ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.11332734
2	regulation of female receptivity (GO:0045924)	5.99453435
3	translational termination (GO:0006415)	5.84660947
4	female mating behavior (GO:0060180)	5.34976188
5	translational elongation (GO:0006414)	5.06276437
6	water-soluble vitamin biosynthetic process (GO:0042364)	5.03158451
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.98945224
8	cotranslational protein targeting to membrane (GO:0006613)	4.95478515
9	negative regulation of T cell differentiation in thymus (GO:0033085)	4.93942580
10	response to xenobiotic stimulus (GO:0009410)	4.92343718
11	protein targeting to ER (GO:0045047)	4.87749552
12	ribosomal small subunit assembly (GO:0000028)	4.68458811
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.65551851
14	preassembly of GPI anchor in ER membrane (GO:0016254)	4.65056127
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.64714326
16	protein localization to endoplasmic reticulum (GO:0070972)	4.62557191
17	ribosomal small subunit biogenesis (GO:0042274)	4.52817724
18	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.44656540
19	chaperone-mediated protein transport (GO:0072321)	4.39527561
20	viral life cycle (GO:0019058)	4.36928204
21	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.27994358
22	cellular protein complex disassembly (GO:0043624)	4.23386775
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.21881403
24	regulation of immunoglobulin secretion (GO:0051023)	4.19896017
25	translational initiation (GO:0006413)	4.19861136
26	regulation of isotype switching to IgG isotypes (GO:0048302)	4.18270442
27	peptidyl-histidine modification (GO:0018202)	4.17332388
28	GTP biosynthetic process (GO:0006183)	4.16868139
29	behavioral response to nicotine (GO:0035095)	4.14468768
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.02051603
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.86228288
32	ATP synthesis coupled proton transport (GO:0015986)	3.86228288
33	DNA deamination (GO:0045006)	3.75797049
34	UTP biosynthetic process (GO:0006228)	3.74522255
35	positive regulation of protein homooligomerization (GO:0032464)	3.73779810
36	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.73696605
37	coenzyme catabolic process (GO:0009109)	3.69100819
38	protein neddylation (GO:0045116)	3.65894939
39	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.54752794
40	UTP metabolic process (GO:0046051)	3.53675296
41	cysteine metabolic process (GO:0006534)	3.52824059
42	translation (GO:0006412)	3.49731112
43	base-excision repair, AP site formation (GO:0006285)	3.47892719
44	protein complex biogenesis (GO:0070271)	3.46349537
45	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.43878596
46	protein complex disassembly (GO:0043241)	3.41250283
47	multicellular organism reproduction (GO:0032504)	3.39874725
48	ribosomal large subunit biogenesis (GO:0042273)	3.39369623
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.36026799
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.36026799
51	maturation of SSU-rRNA (GO:0030490)	3.35097992
52	cardiac left ventricle morphogenesis (GO:0003214)	3.33549342
53	positive regulation of T cell apoptotic process (GO:0070234)	3.32171846
54	positive regulation of isotype switching (GO:0045830)	3.28678748
55	pyrimidine nucleotide catabolic process (GO:0006244)	3.28074895
56	macromolecular complex disassembly (GO:0032984)	3.21698055
57	deoxyribonucleotide catabolic process (GO:0009264)	3.19737854
58	ribonucleoprotein complex biogenesis (GO:0022613)	3.13372765
59	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.13239870
60	cellular component biogenesis (GO:0044085)	3.12302036
61	protein targeting to membrane (GO:0006612)	3.11625315
62	maturation of 5.8S rRNA (GO:0000460)	3.10085321
63	cell proliferation in forebrain (GO:0021846)	3.08487257
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.07732705
65	NADH dehydrogenase complex assembly (GO:0010257)	3.07732705
66	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.07732705
67	rRNA processing (GO:0006364)	3.06883768
68	positive regulation of protein oligomerization (GO:0032461)	3.06071598
69	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05721910
70	positive regulation of DNA recombination (GO:0045911)	3.04330234
71	CTP biosynthetic process (GO:0006241)	3.03450875
72	CTP metabolic process (GO:0046036)	3.03450875
73	rRNA metabolic process (GO:0016072)	3.01054957
74	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	3.00961904
75	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.96302074
76	male meiosis I (GO:0007141)	2.93644445
77	deoxyribose phosphate catabolic process (GO:0046386)	2.91232748
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.88204800
79	C-terminal protein lipidation (GO:0006501)	2.83122020
80	rRNA transcription (GO:0009303)	2.82521411
81	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.79168696
82	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.78800404
83	nitric oxide mediated signal transduction (GO:0007263)	2.76029804
84	cofactor catabolic process (GO:0051187)	2.73288192
85	interferon-gamma production (GO:0032609)	2.72159365
86	negative regulation of macrophage differentiation (GO:0045650)	2.71116764
87	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.71005529
88	regulation of thymocyte apoptotic process (GO:0070243)	2.70602507
89	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.68826387
90	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.68222853
91	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.66879536
92	protein targeting to mitochondrion (GO:0006626)	2.65078602
93	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.64959331
94	C-terminal protein amino acid modification (GO:0018410)	2.64571514
95	regulation of regulatory T cell differentiation (GO:0045589)	2.63964264
96	positive regulation of fatty acid transport (GO:2000193)	2.63091473
97	positive regulation of prostaglandin secretion (GO:0032308)	2.62196032
98	replication fork processing (GO:0031297)	2.61615369
99	guanosine-containing compound biosynthetic process (GO:1901070)	2.61500430
100	mRNA catabolic process (GO:0006402)	2.61405818

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.36856937
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02783385
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99950159
4	IRF1_19129219_ChIP-ChIP_H3396_Human	2.81537215
5	VDR_22108803_ChIP-Seq_LS180_Human	2.78959895
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73052885
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.68528022
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.51501867
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.50044424
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.45905313
11	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.13597068
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.12110256
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.07063083
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.01134421
15	MYC_18940864_ChIP-ChIP_HL60_Human	1.98884988
16	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.91395902
17	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.91142422
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.88034559
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.87718943
20	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.86914386
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80945889
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76543033
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.74850802
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74108081
25	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.72633606
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69535922
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68496237
28	EWS_26573619_Chip-Seq_HEK293_Human	1.61338958
29	STAT1_20625510_ChIP-Seq_HELA_Human	1.58902678
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52087616
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.51305337
32	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.42295186
33	NANOG_20526341_ChIP-Seq_ESCs_Human	1.37651081
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35066039
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.34609541
36	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.32866161
37	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.31302011
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30307468
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29007154
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.28887191
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28876265
42	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.28435420
43	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.27939780
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.27679394
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.27219707
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.25569937
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.24468959
48	P300_19829295_ChIP-Seq_ESCs_Human	1.24348911
49	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.24286986
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.22965120
51	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.22597589
52	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22546441
53	NCOR_22424771_ChIP-Seq_293T_Human	1.21846312
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20839701
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20624733
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20624733
57	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.20091790
58	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.18761338
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18583854
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18583854
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.18541047
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18420784
63	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.18317553
64	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	1.18144142
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18032211
66	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17574250
67	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.16226377
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16051565
69	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.15750988
70	P53_21459846_ChIP-Seq_SAOS-2_Human	1.15457383
71	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.15433508
72	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.14846145
73	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13578326
74	AR_20517297_ChIP-Seq_VCAP_Human	1.13196176
75	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.13099340
76	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12761669
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.12505433
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12462413
79	RAC3_21632823_ChIP-Seq_H3396_Human	1.08839268
80	FUS_26573619_Chip-Seq_HEK293_Human	1.08231468
81	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07850805
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07119266
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05539568
84	ERA_21632823_ChIP-Seq_H3396_Human	1.04861230
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04383058
86	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03725498
87	GABP_19822575_ChIP-Seq_HepG2_Human	1.02687281
88	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.01611618
89	ER_23166858_ChIP-Seq_MCF-7_Human	1.01313730
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01179139
91	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00190013
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99513507
93	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99365565
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.99119832
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.98139252
96	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.97051303
97	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96824682
98	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96437529
99	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95739463
100	XRN2_22483619_ChIP-Seq_HELA_Human	0.94774131

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	5.03008925
2	MP0003646_muscle_fatigue	3.34033558
3	MP0005379_endocrine/exocrine_gland_phen	3.07187689
4	MP0009379_abnormal_foot_pigmentation	2.97759176
5	MP0006292_abnormal_olfactory_placode	2.94463904
6	MP0003011_delayed_dark_adaptation	2.49493144
7	MP0004885_abnormal_endolymph	2.41249285
8	MP0009780_abnormal_chondrocyte_physiolo	2.35416099
9	MP0002909_abnormal_adrenal_gland	2.24976921
10	MP0003879_abnormal_hair_cell	2.15408596
11	MP0002138_abnormal_hepatobiliary_system	2.12097713
12	MP0008789_abnormal_olfactory_epithelium	2.09091291
13	MP0003136_yellow_coat_color	1.99646003
14	MP0005670_abnormal_white_adipose	1.97944909
15	MP0001348_abnormal_lacrimal_gland	1.89983497
16	MP0001485_abnormal_pinna_reflex	1.86385230
17	MP0000372_irregular_coat_pigmentation	1.83816865
18	MP0002876_abnormal_thyroid_physiology	1.82712255
19	MP0004147_increased_porphyrin_level	1.81307794
20	MP0005410_abnormal_fertilization	1.72589611
21	MP0001835_abnormal_antigen_presentation	1.71494854
22	MP0003763_abnormal_thymus_physiology	1.65768244
23	MP0001919_abnormal_reproductive_system	1.61562739
24	MP0002736_abnormal_nociception_after	1.59771138
25	MP0005646_abnormal_pituitary_gland	1.57052573
26	MP0004742_abnormal_vestibular_system	1.54305335
27	MP0000631_abnormal_neuroendocrine_gland	1.53660356
28	MP0005551_abnormal_eye_electrophysiolog	1.51716693
29	MP0005645_abnormal_hypothalamus_physiol	1.51594597
30	MP0001968_abnormal_touch/_nociception	1.48668830
31	MP0008872_abnormal_physiological_respon	1.45731559
32	MP0005387_immune_system_phenotype	1.43440065
33	MP0001790_abnormal_immune_system	1.43440065
34	MP0001986_abnormal_taste_sensitivity	1.42817936
35	MP0005671_abnormal_response_to	1.39875089
36	MP0008775_abnormal_heart_ventricle	1.39011647
37	MP0001293_anophthalmia	1.36655100
38	MP0008875_abnormal_xenobiotic_pharmacok	1.36128188
39	MP0006276_abnormal_autonomic_nervous	1.35309947
40	MP0002938_white_spotting	1.34773978
41	MP0005394_taste/olfaction_phenotype	1.34012965
42	MP0005499_abnormal_olfactory_system	1.34012965
43	MP0005389_reproductive_system_phenotype	1.33770994
44	MP0003186_abnormal_redox_activity	1.33416416
45	MP0003786_premature_aging	1.32142154
46	MP0001873_stomach_inflammation	1.31124487
47	MP0004142_abnormal_muscle_tone	1.28777315
48	MP0009333_abnormal_splenocyte_physiolog	1.28391620
49	MP0005084_abnormal_gallbladder_morpholo	1.26838845
50	MP0003567_abnormal_fetal_cardiomyocyte	1.23979171
51	MP0000049_abnormal_middle_ear	1.21438148
52	MP0003195_calcinosis	1.19774868
53	MP0003787_abnormal_imprinting	1.18831447
54	MP0008877_abnormal_DNA_methylation	1.16400997
55	MP0003878_abnormal_ear_physiology	1.15054419
56	MP0005377_hearing/vestibular/ear_phenot	1.15054419
57	MP0005167_abnormal_blood-brain_barrier	1.14050796
58	MP0002653_abnormal_ependyma_morphology	1.13632023
59	MP0000685_abnormal_immune_system	1.13188696
60	MP0003122_maternal_imprinting	1.12773191
61	MP0003806_abnormal_nucleotide_metabolis	1.12666284
62	MP0003436_decreased_susceptibility_to	1.12082341
63	MP0006072_abnormal_retinal_apoptosis	1.10623824
64	MP0006036_abnormal_mitochondrial_physio	1.09558508
65	MP0004145_abnormal_muscle_electrophysio	1.09028182
66	MP0002160_abnormal_reproductive_system	1.07823482
67	MP0002272_abnormal_nervous_system	1.07231314
68	MP0002148_abnormal_hypersensitivity_rea	1.06338813
69	MP0003890_abnormal_embryonic-extraembry	1.06197364
70	MP0003123_paternal_imprinting	1.03506162
71	MP0003119_abnormal_digestive_system	1.03251610
72	MP0004036_abnormal_muscle_relaxation	0.99300896
73	MP0001188_hyperpigmentation	0.98909559
74	MP0002132_abnormal_respiratory_system	0.98741534
75	MP0009745_abnormal_behavioral_response	0.96566988
76	MP0005253_abnormal_eye_physiology	0.93716046
77	MP0002837_dystrophic_cardiac_calcinosis	0.91595678
78	MP0001663_abnormal_digestive_system	0.89986116
79	MP0000566_synostosis	0.89187478
80	MP0001905_abnormal_dopamine_level	0.87589985
81	MP0002693_abnormal_pancreas_physiology	0.87132117
82	MP0002822_catalepsy	0.84536602
83	MP0001727_abnormal_embryo_implantation	0.83485611
84	MP0005423_abnormal_somatic_nervous	0.83249464
85	MP0003633_abnormal_nervous_system	0.79990012
86	MP0001800_abnormal_humoral_immune	0.78930861
87	MP0005000_abnormal_immune_tolerance	0.78908152
88	MP0005083_abnormal_biliary_tract	0.78086035
89	MP0009046_muscle_twitch	0.77644546
90	MP0000470_abnormal_stomach_morphology	0.76718516
91	MP0001529_abnormal_vocalization	0.75732001
92	MP0002277_abnormal_respiratory_mucosa	0.75154229
93	MP0002933_joint_inflammation	0.73839872
94	MP0001502_abnormal_circadian_rhythm	0.73642517
95	MP0001963_abnormal_hearing_physiology	0.72506387
96	MP0002557_abnormal_social/conspecific_i	0.71780035
97	MP0004130_abnormal_muscle_cell	0.71734060
98	MP0005332_abnormal_amino_acid	0.71587556
99	MP0000427_abnormal_hair_cycle	0.71363351
100	MP0001486_abnormal_startle_reflex	0.70516506

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Lipid accumulation in hepatocytes (HP:0006561)	5.18742123
2	Absent/shortened dynein arms (HP:0200106)	4.18423995
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.18423995
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.84463105
5	Abnormal rod and cone electroretinograms (HP:0008323)	3.65823780
6	Colon cancer (HP:0003003)	3.54438410
7	Methylmalonic acidemia (HP:0002912)	3.53686629
8	Methylmalonic aciduria (HP:0012120)	3.51720509
9	Abnormal respiratory motile cilium morphology (HP:0005938)	3.45974118
10	Abnormal respiratory epithelium morphology (HP:0012253)	3.45974118
11	Increased hepatocellular lipid droplets (HP:0006565)	3.43978408
12	Hyperglycinemia (HP:0002154)	3.16909899
13	Reticulocytopenia (HP:0001896)	3.15052749
14	Increased muscle lipid content (HP:0009058)	3.13495227
15	Abnormal ciliary motility (HP:0012262)	3.12755294
16	Congenital stationary night blindness (HP:0007642)	3.02440823
17	Mitochondrial inheritance (HP:0001427)	2.97686343
18	Macrocytic anemia (HP:0001972)	2.93475743
19	Renal Fanconi syndrome (HP:0001994)	2.92596919
20	Abnormal biliary tract physiology (HP:0012439)	2.88814480
21	Bile duct proliferation (HP:0001408)	2.88814480
22	Respiratory difficulties (HP:0002880)	2.88557690
23	IgG deficiency (HP:0004315)	2.87128003
24	Polydipsia (HP:0001959)	2.81987319
25	Abnormal drinking behavior (HP:0030082)	2.81987319
26	Nephronophthisis (HP:0000090)	2.80121414
27	Acute necrotizing encephalopathy (HP:0006965)	2.79900600
28	Abnormal respiratory motile cilium physiology (HP:0012261)	2.75046212
29	Stomatitis (HP:0010280)	2.71697019
30	Increased CSF lactate (HP:0002490)	2.70432370
31	Decreased central vision (HP:0007663)	2.65742148
32	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.64531625
33	Dicarboxylic aciduria (HP:0003215)	2.64531625
34	Tubular atrophy (HP:0000092)	2.64265155
35	Submucous cleft hard palate (HP:0000176)	2.63807791
36	Acute encephalopathy (HP:0006846)	2.61053582
37	Enlarged kidneys (HP:0000105)	2.59118675
38	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.58462667
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.56564704
40	Abnormality of cells of the erythroid lineage (HP:0012130)	2.56402135
41	Panhypogammaglobulinemia (HP:0003139)	2.51463088
42	Attenuation of retinal blood vessels (HP:0007843)	2.46054883
43	Progressive macrocephaly (HP:0004481)	2.44332141
44	Increased IgM level (HP:0003496)	2.43469051
45	Esophageal neoplasm (HP:0100751)	2.42758854
46	Neoplasm of head and neck (HP:0012288)	2.42758854
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42022488
48	Severe visual impairment (HP:0001141)	2.38237020
49	Pallor (HP:0000980)	2.31463156
50	Polyuria (HP:0000103)	2.28704528
51	Asplenia (HP:0001746)	2.28232186
52	Congenital, generalized hypertrichosis (HP:0004540)	2.26490696
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24826701
54	Molar tooth sign on MRI (HP:0002419)	2.24726743
55	Abnormality of midbrain morphology (HP:0002418)	2.24726743
56	Chronic mucocutaneous candidiasis (HP:0002728)	2.22138208
57	Recurrent cutaneous fungal infections (HP:0011370)	2.22138208
58	Confusion (HP:0001289)	2.21476324
59	Pancreatic fibrosis (HP:0100732)	2.19717910
60	Hepatocellular necrosis (HP:0001404)	2.17502693
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16122720
62	Abnormality of the renal medulla (HP:0100957)	2.15847079
63	Abnormality of the renal cortex (HP:0011035)	2.14690946
64	Bony spicule pigmentary retinopathy (HP:0007737)	2.14066036
65	Concave nail (HP:0001598)	2.14019797
66	Agitation (HP:0000713)	2.13152216
67	Glycosuria (HP:0003076)	2.12814506
68	Abnormality of urine glucose concentration (HP:0011016)	2.12814506
69	Mutism (HP:0002300)	2.11052838
70	Abnormality of macular pigmentation (HP:0008002)	2.11040671
71	Adrenal hypoplasia (HP:0000835)	2.10958866
72	Abnormality of glycine metabolism (HP:0010895)	2.09387948
73	Abnormality of serine family amino acid metabolism (HP:0010894)	2.09387948
74	Exertional dyspnea (HP:0002875)	2.07991595
75	Abnormality of renal resorption (HP:0011038)	2.07595450
76	Absent thumb (HP:0009777)	2.02715627
77	Progressive inability to walk (HP:0002505)	2.02276025
78	Lethargy (HP:0001254)	2.00763587
79	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98661279
80	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98661279
81	Nephrogenic diabetes insipidus (HP:0009806)	1.98398175
82	Papilledema (HP:0001085)	1.98269317
83	Type II lissencephaly (HP:0007260)	1.97349156
84	True hermaphroditism (HP:0010459)	1.95775108
85	Respiratory distress (HP:0002098)	1.93430404
86	Elevated erythrocyte sedimentation rate (HP:0003565)	1.93145508
87	Renal cortical cysts (HP:0000803)	1.92822516
88	Sclerocornea (HP:0000647)	1.91390141
89	Neutropenia (HP:0001875)	1.90434146
90	Respiratory failure (HP:0002878)	1.89700939
91	Metabolic acidosis (HP:0001942)	1.89222538
92	Pancreatic cysts (HP:0001737)	1.89070137
93	Thyroid-stimulating hormone excess (HP:0002925)	1.88929490
94	Chronic sinusitis (HP:0011109)	1.88624836
95	Increased intramyocellular lipid droplets (HP:0012240)	1.88603234
96	Cerebral edema (HP:0002181)	1.87173420
97	Mesangial abnormality (HP:0001966)	1.86319091
98	Pendular nystagmus (HP:0012043)	1.85056563
99	Inability to walk (HP:0002540)	1.84647616
100	Lactic acidosis (HP:0003128)	1.83617890

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.39724820
2	ADRBK2	3.31512455
3	DYRK2	3.16660649
4	FRK	3.10371271
5	MST4	2.94826097
6	VRK2	2.89855092
7	TAF1	2.87536740
8	NEK1	2.52952841
9	ERN1	2.39875678
10	CDK19	2.37480677
11	NUAK1	2.32951110
12	TIE1	2.15273687
13	MAP4K2	2.04138773
14	STK39	1.95304473
15	WNK4	1.91962324
16	KIT	1.89295364
17	CSNK1A1L	1.79390518
18	GRK1	1.77274066
19	CSNK1G3	1.72140926
20	CSNK1G2	1.64633765
21	MAP2K2	1.59548617
22	DAPK2	1.55372923
23	EIF2AK3	1.54142863
24	EIF2AK1	1.42687732
25	IRAK2	1.37046143
26	CSNK1G1	1.36430725
27	PASK	1.32218423
28	STK11	1.31307652
29	PINK1	1.27934666
30	PIK3CA	1.25080749
31	TEC	1.24774359
32	VRK1	1.16053262
33	OXSR1	1.15449348
34	ZAK	1.14015674
35	IKBKE	1.12984441
36	ADRBK1	1.11985142
37	PDK2	1.10541385
38	INSRR	1.07532191
39	PAK3	1.03851866
40	LRRK2	1.03709346
41	BUB1	1.00896251
42	STK10	1.00506918
43	TSSK6	1.00411700
44	IKBKB	0.98387466
45	MAP4K1	0.97188921
46	MELK	0.96000836
47	BCR	0.90390929
48	NEK2	0.89079965
49	NLK	0.88473311
50	GRK5	0.86785990
51	BMPR1B	0.85181156
52	DAPK3	0.85083195
53	WNK3	0.79546634
54	STK16	0.77083494
55	TNIK	0.73218960
56	PRKCH	0.72186029
57	SMG1	0.70612820
58	NME1	0.70592891
59	MAP2K6	0.68202609
60	RPS6KA5	0.67453835
61	JAK3	0.67407276
62	MINK1	0.65456837
63	CAMKK2	0.64841502
64	EIF2AK2	0.64505076
65	DAPK1	0.64349462
66	PRKCQ	0.63775924
67	CSNK2A2	0.53469306
68	TBK1	0.51861073
69	PLK3	0.51656884
70	MAP3K8	0.49324290
71	PRKCG	0.49249582
72	STK4	0.49223893
73	PIK3CG	0.48754932
74	CHUK	0.48650735
75	HIPK2	0.47777821
76	AKT3	0.47426660
77	BCKDK	0.46302237
78	MAP2K1	0.46089528
79	ITK	0.43583996
80	MAP2K3	0.42957692
81	PLK4	0.42285380
82	PRKCA	0.41553459
83	ABL2	0.40914618
84	FLT3	0.39095762
85	CSNK1A1	0.38572366
86	MAP2K7	0.38540174
87	PLK1	0.38145170
88	TGFBR1	0.38044730
89	RPS6KA6	0.37894256
90	CSNK1E	0.37023764
91	SYK	0.36886463
92	PLK2	0.36314993
93	PRKACA	0.35535540
94	CSNK2A1	0.34019992
95	PRKCD	0.33104983
96	PRKACG	0.31798624
97	MATK	0.28836859
98	PRKG2	0.28583486
99	ACVR1B	0.27541110
100	PRKCI	0.26273150

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.94978520
2	Allograft rejection_Homo sapiens_hsa05330	3.28596397
3	Asthma_Homo sapiens_hsa05310	3.15801289
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.05599556
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.81090380
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62304233
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.51034235
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.48127465
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.45432661
10	Sulfur relay system_Homo sapiens_hsa04122	2.30962531
11	Parkinsons disease_Homo sapiens_hsa05012	2.28623043
12	Basal transcription factors_Homo sapiens_hsa03022	2.02226272
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.93395214
14	Proteasome_Homo sapiens_hsa03050	1.85904545
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.83512660
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.76054868
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.69321814
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68802039
19	Phototransduction_Homo sapiens_hsa04744	1.55373179
20	Huntingtons disease_Homo sapiens_hsa05016	1.53790674
21	Alzheimers disease_Homo sapiens_hsa05010	1.48274481
22	Protein export_Homo sapiens_hsa03060	1.46665593
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.40257687
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.38348879
25	RNA polymerase_Homo sapiens_hsa03020	1.36613851
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27739114
27	Fatty acid degradation_Homo sapiens_hsa00071	1.27570712
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26372274
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.23985562
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22781011
31	Propanoate metabolism_Homo sapiens_hsa00640	1.21846198
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21378453
33	Caffeine metabolism_Homo sapiens_hsa00232	1.18981645
34	Viral myocarditis_Homo sapiens_hsa05416	1.17257514
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.17170254
36	Olfactory transduction_Homo sapiens_hsa04740	1.14613497
37	Peroxisome_Homo sapiens_hsa04146	1.09947274
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08443212
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.04403950
40	RNA degradation_Homo sapiens_hsa03018	1.03767650
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00691875
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.00155036
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99248697
44	Fatty acid metabolism_Homo sapiens_hsa01212	0.98987977
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96260053
46	Sulfur metabolism_Homo sapiens_hsa00920	0.93879314
47	Morphine addiction_Homo sapiens_hsa05032	0.91469374
48	One carbon pool by folate_Homo sapiens_hsa00670	0.91344673
49	Regulation of autophagy_Homo sapiens_hsa04140	0.88598205
50	Homologous recombination_Homo sapiens_hsa03440	0.87680506
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81998110
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.78011805
53	Serotonergic synapse_Homo sapiens_hsa04726	0.77025770
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76783958
55	Nicotine addiction_Homo sapiens_hsa05033	0.76087481
56	Purine metabolism_Homo sapiens_hsa00230	0.74957988
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.73470708
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.73083977
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.72218811
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70795735
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.70014170
62	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.69745073
63	Retinol metabolism_Homo sapiens_hsa00830	0.69133013
64	Butanoate metabolism_Homo sapiens_hsa00650	0.68762233
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.67991392
66	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67621907
67	Circadian entrainment_Homo sapiens_hsa04713	0.66081916
68	GABAergic synapse_Homo sapiens_hsa04727	0.65770027
69	Base excision repair_Homo sapiens_hsa03410	0.65172949
70	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.63678793
71	p53 signaling pathway_Homo sapiens_hsa04115	0.63091754
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61447696
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.58423233
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.57463668
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55762812
76	Metabolic pathways_Homo sapiens_hsa01100	0.54099248
77	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53436531
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53349204
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51968321
80	RNA transport_Homo sapiens_hsa03013	0.51698350
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51111388
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49252535
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47456132
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46741829
85	Folate biosynthesis_Homo sapiens_hsa00790	0.46352463
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42039013
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41052658
88	Salivary secretion_Homo sapiens_hsa04970	0.40588577
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40272813
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.40175481
91	Glutathione metabolism_Homo sapiens_hsa00480	0.38966045
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38153364
93	Insulin secretion_Homo sapiens_hsa04911	0.37478411
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37388825
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.36227910
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.35189156
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.31861450
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27739630
99	Nitrogen metabolism_Homo sapiens_hsa00910	0.24127777
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23885358

RPL12P41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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