ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	7.48451877
2	cytidine catabolic process (GO:0006216)	7.48451877
3	cytidine deamination (GO:0009972)	7.48451877
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.67993344
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.48290167
6	DNA deamination (GO:0045006)	6.39060327
7	ribosomal small subunit assembly (GO:0000028)	5.57078929
8	Arp2/3 complex-mediated actin nucleation (GO:0034314)	5.06958677
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.75459298
10	actin nucleation (GO:0045010)	4.73455213
11	ATP synthesis coupled proton transport (GO:0015986)	4.72749437
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.72749437
13	regulation of chronic inflammatory response (GO:0002676)	4.47958541
14	sequestering of actin monomers (GO:0042989)	4.45442207
15	regulation of activation of Janus kinase activity (GO:0010533)	4.12833398
16	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.05261305
17	cytolysis (GO:0019835)	3.98379349
18	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.95826324
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.89475818
20	viral transcription (GO:0019083)	3.82949767
21	respiratory electron transport chain (GO:0022904)	3.73790000
22	positive regulation of B cell differentiation (GO:0045579)	3.73403654
23	electron transport chain (GO:0022900)	3.70277268
24	protein neddylation (GO:0045116)	3.67131864
25	negative T cell selection (GO:0043383)	3.66948184
26	T cell migration (GO:0072678)	3.66562212
27	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.62404614
28	positive T cell selection (GO:0043368)	3.61855346
29	translational termination (GO:0006415)	3.60673599
30	regulation of regulatory T cell differentiation (GO:0045589)	3.56533333
31	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.46368552
32	cotranslational protein targeting to membrane (GO:0006613)	3.43856124
33	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.43452948
34	protein targeting to ER (GO:0045047)	3.43070426
35	positive regulation of tolerance induction (GO:0002645)	3.42186906
36	translational elongation (GO:0006414)	3.41409266
37	regulation of T cell chemotaxis (GO:0010819)	3.41194927
38	positive regulation of T cell chemotaxis (GO:0010820)	3.41194927
39	regulation of natural killer cell mediated immunity (GO:0002715)	3.37406307
40	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.37406307
41	regulation of isotype switching to IgG isotypes (GO:0048302)	3.35791119
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.28700849
43	regulation of cellular amino acid metabolic process (GO:0006521)	3.26852451
44	pyrimidine nucleoside catabolic process (GO:0046135)	3.26607478
45	positive regulation of cell killing (GO:0031343)	3.25931682
46	maturation of SSU-rRNA (GO:0030490)	3.25859961
47	protein localization to endoplasmic reticulum (GO:0070972)	3.21894233
48	positive thymic T cell selection (GO:0045059)	3.19541016
49	proteasome assembly (GO:0043248)	3.17226576
50	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.14471431
51	regulation of T cell tolerance induction (GO:0002664)	3.14045184
52	behavioral response to nicotine (GO:0035095)	3.14000769
53	positive regulation of interleukin-8 secretion (GO:2000484)	3.12024406
54	regulation of B cell receptor signaling pathway (GO:0050855)	3.11623212
55	negative regulation of T cell apoptotic process (GO:0070233)	3.09051678
56	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.06211978
57	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.06069317
58	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.04023076
59	transmission of nerve impulse (GO:0019226)	3.03639006
60	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.02821457
61	DNA demethylation (GO:0080111)	3.00345849
62	positive regulation of calcium-mediated signaling (GO:0050850)	2.99142922
63	positive regulation of T cell apoptotic process (GO:0070234)	2.98228891
64	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.91623644
65	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.91623644
66	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.91623644
67	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.91007635
68	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.90860760
69	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.90860760
70	hydrogen ion transmembrane transport (GO:1902600)	2.90814687
71	negative regulation of viral genome replication (GO:0045071)	2.89806784
72	ribosomal small subunit biogenesis (GO:0042274)	2.89495838
73	activated T cell proliferation (GO:0050798)	2.88685519
74	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.87772818
75	regulation of cell killing (GO:0031341)	2.86015958
76	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.85518656
77	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.81863103
78	water-soluble vitamin biosynthetic process (GO:0042364)	2.79588995
79	regulation of B cell differentiation (GO:0045577)	2.78924267
80	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.78900721
81	proton transport (GO:0015992)	2.78459752
82	cellular protein complex disassembly (GO:0043624)	2.77323956
83	cellular response to interleukin-15 (GO:0071350)	2.77199964
84	regulation of T cell receptor signaling pathway (GO:0050856)	2.76929123
85	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.75593130
86	T cell receptor signaling pathway (GO:0050852)	2.75493118
87	protein complex biogenesis (GO:0070271)	2.75225800
88	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74796450
89	termination of RNA polymerase III transcription (GO:0006386)	2.74796450
90	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.74415841
91	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.74415841
92	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.73746290
93	viral life cycle (GO:0019058)	2.73316221
94	hydrogen transport (GO:0006818)	2.72164889
95	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.71882056
96	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.70487954
97	eosinophil chemotaxis (GO:0048245)	2.70392767
98	response to interferon-beta (GO:0035456)	2.70336874
99	negative regulation of oxidoreductase activity (GO:0051354)	2.70327940
100	thymic T cell selection (GO:0045061)	2.70155978

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.07796478
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.62724817
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.45029814
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.35083011
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.28893432
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.17353922
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17073749
8	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.05379041
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.95710248
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.86627463
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.86259349
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.83125882
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.83116919
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76075616
15	VDR_22108803_ChIP-Seq_LS180_Human	2.71233011
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.43241977
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.36392797
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.12694846
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10468532
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.09621801
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.09034927
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94647997
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91294494
24	MYB_26560356_Chip-Seq_TH2_Human	1.77080255
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77008381
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76158780
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72110810
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65854949
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64757784
30	RUNX_20019798_ChIP-Seq_JUKART_Human	1.62295529
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54445695
32	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.46095590
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.45994850
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.45243797
35	GATA3_26560356_Chip-Seq_TH2_Human	1.42330501
36	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40957888
37	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.40465287
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.38653566
39	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.38205049
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38020298
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37424856
42	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.36395671
43	EWS_26573619_Chip-Seq_HEK293_Human	1.34643422
44	AR_20517297_ChIP-Seq_VCAP_Human	1.33014947
45	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.31877993
46	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.31288171
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30368462
48	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.30258456
49	GATA3_27048872_Chip-Seq_THYMUS_Human	1.27909258
50	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.24236166
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.21844231
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21508666
53	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.21036337
54	HTT_18923047_ChIP-ChIP_STHdh_Human	1.20661727
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20526700
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20526700
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19836762
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19708198
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19284698
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.18080244
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.17352793
62	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16506384
63	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16308819
64	ERG_20517297_ChIP-Seq_VCAP_Human	1.14302071
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13557530
66	FUS_26573619_Chip-Seq_HEK293_Human	1.12463892
67	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12385769
68	NCOR_22424771_ChIP-Seq_293T_Human	1.12351659
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11325032
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10869322
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09190749
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08227883
73	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.07904751
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05286078
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04552858
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04552858
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04264080
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02227212
79	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.01723399
80	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.01031312
81	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.01020366
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00265864
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00228726
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.99451291
85	ERA_21632823_ChIP-Seq_H3396_Human	0.99353520
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97955437
87	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.96897424
88	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.93808725
89	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.93551365
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93186422
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92816402
92	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92348323
93	TAF15_26573619_Chip-Seq_HEK293_Human	0.91434166
94	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91293638
95	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.89922254
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89658937
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89647241
98	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.88375373
99	BCL6_27268052_Chip-Seq_Bcells_Human	0.88332673
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87737140

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.28815532
2	MP0009785_altered_susceptibility_to	3.17027184
3	MP0002102_abnormal_ear_morphology	3.05729691
4	MP0001835_abnormal_antigen_presentation	2.72646171
5	MP0009333_abnormal_splenocyte_physiolog	2.60177925
6	MP0001873_stomach_inflammation	2.40480520
7	MP0002166_altered_tumor_susceptibility	2.40102880
8	MP0009379_abnormal_foot_pigmentation	2.33491918
9	MP0003763_abnormal_thymus_physiology	2.31524794
10	MP0005645_abnormal_hypothalamus_physiol	2.19541998
11	MP0000685_abnormal_immune_system	2.06572393
12	MP0002006_tumorigenesis	2.03149867
13	MP0003878_abnormal_ear_physiology	1.92334718
14	MP0005377_hearing/vestibular/ear_phenot	1.92334718
15	MP0001800_abnormal_humoral_immune	1.88415780
16	MP0005000_abnormal_immune_tolerance	1.85914525
17	MP0006072_abnormal_retinal_apoptosis	1.85133450
18	MP0008872_abnormal_physiological_respon	1.83554218
19	MP0005387_immune_system_phenotype	1.79483386
20	MP0001790_abnormal_immune_system	1.79483386
21	MP0006082_CNS_inflammation	1.77105176
22	MP0005025_abnormal_response_to	1.76331074
23	MP0002148_abnormal_hypersensitivity_rea	1.74158400
24	MP0005084_abnormal_gallbladder_morpholo	1.72718897
25	MP0008875_abnormal_xenobiotic_pharmacok	1.71238772
26	MP0005551_abnormal_eye_electrophysiolog	1.70580016
27	MP0004147_increased_porphyrin_level	1.70129713
28	MP0002723_abnormal_immune_serum	1.66557534
29	MP0002420_abnormal_adaptive_immunity	1.66089236
30	MP0004142_abnormal_muscle_tone	1.65774486
31	MP0002837_dystrophic_cardiac_calcinosis	1.63112985
32	MP0001905_abnormal_dopamine_level	1.60926942
33	MP0001819_abnormal_immune_cell	1.59434966
34	MP0001919_abnormal_reproductive_system	1.55244222
35	MP0006292_abnormal_olfactory_placode	1.55070328
36	MP0003866_abnormal_defecation	1.53740813
37	MP0001485_abnormal_pinna_reflex	1.53402449
38	MP0002876_abnormal_thyroid_physiology	1.50385281
39	MP0002277_abnormal_respiratory_mucosa	1.49404327
40	MP0004145_abnormal_muscle_electrophysio	1.48058347
41	MP0008877_abnormal_DNA_methylation	1.46410282
42	MP0003646_muscle_fatigue	1.46121768
43	MP0003567_abnormal_fetal_cardiomyocyte	1.42784364
44	MP0005389_reproductive_system_phenotype	1.41993386
45	MP0005646_abnormal_pituitary_gland	1.39405416
46	MP0002138_abnormal_hepatobiliary_system	1.35107814
47	MP0003786_premature_aging	1.31787901
48	MP0001984_abnormal_olfaction	1.30202120
49	MP0003787_abnormal_imprinting	1.28599225
50	MP0004742_abnormal_vestibular_system	1.27662217
51	MP0000716_abnormal_immune_system	1.26519667
52	MP0002163_abnormal_gland_morphology	1.25858348
53	MP0002452_abnormal_antigen_presenting	1.25692586
54	MP0001986_abnormal_taste_sensitivity	1.25021361
55	MP0002653_abnormal_ependyma_morphology	1.23059656
56	MP0006276_abnormal_autonomic_nervous	1.21501159
57	MP0002405_respiratory_system_inflammati	1.20472900
58	MP0002398_abnormal_bone_marrow	1.18041219
59	MP0000372_irregular_coat_pigmentation	1.15577659
60	MP0005075_abnormal_melanosome_morpholog	1.10861825
61	MP0002272_abnormal_nervous_system	1.10310783
62	MP0002234_abnormal_pharynx_morphology	1.06680008
63	MP0005410_abnormal_fertilization	1.06426439
64	MP0003436_decreased_susceptibility_to	1.05808841
65	MP0001968_abnormal_touch/_nociception	1.05057240
66	MP0001845_abnormal_inflammatory_respons	1.04881725
67	MP0002736_abnormal_nociception_after	1.03786859
68	MP0000703_abnormal_thymus_morphology	1.02635696
69	MP0001501_abnormal_sleep_pattern	0.99760293
70	MP0000689_abnormal_spleen_morphology	0.98286921
71	MP0005253_abnormal_eye_physiology	0.98211209
72	MP0009745_abnormal_behavioral_response	0.93146110
73	MP0002429_abnormal_blood_cell	0.92478844
74	MP0003045_fibrosis	0.92058244
75	MP0002733_abnormal_thermal_nociception	0.90364746
76	MP0010155_abnormal_intestine_physiology	0.88856036
77	MP0009764_decreased_sensitivity_to	0.88516480
78	MP0008469_abnormal_protein_level	0.88290018
79	MP0001542_abnormal_bone_strength	0.88124885
80	MP0002722_abnormal_immune_system	0.87680756
81	MP0003195_calcinosis	0.86795393
82	MP0002160_abnormal_reproductive_system	0.86601246
83	MP0003448_altered_tumor_morphology	0.85712869
84	MP0003011_delayed_dark_adaptation	0.85136605
85	MP0006036_abnormal_mitochondrial_physio	0.84855857
86	MP0001970_abnormal_pain_threshold	0.83826979
87	MP0003880_abnormal_central_pattern	0.83255445
88	MP0002693_abnormal_pancreas_physiology	0.82314432
89	MP0005379_endocrine/exocrine_gland_phen	0.80649519
90	MP0001348_abnormal_lacrimal_gland	0.79894265
91	MP0005166_decreased_susceptibility_to	0.78624090
92	MP0002638_abnormal_pupillary_reflex	0.77937942
93	MP0008995_early_reproductive_senescence	0.77611594
94	MP0004885_abnormal_endolymph	0.76447661
95	MP0001963_abnormal_hearing_physiology	0.76002897
96	MP0009763_increased_sensitivity_to	0.73374402
97	MP0000026_abnormal_inner_ear	0.71488452
98	MP0001663_abnormal_digestive_system	0.70202512
99	MP0002419_abnormal_innate_immunity	0.69819430
100	MP0009643_abnormal_urine_homeostasis	0.69031295

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.63091998
2	Hypoproteinemia (HP:0003075)	4.36223430
3	T lymphocytopenia (HP:0005403)	4.07126068
4	Acute necrotizing encephalopathy (HP:0006965)	4.03518808
5	Mitochondrial inheritance (HP:0001427)	3.99891865
6	Increased hepatocellular lipid droplets (HP:0006565)	3.84350602
7	Abnormality of T cell number (HP:0011839)	3.78510074
8	Renal Fanconi syndrome (HP:0001994)	3.74189460
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.66913043
10	IgG deficiency (HP:0004315)	3.59413161
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.50004275
12	Hepatocellular necrosis (HP:0001404)	3.47095262
13	Increased CSF lactate (HP:0002490)	3.46858278
14	Lipid accumulation in hepatocytes (HP:0006561)	3.44730047
15	Progressive macrocephaly (HP:0004481)	3.36717043
16	Severe combined immunodeficiency (HP:0004430)	3.33762878
17	Acute encephalopathy (HP:0006846)	3.33198409
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.17693129
19	Increased intramyocellular lipid droplets (HP:0012240)	3.10854833
20	Increased IgM level (HP:0003496)	3.02421924
21	Hepatic necrosis (HP:0002605)	3.00605180
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.98838448
23	Reticulocytopenia (HP:0001896)	2.98555163
24	Pancreatic cysts (HP:0001737)	2.96361573
25	3-Methylglutaconic aciduria (HP:0003535)	2.90378621
26	Exertional dyspnea (HP:0002875)	2.83430891
27	Thyroiditis (HP:0100646)	2.78119166
28	Autoimmune hemolytic anemia (HP:0001890)	2.73458024
29	Optic disc pallor (HP:0000543)	2.71925325
30	Abnormality of midbrain morphology (HP:0002418)	2.71523345
31	Molar tooth sign on MRI (HP:0002419)	2.71523345
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.69917948
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.66717173
34	Abolished electroretinogram (ERG) (HP:0000550)	2.65934508
35	Abnormality of B cell number (HP:0010975)	2.65810987
36	B lymphocytopenia (HP:0010976)	2.65783261
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.61109844
38	Abnormal albumin level (HP:0012116)	2.59583892
39	Hypoalbuminemia (HP:0003073)	2.59583892
40	Congenital stationary night blindness (HP:0007642)	2.59544838
41	Cerebral edema (HP:0002181)	2.59535334
42	Abnormality of T cells (HP:0002843)	2.59300811
43	Increased muscle lipid content (HP:0009058)	2.55439432
44	Combined immunodeficiency (HP:0005387)	2.52211823
45	Abnormal drinking behavior (HP:0030082)	2.48651888
46	Polydipsia (HP:0001959)	2.48651888
47	Tubular atrophy (HP:0000092)	2.46413631
48	Pancreatic fibrosis (HP:0100732)	2.46157836
49	Abnormal number of erythroid precursors (HP:0012131)	2.43155781
50	Attenuation of retinal blood vessels (HP:0007843)	2.43126664
51	Nephronophthisis (HP:0000090)	2.42283920
52	Pancytopenia (HP:0001876)	2.40028568
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.39502177
54	Decreased central vision (HP:0007663)	2.36077767
55	Increased serum lactate (HP:0002151)	2.35914964
56	True hermaphroditism (HP:0010459)	2.35136155
57	Generalized aminoaciduria (HP:0002909)	2.33829625
58	Constricted visual fields (HP:0001133)	2.33347011
59	Abnormality of renal resorption (HP:0011038)	2.31630610
60	Encephalitis (HP:0002383)	2.31146761
61	Medial flaring of the eyebrow (HP:0010747)	2.28744154
62	Abnormality of the prostate (HP:0008775)	2.25457497
63	Abnormality of eosinophils (HP:0001879)	2.23235556
64	Abnormality of the renal cortex (HP:0011035)	2.22596670
65	Chronic diarrhea (HP:0002028)	2.19370267
66	Stomatitis (HP:0010280)	2.17383605
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.14596511
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.14596511
69	Glycosuria (HP:0003076)	2.11970765
70	Abnormality of urine glucose concentration (HP:0011016)	2.11970765
71	Macrocytic anemia (HP:0001972)	2.10782473
72	Lactic acidosis (HP:0003128)	2.08450433
73	Pendular nystagmus (HP:0012043)	2.02525654
74	Absent thumb (HP:0009777)	2.02007849
75	Abnormality of the renal medulla (HP:0100957)	1.97377634
76	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.93809503
77	Hyperphosphaturia (HP:0003109)	1.93456335
78	Exercise intolerance (HP:0003546)	1.92359409
79	Dyschromatopsia (HP:0007641)	1.91435584
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.90122312
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.90122312
82	Ketosis (HP:0001946)	1.89624389
83	Asplenia (HP:0001746)	1.89327526
84	Lethargy (HP:0001254)	1.88709017
85	Polyuria (HP:0000103)	1.87024874
86	Respiratory failure (HP:0002878)	1.87011212
87	Leukodystrophy (HP:0002415)	1.84249056
88	Ketoacidosis (HP:0001993)	1.82217212
89	Stenosis of the external auditory canal (HP:0000402)	1.80465288
90	Reduced antithrombin III activity (HP:0001976)	1.79122957
91	Chronic sinusitis (HP:0011109)	1.78788438
92	Respiratory difficulties (HP:0002880)	1.76642946
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75621008
94	Myokymia (HP:0002411)	1.74581642
95	Hypoplasia of the ulna (HP:0003022)	1.73881004
96	Abnormality of DNA repair (HP:0003254)	1.69968019
97	Hypoplasia of the uterus (HP:0000013)	1.69765757
98	Pulmonary infiltrates (HP:0002113)	1.69403996
99	Abnormality of macular pigmentation (HP:0008002)	1.69327318
100	Pigmentary retinal degeneration (HP:0001146)	1.69246849

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.03284177
2	KDR	4.40374840
3	TESK2	3.23416317
4	MAP4K1	3.11008474
5	ZAK	3.08417964
6	TIE1	2.84619003
7	TLK1	2.66453684
8	VRK2	2.61804076
9	BCKDK	2.60156922
10	MAP4K2	2.36157994
11	TAOK3	2.14644812
12	WNK4	2.12810367
13	GRK1	2.09473471
14	MAP3K11	2.00060069
15	TESK1	1.94049082
16	ADRBK2	1.93574954
17	VRK1	1.84980044
18	TEC	1.81901363
19	ITK	1.72488735
20	MAP3K12	1.65579868
21	MST4	1.62562879
22	NUAK1	1.57631122
23	LIMK1	1.41844320
24	FRK	1.36967419
25	FES	1.35667362
26	GRK6	1.32289185
27	PINK1	1.32009522
28	PASK	1.31166552
29	SCYL2	1.28755044
30	PIK3CG	1.22879014
31	DAPK2	1.22277695
32	MAP2K6	1.15041261
33	NME1	1.14452732
34	BTK	1.01869891
35	PRKCQ	0.99804015
36	STK39	0.99727001
37	SYK	0.98888130
38	WNK3	0.95518157
39	DAPK1	0.94235354
40	LCK	0.90140921
41	BMPR1B	0.89901147
42	DYRK2	0.86357883
43	CDK19	0.83667067
44	CSNK1G3	0.80156695
45	ZAP70	0.79551027
46	TNK2	0.78171295
47	CAMKK2	0.77930298
48	INSRR	0.76579336
49	GRK7	0.74507127
50	MAP3K4	0.72661229
51	MUSK	0.72525061
52	MAP2K7	0.72175506
53	MAPKAPK3	0.71034063
54	IKBKB	0.70176398
55	CSK	0.70065142
56	BCR	0.69656197
57	RPS6KA5	0.69523181
58	RPS6KA4	0.69032759
59	ADRBK1	0.68540078
60	PIM1	0.66004088
61	OXSR1	0.63791751
62	LYN	0.63770291
63	SRPK1	0.62466558
64	MATK	0.61615449
65	CSNK1G1	0.61042320
66	STK16	0.59854901
67	DAPK3	0.56353302
68	TRIM28	0.55194041
69	MAPK13	0.54845908
70	MYLK	0.54062845
71	CSNK1G2	0.52920058
72	PIK3CA	0.52546808
73	CSNK1A1L	0.50409422
74	OBSCN	0.48081907
75	FYN	0.45141100
76	IGF1R	0.44439050
77	CSF1R	0.42816522
78	MINK1	0.41576312
79	PRKCG	0.40977084
80	LRRK2	0.40169343
81	PRKACA	0.39548252
82	NLK	0.38285421
83	PRKCA	0.37749245
84	IKBKE	0.37491015
85	KIT	0.37411548
86	PRKCH	0.37136009
87	CSNK2A2	0.35564549
88	TAF1	0.34978767
89	CAMK2A	0.34211915
90	CSNK2A1	0.32170534
91	PLK3	0.31728472
92	CAMKK1	0.30895019
93	MAP3K5	0.29435064
94	ROCK1	0.28572005
95	TAOK2	0.27810364
96	PIM2	0.26997124
97	AURKA	0.26063280
98	GRK5	0.25786292
99	TNIK	0.25235802
100	PRKCD	0.24605787

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.39088743
2	Proteasome_Homo sapiens_hsa03050	4.24226184
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.04706084
4	Ribosome_Homo sapiens_hsa03010	3.98963553
5	Parkinsons disease_Homo sapiens_hsa05012	3.31246164
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.51276874
7	RNA polymerase_Homo sapiens_hsa03020	2.44337911
8	Allograft rejection_Homo sapiens_hsa05330	2.37894455
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.29463079
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.17398528
11	Alzheimers disease_Homo sapiens_hsa05010	2.16505972
12	Huntingtons disease_Homo sapiens_hsa05016	2.13571144
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.08951188
14	Phototransduction_Homo sapiens_hsa04744	2.05231926
15	Antigen processing and presentation_Homo sapiens_hsa04612	2.03540655
16	Protein export_Homo sapiens_hsa03060	2.02281304
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.01141724
18	Cardiac muscle contraction_Homo sapiens_hsa04260	2.00994691
19	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.83417313
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.82746430
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.82039144
22	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.56338333
23	Asthma_Homo sapiens_hsa05310	1.45704852
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43016900
25	Homologous recombination_Homo sapiens_hsa03440	1.29951162
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24876201
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24856554
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.21260284
29	Basal transcription factors_Homo sapiens_hsa03022	1.15944576
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08715706
31	Peroxisome_Homo sapiens_hsa04146	1.07338739
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.04485814
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.00901068
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99524892
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98738258
36	Purine metabolism_Homo sapiens_hsa00230	0.98055414
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95720568
38	Rheumatoid arthritis_Homo sapiens_hsa05323	0.93901202
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92590466
40	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.91316245
41	RNA degradation_Homo sapiens_hsa03018	0.91269075
42	Propanoate metabolism_Homo sapiens_hsa00640	0.88630975
43	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88546596
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.88360779
45	Measles_Homo sapiens_hsa05162	0.83973654
46	Butanoate metabolism_Homo sapiens_hsa00650	0.80469767
47	Mismatch repair_Homo sapiens_hsa03430	0.77079479
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76823672
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76620945
50	Sulfur metabolism_Homo sapiens_hsa00920	0.71986123
51	Nicotine addiction_Homo sapiens_hsa05033	0.71370057
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69538547
53	One carbon pool by folate_Homo sapiens_hsa00670	0.68527669
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.67198438
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67102330
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66899624
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66339266
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65886379
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64863761
60	Olfactory transduction_Homo sapiens_hsa04740	0.64443598
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.60064521
62	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58626068
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58175728
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56979218
65	Retinol metabolism_Homo sapiens_hsa00830	0.54210615
66	Shigellosis_Homo sapiens_hsa05131	0.53394200
67	Malaria_Homo sapiens_hsa05144	0.52653893
68	Metabolic pathways_Homo sapiens_hsa01100	0.52415103
69	Regulation of autophagy_Homo sapiens_hsa04140	0.51373318
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50955125
71	Caffeine metabolism_Homo sapiens_hsa00232	0.49232125
72	Base excision repair_Homo sapiens_hsa03410	0.48257470
73	DNA replication_Homo sapiens_hsa03030	0.46836386
74	Taste transduction_Homo sapiens_hsa04742	0.46763646
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46445860
76	Spliceosome_Homo sapiens_hsa03040	0.46201151
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.42750199
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.41616883
79	Viral myocarditis_Homo sapiens_hsa05416	0.40958711
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40786559
81	Salmonella infection_Homo sapiens_hsa05132	0.37701672
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35714103
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34546816
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.34320961
85	RNA transport_Homo sapiens_hsa03013	0.33018567
86	Fatty acid elongation_Homo sapiens_hsa00062	0.32814786
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31636147
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.30581944
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29257539
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26677597
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26418580
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.24071529
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.23847146
94	Morphine addiction_Homo sapiens_hsa05032	0.23562387
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23070931
96	Salivary secretion_Homo sapiens_hsa04970	0.22943495
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.18597563
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.17873392
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.17430588
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.17243103

RPL13AP23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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