ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	surfactant homeostasis (GO:0043129)	6.42336133
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.79590316
3	DNA deamination (GO:0045006)	5.36877468
4	somite development (GO:0061053)	5.14155917
5	axoneme assembly (GO:0035082)	5.08167623
6	regulation of cilium movement (GO:0003352)	4.99656588
7	epithelial cilium movement (GO:0003351)	4.79686503
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.76941067
9	chemical homeostasis within a tissue (GO:0048875)	4.76679861
10	protein polyglutamylation (GO:0018095)	4.69839294
11	cilium movement (GO:0003341)	4.64906686
12	axonemal dynein complex assembly (GO:0070286)	4.52236583
13	cilium or flagellum-dependent cell motility (GO:0001539)	4.48572671
14	response to pheromone (GO:0019236)	4.24689231
15	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	4.19251873
16	regulation of memory T cell differentiation (GO:0043380)	4.12125547
17	adaptation of signaling pathway (GO:0023058)	4.02666666
18	retinal cone cell development (GO:0046549)	4.01777639
19	nonmotile primary cilium assembly (GO:0035058)	3.91014810
20	cellular response to exogenous dsRNA (GO:0071360)	3.90701089
21	motile cilium assembly (GO:0044458)	3.84694310
22	production of molecular mediator involved in inflammatory response (GO:0002532)	3.83295201
23	reflex (GO:0060004)	3.60569103
24	activated T cell proliferation (GO:0050798)	3.50152375
25	striatum development (GO:0021756)	3.40887807
26	one-carbon compound transport (GO:0019755)	3.38699958
27	positive T cell selection (GO:0043368)	3.38096874
28	regulation of vasculogenesis (GO:2001212)	3.36526939
29	glycosphingolipid biosynthetic process (GO:0006688)	3.32651590
30	cellular response to nitric oxide (GO:0071732)	3.29990592
31	leukotriene biosynthetic process (GO:0019370)	3.24464992
32	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.22267517
33	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.18408132
34	lipoxygenase pathway (GO:0019372)	3.18196492
35	positive regulation of defense response to virus by host (GO:0002230)	3.17125436
36	regulation of microtubule-based movement (GO:0060632)	3.16255268
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.14674881
38	positive regulation of T cell cytokine production (GO:0002726)	3.14233386
39	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.13912402
40	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.13692595
41	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.09078751
42	left/right axis specification (GO:0070986)	3.06096224
43	cytidine deamination (GO:0009972)	3.05170630
44	cytidine metabolic process (GO:0046087)	3.05170630
45	cytidine catabolic process (GO:0006216)	3.05170630
46	neuronal action potential propagation (GO:0019227)	3.04693463
47	regulation of immunoglobulin secretion (GO:0051023)	2.98484913
48	kidney morphogenesis (GO:0060993)	2.97357240
49	rRNA modification (GO:0000154)	2.95453806
50	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.94683951
51	regulation of regulatory T cell differentiation (GO:0045589)	2.94399037
52	detection of light stimulus involved in sensory perception (GO:0050962)	2.94324899
53	detection of light stimulus involved in visual perception (GO:0050908)	2.94324899
54	cellular response to interferon-beta (GO:0035458)	2.93911162
55	negative T cell selection (GO:0043383)	2.92938981
56	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90862660
57	NAD biosynthetic process (GO:0009435)	2.88479136
58	urate metabolic process (GO:0046415)	2.86296248
59	response to gravity (GO:0009629)	2.84694131
60	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.80324999
61	positive regulation of vasculogenesis (GO:2001214)	2.80301828
62	indolalkylamine metabolic process (GO:0006586)	2.78715262
63	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.78136755
64	GPI anchor metabolic process (GO:0006505)	2.77229231
65	pyrimidine nucleobase catabolic process (GO:0006208)	2.71691778
66	negative regulation of response to food (GO:0032096)	2.71271886
67	negative regulation of appetite (GO:0032099)	2.71271886
68	positive regulation of T cell differentiation in thymus (GO:0033089)	2.69149577
69	valine metabolic process (GO:0006573)	2.68838295
70	positive regulation of phosphatase activity (GO:0010922)	2.68159081
71	cilium morphogenesis (GO:0060271)	2.67340742
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.67034780
73	regulation of appetite (GO:0032098)	2.61212210
74	respiratory gaseous exchange (GO:0007585)	2.60780781
75	tryptophan catabolic process (GO:0006569)	2.58715696
76	indole-containing compound catabolic process (GO:0042436)	2.58715696
77	indolalkylamine catabolic process (GO:0046218)	2.58715696
78	cellular response to leptin stimulus (GO:0044320)	2.58121302
79	response to interferon-beta (GO:0035456)	2.57619725
80	ATP synthesis coupled proton transport (GO:0015986)	2.56591726
81	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.56591726
82	sodium ion homeostasis (GO:0055078)	2.55658141
83	negative regulation of mast cell activation (GO:0033004)	2.53624950
84	cilium organization (GO:0044782)	2.52167343
85	glycolipid biosynthetic process (GO:0009247)	2.51911460
86	arachidonic acid secretion (GO:0050482)	2.50980753
87	icosanoid secretion (GO:0032309)	2.50980753
88	thalamus development (GO:0021794)	2.49023109
89	protein homotrimerization (GO:0070207)	2.48381928
90	cellular ketone body metabolic process (GO:0046950)	2.48308456
91	organelle membrane fusion (GO:0090174)	2.48223154
92	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.47828629
93	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.47492004
94	cellular response to reactive nitrogen species (GO:1902170)	2.47355556
95	negative regulation of T-helper cell differentiation (GO:0045623)	2.47031501
96	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.47031501
97	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.46554862
98	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.46233088
99	regulation of response to food (GO:0032095)	2.42531035
100	regulation of defense response to virus by host (GO:0050691)	2.42493141

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.49028489
2	VDR_22108803_ChIP-Seq_LS180_Human	4.14870392
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.17223771
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.97100594
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.74051727
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54840058
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.53739820
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.50134634
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.40769253
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.36828241
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.08135587
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.06094213
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.00142964
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.97236484
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.89621204
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89172570
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87245294
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.84198828
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.81027811
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.81027811
21	* ER_23166858_ChIP-Seq_MCF-7_Human	1.78582671
22	P300_19829295_ChIP-Seq_ESCs_Human	1.77965226
23	EWS_26573619_Chip-Seq_HEK293_Human	1.74905532
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.68691376
25	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.64823168
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.60428633
27	FUS_26573619_Chip-Seq_HEK293_Human	1.60023833
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59630764
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58358574
30	TCF4_22108803_ChIP-Seq_LS180_Human	1.53118325
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52686014
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52255523
33	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.50990082
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49469432
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48129800
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48036358
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46705905
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41704930
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.37408629
40	STAT3_23295773_ChIP-Seq_U87_Human	1.36513171
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.35854757
42	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.33651272
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28964965
44	AR_20517297_ChIP-Seq_VCAP_Human	1.25482665
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.24637142
46	AR_25329375_ChIP-Seq_VCAP_Human	1.24544784
47	TCF4_23295773_ChIP-Seq_U87_Human	1.24529723
48	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24351833
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23851395
50	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23145006
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22292325
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22178422
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22142640
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.21116232
55	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20685444
56	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18071412
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17804065
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17479436
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17479436
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16531650
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15878323
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15018973
63	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14132340
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12763533
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12529419
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12529419
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12417640
68	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.12245801
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11173696
70	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.10704508
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09378642
72	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08776045
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08582622
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08143000
75	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.07925357
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06797581
77	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.06545876
78	DROSHA_22980978_ChIP-Seq_HELA_Human	1.06408790
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06349354
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06210394
81	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.05245272
82	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04244204
83	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02807042
84	OCT4_20526341_ChIP-Seq_ESCs_Human	1.01714248
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00350656
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99539246
87	* SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99327861
88	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.98428190
89	CDX2_22108803_ChIP-Seq_LS180_Human	0.98303249
90	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.98065733
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97848573
92	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97456925
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96601895
94	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.96487027
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95884996
96	NCOR_22424771_ChIP-Seq_293T_Human	0.93488103
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93487198
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93358610
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92989205
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92372263

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004782_abnormal_surfactant_physiolog	3.70457206
2	MP0008995_early_reproductive_senescence	3.25335966
3	MP0001986_abnormal_taste_sensitivity	3.24421582
4	MP0003950_abnormal_plasma_membrane	2.74232957
5	MP0001984_abnormal_olfaction	2.64570564
6	MP0003724_increased_susceptibility_to	2.63939024
7	MP0001968_abnormal_touch/_nociception	2.58919648
8	MP0005671_abnormal_response_to	2.56955530
9	MP0005423_abnormal_somatic_nervous	2.48570510
10	MP0002736_abnormal_nociception_after	2.46063915
11	MP0005551_abnormal_eye_electrophysiolog	2.25620380
12	MP0002254_reproductive_system_inflammat	2.22984768
13	MP0001958_emphysema	2.12071288
14	MP0001486_abnormal_startle_reflex	2.07736128
15	MP0003195_calcinosis	1.98064586
16	MP0002653_abnormal_ependyma_morphology	1.95385633
17	MP0008058_abnormal_DNA_repair	1.94553927
18	MP0002102_abnormal_ear_morphology	1.91016942
19	MP0005646_abnormal_pituitary_gland	1.88819576
20	MP0005253_abnormal_eye_physiology	1.80998020
21	MP0001501_abnormal_sleep_pattern	1.76642992
22	MP0006292_abnormal_olfactory_placode	1.71043507
23	MP0003436_decreased_susceptibility_to	1.66457147
24	MP0002234_abnormal_pharynx_morphology	1.65488167
25	MP0002876_abnormal_thyroid_physiology	1.60521021
26	MP0004145_abnormal_muscle_electrophysio	1.53560899
27	MP0000613_abnormal_salivary_gland	1.52247707
28	MP0002090_abnormal_vision	1.51751274
29	MP0009379_abnormal_foot_pigmentation	1.51498862
30	MP0005084_abnormal_gallbladder_morpholo	1.50446844
31	MP0002148_abnormal_hypersensitivity_rea	1.47553023
32	MP0002733_abnormal_thermal_nociception	1.46351352
33	MP0001440_abnormal_grooming_behavior	1.45290444
34	MP0000569_abnormal_digit_pigmentation	1.45214144
35	MP0001542_abnormal_bone_strength	1.37036081
36	MP0001970_abnormal_pain_threshold	1.36681591
37	MP0003866_abnormal_defecation	1.34916697
38	MP0001790_abnormal_immune_system	1.32386360
39	MP0005387_immune_system_phenotype	1.32386360
40	MP0002272_abnormal_nervous_system	1.30047665
41	MP0009053_abnormal_anal_canal	1.29706171
42	MP0005085_abnormal_gallbladder_physiolo	1.26263437
43	MP0005636_abnormal_mineral_homeostasis	1.21379855
44	MP0002282_abnormal_trachea_morphology	1.19497244
45	MP0009785_altered_susceptibility_to	1.19377278
46	MP0008789_abnormal_olfactory_epithelium	1.19267385
47	MP0005647_abnormal_sex_gland	1.17868155
48	MP0003283_abnormal_digestive_organ	1.17079859
49	MP0008004_abnormal_stomach_pH	1.15266487
50	MP0004885_abnormal_endolymph	1.15180662
51	MP0001346_abnormal_lacrimal_gland	1.13744469
52	MP0005332_abnormal_amino_acid	1.13606830
53	MP0001502_abnormal_circadian_rhythm	1.13352754
54	MP0005195_abnormal_posterior_eye	1.10615872
55	MP0002166_altered_tumor_susceptibility	1.10290587
56	MP0002734_abnormal_mechanical_nocicepti	1.09337961
57	MP0002572_abnormal_emotion/affect_behav	1.08994312
58	MP0001529_abnormal_vocalization	1.06630258
59	MP0001835_abnormal_antigen_presentation	1.05703970
60	MP0003137_abnormal_impulse_conducting	1.02933682
61	MP0005310_abnormal_salivary_gland	1.02589220
62	MP0001905_abnormal_dopamine_level	1.01732284
63	MP0000685_abnormal_immune_system	1.00343185
64	MP0002095_abnormal_skin_pigmentation	0.99309143
65	MP0002006_tumorigenesis	0.97630819
66	MP0005174_abnormal_tail_pigmentation	0.96084895
67	MP0005388_respiratory_system_phenotype	0.94707709
68	MP0002133_abnormal_respiratory_system	0.94707709
69	MP0002138_abnormal_hepatobiliary_system	0.93023814
70	MP0006072_abnormal_retinal_apoptosis	0.92873842
71	MP0001853_heart_inflammation	0.92124233
72	MP0002557_abnormal_social/conspecific_i	0.90600858
73	MP0005360_urolithiasis	0.88943920
74	MP0004142_abnormal_muscle_tone	0.87931185
75	MP0009643_abnormal_urine_homeostasis	0.87744663
76	MP0000631_abnormal_neuroendocrine_gland	0.87672418
77	MP0002168_other_aberrant_phenotype	0.87605505
78	MP0000639_abnormal_adrenal_gland	0.85902846
79	MP0009046_muscle_twitch	0.83824228
80	MP0010329_abnormal_lipoprotein_level	0.83292336
81	MP0002064_seizures	0.83066523
82	MP0003786_premature_aging	0.82404735
83	MP0000372_irregular_coat_pigmentation	0.79018955
84	MP0005167_abnormal_blood-brain_barrier	0.77775627
85	MP0010368_abnormal_lymphatic_system	0.77709630
86	MP0003136_yellow_coat_color	0.77264809
87	MP0001765_abnormal_ion_homeostasis	0.76640156
88	MP0003878_abnormal_ear_physiology	0.75433764
89	MP0005377_hearing/vestibular/ear_phenot	0.75433764
90	MP0001293_anophthalmia	0.75345379
91	MP0001664_abnormal_digestion	0.74809352
92	MP0002405_respiratory_system_inflammati	0.74182425
93	MP0000427_abnormal_hair_cycle	0.74021571
94	MP0003045_fibrosis	0.73049632
95	MP0009745_abnormal_behavioral_response	0.72179052
96	MP0001533_abnormal_skeleton_physiology	0.70411198
97	MP0005000_abnormal_immune_tolerance	0.69379125
98	MP0002067_abnormal_sensory_capabilities	0.68667074
99	MP0004043_abnormal_pH_regulation	0.68490837
100	MP0002063_abnormal_learning/memory/cond	0.66882664

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.67321835
2	Absent/shortened dynein arms (HP:0200106)	5.67321835
3	Interstitial pulmonary disease (HP:0006530)	4.85875574
4	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	4.77659139
5	Visual hallucinations (HP:0002367)	4.44200113
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.43849416
7	Abnormal respiratory epithelium morphology (HP:0012253)	4.21343262
8	Abnormal respiratory motile cilium morphology (HP:0005938)	4.21343262
9	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.19089805
10	Abnormal ciliary motility (HP:0012262)	4.14403838
11	Chronic bronchitis (HP:0004469)	4.09717396
12	Prostate neoplasm (HP:0100787)	3.85679007
13	Abnormal respiratory motile cilium physiology (HP:0012261)	3.70397446
14	Increased cerebral lipofuscin (HP:0011813)	3.48567685
15	Testicular atrophy (HP:0000029)	3.38733554
16	Tachypnea (HP:0002789)	3.37652154
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.34461304
18	Tubulointerstitial fibrosis (HP:0005576)	3.31142717
19	Medial flaring of the eyebrow (HP:0010747)	3.30973247
20	Autoimmune thrombocytopenia (HP:0001973)	3.21979049
21	Abnormality of the renal cortex (HP:0011035)	3.17167974
22	Elevated erythrocyte sedimentation rate (HP:0003565)	3.17041203
23	Methylmalonic acidemia (HP:0002912)	3.08354295
24	Abnormal rod and cone electroretinograms (HP:0008323)	3.02411844
25	Renal cortical cysts (HP:0000803)	2.94605943
26	Exertional dyspnea (HP:0002875)	2.91426552
27	Molar tooth sign on MRI (HP:0002419)	2.89169643
28	Abnormality of midbrain morphology (HP:0002418)	2.89169643
29	Pancreatic cysts (HP:0001737)	2.87014630
30	Alveolar cell carcinoma (HP:0006519)	2.86819351
31	Asplenia (HP:0001746)	2.84654962
32	Abnormality of the prostate (HP:0008775)	2.81512865
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.80763801
34	Tubulointerstitial abnormality (HP:0001969)	2.79927656
35	Rhinitis (HP:0012384)	2.78070586
36	Congenital stationary night blindness (HP:0007642)	2.69007751
37	Pancreatic fibrosis (HP:0100732)	2.67163707
38	Nephronophthisis (HP:0000090)	2.64238040
39	Abolished electroretinogram (ERG) (HP:0000550)	2.52361154
40	Autoimmune hemolytic anemia (HP:0001890)	2.48633184
41	Decreased circulating renin level (HP:0003351)	2.47018922
42	Polydipsia (HP:0001959)	2.44044372
43	Abnormal drinking behavior (HP:0030082)	2.44044372
44	True hermaphroditism (HP:0010459)	2.42571341
45	Neoplasm of the tracheobronchial system (HP:0100552)	2.41472726
46	Tubulointerstitial nephritis (HP:0001970)	2.31754609
47	Abnormality of the renal medulla (HP:0100957)	2.28774609
48	3-Methylglutaconic aciduria (HP:0003535)	2.26054391
49	Bronchiectasis (HP:0002110)	2.24106289
50	Tubular atrophy (HP:0000092)	2.23270653
51	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.20478117
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.18685934
53	Hypoplasia of the fovea (HP:0007750)	2.18685934
54	Pulmonary fibrosis (HP:0002206)	2.18033517
55	Congenital primary aphakia (HP:0007707)	2.14375347
56	Hypoproteinemia (HP:0003075)	2.13194882
57	Focal motor seizures (HP:0011153)	2.09889835
58	Gait imbalance (HP:0002141)	2.09112846
59	Adactyly (HP:0009776)	2.08648286
60	Spastic diplegia (HP:0001264)	2.07344196
61	Respiratory distress (HP:0002098)	2.07185064
62	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.06388275
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.06388275
64	Bronchitis (HP:0012387)	2.05825442
65	Hemiparesis (HP:0001269)	2.03073407
66	Hyperactive renin-angiotensin system (HP:0000841)	1.99883395
67	Abnormality of vitamin B metabolism (HP:0004340)	1.98456679
68	Nephrogenic diabetes insipidus (HP:0009806)	1.97546368
69	Termporal pattern (HP:0011008)	1.96766476
70	Insidious onset (HP:0003587)	1.96766476
71	Chronic hepatic failure (HP:0100626)	1.95527703
72	Opisthotonus (HP:0002179)	1.90548222
73	Systemic lupus erythematosus (HP:0002725)	1.87808659
74	Panhypogammaglobulinemia (HP:0003139)	1.87798959
75	Acute necrotizing encephalopathy (HP:0006965)	1.86338461
76	Methylmalonic aciduria (HP:0012120)	1.84732687
77	Abnormality of purine metabolism (HP:0004352)	1.84054436
78	Abnormality of the fovea (HP:0000493)	1.82043098
79	Attenuation of retinal blood vessels (HP:0007843)	1.81982050
80	Abnormal number of erythroid precursors (HP:0012131)	1.81937056
81	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.81879231
82	Central scotoma (HP:0000603)	1.81768713
83	Renal salt wasting (HP:0000127)	1.80949614
84	Polyuria (HP:0000103)	1.78478495
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78132692
86	Abnormality of alanine metabolism (HP:0010916)	1.78132692
87	Hyperalaninemia (HP:0003348)	1.78132692
88	Abnormality of the fingertips (HP:0001211)	1.77182007
89	Parakeratosis (HP:0001036)	1.76569526
90	Cystic liver disease (HP:0006706)	1.76508891
91	Constricted visual fields (HP:0001133)	1.73831081
92	Abnormality of renin-angiotensin system (HP:0000847)	1.72253111
93	Thyroiditis (HP:0100646)	1.72073101
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.70250600
95	Dyschromatopsia (HP:0007641)	1.67596447
96	Papilledema (HP:0001085)	1.67205757
97	Abnormality of T cell physiology (HP:0011840)	1.66954163
98	Abnormality of cells of the erythroid lineage (HP:0012130)	1.66363731
99	Pheochromocytoma (HP:0002666)	1.65138843
100	Optic disc pallor (HP:0000543)	1.61992330

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.44856476
2	FRK	3.79115019
3	MAP4K2	3.34373412
4	TLK1	3.21250059
5	EPHA3	3.06151955
6	MST4	2.57044401
7	TIE1	2.03003876
8	DAPK2	2.01380563
9	PINK1	2.00625582
10	MAP4K1	1.75569129
11	MKNK1	1.75445673
12	MAPK15	1.64652419
13	FES	1.55113979
14	GRK1	1.53008568
15	NEK1	1.52829261
16	EPHB2	1.51796332
17	PKN2	1.51319260
18	AKT3	1.49922010
19	BMPR2	1.49718973
20	ADRBK2	1.47442508
21	BCKDK	1.45471867
22	MAPKAPK3	1.43312368
23	NUAK1	1.37515725
24	MYLK	1.36419520
25	ZAK	1.35307933
26	WNK3	1.32939143
27	TAOK3	1.28434726
28	IKBKB	1.20847893
29	RPS6KA5	1.19411636
30	WEE1	1.12246179
31	JAK1	1.11244607
32	BMPR1B	1.10256742
33	MAPK13	1.05094731
34	STK24	1.04098917
35	PNCK	1.01367020
36	GRK7	0.93234616
37	PAK3	0.92513546
38	PIK3CA	0.92396074
39	MAPKAPK5	0.91983676
40	DAPK1	0.89533705
41	CASK	0.89483819
42	PRKCG	0.85980389
43	INSRR	0.85894511
44	CAMK2A	0.85055252
45	CSNK1A1L	0.84901883
46	TBK1	0.81473200
47	PRKCQ	0.80294198
48	ZAP70	0.80041622
49	WNK4	0.79061993
50	KIT	0.78236029
51	FLT3	0.77107827
52	GRK5	0.76901704
53	CHUK	0.76800039
54	CAMK2G	0.74245789
55	PRKCE	0.73752828
56	SRPK1	0.70910574
57	TGFBR1	0.69055742
58	ERBB2	0.68483519
59	TRIM28	0.66164072
60	LYN	0.65772000
61	STK38L	0.64603530
62	CAMK2D	0.63040020
63	CSNK1G3	0.59418396
64	CSNK1G2	0.58893756
65	LRRK2	0.58034681
66	CAMKK2	0.57463743
67	ADRBK1	0.56619769
68	PTK2B	0.56238573
69	TGFBR2	0.55810579
70	BCR	0.54720903
71	JAK2	0.54306998
72	TNK2	0.53559259
73	PRKCA	0.53289823
74	DYRK2	0.53091838
75	SYK	0.51974067
76	PRKACA	0.51856299
77	MAP3K12	0.51224725
78	PRKCI	0.50028146
79	CSNK1G1	0.49874520
80	NME2	0.49194700
81	STK16	0.48691570
82	KDR	0.48264370
83	PRKACB	0.47330187
84	IGF1R	0.46350778
85	FER	0.46104687
86	IRAK1	0.44324400
87	CSNK2A1	0.44269217
88	ERBB3	0.44194831
89	SGK2	0.43854221
90	SGK1	0.41969344
91	BRSK2	0.41604329
92	EGFR	0.41526862
93	CSNK1A1	0.40714916
94	AURKA	0.40552838
95	MAPK7	0.40265789
96	GSK3A	0.39696938
97	TEC	0.38456461
98	SRC	0.37731703
99	CSK	0.36800814
100	TYK2	0.36427235

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.04067632
2	Asthma_Homo sapiens_hsa05310	3.03175090
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.00152353
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.75545524
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.45846074
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36358294
7	Phototransduction_Homo sapiens_hsa04744	2.32406193
8	Allograft rejection_Homo sapiens_hsa05330	2.27640570
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.23522953
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.22133139
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.16290124
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.00025686
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.88977436
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.76219044
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.72711282
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70432523
17	Histidine metabolism_Homo sapiens_hsa00340	1.70029190
18	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.67651942
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.66670368
20	Nicotine addiction_Homo sapiens_hsa05033	1.60483517
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.58473561
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.51541490
23	Mineral absorption_Homo sapiens_hsa04978	1.49450727
24	Protein export_Homo sapiens_hsa03060	1.46601719
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.45204039
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.38724763
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37506058
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.34078906
29	Taste transduction_Homo sapiens_hsa04742	1.32998110
30	Ribosome_Homo sapiens_hsa03010	1.30710207
31	Primary immunodeficiency_Homo sapiens_hsa05340	1.28779044
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.25714987
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22851499
34	Propanoate metabolism_Homo sapiens_hsa00640	1.21907737
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.20768606
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17776612
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.14895563
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13318085
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12181819
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.11116288
41	ABC transporters_Homo sapiens_hsa02010	1.04254901
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.01899521
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01825283
44	Parkinsons disease_Homo sapiens_hsa05012	1.00299419
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99850517
46	Pertussis_Homo sapiens_hsa05133	0.97905475
47	Huntingtons disease_Homo sapiens_hsa05016	0.96555383
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.93261050
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92998500
50	Butanoate metabolism_Homo sapiens_hsa00650	0.92703580
51	Salivary secretion_Homo sapiens_hsa04970	0.92483523
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.90793261
53	Regulation of autophagy_Homo sapiens_hsa04140	0.90115176
54	Serotonergic synapse_Homo sapiens_hsa04726	0.88082121
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87801669
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.85846933
57	Basal transcription factors_Homo sapiens_hsa03022	0.83257165
58	RNA degradation_Homo sapiens_hsa03018	0.81449551
59	RNA polymerase_Homo sapiens_hsa03020	0.80007207
60	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77788268
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74902647
62	Retinol metabolism_Homo sapiens_hsa00830	0.72437296
63	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.72049225
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.71515042
65	Morphine addiction_Homo sapiens_hsa05032	0.71469615
66	Alzheimers disease_Homo sapiens_hsa05010	0.71369885
67	Renin secretion_Homo sapiens_hsa04924	0.68052312
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.67806466
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66370784
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65726549
71	GABAergic synapse_Homo sapiens_hsa04727	0.64646773
72	Olfactory transduction_Homo sapiens_hsa04740	0.64112168
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63653243
74	Proteasome_Homo sapiens_hsa03050	0.63608751
75	Circadian entrainment_Homo sapiens_hsa04713	0.63594666
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63533052
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62827949
78	Homologous recombination_Homo sapiens_hsa03440	0.58935775
79	Caffeine metabolism_Homo sapiens_hsa00232	0.58750219
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58357183
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58229930
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.55672294
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.53939210
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49510511
85	Phagosome_Homo sapiens_hsa04145	0.47565811
86	Viral myocarditis_Homo sapiens_hsa05416	0.46070520
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.46050820
88	Herpes simplex infection_Homo sapiens_hsa05168	0.45135122
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.44304562
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43446623
91	Insulin secretion_Homo sapiens_hsa04911	0.42499909
92	Fatty acid degradation_Homo sapiens_hsa00071	0.42217759
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.41801756
94	One carbon pool by folate_Homo sapiens_hsa00670	0.41557122
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39820826
96	Amphetamine addiction_Homo sapiens_hsa05031	0.39456725
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38217738
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37415607
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.36802664
100	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.35121908

RPL13AP17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »