RPL12P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.58605490
2ATP synthesis coupled proton transport (GO:0015986)6.58605490
3ribosomal small subunit assembly (GO:0000028)6.45768020
4viral transcription (GO:0019083)6.42404525
5translational termination (GO:0006415)6.20502900
6ribosomal small subunit biogenesis (GO:0042274)6.14830254
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.89222030
8water-soluble vitamin biosynthetic process (GO:0042364)5.73532520
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.47298871
10cotranslational protein targeting to membrane (GO:0006613)5.38153513
11protein targeting to ER (GO:0045047)5.37859501
12translational elongation (GO:0006414)5.37523927
13GTP biosynthetic process (GO:0006183)5.28334124
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.26857389
15mitochondrial respiratory chain complex I assembly (GO:0032981)5.26857389
16NADH dehydrogenase complex assembly (GO:0010257)5.26857389
17chaperone-mediated protein transport (GO:0072321)5.25267248
18establishment of protein localization to endoplasmic reticulum (GO:0072599)5.21320948
19protein complex biogenesis (GO:0070271)5.01855456
20protein localization to endoplasmic reticulum (GO:0070972)5.01200640
21mitochondrial respiratory chain complex assembly (GO:0033108)4.87994453
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.87061375
23maturation of SSU-rRNA (GO:0030490)4.72299633
24viral life cycle (GO:0019058)4.63584837
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.52975487
26cellular protein complex disassembly (GO:0043624)4.51115716
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.46347841
28UTP biosynthetic process (GO:0006228)4.44482858
29translational initiation (GO:0006413)4.41278085
30respiratory electron transport chain (GO:0022904)4.31001107
31electron transport chain (GO:0022900)4.28348923
32purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.28270891
33purine nucleoside triphosphate biosynthetic process (GO:0009145)4.22949592
34response to xenobiotic stimulus (GO:0009410)4.09725408
35UTP metabolic process (GO:0046051)4.08691723
36behavioral response to nicotine (GO:0035095)4.03644393
37collecting duct development (GO:0072044)4.01768467
38ATP biosynthetic process (GO:0006754)3.96671975
39platelet dense granule organization (GO:0060155)3.91848120
40urate metabolic process (GO:0046415)3.90139050
41translation (GO:0006412)3.87913663
42ribosomal large subunit biogenesis (GO:0042273)3.73147563
43ribonucleoside triphosphate biosynthetic process (GO:0009201)3.64158194
44nonmotile primary cilium assembly (GO:0035058)3.60574231
45protein complex disassembly (GO:0043241)3.59340283
46response to pheromone (GO:0019236)3.55336637
47protein targeting to membrane (GO:0006612)3.52187693
48cellular component biogenesis (GO:0044085)3.50870194
49guanosine-containing compound biosynthetic process (GO:1901070)3.48497079
50protein neddylation (GO:0045116)3.47490089
51CTP metabolic process (GO:0046036)3.45944480
52CTP biosynthetic process (GO:0006241)3.45944480
53kidney morphogenesis (GO:0060993)3.42514122
54peptidyl-histidine modification (GO:0018202)3.37223133
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.35499687
56macromolecular complex disassembly (GO:0032984)3.33332858
57respiratory chain complex IV assembly (GO:0008535)3.31495908
58mRNA catabolic process (GO:0006402)3.25557963
59metanephric tubule development (GO:0072170)3.25485719
60metanephric nephron tubule development (GO:0072234)3.25485719
61pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.20883115
62nephron tubule morphogenesis (GO:0072078)3.19758003
63nephron epithelium morphogenesis (GO:0072088)3.19758003
64hydrogen ion transmembrane transport (GO:1902600)3.19378149
65cartilage morphogenesis (GO:0060536)3.16495358
66cullin deneddylation (GO:0010388)3.16336292
67nucleoside triphosphate biosynthetic process (GO:0009142)3.13236791
68nephron tubule development (GO:0072080)3.11934174
69mitochondrion morphogenesis (GO:0070584)3.11455049
70positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.10733421
71respiratory tube development (GO:0030323)3.10279641
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07839966
73pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07550174
74termination of RNA polymerase III transcription (GO:0006386)3.06790029
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.06790029
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04877877
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04877877
78negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01560818
79regulation of isotype switching to IgG isotypes (GO:0048302)3.00508516
80pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00379359
81pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.95517990
82nucleoside diphosphate phosphorylation (GO:0006165)2.94342356
83ribonucleoprotein complex biogenesis (GO:0022613)2.94233148
84RNA catabolic process (GO:0006401)2.94099162
85establishment of tissue polarity (GO:0007164)2.93663429
86establishment of planar polarity (GO:0001736)2.93663429
87cornea development in camera-type eye (GO:0061303)2.92828756
88lung epithelium development (GO:0060428)2.90055058
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88504260
90regulation of immunoglobulin secretion (GO:0051023)2.88138065
91intracellular protein transmembrane import (GO:0044743)2.87613090
92proton transport (GO:0015992)2.87125316
93renal tubule development (GO:0061326)2.85791284
94epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.84266287
95protein deneddylation (GO:0000338)2.84206261
96protein-cofactor linkage (GO:0018065)2.82373393
97cytochrome complex assembly (GO:0017004)2.79798725
98hydrogen transport (GO:0006818)2.79513267
99regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.78305977
100pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.76985831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.51764949
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.03069798
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.90717789
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.69985827
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55833618
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.45830548
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36952382
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01014547
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87536084
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.81220259
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78676376
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64071998
13VDR_22108803_ChIP-Seq_LS180_Human2.36184828
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19298354
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.09387793
16ZNF274_21170338_ChIP-Seq_K562_Hela1.99569529
17EWS_26573619_Chip-Seq_HEK293_Human1.99484767
18VDR_23849224_ChIP-Seq_CD4+_Human1.94505212
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93220413
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90098387
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.86204177
22TTF2_22483619_ChIP-Seq_HELA_Human1.86039134
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85353108
24MYC_18940864_ChIP-ChIP_HL60_Human1.80723134
25FOXP3_21729870_ChIP-Seq_TREG_Human1.70928803
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69957106
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64499586
28ELK1_19687146_ChIP-ChIP_HELA_Human1.63973404
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62766713
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59676317
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.58361891
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57299251
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56483214
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55434799
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54317293
36XRN2_22483619_ChIP-Seq_HELA_Human1.54022312
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51044125
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48764428
39TP53_22573176_ChIP-Seq_HFKS_Human1.45998533
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43310018
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.42695503
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40161434
43LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34154036
44FUS_26573619_Chip-Seq_HEK293_Human1.33957927
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29057103
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.29057103
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28376202
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26273429
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25886289
50RNF2_27304074_Chip-Seq_NSC_Mouse1.25864764
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.25461818
52P300_19829295_ChIP-Seq_ESCs_Human1.19959895
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19190135
54ERA_21632823_ChIP-Seq_H3396_Human1.18335343
55GABP_19822575_ChIP-Seq_HepG2_Human1.15032642
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13903582
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13665543
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.13653639
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13138932
60DCP1A_22483619_ChIP-Seq_HELA_Human1.12241602
61NANOG_20526341_ChIP-Seq_ESCs_Human1.11445223
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11408146
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10581885
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09914251
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09698159
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09588139
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.08444947
68TAF15_26573619_Chip-Seq_HEK293_Human1.08145628
69MYC_19829295_ChIP-Seq_ESCs_Human1.07279592
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07164571
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.06365606
72NANOG_19829295_ChIP-Seq_ESCs_Human1.06144263
73SOX2_19829295_ChIP-Seq_ESCs_Human1.06144263
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.03861481
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02549757
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01426107
77P53_21459846_ChIP-Seq_SAOS-2_Human1.00634122
78E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98391184
79AR_20517297_ChIP-Seq_VCAP_Human0.98240125
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97035364
81CBP_20019798_ChIP-Seq_JUKART_Human0.96495458
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96495458
83JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96380833
84TAF2_19829295_ChIP-Seq_ESCs_Human0.94268370
85IRF1_19129219_ChIP-ChIP_H3396_Human0.93828405
86NCOR_22424771_ChIP-Seq_293T_Human0.93790536
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.92778218
88EZH2_27294783_Chip-Seq_ESCs_Mouse0.92314946
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89259168
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88545411
91EED_16625203_ChIP-ChIP_MESCs_Mouse0.88378870
92HOXB7_26014856_ChIP-Seq_BT474_Human0.86216703
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86064167
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84836131
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84656322
96REST_21632747_ChIP-Seq_MESCs_Mouse0.83787765
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83693820
98PHF8_20622853_ChIP-Seq_HELA_Human0.80908368
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79821592
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79453555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.40440742
2MP0005646_abnormal_pituitary_gland3.95555188
3MP0002163_abnormal_gland_morphology3.84623229
4MP0002102_abnormal_ear_morphology3.49509266
5MP0003195_calcinosis2.91753907
6MP0005379_endocrine/exocrine_gland_phen2.87463109
7MP0000372_irregular_coat_pigmentation2.86820808
8MP0003283_abnormal_digestive_organ2.66829217
9MP0008877_abnormal_DNA_methylation2.59563174
10MP0006292_abnormal_olfactory_placode2.40832856
11MP0001485_abnormal_pinna_reflex2.37883562
12MP0006072_abnormal_retinal_apoptosis2.27543047
13MP0002653_abnormal_ependyma_morphology2.17953727
14MP0003011_delayed_dark_adaptation1.93857875
15MP0003786_premature_aging1.93329365
16MP0002938_white_spotting1.81878129
17MP0003878_abnormal_ear_physiology1.79954890
18MP0005377_hearing/vestibular/ear_phenot1.79954890
19MP0001986_abnormal_taste_sensitivity1.77873586
20MP0002837_dystrophic_cardiac_calcinosis1.77687364
21MP0005084_abnormal_gallbladder_morpholo1.72850633
22MP0008872_abnormal_physiological_respon1.72087323
23MP0002277_abnormal_respiratory_mucosa1.65024252
24MP0008789_abnormal_olfactory_epithelium1.64750954
25MP0005551_abnormal_eye_electrophysiolog1.64501500
26MP0003186_abnormal_redox_activity1.61262301
27MP0003787_abnormal_imprinting1.60218092
28MP0003136_yellow_coat_color1.59912008
29MP0004885_abnormal_endolymph1.56888284
30MP0010030_abnormal_orbit_morphology1.56661336
31MP0001346_abnormal_lacrimal_gland1.55034811
32MP0000049_abnormal_middle_ear1.49835633
33MP0009384_cardiac_valve_regurgitation1.49136845
34MP0005645_abnormal_hypothalamus_physiol1.48894705
35MP0008875_abnormal_xenobiotic_pharmacok1.48213274
36MP0008995_early_reproductive_senescence1.47279777
37MP0008775_abnormal_heart_ventricle1.41492829
38MP0003693_abnormal_embryo_hatching1.41111440
39MP0002272_abnormal_nervous_system1.40459651
40MP0004142_abnormal_muscle_tone1.35583843
41MP0001984_abnormal_olfaction1.33667186
42MP0003646_muscle_fatigue1.30210967
43MP0002876_abnormal_thyroid_physiology1.27601782
44MP0001529_abnormal_vocalization1.25677070
45MP0002095_abnormal_skin_pigmentation1.23956701
46MP0002160_abnormal_reproductive_system1.23030582
47MP0002638_abnormal_pupillary_reflex1.18703226
48MP0009745_abnormal_behavioral_response1.15345284
49MP0005499_abnormal_olfactory_system1.14998064
50MP0005394_taste/olfaction_phenotype1.14998064
51MP0006036_abnormal_mitochondrial_physio1.14647932
52MP0003942_abnormal_urinary_system1.13122537
53MP0003938_abnormal_ear_development1.12815503
54MP0001905_abnormal_dopamine_level1.12547014
55MP0000631_abnormal_neuroendocrine_gland1.12484280
56MP0000026_abnormal_inner_ear1.11602836
57MP0003123_paternal_imprinting1.10234881
58MP0003119_abnormal_digestive_system1.10117040
59MP0001293_anophthalmia1.08904529
60MP0005253_abnormal_eye_physiology1.08142911
61MP0005389_reproductive_system_phenotype1.02126285
62MP0009053_abnormal_anal_canal0.99835993
63MP0006035_abnormal_mitochondrial_morpho0.95638153
64MP0001968_abnormal_touch/_nociception0.94521013
65MP0009046_muscle_twitch0.94076567
66MP0002234_abnormal_pharynx_morphology0.92036285
67MP0002295_abnormal_pulmonary_circulatio0.90047358
68MP0004742_abnormal_vestibular_system0.89700310
69MP0005636_abnormal_mineral_homeostasis0.88863771
70MP0005410_abnormal_fertilization0.87275434
71MP0005195_abnormal_posterior_eye0.86418910
72MP0010386_abnormal_urinary_bladder0.86392592
73MP0005332_abnormal_amino_acid0.85577626
74MP0001486_abnormal_startle_reflex0.85428545
75MP0009780_abnormal_chondrocyte_physiolo0.81752882
76MP0001502_abnormal_circadian_rhythm0.80905510
77MP0002736_abnormal_nociception_after0.80113025
78MP0002928_abnormal_bile_duct0.78473922
79MP0008058_abnormal_DNA_repair0.77095698
80MP0002210_abnormal_sex_determination0.75132950
81MP0002064_seizures0.73454870
82MP0001963_abnormal_hearing_physiology0.73318737
83MP0004145_abnormal_muscle_electrophysio0.73186849
84MP0005360_urolithiasis0.72385040
85MP0009643_abnormal_urine_homeostasis0.72359882
86MP0001119_abnormal_female_reproductive0.70932955
87MP0003936_abnormal_reproductive_system0.70784581
88MP0001501_abnormal_sleep_pattern0.70610894
89MP0001765_abnormal_ion_homeostasis0.70547721
90MP0005423_abnormal_somatic_nervous0.69319644
91MP0002572_abnormal_emotion/affect_behav0.67679238
92MP0003567_abnormal_fetal_cardiomyocyte0.67086556
93MP0002557_abnormal_social/conspecific_i0.66498856
94MP0001145_abnormal_male_reproductive0.65775705
95MP0000230_abnormal_systemic_arterial0.64458720
96MP0001440_abnormal_grooming_behavior0.64245625
97MP0001727_abnormal_embryo_implantation0.63479854
98MP0009764_decreased_sensitivity_to0.63380496
99MP0000653_abnormal_sex_gland0.63094957
100MP0005391_vision/eye_phenotype0.62983231

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.00680318
2Progressive macrocephaly (HP:0004481)4.38778456
3Mitochondrial inheritance (HP:0001427)4.38087741
4Abnormal mitochondria in muscle tissue (HP:0008316)4.35505909
5Increased CSF lactate (HP:0002490)4.09709987
6Acute encephalopathy (HP:0006846)4.00548686
7Hepatocellular necrosis (HP:0001404)3.78866562
8Hepatic necrosis (HP:0002605)3.70977118
9Septo-optic dysplasia (HP:0100842)3.56834273
10Reticulocytopenia (HP:0001896)3.56187814
11Congenital stationary night blindness (HP:0007642)3.49482908
12Methylmalonic acidemia (HP:0002912)3.46606070
13Macrocytic anemia (HP:0001972)3.43025148
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.32938432
15Cerebral edema (HP:0002181)3.18579393
16Abnormality of cells of the erythroid lineage (HP:0012130)3.10539534
173-Methylglutaconic aciduria (HP:0003535)3.03860603
18Pendular nystagmus (HP:0012043)2.99646133
19Abnormal rod and cone electroretinograms (HP:0008323)2.96975753
20Increased hepatocellular lipid droplets (HP:0006565)2.94151891
21Hyperglycinemia (HP:0002154)2.91352997
22Increased serum lactate (HP:0002151)2.85320541
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75193553
24Methylmalonic aciduria (HP:0012120)2.72767716
25Decreased central vision (HP:0007663)2.70547168
26Lactic acidosis (HP:0003128)2.66233185
27Lipid accumulation in hepatocytes (HP:0006561)2.59429886
28Abolished electroretinogram (ERG) (HP:0000550)2.54825012
29Exertional dyspnea (HP:0002875)2.52844340
30Optic disc pallor (HP:0000543)2.51306865
31Abnormality of purine metabolism (HP:0004352)2.49384996
32Abnormal number of erythroid precursors (HP:0012131)2.46953987
33Renal Fanconi syndrome (HP:0001994)2.45904229
34True hermaphroditism (HP:0010459)2.45389485
35Dyschromatopsia (HP:0007641)2.45367967
36Abnormality of the vitamin B12 metabolism (HP:0004341)2.45221169
37Abnormality of vitamin B metabolism (HP:0004340)2.42129400
38Respiratory failure (HP:0002878)2.40893305
39Large for gestational age (HP:0001520)2.38987527
40Lethargy (HP:0001254)2.35780100
41Pancreatic fibrosis (HP:0100732)2.32028264
42Nephronophthisis (HP:0000090)2.30986741
43Pallor (HP:0000980)2.29738066
44Leukodystrophy (HP:0002415)2.26564354
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24147476
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24147476
47Dicarboxylic aciduria (HP:0003215)2.22850948
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22850948
49Abnormality of midbrain morphology (HP:0002418)2.22621188
50Molar tooth sign on MRI (HP:0002419)2.22621188
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.22048502
52Absent/shortened dynein arms (HP:0200106)2.22048502
53Hypoplasia of the ulna (HP:0003022)2.20070334
54Stenosis of the external auditory canal (HP:0000402)2.17220598
55Abnormality of the phalanges of the 5th finger (HP:0004213)2.16391340
56Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.15815582
57Renal cortical cysts (HP:0000803)2.12635506
58Asplenia (HP:0001746)2.11604605
59Stomatitis (HP:0010280)2.11299045
60Agitation (HP:0000713)2.08894362
61Medial flaring of the eyebrow (HP:0010747)2.07704132
62Nausea (HP:0002018)2.05499557
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.05072335
64Pancreatic cysts (HP:0001737)2.05039871
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03338448
66Maternal diabetes (HP:0009800)2.01183531
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00942847
68Hypomagnesemia (HP:0002917)1.95534001
69Constricted visual fields (HP:0001133)1.95408803
70Attenuation of retinal blood vessels (HP:0007843)1.94694659
71Hypoplastic left heart (HP:0004383)1.94157244
72Congenital, generalized hypertrichosis (HP:0004540)1.94149104
73Exercise intolerance (HP:0003546)1.93064242
74Abnormality of the renal medulla (HP:0100957)1.92418708
75Abnormal hair whorl (HP:0010721)1.91600855
76Increased intramyocellular lipid droplets (HP:0012240)1.90652409
77Colon cancer (HP:0003003)1.90377175
78Long nose (HP:0003189)1.87169386
79Abnormality of the renal cortex (HP:0011035)1.86988300
80Abnormality of urine glucose concentration (HP:0011016)1.86754806
81Glycosuria (HP:0003076)1.86754806
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86367905
83Aplasia/Hypoplasia of the ulna (HP:0006495)1.85454993
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85402708
85Absent septum pellucidum (HP:0001331)1.85047293
86Chorioretinal atrophy (HP:0000533)1.82636049
87Confusion (HP:0001289)1.79883839
88Microvesicular hepatic steatosis (HP:0001414)1.79710699
89Optic nerve hypoplasia (HP:0000609)1.76921534
90Abnormality of magnesium homeostasis (HP:0004921)1.76751617
91Anencephaly (HP:0002323)1.75920284
92Adactyly (HP:0009776)1.75084860
93Elevated erythrocyte sedimentation rate (HP:0003565)1.73042796
94Type II lissencephaly (HP:0007260)1.72620742
95Sclerocornea (HP:0000647)1.71809263
96Aplasia/hypoplasia of the uterus (HP:0008684)1.71031714
97Abnormality of the vertebral endplates (HP:0005106)1.68951894
98Forearm undergrowth (HP:0009821)1.67856862
99Abnormality of renal resorption (HP:0011038)1.65961934
100Abnormality of serum amino acid levels (HP:0003112)1.63886062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.33239806
2NME12.72480815
3WNK42.61883216
4TXK2.56572933
5PINK12.56129873
6NUAK12.51958492
7SMG12.46778818
8STK392.31502301
9ADRBK22.21760421
10VRK22.13684214
11FRK2.09088838
12STK162.07560833
13PDK22.07458918
14GRK12.02581593
15TSSK62.01202156
16OXSR11.91943829
17PBK1.85338393
18ZAK1.80640814
19CDC71.78725333
20TLK11.67728756
21MAP4K21.67675229
22VRK11.64198303
23WNK31.64054966
24PLK41.62687588
25BCKDK1.62089168
26MAPK151.53803035
27MAP3K91.43036399
28MST41.40807800
29PASK1.35184167
30CDK191.33182189
31EIF2AK11.27840955
32MAP2K61.22741818
33ADRBK11.22717454
34PLK31.22186402
35IRAK41.22163230
36NEK11.19233232
37BMPR1B1.17553905
38PAK31.09546108
39TAF11.08651796
40EPHA41.08044864
41PKN11.05920169
42CAMK11.05614000
43DYRK21.02278666
44MAP4K11.00012167
45KIT0.97867675
46INSRR0.96853124
47LRRK20.86689840
48TEC0.86665428
49TIE10.85981733
50DYRK1B0.84964825
51ARAF0.82585066
52CSNK1G20.80263815
53RPS6KA50.79694102
54ERBB30.77881601
55PAK20.77859826
56BUB10.75001389
57TNIK0.72864769
58MKNK10.72359682
59NTRK20.70826942
60CSNK2A20.70724797
61SRPK10.66276751
62CSNK2A10.65453533
63AKT20.62213709
64PIK3CA0.61950292
65AURKB0.61312643
66ACVR1B0.60741016
67CSNK1G30.57792651
68STK110.57698185
69PRKCE0.57198091
70PRKCG0.56088374
71WNK10.54643965
72EIF2AK30.54562588
73PRKACA0.53987559
74MOS0.53135404
75CSNK1G10.51446036
76PLK20.51225613
77ITK0.50417751
78IRAK10.48524623
79CAMK2A0.48280210
80TGFBR10.46046640
81OBSCN0.45407135
82PRKCA0.45335153
83ATR0.44895380
84MAPKAPK50.44290011
85PHKG20.44023780
86PHKG10.44023780
87ABL20.42498837
88PRKCQ0.41344937
89PRKCZ0.40993873
90AURKA0.40935223
91PRKCD0.40645688
92CSNK1E0.40611066
93IKBKB0.38722901
94LYN0.38102207
95PRKG10.36355302
96CSNK1A1L0.35676889
97SIK20.34015346
98DAPK30.33994161
99CHEK20.33184903
100RPS6KA10.32721017

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.23002114
2Oxidative phosphorylation_Homo sapiens_hsa001904.17965493
3Sulfur metabolism_Homo sapiens_hsa009203.68065733
4Parkinsons disease_Homo sapiens_hsa050123.60148238
5Protein export_Homo sapiens_hsa030602.70209315
6Sulfur relay system_Homo sapiens_hsa041222.50089190
7RNA polymerase_Homo sapiens_hsa030202.47048097
8Proteasome_Homo sapiens_hsa030502.44424391
9Huntingtons disease_Homo sapiens_hsa050162.34741016
10Alzheimers disease_Homo sapiens_hsa050102.31481991
11Homologous recombination_Homo sapiens_hsa034402.23469328
12Asthma_Homo sapiens_hsa053102.22182259
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07429982
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91816142
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85052912
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83258175
17One carbon pool by folate_Homo sapiens_hsa006701.79871842
18Cardiac muscle contraction_Homo sapiens_hsa042601.77267471
19Mismatch repair_Homo sapiens_hsa034301.57435411
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.51062103
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48272530
22Folate biosynthesis_Homo sapiens_hsa007901.43809383
23Pyrimidine metabolism_Homo sapiens_hsa002401.35731628
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.34726915
25RNA degradation_Homo sapiens_hsa030181.28950442
26DNA replication_Homo sapiens_hsa030301.27989787
27Phototransduction_Homo sapiens_hsa047441.27395912
28Linoleic acid metabolism_Homo sapiens_hsa005911.21488277
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.18891534
30Basal transcription factors_Homo sapiens_hsa030221.16761522
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14315771
32Collecting duct acid secretion_Homo sapiens_hsa049661.13615263
33Allograft rejection_Homo sapiens_hsa053301.12562345
34Purine metabolism_Homo sapiens_hsa002301.10528188
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09621126
36Propanoate metabolism_Homo sapiens_hsa006401.09396260
37Autoimmune thyroid disease_Homo sapiens_hsa053201.09311445
38Nucleotide excision repair_Homo sapiens_hsa034200.98933187
39Tryptophan metabolism_Homo sapiens_hsa003800.98634437
40Peroxisome_Homo sapiens_hsa041460.98311793
41Base excision repair_Homo sapiens_hsa034100.97370727
42Fanconi anemia pathway_Homo sapiens_hsa034600.96088199
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95521399
44Butanoate metabolism_Homo sapiens_hsa006500.93751244
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89243459
46Fatty acid biosynthesis_Homo sapiens_hsa000610.88442769
47Retinol metabolism_Homo sapiens_hsa008300.85671460
48RNA transport_Homo sapiens_hsa030130.84302041
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83113649
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80296396
51Chemical carcinogenesis_Homo sapiens_hsa052040.76200184
52Basal cell carcinoma_Homo sapiens_hsa052170.76132283
53Hedgehog signaling pathway_Homo sapiens_hsa043400.75904657
54Metabolic pathways_Homo sapiens_hsa011000.73254100
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70858377
56Spliceosome_Homo sapiens_hsa030400.69930981
57Non-homologous end-joining_Homo sapiens_hsa034500.69909690
58Type I diabetes mellitus_Homo sapiens_hsa049400.68324816
59Glutathione metabolism_Homo sapiens_hsa004800.65171448
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64416587
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62865469
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61373230
63Arachidonic acid metabolism_Homo sapiens_hsa005900.60938829
64Nitrogen metabolism_Homo sapiens_hsa009100.60616174
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58949919
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58812405
67Fat digestion and absorption_Homo sapiens_hsa049750.57613593
68Selenocompound metabolism_Homo sapiens_hsa004500.56311795
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55377083
70Pyruvate metabolism_Homo sapiens_hsa006200.54011674
71Pancreatic secretion_Homo sapiens_hsa049720.52686662
72Rheumatoid arthritis_Homo sapiens_hsa053230.50635148
73Caffeine metabolism_Homo sapiens_hsa002320.46363683
74Vitamin digestion and absorption_Homo sapiens_hsa049770.45979051
75Salivary secretion_Homo sapiens_hsa049700.44764551
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44715436
77Vitamin B6 metabolism_Homo sapiens_hsa007500.43741111
78Graft-versus-host disease_Homo sapiens_hsa053320.43273074
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41217993
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40454146
81Morphine addiction_Homo sapiens_hsa050320.38594799
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38468211
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.37238806
84Insulin secretion_Homo sapiens_hsa049110.36834459
85p53 signaling pathway_Homo sapiens_hsa041150.36611305
86Glycerolipid metabolism_Homo sapiens_hsa005610.36515927
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35846989
88Nicotine addiction_Homo sapiens_hsa050330.35378789
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35189861
90Fatty acid degradation_Homo sapiens_hsa000710.34892991
91Olfactory transduction_Homo sapiens_hsa047400.32581839
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32024287
93Taste transduction_Homo sapiens_hsa047420.31731043
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30579791
95Tyrosine metabolism_Homo sapiens_hsa003500.30070589
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28087228
97Ether lipid metabolism_Homo sapiens_hsa005650.27643779
98beta-Alanine metabolism_Homo sapiens_hsa004100.27399487
99Protein digestion and absorption_Homo sapiens_hsa049740.22624211
100Serotonergic synapse_Homo sapiens_hsa047260.22570233

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