ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.89796891
2	viral transcription (GO:0019083)	7.03603006
3	translational termination (GO:0006415)	6.96852722
4	maturation of SSU-rRNA (GO:0030490)	6.56670393
5	ribosomal small subunit biogenesis (GO:0042274)	5.74058320
6	translational elongation (GO:0006414)	5.42909762
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.41873734
8	protein targeting to ER (GO:0045047)	5.40192095
9	cotranslational protein targeting to membrane (GO:0006613)	5.38387585
10	cellular protein complex disassembly (GO:0043624)	5.25108893
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.17303549
12	regulation of meiosis I (GO:0060631)	5.07733877
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.05986299
14	ATP synthesis coupled proton transport (GO:0015986)	5.05986299
15	protein localization to endoplasmic reticulum (GO:0070972)	5.00258324
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.00240654
17	viral life cycle (GO:0019058)	4.90222225
18	ribosomal large subunit biogenesis (GO:0042273)	4.77707627
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.71605814
20	protein neddylation (GO:0045116)	4.62657595
21	protein complex disassembly (GO:0043241)	4.43124430
22	macromolecular complex disassembly (GO:0032984)	4.24566394
23	negative regulation of nitric-oxide synthase activity (GO:0051001)	4.13061493
24	translational initiation (GO:0006413)	4.10359282
25	DNA deamination (GO:0045006)	3.99060620
26	somite development (GO:0061053)	3.90548051
27	behavioral response to nicotine (GO:0035095)	3.87390978
28	kynurenine metabolic process (GO:0070189)	3.85272424
29	response to pheromone (GO:0019236)	3.63126601
30	negative regulation of catenin import into nucleus (GO:0035414)	3.62929261
31	transmission of nerve impulse (GO:0019226)	3.59065648
32	rRNA modification (GO:0000154)	3.57456094
33	protein K6-linked ubiquitination (GO:0085020)	3.51012948
34	positive regulation of meiosis (GO:0045836)	3.50998834
35	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.47007542
36	protein targeting to membrane (GO:0006612)	3.41660787
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38213207
38	mRNA catabolic process (GO:0006402)	3.30772679
39	positive regulation of meiotic cell cycle (GO:0051446)	3.27091698
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.26760662
41	indole-containing compound catabolic process (GO:0042436)	3.24924350
42	indolalkylamine catabolic process (GO:0046218)	3.24924350
43	tryptophan catabolic process (GO:0006569)	3.24924350
44	heart trabecula morphogenesis (GO:0061384)	3.24030322
45	translation (GO:0006412)	3.18189274
46	negative regulation of mast cell activation (GO:0033004)	3.13417828
47	negative regulation of organelle assembly (GO:1902116)	3.13189923
48	respiratory electron transport chain (GO:0022904)	3.12893982
49	electron transport chain (GO:0022900)	3.10035248
50	spindle assembly involved in mitosis (GO:0090307)	3.09834592
51	nonmotile primary cilium assembly (GO:0035058)	3.03828435
52	sperm motility (GO:0030317)	3.03106089
53	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.01417600
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.01209387
55	kidney morphogenesis (GO:0060993)	2.99291562
56	detection of light stimulus involved in sensory perception (GO:0050962)	2.97068384
57	detection of light stimulus involved in visual perception (GO:0050908)	2.97068384
58	hydrogen ion transmembrane transport (GO:1902600)	2.96771660
59	multicellular organism reproduction (GO:0032504)	2.96505508
60	rRNA methylation (GO:0031167)	2.96203394
61	negative regulation of neurotransmitter transport (GO:0051589)	2.94276812
62	axonemal dynein complex assembly (GO:0070286)	2.93768798
63	RNA catabolic process (GO:0006401)	2.92505733
64	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90917834
65	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90917834
66	NADH dehydrogenase complex assembly (GO:0010257)	2.90917834
67	ribonucleoprotein complex biogenesis (GO:0022613)	2.90305952
68	lung-associated mesenchyme development (GO:0060484)	2.88661437
69	proteasome assembly (GO:0043248)	2.88554683
70	negative regulation of neurotransmitter secretion (GO:0046929)	2.87326520
71	lung epithelium development (GO:0060428)	2.86768592
72	aromatic amino acid family catabolic process (GO:0009074)	2.86049067
73	ovulation cycle (GO:0042698)	2.84766304
74	metanephric tubule development (GO:0072170)	2.82720946
75	metanephric nephron tubule development (GO:0072234)	2.82720946
76	ATP biosynthetic process (GO:0006754)	2.82479428
77	chaperone-mediated protein transport (GO:0072321)	2.81866761
78	sulfation (GO:0051923)	2.81081634
79	parturition (GO:0007567)	2.78024800
80	protein complex biogenesis (GO:0070271)	2.74461418
81	regulation of action potential (GO:0098900)	2.72242521
82	cell proliferation in forebrain (GO:0021846)	2.71894223
83	oxidative demethylation (GO:0070989)	2.71835523
84	positive regulation of gastrulation (GO:2000543)	2.71766492
85	proton transport (GO:0015992)	2.70141968
86	startle response (GO:0001964)	2.68364881
87	indolalkylamine metabolic process (GO:0006586)	2.67241520
88	synapsis (GO:0007129)	2.66109745
89	regulation of mesoderm development (GO:2000380)	2.64071169
90	cellular component biogenesis (GO:0044085)	2.63505908
91	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.63201751
92	hydrogen transport (GO:0006818)	2.62027113
93	primary amino compound metabolic process (GO:1901160)	2.61135973
94	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.60256918
95	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.58817939
96	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.58817939
97	lung morphogenesis (GO:0060425)	2.56620408
98	spinal cord development (GO:0021510)	2.52757013
99	pyrimidine nucleobase catabolic process (GO:0006208)	2.52743317
100	neural tube formation (GO:0001841)	2.50852850

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.58087819
2	VDR_22108803_ChIP-Seq_LS180_Human	2.74981214
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.67232557
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.66288664
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57044456
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50155111
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.24998633
8	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.24686307
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.22927154
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.16019882
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.13627181
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.97533587
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.88553708
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85696637
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82434084
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79925891
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.77287636
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.74782017
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.72898152
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.71586632
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.70241612
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70241612
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.67300624
24	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.65633512
25	EWS_26573619_Chip-Seq_HEK293_Human	1.65074231
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.64109591
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63791671
28	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.62665409
29	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.62058561
30	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.60870003
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60578938
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.57120846
33	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.54445471
34	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.54417210
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54018490
36	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.53850065
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.51337257
38	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.47723590
39	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.47723590
40	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.47325813
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.46892818
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46455286
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.45363801
44	P300_19829295_ChIP-Seq_ESCs_Human	1.42314913
45	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.41135149
46	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.38417236
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38388360
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38321091
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.36590448
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36034845
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.35930396
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35107045
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31826599
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31718590
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.25773554
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21813324
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21192472
58	MYC_19829295_ChIP-Seq_ESCs_Human	1.18087198
59	FUS_26573619_Chip-Seq_HEK293_Human	1.15222059
60	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.15033241
61	ERA_21632823_ChIP-Seq_H3396_Human	1.13544369
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13518191
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12567567
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09197428
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09197428
66	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.09181132
67	AR_25329375_ChIP-Seq_VCAP_Human	1.09167270
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07854156
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07854156
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.07612076
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06827060
72	ERG_20517297_ChIP-Seq_VCAP_Human	1.05820192
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05359026
74	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05207680
75	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.03844084
76	DROSHA_22980978_ChIP-Seq_HELA_Human	1.02971984
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02370798
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02001360
79	P53_21459846_ChIP-Seq_SAOS-2_Human	1.01512027
80	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.00586287
81	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00442054
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00395683
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00233718
84	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99888769
85	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99860076
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98755663
87	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98422387
88	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.97951125
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.96108769
90	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.95658663
91	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.95296219
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.94472795
93	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.94091378
94	NCOR_22424771_ChIP-Seq_293T_Human	0.92970031
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92506434
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.91878019
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91405007
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91342466
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.90842348
100	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89017429

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.19303068
2	MP0005646_abnormal_pituitary_gland	4.24884633
3	MP0003646_muscle_fatigue	4.04978178
4	MP0006292_abnormal_olfactory_placode	3.56128305
5	MP0003011_delayed_dark_adaptation	3.11639077
6	MP0002102_abnormal_ear_morphology	2.70094664
7	MP0002837_dystrophic_cardiac_calcinosis	2.65544098
8	MP0002938_white_spotting	2.19160387
9	MP0003880_abnormal_central_pattern	2.18423829
10	MP0005410_abnormal_fertilization	2.04194993
11	MP0008875_abnormal_xenobiotic_pharmacok	2.03748952
12	MP0010030_abnormal_orbit_morphology	1.89316711
13	MP0005423_abnormal_somatic_nervous	1.89274589
14	MP0001293_anophthalmia	1.65506774
15	MP0005377_hearing/vestibular/ear_phenot	1.60798932
16	MP0003878_abnormal_ear_physiology	1.60798932
17	MP0005645_abnormal_hypothalamus_physiol	1.60721899
18	MP0005551_abnormal_eye_electrophysiolog	1.59904030
19	MP0005379_endocrine/exocrine_gland_phen	1.59570573
20	MP0000631_abnormal_neuroendocrine_gland	1.56880262
21	MP0001968_abnormal_touch/_nociception	1.51945476
22	MP0000049_abnormal_middle_ear	1.51808157
23	MP0001348_abnormal_lacrimal_gland	1.51354132
24	MP0002928_abnormal_bile_duct	1.49218700
25	MP0003195_calcinosis	1.46889940
26	MP0008789_abnormal_olfactory_epithelium	1.38289757
27	MP0004885_abnormal_endolymph	1.35937211
28	MP0003283_abnormal_digestive_organ	1.32918623
29	MP0002272_abnormal_nervous_system	1.31606918
30	MP0008872_abnormal_physiological_respon	1.26328473
31	MP0001905_abnormal_dopamine_level	1.23659037
32	MP0003635_abnormal_synaptic_transmissio	1.23317243
33	MP0008877_abnormal_DNA_methylation	1.22798849
34	MP0002733_abnormal_thermal_nociception	1.22670022
35	MP0009745_abnormal_behavioral_response	1.20869516
36	MP0002736_abnormal_nociception_after	1.20854789
37	MP0006072_abnormal_retinal_apoptosis	1.15041826
38	MP0001485_abnormal_pinna_reflex	1.14890325
39	MP0009053_abnormal_anal_canal	1.13439730
40	MP0005389_reproductive_system_phenotype	1.13414398
41	MP0000778_abnormal_nervous_system	1.12668266
42	MP0001986_abnormal_taste_sensitivity	1.11645386
43	MP0006276_abnormal_autonomic_nervous	1.10385002
44	MP0002163_abnormal_gland_morphology	1.05645012
45	MP0002210_abnormal_sex_determination	1.05570720
46	MP0005248_abnormal_Harderian_gland	1.02781831
47	MP0008775_abnormal_heart_ventricle	1.02776761
48	MP0002876_abnormal_thyroid_physiology	1.01759214
49	MP0001970_abnormal_pain_threshold	1.01731496
50	MP0005253_abnormal_eye_physiology	1.01340311
51	MP0003698_abnormal_male_reproductive	1.00362257
52	MP0001765_abnormal_ion_homeostasis	0.99786916
53	MP0000230_abnormal_systemic_arterial	0.99410719
54	MP0005394_taste/olfaction_phenotype	0.98723532
55	MP0005499_abnormal_olfactory_system	0.98723532
56	MP0002184_abnormal_innervation	0.97950585
57	MP0002735_abnormal_chemical_nociception	0.97647758
58	MP0001440_abnormal_grooming_behavior	0.97376283
59	MP0002160_abnormal_reproductive_system	0.97216704
60	MP0004133_heterotaxia	0.96998603
61	MP0005083_abnormal_biliary_tract	0.95844658
62	MP0000026_abnormal_inner_ear	0.93477772
63	MP0003119_abnormal_digestive_system	0.92603516
64	MP0001929_abnormal_gametogenesis	0.92519143
65	MP0005085_abnormal_gallbladder_physiolo	0.92327997
66	MP0005195_abnormal_posterior_eye	0.91645469
67	MP0001486_abnormal_startle_reflex	0.90425512
68	MP0010386_abnormal_urinary_bladder	0.89899068
69	MP0003186_abnormal_redox_activity	0.89313831
70	MP0003567_abnormal_fetal_cardiomyocyte	0.89282865
71	MP0003122_maternal_imprinting	0.88780759
72	MP0000537_abnormal_urethra_morphology	0.88544582
73	MP0003315_abnormal_perineum_morphology	0.88207649
74	MP0001286_abnormal_eye_development	0.87758692
75	MP0003938_abnormal_ear_development	0.87056884
76	MP0002095_abnormal_skin_pigmentation	0.86769961
77	MP0001919_abnormal_reproductive_system	0.86420804
78	MP0002752_abnormal_somatic_nervous	0.86232221
79	MP0000372_irregular_coat_pigmentation	0.85416755
80	MP0001119_abnormal_female_reproductive	0.84566667
81	MP0004142_abnormal_muscle_tone	0.83946460
82	MP0002234_abnormal_pharynx_morphology	0.83813574
83	MP0002572_abnormal_emotion/affect_behav	0.83237670
84	MP0002063_abnormal_learning/memory/cond	0.82665625
85	MP0002277_abnormal_respiratory_mucosa	0.82631883
86	MP0002557_abnormal_social/conspecific_i	0.82423043
87	MP0005408_hypopigmentation	0.80278041
88	MP0004145_abnormal_muscle_electrophysio	0.79670898
89	MP0002734_abnormal_mechanical_nocicepti	0.78128960
90	MP0002282_abnormal_trachea_morphology	0.77627911
91	MP0005391_vision/eye_phenotype	0.76311879
92	MP0004084_abnormal_cardiac_muscle	0.76223360
93	MP0004043_abnormal_pH_regulation	0.75883454
94	MP0002064_seizures	0.74353759
95	MP0009278_abnormal_bone_marrow	0.74075102
96	MP0001529_abnormal_vocalization	0.74017643
97	MP0001346_abnormal_lacrimal_gland	0.73145272
98	MP0000653_abnormal_sex_gland	0.72565834
99	MP0009250_abnormal_appendicular_skeleto	0.70874374
100	MP0003937_abnormal_limbs/digits/tail_de	0.70407206

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	6.14850081
2	Reticulocytopenia (HP:0001896)	4.72522560
3	Abnormal rod and cone electroretinograms (HP:0008323)	4.62004360
4	Macrocytic anemia (HP:0001972)	3.99077315
5	Septo-optic dysplasia (HP:0100842)	3.89104258
6	Pancreatic fibrosis (HP:0100732)	3.75034828
7	True hermaphroditism (HP:0010459)	3.74565866
8	Decreased central vision (HP:0007663)	3.71483586
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.55647527
10	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.54697992
11	Pancreatic cysts (HP:0001737)	3.49232757
12	Pendular nystagmus (HP:0012043)	3.38357531
13	Nephronophthisis (HP:0000090)	3.32764520
14	Pallor (HP:0000980)	3.29660408
15	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.16952562
16	Stenosis of the external auditory canal (HP:0000402)	2.96185017
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.90360509
18	Absent/shortened dynein arms (HP:0200106)	2.90360509
19	Abnormal number of erythroid precursors (HP:0012131)	2.82687109
20	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.73907357
21	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.73525804
22	Acute necrotizing encephalopathy (HP:0006965)	2.63036909
23	Attenuation of retinal blood vessels (HP:0007843)	2.62512631
24	Abnormal respiratory motile cilium physiology (HP:0012261)	2.62502046
25	Adactyly (HP:0009776)	2.58894467
26	Abnormality of the renal medulla (HP:0100957)	2.57964051
27	Molar tooth sign on MRI (HP:0002419)	2.56993456
28	Abnormality of midbrain morphology (HP:0002418)	2.56993456
29	Increased hepatocellular lipid droplets (HP:0006565)	2.55446990
30	Maternal diabetes (HP:0009800)	2.53737066
31	Mitochondrial inheritance (HP:0001427)	2.51232954
32	Renal Fanconi syndrome (HP:0001994)	2.49495207
33	Keratoconus (HP:0000563)	2.48435879
34	Increased corneal curvature (HP:0100692)	2.48435879
35	Congenital stationary night blindness (HP:0007642)	2.47948897
36	Sclerocornea (HP:0000647)	2.45184016
37	Rib fusion (HP:0000902)	2.41992508
38	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.41274123
39	Absent septum pellucidum (HP:0001331)	2.41130608
40	Abolished electroretinogram (ERG) (HP:0000550)	2.36620995
41	Acute encephalopathy (HP:0006846)	2.35384463
42	Lipid accumulation in hepatocytes (HP:0006561)	2.33676031
43	Abnormality of macular pigmentation (HP:0008002)	2.32825408
44	Type II lissencephaly (HP:0007260)	2.32268978
45	Bony spicule pigmentary retinopathy (HP:0007737)	2.32028690
46	Abnormality of cochlea (HP:0000375)	2.27980031
47	Absent thumb (HP:0009777)	2.27805151
48	Congenital sensorineural hearing impairment (HP:0008527)	2.25392644
49	Abnormal mitochondria in muscle tissue (HP:0008316)	2.23217459
50	Cystic liver disease (HP:0006706)	2.21770288
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18206454
52	Anencephaly (HP:0002323)	2.16086595
53	Congenital hepatic fibrosis (HP:0002612)	2.15727359
54	Chronic bronchitis (HP:0004469)	2.15624216
55	Synostosis of carpal bones (HP:0005048)	2.14556488
56	Abnormal ciliary motility (HP:0012262)	2.13880757
57	Progressive macrocephaly (HP:0004481)	2.13258825
58	Asplenia (HP:0001746)	2.11709681
59	Male pseudohermaphroditism (HP:0000037)	2.11364903
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10599527
61	Postaxial foot polydactyly (HP:0001830)	2.06086787
62	Optic nerve hypoplasia (HP:0000609)	2.05974015
63	Dyschromatopsia (HP:0007641)	2.05699853
64	Depressed nasal ridge (HP:0000457)	2.03695820
65	Vitreoretinal degeneration (HP:0000655)	2.03158348
66	Abnormality of the renal collecting system (HP:0004742)	2.02552844
67	Pigmentary retinal degeneration (HP:0001146)	2.02062813
68	Morphological abnormality of the middle ear (HP:0008609)	2.01703403
69	Agitation (HP:0000713)	2.01489150
70	Methylmalonic acidemia (HP:0002912)	1.96409670
71	Cerebral edema (HP:0002181)	1.96178550
72	Medial flaring of the eyebrow (HP:0010747)	1.95079064
73	Growth hormone deficiency (HP:0000824)	1.93188832
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92304567
75	Severe visual impairment (HP:0001141)	1.91161681
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90281378
77	Hyperthyroidism (HP:0000836)	1.89841652
78	Increased CSF lactate (HP:0002490)	1.87943084
79	Abnormality of the septum pellucidum (HP:0007375)	1.86983874
80	Abnormality of renal resorption (HP:0011038)	1.84630991
81	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.83709087
82	Anophthalmia (HP:0000528)	1.83407151
83	Chronic hepatic failure (HP:0100626)	1.80525802
84	Tachypnea (HP:0002789)	1.80263861
85	Optic disc pallor (HP:0000543)	1.78089920
86	Abnormality of the nasal septum (HP:0000419)	1.77002394
87	Homocystinuria (HP:0002156)	1.75488382
88	Abnormality of homocysteine metabolism (HP:0010919)	1.75488382
89	Constricted visual fields (HP:0001133)	1.75443884
90	Methylmalonic aciduria (HP:0012120)	1.73431908
91	Hyperglycinemia (HP:0002154)	1.73292926
92	Abnormal hemoglobin (HP:0011902)	1.71773037
93	Morphological abnormality of the inner ear (HP:0011390)	1.71450523
94	Ketosis (HP:0001946)	1.70050687
95	Abnormality of the middle phalanges of the toes (HP:0010183)	1.69839117
96	Myokymia (HP:0002411)	1.68811576
97	Abnormality of the labia minora (HP:0012880)	1.67497281
98	Lethargy (HP:0001254)	1.67264734
99	Exertional dyspnea (HP:0002875)	1.66848096
100	3-Methylglutaconic aciduria (HP:0003535)	1.66782701

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.91793824
2	GRK1	3.37711880
3	PINK1	3.26513225
4	WNK4	3.10630480
5	PLK4	2.98622936
6	WNK3	2.93357624
7	ADRBK2	2.85519344
8	TNK2	2.45638592
9	MAP2K7	2.03837266
10	PAK3	1.85396693
11	CDK19	1.74493898
12	CAMK1	1.73552559
13	MAP3K11	1.73385081
14	BMPR1B	1.71393749
15	PAK6	1.69599194
16	PLK2	1.64104242
17	STK38L	1.62793879
18	TLK1	1.61720882
19	CAMK1G	1.58393309
20	PNCK	1.53380352
21	DYRK2	1.45194084
22	INSRR	1.44159159
23	FRK	1.33296858
24	EPHA4	1.30716255
25	RPS6KA4	1.27669168
26	DAPK2	1.25485748
27	NUAK1	1.21596270
28	CDC7	1.18932142
29	TXK	1.17728600
30	AURKA	1.17125805
31	CSNK1G2	1.15037008
32	CAMK1D	1.12217725
33	PRKG2	1.07571444
34	PTK6	1.06720670
35	PIK3CA	1.06323514
36	NTRK3	1.03057481
37	MAP4K2	0.99232105
38	TIE1	0.98915287
39	CDK3	0.98396734
40	NTRK2	0.94248584
41	TAOK3	0.92112117
42	PRKCQ	0.90899762
43	ERBB2	0.89961501
44	MAPK15	0.87536685
45	TYRO3	0.84330564
46	TEC	0.82644998
47	MAP3K12	0.81785906
48	CSNK1G3	0.79034531
49	ADRBK1	0.78454158
50	LRRK2	0.77472501
51	CAMK2A	0.77210930
52	ITK	0.73418010
53	OBSCN	0.72436591
54	BTK	0.72180950
55	MINK1	0.72177843
56	MAPK13	0.69914643
57	SIK3	0.69869336
58	PRKACA	0.69144110
59	RPS6KA5	0.66594318
60	PRKD3	0.66334986
61	CSNK1G1	0.64658884
62	PRKCG	0.62744689
63	STK39	0.62525302
64	PTK2B	0.61999725
65	WNK1	0.61455589
66	PLK1	0.60596999
67	CSNK1A1	0.60292723
68	PIK3CG	0.60088208
69	CAMK4	0.56943417
70	MAP3K4	0.56112051
71	IRAK4	0.53418442
72	CDK8	0.52836906
73	MARK3	0.51070581
74	CSNK2A2	0.49148394
75	SIK2	0.48992892
76	TGFBR1	0.47456188
77	RPS6KA6	0.47010249
78	VRK1	0.46967087
79	CAMKK2	0.45796682
80	MUSK	0.44696727
81	PRKCE	0.44336551
82	MARK1	0.44101783
83	MKNK2	0.43606196
84	SIK1	0.43443575
85	PRKCA	0.42349686
86	IGF1R	0.41609847
87	AKT3	0.40480318
88	OXSR1	0.40143930
89	NEK2	0.38515153
90	PRKCH	0.37660300
91	CSF1R	0.37537934
92	STK24	0.36642880
93	MYLK	0.35825367
94	EPHB2	0.35628825
95	PRKG1	0.35042891
96	ZAK	0.34809114
97	PRKACG	0.34516481
98	PRKCZ	0.32216024
99	CSNK2A1	0.32132494
100	ERBB3	0.31617404

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.50774146
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.98261272
3	Parkinsons disease_Homo sapiens_hsa05012	3.38985609
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.78477619
5	Alzheimers disease_Homo sapiens_hsa05010	2.38839329
6	Huntingtons disease_Homo sapiens_hsa05016	2.17607815
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15984579
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.02563567
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.97291614
10	Nicotine addiction_Homo sapiens_hsa05033	1.81225819
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.81005447
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79048429
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78068573
14	Caffeine metabolism_Homo sapiens_hsa00232	1.72062909
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70909344
16	Phototransduction_Homo sapiens_hsa04744	1.59160304
17	Olfactory transduction_Homo sapiens_hsa04740	1.50508179
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.50353428
19	One carbon pool by folate_Homo sapiens_hsa00670	1.44273816
20	RNA degradation_Homo sapiens_hsa03018	1.41217811
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30931007
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.29647343
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.19701048
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.14649770
25	Retinol metabolism_Homo sapiens_hsa00830	1.14412800
26	Circadian entrainment_Homo sapiens_hsa04713	1.13545680
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12736748
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12556090
29	Taste transduction_Homo sapiens_hsa04742	1.12184330
30	Basal cell carcinoma_Homo sapiens_hsa05217	1.11160828
31	Salivary secretion_Homo sapiens_hsa04970	1.10973848
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01151770
33	RNA polymerase_Homo sapiens_hsa03020	1.01066752
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00003589
35	Fat digestion and absorption_Homo sapiens_hsa04975	0.98326334
36	Sulfur relay system_Homo sapiens_hsa04122	0.96771373
37	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95326459
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95150357
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92712549
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91829836
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.89184813
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88923802
43	Homologous recombination_Homo sapiens_hsa03440	0.88531080
44	Propanoate metabolism_Homo sapiens_hsa00640	0.88487355
45	Serotonergic synapse_Homo sapiens_hsa04726	0.84519288
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84221104
47	Cocaine addiction_Homo sapiens_hsa05030	0.82401727
48	Insulin secretion_Homo sapiens_hsa04911	0.81587959
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80745183
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.80734313
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75788542
52	Morphine addiction_Homo sapiens_hsa05032	0.75147011
53	Fatty acid elongation_Homo sapiens_hsa00062	0.74772704
54	Protein export_Homo sapiens_hsa03060	0.74097324
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72887448
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72660401
57	Tyrosine metabolism_Homo sapiens_hsa00350	0.70223476
58	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.66936133
59	Peroxisome_Homo sapiens_hsa04146	0.65526979
60	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.64378620
61	Wnt signaling pathway_Homo sapiens_hsa04310	0.61567743
62	ABC transporters_Homo sapiens_hsa02010	0.60321709
63	Pancreatic secretion_Homo sapiens_hsa04972	0.59619429
64	cAMP signaling pathway_Homo sapiens_hsa04024	0.59313156
65	Mismatch repair_Homo sapiens_hsa03430	0.59258655
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58388286
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57839118
68	Asthma_Homo sapiens_hsa05310	0.57486297
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.56754923
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56032885
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.54277883
72	Melanoma_Homo sapiens_hsa05218	0.53584082
73	Renin secretion_Homo sapiens_hsa04924	0.53448831
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53071111
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52061862
76	Butanoate metabolism_Homo sapiens_hsa00650	0.51757568
77	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51722096
78	Long-term depression_Homo sapiens_hsa04730	0.51701532
79	Metabolic pathways_Homo sapiens_hsa01100	0.51658024
80	Amphetamine addiction_Homo sapiens_hsa05031	0.48699776
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45836092
82	Folate biosynthesis_Homo sapiens_hsa00790	0.45739445
83	Fanconi anemia pathway_Homo sapiens_hsa03460	0.45341514
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.44878539
85	GABAergic synapse_Homo sapiens_hsa04727	0.44395485
86	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44213899
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43044678
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41851142
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41778194
90	Ras signaling pathway_Homo sapiens_hsa04014	0.41624982
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.41503967
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40970762
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39821239
94	Allograft rejection_Homo sapiens_hsa05330	0.39482370
95	RNA transport_Homo sapiens_hsa03013	0.38850051
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35836328
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35601537
98	Long-term potentiation_Homo sapiens_hsa04720	0.33213601
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31236413
100	Bile secretion_Homo sapiens_hsa04976	0.31087020

RPL12P39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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