ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.27386488
2	behavioral response to nicotine (GO:0035095)	6.20628518
3	ribosomal small subunit assembly (GO:0000028)	6.06857047
4	translational termination (GO:0006415)	6.03394458
5	ribosomal small subunit biogenesis (GO:0042274)	5.84655455
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.96425239
7	protein targeting to ER (GO:0045047)	4.94302629
8	translational elongation (GO:0006414)	4.93463886
9	cotranslational protein targeting to membrane (GO:0006613)	4.93025276
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.85116651
11	maturation of SSU-rRNA (GO:0030490)	4.84217736
12	pattern specification involved in kidney development (GO:0061004)	4.78330628
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.73756618
14	protein localization to endoplasmic reticulum (GO:0070972)	4.70021699
15	cellular protein complex disassembly (GO:0043624)	4.51761570
16	viral life cycle (GO:0019058)	4.39979076
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.38445139
18	tongue development (GO:0043586)	4.18362074
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.13335688
20	auditory receptor cell differentiation (GO:0042491)	4.06515049
21	synaptic transmission, cholinergic (GO:0007271)	4.04166501
22	substrate-independent telencephalic tangential migration (GO:0021826)	3.92695515
23	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.92695515
24	protein complex disassembly (GO:0043241)	3.86083406
25	ATP synthesis coupled proton transport (GO:0015986)	3.80812012
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.80812012
27	negative regulation of granulocyte differentiation (GO:0030853)	3.79807764
28	neuron fate determination (GO:0048664)	3.77355643
29	pyrimidine nucleobase catabolic process (GO:0006208)	3.72854497
30	protein polyglutamylation (GO:0018095)	3.72138621
31	nonmotile primary cilium assembly (GO:0035058)	3.72091248
32	translational initiation (GO:0006413)	3.71501393
33	head development (GO:0060322)	3.70510191
34	macromolecular complex disassembly (GO:0032984)	3.69459765
35	epithelial cilium movement (GO:0003351)	3.59772028
36	intraciliary transport (GO:0042073)	3.57329164
37	protein targeting to membrane (GO:0006612)	3.51375587
38	segment specification (GO:0007379)	3.35888939
39	somite development (GO:0061053)	3.33306162
40	cell proliferation in forebrain (GO:0021846)	3.31192463
41	axonal fasciculation (GO:0007413)	3.27875594
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25758675
43	NADH dehydrogenase complex assembly (GO:0010257)	3.25758675
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25758675
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.25151168
46	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23418111
47	chaperone-mediated protein transport (GO:0072321)	3.15739783
48	protein complex biogenesis (GO:0070271)	3.13442069
49	endoderm formation (GO:0001706)	3.10880591
50	motile cilium assembly (GO:0044458)	3.09373163
51	postsynaptic membrane organization (GO:0001941)	3.09056710
52	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.05565630
53	fucose catabolic process (GO:0019317)	3.03041647
54	L-fucose metabolic process (GO:0042354)	3.03041647
55	L-fucose catabolic process (GO:0042355)	3.03041647
56	nucleobase catabolic process (GO:0046113)	2.98515734
57	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.97978282
58	translation (GO:0006412)	2.97662066
59	DNA deamination (GO:0045006)	2.97294096
60	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.92496382
61	cilium movement (GO:0003341)	2.92468508
62	GTP biosynthetic process (GO:0006183)	2.92354077
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.92140750
64	axoneme assembly (GO:0035082)	2.91256267
65	nephron tubule morphogenesis (GO:0072078)	2.89782813
66	nephron epithelium morphogenesis (GO:0072088)	2.89782813
67	mRNA catabolic process (GO:0006402)	2.87830438
68	transmission of nerve impulse (GO:0019226)	2.86217288
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85349784
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85349784
71	regulation of cilium movement (GO:0003352)	2.84795412
72	cerebral cortex radially oriented cell migration (GO:0021799)	2.83871026
73	central nervous system myelination (GO:0022010)	2.82742881
74	axon ensheathment in central nervous system (GO:0032291)	2.82742881
75	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.82131431
76	rRNA catabolic process (GO:0016075)	2.74608286
77	resolution of meiotic recombination intermediates (GO:0000712)	2.69236639
78	telencephalon development (GO:0021537)	2.64880076
79	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.64411703
80	genetic imprinting (GO:0071514)	2.63953629
81	cellular component biogenesis (GO:0044085)	2.63796826
82	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.62758912
83	ncRNA 3-end processing (GO:0043628)	2.62305997
84	olfactory bulb development (GO:0021772)	2.61134182
85	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.60862280
86	indolalkylamine metabolic process (GO:0006586)	2.60049038
87	protein neddylation (GO:0045116)	2.59574981
88	RNA catabolic process (GO:0006401)	2.58594034
89	body morphogenesis (GO:0010171)	2.57245105
90	negative regulation of macrophage differentiation (GO:0045650)	2.56836263
91	positive regulation of mitochondrial fission (GO:0090141)	2.55900370
92	ribonucleoprotein complex biogenesis (GO:0022613)	2.55775446
93	regulation of granulocyte differentiation (GO:0030852)	2.55266611
94	photoreceptor cell maintenance (GO:0045494)	2.55239534
95	negative regulation of astrocyte differentiation (GO:0048712)	2.54350528
96	protein localization to cilium (GO:0061512)	2.53992105
97	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.53806604
98	negative regulation of telomere maintenance (GO:0032205)	2.52120431
99	regulation of cellular respiration (GO:0043457)	2.51518245
100	embryonic body morphogenesis (GO:0010172)	2.51494956

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.74944355
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.52493990
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.72020574
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30437347
5	IRF1_19129219_ChIP-ChIP_H3396_Human	2.21578882
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.12792252
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.11010697
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.10372153
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.05880264
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.05171813
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.04220898
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.02339914
13	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.99098224
14	ZNF274_21170338_ChIP-Seq_K562_Hela	1.94192006
15	REST_21632747_ChIP-Seq_MESCs_Mouse	1.91764859
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.90239031
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89526248
18	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.88603198
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.77390649
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.73363388
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.71080800
22	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.64053274
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63251281
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62940102
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.62554685
26	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.59839993
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.58242987
28	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.56933075
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.56809514
30	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.53492770
31	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52000253
32	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52000253
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51021151
34	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.49643875
35	VDR_22108803_ChIP-Seq_LS180_Human	1.48552476
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47453717
37	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.45791686
38	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.45453135
39	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.43246842
40	ERA_21632823_ChIP-Seq_H3396_Human	1.36478343
41	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.33483181
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32372541
43	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.31710321
44	IGF1R_20145208_ChIP-Seq_DFB_Human	1.30200787
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28020673
46	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.25869896
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24035886
48	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23457862
49	CTCF_27219007_Chip-Seq_Bcells_Human	1.20508004
50	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.20199679
51	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.19673555
52	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.18652413
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17707880
54	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.17517439
55	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.17381758
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.17267528
57	NCOR_22424771_ChIP-Seq_293T_Human	1.16220810
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15388959
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.14715169
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14260657
61	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.13175648
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11795572
63	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.11788337
64	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.09823143
65	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09377370
66	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.06641612
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05927898
68	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05032331
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04061680
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03940068
71	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.03046078
72	FUS_26573619_Chip-Seq_HEK293_Human	1.03006512
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01795264
74	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.01219011
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00591897
76	GBX2_23144817_ChIP-Seq_PC3_Human	0.99609979
77	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.98363498
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98127655
79	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.98006558
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.97617917
81	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95010985
82	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.93467324
83	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.93421053
84	SA1_27219007_Chip-Seq_Bcells_Human	0.93317816
85	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92982075
86	OCT4_19829295_ChIP-Seq_ESCs_Human	0.92717161
87	GABP_19822575_ChIP-Seq_HepG2_Human	0.91945159
88	MYC_19829295_ChIP-Seq_ESCs_Human	0.90902309
89	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.90017790
90	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.88371632
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88371632
92	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.88140582
93	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87590211
94	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.87233661
95	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.86480214
96	EWS_26573619_Chip-Seq_HEK293_Human	0.86396736
97	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.86335829
98	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84529470
99	XRN2_22483619_ChIP-Seq_HELA_Human	0.84472561
100	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.84234839

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.71210580
2	MP0006292_abnormal_olfactory_placode	4.64076233
3	MP0009379_abnormal_foot_pigmentation	4.41893156
4	MP0003122_maternal_imprinting	3.80799611
5	MP0008877_abnormal_DNA_methylation	3.53743242
6	MP0003121_genomic_imprinting	3.13549668
7	MP0002653_abnormal_ependyma_morphology	2.66910468
8	MP0008789_abnormal_olfactory_epithelium	2.50165353
9	MP0005499_abnormal_olfactory_system	2.28723063
10	MP0005394_taste/olfaction_phenotype	2.28723063
11	MP0004133_heterotaxia	2.27257085
12	MP0004142_abnormal_muscle_tone	2.27215940
13	MP0003879_abnormal_hair_cell	2.05577264
14	MP0001348_abnormal_lacrimal_gland	2.01404602
15	MP0003123_paternal_imprinting	1.98640252
16	MP0004742_abnormal_vestibular_system	1.92298884
17	MP0004885_abnormal_endolymph	1.92226842
18	MP0000778_abnormal_nervous_system	1.91589481
19	MP0003878_abnormal_ear_physiology	1.83145039
20	MP0005377_hearing/vestibular/ear_phenot	1.83145039
21	MP0001293_anophthalmia	1.79398275
22	MP0001968_abnormal_touch/_nociception	1.73923886
23	MP0006276_abnormal_autonomic_nervous	1.71841108
24	MP0001440_abnormal_grooming_behavior	1.68773768
25	MP0003136_yellow_coat_color	1.64680550
26	MP0002736_abnormal_nociception_after	1.63568533
27	MP0005551_abnormal_eye_electrophysiolog	1.61958475
28	MP0000049_abnormal_middle_ear	1.59377547
29	MP0008875_abnormal_xenobiotic_pharmacok	1.48751301
30	MP0002272_abnormal_nervous_system	1.46690314
31	MP0002184_abnormal_innervation	1.46644137
32	MP0001485_abnormal_pinna_reflex	1.46531731
33	MP0003646_muscle_fatigue	1.46463469
34	MP0002102_abnormal_ear_morphology	1.41849464
35	MP0006072_abnormal_retinal_apoptosis	1.39855961
36	MP0003942_abnormal_urinary_system	1.38565089
37	MP0002234_abnormal_pharynx_morphology	1.38553627
38	MP0002557_abnormal_social/conspecific_i	1.36703772
39	MP0002638_abnormal_pupillary_reflex	1.34230712
40	MP0004145_abnormal_muscle_electrophysio	1.32928795
41	MP0002163_abnormal_gland_morphology	1.31567069
42	MP0002733_abnormal_thermal_nociception	1.29799997
43	MP0003011_delayed_dark_adaptation	1.29525878
44	MP0005195_abnormal_posterior_eye	1.26751268
45	MP0008872_abnormal_physiological_respon	1.25486125
46	MP0009745_abnormal_behavioral_response	1.24043016
47	MP0005423_abnormal_somatic_nervous	1.21400586
48	MP0000026_abnormal_inner_ear	1.19920899
49	MP0010030_abnormal_orbit_morphology	1.19372634
50	MP0002938_white_spotting	1.19355637
51	MP0003890_abnormal_embryonic-extraembry	1.18160045
52	MP0002752_abnormal_somatic_nervous	1.16948768
53	MP0003635_abnormal_synaptic_transmissio	1.10726371
54	MP0001970_abnormal_pain_threshold	1.10537424
55	MP0001984_abnormal_olfaction	1.09524971
56	MP0003880_abnormal_central_pattern	1.09288325
57	MP0002063_abnormal_learning/memory/cond	1.08719405
58	MP0001502_abnormal_circadian_rhythm	1.07261326
59	MP0001963_abnormal_hearing_physiology	1.06876251
60	MP0004859_abnormal_synaptic_plasticity	1.05175013
61	MP0005253_abnormal_eye_physiology	1.03395849
62	MP0002233_abnormal_nose_morphology	1.02704886
63	MP0000955_abnormal_spinal_cord	1.01004645
64	MP0001529_abnormal_vocalization	1.00145977
65	MP0001986_abnormal_taste_sensitivity	0.99587962
66	MP0003938_abnormal_ear_development	0.99461567
67	MP0000631_abnormal_neuroendocrine_gland	0.98652679
68	MP0002572_abnormal_emotion/affect_behav	0.97790366
69	MP0001486_abnormal_startle_reflex	0.97640072
70	MP0002837_dystrophic_cardiac_calcinosis	0.96954734
71	MP0008058_abnormal_DNA_repair	0.96942998
72	MP0001324_abnormal_eye_pigmentation	0.96616101
73	MP0002735_abnormal_chemical_nociception	0.95995465
74	MP0004147_increased_porphyrin_level	0.95240842
75	MP0000427_abnormal_hair_cycle	0.95100662
76	MP0002928_abnormal_bile_duct	0.93379600
77	MP0009046_muscle_twitch	0.93371410
78	MP0002734_abnormal_mechanical_nocicepti	0.89694393
79	MP0003567_abnormal_fetal_cardiomyocyte	0.89605052
80	MP0001919_abnormal_reproductive_system	0.88587435
81	MP0005084_abnormal_gallbladder_morpholo	0.88401971
82	MP0002882_abnormal_neuron_morphology	0.87762711
83	MP0002067_abnormal_sensory_capabilities	0.85917160
84	MP0001905_abnormal_dopamine_level	0.85889786
85	MP0008775_abnormal_heart_ventricle	0.85716478
86	MP0000566_synostosis	0.85185467
87	MP0005389_reproductive_system_phenotype	0.84709620
88	MP0005391_vision/eye_phenotype	0.81782762
89	MP0002064_seizures	0.79493390
90	MP0002160_abnormal_reproductive_system	0.79484630
91	MP0002152_abnormal_brain_morphology	0.78941714
92	MP0003937_abnormal_limbs/digits/tail_de	0.78285686
93	MP0002229_neurodegeneration	0.78188337
94	MP0001286_abnormal_eye_development	0.75016124
95	MP0002210_abnormal_sex_determination	0.74643152
96	MP0002876_abnormal_thyroid_physiology	0.73400282
97	MP0003755_abnormal_palate_morphology	0.71433410
98	MP0005174_abnormal_tail_pigmentation	0.70321119
99	MP0002138_abnormal_hepatobiliary_system	0.69634440
100	MP0000534_abnormal_ureter_morphology	0.68371619

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.72709242
2	Molar tooth sign on MRI (HP:0002419)	4.34991587
3	Abnormality of midbrain morphology (HP:0002418)	4.34991587
4	Pancreatic fibrosis (HP:0100732)	3.90586013
5	Asplenia (HP:0001746)	3.66716108
6	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.63452885
7	Nephronophthisis (HP:0000090)	3.59246431
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.52403322
9	Pancreatic cysts (HP:0001737)	3.45650697
10	Supernumerary spleens (HP:0009799)	3.37949470
11	Papilledema (HP:0001085)	3.37113758
12	True hermaphroditism (HP:0010459)	3.09880984
13	Type II lissencephaly (HP:0007260)	3.06569211
14	Abnormality of the labia minora (HP:0012880)	3.02411872
15	Abnormality of the renal medulla (HP:0100957)	2.99032558
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.96406664
17	Acute necrotizing encephalopathy (HP:0006965)	2.90316589
18	Rib fusion (HP:0000902)	2.86164833
19	Medial flaring of the eyebrow (HP:0010747)	2.81666809
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.81102845
21	Macrocytic anemia (HP:0001972)	2.80235727
22	Hyperglycinemia (HP:0002154)	2.73965907
23	Abnormal biliary tract physiology (HP:0012439)	2.67935274
24	Bile duct proliferation (HP:0001408)	2.67935274
25	Cystic liver disease (HP:0006706)	2.62121531
26	Colon cancer (HP:0003003)	2.61354430
27	Acute encephalopathy (HP:0006846)	2.60638419
28	Abnormal number of erythroid precursors (HP:0012131)	2.59913160
29	Polyuria (HP:0000103)	2.52336658
30	Abnormality of the renal cortex (HP:0011035)	2.50785728
31	Gait imbalance (HP:0002141)	2.49989969
32	Abnormal mitochondria in muscle tissue (HP:0008316)	2.47291483
33	Chronic hepatic failure (HP:0100626)	2.46117390
34	Polyphagia (HP:0002591)	2.41255550
35	Anomalous pulmonary venous return (HP:0010772)	2.40901337
36	Adrenal hypoplasia (HP:0000835)	2.40694331
37	Lissencephaly (HP:0001339)	2.39003357
38	Decreased central vision (HP:0007663)	2.38960481
39	Cerebellar dysplasia (HP:0007033)	2.38419503
40	Progressive macrocephaly (HP:0004481)	2.36645768
41	Increased CSF lactate (HP:0002490)	2.36289785
42	Congenital stationary night blindness (HP:0007642)	2.35496431
43	Absent/shortened dynein arms (HP:0200106)	2.33387098
44	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.33387098
45	Mitochondrial inheritance (HP:0001427)	2.32456690
46	Abnormality of DNA repair (HP:0003254)	2.30021899
47	Tubular atrophy (HP:0000092)	2.27342911
48	Optic disc pallor (HP:0000543)	2.26593766
49	Pachygyria (HP:0001302)	2.26562581
50	Abnormal drinking behavior (HP:0030082)	2.26021497
51	Polydipsia (HP:0001959)	2.26021497
52	Pendular nystagmus (HP:0012043)	2.25669586
53	Renal cortical cysts (HP:0000803)	2.25573069
54	Septo-optic dysplasia (HP:0100842)	2.22366207
55	Nephrogenic diabetes insipidus (HP:0009806)	2.22160583
56	Congenital primary aphakia (HP:0007707)	2.21606243
57	Hip dysplasia (HP:0001385)	2.17271091
58	Sclerocornea (HP:0000647)	2.17076306
59	Type 2 muscle fiber atrophy (HP:0003554)	2.10877726
60	Muscle fiber atrophy (HP:0100295)	2.09879253
61	Failure to thrive in infancy (HP:0001531)	2.07829515
62	Congenital hepatic fibrosis (HP:0002612)	2.04613662
63	Myokymia (HP:0002411)	2.03863610
64	Abnormal ciliary motility (HP:0012262)	2.03778769
65	Pallor (HP:0000980)	2.02906937
66	Abnormal eating behavior (HP:0100738)	2.00825302
67	Hyperglycinuria (HP:0003108)	2.00577611
68	Abnormal respiratory epithelium morphology (HP:0012253)	2.00150422
69	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00150422
70	Abnormality of the pulmonary veins (HP:0011718)	1.99053838
71	Annular pancreas (HP:0001734)	1.97984084
72	Abnormal urine output (HP:0012590)	1.97745411
73	Abnormality of magnesium homeostasis (HP:0004921)	1.95558230
74	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.94620543
75	Poor suck (HP:0002033)	1.93658144
76	Hepatocellular necrosis (HP:0001404)	1.91678333
77	Agitation (HP:0000713)	1.91195791
78	Abolished electroretinogram (ERG) (HP:0000550)	1.90520745
79	Anencephaly (HP:0002323)	1.90014462
80	Occipital encephalocele (HP:0002085)	1.89828065
81	Hypoplasia of the radius (HP:0002984)	1.89525220
82	Narrow forehead (HP:0000341)	1.88156395
83	Postaxial foot polydactyly (HP:0001830)	1.87533987
84	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.86153733
85	Hypoplasia of the brainstem (HP:0002365)	1.86153733
86	Hypoplasia of the ulna (HP:0003022)	1.85543266
87	Poor coordination (HP:0002370)	1.84538740
88	Abdominal situs inversus (HP:0003363)	1.84078537
89	Abnormality of abdominal situs (HP:0011620)	1.84078537
90	Oligodactyly (hands) (HP:0001180)	1.83997693
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83394944
92	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.82112336
93	Male pseudohermaphroditism (HP:0000037)	1.81020155
94	Multicystic kidney dysplasia (HP:0000003)	1.78542023
95	Hypoplastic pelvis (HP:0008839)	1.77963901
96	Oligomenorrhea (HP:0000876)	1.77667990
97	Depressed nasal ridge (HP:0000457)	1.76697689
98	Cerebral edema (HP:0002181)	1.76301205
99	Postaxial hand polydactyly (HP:0001162)	1.75871236
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.74898075

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.57560841
2	WNK4	3.83643081
3	TIE1	3.27060904
4	MAP3K9	2.72672428
5	EPHB2	2.52754323
6	NUAK1	2.44083854
7	BCKDK	2.02980362
8	ADRBK2	1.98267890
9	BMPR1B	1.97217968
10	GRK1	1.87345186
11	MARK2	1.80812997
12	EPHA4	1.76944843
13	TLK1	1.75814357
14	SIK2	1.65626179
15	STK39	1.56878054
16	DYRK2	1.56566016
17	DYRK1B	1.52714492
18	MAPK13	1.51692528
19	TNIK	1.48609278
20	NTRK2	1.47158611
21	PIK3CA	1.46204397
22	CAMKK2	1.45617884
23	DMPK	1.42362620
24	CDK19	1.41994114
25	FRK	1.35028592
26	WNK1	1.30913437
27	TXK	1.30115666
28	PAK3	1.23482747
29	PDK2	1.14299247
30	PINK1	1.10959473
31	TAOK3	1.10246665
32	TYRO3	1.08953646
33	RPS6KA2	1.08090833
34	NME1	1.07429447
35	TAF1	1.06231060
36	CAMKK1	1.04932196
37	VRK2	1.04378717
38	OXSR1	1.04257294
39	MAP3K11	1.00066064
40	PRKCG	0.99322424
41	WNK3	0.97740248
42	MARK1	0.96963075
43	PLK4	0.95266363
44	CAMK1	0.94928871
45	RPS6KA6	0.87375123
46	MINK1	0.84979798
47	TGFBR1	0.84525231
48	BRAF	0.82739303
49	CAMK1D	0.82057094
50	PRKCH	0.80198457
51	AURKA	0.79313953
52	RPS6KL1	0.76222885
53	RPS6KC1	0.76222885
54	PRKCZ	0.75619070
55	PIM2	0.74555044
56	MAP4K1	0.72239000
57	SGK223	0.72023646
58	SGK494	0.72023646
59	STK11	0.70508884
60	NEK2	0.70297039
61	PHKG1	0.68212960
62	PHKG2	0.68212960
63	MAP2K2	0.66948476
64	ADRBK1	0.66137933
65	DAPK3	0.65505588
66	INSRR	0.63742289
67	PRKACA	0.63126714
68	VRK1	0.61481290
69	NEK1	0.61470270
70	NTRK3	0.59156065
71	CSNK1E	0.57519909
72	PRKCQ	0.57116486
73	SRPK1	0.56166518
74	SGK1	0.55425751
75	MAP3K7	0.54766886
76	CDC7	0.51458028
77	PLK1	0.50078451
78	PLK2	0.49681377
79	PRKCI	0.49320108
80	CSNK1G2	0.49223496
81	ARAF	0.48780538
82	MAPKAPK5	0.48569141
83	DYRK1A	0.47919606
84	PASK	0.47190370
85	FES	0.46877008
86	AURKB	0.46406365
87	BRSK1	0.46336225
88	MAP3K13	0.45263675
89	CDK14	0.44845982
90	MKNK2	0.44782536
91	CASK	0.44728890
92	LRRK2	0.44307812
93	CAMK2A	0.43037021
94	TEC	0.39913829
95	PRKCA	0.39606764
96	CSNK2A2	0.39460162
97	CAMK1G	0.37555569
98	PRKCE	0.36872828
99	PRKAA1	0.36422885
100	CDK15	0.35707896

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.89063116
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.40360519
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.93438793
4	Parkinsons disease_Homo sapiens_hsa05012	2.71718710
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.65729107
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.57745447
7	Phototransduction_Homo sapiens_hsa04744	2.30898426
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.10158649
9	Homologous recombination_Homo sapiens_hsa03440	2.09893410
10	Huntingtons disease_Homo sapiens_hsa05016	2.05036317
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02017674
12	Alzheimers disease_Homo sapiens_hsa05010	1.99058586
13	RNA polymerase_Homo sapiens_hsa03020	1.98652135
14	Protein export_Homo sapiens_hsa03060	1.94739534
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85584562
16	Nicotine addiction_Homo sapiens_hsa05033	1.83021675
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.80852123
18	Caffeine metabolism_Homo sapiens_hsa00232	1.70231687
19	Sulfur relay system_Homo sapiens_hsa04122	1.69913449
20	Peroxisome_Homo sapiens_hsa04146	1.60696959
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.58008616
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.54911556
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44266990
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.44240528
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43925803
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43754424
27	RNA degradation_Homo sapiens_hsa03018	1.43040390
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.35079155
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.31451787
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26178408
31	Propanoate metabolism_Homo sapiens_hsa00640	1.23937204
32	Mismatch repair_Homo sapiens_hsa03430	1.20913181
33	Olfactory transduction_Homo sapiens_hsa04740	1.20651633
34	Butanoate metabolism_Homo sapiens_hsa00650	1.15626541
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13897898
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.11566859
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11364247
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03779879
39	Insulin secretion_Homo sapiens_hsa04911	1.01886249
40	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.01091417
41	Basal transcription factors_Homo sapiens_hsa03022	1.00294447
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97812730
43	Asthma_Homo sapiens_hsa05310	0.94028570
44	Folate biosynthesis_Homo sapiens_hsa00790	0.92663240
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.91640297
46	Morphine addiction_Homo sapiens_hsa05032	0.89531746
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.84634759
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84504003
49	Axon guidance_Homo sapiens_hsa04360	0.83592943
50	Nitrogen metabolism_Homo sapiens_hsa00910	0.80031741
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.78820566
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78636034
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78134415
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74893338
55	Metabolic pathways_Homo sapiens_hsa01100	0.74654330
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74616549
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.73194133
58	Cocaine addiction_Homo sapiens_hsa05030	0.70620474
59	One carbon pool by folate_Homo sapiens_hsa00670	0.70372344
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69868550
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69238263
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.69074294
63	Base excision repair_Homo sapiens_hsa03410	0.65878478
64	Fatty acid degradation_Homo sapiens_hsa00071	0.65720707
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65553548
66	Retinol metabolism_Homo sapiens_hsa00830	0.61568702
67	Cholinergic synapse_Homo sapiens_hsa04725	0.60071794
68	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.59793917
69	Circadian entrainment_Homo sapiens_hsa04713	0.59452488
70	Purine metabolism_Homo sapiens_hsa00230	0.59340689
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56381693
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56155810
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56142515
74	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.56004737
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53071367
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51273381
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49873396
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47286360
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46043387
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.45855702
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44930811
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44497579
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.40438948
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39329849
85	GABAergic synapse_Homo sapiens_hsa04727	0.39280774
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39280067
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39271703
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.38021172
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.37166445
90	Regulation of autophagy_Homo sapiens_hsa04140	0.36910767
91	Serotonergic synapse_Homo sapiens_hsa04726	0.36720324
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36198758
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34522890
94	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.32625466
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28482337
96	Notch signaling pathway_Homo sapiens_hsa04330	0.26718627
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.26360745
98	Taste transduction_Homo sapiens_hsa04742	0.24536198
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23329166
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22781997

RPL13AP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »