RPL12P42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.02322208
2ribosomal small subunit assembly (GO:0000028)6.98211879
3translational termination (GO:0006415)6.78691135
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.77715810
5DNA deamination (GO:0045006)6.70681511
6ATP synthesis coupled proton transport (GO:0015986)6.16864773
7energy coupled proton transport, down electrochemical gradient (GO:0015985)6.16864773
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.99906402
9cotranslational protein targeting to membrane (GO:0006613)5.93869393
10protein targeting to ER (GO:0045047)5.93572937
11ribosomal small subunit biogenesis (GO:0042274)5.84470027
12translational elongation (GO:0006414)5.83816396
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.68757082
14protein localization to endoplasmic reticulum (GO:0070972)5.56499065
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.51376314
16maturation of SSU-rRNA (GO:0030490)5.25070810
17cellular protein complex disassembly (GO:0043624)5.18692609
18viral life cycle (GO:0019058)5.16277781
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.99281373
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.91560150
21respiratory electron transport chain (GO:0022904)4.83852016
22electron transport chain (GO:0022900)4.81151284
23translational initiation (GO:0006413)4.77154426
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.50124498
25cytidine metabolic process (GO:0046087)4.35844195
26cytidine catabolic process (GO:0006216)4.35844195
27cytidine deamination (GO:0009972)4.35844195
28protein complex disassembly (GO:0043241)4.30291833
29protein neddylation (GO:0045116)4.29901869
30ribosomal large subunit biogenesis (GO:0042273)4.17241125
31translation (GO:0006412)4.15131037
32macromolecular complex disassembly (GO:0032984)4.08993044
33protein complex biogenesis (GO:0070271)3.98313050
34cytochrome complex assembly (GO:0017004)3.92287801
35protein targeting to membrane (GO:0006612)3.84452965
36proteasome assembly (GO:0043248)3.82743529
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.80888845
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70836020
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.66258090
40respiratory chain complex IV assembly (GO:0008535)3.63279081
41mitochondrial respiratory chain complex assembly (GO:0033108)3.55202241
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.51892736
43termination of RNA polymerase III transcription (GO:0006386)3.51892736
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48937696
45mRNA catabolic process (GO:0006402)3.45314508
46sequestering of actin monomers (GO:0042989)3.44059707
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42704357
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42704357
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.39377010
50ATP biosynthetic process (GO:0006754)3.38571762
51regulation of mitochondrial translation (GO:0070129)3.38553092
52chaperone-mediated protein transport (GO:0072321)3.38077056
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.36192591
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35987903
55purine deoxyribonucleotide catabolic process (GO:0009155)3.32869526
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31438078
57hydrogen ion transmembrane transport (GO:1902600)3.30407355
58ribonucleoprotein complex biogenesis (GO:0022613)3.29223245
59GTP biosynthetic process (GO:0006183)3.28658548
60cellular component biogenesis (GO:0044085)3.26366662
61water-soluble vitamin biosynthetic process (GO:0042364)3.25692795
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23269907
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.23269907
64NADH dehydrogenase complex assembly (GO:0010257)3.23269907
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23260047
66regulation of cellular amino acid metabolic process (GO:0006521)3.21025856
67RNA catabolic process (GO:0006401)3.20758736
68deoxyribonucleotide catabolic process (GO:0009264)3.13801551
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13136914
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13136914
71rRNA modification (GO:0000154)3.11982188
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10683952
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10683952
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10683952
75pseudouridine synthesis (GO:0001522)3.02650836
76negative regulation of ligase activity (GO:0051352)2.99026483
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99026483
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.97395914
79DNA damage response, detection of DNA damage (GO:0042769)2.96223511
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95134522
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.95134522
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94980223
83proton transport (GO:0015992)2.93749458
84deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.92131926
85purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.91875231
86deoxyribose phosphate catabolic process (GO:0046386)2.91832698
87signal transduction involved in cell cycle checkpoint (GO:0072395)2.89967750
88hydrogen transport (GO:0006818)2.87750329
89pyrimidine nucleotide catabolic process (GO:0006244)2.86021546
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82895853
91Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81560046
92UTP biosynthetic process (GO:0006228)2.79802219
93rRNA processing (GO:0006364)2.77287866
94behavioral response to nicotine (GO:0035095)2.76891764
95chromatin remodeling at centromere (GO:0031055)2.76477524
96negative regulation of telomere maintenance (GO:0032205)2.75592461
97rRNA metabolic process (GO:0016072)2.72229104
98intracellular protein transmembrane import (GO:0044743)2.70852011
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70284047
100positive regulation of protein homodimerization activity (GO:0090073)2.67068375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.48496627
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45444393
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.38730238
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.15452413
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.06471160
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26991140
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13072578
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.09260056
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71049430
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.68714844
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68587941
12VDR_22108803_ChIP-Seq_LS180_Human2.62176705
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58443305
14VDR_23849224_ChIP-Seq_CD4+_Human2.55554390
15FOXP3_21729870_ChIP-Seq_TREG_Human2.44326036
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43068138
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37523116
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29637456
19ELK1_19687146_ChIP-ChIP_HELA_Human2.12327983
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11458408
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07364164
22MYC_18940864_ChIP-ChIP_HL60_Human1.98903113
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97760539
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90939685
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.89657654
26EZH2_22144423_ChIP-Seq_EOC_Human1.89642044
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86968549
28TTF2_22483619_ChIP-Seq_HELA_Human1.77315577
29XRN2_22483619_ChIP-Seq_HELA_Human1.76405184
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72634488
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71805582
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71402779
33ZNF274_21170338_ChIP-Seq_K562_Hela1.67261010
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65337902
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64779979
36IGF1R_20145208_ChIP-Seq_DFB_Human1.64693118
37EWS_26573619_Chip-Seq_HEK293_Human1.63764895
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.62992546
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57284245
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55898350
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47280925
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.46267911
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40295805
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40037656
45DCP1A_22483619_ChIP-Seq_HELA_Human1.30152825
46TP53_22573176_ChIP-Seq_HFKS_Human1.28706027
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28480332
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28052098
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24595200
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24047268
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23889565
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22730370
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21841287
54E2F7_22180533_ChIP-Seq_HELA_Human1.21280695
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20764218
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20049176
57GABP_19822575_ChIP-Seq_HepG2_Human1.19095671
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.16560747
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.15556997
60FUS_26573619_Chip-Seq_HEK293_Human1.13988878
61ERG_20517297_ChIP-Seq_VCAP_Human1.13208364
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13125120
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.11981439
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11876637
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11209187
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10993374
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10849465
68NCOR_22424771_ChIP-Seq_293T_Human1.10537186
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07862696
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07429196
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04187582
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.04187582
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03275983
74TAF2_19829295_ChIP-Seq_ESCs_Human1.02967055
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02897102
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02880150
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02315637
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.02010341
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00352287
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99369172
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97511123
82AR_20517297_ChIP-Seq_VCAP_Human0.96534542
83SOX2_19829295_ChIP-Seq_ESCs_Human0.95763958
84NANOG_19829295_ChIP-Seq_ESCs_Human0.95763958
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.95642671
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95577313
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95173496
88NANOG_20526341_ChIP-Seq_ESCs_Human0.91687446
89ERA_21632823_ChIP-Seq_H3396_Human0.90934834
90MYC_19829295_ChIP-Seq_ESCs_Human0.90395499
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.90197757
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88909060
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87860973
94MYB_26560356_Chip-Seq_TH2_Human0.85784155
95HTT_18923047_ChIP-ChIP_STHdh_Human0.85555452
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84266730
97STAT1_20625510_ChIP-Seq_HELA_Human0.83981243
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83661343
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82431891
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79750452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.74631638
2MP0003283_abnormal_digestive_organ4.30200060
3MP0006292_abnormal_olfactory_placode3.19216896
4MP0002102_abnormal_ear_morphology2.95325708
5MP0005671_abnormal_response_to2.81222646
6MP0002736_abnormal_nociception_after2.12309344
7MP0001968_abnormal_touch/_nociception1.94211734
8MP0001835_abnormal_antigen_presentation1.86133885
9MP0001293_anophthalmia1.79737577
10MP0003136_yellow_coat_color1.76233693
11MP0002234_abnormal_pharynx_morphology1.75471058
12MP0002277_abnormal_respiratory_mucosa1.74446382
13MP0005084_abnormal_gallbladder_morpholo1.70241726
14MP0008058_abnormal_DNA_repair1.68420235
15MP0004145_abnormal_muscle_electrophysio1.66305512
16MP0005075_abnormal_melanosome_morpholog1.65149875
17MP0002938_white_spotting1.62858510
18MP0006072_abnormal_retinal_apoptosis1.62349865
19MP0001485_abnormal_pinna_reflex1.59326191
20MP0008872_abnormal_physiological_respon1.57364133
21MP0005646_abnormal_pituitary_gland1.52331730
22MP0003806_abnormal_nucleotide_metabolis1.52224963
23MP0002166_altered_tumor_susceptibility1.49789868
24MP0001905_abnormal_dopamine_level1.49653202
25MP0008789_abnormal_olfactory_epithelium1.48241743
26MP0009785_altered_susceptibility_to1.43303548
27MP0003786_premature_aging1.43101399
28MP0002837_dystrophic_cardiac_calcinosis1.40006226
29MP0008877_abnormal_DNA_methylation1.38406136
30MP0005551_abnormal_eye_electrophysiolog1.37042856
31MP0010094_abnormal_chromosome_stability1.36681203
32MP0005377_hearing/vestibular/ear_phenot1.36463891
33MP0003878_abnormal_ear_physiology1.36463891
34MP0001986_abnormal_taste_sensitivity1.34214395
35MP0003693_abnormal_embryo_hatching1.32134115
36MP0001919_abnormal_reproductive_system1.29581388
37MP0009333_abnormal_splenocyte_physiolog1.28497613
38MP0002006_tumorigenesis1.28470086
39MP0003718_maternal_effect1.27055776
40MP0001873_stomach_inflammation1.25130165
41MP0002160_abnormal_reproductive_system1.24781915
42MP0004142_abnormal_muscle_tone1.22603587
43MP0005389_reproductive_system_phenotype1.22438990
44MP0000372_irregular_coat_pigmentation1.21054490
45MP0002163_abnormal_gland_morphology1.20621433
46MP0006036_abnormal_mitochondrial_physio1.17745407
47MP0002638_abnormal_pupillary_reflex1.17438694
48MP0002138_abnormal_hepatobiliary_system1.13861761
49MP0004885_abnormal_endolymph1.13819445
50MP0003646_muscle_fatigue1.11583658
51MP0002733_abnormal_thermal_nociception1.11124414
52MP0002095_abnormal_skin_pigmentation1.10136944
53MP0001800_abnormal_humoral_immune1.10029797
54MP0004957_abnormal_blastocyst_morpholog1.09959488
55MP0008875_abnormal_xenobiotic_pharmacok1.08989386
56MP0000631_abnormal_neuroendocrine_gland1.08191803
57MP0006276_abnormal_autonomic_nervous1.06774888
58MP0003763_abnormal_thymus_physiology1.06505103
59MP0000049_abnormal_middle_ear1.05573629
60MP0005253_abnormal_eye_physiology1.01903437
61MP0004147_increased_porphyrin_level1.01411096
62MP0001764_abnormal_homeostasis1.01141808
63MP0002148_abnormal_hypersensitivity_rea1.00030937
64MP0010386_abnormal_urinary_bladder0.99951776
65MP0002210_abnormal_sex_determination0.99089122
66MP0005645_abnormal_hypothalamus_physiol0.98509827
67MP0003011_delayed_dark_adaptation0.98490388
68MP0002272_abnormal_nervous_system0.97399202
69MP0008995_early_reproductive_senescence0.97332891
70MP0005174_abnormal_tail_pigmentation0.92427482
71MP0003186_abnormal_redox_activity0.91632849
72MP0001790_abnormal_immune_system0.91495289
73MP0005387_immune_system_phenotype0.91495289
74MP0003195_calcinosis0.91238341
75MP0002693_abnormal_pancreas_physiology0.90640869
76MP0002420_abnormal_adaptive_immunity0.90459456
77MP0002735_abnormal_chemical_nociception0.89940798
78MP0003315_abnormal_perineum_morphology0.89180184
79MP0000613_abnormal_salivary_gland0.87567678
80MP0005025_abnormal_response_to0.86739115
81MP0001819_abnormal_immune_cell0.86172012
82MP0001929_abnormal_gametogenesis0.86159764
83MP0001529_abnormal_vocalization0.85902708
84MP0004742_abnormal_vestibular_system0.85440636
85MP0005410_abnormal_fertilization0.85152180
86MP0005499_abnormal_olfactory_system0.84319594
87MP0005394_taste/olfaction_phenotype0.84319594
88MP0001119_abnormal_female_reproductive0.83463326
89MP0001970_abnormal_pain_threshold0.83016146
90MP0003567_abnormal_fetal_cardiomyocyte0.81391672
91MP0005379_endocrine/exocrine_gland_phen0.80752305
92MP0002723_abnormal_immune_serum0.79003825
93MP0009745_abnormal_behavioral_response0.78212204
94MP0002653_abnormal_ependyma_morphology0.76727077
95MP0009697_abnormal_copulation0.76723676
96MP0000653_abnormal_sex_gland0.75064203
97MP0000685_abnormal_immune_system0.74900058
98MP0001145_abnormal_male_reproductive0.74229435
99MP0002398_abnormal_bone_marrow0.74035446
100MP0000026_abnormal_inner_ear0.72987851

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.34014560
2Mitochondrial inheritance (HP:0001427)4.88711277
3Increased hepatocellular lipid droplets (HP:0006565)4.88547524
4Abnormal mitochondria in muscle tissue (HP:0008316)4.73669351
5Reticulocytopenia (HP:0001896)4.66444002
6Lipid accumulation in hepatocytes (HP:0006561)4.51488215
7Progressive macrocephaly (HP:0004481)4.45820397
8Acute encephalopathy (HP:0006846)4.35344842
9Abnormality of cells of the erythroid lineage (HP:0012130)4.19547505
10Increased CSF lactate (HP:0002490)4.18729708
11Aplastic anemia (HP:0001915)4.13572493
12Abnormal number of erythroid precursors (HP:0012131)4.04057318
13Hepatocellular necrosis (HP:0001404)4.00643369
14Macrocytic anemia (HP:0001972)3.92337854
15Renal Fanconi syndrome (HP:0001994)3.85393794
163-Methylglutaconic aciduria (HP:0003535)3.77022487
17Hepatic necrosis (HP:0002605)3.67662212
18Cerebral edema (HP:0002181)3.48058460
19Increased intramyocellular lipid droplets (HP:0012240)3.44427425
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.29314907
21Colon cancer (HP:0003003)3.17010362
22Exertional dyspnea (HP:0002875)3.12390186
23Optic disc pallor (HP:0000543)3.02724941
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97924869
25Pallor (HP:0000980)2.96389114
26Increased muscle lipid content (HP:0009058)2.94617371
27Pancytopenia (HP:0001876)2.82451026
28Elevated erythrocyte sedimentation rate (HP:0003565)2.73187616
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70446858
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68692307
31Abnormality of renal resorption (HP:0011038)2.67708927
32Absent thumb (HP:0009777)2.64274181
33Pancreatic cysts (HP:0001737)2.63680177
34Congenital, generalized hypertrichosis (HP:0004540)2.63025842
35Septo-optic dysplasia (HP:0100842)2.59640128
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58207952
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58207952
38Abnormality of midbrain morphology (HP:0002418)2.49971558
39Molar tooth sign on MRI (HP:0002419)2.49971558
40Increased serum lactate (HP:0002151)2.48705444
41Lactic acidosis (HP:0003128)2.45724797
42Exercise intolerance (HP:0003546)2.40344987
43Pancreatic fibrosis (HP:0100732)2.39246724
44IgG deficiency (HP:0004315)2.39033030
45Abnormal rod and cone electroretinograms (HP:0008323)2.38291369
46True hermaphroditism (HP:0010459)2.37769164
47Attenuation of retinal blood vessels (HP:0007843)2.37424046
48Decreased central vision (HP:0007663)2.35938457
49Respiratory difficulties (HP:0002880)2.35403783
50Lethargy (HP:0001254)2.34962919
51Leukodystrophy (HP:0002415)2.34627608
52Respiratory failure (HP:0002878)2.33401614
53Congenital stationary night blindness (HP:0007642)2.26931478
54Pendular nystagmus (HP:0012043)2.26215295
55Abolished electroretinogram (ERG) (HP:0000550)2.25412130
56Testicular atrophy (HP:0000029)2.24280488
57Methylmalonic acidemia (HP:0002912)2.18120881
58Abnormality of urine glucose concentration (HP:0011016)2.17814335
59Glycosuria (HP:0003076)2.17814335
60Oral leukoplakia (HP:0002745)2.14473490
61Severe combined immunodeficiency (HP:0004430)2.14380533
62Nephronophthisis (HP:0000090)2.12781889
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11066053
64Dicarboxylic aciduria (HP:0003215)2.11066053
65Methylmalonic aciduria (HP:0012120)2.10770384
66B lymphocytopenia (HP:0010976)2.08482590
67Abnormality of B cell number (HP:0010975)2.06410559
68Increased IgM level (HP:0003496)2.06078626
69Sclerocornea (HP:0000647)2.04502080
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.04440548
71Generalized aminoaciduria (HP:0002909)2.03300961
72Hyperphosphaturia (HP:0003109)2.01573880
73Renal cortical cysts (HP:0000803)1.99587218
74Triphalangeal thumb (HP:0001199)1.96909224
75Abnormality of the renal cortex (HP:0011035)1.96668591
76Rib fusion (HP:0000902)1.94206195
77Meckel diverticulum (HP:0002245)1.94093416
78Abnormality of the labia minora (HP:0012880)1.91792550
79Severe visual impairment (HP:0001141)1.90360800
80Parakeratosis (HP:0001036)1.90316580
81Cellular immunodeficiency (HP:0005374)1.87737568
82Abnormality of the ileum (HP:0001549)1.87378874
83Maternal diabetes (HP:0009800)1.86857461
84Chronic hepatic failure (HP:0100626)1.85657115
85T lymphocytopenia (HP:0005403)1.85388281
86Hyperglycinemia (HP:0002154)1.82334770
87Abnormality of DNA repair (HP:0003254)1.78612232
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78582916
89Constricted visual fields (HP:0001133)1.75216594
90Keratoconus (HP:0000563)1.74204850
91Increased corneal curvature (HP:0100692)1.74204850
92Type I transferrin isoform profile (HP:0003642)1.73514452
93Abnormal albumin level (HP:0012116)1.73106527
94Hypoalbuminemia (HP:0003073)1.73106527
95Abnormality of the prostate (HP:0008775)1.70555904
96Thyroiditis (HP:0100646)1.69658456
97Hypothermia (HP:0002045)1.68332859
98Abnormality of T cell number (HP:0011839)1.68287250
99Bilateral microphthalmos (HP:0007633)1.64545984
100Abnormality of chromosome stability (HP:0003220)1.64461002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.49147185
2TXK3.69505857
3KDR3.27006266
4TAF12.84465146
5STK162.78320816
6VRK12.61559057
7TLK12.51537526
8CDC72.29091714
9NUAK12.26125734
10TESK22.23019307
11WNK42.09937922
12ADRBK22.09553879
13BCKDK2.00692524
14MAP3K121.82382205
15NME11.80382144
16DYRK21.79087135
17GRK11.77865562
18ZAK1.59955626
19BUB11.59643493
20PASK1.49994181
21STK391.43560266
22MAP4K11.40459908
23FRK1.36831211
24BMPR1B1.33770700
25MST41.30079146
26NME21.18133780
27CDK191.16226124
28ITK1.14246828
29KIT1.12122785
30TEC1.09364462
31FES1.08264754
32WNK31.00320548
33GRK71.00203983
34PLK30.96779579
35ADRBK10.94155539
36TAOK30.92085162
37OXSR10.91940891
38PIK3CG0.91502545
39TIE10.91167885
40TRIM280.86556790
41DAPK30.83662797
42SYK0.83636668
43EIF2AK10.82359971
44IKBKB0.79139696
45LIMK10.78576831
46MAPKAPK50.78198419
47INSRR0.77949570
48AURKA0.77835451
49DAPK10.76834744
50TESK10.75734957
51MAPK150.75057595
52MAPKAPK30.71487123
53NEK10.70522073
54MYLK0.69070212
55MAP2K70.68940129
56AURKB0.68845485
57PBK0.68576434
58CSNK1G30.68104948
59ATR0.67951420
60GRK50.67785528
61ACVR1B0.67722195
62PRKCG0.66972646
63MAP2K60.66578960
64PINK10.66160621
65CSNK2A20.65247006
66TNIK0.63973847
67CSNK1G10.61769887
68PRKCQ0.60789768
69PLK10.60623481
70SCYL20.58449426
71CSNK1G20.56778112
72CSNK2A10.56229510
73IKBKE0.55818798
74WEE10.54314530
75MUSK0.53601079
76LRRK20.53242921
77MAP3K110.52422056
78CAMKK20.52090879
79PNCK0.51501789
80PLK40.51096793
81PRKCH0.50609814
82BTK0.50317879
83RPS6KB20.49775141
84MAP3K40.49774540
85RPS6KA50.43318136
86PIM10.43054552
87CHEK20.42948662
88MAP4K20.42815871
89LYN0.42424977
90NEK20.42352213
91CLK10.42329455
92TGFBR10.41289137
93PRKACA0.39259338
94BRSK20.38219692
95EIF2AK30.37393237
96ILK0.37227137
97PRKCA0.36787230
98LCK0.35961900
99EPHB20.34598649
100CSNK1A10.32954732

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.94734625
2Oxidative phosphorylation_Homo sapiens_hsa001904.53316963
3Proteasome_Homo sapiens_hsa030504.19307930
4Parkinsons disease_Homo sapiens_hsa050123.87058099
5RNA polymerase_Homo sapiens_hsa030202.94168226
6Huntingtons disease_Homo sapiens_hsa050162.59867552
7Homologous recombination_Homo sapiens_hsa034402.52050787
8Primary immunodeficiency_Homo sapiens_hsa053402.46792334
9Alzheimers disease_Homo sapiens_hsa050102.46103749
10Protein export_Homo sapiens_hsa030602.44150007
11DNA replication_Homo sapiens_hsa030302.41308102
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.40767454
13Mismatch repair_Homo sapiens_hsa034302.11357898
14Cardiac muscle contraction_Homo sapiens_hsa042602.05565663
15Fanconi anemia pathway_Homo sapiens_hsa034601.69356296
16Pyrimidine metabolism_Homo sapiens_hsa002401.68389128
17Base excision repair_Homo sapiens_hsa034101.61555316
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59189908
19Phototransduction_Homo sapiens_hsa047441.57405089
20RNA degradation_Homo sapiens_hsa030181.54620606
21Nucleotide excision repair_Homo sapiens_hsa034201.53569930
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51780838
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49131990
24Non-homologous end-joining_Homo sapiens_hsa034501.33757763
25Purine metabolism_Homo sapiens_hsa002301.33506583
26One carbon pool by folate_Homo sapiens_hsa006701.27505557
27Linoleic acid metabolism_Homo sapiens_hsa005911.23320090
28Basal transcription factors_Homo sapiens_hsa030221.21079200
29Spliceosome_Homo sapiens_hsa030401.15498898
30Antigen processing and presentation_Homo sapiens_hsa046121.11939614
31Autoimmune thyroid disease_Homo sapiens_hsa053201.11323814
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09312133
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07142961
34Allograft rejection_Homo sapiens_hsa053301.02755723
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.02378570
36Hematopoietic cell lineage_Homo sapiens_hsa046401.01605467
37RNA transport_Homo sapiens_hsa030130.98838699
38Graft-versus-host disease_Homo sapiens_hsa053320.96221634
39Nitrogen metabolism_Homo sapiens_hsa009100.95793722
40Propanoate metabolism_Homo sapiens_hsa006400.93677869
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93000937
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.92203052
43Peroxisome_Homo sapiens_hsa041460.92177727
44Type I diabetes mellitus_Homo sapiens_hsa049400.91586863
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82326172
46Asthma_Homo sapiens_hsa053100.79388192
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75044519
48Butanoate metabolism_Homo sapiens_hsa006500.72751478
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68764453
50Glutathione metabolism_Homo sapiens_hsa004800.68315770
51Folate biosynthesis_Homo sapiens_hsa007900.66901638
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65562484
53Metabolic pathways_Homo sapiens_hsa011000.63773023
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61223634
55Rheumatoid arthritis_Homo sapiens_hsa053230.60383295
56Chemical carcinogenesis_Homo sapiens_hsa052040.58212276
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57434962
58Tryptophan metabolism_Homo sapiens_hsa003800.57117263
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55846535
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54138851
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53537635
62T cell receptor signaling pathway_Homo sapiens_hsa046600.51971536
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49615821
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.49011971
65Selenocompound metabolism_Homo sapiens_hsa004500.48356560
66Retinol metabolism_Homo sapiens_hsa008300.47922952
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47609566
68Olfactory transduction_Homo sapiens_hsa047400.43763581
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42572322
70Ether lipid metabolism_Homo sapiens_hsa005650.41438952
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.40948779
72Arachidonic acid metabolism_Homo sapiens_hsa005900.40864256
73Collecting duct acid secretion_Homo sapiens_hsa049660.40490193
74Taste transduction_Homo sapiens_hsa047420.40090516
75Hedgehog signaling pathway_Homo sapiens_hsa043400.39915602
76Basal cell carcinoma_Homo sapiens_hsa052170.38286451
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37887127
78Nicotine addiction_Homo sapiens_hsa050330.36797976
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36353371
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.35070859
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34527427
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33831036
83beta-Alanine metabolism_Homo sapiens_hsa004100.33205897
84Systemic lupus erythematosus_Homo sapiens_hsa053220.32544828
85Epstein-Barr virus infection_Homo sapiens_hsa051690.32515935
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32048109
87Vitamin digestion and absorption_Homo sapiens_hsa049770.31770309
88Pyruvate metabolism_Homo sapiens_hsa006200.31410796
89Caffeine metabolism_Homo sapiens_hsa002320.30997902
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.29035770
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28968353
92Measles_Homo sapiens_hsa051620.28013428
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26144619
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25715691
95Mineral absorption_Homo sapiens_hsa049780.24364366
96Fat digestion and absorption_Homo sapiens_hsa049750.24249345
97Serotonergic synapse_Homo sapiens_hsa047260.22569731
98Fatty acid degradation_Homo sapiens_hsa000710.21096779
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20851149
100Regulation of autophagy_Homo sapiens_hsa041400.19840311

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