ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	5.06159946
2	fucose catabolic process (GO:0019317)	5.00919504
3	L-fucose metabolic process (GO:0042354)	5.00919504
4	L-fucose catabolic process (GO:0042355)	5.00919504
5	nonmotile primary cilium assembly (GO:0035058)	4.67700065
6	monoubiquitinated protein deubiquitination (GO:0035520)	4.54622007
7	behavioral response to nicotine (GO:0035095)	4.41838209
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.28353293
9	NADH dehydrogenase complex assembly (GO:0010257)	4.28353293
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.28353293
11	ubiquinone metabolic process (GO:0006743)	4.28299719
12	ubiquinone biosynthetic process (GO:0006744)	4.27248589
13	preassembly of GPI anchor in ER membrane (GO:0016254)	4.23786740
14	tachykinin receptor signaling pathway (GO:0007217)	4.16748448
15	protein complex biogenesis (GO:0070271)	4.14483513
16	GPI anchor biosynthetic process (GO:0006506)	4.09216626
17	mitochondrial respiratory chain complex assembly (GO:0033108)	4.04673777
18	platelet dense granule organization (GO:0060155)	4.02849560
19	urinary tract smooth muscle contraction (GO:0014848)	4.01886455
20	GPI anchor metabolic process (GO:0006505)	3.97214479
21	negative regulation of heart rate (GO:0010459)	3.91709322
22	aldehyde catabolic process (GO:0046185)	3.82743278
23	regulation of cilium movement (GO:0003352)	3.79906425
24	response to pheromone (GO:0019236)	3.78873237
25	pyrimidine nucleobase catabolic process (GO:0006208)	3.73544966
26	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.72921692
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.72921692
28	ATP synthesis coupled proton transport (GO:0015986)	3.67281600
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.67281600
30	quinone biosynthetic process (GO:1901663)	3.66826336
31	regulation of action potential (GO:0098900)	3.66610604
32	mannosylation (GO:0097502)	3.61874788
33	drinking behavior (GO:0042756)	3.59157584
34	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.55048689
35	kidney morphogenesis (GO:0060993)	3.52396467
36	positive regulation of vascular permeability (GO:0043117)	3.50014472
37	aggressive behavior (GO:0002118)	3.41729444
38	cytochrome complex assembly (GO:0017004)	3.37785832
39	negative regulation of response to food (GO:0032096)	3.37060265
40	negative regulation of appetite (GO:0032099)	3.37060265
41	intraciliary transport (GO:0042073)	3.33425969
42	protein localization to cilium (GO:0061512)	3.31393722
43	respiratory chain complex IV assembly (GO:0008535)	3.31187288
44	base-excision repair, AP site formation (GO:0006285)	3.29685785
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.27121577
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.22163957
47	nucleobase catabolic process (GO:0046113)	3.21265362
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.18040548
49	protein-cofactor linkage (GO:0018065)	3.17758699
50	reflex (GO:0060004)	3.14647260
51	negative regulation of mast cell activation (GO:0033004)	3.13605526
52	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.13574841
53	isoprenoid biosynthetic process (GO:0008299)	3.09968217
54	piRNA metabolic process (GO:0034587)	3.08442236
55	protein neddylation (GO:0045116)	3.07235810
56	neuronal action potential propagation (GO:0019227)	3.05146762
57	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.05056071
58	C-terminal protein lipidation (GO:0006501)	2.98148084
59	V(D)J recombination (GO:0033151)	2.97483555
60	glycolipid biosynthetic process (GO:0009247)	2.91801751
61	resolution of meiotic recombination intermediates (GO:0000712)	2.90581968
62	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.90082827
63	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.85937934
64	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.85403627
65	protein prenylation (GO:0018342)	2.82372882
66	prenylation (GO:0097354)	2.82372882
67	indolalkylamine metabolic process (GO:0006586)	2.78764272
68	maturation of SSU-rRNA (GO:0030490)	2.78615252
69	cornea development in camera-type eye (GO:0061303)	2.76889424
70	cellular ketone body metabolic process (GO:0046950)	2.74565080
71	cilium morphogenesis (GO:0060271)	2.74425520
72	ribosomal small subunit assembly (GO:0000028)	2.73967821
73	respiratory tube development (GO:0030323)	2.67915360
74	DNA integration (GO:0015074)	2.67471626
75	C-terminal protein amino acid modification (GO:0018410)	2.67028001
76	response to auditory stimulus (GO:0010996)	2.65882540
77	dopamine transport (GO:0015872)	2.65279399
78	RNA destabilization (GO:0050779)	2.64515808
79	glyoxylate metabolic process (GO:0046487)	2.64196816
80	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63923345
81	primary amino compound metabolic process (GO:1901160)	2.62739800
82	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.58848531
83	positive regulation of digestive system process (GO:0060456)	2.58414909
84	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.55779344
85	detection of light stimulus involved in sensory perception (GO:0050962)	2.51092004
86	detection of light stimulus involved in visual perception (GO:0050908)	2.51092004
87	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.51053098
88	kynurenine metabolic process (GO:0070189)	2.49886907
89	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.49048302
90	protein polyglutamylation (GO:0018095)	2.47446143
91	ketone body metabolic process (GO:1902224)	2.47257938
92	response to redox state (GO:0051775)	2.46676875
93	cellular biogenic amine biosynthetic process (GO:0042401)	2.46238082
94	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.44245247
95	oogenesis (GO:0048477)	2.43817063
96	lactate metabolic process (GO:0006089)	2.43522086
97	ATP biosynthetic process (GO:0006754)	2.43432963
98	cilium organization (GO:0044782)	2.43407656
99	amine biosynthetic process (GO:0009309)	2.42272201
100	cellular response to leptin stimulus (GO:0044320)	2.40420810

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.77840657
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.60865653
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.89432262
4	VDR_22108803_ChIP-Seq_LS180_Human	2.75612109
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63853337
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.57594599
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56418443
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56380820
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.48511030
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.41380416
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.38268746
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.22228809
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09157863
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.05883669
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98131191
16	EWS_26573619_Chip-Seq_HEK293_Human	1.93864167
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.92518568
18	FUS_26573619_Chip-Seq_HEK293_Human	1.91478598
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.82980140
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.79487806
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79413865
22	P300_19829295_ChIP-Seq_ESCs_Human	1.73231710
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71373517
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70973188
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.69678117
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66136501
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.66020032
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65757064
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.65682779
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.59896860
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58788872
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53447271
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50668388
34	AR_25329375_ChIP-Seq_VCAP_Human	1.48246958
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43409724
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40036967
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40036967
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39756037
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35911506
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34920796
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33830446
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.31240904
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31183219
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27742356
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.27149251
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26996058
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.26996058
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26545877
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26130084
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25356913
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24546432
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24546432
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.23285504
54	NCOR_22424771_ChIP-Seq_293T_Human	1.22915422
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21341837
56	AR_20517297_ChIP-Seq_VCAP_Human	1.20218687
57	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.19861245
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16722839
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16226417
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.14314829
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12592459
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12177401
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12065719
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.10787490
65	FOXP3_21729870_ChIP-Seq_TREG_Human	1.10650923
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10353127
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10353127
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10157168
69	STAT3_23295773_ChIP-Seq_U87_Human	1.09514063
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09492715
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08936109
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08713277
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08266075
74	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07652563
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07288475
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06068142
77	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.06035170
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05761186
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04144241
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03959846
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03528399
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.02825109
83	BCAT_22108803_ChIP-Seq_LS180_Human	1.01925348
84	TCF4_23295773_ChIP-Seq_U87_Human	1.00252565
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00123276
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00105208
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99888321
88	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99788434
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99783576
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98714651
91	ERA_21632823_ChIP-Seq_H3396_Human	0.98507385
92	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97344031
93	JUN_21703547_ChIP-Seq_K562_Human	0.96600403
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95325872
95	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95227726
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94134792
97	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.93377272
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93092609
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92476011
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.91486194

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	4.76853693
2	MP0002736_abnormal_nociception_after	4.00485312
3	MP0001968_abnormal_touch/_nociception	3.15359752
4	MP0004147_increased_porphyrin_level	3.15286404
5	MP0008877_abnormal_DNA_methylation	2.94664828
6	MP0003646_muscle_fatigue	2.93202237
7	MP0006292_abnormal_olfactory_placode	2.77732488
8	MP0005670_abnormal_white_adipose	2.66461778
9	MP0002735_abnormal_chemical_nociception	2.55443739
10	MP0002102_abnormal_ear_morphology	2.53091321
11	MP0003136_yellow_coat_color	2.52977308
12	MP0008789_abnormal_olfactory_epithelium	2.25416037
13	MP0003195_calcinosis	2.19903478
14	MP0002653_abnormal_ependyma_morphology	2.17989211
15	MP0008872_abnormal_physiological_respon	2.03554355
16	MP0008058_abnormal_DNA_repair	2.00762255
17	MP0004885_abnormal_endolymph	1.99308654
18	MP0002638_abnormal_pupillary_reflex	1.96692380
19	MP0005394_taste/olfaction_phenotype	1.84538763
20	MP0005499_abnormal_olfactory_system	1.84538763
21	MP0002876_abnormal_thyroid_physiology	1.83104580
22	MP0002163_abnormal_gland_morphology	1.77629277
23	MP0005646_abnormal_pituitary_gland	1.70929364
24	MP0003787_abnormal_imprinting	1.69816307
25	MP0006276_abnormal_autonomic_nervous	1.62258039
26	MP0009278_abnormal_bone_marrow	1.59621539
27	MP0002938_white_spotting	1.58582031
28	MP0001986_abnormal_taste_sensitivity	1.55728360
29	MP0005551_abnormal_eye_electrophysiolog	1.54274846
30	MP0004142_abnormal_muscle_tone	1.53830583
31	MP0009745_abnormal_behavioral_response	1.53769935
32	MP0001984_abnormal_olfaction	1.53698146
33	MP0002272_abnormal_nervous_system	1.50226833
34	MP0000372_irregular_coat_pigmentation	1.49355760
35	MP0001486_abnormal_startle_reflex	1.46509473
36	MP0004133_heterotaxia	1.44312914
37	MP0010094_abnormal_chromosome_stability	1.43537727
38	MP0005386_behavior/neurological_phenoty	1.40976276
39	MP0004924_abnormal_behavior	1.40976276
40	MP0009046_muscle_twitch	1.38641040
41	MP0004742_abnormal_vestibular_system	1.38237309
42	MP0003880_abnormal_central_pattern	1.35313935
43	MP0008875_abnormal_xenobiotic_pharmacok	1.31183644
44	MP0002572_abnormal_emotion/affect_behav	1.30858419
45	MP0002095_abnormal_skin_pigmentation	1.26734731
46	MP0003121_genomic_imprinting	1.20729063
47	MP0004043_abnormal_pH_regulation	1.20483357
48	MP0001485_abnormal_pinna_reflex	1.20012640
49	MP0008057_abnormal_DNA_replication	1.19921171
50	MP0004145_abnormal_muscle_electrophysio	1.16971743
51	MP0002734_abnormal_mechanical_nocicepti	1.16151450
52	MP0005379_endocrine/exocrine_gland_phen	1.14734640
53	MP0001970_abnormal_pain_threshold	1.13235689
54	MP0006072_abnormal_retinal_apoptosis	1.12947233
55	MP0005253_abnormal_eye_physiology	1.12758592
56	MP0002132_abnormal_respiratory_system	1.10450562
57	MP0005195_abnormal_posterior_eye	1.08873888
58	MP0002837_dystrophic_cardiac_calcinosis	1.07660995
59	MP0010030_abnormal_orbit_morphology	1.05764238
60	MP0005084_abnormal_gallbladder_morpholo	1.05551476
61	MP0002234_abnormal_pharynx_morphology	1.04104746
62	MP0000026_abnormal_inner_ear	1.02184144
63	MP0001963_abnormal_hearing_physiology	1.01385930
64	MP0002277_abnormal_respiratory_mucosa	0.98978893
65	MP0000538_abnormal_urinary_bladder	0.98061912
66	MP0002064_seizures	0.97590839
67	MP0009379_abnormal_foot_pigmentation	0.96294923
68	MP0001905_abnormal_dopamine_level	0.94432997
69	MP0002557_abnormal_social/conspecific_i	0.94000580
70	MP0002928_abnormal_bile_duct	0.93966484
71	MP0002067_abnormal_sensory_capabilities	0.92474267
72	MP0000049_abnormal_middle_ear	0.91582867
73	MP0002751_abnormal_autonomic_nervous	0.91374852
74	MP0000427_abnormal_hair_cycle	0.89820891
75	MP0008775_abnormal_heart_ventricle	0.89322510
76	MP0005389_reproductive_system_phenotype	0.88853753
77	MP0000516_abnormal_urinary_system	0.88305161
78	MP0005367_renal/urinary_system_phenotyp	0.88305161
79	MP0003011_delayed_dark_adaptation	0.87644905
80	MP0003635_abnormal_synaptic_transmissio	0.82874738
81	MP0002160_abnormal_reproductive_system	0.81291499
82	MP0005410_abnormal_fertilization	0.78324666
83	MP0000778_abnormal_nervous_system	0.77120159
84	MP0003698_abnormal_male_reproductive	0.75648488
85	MP0003693_abnormal_embryo_hatching	0.74834839
86	MP0000647_abnormal_sebaceous_gland	0.74456210
87	MP0001346_abnormal_lacrimal_gland	0.74163806
88	MP0002210_abnormal_sex_determination	0.73858656
89	MP0001929_abnormal_gametogenesis	0.73309098
90	MP0001293_anophthalmia	0.73226691
91	MP0003718_maternal_effect	0.72500249
92	MP0002752_abnormal_somatic_nervous	0.70090994
93	MP0006035_abnormal_mitochondrial_morpho	0.69851864
94	MP0000653_abnormal_sex_gland	0.69016517
95	MP0004085_abnormal_heartbeat	0.68425136
96	MP0001879_abnormal_lymphatic_vessel	0.67621295
97	MP0005187_abnormal_penis_morphology	0.67156695
98	MP0000685_abnormal_immune_system	0.66320963
99	MP0002229_neurodegeneration	0.65960935
100	MP0002063_abnormal_learning/memory/cond	0.63810294

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoproteinemia (HP:0003075)	4.63163586
2	True hermaphroditism (HP:0010459)	4.59826169
3	B lymphocytopenia (HP:0010976)	4.44355152
4	Abnormality of B cell number (HP:0010975)	4.06152193
5	Molar tooth sign on MRI (HP:0002419)	4.04708428
6	Abnormality of midbrain morphology (HP:0002418)	4.04708428
7	Hypoplasia of the thymus (HP:0000778)	4.04001917
8	Thyroiditis (HP:0100646)	3.78626451
9	Pancreatic cysts (HP:0001737)	3.72674560
10	Severe combined immunodeficiency (HP:0004430)	3.69164238
11	Chronic hepatic failure (HP:0100626)	3.68325589
12	Decreased central vision (HP:0007663)	3.66097407
13	Pancreatic fibrosis (HP:0100732)	3.49306966
14	Nephronophthisis (HP:0000090)	3.40263988
15	Erythroderma (HP:0001019)	3.14177137
16	Type II lissencephaly (HP:0007260)	3.05360323
17	Panhypogammaglobulinemia (HP:0003139)	2.99784074
18	Hyperglycinemia (HP:0002154)	2.99426912
19	Abnormality of the renal medulla (HP:0100957)	2.92040995
20	Medial flaring of the eyebrow (HP:0010747)	2.87336080
21	Gait imbalance (HP:0002141)	2.77958541
22	Mitochondrial inheritance (HP:0001427)	2.77354983
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.73654453
24	Abnormal number of erythroid precursors (HP:0012131)	2.72511386
25	Combined immunodeficiency (HP:0005387)	2.67055356
26	Congenital primary aphakia (HP:0007707)	2.64270606
27	Increased CSF lactate (HP:0002490)	2.62760513
28	Acute necrotizing encephalopathy (HP:0006965)	2.61482412
29	IgG deficiency (HP:0004315)	2.59136798
30	Colon cancer (HP:0003003)	2.57298582
31	Cystic liver disease (HP:0006706)	2.52220481
32	Hepatocellular necrosis (HP:0001404)	2.51465694
33	Inability to walk (HP:0002540)	2.51356947
34	Confusion (HP:0001289)	2.49230976
35	Supernumerary spleens (HP:0009799)	2.45950951
36	Progressive macrocephaly (HP:0004481)	2.44142077
37	Mutism (HP:0002300)	2.43728464
38	Tubular atrophy (HP:0000092)	2.43213328
39	Bile duct proliferation (HP:0001408)	2.39294813
40	Abnormal biliary tract physiology (HP:0012439)	2.39294813
41	Nephrogenic diabetes insipidus (HP:0009806)	2.36172197
42	Lipid accumulation in hepatocytes (HP:0006561)	2.31423476
43	Methylmalonic acidemia (HP:0002912)	2.28492172
44	Concave nail (HP:0001598)	2.28187847
45	Male pseudohermaphroditism (HP:0000037)	2.25549544
46	Cerebellar dysplasia (HP:0007033)	2.24751370
47	Abnormality of the labia minora (HP:0012880)	2.24031148
48	Sclerocornea (HP:0000647)	2.21468805
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17662876
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.17644640
51	Anterior segment dysgenesis (HP:0007700)	2.16645561
52	Acute encephalopathy (HP:0006846)	2.16015027
53	Postaxial foot polydactyly (HP:0001830)	2.14654849
54	Increased hepatocellular lipid droplets (HP:0006565)	2.12676464
55	Anencephaly (HP:0002323)	2.12012146
56	Congenital stationary night blindness (HP:0007642)	2.11136171
57	Lissencephaly (HP:0001339)	2.07244783
58	Dyskinesia (HP:0100660)	2.06584223
59	Tubulointerstitial nephritis (HP:0001970)	2.03543271
60	Increased serum lactate (HP:0002151)	2.03471846
61	Methylmalonic aciduria (HP:0012120)	2.01073616
62	Hepatic necrosis (HP:0002605)	1.98033352
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97622661
64	Absent/shortened dynein arms (HP:0200106)	1.97622661
65	Abolished electroretinogram (ERG) (HP:0000550)	1.95937672
66	Retinal dysplasia (HP:0007973)	1.95264614
67	Abnormal rod and cone electroretinograms (HP:0008323)	1.89424604
68	Eosinophilia (HP:0001880)	1.88539857
69	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.87572326
70	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.87572326
71	Hypokalemic alkalosis (HP:0001949)	1.87552146
72	Abnormality of glycine metabolism (HP:0010895)	1.87259967
73	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87259967
74	Vaginal atresia (HP:0000148)	1.86706929
75	Attenuation of retinal blood vessels (HP:0007843)	1.85448139
76	Genetic anticipation (HP:0003743)	1.85329315
77	Limb dystonia (HP:0002451)	1.84540825
78	Stomach cancer (HP:0012126)	1.84102648
79	Abnormality of the pons (HP:0007361)	1.83811480
80	Morphological abnormality of the inner ear (HP:0011390)	1.83522979
81	Occipital encephalocele (HP:0002085)	1.82505348
82	Abnormal protein glycosylation (HP:0012346)	1.82396632
83	Abnormal glycosylation (HP:0012345)	1.82396632
84	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.82396632
85	Abnormal protein N-linked glycosylation (HP:0012347)	1.82396632
86	Genital tract atresia (HP:0001827)	1.82007673
87	Reticulocytopenia (HP:0001896)	1.81746217
88	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79884131
89	Congenital hepatic fibrosis (HP:0002612)	1.79089978
90	Abnormality of eosinophils (HP:0001879)	1.78088617
91	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77475161
92	Stenosis of the external auditory canal (HP:0000402)	1.75345350
93	Furrowed tongue (HP:0000221)	1.75274303
94	Metabolic alkalosis (HP:0200114)	1.75136064
95	Asplenia (HP:0001746)	1.74582545
96	Abnormal hemoglobin (HP:0011902)	1.74358317
97	Cerebral edema (HP:0002181)	1.74231743
98	Chronic sinusitis (HP:0011109)	1.73176587
99	Agitation (HP:0000713)	1.72720258
100	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71259109

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	3.54308448
2	ADRBK2	3.18343188
3	MAPK13	2.89406991
4	FRK	2.65274101
5	ERBB3	2.57977414
6	NUAK1	2.43733539
7	GRK1	2.29127586
8	WNK3	2.28560521
9	CSNK1G3	2.15466517
10	BCR	2.06274798
11	TAOK3	2.04701496
12	TXK	1.99285224
13	ZAK	1.95455803
14	TLK1	1.92742570
15	CAMKK2	1.90949027
16	CSNK1G2	1.89756740
17	CSNK1G1	1.87800215
18	CASK	1.76621533
19	WNK4	1.76345829
20	PINK1	1.76256827
21	EIF2AK3	1.71213541
22	CSNK1A1L	1.65734750
23	TRIM28	1.62531285
24	TNIK	1.62322744
25	PRKD3	1.57098975
26	PAK3	1.53332611
27	MKNK2	1.41237310
28	STK16	1.30225110
29	BCKDK	1.24143026
30	BMPR1B	1.18964485
31	MAP3K4	1.18153806
32	MARK1	1.16703167
33	DYRK2	1.14663880
34	EIF2AK1	1.14288743
35	EPHA4	1.10838447
36	BMPR2	1.09037050
37	PIK3CG	1.05638709
38	PIK3CA	1.04108455
39	STK39	1.04053003
40	MKNK1	1.03369879
41	VRK2	1.02478308
42	ADRBK1	1.00016411
43	PAK6	0.98317500
44	MAP2K7	0.97549234
45	GRK7	0.95612010
46	VRK1	0.95545972
47	SRPK1	0.94016679
48	PRKCG	0.93911727
49	INSRR	0.93035420
50	WNK1	0.88787894
51	STK11	0.86109034
52	PRKCE	0.85858037
53	CCNB1	0.84432906
54	DAPK2	0.83974164
55	BRSK2	0.80138254
56	RPS6KA5	0.70567231
57	SCYL2	0.70067544
58	ACVR1B	0.69740758
59	MAP4K2	0.66357124
60	AURKB	0.65422166
61	MYLK	0.63814986
62	PLK2	0.58929477
63	GRK6	0.58094242
64	MAPKAPK3	0.57120782
65	PHKG1	0.56723061
66	PHKG2	0.56723061
67	MAPK7	0.55209085
68	CAMK2A	0.55002579
69	ROCK1	0.53955172
70	PRKCH	0.52394237
71	CSNK1A1	0.52324187
72	PLK3	0.51344348
73	PKN1	0.49892548
74	TEC	0.49047229
75	CAMK1	0.48263807
76	PRKCQ	0.48251804
77	TNK2	0.47700042
78	PRKACA	0.47137401
79	CSNK2A1	0.47089307
80	MINK1	0.47031473
81	ABL1	0.46621272
82	DYRK3	0.45872715
83	IKBKB	0.43772119
84	SYK	0.43520391
85	TGFBR1	0.42322533
86	NTRK2	0.41539776
87	BRSK1	0.41027982
88	KDR	0.40864865
89	RAF1	0.40854729
90	OBSCN	0.39327217
91	PRKCZ	0.38871040
92	PLK4	0.37496042
93	RPS6KB1	0.37470134
94	OXSR1	0.37351459
95	PLK1	0.37338254
96	PRKCA	0.36740295
97	NLK	0.35308455
98	NME1	0.32828307
99	ERBB2	0.32807322
100	MAPKAPK5	0.32797830

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.75007635
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17689214
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.71480491
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.69910021
5	Butanoate metabolism_Homo sapiens_hsa00650	2.52191011
6	Homologous recombination_Homo sapiens_hsa03440	2.48865522
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.45791833
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.45172537
9	Parkinsons disease_Homo sapiens_hsa05012	2.38878609
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.34565462
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.32287984
12	RNA polymerase_Homo sapiens_hsa03020	1.95415280
13	Ribosome_Homo sapiens_hsa03010	1.90612641
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90416786
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.76861827
16	Nicotine addiction_Homo sapiens_hsa05033	1.76526237
17	Huntingtons disease_Homo sapiens_hsa05016	1.76074006
18	Proteasome_Homo sapiens_hsa03050	1.71977649
19	Base excision repair_Homo sapiens_hsa03410	1.69351357
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69319084
21	Protein export_Homo sapiens_hsa03060	1.68976864
22	Basal transcription factors_Homo sapiens_hsa03022	1.49368549
23	Phototransduction_Homo sapiens_hsa04744	1.48545776
24	Asthma_Homo sapiens_hsa05310	1.47984196
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47514587
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.45366380
27	RNA degradation_Homo sapiens_hsa03018	1.44796873
28	Alzheimers disease_Homo sapiens_hsa05010	1.43513642
29	Caffeine metabolism_Homo sapiens_hsa00232	1.40921995
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38881932
31	Olfactory transduction_Homo sapiens_hsa04740	1.37947621
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.37868502
33	Propanoate metabolism_Homo sapiens_hsa00640	1.35013679
34	Mismatch repair_Homo sapiens_hsa03430	1.33036381
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32357875
36	Peroxisome_Homo sapiens_hsa04146	1.23977846
37	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.20156223
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18326014
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17287730
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16539098
41	Taste transduction_Homo sapiens_hsa04742	1.15429321
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.14158370
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13136268
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.12280338
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.09331985
46	Sulfur relay system_Homo sapiens_hsa04122	1.07940049
47	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07476394
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05106512
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00532138
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98331523
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.97478345
52	Primary immunodeficiency_Homo sapiens_hsa05340	0.91611375
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.90594842
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88397417
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82194005
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81977217
57	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81627315
58	Metabolic pathways_Homo sapiens_hsa01100	0.81593253
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80153075
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.79486624
61	Morphine addiction_Homo sapiens_hsa05032	0.79146083
62	Retinol metabolism_Homo sapiens_hsa00830	0.78954755
63	Basal cell carcinoma_Homo sapiens_hsa05217	0.76060891
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73694327
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.71292730
66	One carbon pool by folate_Homo sapiens_hsa00670	0.71120953
67	ABC transporters_Homo sapiens_hsa02010	0.71024523
68	Fatty acid elongation_Homo sapiens_hsa00062	0.68297368
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68236346
70	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.61273240
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60300545
72	Fatty acid degradation_Homo sapiens_hsa00071	0.60267970
73	Purine metabolism_Homo sapiens_hsa00230	0.58928850
74	GABAergic synapse_Homo sapiens_hsa04727	0.58149128
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56574120
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56389128
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56212813
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.55611504
79	DNA replication_Homo sapiens_hsa03030	0.55502189
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.55493047
81	Regulation of autophagy_Homo sapiens_hsa04140	0.54452555
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53040618
83	RNA transport_Homo sapiens_hsa03013	0.52252270
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49639570
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49342811
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45476333
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44562528
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.44411351
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41356018
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40481418
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.40190884
92	Circadian entrainment_Homo sapiens_hsa04713	0.39590984
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38971609
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37316464
95	Serotonergic synapse_Homo sapiens_hsa04726	0.35151952
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35004534
97	Spliceosome_Homo sapiens_hsa03040	0.32456553
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32136556
99	Sulfur metabolism_Homo sapiens_hsa00920	0.29666068
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28714951

RPL12P44

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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