ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.13933065
2	ATP synthesis coupled proton transport (GO:0015986)	5.13933065
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.95902780
4	DNA deamination (GO:0045006)	4.88043834
5	protein complex biogenesis (GO:0070271)	4.75191641
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.69320483
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.51506128
8	NADH dehydrogenase complex assembly (GO:0010257)	4.51506128
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.51506128
10	mitochondrial respiratory chain complex assembly (GO:0033108)	4.35920045
11	ribosomal small subunit assembly (GO:0000028)	4.32597872
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21799369
13	protein neddylation (GO:0045116)	4.03458805
14	chaperone-mediated protein transport (GO:0072321)	3.99550169
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.95245632
16	maturation of SSU-rRNA (GO:0030490)	3.93452314
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.93116593
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.93116593
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.87927284
20	behavioral response to nicotine (GO:0035095)	3.84502871
21	viral transcription (GO:0019083)	3.81521692
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.78805751
23	respiratory electron transport chain (GO:0022904)	3.76500547
24	translational termination (GO:0006415)	3.76204300
25	electron transport chain (GO:0022900)	3.74960426
26	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.65638128
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.62451509
28	cotranslational protein targeting to membrane (GO:0006613)	3.61599366
29	protein targeting to ER (GO:0045047)	3.56755102
30	cytochrome complex assembly (GO:0017004)	3.40523690
31	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.40319064
32	protein localization to endoplasmic reticulum (GO:0070972)	3.39687742
33	platelet dense granule organization (GO:0060155)	3.37438254
34	protein-cofactor linkage (GO:0018065)	3.35418459
35	translational elongation (GO:0006414)	3.34948040
36	proteasome assembly (GO:0043248)	3.34889902
37	respiratory chain complex IV assembly (GO:0008535)	3.31893864
38	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31569411
39	mannosylation (GO:0097502)	3.31271991
40	ribosomal large subunit biogenesis (GO:0042273)	3.26572554
41	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.15186181
42	termination of RNA polymerase III transcription (GO:0006386)	3.15186181
43	maturation of 5.8S rRNA (GO:0000460)	3.13918824
44	translation (GO:0006412)	3.12815873
45	ribosomal small subunit biogenesis (GO:0042274)	3.11150152
46	chromatin remodeling at centromere (GO:0031055)	3.10638195
47	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.06528206
48	regulation of mitotic spindle checkpoint (GO:1903504)	3.06528206
49	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.05868310
50	protein deneddylation (GO:0000338)	3.02396211
51	cullin deneddylation (GO:0010388)	3.01387288
52	GPI anchor metabolic process (GO:0006505)	3.00042715
53	regulation of mitochondrial translation (GO:0070129)	2.97356777
54	cellular component biogenesis (GO:0044085)	2.96690293
55	ATP biosynthetic process (GO:0006754)	2.94606027
56	pseudouridine synthesis (GO:0001522)	2.94567777
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.94335822
58	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.92967353
59	CENP-A containing nucleosome assembly (GO:0034080)	2.92215098
60	GPI anchor biosynthetic process (GO:0006506)	2.90505569
61	tRNA processing (GO:0008033)	2.88274792
62	GTP biosynthetic process (GO:0006183)	2.87778219
63	hydrogen ion transmembrane transport (GO:1902600)	2.86991837
64	viral life cycle (GO:0019058)	2.86825219
65	cytidine deamination (GO:0009972)	2.86334302
66	cytidine metabolic process (GO:0046087)	2.86334302
67	cytidine catabolic process (GO:0006216)	2.86334302
68	translational initiation (GO:0006413)	2.83645617
69	response to pheromone (GO:0019236)	2.83258032
70	L-fucose catabolic process (GO:0042355)	2.82788017
71	fucose catabolic process (GO:0019317)	2.82788017
72	L-fucose metabolic process (GO:0042354)	2.82788017
73	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.79807062
74	cellular protein complex disassembly (GO:0043624)	2.77048541
75	proton transport (GO:0015992)	2.75989512
76	piRNA metabolic process (GO:0034587)	2.75825635
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.73843734
78	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.72183503
79	DNA double-strand break processing (GO:0000729)	2.70958608
80	hydrogen transport (GO:0006818)	2.70712677
81	negative regulation of telomere maintenance (GO:0032205)	2.67499620
82	base-excision repair, AP site formation (GO:0006285)	2.65012069
83	indolalkylamine metabolic process (GO:0006586)	2.63430221
84	rRNA processing (GO:0006364)	2.63277096
85	rRNA metabolic process (GO:0016072)	2.63177569
86	intracellular protein transmembrane import (GO:0044743)	2.61690595
87	iron-sulfur cluster assembly (GO:0016226)	2.61433880
88	metallo-sulfur cluster assembly (GO:0031163)	2.61433880
89	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.58778475
90	kynurenine metabolic process (GO:0070189)	2.58715687
91	ubiquinone biosynthetic process (GO:0006744)	2.58502255
92	rRNA modification (GO:0000154)	2.58446795
93	DNA replication checkpoint (GO:0000076)	2.57478354
94	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.56869533
95	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.55021822
96	indole-containing compound catabolic process (GO:0042436)	2.54235408
97	indolalkylamine catabolic process (GO:0046218)	2.54235408
98	tryptophan catabolic process (GO:0006569)	2.54235408
99	oxidative phosphorylation (GO:0006119)	2.52098108
100	peptidyl-histidine modification (GO:0018202)	2.51587437

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.33362498
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.23412051
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.65349102
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.29273118
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.22361389
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.98378798
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.90441214
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.82635071
9	VDR_22108803_ChIP-Seq_LS180_Human	2.80711722
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73897921
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.68378604
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.63316114
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.61895889
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.52377052
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.39102911
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.29675933
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.23612509
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.20193757
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11701003
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.10380445
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.09175438
22	EWS_26573619_Chip-Seq_HEK293_Human	1.98758302
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98321755
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.86973794
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83626201
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82128164
27	FUS_26573619_Chip-Seq_HEK293_Human	1.75379418
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63664572
29	TTF2_22483619_ChIP-Seq_HELA_Human	1.62389582
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61125862
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57860164
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54564409
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.53950871
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50003407
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.49444233
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.44948286
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.43496093
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42181101
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40684785
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.37421633
41	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36615079
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36090070
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35823419
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35696864
45	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.31120404
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30653057
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29866285
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29866285
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28692291
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.27489956
51	AR_20517297_ChIP-Seq_VCAP_Human	1.26551192
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26368203
53	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.22727954
54	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22618936
55	P300_19829295_ChIP-Seq_ESCs_Human	1.21406424
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20657110
57	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.18489486
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.17618851
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16139586
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16081797
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15039112
62	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.13681255
63	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.13451869
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.12647724
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12647724
66	EZH2_22144423_ChIP-Seq_EOC_Human	1.12159013
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11547106
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.09822432
69	NCOR_22424771_ChIP-Seq_293T_Human	1.09341096
70	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.08294714
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07945702
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06518767
73	CIITA_25753668_ChIP-Seq_RAJI_Human	1.06474292
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05232159
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05232159
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01295673
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00533041
78	GATA3_26560356_Chip-Seq_TH2_Human	1.00507149
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00192974
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.00049422
81	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.98735084
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98513388
83	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98406939
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95116260
85	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.94627686
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93210743
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93068147
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92327784
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91726853
90	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91538629
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90892819
92	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.89821773
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89722289
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89125265
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88835207
96	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.88559052
97	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.88522056
98	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88198196
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86832864
100	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.86473173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.82829347
2	MP0009379_abnormal_foot_pigmentation	3.53615245
3	MP0008877_abnormal_DNA_methylation	2.96179351
4	MP0006072_abnormal_retinal_apoptosis	2.72794875
5	MP0002102_abnormal_ear_morphology	2.62231056
6	MP0002837_dystrophic_cardiac_calcinosis	2.35637472
7	MP0005671_abnormal_response_to	2.19555373
8	MP0004147_increased_porphyrin_level	1.94281503
9	MP0002163_abnormal_gland_morphology	1.93442253
10	MP0008058_abnormal_DNA_repair	1.93326021
11	MP0001529_abnormal_vocalization	1.91759160
12	MP0003787_abnormal_imprinting	1.91490421
13	MP0004142_abnormal_muscle_tone	1.85837648
14	MP0005551_abnormal_eye_electrophysiolog	1.80672145
15	MP0002234_abnormal_pharynx_morphology	1.74833601
16	MP0005646_abnormal_pituitary_gland	1.72859355
17	MP0005084_abnormal_gallbladder_morpholo	1.72566405
18	MP0002736_abnormal_nociception_after	1.71280923
19	MP0005645_abnormal_hypothalamus_physiol	1.66797667
20	MP0008789_abnormal_olfactory_epithelium	1.64715022
21	MP0008875_abnormal_xenobiotic_pharmacok	1.62484615
22	MP0003786_premature_aging	1.61648147
23	MP0003646_muscle_fatigue	1.60008282
24	MP0008872_abnormal_physiological_respon	1.58047279
25	MP0003693_abnormal_embryo_hatching	1.57844171
26	MP0001968_abnormal_touch/_nociception	1.54749395
27	MP0002876_abnormal_thyroid_physiology	1.54658495
28	MP0000372_irregular_coat_pigmentation	1.51103835
29	MP0003195_calcinosis	1.50899834
30	MP0004885_abnormal_endolymph	1.47563348
31	MP0005389_reproductive_system_phenotype	1.47204400
32	MP0005253_abnormal_eye_physiology	1.47021601
33	MP0005379_endocrine/exocrine_gland_phen	1.44591934
34	MP0002653_abnormal_ependyma_morphology	1.44336677
35	MP0005075_abnormal_melanosome_morpholog	1.43461529
36	MP0001293_anophthalmia	1.42430268
37	MP0003806_abnormal_nucleotide_metabolis	1.42277876
38	MP0001188_hyperpigmentation	1.41978119
39	MP0010094_abnormal_chromosome_stability	1.38300955
40	MP0001905_abnormal_dopamine_level	1.38189300
41	MP0002938_white_spotting	1.37265852
42	MP0003880_abnormal_central_pattern	1.36512102
43	MP0003011_delayed_dark_adaptation	1.35183311
44	MP0001986_abnormal_taste_sensitivity	1.32656545
45	MP0000631_abnormal_neuroendocrine_gland	1.28734900
46	MP0002277_abnormal_respiratory_mucosa	1.27056243
47	MP0006036_abnormal_mitochondrial_physio	1.25375317
48	MP0008995_early_reproductive_senescence	1.24688734
49	MP0001919_abnormal_reproductive_system	1.23479581
50	MP0001835_abnormal_antigen_presentation	1.23240494
51	MP0002138_abnormal_hepatobiliary_system	1.20155231
52	MP0003567_abnormal_fetal_cardiomyocyte	1.19475066
53	MP0002160_abnormal_reproductive_system	1.19055573
54	MP0006276_abnormal_autonomic_nervous	1.18471869
55	MP0001984_abnormal_olfaction	1.17776435
56	MP0002272_abnormal_nervous_system	1.15990411
57	MP0001485_abnormal_pinna_reflex	1.15213476
58	MP0002095_abnormal_skin_pigmentation	1.14450363
59	MP0000049_abnormal_middle_ear	1.12056529
60	MP0002638_abnormal_pupillary_reflex	1.11156617
61	MP0003718_maternal_effect	1.09217861
62	MP0009745_abnormal_behavioral_response	1.08043284
63	MP0009046_muscle_twitch	1.06361338
64	MP0003186_abnormal_redox_activity	1.06360306
65	MP0005394_taste/olfaction_phenotype	1.05275850
66	MP0005499_abnormal_olfactory_system	1.05275850
67	MP0000427_abnormal_hair_cycle	1.01033906
68	MP0005332_abnormal_amino_acid	0.99598756
69	MP0005174_abnormal_tail_pigmentation	0.99062655
70	MP0003121_genomic_imprinting	0.98191389
71	MP0006035_abnormal_mitochondrial_morpho	0.98032775
72	MP0004145_abnormal_muscle_electrophysio	0.96686743
73	MP0003878_abnormal_ear_physiology	0.94072719
74	MP0005377_hearing/vestibular/ear_phenot	0.94072719
75	MP0001764_abnormal_homeostasis	0.92200125
76	MP0002148_abnormal_hypersensitivity_rea	0.91825834
77	MP0003283_abnormal_digestive_organ	0.91369552
78	MP0002210_abnormal_sex_determination	0.90142169
79	MP0005195_abnormal_posterior_eye	0.88906551
80	MP0001929_abnormal_gametogenesis	0.87412884
81	MP0000685_abnormal_immune_system	0.86141791
82	MP0004957_abnormal_blastocyst_morpholog	0.84475433
83	MP0003122_maternal_imprinting	0.82144286
84	MP0000653_abnormal_sex_gland	0.80572715
85	MP0002751_abnormal_autonomic_nervous	0.80165450
86	MP0002733_abnormal_thermal_nociception	0.78878533
87	MP0001145_abnormal_male_reproductive	0.77946558
88	MP0005410_abnormal_fertilization	0.77233516
89	MP0001486_abnormal_startle_reflex	0.76823997
90	MP0003252_abnormal_bile_duct	0.75973218
91	MP0005636_abnormal_mineral_homeostasis	0.75943425
92	MP0001970_abnormal_pain_threshold	0.73127889
93	MP0001119_abnormal_female_reproductive	0.72001267
94	MP0003866_abnormal_defecation	0.71607549
95	MP0004133_heterotaxia	0.71572115
96	MP0009764_decreased_sensitivity_to	0.71088202
97	MP0001800_abnormal_humoral_immune	0.69822481
98	MP0009785_altered_susceptibility_to	0.68435571
99	MP0002557_abnormal_social/conspecific_i	0.66829104
100	MP0001501_abnormal_sleep_pattern	0.65756336

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.37081402
2	Mitochondrial inheritance (HP:0001427)	4.04427487
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.90501963
4	Increased CSF lactate (HP:0002490)	3.76509034
5	Acute encephalopathy (HP:0006846)	3.73414930
6	Progressive macrocephaly (HP:0004481)	3.73395252
7	Hepatocellular necrosis (HP:0001404)	3.52541678
8	Pancreatic cysts (HP:0001737)	3.51707863
9	3-Methylglutaconic aciduria (HP:0003535)	3.42867573
10	Abnormality of midbrain morphology (HP:0002418)	3.33140291
11	Molar tooth sign on MRI (HP:0002419)	3.33140291
12	Hepatic necrosis (HP:0002605)	3.32640871
13	Increased hepatocellular lipid droplets (HP:0006565)	3.23944218
14	Pancreatic fibrosis (HP:0100732)	3.14661729
15	Lipid accumulation in hepatocytes (HP:0006561)	3.13352757
16	True hermaphroditism (HP:0010459)	3.03623110
17	Cerebral edema (HP:0002181)	3.02804850
18	Congenital stationary night blindness (HP:0007642)	3.02514997
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.87605109
20	Increased serum lactate (HP:0002151)	2.80578251
21	Congenital, generalized hypertrichosis (HP:0004540)	2.75956329
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.74923740
23	Methylmalonic acidemia (HP:0002912)	2.74149670
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.71789127
25	Abnormality of alanine metabolism (HP:0010916)	2.71789127
26	Hyperalaninemia (HP:0003348)	2.71789127
27	Nephronophthisis (HP:0000090)	2.69194637
28	Pendular nystagmus (HP:0012043)	2.68146527
29	Reticulocytopenia (HP:0001896)	2.66682281
30	Abnormality of cells of the erythroid lineage (HP:0012130)	2.64388986
31	Optic disc pallor (HP:0000543)	2.63182774
32	Abolished electroretinogram (ERG) (HP:0000550)	2.61439961
33	Medial flaring of the eyebrow (HP:0010747)	2.60357542
34	Lactic acidosis (HP:0003128)	2.57363680
35	Abnormal number of erythroid precursors (HP:0012131)	2.55310354
36	Renal Fanconi syndrome (HP:0001994)	2.50289808
37	Type II lissencephaly (HP:0007260)	2.44951706
38	Sclerocornea (HP:0000647)	2.37144270
39	IgG deficiency (HP:0004315)	2.34560020
40	Colon cancer (HP:0003003)	2.33801756
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.33160891
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.33160891
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.30352605
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.28093568
45	Macrocytic anemia (HP:0001972)	2.27362531
46	Absent thumb (HP:0009777)	2.26352792
47	Methylmalonic aciduria (HP:0012120)	2.26214032
48	Increased intramyocellular lipid droplets (HP:0012240)	2.25654722
49	Respiratory failure (HP:0002878)	2.19737193
50	Lethargy (HP:0001254)	2.17604842
51	Exertional dyspnea (HP:0002875)	2.15917797
52	Attenuation of retinal blood vessels (HP:0007843)	2.14216828
53	Abnormality of the renal cortex (HP:0011035)	2.13344599
54	Abnormality of the renal medulla (HP:0100957)	2.09697579
55	Renal cortical cysts (HP:0000803)	2.03205438
56	Hyperglycinemia (HP:0002154)	2.01216239
57	Aplasia/hypoplasia of the uterus (HP:0008684)	2.00341100
58	Absent/shortened dynein arms (HP:0200106)	1.99525833
59	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99525833
60	Decreased central vision (HP:0007663)	1.95836493
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95741870
62	Type I transferrin isoform profile (HP:0003642)	1.94517604
63	Cystic liver disease (HP:0006706)	1.94322680
64	Glycosuria (HP:0003076)	1.94317103
65	Abnormality of urine glucose concentration (HP:0011016)	1.94317103
66	Congenital primary aphakia (HP:0007707)	1.92097889
67	Leukodystrophy (HP:0002415)	1.91215525
68	Abnormality of the renal collecting system (HP:0004742)	1.87660019
69	Gait imbalance (HP:0002141)	1.86595262
70	Increased muscle lipid content (HP:0009058)	1.85317581
71	Nephrogenic diabetes insipidus (HP:0009806)	1.83630707
72	Severe combined immunodeficiency (HP:0004430)	1.83086277
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82204142
74	Abnormality of the labia minora (HP:0012880)	1.82070173
75	Exercise intolerance (HP:0003546)	1.82052470
76	Type 2 muscle fiber atrophy (HP:0003554)	1.81476709
77	Postaxial foot polydactyly (HP:0001830)	1.80776673
78	Abnormality of the prostate (HP:0008775)	1.80422498
79	Abnormality of serum amino acid levels (HP:0003112)	1.79741617
80	Abnormality of renal resorption (HP:0011038)	1.79534859
81	Progressive microcephaly (HP:0000253)	1.78348078
82	Anencephaly (HP:0002323)	1.75822157
83	Increased corneal curvature (HP:0100692)	1.75188465
84	Keratoconus (HP:0000563)	1.75188465
85	Pancytopenia (HP:0001876)	1.74130187
86	Abnormality of vitamin B metabolism (HP:0004340)	1.73778141
87	Asplenia (HP:0001746)	1.73707356
88	Short tibia (HP:0005736)	1.73611351
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73400838
90	Aplastic anemia (HP:0001915)	1.72815139
91	Male pseudohermaphroditism (HP:0000037)	1.72711863
92	Hypoplasia of the uterus (HP:0000013)	1.72370778
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72300502
94	Pallor (HP:0000980)	1.71965033
95	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.71780192
96	Abnormal protein N-linked glycosylation (HP:0012347)	1.71780192
97	Abnormal protein glycosylation (HP:0012346)	1.71780192
98	Abnormal glycosylation (HP:0012345)	1.71780192
99	Constricted visual fields (HP:0001133)	1.70943753
100	Elevated erythrocyte sedimentation rate (HP:0003565)	1.70680339

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.67556889
2	MAP4K2	3.19785676
3	BCKDK	3.16690681
4	FRK	2.85992373
5	ZAK	2.81078760
6	NUAK1	2.79546685
7	TLK1	2.57942534
8	TXK	2.42707217
9	STK16	2.29283399
10	TAOK3	2.23454079
11	BUB1	2.20910056
12	ADRBK2	2.07782346
13	BMPR1B	2.03172400
14	GRK1	1.97595640
15	TAF1	1.91987200
16	EIF2AK3	1.89041944
17	CDK19	1.76379070
18	WNK3	1.72697525
19	VRK1	1.68839377
20	CDC7	1.46916722
21	PLK4	1.42908700
22	TRIM28	1.41246496
23	PINK1	1.39602646
24	WNK4	1.29758347
25	MST4	1.28211900
26	CSNK1G3	1.24821515
27	NEK1	1.22956747
28	DYRK2	1.22199903
29	EIF2AK1	1.22073405
30	PLK3	1.18929354
31	MAP3K12	1.13399639
32	CDK8	1.12913940
33	OXSR1	1.09971651
34	SRPK1	1.06869873
35	CSNK1G2	1.06639541
36	TIE1	1.04055267
37	CSNK1G1	0.99036013
38	ERBB3	0.98570257
39	RPS6KA4	0.98380315
40	INSRR	0.95819779
41	PLK2	0.95131667
42	KDR	0.94990340
43	EIF2AK2	0.94306261
44	TESK2	0.89246286
45	WEE1	0.89026498
46	CSNK1A1L	0.88250234
47	KIT	0.87202271
48	MAPK13	0.84493753
49	MKNK2	0.84275788
50	LIMK1	0.82938544
51	ACVR1B	0.81937000
52	MKNK1	0.81288383
53	TEC	0.80539604
54	PHKG2	0.80429853
55	PHKG1	0.80429853
56	PLK1	0.75664040
57	GRK6	0.73513383
58	RPS6KA5	0.72647990
59	PASK	0.72535674
60	ATR	0.72378960
61	BCR	0.70588087
62	IKBKB	0.67613394
63	MAPKAPK5	0.67008142
64	GRK5	0.66511833
65	MAP3K4	0.65547287
66	STK39	0.64030162
67	AURKB	0.63780932
68	DAPK1	0.63762164
69	MAP2K7	0.62974915
70	GRK7	0.62883787
71	CHEK2	0.62015597
72	PRKCI	0.61071352
73	SYK	0.60887686
74	NME1	0.60201030
75	PRKCG	0.59922660
76	PRKCE	0.59778734
77	MAPKAPK3	0.59260694
78	BRSK2	0.58998857
79	ITK	0.56500316
80	ADRBK1	0.55667947
81	PRKCQ	0.54341135
82	TGFBR1	0.53579690
83	CSNK2A1	0.53510359
84	NEK2	0.51144084
85	NME2	0.51130832
86	CSNK2A2	0.46264735
87	TNIK	0.45907118
88	PIK3CA	0.45107159
89	AURKA	0.44862804
90	MAP4K1	0.42162197
91	BMPR2	0.41211216
92	MAP2K2	0.41057443
93	CSNK1A1	0.39615468
94	MAP2K6	0.38871037
95	TTK	0.38113406
96	PRKACA	0.37607354
97	ILK	0.37424330
98	FLT3	0.36757238
99	DAPK2	0.35814178
100	LYN	0.35418511

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.81422889
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.75690424
3	Protein export_Homo sapiens_hsa03060	3.18917542
4	Proteasome_Homo sapiens_hsa03050	3.13749880
5	Parkinsons disease_Homo sapiens_hsa05012	3.09426885
6	RNA polymerase_Homo sapiens_hsa03020	2.50505851
7	Homologous recombination_Homo sapiens_hsa03440	2.22895040
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18087409
9	Asthma_Homo sapiens_hsa05310	2.10549550
10	Huntingtons disease_Homo sapiens_hsa05016	2.06669493
11	Alzheimers disease_Homo sapiens_hsa05010	1.99297949
12	Mismatch repair_Homo sapiens_hsa03430	1.90592516
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.89142862
14	RNA degradation_Homo sapiens_hsa03018	1.85542855
15	DNA replication_Homo sapiens_hsa03030	1.83936112
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80631606
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.76141847
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.72091533
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68289118
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.66900750
21	Phototransduction_Homo sapiens_hsa04744	1.66026204
22	Basal transcription factors_Homo sapiens_hsa03022	1.60127827
23	Sulfur relay system_Homo sapiens_hsa04122	1.57888720
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53893971
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.52312328
26	Allograft rejection_Homo sapiens_hsa05330	1.51683956
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.51185944
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.49398939
29	Caffeine metabolism_Homo sapiens_hsa00232	1.48994584
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.47859127
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44952382
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.38709073
33	One carbon pool by folate_Homo sapiens_hsa00670	1.35889703
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.31718453
35	Spliceosome_Homo sapiens_hsa03040	1.29570734
36	Propanoate metabolism_Homo sapiens_hsa00640	1.28546554
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25354902
38	Base excision repair_Homo sapiens_hsa03410	1.22796402
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22721921
40	Primary immunodeficiency_Homo sapiens_hsa05340	1.21555951
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.13407526
42	Purine metabolism_Homo sapiens_hsa00230	1.11515571
43	RNA transport_Homo sapiens_hsa03013	1.11263077
44	Sulfur metabolism_Homo sapiens_hsa00920	1.10105347
45	Butanoate metabolism_Homo sapiens_hsa00650	1.07075139
46	Non-homologous end-joining_Homo sapiens_hsa03450	1.02770756
47	Fatty acid elongation_Homo sapiens_hsa00062	1.01350583
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99101911
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97616254
50	Antigen processing and presentation_Homo sapiens_hsa04612	0.97294498
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95123974
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.92630322
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91435126
54	Peroxisome_Homo sapiens_hsa04146	0.90253268
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87399333
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.87089964
57	Regulation of autophagy_Homo sapiens_hsa04140	0.86192820
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83244061
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82292208
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81922935
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81591526
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78685059
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.76020865
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74631989
65	Folate biosynthesis_Homo sapiens_hsa00790	0.70753636
66	Metabolic pathways_Homo sapiens_hsa01100	0.68310260
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66565778
68	Olfactory transduction_Homo sapiens_hsa04740	0.66218602
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65781930
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.62784585
71	Retinol metabolism_Homo sapiens_hsa00830	0.59213325
72	Nicotine addiction_Homo sapiens_hsa05033	0.59003692
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58574220
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55689609
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53597450
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52875871
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51288711
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49682740
79	Glutathione metabolism_Homo sapiens_hsa00480	0.48229725
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46325500
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.45974472
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44165767
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40186412
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.40004987
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38788823
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37544861
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37345915
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.35809544
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34654740
90	Taste transduction_Homo sapiens_hsa04742	0.34639337
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32967491
92	p53 signaling pathway_Homo sapiens_hsa04115	0.32325472
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.30878452
94	Morphine addiction_Homo sapiens_hsa05032	0.29514316
95	Fatty acid degradation_Homo sapiens_hsa00071	0.26853870
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.26785702
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25738441
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24487678
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22949477
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.21630890

RPL12P38

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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