ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.97422486
2	ribosomal small subunit assembly (GO:0000028)	6.92883287
3	translational termination (GO:0006415)	6.67401712
4	DNA deamination (GO:0045006)	5.87756797
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.75669384
6	translational elongation (GO:0006414)	5.68822315
7	cotranslational protein targeting to membrane (GO:0006613)	5.66246760
8	protein targeting to ER (GO:0045047)	5.62049918
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.34288583
10	protein localization to endoplasmic reticulum (GO:0070972)	5.26750415
11	sequestering of actin monomers (GO:0042989)	5.15910013
12	cytidine metabolic process (GO:0046087)	5.09715064
13	cytidine catabolic process (GO:0006216)	5.09715064
14	cytidine deamination (GO:0009972)	5.09715064
15	cellular protein complex disassembly (GO:0043624)	5.05439834
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.95547892
17	viral life cycle (GO:0019058)	4.95261081
18	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.77545200
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.74513692
20	ATP synthesis coupled proton transport (GO:0015986)	4.71928728
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.71928728
22	translational initiation (GO:0006413)	4.38720791
23	ribosomal small subunit biogenesis (GO:0042274)	4.34955412
24	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.31815847
25	protein complex disassembly (GO:0043241)	4.18462514
26	ribosomal large subunit biogenesis (GO:0042273)	4.05113038
27	behavioral response to nicotine (GO:0035095)	4.01809466
28	macromolecular complex disassembly (GO:0032984)	3.93964549
29	protein targeting to membrane (GO:0006612)	3.60540449
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.57504931
31	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.57485988
32	negative regulation by host of viral transcription (GO:0043922)	3.55123534
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.51824065
34	protein neddylation (GO:0045116)	3.50843196
35	maturation of SSU-rRNA (GO:0030490)	3.37036053
36	translation (GO:0006412)	3.36420734
37	respiratory electron transport chain (GO:0022904)	3.33985453
38	electron transport chain (GO:0022900)	3.30266888
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.26011099
40	platelet dense granule organization (GO:0060155)	3.19145738
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.09266261
42	protein complex biogenesis (GO:0070271)	3.07312583
43	mRNA catabolic process (GO:0006402)	3.07013507
44	negative T cell selection (GO:0043383)	3.05125522
45	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.98767035
46	forebrain morphogenesis (GO:0048853)	2.90975328
47	negative regulation of T cell apoptotic process (GO:0070233)	2.90952374
48	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.89540220
49	indolalkylamine metabolic process (GO:0006586)	2.87969332
50	positive thymic T cell selection (GO:0045059)	2.87422190
51	positive regulation of T cell apoptotic process (GO:0070234)	2.84061349
52	regulation of regulatory T cell differentiation (GO:0045589)	2.82229417
53	positive regulation of calcium-mediated signaling (GO:0050850)	2.80463328
54	positive T cell selection (GO:0043368)	2.80193403
55	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.80073284
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.79280001
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.79280001
58	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.75363340
59	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74519953
60	regulation of activation of Janus kinase activity (GO:0010533)	2.74222622
61	ATP biosynthetic process (GO:0006754)	2.71893919
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.71762975
63	ubiquinone biosynthetic process (GO:0006744)	2.71455937
64	GTP biosynthetic process (GO:0006183)	2.71348318
65	RNA catabolic process (GO:0006401)	2.70213467
66	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.70042950
67	proteasome assembly (GO:0043248)	2.66078297
68	epithelial cilium movement (GO:0003351)	2.65959688
69	positive regulation of prostaglandin secretion (GO:0032308)	2.65104666
70	ribonucleoprotein complex biogenesis (GO:0022613)	2.63805872
71	hydrogen ion transmembrane transport (GO:1902600)	2.59682369
72	sulfation (GO:0051923)	2.59106643
73	positive regulation of tolerance induction (GO:0002645)	2.57865771
74	indole-containing compound catabolic process (GO:0042436)	2.57369026
75	indolalkylamine catabolic process (GO:0046218)	2.57369026
76	tryptophan catabolic process (GO:0006569)	2.57369026
77	negative thymic T cell selection (GO:0045060)	2.57251097
78	GPI anchor metabolic process (GO:0006505)	2.54305304
79	regulation of chronic inflammatory response (GO:0002676)	2.54285170
80	cellular component biogenesis (GO:0044085)	2.54258784
81	dopaminergic neuron differentiation (GO:0071542)	2.54161254
82	negative regulation of T cell differentiation in thymus (GO:0033085)	2.53820415
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53662191
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53662191
85	NADH dehydrogenase complex assembly (GO:0010257)	2.53662191
86	T cell migration (GO:0072678)	2.52112998
87	ubiquinone metabolic process (GO:0006743)	2.51880951
88	regulation of T cell receptor signaling pathway (GO:0050856)	2.51776283
89	response to pheromone (GO:0019236)	2.49681102
90	proton transport (GO:0015992)	2.49539002
91	response to interferon-beta (GO:0035456)	2.48544813
92	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.48239003
93	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.46480456
94	hydrogen transport (GO:0006818)	2.44993723
95	tolerance induction (GO:0002507)	2.41777538
96	positive regulation of gastrulation (GO:2000543)	2.41697686
97	positive regulation of interleukin-8 secretion (GO:2000484)	2.40645944
98	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.39058503
99	inner mitochondrial membrane organization (GO:0007007)	2.37024069
100	establishment of protein localization to membrane (GO:0090150)	2.36810360

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.50178921
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.36599081
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.11265390
4	VDR_22108803_ChIP-Seq_LS180_Human	2.89209823
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.89171465
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.88494327
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.72738828
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51558271
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.51140906
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35533644
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.29556950
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24078276
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.13727541
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.06340399
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04716695
16	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.01954526
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.00351239
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84457122
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.83819364
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.82819658
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82175452
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.72581780
23	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.67450484
24	EWS_26573619_Chip-Seq_HEK293_Human	1.63943220
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58651961
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.58273405
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.56543656
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49067105
29	FUS_26573619_Chip-Seq_HEK293_Human	1.49062601
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48247614
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46887123
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46887123
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.46058715
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45325849
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.41079662
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40974257
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.40869254
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.40130848
39	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40098218
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.39092482
41	AR_20517297_ChIP-Seq_VCAP_Human	1.38947633
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.36146695
43	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.35922123
44	NCOR_22424771_ChIP-Seq_293T_Human	1.35050480
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.34431292
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34151206
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31832424
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30366978
49	P300_19829295_ChIP-Seq_ESCs_Human	1.30205742
50	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29055867
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27069591
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.26982893
53	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26485102
54	GBX2_23144817_ChIP-Seq_PC3_Human	1.25715574
55	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.25696684
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.22089219
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22045826
58	RUNX_20019798_ChIP-Seq_JUKART_Human	1.21932930
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21722243
60	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19517695
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17740211
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17740211
63	MYB_26560356_Chip-Seq_TH2_Human	1.16393581
64	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15780210
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.15705244
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14564780
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14488828
68	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14212852
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13175697
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12617459
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.12617459
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12506415
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10705578
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.09590278
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09470344
76	GATA3_26560356_Chip-Seq_TH2_Human	1.09373300
77	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.09001625
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08003504
79	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07768454
80	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06942136
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04978332
82	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03860621
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03456902
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.00437457
85	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99522030
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99074036
87	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98602901
88	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98559597
89	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.97538414
90	GATA3_27048872_Chip-Seq_THYMUS_Human	0.97088318
91	FOXP3_21729870_ChIP-Seq_TREG_Human	0.96177142
92	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95266773
93	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.94715962
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94265766
95	ERA_21632823_ChIP-Seq_H3396_Human	0.93483650
96	IRF1_19129219_ChIP-ChIP_H3396_Human	0.92951770
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92892038
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.92005351
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91691142
100	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.91321517

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.82316116
2	MP0005671_abnormal_response_to	3.48385980
3	MP0002837_dystrophic_cardiac_calcinosis	2.63353417
4	MP0002653_abnormal_ependyma_morphology	2.56481270
5	MP0004147_increased_porphyrin_level	2.42928610
6	MP0006292_abnormal_olfactory_placode	2.25474956
7	MP0003283_abnormal_digestive_organ	2.00060094
8	MP0002638_abnormal_pupillary_reflex	1.99311190
9	MP0009785_altered_susceptibility_to	1.91558453
10	MP0004145_abnormal_muscle_electrophysio	1.89000004
11	MP0005084_abnormal_gallbladder_morpholo	1.87342539
12	MP0000372_irregular_coat_pigmentation	1.86564451
13	MP0004885_abnormal_endolymph	1.83896928
14	MP0005645_abnormal_hypothalamus_physiol	1.70608778
15	MP0005646_abnormal_pituitary_gland	1.63504951
16	MP0008995_early_reproductive_senescence	1.60907068
17	MP0009333_abnormal_splenocyte_physiolog	1.58413813
18	MP0002163_abnormal_gland_morphology	1.58299937
19	MP0008872_abnormal_physiological_respon	1.56875175
20	MP0006072_abnormal_retinal_apoptosis	1.55507141
21	MP0008877_abnormal_DNA_methylation	1.54150850
22	MP0003195_calcinosis	1.53861851
23	MP0001835_abnormal_antigen_presentation	1.52899593
24	MP0002277_abnormal_respiratory_mucosa	1.50913497
25	MP0003011_delayed_dark_adaptation	1.49769860
26	MP0001905_abnormal_dopamine_level	1.49581555
27	MP0005551_abnormal_eye_electrophysiolog	1.47819543
28	MP0003763_abnormal_thymus_physiology	1.45963483
29	MP0001968_abnormal_touch/_nociception	1.44291267
30	MP0002102_abnormal_ear_morphology	1.44007153
31	MP0001873_stomach_inflammation	1.42814107
32	MP0000566_synostosis	1.38655632
33	MP0002736_abnormal_nociception_after	1.36562325
34	MP0001800_abnormal_humoral_immune	1.35576659
35	MP0005083_abnormal_biliary_tract	1.35480775
36	MP0002148_abnormal_hypersensitivity_rea	1.35156738
37	MP0002876_abnormal_thyroid_physiology	1.34777743
38	MP0002160_abnormal_reproductive_system	1.32756515
39	MP0001529_abnormal_vocalization	1.30920930
40	MP0002234_abnormal_pharynx_morphology	1.29567157
41	MP0005379_endocrine/exocrine_gland_phen	1.29431332
42	MP0005389_reproductive_system_phenotype	1.29226815
43	MP0001188_hyperpigmentation	1.27387330
44	MP0000685_abnormal_immune_system	1.27046056
45	MP0003646_muscle_fatigue	1.26343208
46	MP0004742_abnormal_vestibular_system	1.24951269
47	MP0003880_abnormal_central_pattern	1.21016162
48	MP0005000_abnormal_immune_tolerance	1.20415546
49	MP0003252_abnormal_bile_duct	1.19889817
50	MP0002723_abnormal_immune_serum	1.17634572
51	MP0003866_abnormal_defecation	1.16477144
52	MP0001764_abnormal_homeostasis	1.13345756
53	MP0010386_abnormal_urinary_bladder	1.12192908
54	MP0003136_yellow_coat_color	1.12038365
55	MP0002420_abnormal_adaptive_immunity	1.11707804
56	MP0005253_abnormal_eye_physiology	1.09031162
57	MP0002928_abnormal_bile_duct	1.08222306
58	MP0005025_abnormal_response_to	1.06982676
59	MP0005377_hearing/vestibular/ear_phenot	1.06826450
60	MP0003878_abnormal_ear_physiology	1.06826450
61	MP0001919_abnormal_reproductive_system	1.06760767
62	MP0001819_abnormal_immune_cell	1.06693295
63	MP0006054_spinal_hemorrhage	1.06218577
64	MP0002693_abnormal_pancreas_physiology	1.03639412
65	MP0005387_immune_system_phenotype	1.02394657
66	MP0001790_abnormal_immune_system	1.02394657
67	MP0008875_abnormal_xenobiotic_pharmacok	1.00590729
68	MP0006276_abnormal_autonomic_nervous	0.99479195
69	MP0002822_catalepsy	0.99186354
70	MP0010155_abnormal_intestine_physiology	0.98933458
71	MP0001986_abnormal_taste_sensitivity	0.98616185
72	MP0000631_abnormal_neuroendocrine_gland	0.96647132
73	MP0002138_abnormal_hepatobiliary_system	0.95015329
74	MP0002095_abnormal_skin_pigmentation	0.93873681
75	MP0006082_CNS_inflammation	0.92856110
76	MP0003315_abnormal_perineum_morphology	0.92731039
77	MP0009745_abnormal_behavioral_response	0.91732843
78	MP0004133_heterotaxia	0.91347324
79	MP0000716_abnormal_immune_system	0.90950524
80	MP0004142_abnormal_muscle_tone	0.89740501
81	MP0002272_abnormal_nervous_system	0.89351016
82	MP0000026_abnormal_inner_ear	0.85607115
83	MP0002398_abnormal_bone_marrow	0.84999301
84	MP0001485_abnormal_pinna_reflex	0.84984392
85	MP0005410_abnormal_fertilization	0.82843625
86	MP0002166_altered_tumor_susceptibility	0.82612593
87	MP0002452_abnormal_antigen_presenting	0.81113299
88	MP0005085_abnormal_gallbladder_physiolo	0.80431061
89	MP0003806_abnormal_nucleotide_metabolis	0.79359737
90	MP0003786_premature_aging	0.77850680
91	MP0002405_respiratory_system_inflammati	0.76632978
92	MP0002933_joint_inflammation	0.75988933
93	MP0002938_white_spotting	0.75507396
94	MP0005636_abnormal_mineral_homeostasis	0.75059369
95	MP0001501_abnormal_sleep_pattern	0.74123994
96	MP0000689_abnormal_spleen_morphology	0.73118015
97	MP0002006_tumorigenesis	0.72053925
98	MP0005075_abnormal_melanosome_morpholog	0.71876323
99	MP0000703_abnormal_thymus_morphology	0.71504670
100	MP0001845_abnormal_inflammatory_respons	0.69996359

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.98171074
2	Mitochondrial inheritance (HP:0001427)	3.84987447
3	Absent/shortened dynein arms (HP:0200106)	3.74719188
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.74719188
5	Chronic hepatic failure (HP:0100626)	3.70573073
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.63859196
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.55326657
8	Abnormal number of erythroid precursors (HP:0012131)	3.52901212
9	Progressive macrocephaly (HP:0004481)	3.45016954
10	Congenital stationary night blindness (HP:0007642)	3.44796892
11	Severe combined immunodeficiency (HP:0004430)	3.40218344
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.31830713
13	Abnormal ciliary motility (HP:0012262)	3.31790867
14	Pancreatic cysts (HP:0001737)	3.30086825
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.28346351
16	Acute encephalopathy (HP:0006846)	3.24123494
17	3-Methylglutaconic aciduria (HP:0003535)	3.21598561
18	Abnormal respiratory motile cilium morphology (HP:0005938)	3.19647280
19	Abnormal respiratory epithelium morphology (HP:0012253)	3.19647280
20	Macrocytic anemia (HP:0001972)	3.18026910
21	Increased hepatocellular lipid droplets (HP:0006565)	3.17759760
22	Thyroiditis (HP:0100646)	3.16065195
23	True hermaphroditism (HP:0010459)	3.12696423
24	Elevated erythrocyte sedimentation rate (HP:0003565)	3.12482374
25	Increased CSF lactate (HP:0002490)	3.11246557
26	Reticulocytopenia (HP:0001896)	3.08985120
27	Abnormal respiratory motile cilium physiology (HP:0012261)	3.05727752
28	IgG deficiency (HP:0004315)	3.04555999
29	Hepatocellular necrosis (HP:0001404)	3.00168075
30	Optic disc pallor (HP:0000543)	2.94064372
31	Hypoproteinemia (HP:0003075)	2.93849047
32	Renal Fanconi syndrome (HP:0001994)	2.91668365
33	Decreased central vision (HP:0007663)	2.88141232
34	Pancreatic fibrosis (HP:0100732)	2.87510461
35	Abnormality of T cell number (HP:0011839)	2.82799260
36	Aplastic anemia (HP:0001915)	2.80079678
37	Abnormality of midbrain morphology (HP:0002418)	2.79628536
38	Molar tooth sign on MRI (HP:0002419)	2.79628536
39	Lipid accumulation in hepatocytes (HP:0006561)	2.78014480
40	Attenuation of retinal blood vessels (HP:0007843)	2.76619426
41	Abnormality of the renal cortex (HP:0011035)	2.75721199
42	Hepatic necrosis (HP:0002605)	2.74607565
43	T lymphocytopenia (HP:0005403)	2.72509531
44	Autoimmune hemolytic anemia (HP:0001890)	2.66045443
45	Abnormality of B cell number (HP:0010975)	2.65606185
46	Cerebral edema (HP:0002181)	2.63907457
47	Methylmalonic acidemia (HP:0002912)	2.60844359
48	Increased IgM level (HP:0003496)	2.60809234
49	Pallor (HP:0000980)	2.56259333
50	Renal cortical cysts (HP:0000803)	2.54049014
51	Combined immunodeficiency (HP:0005387)	2.53303077
52	Increased intramyocellular lipid droplets (HP:0012240)	2.51928274
53	Chronic sinusitis (HP:0011109)	2.43362197
54	Hyperglycinemia (HP:0002154)	2.38901356
55	Abnormality of eosinophils (HP:0001879)	2.29395135
56	Exertional dyspnea (HP:0002875)	2.28465877
57	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.23985366
58	Abnormality of T cells (HP:0002843)	2.19624885
59	Abnormality of the prostate (HP:0008775)	2.18086621
60	Abolished electroretinogram (ERG) (HP:0000550)	2.17974120
61	B lymphocytopenia (HP:0010976)	2.16494737
62	Cystic liver disease (HP:0006706)	2.15449970
63	Rhinitis (HP:0012384)	2.13696847
64	Congenital, generalized hypertrichosis (HP:0004540)	2.12295404
65	Polydipsia (HP:0001959)	2.07553283
66	Abnormal drinking behavior (HP:0030082)	2.07553283
67	Constricted visual fields (HP:0001133)	2.06983814
68	Nephronophthisis (HP:0000090)	2.04992759
69	Glycosuria (HP:0003076)	2.04461275
70	Abnormality of urine glucose concentration (HP:0011016)	2.04461275
71	Stomatitis (HP:0010280)	2.00327770
72	Panhypogammaglobulinemia (HP:0003139)	1.98525988
73	Increased muscle lipid content (HP:0009058)	1.96032083
74	Abnormality of renal resorption (HP:0011038)	1.95484977
75	Methylmalonic aciduria (HP:0012120)	1.93843000
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92438304
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.90765791
78	Stenosis of the external auditory canal (HP:0000402)	1.90022566
79	Lethargy (HP:0001254)	1.89013571
80	Autoimmune thrombocytopenia (HP:0001973)	1.88434575
81	Lactic acidosis (HP:0003128)	1.87783892
82	Abnormality of macular pigmentation (HP:0008002)	1.87630215
83	Ketosis (HP:0001946)	1.87053743
84	Increased serum lactate (HP:0002151)	1.85514883
85	Abnormality of the renal medulla (HP:0100957)	1.85318548
86	Mesangial abnormality (HP:0001966)	1.85275188
87	Polyuria (HP:0000103)	1.84580552
88	Male pseudohermaphroditism (HP:0000037)	1.83189250
89	Pendular nystagmus (HP:0012043)	1.81492829
90	Asplenia (HP:0001746)	1.80942614
91	Chronic otitis media (HP:0000389)	1.80774589
92	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.80767336
93	Absent thumb (HP:0009777)	1.80158147
94	Sclerocornea (HP:0000647)	1.77318901
95	Eosinophilia (HP:0001880)	1.76225243
96	Bronchiectasis (HP:0002110)	1.75806629
97	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75385271
98	Pancytopenia (HP:0001876)	1.75086003
99	Respiratory difficulties (HP:0002880)	1.74167863
100	Increased corneal curvature (HP:0100692)	1.73069495

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PASK	5.05631483
2	TXK	4.55296864
3	VRK2	3.64755052
4	KDR	3.16144853
5	VRK1	2.54335166
6	MAP4K1	2.46220265
7	ZAK	2.42935177
8	ADRBK2	2.26932951
9	MAPK15	2.22167080
10	FRK	2.01704199
11	MAP4K2	1.99934842
12	GRK1	1.86671973
13	NUAK1	1.81540172
14	CAMKK1	1.78268622
15	BCKDK	1.76602685
16	ITK	1.66622170
17	TEC	1.65693402
18	PINK1	1.62107004
19	TESK2	1.60299358
20	CDK19	1.51848112
21	KIT	1.48151925
22	FES	1.42630516
23	TAOK3	1.38363079
24	TLK1	1.37820203
25	SYK	1.32104567
26	INSRR	1.30707142
27	WNK4	1.28964870
28	BMPR1B	1.26568288
29	CAMKK2	1.24904753
30	NEK2	1.22896163
31	PRKCQ	1.21666496
32	MUSK	1.19534954
33	TAF1	1.12653331
34	BTK	1.11286653
35	TIE1	1.08445872
36	MAP3K12	1.05840963
37	TGFBR1	1.02847320
38	LCK	0.99573243
39	IKBKB	0.96438199
40	CCNB1	0.92927831
41	ADRBK1	0.92812816
42	NME1	0.91809981
43	MAP3K11	0.91688281
44	DYRK2	0.91465328
45	WNK3	0.88311472
46	ACVR1B	0.83585431
47	LIMK1	0.83379886
48	LRRK2	0.77756063
49	OBSCN	0.77724346
50	OXSR1	0.74852548
51	MAPK13	0.73321149
52	LYN	0.71589760
53	GRK6	0.69415073
54	PIK3CA	0.66312595
55	STK16	0.65078678
56	SIK2	0.64527618
57	PNCK	0.64518282
58	MATK	0.63240484
59	ZAP70	0.62779751
60	GRK7	0.62697797
61	DAPK2	0.62690155
62	JAK3	0.62504940
63	MAPKAPK3	0.59718309
64	EPHB2	0.56599607
65	MAP2K7	0.56461994
66	RPS6KA5	0.54867252
67	BRSK2	0.52063101
68	CSF1R	0.51079600
69	PRKACA	0.49400605
70	DAPK3	0.48465562
71	TYRO3	0.47535031
72	IKBKE	0.46395013
73	PBK	0.45282358
74	PIM1	0.45268630
75	MARK3	0.44986018
76	PRKCA	0.44919223
77	STK11	0.43673528
78	TNK2	0.42824762
79	PRKCD	0.42555653
80	CSK	0.42322255
81	MAP2K6	0.42248404
82	WEE1	0.41537747
83	PRKCE	0.41402562
84	FGFR2	0.40851958
85	PIK3CG	0.40531521
86	IGF1R	0.40362028
87	MAPKAPK5	0.40245929
88	PRKCH	0.39767639
89	CSNK1G3	0.38863779
90	BUB1	0.38329318
91	RPS6KB2	0.38034521
92	MAP3K5	0.36457486
93	FLT3	0.35742387
94	MAP3K4	0.34890738
95	CAMK1	0.34274360
96	TRPM7	0.33170455
97	DAPK1	0.33118435
98	AURKA	0.32674316
99	CSNK1G1	0.31679898
100	CSNK2A2	0.31673348

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.58784372
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.77236800
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.76760034
4	Parkinsons disease_Homo sapiens_hsa05012	3.02939925
5	Proteasome_Homo sapiens_hsa03050	2.65186658
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.11868520
7	Alzheimers disease_Homo sapiens_hsa05010	2.01814039
8	Allograft rejection_Homo sapiens_hsa05330	2.00107621
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.98256874
10	Graft-versus-host disease_Homo sapiens_hsa05332	1.96429649
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.93107489
12	Huntingtons disease_Homo sapiens_hsa05016	1.92063643
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.88358096
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.84899068
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.80841691
16	Phototransduction_Homo sapiens_hsa04744	1.77133889
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.73554948
18	Caffeine metabolism_Homo sapiens_hsa00232	1.69662202
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.65023564
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.63611927
21	RNA polymerase_Homo sapiens_hsa03020	1.62306864
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.60555699
23	Protein export_Homo sapiens_hsa03060	1.59700121
24	Asthma_Homo sapiens_hsa05310	1.57613931
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56896871
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.48139360
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42491234
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.33018977
29	Butanoate metabolism_Homo sapiens_hsa00650	1.29031324
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27273632
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.23354269
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21747089
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20720003
34	Olfactory transduction_Homo sapiens_hsa04740	1.07529876
35	RNA degradation_Homo sapiens_hsa03018	1.04597989
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04140678
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.02724931
38	Retinol metabolism_Homo sapiens_hsa00830	1.01984243
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01413397
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00627491
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.00525086
42	Homologous recombination_Homo sapiens_hsa03440	1.00475245
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99272301
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99253460
45	Peroxisome_Homo sapiens_hsa04146	0.96775622
46	Basal transcription factors_Homo sapiens_hsa03022	0.95789127
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93228545
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91649008
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.90790940
50	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.87673489
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85493987
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.77670502
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.76202721
54	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.75897606
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75779527
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75285561
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74951680
58	Propanoate metabolism_Homo sapiens_hsa00640	0.74318873
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73289541
60	Purine metabolism_Homo sapiens_hsa00230	0.69431097
61	Nicotine addiction_Homo sapiens_hsa05033	0.69285100
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.67099236
63	Taste transduction_Homo sapiens_hsa04742	0.67014126
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.66175079
65	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60938805
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59701985
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55946900
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.55088007
69	Salivary secretion_Homo sapiens_hsa04970	0.54424419
70	Sulfur metabolism_Homo sapiens_hsa00920	0.53252423
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51806389
72	Metabolic pathways_Homo sapiens_hsa01100	0.51327230
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49693437
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.49577962
75	Regulation of autophagy_Homo sapiens_hsa04140	0.49264038
76	Malaria_Homo sapiens_hsa05144	0.47165838
77	Mineral absorption_Homo sapiens_hsa04978	0.44179311
78	One carbon pool by folate_Homo sapiens_hsa00670	0.42946062
79	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42341362
80	African trypanosomiasis_Homo sapiens_hsa05143	0.42309137
81	ABC transporters_Homo sapiens_hsa02010	0.40597317
82	Measles_Homo sapiens_hsa05162	0.39511796
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.37866236
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36146923
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35605268
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32673412
87	Base excision repair_Homo sapiens_hsa03410	0.31625544
88	Glutathione metabolism_Homo sapiens_hsa00480	0.30147589
89	Serotonergic synapse_Homo sapiens_hsa04726	0.30122685
90	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.29857292
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29614681
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.29588351
93	Morphine addiction_Homo sapiens_hsa05032	0.27605646
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.26345789
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26228659
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.25154607
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.25128236
98	Cocaine addiction_Homo sapiens_hsa05030	0.23172199
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.22520816
100	Insulin secretion_Homo sapiens_hsa04911	0.22318083

RPL12P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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