RPL13A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)8.70630981
2* translational termination (GO:0006415)8.36131031
3ribosomal small subunit assembly (GO:0000028)8.31952192
4ribosomal small subunit biogenesis (GO:0042274)7.46301771
5* translational elongation (GO:0006414)7.28334608
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.92112226
7maturation of SSU-rRNA (GO:0030490)6.88328503
8* protein targeting to ER (GO:0045047)6.77082775
9* cotranslational protein targeting to membrane (GO:0006613)6.75437515
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.69400170
11* cellular protein complex disassembly (GO:0043624)6.50240339
12* viral life cycle (GO:0019058)6.49399636
13* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.47051207
14* translational initiation (GO:0006413)6.42008900
15* protein localization to endoplasmic reticulum (GO:0070972)6.29225358
16* protein complex disassembly (GO:0043241)5.83738209
17ribosomal large subunit biogenesis (GO:0042273)5.77700078
18* macromolecular complex disassembly (GO:0032984)5.44620985
19* nuclear-transcribed mRNA catabolic process (GO:0000956)4.81901670
20* mRNA catabolic process (GO:0006402)4.57379523
21ribonucleoprotein complex biogenesis (GO:0022613)4.51245404
22* protein targeting to membrane (GO:0006612)4.50404905
23formation of translation preinitiation complex (GO:0001731)4.39666606
24* RNA catabolic process (GO:0006401)4.36188716
25* translation (GO:0006412)4.30369280
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06346275
27DNA unwinding involved in DNA replication (GO:0006268)4.05732522
28* protein localization to membrane (GO:0072657)4.03798038
29ATP synthesis coupled proton transport (GO:0015986)4.02662112
30energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02662112
31ncRNA 3-end processing (GO:0043628)3.90474409
32DNA strand elongation involved in DNA replication (GO:0006271)3.80282503
33DNA deamination (GO:0045006)3.67750245
34rRNA processing (GO:0006364)3.64212826
35DNA strand elongation (GO:0022616)3.58762516
36rRNA metabolic process (GO:0016072)3.52336846
37telomere maintenance via semi-conservative replication (GO:0032201)3.44322964
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.42535024
39negative regulation of RNA splicing (GO:0033119)3.36918735
40DNA replication initiation (GO:0006270)3.36684139
41folic acid-containing compound biosynthetic process (GO:0009396)3.31032340
42protein localization to kinetochore (GO:0034501)3.27749599
43* protein localization to organelle (GO:0033365)3.16728868
44spliceosomal snRNP assembly (GO:0000387)3.15736380
45DNA replication checkpoint (GO:0000076)3.15114016
46cellular component biogenesis (GO:0044085)3.06212249
47DNA replication-dependent nucleosome assembly (GO:0006335)3.01755254
48DNA replication-dependent nucleosome organization (GO:0034723)3.01755254
49mitotic nuclear envelope disassembly (GO:0007077)3.01611038
50* establishment of protein localization to membrane (GO:0090150)3.00718092
51spliceosomal complex assembly (GO:0000245)3.00334419
52ribosome biogenesis (GO:0042254)2.99232685
53telomere maintenance via recombination (GO:0000722)2.95605871
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95558320
55mitotic recombination (GO:0006312)2.94239483
56nucleobase biosynthetic process (GO:0046112)2.90584572
57heterochromatin organization (GO:0070828)2.89479492
58protein localization to chromosome, centromeric region (GO:0071459)2.84197651
59* establishment of protein localization to organelle (GO:0072594)2.84049185
60telomere maintenance via telomere lengthening (GO:0010833)2.77720408
61membrane disassembly (GO:0030397)2.76803496
62nuclear envelope disassembly (GO:0051081)2.76803496
63RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74879532
64mRNA splicing, via spliceosome (GO:0000398)2.74879532
65IMP biosynthetic process (GO:0006188)2.74212760
66inner mitochondrial membrane organization (GO:0007007)2.73993369
67RNA splicing, via transesterification reactions (GO:0000375)2.73323672
68nucleotide-excision repair, DNA gap filling (GO:0006297)2.72754801
69* protein targeting (GO:0006605)2.72053669
70ribosome assembly (GO:0042255)2.71477887
71DNA duplex unwinding (GO:0032508)2.69339295
72DNA geometric change (GO:0032392)2.65926917
73chromatin remodeling at centromere (GO:0031055)2.62096293
74ribonucleoprotein complex assembly (GO:0022618)2.61156521
75mitotic metaphase plate congression (GO:0007080)2.60175408
76* gene expression (GO:0010467)2.59491901
77* cellular component disassembly (GO:0022411)2.58639459
78myeloid cell homeostasis (GO:0002262)2.57827071
79regulation of histone H3-K9 methylation (GO:0051570)2.57402765
80termination of RNA polymerase II transcription (GO:0006369)2.56000521
81pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54033759
82regulation of posttranscriptional gene silencing (GO:0060147)2.52380617
83regulation of gene silencing by miRNA (GO:0060964)2.52380617
84regulation of gene silencing by RNA (GO:0060966)2.52380617
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52335697
86chromatin assembly or disassembly (GO:0006333)2.51949331
87establishment of integrated proviral latency (GO:0075713)2.51655661
88regulation of mitochondrial translation (GO:0070129)2.51419953
89regulation of protein heterodimerization activity (GO:0043497)2.51124777
90negative regulation of mRNA processing (GO:0050686)2.50571067
91CENP-A containing nucleosome assembly (GO:0034080)2.50025223
92ncRNA processing (GO:0034470)2.49831078
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49692745
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49692745
95DNA replication-independent nucleosome assembly (GO:0006336)2.49113291
96DNA replication-independent nucleosome organization (GO:0034724)2.49113291
97regulation of translational fidelity (GO:0006450)2.47206031
98ribonucleoprotein complex subunit organization (GO:0071826)2.47199270
99purine nucleobase biosynthetic process (GO:0009113)2.46014660
100mitotic chromosome condensation (GO:0007076)2.45500383
101chaperone-mediated protein transport (GO:0072321)2.43210288
102respiratory electron transport chain (GO:0022904)2.42645440
103chromatin assembly (GO:0031497)2.41671981
104negative regulation of histone methylation (GO:0031061)2.41574057
105kinetochore organization (GO:0051383)2.41469532
106transcription-coupled nucleotide-excision repair (GO:0006283)2.41283665
107IMP metabolic process (GO:0046040)2.41236427
108nuclear pore organization (GO:0006999)2.40564995
109pseudouridine synthesis (GO:0001522)2.39776975
110tongue development (GO:0043586)2.38529022
111electron transport chain (GO:0022900)2.38198286
112regulation of spindle organization (GO:0090224)2.37661481
113viral mRNA export from host cell nucleus (GO:0046784)2.35550527
114negative regulation of DNA repair (GO:0045738)2.34520103
115intra-S DNA damage checkpoint (GO:0031573)2.34384762
116pyrimidine nucleotide catabolic process (GO:0006244)2.31691242
117viral protein processing (GO:0019082)2.30642024
118T cell apoptotic process (GO:0070231)2.29561269
119UTP biosynthetic process (GO:0006228)2.29527068
120thymic T cell selection (GO:0045061)2.29097439
121positive thymic T cell selection (GO:0045059)2.26158046
122* single-organism cellular localization (GO:1902580)2.25274772
123negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.19119787
124positive regulation by host of viral transcription (GO:0043923)2.15526264
125negative regulation of DNA-templated transcription, elongation (GO:0032785)2.10595085
126positive regulation of viral transcription (GO:0050434)2.10179998
127oxidative phosphorylation (GO:0006119)2.09104853
128negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.08802914
129GTP biosynthetic process (GO:0006183)2.06433413
130DNA topological change (GO:0006265)2.06331481
131guanosine-containing compound biosynthetic process (GO:1901070)2.06146392
132purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.06100799
133ATP biosynthetic process (GO:0006754)2.05995762
134UTP metabolic process (GO:0046051)2.05939416
135regulation of chromatin binding (GO:0035561)2.04948375
136ribonucleoside triphosphate biosynthetic process (GO:0009201)2.02879108
137purine nucleoside triphosphate biosynthetic process (GO:0009145)2.00699561
138pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)1.96299505
139negative T cell selection (GO:0043383)1.94561493
140negative thymic T cell selection (GO:0045060)1.93516986
141V(D)J recombination (GO:0033151)1.92777606
142innate immune response in mucosa (GO:0002227)1.92518510
143pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)1.92069894
144regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.91332740
145pyrimidine nucleoside triphosphate metabolic process (GO:0009147)1.90074884
146ncRNA metabolic process (GO:0034660)1.88777294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84307419
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.25102031
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85728493
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.37520379
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27692795
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84209969
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74232039
8MYC_22102868_ChIP-Seq_BL_Human2.61550934
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57468697
10* XRN2_22483619_ChIP-Seq_HELA_Human2.57031817
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56476258
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55919674
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.54111293
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.44943529
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.35010830
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25311900
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15884172
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.14717266
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11485294
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03162045
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02855630
22* VDR_23849224_ChIP-Seq_CD4+_Human1.99486109
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97710843
24VDR_21846776_ChIP-Seq_THP-1_Human1.97436229
25TTF2_22483619_ChIP-Seq_HELA_Human1.91459744
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89563057
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89386373
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88488116
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83331164
30FOXP3_21729870_ChIP-Seq_TREG_Human1.81149300
31* CIITA_25753668_ChIP-Seq_RAJI_Human1.72381910
32* DCP1A_22483619_ChIP-Seq_HELA_Human1.72187226
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69375297
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64469940
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63388879
36* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62709109
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.58489065
38GABP_19822575_ChIP-Seq_HepG2_Human1.57515272
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53189584
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52494169
41* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46604730
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44418165
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44157011
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.43179395
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41000713
46* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40265803
47ELK1_19687146_ChIP-ChIP_HELA_Human1.39504765
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39489128
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38526237
50KDM5A_27292631_Chip-Seq_BREAST_Human1.37777741
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37466602
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36811168
53AR_21909140_ChIP-Seq_LNCAP_Human1.36359228
54LXR_22292898_ChIP-Seq_THP-1_Human1.36228424
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35850005
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34763953
57* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34518442
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34467960
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33727267
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33298136
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33126545
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31452151
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.30509806
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28379607
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28300538
66UTX_26944678_Chip-Seq_JUKART_Human1.27368076
67* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26090455
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25854607
69MAF_26560356_Chip-Seq_TH1_Human1.23751674
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22335760
71* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21696457
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20190085
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.20012449
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19381263
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19381263
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19381263
77* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18395541
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16303790
79P68_20966046_ChIP-Seq_HELA_Human1.16228605
80* YY1_21170310_ChIP-Seq_MESCs_Mouse1.15072227
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15038822
82* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14341839
83MAF_26560356_Chip-Seq_TH2_Human1.13560590
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13357717
85KDM2B_26808549_Chip-Seq_DND41_Human1.12647264
86* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11624287
87SPI1_23547873_ChIP-Seq_NB4_Human1.08906496
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.08129998
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07536527
90RACK7_27058665_Chip-Seq_MCF-7_Human1.07282796
91CTCF_26484167_Chip-Seq_Bcells_Mouse1.06939500
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06672310
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06470159
94TFEB_21752829_ChIP-Seq_HELA_Human1.05630074
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.05213105
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04781939
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03935454
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03695974
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01904275
100TCF7_22412390_ChIP-Seq_EML_Mouse1.01865486
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.01840098
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01533268
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00966304
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99794667
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99672210
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99514606
107MYC_18940864_ChIP-ChIP_HL60_Human0.98710965
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98529963
109TP63_19390658_ChIP-ChIP_HaCaT_Human0.97417030
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97312188
111YY1_22570637_ChIP-Seq_MALME-3M_Human0.96442936
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95758895
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95329518
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95227219
115* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94737329
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.94339931
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93782090
118MYB_26560356_Chip-Seq_TH2_Human0.93454349
119VDR_24763502_ChIP-Seq_THP-1_Human0.93308522
120MYB_26560356_Chip-Seq_TH1_Human0.92141600
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91906963
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91071444
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90292454
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90185854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.29378750
2MP0004957_abnormal_blastocyst_morpholog3.77781556
3MP0006292_abnormal_olfactory_placode3.62920713
4MP0003111_abnormal_nucleus_morphology3.36289862
5MP0003077_abnormal_cell_cycle3.15890076
6MP0010094_abnormal_chromosome_stability3.15450656
7MP0000566_synostosis3.06783230
8MP0003136_yellow_coat_color2.74414043
9MP0009379_abnormal_foot_pigmentation2.49028847
10MP0002396_abnormal_hematopoietic_system2.41085285
11MP0010352_gastrointestinal_tract_polyps2.38186659
12MP0003763_abnormal_thymus_physiology2.35869976
13MP0008007_abnormal_cellular_replicative2.11618940
14MP0008058_abnormal_DNA_repair2.06918117
15MP0008057_abnormal_DNA_replication2.02815537
16MP0008932_abnormal_embryonic_tissue1.97769563
17MP0001730_embryonic_growth_arrest1.94902382
18MP0000350_abnormal_cell_proliferation1.94131525
19MP0000490_abnormal_crypts_of1.91993367
20MP0009333_abnormal_splenocyte_physiolog1.89275634
21MP0004808_abnormal_hematopoietic_stem1.88046180
22MP0008995_early_reproductive_senescence1.82279154
23MP0000703_abnormal_thymus_morphology1.72138180
24MP0003123_paternal_imprinting1.70783340
25MP0002398_abnormal_bone_marrow1.67552180
26MP0000685_abnormal_immune_system1.66456565
27MP0002938_white_spotting1.65479555
28MP0001346_abnormal_lacrimal_gland1.58701451
29MP0002722_abnormal_immune_system1.51161553
30MP0003938_abnormal_ear_development1.50295822
31MP0002019_abnormal_tumor_incidence1.49196748
32MP0002249_abnormal_larynx_morphology1.48383401
33MP0001800_abnormal_humoral_immune1.47912821
34MP0005076_abnormal_cell_differentiation1.46768141
35MP0001697_abnormal_embryo_size1.44005152
36MP0002080_prenatal_lethality1.41962952
37MP0002009_preneoplasia1.41629199
38MP0000049_abnormal_middle_ear1.41497952
39MP0000537_abnormal_urethra_morphology1.39571775
40MP0003786_premature_aging1.39077550
41MP0010030_abnormal_orbit_morphology1.38952276
42MP0002163_abnormal_gland_morphology1.38541660
43MP0000689_abnormal_spleen_morphology1.38131172
44MP0010307_abnormal_tumor_latency1.38121994
45MP0002277_abnormal_respiratory_mucosa1.37210869
46MP0001672_abnormal_embryogenesis/_devel1.36778220
47MP0005380_embryogenesis_phenotype1.36778220
48MP0000858_altered_metastatic_potential1.33903853
49MP0002085_abnormal_embryonic_tissue1.32629141
50MP0004197_abnormal_fetal_growth/weight/1.31196282
51MP0004381_abnormal_hair_follicle1.29014180
52MP0002084_abnormal_developmental_patter1.28464713
53MP0002429_abnormal_blood_cell1.27732310
54MP0000313_abnormal_cell_death1.27095650
55MP0000716_abnormal_immune_system1.26696060
56MP0002086_abnormal_extraembryonic_tissu1.24902853
57MP0002166_altered_tumor_susceptibility1.24837293
58MP0003984_embryonic_growth_retardation1.24740213
59MP0002088_abnormal_embryonic_growth/wei1.24036936
60MP0003567_abnormal_fetal_cardiomyocyte1.23437083
61MP0002420_abnormal_adaptive_immunity1.23185351
62MP0003878_abnormal_ear_physiology1.22385510
63MP0005377_hearing/vestibular/ear_phenot1.22385510
64MP0009278_abnormal_bone_marrow1.22005093
65MP0003705_abnormal_hypodermis_morpholog1.21763493
66MP0001819_abnormal_immune_cell1.20737311
67MP0002697_abnormal_eye_size1.20274373
68MP0002452_abnormal_antigen_presenting1.19103726
69MP0003315_abnormal_perineum_morphology1.18470084
70MP0001286_abnormal_eye_development1.18451772
71MP0001835_abnormal_antigen_presentation1.18052033
72MP0005023_abnormal_wound_healing1.17992570
73MP0005397_hematopoietic_system_phenotyp1.17585785
74MP0001545_abnormal_hematopoietic_system1.17585785
75MP0004185_abnormal_adipocyte_glucose1.17350837
76MP0005075_abnormal_melanosome_morpholog1.15839707
77MP0003303_peritoneal_inflammation1.15701630
78MP0002234_abnormal_pharynx_morphology1.13311217
79MP0008789_abnormal_olfactory_epithelium1.11883383
80MP0005671_abnormal_response_to1.11845860
81MP0006054_spinal_hemorrhage1.11406997
82MP0010234_abnormal_vibrissa_follicle1.09995273
83MP0002405_respiratory_system_inflammati1.09022570
84MP0003283_abnormal_digestive_organ1.06693839
85MP0005501_abnormal_skin_physiology1.05815285
86MP0005499_abnormal_olfactory_system1.05667892
87MP0005394_taste/olfaction_phenotype1.05667892
88MP0002723_abnormal_immune_serum1.05040804
89MP0010155_abnormal_intestine_physiology1.04690231
90MP0003866_abnormal_defecation1.04663682
91MP0002006_tumorigenesis1.03729091
92MP0009053_abnormal_anal_canal1.02468141
93MP0001873_stomach_inflammation1.01210386
94MP0003566_abnormal_cell_adhesion0.99641789
95MP0000631_abnormal_neuroendocrine_gland0.98953821
96MP0000477_abnormal_intestine_morphology0.98951631
97MP0003300_gastrointestinal_ulcer0.94964772
98MP0005000_abnormal_immune_tolerance0.92975431
99MP0000465_gastrointestinal_hemorrhage0.91969246
100MP0003436_decreased_susceptibility_to0.91862885
101MP0002132_abnormal_respiratory_system0.91108029
102MP0002932_abnormal_joint_morphology0.90486979
103MP0000372_irregular_coat_pigmentation0.89794683
104MP0001790_abnormal_immune_system0.88876244
105MP0005387_immune_system_phenotype0.88876244
106MP0001293_anophthalmia0.88846030
107MP0000733_abnormal_muscle_development0.88729670
108MP0002095_abnormal_skin_pigmentation0.88297729
109MP0000762_abnormal_tongue_morphology0.88251089
110MP0003942_abnormal_urinary_system0.86878844
111MP0003119_abnormal_digestive_system0.86730050
112MP0000428_abnormal_craniofacial_morphol0.86030357
113MP0001849_ear_inflammation0.84606645
114MP0002111_abnormal_tail_morphology0.82456473
115MP0008961_abnormal_basal_metabolism0.81627166
116MP0003937_abnormal_limbs/digits/tail_de0.79884713
117MP0005025_abnormal_response_to0.79703206
118MP0002116_abnormal_craniofacial_bone0.78413527
119MP0003448_altered_tumor_morphology0.78393399
120MP0004947_skin_inflammation0.78341965
121MP0009672_abnormal_birth_weight0.77110131
122MP0009250_abnormal_appendicular_skeleto0.76043232
123MP0002653_abnormal_ependyma_morphology0.75244688
124MP0005174_abnormal_tail_pigmentation0.75074629
125MP0003941_abnormal_skin_development0.73438166
126MP0003959_abnormal_lean_body0.72782899
127MP0001145_abnormal_male_reproductive0.72093330
128MP0000358_abnormal_cell_content/0.72082128
129MP0005381_digestive/alimentary_phenotyp0.70557976
130MP0003890_abnormal_embryonic-extraembry0.70376568
131MP0000678_abnormal_parathyroid_gland0.68749052
132MP0003861_abnormal_nervous_system0.68646415
133MP0004133_heterotaxia0.68556010
134MP0001663_abnormal_digestive_system0.68079102
135MP0002092_abnormal_eye_morphology0.67079535
136MP0001915_intracranial_hemorrhage0.65919680
137MP0001216_abnormal_epidermal_layer0.65791368
138MP0001986_abnormal_taste_sensitivity0.64200013
139MP0002233_abnormal_nose_morphology0.64013809
140MP0009785_altered_susceptibility_to0.62844221
141MP0000026_abnormal_inner_ear0.62619521
142MP0002210_abnormal_sex_determination0.62442421
143MP0009931_abnormal_skin_appearance0.62413687
144MP0002796_impaired_skin_barrier0.61982999
145MP0003453_abnormal_keratinocyte_physiol0.61871506
146MP0006035_abnormal_mitochondrial_morpho0.61511486
147MP0008770_decreased_survivor_rate0.61490225

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.42901720
2Abnormality of cells of the erythroid lineage (HP:0012130)7.27101082
3Abnormal number of erythroid precursors (HP:0012131)6.58946808
4Macrocytic anemia (HP:0001972)5.29794843
5Pallor (HP:0000980)4.90672611
6Partial duplication of thumb phalanx (HP:0009944)3.86503458
7Thrombocytosis (HP:0001894)3.79428882
8Partial duplication of the phalanx of hand (HP:0009999)3.66103964
9Colon cancer (HP:0003003)3.55524946
10Abnormality of the parietal bone (HP:0002696)3.38209059
11Septo-optic dysplasia (HP:0100842)3.26885949
12Selective tooth agenesis (HP:0001592)2.87549319
13Increased hepatocellular lipid droplets (HP:0006565)2.80428502
14Basal cell carcinoma (HP:0002671)2.79831452
15Duplication of thumb phalanx (HP:0009942)2.79169241
16Abnormal hemoglobin (HP:0011902)2.78631648
17Abnormality of reticulocytes (HP:0004312)2.75935247
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74593592
19Multiple enchondromatosis (HP:0005701)2.69247324
20IgM deficiency (HP:0002850)2.67565918
2111 pairs of ribs (HP:0000878)2.65872247
22Trismus (HP:0000211)2.63979310
23Breast hypoplasia (HP:0003187)2.57463363
24Absent thumb (HP:0009777)2.54837337
25Respiratory difficulties (HP:0002880)2.54174405
26Oral leukoplakia (HP:0002745)2.51160621
27Broad distal phalanx of finger (HP:0009836)2.49051008
28Rib fusion (HP:0000902)2.48212013
29Lipid accumulation in hepatocytes (HP:0006561)2.47967067
30Aplastic anemia (HP:0001915)2.45416278
31T lymphocytopenia (HP:0005403)2.42215752
32Ependymoma (HP:0002888)2.38994295
33Recurrent bronchitis (HP:0002837)2.35445765
34Maternal diabetes (HP:0009800)2.32205207
35Depressed nasal ridge (HP:0000457)2.30985753
36Carpal bone hypoplasia (HP:0001498)2.29585619
37Patellar aplasia (HP:0006443)2.28561523
38Abnormality of T cells (HP:0002843)2.28381555
39Missing ribs (HP:0000921)2.25649045
40Neoplasm of the pancreas (HP:0002894)2.24426366
41Medulloblastoma (HP:0002885)2.24009388
42Aplasia/Hypoplasia of the patella (HP:0006498)2.23353625
43Birth length less than 3rd percentile (HP:0003561)2.22686934
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21792668
45Abnormality of T cell number (HP:0011839)2.21265488
46Nasolacrimal duct obstruction (HP:0000579)2.20272418
47Thick lower lip vermilion (HP:0000179)2.17971406
48Increased intramyocellular lipid droplets (HP:0012240)2.17883692
49Hyperacusis (HP:0010780)2.13921605
50Chronic otitis media (HP:0000389)2.13572946
51Asplenia (HP:0001746)2.12821207
52Panhypogammaglobulinemia (HP:0003139)2.12206824
53Abnormality of DNA repair (HP:0003254)2.10981838
54Colitis (HP:0002583)2.10901840
55Abnormal number of incisors (HP:0011064)2.08735773
56Microretrognathia (HP:0000308)2.03486471
57Papilloma (HP:0012740)2.03352271
58Verrucae (HP:0200043)2.03352271
59Rough bone trabeculation (HP:0100670)2.02957367
60Nasal polyposis (HP:0100582)2.02730734
61Microvesicular hepatic steatosis (HP:0001414)2.01403159
62Mitochondrial inheritance (HP:0001427)2.01098216
63Atresia of the external auditory canal (HP:0000413)2.00040793
64Aplasia/Hypoplasia of the spleen (HP:0010451)1.99972199
65Degeneration of anterior horn cells (HP:0002398)1.99010851
66Abnormality of the anterior horn cell (HP:0006802)1.99010851
67Recurrent viral infections (HP:0004429)1.99004113
68Acute necrotizing encephalopathy (HP:0006965)1.97962005
69Deep palmar crease (HP:0006191)1.97887917
70Concave nail (HP:0001598)1.96018060
71Lymphoma (HP:0002665)1.94050069
72Abnormal mitochondria in muscle tissue (HP:0008316)1.93691241
73Increased muscle lipid content (HP:0009058)1.93656948
74High anterior hairline (HP:0009890)1.93107840
75Myelodysplasia (HP:0002863)1.92779609
76Rhabdomyosarcoma (HP:0002859)1.92172367
77Absent septum pellucidum (HP:0001331)1.90881107
78Proximal placement of thumb (HP:0009623)1.90582641
79Abnormality of T cell physiology (HP:0011840)1.90367374
80Poikiloderma (HP:0001029)1.89835711
81Overlapping toe (HP:0001845)1.89510174
82Migraine (HP:0002076)1.89281613
83Turricephaly (HP:0000262)1.87642804
84Triphalangeal thumb (HP:0001199)1.86820419
85Abnormality of the fingertips (HP:0001211)1.86413391
86Renal Fanconi syndrome (HP:0001994)1.85826498
87Sparse lateral eyebrow (HP:0005338)1.85717675
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.85565251
89Increased density of long bones (HP:0006392)1.82903136
90Abnormality of the lacrimal duct (HP:0011481)1.82872002
91Bicuspid aortic valve (HP:0001647)1.80788887
92Acute lymphatic leukemia (HP:0006721)1.80772786
93Deviation of the thumb (HP:0009603)1.80336580
94Squamous cell carcinoma (HP:0002860)1.79526384
95Abnormality of cochlea (HP:0000375)1.78411656
96Amaurosis fugax (HP:0100576)1.78318816
97Bilateral microphthalmos (HP:0007633)1.78208562
98Pancytopenia (HP:0001876)1.77384025
99Rectal prolapse (HP:0002035)1.77198379
100Acute encephalopathy (HP:0006846)1.76988107
101Thoracic kyphosis (HP:0002942)1.76886824
102Abnormality of cells of the lymphoid lineage (HP:0012140)1.76159196
103Premature ovarian failure (HP:0008209)1.76062830
104Seborrheic dermatitis (HP:0001051)1.76038343
105Horseshoe kidney (HP:0000085)1.75323853
106Glossoptosis (HP:0000162)1.74710543
107Supernumerary ribs (HP:0005815)1.74690779
108Abnormality of the nasal mucosa (HP:0000433)1.74292861
109Cleft eyelid (HP:0000625)1.73675387
110Cellulitis (HP:0100658)1.73610078
111Gastrointestinal inflammation (HP:0004386)1.73511552
112Woolly hair (HP:0002224)1.73381194
113Hypoplasia of the radius (HP:0002984)1.72134192
114Angiofibromas (HP:0010615)1.72086212
115Adenoma sebaceum (HP:0009720)1.72086212
116Cellular immunodeficiency (HP:0005374)1.71608284
117Premature graying of hair (HP:0002216)1.71474448
118Progressive muscle weakness (HP:0003323)1.70776127
119Elevated erythrocyte sedimentation rate (HP:0003565)1.70354497
120Biliary tract neoplasm (HP:0100574)1.70099509
121Agammaglobulinemia (HP:0004432)1.69868247
122Combined immunodeficiency (HP:0005387)1.69866639
123Abnormality of the septum pellucidum (HP:0007375)1.69352204
124Tracheoesophageal fistula (HP:0002575)1.69099072
125Esophageal atresia (HP:0002032)1.68738392
126Morphological abnormality of the inner ear (HP:0011390)1.67428829
127Aplasia/Hypoplasia of the thymus (HP:0010515)1.65643043
128Abnormality of B cell number (HP:0010975)1.65551941
129B lymphocytopenia (HP:0010976)1.65551941
130Supernumerary bones of the axial skeleton (HP:0009144)1.64932682
131Pustule (HP:0200039)1.64809837
132Protrusio acetabuli (HP:0003179)1.63957625
133Lymphopenia (HP:0001888)1.63866441
134Annular pancreas (HP:0001734)1.63277355
135Stenosis of the external auditory canal (HP:0000402)1.63104518
136Skin tags (HP:0010609)1.62812130
137Meckel diverticulum (HP:0002245)1.61760614
138Preauricular skin tag (HP:0000384)1.61686257
139Abnormality of the nasolacrimal system (HP:0000614)1.61601081
140Inflammation of the large intestine (HP:0002037)1.56902216
141Neoplasm of striated muscle (HP:0009728)1.55772812
142Abnormality of the calcaneus (HP:0008364)1.55692783
143Abnormality of small intestinal villus morphology (HP:0011472)1.55603156
144Villous atrophy (HP:0011473)1.55603156
145Increased nuchal translucency (HP:0010880)1.55182080
146Chromosomal breakage induced by crosslinking agents (HP:0003221)1.54748490
147Duplicated collecting system (HP:0000081)1.53006593
148Short nose (HP:0003196)1.52045639
149Trigonocephaly (HP:0000243)1.50969650
150Increased CSF lactate (HP:0002490)1.48589281
151Hepatocellular necrosis (HP:0001404)1.47141115
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.46846191
153Truncus arteriosus (HP:0001660)1.45856427
154Forearm undergrowth (HP:0009821)1.45025224
155Chromsome breakage (HP:0040012)1.44623299
156Anophthalmia (HP:0000528)1.42037126
157Premature skin wrinkling (HP:0100678)1.40901245
158Testicular atrophy (HP:0000029)1.40644330
159Short thumb (HP:0009778)1.40552965
160Optic nerve coloboma (HP:0000588)1.40508379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.66357185
2VRK23.74628289
3NME23.65401941
4EEF2K3.56699957
5SMG13.08282094
6MAP3K103.05571346
7BUB12.89958010
8MAP4K12.65646289
9WEE12.53298235
10CDC72.43579513
11PKN22.36551625
12RPS6KB22.36405670
13LRRK22.35617813
14NEK22.29278379
15TESK22.22391841
16PASK1.88504420
17PRPF4B1.88003323
18TRIB31.86659712
19RPS6KA41.84041853
20TAF11.83273891
21SRPK11.81926181
22STK101.81454049
23EIF2AK11.66022581
24TGFBR11.43550889
25DYRK31.40837194
26MAP3K81.40301504
27GRK61.39738302
28EPHB21.38344247
29AURKB1.35909358
30ZAK1.33349796
31SCYL21.33269534
32ZAP701.32345838
33CDK41.32174488
34FLT31.28054246
35CDK71.24874209
36TSSK61.22410367
37TYRO31.21463899
38PAK41.20102488
39ILK1.16281213
40PLK11.12313167
41TTK1.11980727
42SIK11.11865688
43MAPK151.10520030
44CDK191.09153853
45ATR1.07420389
46PIM11.06166925
47CDK121.03703061
48BLK1.03499812
49BTK1.02537754
50EPHA21.02008844
51STK161.01337638
52IRAK40.99951285
53MAPKAPK30.98133994
54VRK10.95958330
55KDR0.95119440
56MKNK10.94519073
57ACVR1B0.92554178
58PIM20.91102155
59TYK20.90654440
60ALK0.90345718
61NEK10.89266942
62MST40.89226508
63IRAK20.88469646
64JAK30.87041927
65BRAF0.86941977
66STK40.86608503
67EIF2AK30.86158943
68TESK10.83520705
69MKNK20.82924219
70DYRK1B0.80452885
71AURKA0.80448884
72CHEK10.78055070
73BRSK20.77803530
74FGFR20.77249759
75CDK80.77221052
76ICK0.74086072
77MAP2K20.73409107
78RPS6KA50.73253896
79HIPK20.72837064
80MAP2K30.72653758
81ITK0.67712340
82DYRK20.65252499
83PTK60.64669418
84CSNK2A20.64312245
85PRKCI0.62356926
86CHEK20.60208314
87PAK20.60198575
88CDK20.59874588
89CDK60.59831789
90MAP3K110.59240106
91PAK10.58834271
92NLK0.58348134
93TEC0.56756519
94IKBKB0.54635940
95FGFR40.54071501
96CLK10.53704558
97CSF1R0.53545901
98LCK0.53424493
99BCKDK0.53400523
100MARK20.52464063
101ARAF0.51961603
102FES0.50679062
103ATM0.48930573
104SYK0.47517304
105MAP3K130.43624754
106CSNK2A10.43492955
107MTOR0.41758476
108BMX0.41676763
109CAMKK10.41573778
110TXK0.41265843
111TTN0.40599949
112IKBKE0.40551390
113STK240.40299109
114RIPK10.40123830
115ERN10.39404906
116NME10.38722740
117RPS6KA10.36763558
118PRKCQ0.36631337
119TBK10.36551777
120PLK40.36172506
121LYN0.35550173
122NEK90.34693772
123BRSK10.34269650
124RPS6KC10.34145826
125RPS6KL10.34145826
126BRD40.33651540
127WNK40.33032092
128KIT0.32315510
129RPS6KA60.32238048
130AKT10.31822341
131MELK0.31085317
132MARK30.30992778
133PRKD30.30411413
134NUAK10.28847859
135PRKCD0.27268640

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.67673035
2DNA replication_Homo sapiens_hsa030304.14183342
3Mismatch repair_Homo sapiens_hsa034303.43662418
4Spliceosome_Homo sapiens_hsa030403.26049434
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72189328
6Oxidative phosphorylation_Homo sapiens_hsa001902.64898432
7RNA transport_Homo sapiens_hsa030132.60233650
8RNA polymerase_Homo sapiens_hsa030202.53427665
9Base excision repair_Homo sapiens_hsa034102.49105820
10Nucleotide excision repair_Homo sapiens_hsa034202.38473484
11Homologous recombination_Homo sapiens_hsa034402.38290753
12Proteasome_Homo sapiens_hsa030502.35095798
13One carbon pool by folate_Homo sapiens_hsa006702.15887175
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03338575
15Cell cycle_Homo sapiens_hsa041102.00591035
16Pyrimidine metabolism_Homo sapiens_hsa002401.93991395
17Primary immunodeficiency_Homo sapiens_hsa053401.88954443
18Systemic lupus erythematosus_Homo sapiens_hsa053221.57907189
19Alzheimers disease_Homo sapiens_hsa050101.53429004
20Fanconi anemia pathway_Homo sapiens_hsa034601.53123158
21mRNA surveillance pathway_Homo sapiens_hsa030151.51666246
22Antigen processing and presentation_Homo sapiens_hsa046121.51309942
23Non-homologous end-joining_Homo sapiens_hsa034501.50675921
24p53 signaling pathway_Homo sapiens_hsa041151.44123608
25RNA degradation_Homo sapiens_hsa030181.37518368
26Sulfur relay system_Homo sapiens_hsa041221.31947374
27Cardiac muscle contraction_Homo sapiens_hsa042601.22011739
28Epstein-Barr virus infection_Homo sapiens_hsa051691.17091853
29Basal transcription factors_Homo sapiens_hsa030221.13796583
30Herpes simplex infection_Homo sapiens_hsa051681.12355811
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10292831
32Viral carcinogenesis_Homo sapiens_hsa052031.09829153
33HTLV-I infection_Homo sapiens_hsa051661.02137928
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.99055323
35Small cell lung cancer_Homo sapiens_hsa052220.91946741
36Thyroid cancer_Homo sapiens_hsa052160.88221260
37Chronic myeloid leukemia_Homo sapiens_hsa052200.87818360
38Measles_Homo sapiens_hsa051620.79932630
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.79741078
40B cell receptor signaling pathway_Homo sapiens_hsa046620.79549555
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79020977
42T cell receptor signaling pathway_Homo sapiens_hsa046600.78858729
43Purine metabolism_Homo sapiens_hsa002300.78439301
44Acute myeloid leukemia_Homo sapiens_hsa052210.78204349
45Pentose phosphate pathway_Homo sapiens_hsa000300.76780301
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75118255
47Apoptosis_Homo sapiens_hsa042100.72326155
48Notch signaling pathway_Homo sapiens_hsa043300.71375713
49MicroRNAs in cancer_Homo sapiens_hsa052060.70940727
50Hematopoietic cell lineage_Homo sapiens_hsa046400.70523326
51Bladder cancer_Homo sapiens_hsa052190.67966752
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67106355
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65274126
54Basal cell carcinoma_Homo sapiens_hsa052170.61795881
55Alcoholism_Homo sapiens_hsa050340.61519524
56Protein export_Homo sapiens_hsa030600.59634215
57Wnt signaling pathway_Homo sapiens_hsa043100.58287873
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.58245781
59Colorectal cancer_Homo sapiens_hsa052100.57235191
60Hepatitis B_Homo sapiens_hsa051610.56841982
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55370668
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55081843
63Shigellosis_Homo sapiens_hsa051310.54745752
64Selenocompound metabolism_Homo sapiens_hsa004500.52162099
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51921555
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.51022135
67Legionellosis_Homo sapiens_hsa051340.51014981
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.47661364
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47511731
70Folate biosynthesis_Homo sapiens_hsa007900.47411056
71Leishmaniasis_Homo sapiens_hsa051400.46683604
72Non-small cell lung cancer_Homo sapiens_hsa052230.46665382
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45722535
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45590659
75Oocyte meiosis_Homo sapiens_hsa041140.44481218
76Autoimmune thyroid disease_Homo sapiens_hsa053200.44189934
77Pathways in cancer_Homo sapiens_hsa052000.43547460
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43126880
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42268636
80Endometrial cancer_Homo sapiens_hsa052130.42199460
81HIF-1 signaling pathway_Homo sapiens_hsa040660.41525846
82Viral myocarditis_Homo sapiens_hsa054160.41324710
83Hippo signaling pathway_Homo sapiens_hsa043900.41246153
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41114805
85ErbB signaling pathway_Homo sapiens_hsa040120.40744072
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40569672
87Toxoplasmosis_Homo sapiens_hsa051450.40268683
88Biosynthesis of amino acids_Homo sapiens_hsa012300.39767184
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39506444
90Huntingtons disease_Homo sapiens_hsa050160.39491188
91Graft-versus-host disease_Homo sapiens_hsa053320.39404306
92Allograft rejection_Homo sapiens_hsa053300.39128558
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37680471
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36884294
95TGF-beta signaling pathway_Homo sapiens_hsa043500.36761212
96Influenza A_Homo sapiens_hsa051640.36165926
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.35964702
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.35398379
99Vitamin digestion and absorption_Homo sapiens_hsa049770.34862149
100mTOR signaling pathway_Homo sapiens_hsa041500.34198771
101Pancreatic cancer_Homo sapiens_hsa052120.34000354
102Parkinsons disease_Homo sapiens_hsa050120.33485759
103Proteoglycans in cancer_Homo sapiens_hsa052050.32981365
104N-Glycan biosynthesis_Homo sapiens_hsa005100.31393616
105Prostate cancer_Homo sapiens_hsa052150.31130541
106Osteoclast differentiation_Homo sapiens_hsa043800.30813560
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27536008
108Hedgehog signaling pathway_Homo sapiens_hsa043400.27209090
109Melanogenesis_Homo sapiens_hsa049160.25926944
110VEGF signaling pathway_Homo sapiens_hsa043700.25825424
111Carbon metabolism_Homo sapiens_hsa012000.25440726
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24722196
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24493019
114Renal cell carcinoma_Homo sapiens_hsa052110.24426448
115Glutathione metabolism_Homo sapiens_hsa004800.23980305
116Platelet activation_Homo sapiens_hsa046110.23618084
117Metabolic pathways_Homo sapiens_hsa011000.23333674
118Asthma_Homo sapiens_hsa053100.22929213
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22714531
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.21400497
121Choline metabolism in cancer_Homo sapiens_hsa052310.21237746
122Tyrosine metabolism_Homo sapiens_hsa003500.19073199
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18093128
124Lysine degradation_Homo sapiens_hsa003100.16979816

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