ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.39128906
2	DNA deamination (GO:0045006)	6.91705508
3	viral transcription (GO:0019083)	6.48065299
4	translational termination (GO:0006415)	6.18642181
5	cytidine metabolic process (GO:0046087)	5.71929872
6	cytidine catabolic process (GO:0006216)	5.71929872
7	cytidine deamination (GO:0009972)	5.71929872
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.68998972
9	ribosomal small subunit biogenesis (GO:0042274)	5.54032498
10	translational elongation (GO:0006414)	5.47194993
11	maturation of SSU-rRNA (GO:0030490)	5.46924955
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.29875107
13	cotranslational protein targeting to membrane (GO:0006613)	5.20378767
14	protein targeting to ER (GO:0045047)	5.17955980
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.93537245
16	protein localization to endoplasmic reticulum (GO:0070972)	4.89662591
17	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.86273508
18	viral life cycle (GO:0019058)	4.67567205
19	cellular protein complex disassembly (GO:0043624)	4.59746788
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.43592621
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.31550360
22	ATP synthesis coupled proton transport (GO:0015986)	4.31550360
23	translational initiation (GO:0006413)	4.14570921
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.14012801
25	ribosomal large subunit biogenesis (GO:0042273)	3.97605380
26	behavioral response to nicotine (GO:0035095)	3.91055750
27	protein complex disassembly (GO:0043241)	3.78861946
28	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.73268503
29	protein neddylation (GO:0045116)	3.66847951
30	metallo-sulfur cluster assembly (GO:0031163)	3.66366647
31	iron-sulfur cluster assembly (GO:0016226)	3.66366647
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.59032074
33	macromolecular complex disassembly (GO:0032984)	3.57951399
34	translation (GO:0006412)	3.54883263
35	protein complex biogenesis (GO:0070271)	3.54803331
36	positive regulation of prostaglandin secretion (GO:0032308)	3.46960211
37	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.46958987
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45177523
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45177523
40	NADH dehydrogenase complex assembly (GO:0010257)	3.45177523
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.39241290
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.39241290
43	protein targeting to membrane (GO:0006612)	3.37408116
44	pseudouridine synthesis (GO:0001522)	3.35850730
45	chaperone-mediated protein transport (GO:0072321)	3.34062283
46	ribonucleoprotein complex biogenesis (GO:0022613)	3.28871985
47	base-excision repair, AP site formation (GO:0006285)	3.21880631
48	electron transport chain (GO:0022900)	3.21678826
49	cellular component biogenesis (GO:0044085)	3.18488087
50	respiratory electron transport chain (GO:0022904)	3.17753358
51	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.10379689
52	mitochondrial respiratory chain complex assembly (GO:0033108)	3.09665636
53	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.07799787
54	positive regulation of defense response to virus by host (GO:0002230)	3.07283134
55	pyrimidine nucleotide catabolic process (GO:0006244)	3.00168251
56	positive regulation of fatty acid transport (GO:2000193)	2.95347183
57	mRNA catabolic process (GO:0006402)	2.92042932
58	preassembly of GPI anchor in ER membrane (GO:0016254)	2.91829454
59	deoxyribonucleotide catabolic process (GO:0009264)	2.91692276
60	pyrimidine nucleoside catabolic process (GO:0046135)	2.89884973
61	water-soluble vitamin biosynthetic process (GO:0042364)	2.89242596
62	GPI anchor metabolic process (GO:0006505)	2.87198364
63	ubiquinone biosynthetic process (GO:0006744)	2.84347608
64	regulation of regulatory T cell differentiation (GO:0045589)	2.82266784
65	positive regulation of icosanoid secretion (GO:0032305)	2.77864901
66	positive thymic T cell selection (GO:0045059)	2.77847058
67	GPI anchor biosynthetic process (GO:0006506)	2.77845856
68	positive regulation of respiratory burst (GO:0060267)	2.76995171
69	deoxyribose phosphate catabolic process (GO:0046386)	2.76290653
70	positive T cell selection (GO:0043368)	2.74118646
71	negative regulation by host of viral transcription (GO:0043922)	2.71835055
72	sequestering of actin monomers (GO:0042989)	2.68977708
73	mannosylation (GO:0097502)	2.68665251
74	negative regulation of telomere maintenance (GO:0032205)	2.68282345
75	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.62384122
76	RNA catabolic process (GO:0006401)	2.61318641
77	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60493757
78	positive regulation of calcium-mediated signaling (GO:0050850)	2.59794200
79	positive regulation of T cell apoptotic process (GO:0070234)	2.58723405
80	negative T cell selection (GO:0043383)	2.58717724
81	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.57420927
82	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.56761878
83	piRNA metabolic process (GO:0034587)	2.56682265
84	ATP biosynthetic process (GO:0006754)	2.56471901
85	purine deoxyribonucleotide catabolic process (GO:0009155)	2.55457497
86	regulation of prostaglandin secretion (GO:0032306)	2.55209426
87	ncRNA 3-end processing (GO:0043628)	2.55132295
88	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.54831327
89	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.53368474
90	rRNA processing (GO:0006364)	2.52181787
91	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.51268402
92	rRNA metabolic process (GO:0016072)	2.50343242
93	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.49482322
94	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.49194344
95	response to pheromone (GO:0019236)	2.48861714
96	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.48770075
97	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.46192388
98	platelet dense granule organization (GO:0060155)	2.46012038
99	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45855353
100	DNA demethylation (GO:0080111)	2.45264671

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.38451403
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.37123542
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.27160968
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.99635209
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.73891422
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69936197
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.55263259
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.48041798
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.46261122
10	VDR_22108803_ChIP-Seq_LS180_Human	2.44631346
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43015511
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42336296
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39373739
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34542976
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.32679174
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22029667
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.09919979
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05896589
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.02085560
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.99777578
21	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.85231416
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73074271
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.71216573
24	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.67307230
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.65247047
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60399529
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57260570
28	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.57022879
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.55527039
30	* TP53_22573176_ChIP-Seq_HFKS_Human	1.55292423
31	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.51068942
32	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.50087817
33	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.47921843
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.46585336
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45713791
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45145702
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43813979
38	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.38103509
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37181716
40	BCL6_27268052_Chip-Seq_Bcells_Human	1.35819858
41	NCOR_22424771_ChIP-Seq_293T_Human	1.33749020
42	AR_20517297_ChIP-Seq_VCAP_Human	1.32868576
43	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.31527393
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.31329322
45	GATA3_26560356_Chip-Seq_TH2_Human	1.30979762
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28666565
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27494965
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27494965
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26342613
50	ERA_21632823_ChIP-Seq_H3396_Human	1.25943825
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25509636
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.25433694
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24942723
54	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.23394676
55	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.19131947
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.18911548
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18446859
58	MYB_26560356_Chip-Seq_TH2_Human	1.18296856
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16875526
60	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.16682218
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.14074283
62	ELK1_19687146_ChIP-ChIP_HELA_Human	1.14070068
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12274218
64	* EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.12173911
65	EWS_26573619_Chip-Seq_HEK293_Human	1.10794918
66	P300_27268052_Chip-Seq_Bcells_Human	1.09561077
67	RUNX_20019798_ChIP-Seq_JUKART_Human	1.09043634
68	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08572274
69	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08408759
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06973332
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06699531
72	GATA3_27048872_Chip-Seq_THYMUS_Human	1.06620004
73	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.06096884
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05671892
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05167214
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.04908306
77	E2F1_20622854_ChIP-Seq_HELA_Human	1.04362673
78	ERG_20517297_ChIP-Seq_VCAP_Human	1.04193913
79	TTF2_22483619_ChIP-Seq_HELA_Human	1.03246949
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02874415
81	STAT1_20625510_ChIP-Seq_HELA_Human	1.02748302
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00637818
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.00043457
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99827681
85	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.99419173
86	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99179926
87	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99144440
88	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98350732
89	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.97983302
90	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96331253
91	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.96274028
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96164689
93	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96053123
94	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.95830437
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95136402
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95136402
97	ER_23166858_ChIP-Seq_MCF-7_Human	0.94964160
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94963707
99	SA1_27219007_Chip-Seq_Bcells_Human	0.94718804
100	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93519327

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.04750612
2	MP0005671_abnormal_response_to	3.84371354
3	MP0006292_abnormal_olfactory_placode	3.46846221
4	MP0004147_increased_porphyrin_level	2.92657051
5	MP0003646_muscle_fatigue	2.80536749
6	MP0002102_abnormal_ear_morphology	2.68728561
7	MP0009333_abnormal_splenocyte_physiolog	2.07734132
8	MP0002837_dystrophic_cardiac_calcinosis	2.06018796
9	MP0009785_altered_susceptibility_to	1.94941037
10	MP0005645_abnormal_hypothalamus_physiol	1.93657761
11	MP0008872_abnormal_physiological_respon	1.90274772
12	MP0005646_abnormal_pituitary_gland	1.86208923
13	MP0006072_abnormal_retinal_apoptosis	1.80896047
14	MP0001968_abnormal_touch/_nociception	1.78941374
15	MP0001835_abnormal_antigen_presentation	1.75210306
16	MP0002163_abnormal_gland_morphology	1.74489397
17	MP0005551_abnormal_eye_electrophysiolog	1.65157245
18	MP0001873_stomach_inflammation	1.63153314
19	MP0001800_abnormal_humoral_immune	1.61430495
20	MP0001905_abnormal_dopamine_level	1.58224055
21	MP0002148_abnormal_hypersensitivity_rea	1.57993617
22	MP0003011_delayed_dark_adaptation	1.55419359
23	MP0002653_abnormal_ependyma_morphology	1.53598969
24	MP0004885_abnormal_endolymph	1.48538447
25	MP0002876_abnormal_thyroid_physiology	1.47792582
26	MP0004145_abnormal_muscle_electrophysio	1.46179344
27	MP0005000_abnormal_immune_tolerance	1.43895695
28	MP0003763_abnormal_thymus_physiology	1.42154430
29	MP0002723_abnormal_immune_serum	1.41569127
30	MP0001986_abnormal_taste_sensitivity	1.40043340
31	MP0005389_reproductive_system_phenotype	1.39878605
32	MP0008875_abnormal_xenobiotic_pharmacok	1.39004060
33	MP0002160_abnormal_reproductive_system	1.37579649
34	MP0005075_abnormal_melanosome_morpholog	1.35910609
35	MP0001790_abnormal_immune_system	1.32428446
36	MP0005387_immune_system_phenotype	1.32428446
37	MP0005084_abnormal_gallbladder_morpholo	1.31960057
38	MP0005377_hearing/vestibular/ear_phenot	1.30987267
39	MP0003878_abnormal_ear_physiology	1.30987267
40	MP0002420_abnormal_adaptive_immunity	1.29503742
41	MP0000372_irregular_coat_pigmentation	1.28716888
42	MP0001819_abnormal_immune_cell	1.25377528
43	MP0004142_abnormal_muscle_tone	1.24453544
44	MP0000678_abnormal_parathyroid_gland	1.21895560
45	MP0002234_abnormal_pharynx_morphology	1.21683607
46	MP0002095_abnormal_skin_pigmentation	1.21617061
47	MP0006276_abnormal_autonomic_nervous	1.19775413
48	MP0005025_abnormal_response_to	1.18611814
49	MP0002638_abnormal_pupillary_reflex	1.18201771
50	MP0008877_abnormal_DNA_methylation	1.16923405
51	MP0003195_calcinosis	1.14718164
52	MP0002736_abnormal_nociception_after	1.13035583
53	MP0000685_abnormal_immune_system	1.12574602
54	MP0003806_abnormal_nucleotide_metabolis	1.12434389
55	MP0001919_abnormal_reproductive_system	1.12131944
56	MP0005253_abnormal_eye_physiology	1.11751120
57	MP0000049_abnormal_middle_ear	1.11237248
58	MP0009764_decreased_sensitivity_to	1.07548760
59	MP0003866_abnormal_defecation	1.06571721
60	MP0002452_abnormal_antigen_presenting	1.03911421
61	MP0002138_abnormal_hepatobiliary_system	1.00356651
62	MP0000716_abnormal_immune_system	0.99581471
63	MP0002735_abnormal_chemical_nociception	0.97967945
64	MP0001764_abnormal_homeostasis	0.96836540
65	MP0003186_abnormal_redox_activity	0.96830015
66	MP0005410_abnormal_fertilization	0.94385008
67	MP0009745_abnormal_behavioral_response	0.94247385
68	MP0008789_abnormal_olfactory_epithelium	0.93315761
69	MP0002398_abnormal_bone_marrow	0.93215034
70	MP0002405_respiratory_system_inflammati	0.92344609
71	MP0002272_abnormal_nervous_system	0.92264558
72	MP0003786_premature_aging	0.91401640
73	MP0003880_abnormal_central_pattern	0.90851001
74	MP0001485_abnormal_pinna_reflex	0.89646621
75	MP0008995_early_reproductive_senescence	0.88768001
76	MP0005379_endocrine/exocrine_gland_phen	0.87769556
77	MP0004043_abnormal_pH_regulation	0.87683226
78	MP0000631_abnormal_neuroendocrine_gland	0.87064778
79	MP0002277_abnormal_respiratory_mucosa	0.86652910
80	MP0008058_abnormal_DNA_repair	0.85563414
81	MP0002733_abnormal_thermal_nociception	0.85140256
82	MP0001845_abnormal_inflammatory_respons	0.84896848
83	MP0003137_abnormal_impulse_conducting	0.83818442
84	MP0003787_abnormal_imprinting	0.83498918
85	MP0001963_abnormal_hearing_physiology	0.82822801
86	MP0000689_abnormal_spleen_morphology	0.82338031
87	MP0005360_urolithiasis	0.82037399
88	MP0001348_abnormal_lacrimal_gland	0.81325979
89	MP0002933_joint_inflammation	0.81089110
90	MP0009643_abnormal_urine_homeostasis	0.80048393
91	MP0005174_abnormal_tail_pigmentation	0.79824923
92	MP0004742_abnormal_vestibular_system	0.79657171
93	MP0005636_abnormal_mineral_homeostasis	0.79407707
94	MP0006036_abnormal_mitochondrial_physio	0.79019392
95	MP0001970_abnormal_pain_threshold	0.78899801
96	MP0001663_abnormal_digestive_system	0.78820013
97	MP0000230_abnormal_systemic_arterial	0.78124790
98	MP0010155_abnormal_intestine_physiology	0.76727559
99	MP0008469_abnormal_protein_level	0.75681683
100	MP0002429_abnormal_blood_cell	0.74835187

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.05694705
2	Abnormality of cells of the erythroid lineage (HP:0012130)	3.98346546
3	Acute necrotizing encephalopathy (HP:0006965)	3.93511663
4	Congenital stationary night blindness (HP:0007642)	3.85049160
5	Mitochondrial inheritance (HP:0001427)	3.80748074
6	Reticulocytopenia (HP:0001896)	3.66493753
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.59068651
8	Abnormal number of erythroid precursors (HP:0012131)	3.57414379
9	Acute encephalopathy (HP:0006846)	3.41210499
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.35451909
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.34322304
12	Hepatocellular necrosis (HP:0001404)	3.31755013
13	Pancreatic cysts (HP:0001737)	3.25357326
14	Increased CSF lactate (HP:0002490)	3.25260060
15	Aplastic anemia (HP:0001915)	3.18987158
16	IgG deficiency (HP:0004315)	3.17728486
17	Severe combined immunodeficiency (HP:0004430)	3.15441290
18	Progressive macrocephaly (HP:0004481)	3.15011466
19	Abnormality of midbrain morphology (HP:0002418)	3.06328546
20	Molar tooth sign on MRI (HP:0002419)	3.06328546
21	Increased hepatocellular lipid droplets (HP:0006565)	3.04945069
22	Lipid accumulation in hepatocytes (HP:0006561)	3.02921793
23	Macrocytic anemia (HP:0001972)	2.98140357
24	Increased intramyocellular lipid droplets (HP:0012240)	2.90894209
25	Renal Fanconi syndrome (HP:0001994)	2.89005744
26	Hepatic necrosis (HP:0002605)	2.88329222
27	3-Methylglutaconic aciduria (HP:0003535)	2.81031517
28	Pancreatic fibrosis (HP:0100732)	2.80351532
29	Pallor (HP:0000980)	2.73233660
30	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.73153523
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.73153523
32	True hermaphroditism (HP:0010459)	2.71836977
33	Optic disc pallor (HP:0000543)	2.66698395
34	Abolished electroretinogram (ERG) (HP:0000550)	2.62808886
35	Cerebral edema (HP:0002181)	2.61156206
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.60768630
37	Increased muscle lipid content (HP:0009058)	2.60567487
38	Hypoproteinemia (HP:0003075)	2.48012992
39	Pendular nystagmus (HP:0012043)	2.46896627
40	Microretrognathia (HP:0000308)	2.44653659
41	Abnormality of B cell number (HP:0010975)	2.41576414
42	Attenuation of retinal blood vessels (HP:0007843)	2.40415977
43	Panhypogammaglobulinemia (HP:0003139)	2.40296827
44	Decreased central vision (HP:0007663)	2.39157095
45	Thyroiditis (HP:0100646)	2.37557243
46	T lymphocytopenia (HP:0005403)	2.35528014
47	Nephronophthisis (HP:0000090)	2.34584565
48	Increased serum lactate (HP:0002151)	2.31848379
49	Abnormality of T cell number (HP:0011839)	2.29569070
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.26992132
51	Combined immunodeficiency (HP:0005387)	2.25479793
52	Absent thumb (HP:0009777)	2.24436075
53	Type II lissencephaly (HP:0007260)	2.24133757
54	Increased IgM level (HP:0003496)	2.21697046
55	Lactic acidosis (HP:0003128)	2.21258405
56	Stenosis of the external auditory canal (HP:0000402)	2.19448237
57	Exertional dyspnea (HP:0002875)	2.17786097
58	Polydipsia (HP:0001959)	2.16874055
59	Abnormal drinking behavior (HP:0030082)	2.16874055
60	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.14428272
61	B lymphocytopenia (HP:0010976)	2.13904759
62	Agammaglobulinemia (HP:0004432)	2.13442552
63	Abnormality of T cells (HP:0002843)	2.11811139
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.09948013
65	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07494118
66	Abnormal respiratory epithelium morphology (HP:0012253)	2.07494118
67	Abnormality of the renal cortex (HP:0011035)	2.06286278
68	Asplenia (HP:0001746)	2.05145717
69	Constricted visual fields (HP:0001133)	2.02808887
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01539281
71	Absent/shortened dynein arms (HP:0200106)	2.01539281
72	Abnormality of the prostate (HP:0008775)	2.00990647
73	Lethargy (HP:0001254)	1.99887758
74	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.98461586
75	Abnormality of DNA repair (HP:0003254)	1.94947891
76	Increased corneal curvature (HP:0100692)	1.92949486
77	Keratoconus (HP:0000563)	1.92949486
78	Abnormality of the renal medulla (HP:0100957)	1.92754551
79	Pancytopenia (HP:0001876)	1.92168490
80	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.91872527
81	Medial flaring of the eyebrow (HP:0010747)	1.91722300
82	Cystic liver disease (HP:0006706)	1.89304536
83	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.88116336
84	Hyperglycinemia (HP:0002154)	1.87828201
85	Birth length less than 3rd percentile (HP:0003561)	1.87633881
86	Respiratory failure (HP:0002878)	1.86180375
87	Autoimmune hemolytic anemia (HP:0001890)	1.84517859
88	Colon cancer (HP:0003003)	1.83697343
89	Polyuria (HP:0000103)	1.83562545
90	Encephalitis (HP:0002383)	1.82237917
91	Stomatitis (HP:0010280)	1.81788325
92	Type 2 muscle fiber atrophy (HP:0003554)	1.81733498
93	Abnormality of renal resorption (HP:0011038)	1.81376140
94	Abnormal ciliary motility (HP:0012262)	1.81360234
95	Abnormality of eosinophils (HP:0001879)	1.80833670
96	Glycosuria (HP:0003076)	1.79672484
97	Abnormality of urine glucose concentration (HP:0011016)	1.79672484
98	Chronic hepatic failure (HP:0100626)	1.78197580
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.77276530
100	Exercise intolerance (HP:0003546)	1.76610227

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.08318328
2	BCKDK	3.66418222
3	KDR	3.50991563
4	TESK2	3.32144911
5	ADRBK2	3.22247355
6	TLK1	2.72901495
7	MAP4K2	2.66613529
8	PASK	2.62125510
9	ZAK	2.52628485
10	GRK1	2.38926175
11	TAOK3	2.38118673
12	WNK4	2.32413592
13	MAP4K1	2.01785985
14	BMPR1B	1.98977205
15	CDK19	1.98452338
16	STK16	1.97998800
17	VRK2	1.84547641
18	NUAK1	1.65553320
19	TIE1	1.63228514
20	ITK	1.50500512
21	MUSK	1.49570382
22	TEC	1.49093388
23	PINK1	1.48364764
24	CAMKK1	1.48133451
25	DAPK2	1.46253006
26	MAP3K11	1.27100086
27	SYK	1.21521690
28	FRK	1.19913212
29	KIT	1.16577018
30	PRKCQ	1.12927052
31	VRK1	1.10657941
32	ADRBK1	1.10327391
33	LIMK1	1.08614182
34	NME1	1.08316845
35	IKBKB	1.06354143
36	FES	1.03566918
37	STK39	0.98267285
38	INSRR	0.96985318
39	BTK	0.95656764
40	SCYL2	0.94452782
41	DYRK2	0.92545491
42	IKBKE	0.91624111
43	LCK	0.89572696
44	PIM2	0.82903287
45	GRK6	0.81985970
46	GRK7	0.81857344
47	RPS6KA5	0.79942213
48	FLT3	0.76656881
49	ACVR1B	0.76491341
50	ABL2	0.75049429
51	MAP2K6	0.74868625
52	CAMKK2	0.74483303
53	NME2	0.74281366
54	WNK3	0.73419873
55	LYN	0.72033700
56	TNK2	0.70573436
57	LRRK2	0.69337859
58	MAPKAPK3	0.66447593
59	PIK3CA	0.66121626
60	TGFBR1	0.66001606
61	MAP3K12	0.65972823
62	CSF1R	0.62262524
63	OBSCN	0.60879362
64	TBK1	0.59741998
65	PIM1	0.59164656
66	MAPK13	0.58402166
67	OXSR1	0.57330820
68	AURKA	0.52555897
69	RPS6KA6	0.52476151
70	BUB1	0.52368522
71	PIK3CG	0.50811637
72	DAPK3	0.49168736
73	PRKACA	0.48585450
74	CAMK1	0.47419964
75	NEK2	0.47062494
76	DAPK1	0.44922835
77	PRKCA	0.44517273
78	JAK3	0.44018577
79	CSNK2A2	0.41212452
80	CSNK2A1	0.40441327
81	NEK1	0.40168676
82	CSK	0.38876051
83	IGF1R	0.38776011
84	CAMK2A	0.38328242
85	SIK2	0.38233663
86	TESK1	0.37676519
87	PRKCD	0.37586310
88	PRKCG	0.34730500
89	CDK8	0.34313553
90	RPS6KA4	0.33583108
91	MAP2K7	0.32532462
92	ZAP70	0.31974159
93	PRKCH	0.31871749
94	MYLK	0.30542891
95	RPS6KB2	0.28436957
96	CSNK1A1	0.26821285
97	RPS6KC1	0.25782493
98	RPS6KL1	0.25782493
99	MAP2K2	0.25291428
100	ABL1	0.25206633

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.50846258
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.71262073
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.45310507
4	Parkinsons disease_Homo sapiens_hsa05012	2.81080396
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53928651
6	Proteasome_Homo sapiens_hsa03050	2.51233581
7	Allograft rejection_Homo sapiens_hsa05330	2.16218538
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.13690589
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.09255998
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.08016734
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.03740791
12	RNA polymerase_Homo sapiens_hsa03020	2.01753793
13	Phototransduction_Homo sapiens_hsa04744	1.97112112
14	Asthma_Homo sapiens_hsa05310	1.92224373
15	Alzheimers disease_Homo sapiens_hsa05010	1.88253243
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87190145
17	Huntingtons disease_Homo sapiens_hsa05016	1.81787254
18	Sulfur relay system_Homo sapiens_hsa04122	1.80724037
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.78622298
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.77979976
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.67027216
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.66615081
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.62732457
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.62395784
25	Homologous recombination_Homo sapiens_hsa03440	1.38828142
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.37292331
27	Protein export_Homo sapiens_hsa03060	1.34141600
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31001367
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23179068
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17208419
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.13673826
32	RNA degradation_Homo sapiens_hsa03018	1.11272108
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10283846
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.09806161
35	One carbon pool by folate_Homo sapiens_hsa00670	1.06966498
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05750864
37	Caffeine metabolism_Homo sapiens_hsa00232	1.05527557
38	Olfactory transduction_Homo sapiens_hsa04740	1.01852852
39	Peroxisome_Homo sapiens_hsa04146	1.01370626
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.00502448
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.97787704
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93531112
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92277696
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91654791
45	Butanoate metabolism_Homo sapiens_hsa00650	0.91317967
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89309543
47	Retinol metabolism_Homo sapiens_hsa00830	0.88995342
48	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.87243209
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.86947100
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86818878
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85262194
52	Basal transcription factors_Homo sapiens_hsa03022	0.83159240
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82442541
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80521373
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78799625
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.77807661
57	Base excision repair_Homo sapiens_hsa03410	0.77732183
58	Purine metabolism_Homo sapiens_hsa00230	0.76638246
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74944822
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.74726615
61	Propanoate metabolism_Homo sapiens_hsa00640	0.73088522
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70728288
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69924200
64	Nicotine addiction_Homo sapiens_hsa05033	0.69595903
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68172627
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.67996836
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67837092
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64728569
69	DNA replication_Homo sapiens_hsa03030	0.62597020
70	Metabolic pathways_Homo sapiens_hsa01100	0.61328667
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60095651
72	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57010996
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54827074
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53900561
75	Mismatch repair_Homo sapiens_hsa03430	0.49149579
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45716788
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.44345135
78	Malaria_Homo sapiens_hsa05144	0.43640995
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43553191
80	Taste transduction_Homo sapiens_hsa04742	0.43168463
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42057413
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41683988
83	Viral myocarditis_Homo sapiens_hsa05416	0.41267750
84	Spliceosome_Homo sapiens_hsa03040	0.39761184
85	Morphine addiction_Homo sapiens_hsa05032	0.39401002
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39298572
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37503426
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37354732
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35875421
90	Sulfur metabolism_Homo sapiens_hsa00920	0.35664872
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.35260324
92	Regulation of autophagy_Homo sapiens_hsa04140	0.33499139
93	RNA transport_Homo sapiens_hsa03013	0.32871759
94	Measles_Homo sapiens_hsa05162	0.32716728
95	Salivary secretion_Homo sapiens_hsa04970	0.32377799
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.30398646
97	Serotonergic synapse_Homo sapiens_hsa04726	0.29766742
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.28961725
99	ABC transporters_Homo sapiens_hsa02010	0.27945835
100	Selenocompound metabolism_Homo sapiens_hsa00450	0.27846139

RPL13AP20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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