RPL13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.37339754
2* viral transcription (GO:0019083)7.57263345
3* translational termination (GO:0006415)7.26559221
4* translational elongation (GO:0006414)6.34287964
5ribosomal small subunit biogenesis (GO:0042274)6.31937895
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.20901807
7* protein targeting to ER (GO:0045047)6.04036147
8* cotranslational protein targeting to membrane (GO:0006613)6.03134831
9maturation of SSU-rRNA (GO:0030490)5.80302284
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.74454255
11* protein localization to endoplasmic reticulum (GO:0070972)5.72696450
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.72651925
13* viral life cycle (GO:0019058)5.63343331
14* cellular protein complex disassembly (GO:0043624)5.58710469
15* translational initiation (GO:0006413)5.52250657
16DNA deamination (GO:0045006)5.50490939
17ribosomal large subunit biogenesis (GO:0042273)5.29067589
18* protein complex disassembly (GO:0043241)5.02544649
19* macromolecular complex disassembly (GO:0032984)4.68240548
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.45525726
21* nuclear-transcribed mRNA catabolic process (GO:0000956)4.32046210
22ribonucleoprotein complex biogenesis (GO:0022613)4.28798695
23DNA strand elongation involved in DNA replication (GO:0006271)4.16698543
24telomere maintenance via semi-conservative replication (GO:0032201)4.14160746
25* mRNA catabolic process (GO:0006402)4.10406852
26substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.03871811
27substrate-independent telencephalic tangential migration (GO:0021826)4.03871811
28chaperone-mediated protein transport (GO:0072321)4.01063893
29DNA strand elongation (GO:0022616)3.99107548
30* protein targeting to membrane (GO:0006612)3.98985732
31* translation (GO:0006412)3.96963094
32pyrimidine nucleotide catabolic process (GO:0006244)3.95175925
33* RNA catabolic process (GO:0006401)3.89634707
34* protein localization to membrane (GO:0072657)3.80917070
35formation of translation preinitiation complex (GO:0001731)3.78509740
36cell proliferation in forebrain (GO:0021846)3.75790980
37tongue development (GO:0043586)3.73600432
38telomere maintenance via recombination (GO:0000722)3.60737837
39pattern specification involved in kidney development (GO:0061004)3.52778640
40DNA replication initiation (GO:0006270)3.52136739
41rRNA processing (GO:0006364)3.50875456
42DNA unwinding involved in DNA replication (GO:0006268)3.48464121
43rRNA metabolic process (GO:0016072)3.37773323
44mitotic recombination (GO:0006312)3.32183163
45ATP synthesis coupled proton transport (GO:0015986)3.28359457
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28359457
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.23858465
48NADH dehydrogenase complex assembly (GO:0010257)3.23858465
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23858465
50telomere maintenance via telomere lengthening (GO:0010833)3.23276396
51DNA replication-dependent nucleosome organization (GO:0034723)3.20689767
52DNA replication-dependent nucleosome assembly (GO:0006335)3.20689767
53cellular component biogenesis (GO:0044085)3.19601245
54ribosome biogenesis (GO:0042254)3.19070354
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.15844831
56negative regulation of RNA splicing (GO:0033119)3.15151349
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06099623
58UTP biosynthetic process (GO:0006228)3.02847548
59nucleobase biosynthetic process (GO:0046112)3.01733384
60behavioral response to nicotine (GO:0035095)3.00961004
61segment specification (GO:0007379)3.00842908
62GTP biosynthetic process (GO:0006183)2.99718828
63spliceosomal snRNP assembly (GO:0000387)2.95618983
64positive regulation of respiratory burst (GO:0060267)2.95105670
65heterochromatin organization (GO:0070828)2.93598028
66protein localization to kinetochore (GO:0034501)2.88943848
67positive regulation of T cell apoptotic process (GO:0070234)2.85152469
68hypothalamus development (GO:0021854)2.85104442
69pseudouridine synthesis (GO:0001522)2.84368271
70maturation of 5.8S rRNA (GO:0000460)2.83654621
71negative regulation of granulocyte differentiation (GO:0030853)2.82580216
72* protein localization to organelle (GO:0033365)2.82323164
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80243223
74IMP biosynthetic process (GO:0006188)2.78973056
75chromatin remodeling at centromere (GO:0031055)2.78115643
76CENP-A containing nucleosome assembly (GO:0034080)2.77745953
77protein complex biogenesis (GO:0070271)2.77238037
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76495990
79ncRNA 3-end processing (GO:0043628)2.74815531
80transcription-coupled nucleotide-excision repair (GO:0006283)2.74519632
81DNA replication checkpoint (GO:0000076)2.72606921
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72519237
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72519237
84UTP metabolic process (GO:0046051)2.70904656
85deoxyribonucleotide catabolic process (GO:0009264)2.69438846
86termination of RNA polymerase II transcription (GO:0006369)2.68318806
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67838010
88folic acid-containing compound biosynthetic process (GO:0009396)2.67605724
89* cellular component disassembly (GO:0022411)2.66623571
90* establishment of protein localization to membrane (GO:0090150)2.66191523
91histone mRNA metabolic process (GO:0008334)2.65593721
92purine nucleobase biosynthetic process (GO:0009113)2.65162860
93* establishment of protein localization to organelle (GO:0072594)2.64626813
94mitotic nuclear envelope disassembly (GO:0007077)2.64523074
95DNA replication-independent nucleosome organization (GO:0034724)2.62199167
96DNA replication-independent nucleosome assembly (GO:0006336)2.62199167
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.61440664
98regulation of respiratory burst (GO:0060263)2.59543960
99cardiovascular system development (GO:0072358)2.59284801
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58916795
101protein localization to chromosome, centromeric region (GO:0071459)2.58083092
102somite development (GO:0061053)2.57067909
103regulation of somitogenesis (GO:0014807)2.56895412
104CTP metabolic process (GO:0046036)2.56796457
105CTP biosynthetic process (GO:0006241)2.56796457
106cell wall macromolecule metabolic process (GO:0044036)2.56739691
107cell wall macromolecule catabolic process (GO:0016998)2.56739691
108translesion synthesis (GO:0019985)2.56256122
109telomere maintenance (GO:0000723)2.55626163
110negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.55326119
111telomere organization (GO:0032200)2.54800645
112ncRNA processing (GO:0034470)2.54784168
113negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.54578348
114IMP metabolic process (GO:0046040)2.54522117
115base-excision repair, AP site formation (GO:0006285)2.53558603
116pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52919894
117mesonephros development (GO:0001823)2.52829888
118UV protection (GO:0009650)2.52226263
119* protein targeting (GO:0006605)2.51447780
120viral mRNA export from host cell nucleus (GO:0046784)2.48946438
121auditory receptor cell differentiation (GO:0042491)2.48107962
122mRNA splicing, via spliceosome (GO:0000398)2.46935143
123RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.46935143
124tRNA methylation (GO:0030488)2.46409219
125kinetochore organization (GO:0051383)2.45923193
126establishment of integrated proviral latency (GO:0075713)2.45878018
127RNA splicing, via transesterification reactions (GO:0000375)2.45575681
128negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.45348510
129regulation of hydrogen peroxide metabolic process (GO:0010310)2.45221952
130deoxyribose phosphate catabolic process (GO:0046386)2.45084111
131mitochondrial respiratory chain complex assembly (GO:0033108)2.43988168
132response to interferon-beta (GO:0035456)2.43332989
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.42422191
134membrane disassembly (GO:0030397)2.40823815
135nuclear envelope disassembly (GO:0051081)2.40823815
136pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.40133531
137ncRNA metabolic process (GO:0034660)2.40131257
138pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.40083106
139proteasome assembly (GO:0043248)2.39059036
140spliceosomal complex assembly (GO:0000245)2.38749178
141histone exchange (GO:0043486)2.38655823
142motile cilium assembly (GO:0044458)2.38160335
143regulation of mammary gland epithelial cell proliferation (GO:0033599)2.37907604
144antigen processing and presentation via MHC class Ib (GO:0002475)2.36863553
145antigen processing and presentation of endogenous antigen (GO:0019883)2.35504796
146DNA-templated transcription, termination (GO:0006353)2.35208950
147regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.35087848
148* gene expression (GO:0010467)2.35015840
149isotype switching (GO:0045190)2.35012122
150myeloid cell homeostasis (GO:0002262)2.35005024
151mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33634506
152body morphogenesis (GO:0010171)2.31613050
153establishment of protein localization to mitochondrial membrane (GO:0090151)2.31211786
154negative regulation of DNA-templated transcription, elongation (GO:0032785)2.30533718
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.29822901
156RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.27355984
157mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.26240211
158positive regulation of Notch signaling pathway (GO:0045747)2.23707967
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.19948171
160RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.19948171
161viral protein processing (GO:0019082)2.19114657
162negative regulation of organelle assembly (GO:1902116)2.18983773
163electron transport chain (GO:0022900)2.16567093
164guanosine-containing compound biosynthetic process (GO:1901070)2.16546793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.98037909
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.30768395
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85013234
4MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96846376
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92804396
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74830922
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.70603462
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66330691
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.64850699
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63464932
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.62717612
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.53977208
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52702240
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51166443
15* XRN2_22483619_ChIP-Seq_HELA_Human2.45006543
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41827718
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37123704
18* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.30106953
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29256662
20EZH2_22144423_ChIP-Seq_EOC_Human2.23443617
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21199653
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18780669
23LXR_22292898_ChIP-Seq_THP-1_Human2.18098678
24* VDR_23849224_ChIP-Seq_CD4+_Human2.15948906
25MYC_22102868_ChIP-Seq_BL_Human2.12649855
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.11214020
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11057857
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04196906
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03023063
30* TET1_21451524_ChIP-Seq_MESCs_Mouse1.99526793
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98573178
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.93461250
33P68_20966046_ChIP-Seq_HELA_Human1.93353661
34FOXP3_21729870_ChIP-Seq_TREG_Human1.92635189
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90724110
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86249148
37* TTF2_22483619_ChIP-Seq_HELA_Human1.82694005
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.75822326
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75530911
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74903429
41VDR_21846776_ChIP-Seq_THP-1_Human1.73992092
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73128995
43DCP1A_22483619_ChIP-Seq_HELA_Human1.71640134
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68716561
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64524633
46* GABP_19822575_ChIP-Seq_HepG2_Human1.64290819
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62427599
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62309858
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.62230794
50CTCF_27219007_Chip-Seq_Bcells_Human1.61431820
51SCL_19346495_ChIP-Seq_HPC-7_Human1.61070118
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.58688073
53* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58324511
54CIITA_25753668_ChIP-Seq_RAJI_Human1.57352813
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.57176663
56BCL6_27268052_Chip-Seq_Bcells_Human1.56732173
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56243824
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55223590
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55159401
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55074216
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.51166640
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49554420
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49396264
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48497986
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.48406495
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47548005
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46969017
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.46434022
69ELK1_19687146_ChIP-ChIP_HELA_Human1.43520401
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43054897
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.42919454
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42410794
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42384830
74KDM2B_26808549_Chip-Seq_DND41_Human1.40664504
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40024486
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39851842
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39761673
78SMC4_20622854_ChIP-Seq_HELA_Human1.37200656
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36673945
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.32176102
81* SPI1_23547873_ChIP-Seq_NB4_Human1.31869362
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31587039
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.30969381
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30597893
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29264553
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.29209259
87E2F1_20622854_ChIP-Seq_HELA_Human1.28704360
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27153163
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.27116309
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27003903
91SA1_27219007_Chip-Seq_Bcells_Human1.25790180
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.25402685
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25307157
94BCOR_27268052_Chip-Seq_Bcells_Human1.25203435
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.25069266
96PHF8_20622854_ChIP-Seq_HELA_Human1.24191371
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.21663018
98RACK7_27058665_Chip-Seq_MCF-7_Human1.21566068
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21422106
100AR_21909140_ChIP-Seq_LNCAP_Human1.20090291
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19936355
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19515089
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18368342
104CTCF_20526341_ChIP-Seq_ESCs_Human1.17542714
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16492545
106KDM5A_27292631_Chip-Seq_BREAST_Human1.14785258
107CTCF_21964334_Chip-Seq_Bcells_Human1.14092722
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13542333
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13492073
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13458243
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13352125
112STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13186963
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13183345
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12675360
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11513126
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11453330
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11205433
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11104005
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10672931
120UTX_26944678_Chip-Seq_JUKART_Human1.10547630
121TFEB_21752829_ChIP-Seq_HELA_Human1.10393337
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09471309
123CREB1_26743006_Chip-Seq_LNCaP_Human1.09141996
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.08704800
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07916062
126MAF_26560356_Chip-Seq_TH1_Human1.05206149
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.05199600
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05028588
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04689516
130* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04406831
131TP63_19390658_ChIP-ChIP_HaCaT_Human1.03487433
132OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03470405
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02950539
134SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02681547
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02514980
136TP53_22127205_ChIP-Seq_IMR90_Human1.02272401
137STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02096068
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01909911
139GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01837193
140ERA_21632823_ChIP-Seq_H3396_Human1.01690663
141DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01006125
142ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00751038
143MYC_18940864_ChIP-ChIP_HL60_Human1.00742841
144OCT4_19829295_ChIP-Seq_ESCs_Human0.99737160
145* KDM2B_26808549_Chip-Seq_JURKAT_Human0.99616952
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99385237
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98411873
148JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98370606
149RUNX1_22412390_ChIP-Seq_EML_Mouse0.97494488
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96642614
151MYB_26560356_Chip-Seq_TH2_Human0.96392936
152VDR_24763502_ChIP-Seq_THP-1_Human0.95727049
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95276904
154MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94831108
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94279570
156MYB_26560356_Chip-Seq_TH1_Human0.92947032
157* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92850452
158MAF_26560356_Chip-Seq_TH2_Human0.92496093
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91298947
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91164586
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87199529
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.86485147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.94732656
2MP0010094_abnormal_chromosome_stability3.25396281
3MP0002653_abnormal_ependyma_morphology3.24632282
4MP0002396_abnormal_hematopoietic_system3.18368499
5MP0004957_abnormal_blastocyst_morpholog3.12063226
6MP0003077_abnormal_cell_cycle3.00527955
7MP0003111_abnormal_nucleus_morphology2.89899901
8MP0008058_abnormal_DNA_repair2.77820514
9MP0009379_abnormal_foot_pigmentation2.66170562
10MP0002163_abnormal_gland_morphology2.65279632
11MP0003136_yellow_coat_color2.59906192
12MP0008789_abnormal_olfactory_epithelium2.55491372
13MP0008057_abnormal_DNA_replication2.50863807
14MP0003763_abnormal_thymus_physiology2.44154366
15MP0008007_abnormal_cellular_replicative2.42084056
16MP0000049_abnormal_middle_ear2.35645992
17MP0005394_taste/olfaction_phenotype2.33867102
18MP0005499_abnormal_olfactory_system2.33867102
19MP0004808_abnormal_hematopoietic_stem2.24818362
20MP0001835_abnormal_antigen_presentation2.17646569
21MP0000490_abnormal_crypts_of2.17364859
22MP0003787_abnormal_imprinting2.16359297
23MP0002249_abnormal_larynx_morphology2.15557171
24MP0000678_abnormal_parathyroid_gland2.15397198
25MP0002160_abnormal_reproductive_system2.00638434
26MP0000685_abnormal_immune_system1.98109335
27MP0005397_hematopoietic_system_phenotyp1.98086132
28MP0001545_abnormal_hematopoietic_system1.98086132
29MP0002398_abnormal_bone_marrow1.84404260
30MP0009333_abnormal_splenocyte_physiolog1.81566414
31MP0005377_hearing/vestibular/ear_phenot1.76301757
32MP0003878_abnormal_ear_physiology1.76301757
33MP0003786_premature_aging1.72310126
34MP0008932_abnormal_embryonic_tissue1.68887447
35MP0006054_spinal_hemorrhage1.67667170
36MP0005671_abnormal_response_to1.66386611
37MP0005174_abnormal_tail_pigmentation1.66348567
38MP0003122_maternal_imprinting1.65937644
39MP0002722_abnormal_immune_system1.62653491
40MP0004858_abnormal_nervous_system1.61633615
41MP0010352_gastrointestinal_tract_polyps1.60008573
42MP0000689_abnormal_spleen_morphology1.59095465
43MP0001800_abnormal_humoral_immune1.58942023
44MP0002019_abnormal_tumor_incidence1.56671319
45MP0000703_abnormal_thymus_morphology1.54582320
46MP0002166_altered_tumor_susceptibility1.53963502
47MP0000350_abnormal_cell_proliferation1.52890259
48MP0009785_altered_susceptibility_to1.52667774
49MP0004142_abnormal_muscle_tone1.50152756
50MP0001730_embryonic_growth_arrest1.47973651
51MP0002429_abnormal_blood_cell1.45890053
52MP0000716_abnormal_immune_system1.44089087
53MP0002420_abnormal_adaptive_immunity1.42240343
54MP0010307_abnormal_tumor_latency1.41654582
55MP0000465_gastrointestinal_hemorrhage1.41067647
56MP0002452_abnormal_antigen_presenting1.40480651
57MP0001873_stomach_inflammation1.40192095
58MP0001819_abnormal_immune_cell1.39516347
59MP0000858_altered_metastatic_potential1.38949669
60MP0000313_abnormal_cell_death1.38831889
61MP0002132_abnormal_respiratory_system1.37841515
62MP0005025_abnormal_response_to1.35247988
63MP0002723_abnormal_immune_serum1.34908598
64MP0001853_heart_inflammation1.34225522
65MP0002405_respiratory_system_inflammati1.31065040
66MP0005075_abnormal_melanosome_morpholog1.30599015
67MP0002006_tumorigenesis1.29686453
68MP0003123_paternal_imprinting1.27462345
69MP0010155_abnormal_intestine_physiology1.27450026
70MP0003942_abnormal_urinary_system1.27320809
71MP0009053_abnormal_anal_canal1.27269046
72MP0005389_reproductive_system_phenotype1.25597870
73MP0002095_abnormal_skin_pigmentation1.25108660
74MP0005083_abnormal_biliary_tract1.23363342
75MP0005000_abnormal_immune_tolerance1.22452926
76MP0003436_decreased_susceptibility_to1.21783377
77MP0003866_abnormal_defecation1.20419819
78MP0000631_abnormal_neuroendocrine_gland1.19217678
79MP0001986_abnormal_taste_sensitivity1.17764564
80MP0000566_synostosis1.17413217
81MP0002822_catalepsy1.16279497
82MP0003938_abnormal_ear_development1.13184635
83MP0002148_abnormal_hypersensitivity_rea1.12656687
84MP0002080_prenatal_lethality1.11028545
85MP0005464_abnormal_platelet_physiology1.10475817
86MP0001697_abnormal_embryo_size1.06533538
87MP0001968_abnormal_touch/_nociception1.05258869
88MP0003121_genomic_imprinting1.04641938
89MP0001905_abnormal_dopamine_level1.03327770
90MP0001348_abnormal_lacrimal_gland1.02770790
91MP0002116_abnormal_craniofacial_bone1.01754186
92MP0003567_abnormal_fetal_cardiomyocyte1.01638224
93MP0002210_abnormal_sex_determination0.98658384
94MP0005409_darkened_coat_color0.98206188
95MP0005387_immune_system_phenotype0.98199256
96MP0001790_abnormal_immune_system0.98199256
97MP0001663_abnormal_digestive_system0.97702427
98MP0000026_abnormal_inner_ear0.97690021
99MP0009278_abnormal_bone_marrow0.96445580
100MP0002138_abnormal_hepatobiliary_system0.91932212
101MP0001293_anophthalmia0.91727355
102MP0002638_abnormal_pupillary_reflex0.91603083
103MP0002938_white_spotting0.91463381
104MP0005023_abnormal_wound_healing0.91208626
105MP0001145_abnormal_male_reproductive0.90830288
106MP0005380_embryogenesis_phenotype0.90320456
107MP0001672_abnormal_embryogenesis/_devel0.90320456
108MP0005379_endocrine/exocrine_gland_phen0.90092467
109MP0001270_distended_abdomen0.89755134
110MP0001286_abnormal_eye_development0.88366564
111MP0004197_abnormal_fetal_growth/weight/0.87786862
112MP0002086_abnormal_extraembryonic_tissu0.87130538
113MP0006292_abnormal_olfactory_placode0.85815597
114MP0003984_embryonic_growth_retardation0.85628231
115MP0002085_abnormal_embryonic_tissue0.85550721
116MP0001929_abnormal_gametogenesis0.84237556
117MP0002088_abnormal_embryonic_growth/wei0.83663043
118MP0000477_abnormal_intestine_morphology0.83461698
119MP0001485_abnormal_pinna_reflex0.83363755
120MP0001845_abnormal_inflammatory_respons0.82868212
121MP0003186_abnormal_redox_activity0.82710363
122MP0008877_abnormal_DNA_methylation0.80901908
123MP0000778_abnormal_nervous_system0.80116250
124MP0003724_increased_susceptibility_to0.79913690
125MP0009250_abnormal_appendicular_skeleto0.79301846
126MP0002233_abnormal_nose_morphology0.79173243
127MP0003315_abnormal_perineum_morphology0.78566493
128MP0004381_abnormal_hair_follicle0.78292695
129MP0002419_abnormal_innate_immunity0.78233801
130MP0002932_abnormal_joint_morphology0.76831652
131MP0003879_abnormal_hair_cell0.76200939
132MP0000613_abnormal_salivary_gland0.75113358
133MP0010030_abnormal_orbit_morphology0.75033220
134MP0003941_abnormal_skin_development0.74875039
135MP0002933_joint_inflammation0.74373865
136MP0002084_abnormal_developmental_patter0.74312915
137MP0000653_abnormal_sex_gland0.74135282
138MP0000681_abnormal_thyroid_gland0.73596697
139MP0005501_abnormal_skin_physiology0.73513686
140MP0004947_skin_inflammation0.73307832
141MP0003755_abnormal_palate_morphology0.72782184
142MP0005381_digestive/alimentary_phenotyp0.72401712
143MP0006276_abnormal_autonomic_nervous0.72077158
144MP0000358_abnormal_cell_content/0.71605307
145MP0002102_abnormal_ear_morphology0.70664353
146MP0001919_abnormal_reproductive_system0.69721378
147MP0005195_abnormal_posterior_eye0.67849934
148MP0002092_abnormal_eye_morphology0.67729824
149MP0002277_abnormal_respiratory_mucosa0.67112243
150MP0002234_abnormal_pharynx_morphology0.66639733
151MP0003646_muscle_fatigue0.66131069
152MP0002752_abnormal_somatic_nervous0.65937092
153MP0003943_abnormal_hepatobiliary_system0.65846936
154MP0008995_early_reproductive_senescence0.65264487
155MP0002697_abnormal_eye_size0.65143198
156MP0002111_abnormal_tail_morphology0.64636827
157MP0001529_abnormal_vocalization0.63013615
158MP0001963_abnormal_hearing_physiology0.62690973
159MP0003385_abnormal_body_wall0.62499663
160MP0000762_abnormal_tongue_morphology0.62302066
161MP0000015_abnormal_ear_pigmentation0.61888758
162MP0000534_abnormal_ureter_morphology0.61417016
163MP0001188_hyperpigmentation0.61251463
164MP0005076_abnormal_cell_differentiation0.61229757
165MP0001119_abnormal_female_reproductive0.61137197
166MP0003936_abnormal_reproductive_system0.61076267
167MP0000428_abnormal_craniofacial_morphol0.60653697
168MP0000955_abnormal_spinal_cord0.60057509
169MP0005646_abnormal_pituitary_gland0.58016283
170MP0003806_abnormal_nucleotide_metabolis0.57491610
171MP0000750_abnormal_muscle_regeneration0.57074150
172MP0002837_dystrophic_cardiac_calcinosis0.55390165
173MP0005423_abnormal_somatic_nervous0.54287801
174MP0001502_abnormal_circadian_rhythm0.53596137
175MP0003861_abnormal_nervous_system0.51266919
176MP0002557_abnormal_social/conspecific_i0.51128613
177MP0001346_abnormal_lacrimal_gland0.49524453

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.90308299
2Abnormality of cells of the erythroid lineage (HP:0012130)6.82551936
3Abnormal number of erythroid precursors (HP:0012131)6.52849076
4Thrombocytosis (HP:0001894)4.66316766
5Pallor (HP:0000980)4.63537233
6Aplastic anemia (HP:0001915)4.59117920
7Macrocytic anemia (HP:0001972)4.40337504
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.64607777
9Rib fusion (HP:0000902)3.57632038
10Partial duplication of thumb phalanx (HP:0009944)3.52166495
1111 pairs of ribs (HP:0000878)3.49803191
12Colon cancer (HP:0003003)3.45902978
13Partial duplication of the phalanx of hand (HP:0009999)3.29136072
14IgM deficiency (HP:0002850)3.27263699
15Hyperthyroidism (HP:0000836)3.20196608
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19379521
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19379521
18Anomalous pulmonary venous return (HP:0010772)3.15760878
19Septo-optic dysplasia (HP:0100842)3.12816985
20Recurrent bronchitis (HP:0002837)3.03286228
21Chronic otitis media (HP:0000389)2.99766639
22Poikiloderma (HP:0001029)2.93670485
23Oral leukoplakia (HP:0002745)2.92047057
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82897094
25Elevated erythrocyte sedimentation rate (HP:0003565)2.80424953
26Abnormal mitochondria in muscle tissue (HP:0008316)2.74573536
27Acute necrotizing encephalopathy (HP:0006965)2.72148879
28Thoracic kyphosis (HP:0002942)2.70544567
29Abnormality of the pulmonary veins (HP:0011718)2.66105625
30Selective tooth agenesis (HP:0001592)2.65798605
31Nasal polyposis (HP:0100582)2.62765588
32Myelodysplasia (HP:0002863)2.62116517
33Absent thumb (HP:0009777)2.58977299
34Duplication of thumb phalanx (HP:0009942)2.58054723
35Birth length less than 3rd percentile (HP:0003561)2.56839870
36Mitochondrial inheritance (HP:0001427)2.55404417
37Abnormality of reticulocytes (HP:0004312)2.53190580
38Abnormality of the nasal mucosa (HP:0000433)2.49257769
39Abnormal rod and cone electroretinograms (HP:0008323)2.47066001
40Pancreatic fibrosis (HP:0100732)2.45978864
41Abnormality of DNA repair (HP:0003254)2.45839769
42Petechiae (HP:0000967)2.45181250
43Chromsome breakage (HP:0040012)2.43967529
44Muscle fiber atrophy (HP:0100295)2.41112074
45Hepatocellular necrosis (HP:0001404)2.36901681
46Increased muscle lipid content (HP:0009058)2.36289477
47Medulloblastoma (HP:0002885)2.35499998
48Acute encephalopathy (HP:0006846)2.34289806
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.33669971
50Abnormality of the 4th metacarpal (HP:0010012)2.31905614
51Type I transferrin isoform profile (HP:0003642)2.31497377
52Rectal prolapse (HP:0002035)2.30523656
53Microretrognathia (HP:0000308)2.30117338
54Abnormality of the aortic arch (HP:0012303)2.29193842
55Maternal diabetes (HP:0009800)2.28801095
56Ependymoma (HP:0002888)2.27149523
57Horseshoe kidney (HP:0000085)2.26965790
58Ectopic kidney (HP:0000086)2.26777957
59Progressive muscle weakness (HP:0003323)2.26226190
60Increased intramyocellular lipid droplets (HP:0012240)2.25653295
61Entropion (HP:0000621)2.23014676
62Abnormality of T cell physiology (HP:0011840)2.22150281
63Broad distal phalanx of finger (HP:0009836)2.21362489
64Forearm undergrowth (HP:0009821)2.21007188
65Prolonged bleeding time (HP:0003010)2.20765287
66Pancytopenia (HP:0001876)2.20631679
67Deep palmar crease (HP:0006191)2.20148735
68Truncus arteriosus (HP:0001660)2.19722146
69Severe visual impairment (HP:0001141)2.18820254
70Amaurosis fugax (HP:0100576)2.18627439
71Abnormality of chromosome stability (HP:0003220)2.18478598
72Lymphoma (HP:0002665)2.17149551
73Annular pancreas (HP:0001734)2.16092891
74Missing ribs (HP:0000921)2.15353198
75Abnormality of the preputium (HP:0100587)2.15310732
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14031985
77Rough bone trabeculation (HP:0100670)2.13154134
78Abnormality of the thoracic spine (HP:0100711)2.12688906
79Depressed nasal ridge (HP:0000457)2.11991799
80Short femoral neck (HP:0100864)2.11966808
81Porencephaly (HP:0002132)2.11804610
82High anterior hairline (HP:0009890)2.11051324
83Myositis (HP:0100614)2.09321322
84Basal cell carcinoma (HP:0002671)2.08384958
85Type 2 muscle fiber atrophy (HP:0003554)2.08100202
86Facial hemangioma (HP:0000329)2.07282606
87Premature graying of hair (HP:0002216)2.06399165
88Molar tooth sign on MRI (HP:0002419)2.05593212
89Abnormality of midbrain morphology (HP:0002418)2.05593212
90IgG deficiency (HP:0004315)2.03589817
91Triphalangeal thumb (HP:0001199)2.02851819
92Bronchitis (HP:0012387)2.01963703
93Meckel diverticulum (HP:0002245)2.01228270
94Neoplasm of the pancreas (HP:0002894)2.01143231
95Asplenia (HP:0001746)1.99491092
96Abnormality of T cells (HP:0002843)1.99372808
97Acute lymphatic leukemia (HP:0006721)1.98533158
98Increased CSF lactate (HP:0002490)1.97987483
99Cystic liver disease (HP:0006706)1.95391139
100Trismus (HP:0000211)1.95124233
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93921432
102Abnormality of the ileum (HP:0001549)1.93691279
103Panhypogammaglobulinemia (HP:0003139)1.93088275
104Sclerocornea (HP:0000647)1.91155646
105Patellar aplasia (HP:0006443)1.91108794
106Holoprosencephaly (HP:0001360)1.90568913
107Bone marrow hypocellularity (HP:0005528)1.88430710
108Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87889911
109Progressive macrocephaly (HP:0004481)1.87260743
110Carpal bone hypoplasia (HP:0001498)1.87020822
111Pendular nystagmus (HP:0012043)1.85466272
112Hepatic necrosis (HP:0002605)1.85012205
113Anophthalmia (HP:0000528)1.84652559
114Poor head control (HP:0002421)1.84552452
115Abnormality of B cell number (HP:0010975)1.84180416
116B lymphocytopenia (HP:0010976)1.84180416
117Renal dysplasia (HP:0000110)1.83580020
118True hermaphroditism (HP:0010459)1.81071967
119Agnosia (HP:0010524)1.80872883
120Oligodactyly (HP:0012165)1.80144642
121Pancreatic cysts (HP:0001737)1.79770767
122Abnormal protein glycosylation (HP:0012346)1.79665531
123Abnormal glycosylation (HP:0012345)1.79665531
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79665531
125Abnormal protein N-linked glycosylation (HP:0012347)1.79665531
126Abnormality of the parietal bone (HP:0002696)1.79560286
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.78921243
128Optic nerve coloboma (HP:0000588)1.78793827
129Squamous cell carcinoma (HP:0002860)1.78458732
130Hypoplasia of the radius (HP:0002984)1.77946406
131Migraine (HP:0002076)1.77876953
132Degeneration of anterior horn cells (HP:0002398)1.77142973
133Abnormality of the anterior horn cell (HP:0006802)1.77142973
134Diastasis recti (HP:0001540)1.77091072
135Aplasia/Hypoplasia of the patella (HP:0006498)1.77024724
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.76466872
137Recurrent viral infections (HP:0004429)1.75831555
138Flat capital femoral epiphysis (HP:0003370)1.75341487
139Thick lower lip vermilion (HP:0000179)1.75196221
140Anencephaly (HP:0002323)1.74382508
141Duodenal stenosis (HP:0100867)1.74203601
142Small intestinal stenosis (HP:0012848)1.74203601
143Cleft eyelid (HP:0000625)1.73409795
144Hyperglycinemia (HP:0002154)1.73348783
145Hypoplasia of the ulna (HP:0003022)1.73125857
146Tracheoesophageal fistula (HP:0002575)1.73104482
147Multiple enchondromatosis (HP:0005701)1.70630592
148Lipid accumulation in hepatocytes (HP:0006561)1.70031006
149Short thumb (HP:0009778)1.69897483
150Breast hypoplasia (HP:0003187)1.68913979
151Tongue fasciculations (HP:0001308)1.68632312
152Premature ovarian failure (HP:0008209)1.67711522
153Abnormal number of incisors (HP:0011064)1.67576520
154Gonadotropin excess (HP:0000837)1.67375054
155Abnormality of cochlea (HP:0000375)1.66732327
156Tetralogy of Fallot (HP:0001636)1.64416373
157Pulmonary fibrosis (HP:0002206)1.63115766
158Chronic sinusitis (HP:0011109)1.62751372
159Abnormality of cells of the lymphoid lineage (HP:0012140)1.62739810
160Abnormal hemoglobin (HP:0011902)1.62553625
161Abnormality of the diencephalon (HP:0010662)1.61155760
162Cellulitis (HP:0100658)1.60788765
163Adrenal hypoplasia (HP:0000835)1.60117360
164Hypertensive crisis (HP:0100735)1.59768641
165Type II lissencephaly (HP:0007260)1.59336038
166Lymphopenia (HP:0001888)1.56628301
167Abnormality of the renal collecting system (HP:0004742)1.55392751
168Chronic obstructive pulmonary disease (HP:0006510)1.55126919
169Obstructive lung disease (HP:0006536)1.55126919
170Agammaglobulinemia (HP:0004432)1.54430949
171Clubbing of toes (HP:0100760)1.53051923
172Abnormality of the intervertebral disk (HP:0005108)1.52913462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.98907233
2WEE13.43369657
3STK162.78760388
4EIF2AK12.77818721
5BUB12.73175999
6TLK12.62605192
7EEF2K2.52339418
8MAP4K12.51083557
9RPS6KA42.45932758
10ACVR1B2.45130913
11TGFBR12.32502773
12RPS6KB22.26875978
13ARAF2.05815744
14CDC72.02904279
15FLT31.91685214
16EIF2AK31.90738889
17VRK11.83837194
18PIM21.80516908
19DYRK31.78728086
20EPHB21.72515820
21NEK21.71481252
22MARK21.68699801
23PASK1.68670969
24SRPK11.66518550
25LRRK21.66333448
26WNK41.63722340
27BRAF1.59640854
28TYRO31.53597989
29BTK1.51624824
30KDR1.51339319
31SCYL21.50020655
32TESK21.49174124
33BRSK21.49144013
34ICK1.47018747
35CDK71.44978567
36PKN21.44749035
37DYRK21.41510767
38MAP3K111.41256557
39SIK11.40868119
40KIT1.37689172
41TRIB31.35552903
42TEC1.31540957
43ZAP701.31414103
44ATR1.28744327
45MAP2K21.28394821
46DAPK31.21822403
47AURKB1.21199278
48MAP3K101.20769750
49ABL21.20549020
50PAK41.20430426
51PIK3CA1.20260314
52MAPKAPK31.18394300
53MKNK11.17105280
54STK101.12243394
55STK111.11712132
56MARK31.11671912
57TSSK61.11661590
58BRSK11.11640556
59CDK41.10603761
60MAPK151.10157915
61PLK41.09831565
62MAP3K131.07338629
63PIM11.05772671
64PRKD21.05488705
65CAMK11.04247323
66PLK11.03931426
67MAP3K81.03655566
68SMG11.02937239
69PRKD31.02107807
70MAP3K90.97262593
71JAK30.97030765
72CDK190.97025199
73TXK0.95903446
74NTRK20.95196138
75ZAK0.95063157
76VRK20.93381462
77RPS6KA50.92673363
78TYK20.92509307
79MAP2K30.88979564
80MKNK20.88643810
81DYRK1B0.86907345
82ILK0.86124286
83HIPK20.84807712
84STK40.84022245
85CDC42BPA0.82374229
86CSF1R0.81829396
87CAMKK10.81264510
88PRKCQ0.81214670
89BLK0.77917848
90TBK10.76552176
91TTK0.74991733
92IKBKB0.73948965
93CHEK20.70150512
94PINK10.69615238
95RPS6KA20.68830151
96TGFBR20.68385241
97MAP3K70.67984515
98AURKA0.67633256
99TIE10.67254744
100TESK10.66054124
101SYK0.64416112
102MTOR0.64364912
103BCKDK0.63318894
104CAMK40.63301914
105MAP2K70.61980322
106CDK120.61067425
107PRKCH0.59781656
108IRAK40.59607397
109ADRBK20.57813429
110IKBKE0.56984915
111ITK0.56626698
112ERN10.56264708
113EIF2AK20.55805220
114MOS0.55324486
115CSNK2A20.53944357
116DMPK0.53592383
117NEK10.53498881
118AKT20.53161084
119LIMK10.52727819
120* CHEK10.52493538
121EPHA20.51559819
122LYN0.51026877
123PRKCI0.50842067
124MAPK120.50730173
125AKT10.48998661
126PRPF4B0.48940017
127EPHA40.48738081
128NLK0.48515831
129CSNK2A10.48334559
130CCNB10.48226020
131MATK0.47795487
132CDK80.47651417
133RPS6KA10.47366436
134LCK0.46486201
135ADRBK10.45785297
136FES0.45749046
137PAK20.45256522
138PAK10.45082330
139RPS6KA60.44844544
140ATM0.43269552
141RPS6KC10.41602346
142RPS6KL10.41602346
143PRKCD0.40994608
144CDK60.40403784
145GRK10.39973488
146GRK60.39929281
147PRKG20.39648277
148CDK20.37812790
149PBK0.37810691
150MAPKAPK20.36475705
151PDK40.34019558
152PDK30.34019558
153MAP2K60.33578038
154MAP3K30.32899067

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.99783694
2DNA replication_Homo sapiens_hsa030304.52686453
3Mismatch repair_Homo sapiens_hsa034303.72859553
4Spliceosome_Homo sapiens_hsa030403.07225522
5Base excision repair_Homo sapiens_hsa034102.78526971
6Homologous recombination_Homo sapiens_hsa034402.72933634
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68410156
8Oxidative phosphorylation_Homo sapiens_hsa001902.66466264
9RNA polymerase_Homo sapiens_hsa030202.64660817
10Proteasome_Homo sapiens_hsa030502.56002706
11Nucleotide excision repair_Homo sapiens_hsa034202.55107150
12Pyrimidine metabolism_Homo sapiens_hsa002402.32955534
13RNA transport_Homo sapiens_hsa030132.24076753
14Cell cycle_Homo sapiens_hsa041101.88277954
15Fanconi anemia pathway_Homo sapiens_hsa034601.87152929
16One carbon pool by folate_Homo sapiens_hsa006701.83738098
17Systemic lupus erythematosus_Homo sapiens_hsa053221.78751152
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77428441
19Primary immunodeficiency_Homo sapiens_hsa053401.73640242
20Non-homologous end-joining_Homo sapiens_hsa034501.72187504
21RNA degradation_Homo sapiens_hsa030181.60530736
22Cardiac muscle contraction_Homo sapiens_hsa042601.60076051
23Alzheimers disease_Homo sapiens_hsa050101.58366855
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54952479
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53635614
26Basal transcription factors_Homo sapiens_hsa030221.53143703
27p53 signaling pathway_Homo sapiens_hsa041151.49949226
28Basal cell carcinoma_Homo sapiens_hsa052171.47515541
29Antigen processing and presentation_Homo sapiens_hsa046121.39554504
30Herpes simplex infection_Homo sapiens_hsa051681.29519333
31Hedgehog signaling pathway_Homo sapiens_hsa043401.20210778
32Purine metabolism_Homo sapiens_hsa002301.17703988
33Protein export_Homo sapiens_hsa030601.12868307
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11793925
35Pentose phosphate pathway_Homo sapiens_hsa000301.11726658
36Epstein-Barr virus infection_Homo sapiens_hsa051691.05779478
37mRNA surveillance pathway_Homo sapiens_hsa030151.00617442
38Viral carcinogenesis_Homo sapiens_hsa052030.99555217
39Linoleic acid metabolism_Homo sapiens_hsa005910.95560292
40Measles_Homo sapiens_hsa051620.92368805
41Hematopoietic cell lineage_Homo sapiens_hsa046400.91086294
42Sulfur relay system_Homo sapiens_hsa041220.90904641
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89998479
44N-Glycan biosynthesis_Homo sapiens_hsa005100.89233273
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.84967386
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83628427
47Arachidonic acid metabolism_Homo sapiens_hsa005900.83551855
48Folate biosynthesis_Homo sapiens_hsa007900.83336531
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80352375
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80283955
51Legionellosis_Homo sapiens_hsa051340.76552292
52Fat digestion and absorption_Homo sapiens_hsa049750.75594510
53HTLV-I infection_Homo sapiens_hsa051660.74698206
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.73383479
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72815415
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66882034
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.66826615
58Alcoholism_Homo sapiens_hsa050340.65027627
59Thyroid cancer_Homo sapiens_hsa052160.64474357
60Shigellosis_Homo sapiens_hsa051310.63868956
61Apoptosis_Homo sapiens_hsa042100.63760088
62VEGF signaling pathway_Homo sapiens_hsa043700.63217502
63B cell receptor signaling pathway_Homo sapiens_hsa046620.62409552
64Acute myeloid leukemia_Homo sapiens_hsa052210.62369184
65Leishmaniasis_Homo sapiens_hsa051400.61476925
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.60605931
67Small cell lung cancer_Homo sapiens_hsa052220.59640384
68Hippo signaling pathway_Homo sapiens_hsa043900.58786921
69Huntingtons disease_Homo sapiens_hsa050160.57318903
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.55028233
71Selenocompound metabolism_Homo sapiens_hsa004500.53291740
72Hepatitis B_Homo sapiens_hsa051610.52737718
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52646282
74Biosynthesis of amino acids_Homo sapiens_hsa012300.51924467
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51633156
76Allograft rejection_Homo sapiens_hsa053300.50188449
77Influenza A_Homo sapiens_hsa051640.49800865
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49681971
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47397481
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.46741767
81Melanoma_Homo sapiens_hsa052180.46391227
82Notch signaling pathway_Homo sapiens_hsa043300.45793988
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44836369
84Melanogenesis_Homo sapiens_hsa049160.44549079
85Galactose metabolism_Homo sapiens_hsa000520.44541338
86Chronic myeloid leukemia_Homo sapiens_hsa052200.43881169
87Parkinsons disease_Homo sapiens_hsa050120.42798360
88Asthma_Homo sapiens_hsa053100.42477029
89Metabolic pathways_Homo sapiens_hsa011000.42394197
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42075432
91Non-small cell lung cancer_Homo sapiens_hsa052230.41576707
92Glutathione metabolism_Homo sapiens_hsa004800.39834949
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39375995
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38673684
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38504885
96T cell receptor signaling pathway_Homo sapiens_hsa046600.38166573
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37657900
98Other glycan degradation_Homo sapiens_hsa005110.36980625
99Wnt signaling pathway_Homo sapiens_hsa043100.36365894
100Olfactory transduction_Homo sapiens_hsa047400.35683359
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35523037
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35107035
103Tyrosine metabolism_Homo sapiens_hsa003500.34306696
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34089752
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33889847
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32990053
107Toxoplasmosis_Homo sapiens_hsa051450.32488633
108Renin-angiotensin system_Homo sapiens_hsa046140.32329475
109Bladder cancer_Homo sapiens_hsa052190.32130479
110MicroRNAs in cancer_Homo sapiens_hsa052060.31933343
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30344734
112HIF-1 signaling pathway_Homo sapiens_hsa040660.28681539
113Platelet activation_Homo sapiens_hsa046110.27507898
114Colorectal cancer_Homo sapiens_hsa052100.27004760
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26965493
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26842204
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.26725106
118Malaria_Homo sapiens_hsa051440.26594867
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26571789
120Autoimmune thyroid disease_Homo sapiens_hsa053200.26107735
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24894922
122Axon guidance_Homo sapiens_hsa043600.24453248
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24451243
124Osteoclast differentiation_Homo sapiens_hsa043800.23750814
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23609860
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23578856
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23355212
128Peroxisome_Homo sapiens_hsa041460.23259404
129Pathways in cancer_Homo sapiens_hsa052000.22586034
130Viral myocarditis_Homo sapiens_hsa054160.22451223
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22024227
132mTOR signaling pathway_Homo sapiens_hsa041500.20718771
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.19489369
134Ovarian steroidogenesis_Homo sapiens_hsa049130.18003317
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.17653119
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17188184
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17170383
138Phenylalanine metabolism_Homo sapiens_hsa003600.16283819
139Chemical carcinogenesis_Homo sapiens_hsa052040.14225522
140Endometrial cancer_Homo sapiens_hsa052130.12982384
141Ras signaling pathway_Homo sapiens_hsa040140.11799428
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.11755430
143Graft-versus-host disease_Homo sapiens_hsa053320.10550805
144Rap1 signaling pathway_Homo sapiens_hsa040150.09971562

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