058)3.10631222
58rRNA processing (GO:0006364)3.06729086
59platelet dense granule organization (GO:0060155)3.04068903
60ATP biosynthetic process (GO:0006754)3.02714018
61negative regulation of response to food (GO:0032096)3.02601735
62negative regulation of appetite (GO:0032099)3.02601735
63DNA strand renaturation (GO:0000733)3.02135306
64tongue development (GO:0043586)3.02037448
65protein targeting to membrane (GO:0006612)3.01937084
66ribonucleoprotein complex biogenesis (GO:0022613)3.01342506
67rRNA metabolic process (GO:0016072)2.99429239
68rRNA methylation (GO:0031167)2.98404868
69proton transport (GO:0015992)2.96691947
70regulation of mitochondrial translation (GO:0070129)2.96553565
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95374607
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.94906454
73nuclear-transcribed mRNA catabolic process (GO:0000956)2.94614140
74macromolecular complex disassembly (GO:0032984)2.92788898
75mannosylation (GO:0097502)2.90492217
76hydrogen transport (GO:0006818)2.88186646
77transcription from RNA polymerase III promoter (GO:0006383)2.85074771
78transmission of nerve impulse (GO:0019226)2.83537983
79peptidyl-histidine modification (GO:0018202)2.82737538
80positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.81890256
81mRNA catabolic process (GO:0006402)2.78679172
82pyrimidine ribonucleoside metabolic process (GO:0046131)2.74515861
83synaptic transmission, cholinergic (GO:0007271)2.74074185
84GTP biosynthetic process (GO:0006183)2.72133141
85iron-sulfur cluster assembly (GO:0016226)2.68987874
86metallo-sulfur cluster assembly (GO:0031163)2.68987874
87positive regulation of T cell apoptotic process (GO:0070234)2.68596420
88regulation of action potential (GO:0098900)2.68437179
89detection of mechanical stimulus involved in sensory perception (GO:0050974)2.68145832
90somite development (GO:0061053)2.67627278
91detection of light stimulus involved in visual perception (GO:0050908)2.65455149
92detection of light stimulus involved in sensory perception (GO:0050962)2.65455149
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65147114
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.62996910
95pseudouridine synthesis (GO:0001522)2.62242224
96regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.59829544
97positive regulation of fatty acid transport (GO:2000193)2.59006771
98fucose catabolic process (GO:0019317)2.54713544
99L-fucose metabolic process (GO:0042354)2.54713544
100L-fucose catabolic process (GO:0042355)2.54713544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06226253
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.09824670
3HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.37378627
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.27007853
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26697184
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14392619
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.91970372
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82318786
9ZNF274_21170338_ChIP-Seq_K562_Hela2.81860101
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71260445
11VDR_22108803_ChIP-Seq_LS180_Human2.44967753
12VDR_23849224_ChIP-Seq_CD4+_Human2.30510686
13ELK1_19687146_ChIP-ChIP_HELA_Human2.19881897
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.17444329
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08573778
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99939152
17MYC_18940864_ChIP-ChIP_HL60_Human1.92702866
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91652623
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87175144
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.82961328
21TP53_22573176_ChIP-Seq_HFKS_Human1.80226193
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.79582948
23EWS_26573619_Chip-Seq_HEK293_Human1.78459799
24FOXP3_21729870_ChIP-Seq_TREG_Human1.73778954
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73688799
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65740333
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54779834
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53693470
29TTF2_22483619_ChIP-Seq_HELA_Human1.43262807
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41331681
31NCOR_22424771_ChIP-Seq_293T_Human1.41208602
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38878183
33GATA3_21878914_ChIP-Seq_MCF-7_Human1.37591303
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.34203934
35ERA_21632823_ChIP-Seq_H3396_Human1.33471530
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33171332
37NANOG_20526341_ChIP-Seq_ESCs_Human1.32227233
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31275952
39FUS_26573619_Chip-Seq_HEK293_Human1.29536401
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29025098
41MYC_19829295_ChIP-Seq_ESCs_Human1.27586986
42P53_21459846_ChIP-Seq_SAOS-2_Human1.27438928
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26291710
44XRN2_22483619_ChIP-Seq_HELA_Human1.25377358
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24540443
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24364223
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.24364223
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24067087
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23364709
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.21436874
51SOX2_19829295_ChIP-Seq_ESCs_Human1.21340045
52NANOG_19829295_ChIP-Seq_ESCs_Human1.21340045
53IRF1_19129219_ChIP-ChIP_H3396_Human1.16675348
54GABP_19822575_ChIP-Seq_HepG2_Human1.15549609
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15489517
56FOXH1_21741376_ChIP-Seq_EPCs_Human1.11550796
57TAF2_19829295_ChIP-Seq_ESCs_Human1.11249280
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09332993
59BCL6_27268052_Chip-Seq_Bcells_Human1.07096551
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05499397
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05203700
62GBX2_23144817_ChIP-Seq_PC3_Human1.04382230
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.04271913
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03558635
65AR_20517297_ChIP-Seq_VCAP_Human1.03429335
66P300_19829295_ChIP-Seq_ESCs_Human1.03029810
67GATA1_22025678_ChIP-Seq_K562_Human1.01521518
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01326795
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00265276
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98877746
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97630462
72FOXH1_21741376_ChIP-Seq_ESCs_Human0.96455380
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96396919
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96147780
75ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96097046
76ER_23166858_ChIP-Seq_MCF-7_Human0.95841207
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95567548
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95490464
79HOXB7_26014856_ChIP-Seq_BT474_Human0.94263917
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93548818
81MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93463761
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92493317
83E2F1_20622854_ChIP-Seq_HELA_Human0.91198098
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90792960
85CTCF_20526341_ChIP-Seq_ESCs_Human0.89346204
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88799259
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88747774
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87645553
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86204822
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.85084834
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.84642045
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84226740
93OCT4_20526341_ChIP-Seq_ESCs_Human0.83852487
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.83726609
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83476682
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83470901
97CBP_20019798_ChIP-Seq_JUKART_Human0.83470901
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82350721
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82190003
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81901295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.79679067
2MP0006292_abnormal_olfactory_placode3.79425129
3MP0003136_yellow_coat_color3.71663193
4MP0008877_abnormal_DNA_methylation2.79146109
5MP0008789_abnormal_olfactory_epithelium2.67653450
6MP0001968_abnormal_touch/_nociception2.50882253
7MP0004147_increased_porphyrin_level2.41931685
8MP0001529_abnormal_vocalization2.33211395
9MP0001485_abnormal_pinna_reflex2.21664987
10MP0003878_abnormal_ear_physiology2.14072673
11MP0005377_hearing/vestibular/ear_phenot2.14072673
12MP0005551_abnormal_eye_electrophysiolog2.07434394
13MP0002653_abnormal_ependyma_morphology2.05546686
14MP0008875_abnormal_xenobiotic_pharmacok2.03519881
15MP0003646_muscle_fatigue1.99241415
16MP0001986_abnormal_taste_sensitivity1.99112141
17MP0004142_abnormal_muscle_tone1.97085995
18MP0002102_abnormal_ear_morphology1.89782333
19MP0005174_abnormal_tail_pigmentation1.87689097
20MP0005394_taste/olfaction_phenotype1.79891317
21MP0005499_abnormal_olfactory_system1.79891317
22MP0002277_abnormal_respiratory_mucosa1.75719707
23MP0002638_abnormal_pupillary_reflex1.73552592
24MP0002736_abnormal_nociception_after1.72731633
25MP0001984_abnormal_olfaction1.70090282
26MP0008872_abnormal_physiological_respon1.68361397
27MP0006072_abnormal_retinal_apoptosis1.68070717
28MP0006276_abnormal_autonomic_nervous1.66180259
29MP0002163_abnormal_gland_morphology1.61260303
30MP0005645_abnormal_hypothalamus_physiol1.60469351
31MP0001905_abnormal_dopamine_level1.58185247
32MP0003011_delayed_dark_adaptation1.58161099
33MP0003718_maternal_effect1.51699805
34MP0001293_anophthalmia1.51092637
35MP0002160_abnormal_reproductive_system1.50918043
36MP0008775_abnormal_heart_ventricle1.45895096
37MP0005671_abnormal_response_to1.43260689
38MP0005423_abnormal_somatic_nervous1.40614184
39MP0004742_abnormal_vestibular_system1.32890575
40MP0000427_abnormal_hair_cycle1.29896687
41MP0006035_abnormal_mitochondrial_morpho1.27490289
42MP0002272_abnormal_nervous_system1.27425032
43MP0002733_abnormal_thermal_nociception1.26360482
44MP0004145_abnormal_muscle_electrophysio1.25108548
45MP0005253_abnormal_eye_physiology1.22950669
46MP0009745_abnormal_behavioral_response1.21778063
47MP0003880_abnormal_central_pattern1.21433231
48MP0006036_abnormal_mitochondrial_physio1.19202524
49MP0002876_abnormal_thyroid_physiology1.16636247
50MP0002735_abnormal_chemical_nociception1.16274218
51MP0003786_premature_aging1.15518837
52MP0001970_abnormal_pain_threshold1.15115885
53MP0004885_abnormal_endolymph1.14848469
54MP0005195_abnormal_posterior_eye1.14151374
55MP0001501_abnormal_sleep_pattern1.11156726
56MP0005389_reproductive_system_phenotype1.08329520
57MP0002095_abnormal_skin_pigmentation1.07706559
58MP0004381_abnormal_hair_follicle1.07495912
59MP0001486_abnormal_startle_reflex1.05394012
60MP0001873_stomach_inflammation1.03533246
61MP0002837_dystrophic_cardiac_calcinosis1.03518604
62MP0002184_abnormal_innervation1.02816278
63MP0004019_abnormal_vitamin_homeostasis1.02805264
64MP0000569_abnormal_digit_pigmentation1.02760409
65MP0000230_abnormal_systemic_arterial1.02361621
66MP0003186_abnormal_redox_activity1.01127733
67MP0000685_abnormal_immune_system0.96634282
68MP0001963_abnormal_hearing_physiology0.96563693
69MP0002234_abnormal_pharynx_morphology0.93635737
70MP0000613_abnormal_salivary_gland0.92082370
71MP0002938_white_spotting0.90222751
72MP0000049_abnormal_middle_ear0.88226008
73MP0001790_abnormal_immune_system0.87529110
74MP0005387_immune_system_phenotype0.87529110
75MP0000026_abnormal_inner_ear0.86281314
76MP0003693_abnormal_embryo_hatching0.85705819
77MP0003787_abnormal_imprinting0.83752209
78MP0000566_synostosis0.83092360
79MP0005379_endocrine/exocrine_gland_phen0.81654051
80MP0002752_abnormal_somatic_nervous0.81165328
81MP0005332_abnormal_amino_acid0.81150918
82MP0002557_abnormal_social/conspecific_i0.80282394
83MP0000631_abnormal_neuroendocrine_gland0.79264552
84MP0004133_heterotaxia0.78015267
85MP0001853_heart_inflammation0.76845014
86MP0000372_irregular_coat_pigmentation0.75963410
87MP0001756_abnormal_urination0.75688567
88MP0001881_abnormal_mammary_gland0.75447674
89MP0002572_abnormal_emotion/affect_behav0.74969248
90MP0002210_abnormal_sex_determination0.73927440
91MP0005646_abnormal_pituitary_gland0.71923736
92MP0002138_abnormal_hepatobiliary_system0.71868729
93MP0001502_abnormal_circadian_rhythm0.69883682
94MP0003950_abnormal_plasma_membrane0.68081406
95MP0005410_abnormal_fertilization0.67906787
96MP0001764_abnormal_homeostasis0.64556363
97MP0005084_abnormal_gallbladder_morpholo0.64038963
98MP0001119_abnormal_female_reproductive0.63809329
99MP0001727_abnormal_embryo_implantation0.62333836
100MP0004215_abnormal_myocardial_fiber0.61737836

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.66437122
2Mitochondrial inheritance (HP:0001427)4.45179449
3Increased hepatocellular lipid droplets (HP:0006565)4.28362281
4Lipid accumulation in hepatocytes (HP:0006561)4.15744668
5Hepatocellular necrosis (HP:0001404)4.14240800
6Increased CSF lactate (HP:0002490)4.14054946
7Abnormal mitochondria in muscle tissue (HP:0008316)4.08887341
8Progressive macrocephaly (HP:0004481)3.99716681
9Acute encephalopathy (HP:0006846)3.99525056
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.77236478
11Congenital stationary night blindness (HP:0007642)3.73525601
12Hepatic necrosis (HP:0002605)3.66570157
13Reticulocytopenia (HP:0001896)3.63267942
14Pendular nystagmus (HP:0012043)3.58740128
15Abnormality of midbrain morphology (HP:0002418)3.57389841
16Molar tooth sign on MRI (HP:0002419)3.57389841
173-Methylglutaconic aciduria (HP:0003535)3.41181597
18Renal Fanconi syndrome (HP:0001994)3.19206905
19Abnormality of cells of the erythroid lineage (HP:0012130)3.13033517
20Abnormal rod and cone electroretinograms (HP:0008323)3.11692726
21Pancreatic cysts (HP:0001737)2.98707437
22Increased intramyocellular lipid droplets (HP:0012240)2.96899815
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95449287
24Abolished electroretinogram (ERG) (HP:0000550)2.94462860
25Optic disc pallor (HP:0000543)2.93659868
26Abnormality of alanine metabolism (HP:0010916)2.81583704
27Hyperalaninemia (HP:0003348)2.81583704
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81583704
29Cerebral edema (HP:0002181)2.80790910
30Rib fusion (HP:0000902)2.77265812
31Type II lissencephaly (HP:0007260)2.76735879
32Medial flaring of the eyebrow (HP:0010747)2.72037559
33Pancreatic fibrosis (HP:0100732)2.71776692
34Increased serum lactate (HP:0002151)2.70499633
35Dyschromatopsia (HP:0007641)2.70487180
36Abnormal number of erythroid precursors (HP:0012131)2.68865645
37Septo-optic dysplasia (HP:0100842)2.60301722
38Colon cancer (HP:0003003)2.56950464
39Increased muscle lipid content (HP:0009058)2.56852549
40Nephronophthisis (HP:0000090)2.56583226
41Abnormality of the renal cortex (HP:0011035)2.55530450
42Macrocytic anemia (HP:0001972)2.55470344
43True hermaphroditism (HP:0010459)2.53706912
44Attenuation of retinal blood vessels (HP:0007843)2.53432193
45Bony spicule pigmentary retinopathy (HP:0007737)2.47486678
46Abnormality of urine glucose concentration (HP:0011016)2.44702547
47Glycosuria (HP:0003076)2.44702547
48Absent thumb (HP:0009777)2.42318681
49Exertional dyspnea (HP:0002875)2.36400260
50Respiratory difficulties (HP:0002880)2.32245181
51Stomatitis (HP:0010280)2.31146970
52Abnormality of the labia minora (HP:0012880)2.29336428
53Renal cortical cysts (HP:0000803)2.29050622
54Lactic acidosis (HP:0003128)2.27179580
55Abnormality of renal resorption (HP:0011038)2.26796662
56Chorioretinal atrophy (HP:0000533)2.26627871
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21018098
58Hyperphosphaturia (HP:0003109)2.19454283
59Respiratory failure (HP:0002878)2.17050729
60Tubular atrophy (HP:0000092)2.15801559
61Abnormality of the renal medulla (HP:0100957)2.13327291
62Leukodystrophy (HP:0002415)2.11356922
63Gait imbalance (HP:0002141)2.11084703
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10306123
65Polydipsia (HP:0001959)2.09566209
66Abnormal drinking behavior (HP:0030082)2.09566209
67Congenital primary aphakia (HP:0007707)2.08766575
68Optic nerve hypoplasia (HP:0000609)2.07426781
69Type 2 muscle fiber atrophy (HP:0003554)2.06663073
70Absent septum pellucidum (HP:0001331)2.04898549
71IgG deficiency (HP:0004315)2.04123593
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03245760
73Increased corneal curvature (HP:0100692)2.02779107
74Keratoconus (HP:0000563)2.02779107
75Postaxial foot polydactyly (HP:0001830)1.98037454
76Pallor (HP:0000980)1.95495459
77Hypoplasia of the radius (HP:0002984)1.95460857
78Sclerocornea (HP:0000647)1.94780136
79Lethargy (HP:0001254)1.93699711
80Testicular atrophy (HP:0000029)1.92808515
81Exercise intolerance (HP:0003546)1.91988650
82Nephrogenic diabetes insipidus (HP:0009806)1.91244263
83Abnormality of the pons (HP:0007361)1.90269063
84Congenital, generalized hypertrichosis (HP:0004540)1.89855297
85Cerebellar dysplasia (HP:0007033)1.89483001
86Generalized aminoaciduria (HP:0002909)1.88223476
87Cystic liver disease (HP:0006706)1.83804757
88Abnormal urine phosphate concentration (HP:0012599)1.82147335
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78273730
90Abnormal protein N-linked glycosylation (HP:0012347)1.78273730
91Abnormal protein glycosylation (HP:0012346)1.78273730
92Abnormal glycosylation (HP:0012345)1.78273730
93Constricted visual fields (HP:0001133)1.76809678
94Severe visual impairment (HP:0001141)1.76487722
95Muscle fiber atrophy (HP:0100295)1.76023292
96Chronic hepatic failure (HP:0100626)1.75801372
97Abnormal pupillary function (HP:0007686)1.74532755
98Tachypnea (HP:0002789)1.74094067
99CNS demyelination (HP:0007305)1.71169706
100Hypoplasia of the ulna (HP:0003022)1.70886711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.58532308
2VRK24.40361440
3MUSK3.78506359
4ADRBK23.56443428
5WNK43.44757684
6TXK3.10185489
7FRK2.80886565
8GRK12.31348053
9TLK12.27797829
10ZAK2.11071526
11DYRK22.07578060
12PINK11.76511810
13STK391.59161707
14VRK11.57415328
15NME11.54589476
16NUAK11.49973303
17WNK31.43249063
18TAF11.42585325
19BCKDK1.38895079
20PAK31.36778115
21OXSR11.30599620
22MAPKAPK51.22315482
23BUB11.19261874
24CDK191.19120876
25TRIM281.14465300
26MAP3K121.12530693
27STK161.11948446
28BMPR1B1.09548303
29NLK1.04447893
30ADRBK11.04044043
31CDK81.02853301
32MAP4K11.02327597
33TNIK1.02165152
34LIMK11.01118044
35PRKCG0.99204455
36IKBKB0.98941007
37EIF2AK10.92460582
38CASK0.92079770
39TIE10.88085683
40DAPK30.86461852
41STK110.84777529
42EIF2AK30.82553480
43KDR0.82481379
44MAPK150.82403828
45INSRR0.77098802
46DAPK10.76910527
47MST40.76703543
48RPS6KA50.75779056
49PDK20.74488585
50PRKCQ0.73483402
51CSNK1G20.69531334
52LRRK20.68622822
53GRK50.65723647
54PIK3CA0.64664319
55EPHB20.63956816
56TAOK30.63692915
57CSNK1G30.62770925
58AURKA0.60425515
59WNK10.59052831
60CAMK10.57704803
61MKNK10.56071303
62DAPK20.53407077
63CSNK1G10.53312529
64PBK0.51657055
65PLK10.51224454
66PLK40.50122310
67EIF2AK20.48835710
68MAP2K20.47881774
69PRKCD0.46704992
70PRKACA0.45562252
71CSNK1A1L0.45266546
72PRKCI0.45143121
73CDC70.44011601
74NME20.43806200
75PLK30.43490993
76SYK0.43067016
77PRKCE0.43020002
78CSNK2A20.42838839
79CSNK2A10.42679407
80MKNK20.42676358
81CHUK0.42542758
82MINK10.41962536
83CAMK2A0.39143161
84MYLK0.38691561
85GRK70.38346171
86PRKCA0.38151693
87CSNK1E0.38105510
88MAPK130.38089914
89NTRK20.38065049
90AURKB0.36747123
91PLK20.34956346
92FGFR10.34436425
93CHEK20.33982663
94OBSCN0.33893044
95FES0.33519171
96TEC0.32382411
97BTK0.32272968
98PHKG20.32100327
99PHKG10.32100327
100PKN10.31541748

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.98085425
2Oxidative phosphorylation_Homo sapiens_hsa001904.17512988
3Parkinsons disease_Homo sapiens_hsa050123.52675646
4RNA polymerase_Homo sapiens_hsa030203.17905755
5Proteasome_Homo sapiens_hsa030502.97047343
6Huntingtons disease_Homo sapiens_hsa050162.48172096
7Alzheimers disease_Homo sapiens_hsa050102.36487339
8Cardiac muscle contraction_Homo sapiens_hsa042602.35267882
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34432331
10Protein export_Homo sapiens_hsa030602.11871746
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03945410
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98287644
13Nitrogen metabolism_Homo sapiens_hsa009101.96563208
14Linoleic acid metabolism_Homo sapiens_hsa005911.91257159
15One carbon pool by folate_Homo sapiens_hsa006701.89756829
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81767401
17Basal transcription factors_Homo sapiens_hsa030221.81483597
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77473695
19Homologous recombination_Homo sapiens_hsa034401.72869916
20Primary immunodeficiency_Homo sapiens_hsa053401.64701808
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63289832
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57130655
23RNA degradation_Homo sapiens_hsa030181.50386126
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48132274
25Pyrimidine metabolism_Homo sapiens_hsa002401.37703334
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35262908
27Phototransduction_Homo sapiens_hsa047441.34717547
28Caffeine metabolism_Homo sapiens_hsa002321.29819653
29Chemical carcinogenesis_Homo sapiens_hsa052041.26298997
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25799284
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25656456
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22653593
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19525535
34Folate biosynthesis_Homo sapiens_hsa007901.17353000
35Nicotine addiction_Homo sapiens_hsa050331.17027425
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.15071538
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14813536
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.08675248
39Peroxisome_Homo sapiens_hsa041461.03447549
40Butanoate metabolism_Homo sapiens_hsa006501.01578578
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00604313
42Sulfur metabolism_Homo sapiens_hsa009200.99852229
43Asthma_Homo sapiens_hsa053100.99082259
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98900685
45Nucleotide excision repair_Homo sapiens_hsa034200.95127796
46Propanoate metabolism_Homo sapiens_hsa006400.94414346
47Retinol metabolism_Homo sapiens_hsa008300.92456166
48Vitamin B6 metabolism_Homo sapiens_hsa007500.92223635
49Mineral absorption_Homo sapiens_hsa049780.89765261
50Ether lipid metabolism_Homo sapiens_hsa005650.86629943
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86443507
52Purine metabolism_Homo sapiens_hsa002300.84348750
53Selenocompound metabolism_Homo sapiens_hsa004500.82548263
54Tryptophan metabolism_Homo sapiens_hsa003800.79216995
55Taste transduction_Homo sapiens_hsa047420.79175611
56Metabolic pathways_Homo sapiens_hsa011000.74266720
57Mismatch repair_Homo sapiens_hsa034300.73994942
58Fanconi anemia pathway_Homo sapiens_hsa034600.71786372
59Allograft rejection_Homo sapiens_hsa053300.70397435
60Fat digestion and absorption_Homo sapiens_hsa049750.68681909
61Autoimmune thyroid disease_Homo sapiens_hsa053200.66198391
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.66175263
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64717999
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.59412816
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.59084559
66Arachidonic acid metabolism_Homo sapiens_hsa005900.57735587
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56997773
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56982975
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56355713
70Starch and sucrose metabolism_Homo sapiens_hsa005000.55398220
71Hematopoietic cell lineage_Homo sapiens_hsa046400.52135957
72Vitamin digestion and absorption_Homo sapiens_hsa049770.51539439
73Graft-versus-host disease_Homo sapiens_hsa053320.47730170
74RNA transport_Homo sapiens_hsa030130.47239738
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47216901
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46236239
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46062036
78Olfactory transduction_Homo sapiens_hsa047400.40968889
79Base excision repair_Homo sapiens_hsa034100.40914826
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39554754
81Spliceosome_Homo sapiens_hsa030400.38677180
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37554990
83Morphine addiction_Homo sapiens_hsa050320.36192801
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.35367035
85Salivary secretion_Homo sapiens_hsa049700.35346136
86Fatty acid degradation_Homo sapiens_hsa000710.34738304
87Type I diabetes mellitus_Homo sapiens_hsa049400.34237012
88Pyruvate metabolism_Homo sapiens_hsa006200.33829609
89Antigen processing and presentation_Homo sapiens_hsa046120.33808634
90Sulfur relay system_Homo sapiens_hsa041220.32771382
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32139220
92Circadian rhythm_Homo sapiens_hsa047100.31148671
93T cell receptor signaling pathway_Homo sapiens_hsa046600.30292935
94Glycerolipid metabolism_Homo sapiens_hsa005610.29810552
95Hedgehog signaling pathway_Homo sapiens_hsa043400.27543202
96Glutathione metabolism_Homo sapiens_hsa004800.27460019
97Ovarian steroidogenesis_Homo sapiens_hsa049130.27408016
98Basal cell carcinoma_Homo sapiens_hsa052170.26577663
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26299002
100DNA replication_Homo sapiens_hsa030300.25556739

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