ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.96977213
2	DNA deamination (GO:0045006)	6.82490001
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.43215574
4	cytidine deamination (GO:0009972)	6.35581127
5	cytidine metabolic process (GO:0046087)	6.35581127
6	cytidine catabolic process (GO:0006216)	6.35581127
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.54559634
8	viral transcription (GO:0019083)	5.37625204
9	translational termination (GO:0006415)	5.17897733
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.71071700
11	ATP synthesis coupled proton transport (GO:0015986)	4.71071700
12	translational elongation (GO:0006414)	4.68408103
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.58750082
14	maturation of SSU-rRNA (GO:0030490)	4.52246312
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.51476787
16	ribosomal small subunit biogenesis (GO:0042274)	4.49863705
17	protein targeting to ER (GO:0045047)	4.45213452
18	cotranslational protein targeting to membrane (GO:0006613)	4.43827773
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.24090100
20	protein localization to endoplasmic reticulum (GO:0070972)	4.23096653
21	cellular protein complex disassembly (GO:0043624)	3.88817419
22	protein neddylation (GO:0045116)	3.88363292
23	viral life cycle (GO:0019058)	3.81940055
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.68545908
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.64232678
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53195218
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53195218
28	respiratory electron transport chain (GO:0022904)	3.50297742
29	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.48684307
30	translational initiation (GO:0006413)	3.47505816
31	electron transport chain (GO:0022900)	3.47157157
32	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.42770386
33	behavioral response to nicotine (GO:0035095)	3.42169847
34	regulation of regulatory T cell differentiation (GO:0045589)	3.39684929
35	negative regulation of T cell apoptotic process (GO:0070233)	3.39262981
36	ribosomal large subunit biogenesis (GO:0042273)	3.34665401
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.33574561
38	negative regulation by host of viral transcription (GO:0043922)	3.33017865
39	metallo-sulfur cluster assembly (GO:0031163)	3.30736112
40	iron-sulfur cluster assembly (GO:0016226)	3.30736112
41	protein complex biogenesis (GO:0070271)	3.24688319
42	translation (GO:0006412)	3.23393547
43	positive T cell selection (GO:0043368)	3.23149503
44	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.20860181
45	positive thymic T cell selection (GO:0045059)	3.20429620
46	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.19139233
47	protein complex disassembly (GO:0043241)	3.13191427
48	T cell migration (GO:0072678)	3.10955074
49	termination of RNA polymerase III transcription (GO:0006386)	3.10832220
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.10832220
51	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.10272764
52	proteasome assembly (GO:0043248)	3.08109260
53	pyrimidine nucleoside catabolic process (GO:0046135)	3.07506994
54	sequestering of actin monomers (GO:0042989)	3.07130494
55	actin nucleation (GO:0045010)	3.04940650
56	positive regulation of calcium-mediated signaling (GO:0050850)	3.02056078
57	chaperone-mediated protein transport (GO:0072321)	2.97783801
58	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.96996363
59	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.96212949
60	macromolecular complex disassembly (GO:0032984)	2.96104764
61	regulation of activation of Janus kinase activity (GO:0010533)	2.96097578
62	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.95409837
63	regulation of natural killer cell mediated immunity (GO:0002715)	2.95409837
64	negative regulation of mast cell activation (GO:0033004)	2.95328187
65	cytolysis (GO:0019835)	2.94228471
66	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.93421691
67	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.93421691
68	NADH dehydrogenase complex assembly (GO:0010257)	2.93421691
69	negative T cell selection (GO:0043383)	2.91005233
70	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.90217158
71	protein targeting to membrane (GO:0006612)	2.88720606
72	positive regulation of cell killing (GO:0031343)	2.86338481
73	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83310014
74	regulation of chronic inflammatory response (GO:0002676)	2.82128982
75	platelet dense granule organization (GO:0060155)	2.80356272
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.78740530
77	regulation of B cell receptor signaling pathway (GO:0050855)	2.77921525
78	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.76503283
79	regulation of isotype switching to IgG isotypes (GO:0048302)	2.74841207
80	ATP biosynthetic process (GO:0006754)	2.74649219
81	positive regulation of defense response to virus by host (GO:0002230)	2.73799608
82	hydrogen ion transmembrane transport (GO:1902600)	2.73339313
83	piRNA metabolic process (GO:0034587)	2.71324076
84	response to interferon-beta (GO:0035456)	2.71273965
85	positive regulation of T cell apoptotic process (GO:0070234)	2.71175511
86	regulation of T cell receptor signaling pathway (GO:0050856)	2.68347267
87	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67963006
88	regulation of T cell mediated cytotoxicity (GO:0001914)	2.67466908
89	cellular component biogenesis (GO:0044085)	2.66319786
90	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.64533534
91	ribonucleoprotein complex biogenesis (GO:0022613)	2.64474115
92	regulation of cell killing (GO:0031341)	2.64416397
93	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.64396290
94	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.62524756
95	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.62377507
96	proton transport (GO:0015992)	2.58801204
97	negative regulation of telomere maintenance (GO:0032205)	2.58557902
98	cellular response to interleukin-15 (GO:0071350)	2.58443455
99	regulation of T cell apoptotic process (GO:0070232)	2.55947917
100	response to pheromone (GO:0019236)	2.55107775

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.62538579
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.62328640
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.60156450
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.22747843
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.04962960
6	VDR_22108803_ChIP-Seq_LS180_Human	3.03529407
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.91504065
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89877243
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.88426136
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.81937372
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68045300
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.62253935
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.57399345
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.50292241
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.42274354
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.35844116
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.28343980
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26568564
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.15841624
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01356773
21	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.86459305
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78778245
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.78207021
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71703805
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.67960911
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65541784
27	MYB_26560356_Chip-Seq_TH2_Human	1.60767389
28	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.54880123
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49999356
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49496269
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.49218787
32	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.46284818
33	NANOG_20526341_ChIP-Seq_ESCs_Human	1.44149182
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.43996332
35	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.43742140
36	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.42424166
37	RUNX_20019798_ChIP-Seq_JUKART_Human	1.41123692
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38601147
39	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.36110637
40	GATA3_26560356_Chip-Seq_TH2_Human	1.35921574
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.33005001
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29694440
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29300118
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28654711
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28654711
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28496494
47	NCOR_22424771_ChIP-Seq_293T_Human	1.27215549
48	AR_20517297_ChIP-Seq_VCAP_Human	1.26730927
49	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.24838109
50	GATA3_27048872_Chip-Seq_THYMUS_Human	1.24617572
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24450204
52	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24406668
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24215111
54	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.23386456
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21563522
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20690132
57	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.18600152
58	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18151054
59	ERA_21632823_ChIP-Seq_H3396_Human	1.17139707
60	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16957821
61	BCL6_27268052_Chip-Seq_Bcells_Human	1.16606668
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14434541
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14241208
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12458526
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11487753
66	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10801019
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09714405
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.09390266
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09211399
70	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09111952
71	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08697970
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08386258
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07438314
74	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07271642
75	CTCF_20526341_ChIP-Seq_ESCs_Human	1.06274696
76	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.05943762
77	ER_23166858_ChIP-Seq_MCF-7_Human	1.05577228
78	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04116881
79	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03098862
80	EWS_26573619_Chip-Seq_HEK293_Human	1.01631821
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01268690
82	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00905362
83	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98085572
84	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97651857
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96588992
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96172263
87	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96172263
88	TTF2_22483619_ChIP-Seq_HELA_Human	0.95917772
89	P300_27268052_Chip-Seq_Bcells_Human	0.95856227
90	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93838555
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.93660831
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93424229
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92522999
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.92522999
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.91636854
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91017449
97	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90621148
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.90299924
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89951674
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89662311

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.68617880
2	MP0009379_abnormal_foot_pigmentation	4.66716717
3	MP0006292_abnormal_olfactory_placode	3.41401732
4	MP0003646_muscle_fatigue	2.40953796
5	MP0009785_altered_susceptibility_to	2.40297621
6	MP0001835_abnormal_antigen_presentation	2.34155083
7	MP0002102_abnormal_ear_morphology	2.21327343
8	MP0004147_increased_porphyrin_level	2.13119327
9	MP0003763_abnormal_thymus_physiology	2.11819420
10	MP0009333_abnormal_splenocyte_physiolog	1.96576278
11	MP0005645_abnormal_hypothalamus_physiol	1.94085426
12	MP0005377_hearing/vestibular/ear_phenot	1.91387133
13	MP0003878_abnormal_ear_physiology	1.91387133
14	MP0008877_abnormal_DNA_methylation	1.88138320
15	MP0008872_abnormal_physiological_respon	1.87170861
16	MP0006072_abnormal_retinal_apoptosis	1.86807900
17	MP0002163_abnormal_gland_morphology	1.85066029
18	MP0005000_abnormal_immune_tolerance	1.80456937
19	MP0002148_abnormal_hypersensitivity_rea	1.79760764
20	MP0001800_abnormal_humoral_immune	1.73884151
21	MP0001873_stomach_inflammation	1.72775146
22	MP0000372_irregular_coat_pigmentation	1.66636795
23	MP0000685_abnormal_immune_system	1.65969192
24	MP0002420_abnormal_adaptive_immunity	1.59288967
25	MP0001919_abnormal_reproductive_system	1.58500134
26	MP0001790_abnormal_immune_system	1.56722562
27	MP0005387_immune_system_phenotype	1.56722562
28	MP0002723_abnormal_immune_serum	1.55966786
29	MP0008875_abnormal_xenobiotic_pharmacok	1.55845280
30	MP0005551_abnormal_eye_electrophysiolog	1.55661593
31	MP0001819_abnormal_immune_cell	1.53246866
32	MP0005389_reproductive_system_phenotype	1.49294654
33	MP0004885_abnormal_endolymph	1.47464747
34	MP0005025_abnormal_response_to	1.45742902
35	MP0004145_abnormal_muscle_electrophysio	1.45474254
36	MP0001485_abnormal_pinna_reflex	1.39954169
37	MP0005646_abnormal_pituitary_gland	1.39155163
38	MP0005075_abnormal_melanosome_morpholog	1.39146072
39	MP0003011_delayed_dark_adaptation	1.38246765
40	MP0001968_abnormal_touch/_nociception	1.36160626
41	MP0001905_abnormal_dopamine_level	1.31844460
42	MP0003866_abnormal_defecation	1.30772485
43	MP0006082_CNS_inflammation	1.30749166
44	MP0001986_abnormal_taste_sensitivity	1.30657766
45	MP0002166_altered_tumor_susceptibility	1.29665888
46	MP0002138_abnormal_hepatobiliary_system	1.23559343
47	MP0000716_abnormal_immune_system	1.21708176
48	MP0005410_abnormal_fertilization	1.21389585
49	MP0002452_abnormal_antigen_presenting	1.20767025
50	MP0002405_respiratory_system_inflammati	1.20211803
51	MP0002653_abnormal_ependyma_morphology	1.20203940
52	MP0002837_dystrophic_cardiac_calcinosis	1.19612045
53	MP0005084_abnormal_gallbladder_morpholo	1.19194065
54	MP0002736_abnormal_nociception_after	1.18606633
55	MP0002006_tumorigenesis	1.18078322
56	MP0004142_abnormal_muscle_tone	1.16555153
57	MP0002398_abnormal_bone_marrow	1.15844379
58	MP0002160_abnormal_reproductive_system	1.15439020
59	MP0008058_abnormal_DNA_repair	1.13446988
60	MP0002277_abnormal_respiratory_mucosa	1.13442638
61	MP0005379_endocrine/exocrine_gland_phen	1.13438244
62	MP0002095_abnormal_skin_pigmentation	1.13312741
63	MP0004742_abnormal_vestibular_system	1.11377716
64	MP0002876_abnormal_thyroid_physiology	1.10405441
65	MP0003787_abnormal_imprinting	1.09350289
66	MP0000703_abnormal_thymus_morphology	1.08393594
67	MP0002638_abnormal_pupillary_reflex	1.07228054
68	MP0003195_calcinosis	1.02533303
69	MP0008789_abnormal_olfactory_epithelium	1.01656145
70	MP0006276_abnormal_autonomic_nervous	1.01081463
71	MP0005253_abnormal_eye_physiology	1.00927791
72	MP0002234_abnormal_pharynx_morphology	1.00460247
73	MP0000689_abnormal_spleen_morphology	1.00425878
74	MP0003786_premature_aging	0.98220499
75	MP0010155_abnormal_intestine_physiology	0.98205069
76	MP0001845_abnormal_inflammatory_respons	0.98056726
77	MP0002933_joint_inflammation	0.96453294
78	MP0002722_abnormal_immune_system	0.94459994
79	MP0002429_abnormal_blood_cell	0.90380226
80	MP0005174_abnormal_tail_pigmentation	0.87404359
81	MP0008995_early_reproductive_senescence	0.87223590
82	MP0000631_abnormal_neuroendocrine_gland	0.86768878
83	MP0009764_decreased_sensitivity_to	0.86631078
84	MP0001984_abnormal_olfaction	0.86043315
85	MP0000049_abnormal_middle_ear	0.85487106
86	MP0002272_abnormal_nervous_system	0.81052143
87	MP0008469_abnormal_protein_level	0.80339982
88	MP0001963_abnormal_hearing_physiology	0.80156552
89	MP0001764_abnormal_homeostasis	0.77185114
90	MP0001293_anophthalmia	0.76708519
91	MP0002693_abnormal_pancreas_physiology	0.75868819
92	MP0009745_abnormal_behavioral_response	0.75398052
93	MP0001119_abnormal_female_reproductive	0.75093046
94	MP0001188_hyperpigmentation	0.75026283
95	MP0001501_abnormal_sleep_pattern	0.74113373
96	MP0002938_white_spotting	0.71410375
97	MP0002210_abnormal_sex_determination	0.71243227
98	MP0002733_abnormal_thermal_nociception	0.70999944
99	MP0002822_catalepsy	0.69472150
100	MP0002419_abnormal_innate_immunity	0.69455021

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.56829636
2	Aplastic anemia (HP:0001915)	4.54067530
3	IgG deficiency (HP:0004315)	3.84958425
4	Mitochondrial inheritance (HP:0001427)	3.82277402
5	Acute necrotizing encephalopathy (HP:0006965)	3.79381031
6	Abnormal rod and cone electroretinograms (HP:0008323)	3.52949610
7	Increased hepatocellular lipid droplets (HP:0006565)	3.48914316
8	Congenital stationary night blindness (HP:0007642)	3.46851316
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.46220855
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.43804289
11	T lymphocytopenia (HP:0005403)	3.32859622
12	Severe combined immunodeficiency (HP:0004430)	3.30671165
13	Increased CSF lactate (HP:0002490)	3.30300808
14	Hypoproteinemia (HP:0003075)	3.28584990
15	Acute encephalopathy (HP:0006846)	3.20490019
16	Abnormality of T cell number (HP:0011839)	3.19117154
17	Lipid accumulation in hepatocytes (HP:0006561)	3.19056540
18	Hepatocellular necrosis (HP:0001404)	3.14186522
19	Increased intramyocellular lipid droplets (HP:0012240)	3.13185718
20	Reticulocytopenia (HP:0001896)	3.10366029
21	Renal Fanconi syndrome (HP:0001994)	3.09075844
22	Progressive macrocephaly (HP:0004481)	3.05436036
23	Pancreatic cysts (HP:0001737)	3.05193572
24	Abnormal number of erythroid precursors (HP:0012131)	3.04549762
25	3-Methylglutaconic aciduria (HP:0003535)	3.03444070
26	Increased IgM level (HP:0003496)	2.94194006
27	Attenuation of retinal blood vessels (HP:0007843)	2.93340749
28	Abnormality of midbrain morphology (HP:0002418)	2.82800489
29	Molar tooth sign on MRI (HP:0002419)	2.82800489
30	Pancreatic fibrosis (HP:0100732)	2.80725606
31	Elevated erythrocyte sedimentation rate (HP:0003565)	2.79549811
32	Abolished electroretinogram (ERG) (HP:0000550)	2.72892759
33	Macrocytic anemia (HP:0001972)	2.71952926
34	Abnormality of B cell number (HP:0010975)	2.71744570
35	Abnormality of T cells (HP:0002843)	2.69834107
36	Thyroiditis (HP:0100646)	2.62510388
37	Increased muscle lipid content (HP:0009058)	2.61885398
38	Cerebral edema (HP:0002181)	2.61323425
39	Hepatic necrosis (HP:0002605)	2.59517470
40	Optic disc pallor (HP:0000543)	2.56144625
41	True hermaphroditism (HP:0010459)	2.54167140
42	Decreased central vision (HP:0007663)	2.53744287
43	Autoimmune hemolytic anemia (HP:0001890)	2.50766991
44	Combined immunodeficiency (HP:0005387)	2.50126000
45	Panhypogammaglobulinemia (HP:0003139)	2.48825352
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.39859441
47	B lymphocytopenia (HP:0010976)	2.36778407
48	Absent thumb (HP:0009777)	2.36251412
49	Pancytopenia (HP:0001876)	2.35346226
50	Exertional dyspnea (HP:0002875)	2.34778775
51	Constricted visual fields (HP:0001133)	2.34382836
52	Stenosis of the external auditory canal (HP:0000402)	2.33290220
53	Increased serum lactate (HP:0002151)	2.29536260
54	Stomatitis (HP:0010280)	2.28106244
55	Abnormality of eosinophils (HP:0001879)	2.26086298
56	Pallor (HP:0000980)	2.25366285
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.23209093
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.22728413
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.22728413
60	Encephalitis (HP:0002383)	2.16008254
61	Asplenia (HP:0001746)	2.15217690
62	Lactic acidosis (HP:0003128)	2.14340671
63	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.13908676
64	Colon cancer (HP:0003003)	2.10911480
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10648639
66	Pendular nystagmus (HP:0012043)	2.10173515
67	Abnormality of the prostate (HP:0008775)	2.06745890
68	Nephronophthisis (HP:0000090)	2.05262201
69	Septo-optic dysplasia (HP:0100842)	2.02140231
70	Lethargy (HP:0001254)	2.02127148
71	Type II lissencephaly (HP:0007260)	2.00484557
72	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.00094332
73	Abnormality of renal resorption (HP:0011038)	1.96912165
74	Polydipsia (HP:0001959)	1.96385461
75	Abnormal drinking behavior (HP:0030082)	1.96385461
76	Hyperglycinemia (HP:0002154)	1.95866917
77	Polyuria (HP:0000103)	1.95673668
78	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.94310121
79	Abnormality of the renal cortex (HP:0011035)	1.92227640
80	Methylmalonic acidemia (HP:0002912)	1.85884453
81	Agammaglobulinemia (HP:0004432)	1.81561225
82	Medial flaring of the eyebrow (HP:0010747)	1.81438076
83	Abnormal albumin level (HP:0012116)	1.78755448
84	Hypoalbuminemia (HP:0003073)	1.78755448
85	Respiratory failure (HP:0002878)	1.77496785
86	Sclerocornea (HP:0000647)	1.75570960
87	Keratoconus (HP:0000563)	1.75306523
88	Increased corneal curvature (HP:0100692)	1.75306523
89	Oral leukoplakia (HP:0002745)	1.75188370
90	Severe visual impairment (HP:0001141)	1.74476245
91	Methylmalonic aciduria (HP:0012120)	1.73346889
92	Type 2 muscle fiber atrophy (HP:0003554)	1.70966095
93	Cystic liver disease (HP:0006706)	1.70279031
94	Chronic mucocutaneous candidiasis (HP:0002728)	1.69212465
95	Recurrent cutaneous fungal infections (HP:0011370)	1.69212465
96	Abnormality of the renal medulla (HP:0100957)	1.68732407
97	Hyperphosphaturia (HP:0003109)	1.67968282
98	Hypoplasia of the thymus (HP:0000778)	1.66532169
99	Respiratory difficulties (HP:0002880)	1.66284104
100	Abnormality of T cell physiology (HP:0011840)	1.66245869

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.82593027
2	KDR	4.42949972
3	TESK2	3.33245253
4	ZAK	2.98880530
5	BCKDK	2.72917183
6	VRK2	2.69413779
7	MAP4K1	2.59017356
8	ADRBK2	2.57289284
9	TAOK3	2.44538126
10	CDK19	2.42557116
11	TLK1	2.39221756
12	NUAK1	2.20030177
13	GRK1	2.10875652
14	MUSK	1.90325409
15	PINK1	1.90287699
16	ITK	1.87320897
17	TIE1	1.85107332
18	PASK	1.82919235
19	MAP4K2	1.79438908
20	WNK4	1.74409554
21	TEC	1.69966389
22	VRK1	1.68007154
23	FES	1.62792615
24	MAP3K11	1.54354788
25	LIMK1	1.46984617
26	GRK6	1.35301845
27	PRKCQ	1.31272491
28	BTK	1.26444389
29	SYK	1.21847875
30	TNK2	1.21368100
31	NME1	1.21335851
32	KIT	1.15159694
33	MAP3K12	1.14159169
34	CAMKK1	1.14048294
35	TESK1	1.11683207
36	FRK	1.10184348
37	CAMKK2	1.09795312
38	BMPR1B	1.05891889
39	LCK	1.01503579
40	IKBKB	0.93750571
41	OXSR1	0.86188914
42	CSK	0.86078826
43	PIK3CA	0.85369852
44	BUB1	0.84276634
45	STK39	0.82787032
46	GRK7	0.80746476
47	DYRK2	0.80078856
48	SCYL2	0.79010873
49	MST4	0.77599316
50	LYN	0.77422802
51	WNK3	0.74474338
52	MATK	0.73413244
53	INSRR	0.72122465
54	ADRBK1	0.71959630
55	MYLK	0.69720764
56	AURKA	0.68157337
57	TYRO3	0.66336433
58	RPS6KA5	0.65844928
59	PIK3CG	0.64223866
60	NEK1	0.64195146
61	CSF1R	0.63228118
62	OBSCN	0.62693118
63	DAPK2	0.61024575
64	LRRK2	0.59345173
65	NME2	0.58095502
66	ZAP70	0.56451394
67	JAK3	0.56016589
68	PRKCH	0.53243845
69	STK16	0.52381259
70	PLK4	0.52151036
71	DAPK3	0.50828252
72	NEK2	0.50055183
73	CAMK1	0.49577151
74	IGF1R	0.49566705
75	PIM1	0.48537419
76	MAP2K6	0.47713010
77	PRKCA	0.46499408
78	FLT3	0.45597164
79	PRKACA	0.44650820
80	PRKCG	0.43483955
81	IKBKE	0.43229921
82	DAPK1	0.41617867
83	CSNK2A1	0.41527397
84	PLK1	0.39121494
85	CSNK2A2	0.38801286
86	MAP2K7	0.37667225
87	CDC7	0.34855397
88	PRKCD	0.34678747
89	GRK5	0.32968140
90	ATR	0.32519046
91	FYN	0.30440842
92	AURKB	0.30023178
93	CAMK2A	0.28582502
94	MAPKAPK3	0.28474413
95	ILK	0.28158360
96	INSR	0.28019839
97	TGFBR1	0.26428206
98	CHEK2	0.23794660
99	TBK1	0.23721576
100	MAPK13	0.22963607

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.89833727
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.39851507
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.73405908
4	Proteasome_Homo sapiens_hsa03050	3.30443447
5	Parkinsons disease_Homo sapiens_hsa05012	3.03857623
6	RNA polymerase_Homo sapiens_hsa03020	2.47315311
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.33163760
8	Allograft rejection_Homo sapiens_hsa05330	2.31951659
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.21116509
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.09817586
11	Alzheimers disease_Homo sapiens_hsa05010	2.02462567
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.00353540
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88754832
14	Huntingtons disease_Homo sapiens_hsa05016	1.88252576
15	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.84627012
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79916583
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.75881101
18	Phototransduction_Homo sapiens_hsa04744	1.74802535
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.67209999
20	Protein export_Homo sapiens_hsa03060	1.61873757
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.61283623
22	Asthma_Homo sapiens_hsa05310	1.50301012
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46470584
24	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.45808597
25	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.37991665
26	Homologous recombination_Homo sapiens_hsa03440	1.35687907
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.31668132
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22557979
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20444314
30	One carbon pool by folate_Homo sapiens_hsa00670	1.20324292
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.19663146
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.18861768
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18618460
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14783958
35	RNA degradation_Homo sapiens_hsa03018	1.14410663
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11516585
37	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.10485967
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.07185917
39	Peroxisome_Homo sapiens_hsa04146	1.01482520
40	Basal transcription factors_Homo sapiens_hsa03022	0.98017209
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86391893
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84415027
43	Purine metabolism_Homo sapiens_hsa00230	0.84096629
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82795125
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82196291
46	Caffeine metabolism_Homo sapiens_hsa00232	0.81998806
47	Retinol metabolism_Homo sapiens_hsa00830	0.81413967
48	Olfactory transduction_Homo sapiens_hsa04740	0.81300376
49	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.80297304
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79203545
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78346363
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78211668
53	Butanoate metabolism_Homo sapiens_hsa00650	0.75598981
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.75031425
55	Mismatch repair_Homo sapiens_hsa03430	0.74912744
56	Sulfur metabolism_Homo sapiens_hsa00920	0.74570701
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73373555
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70721503
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.69908236
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68841048
61	Propanoate metabolism_Homo sapiens_hsa00640	0.67483134
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.67425939
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.67105828
64	Malaria_Homo sapiens_hsa05144	0.67095705
65	Base excision repair_Homo sapiens_hsa03410	0.66616876
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64193002
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62836619
68	Sulfur relay system_Homo sapiens_hsa04122	0.60696951
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58736236
70	Metabolic pathways_Homo sapiens_hsa01100	0.55487998
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.55442492
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.55204769
73	DNA replication_Homo sapiens_hsa03030	0.54892059
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53832088
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52700816
76	Measles_Homo sapiens_hsa05162	0.52594399
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50631055
78	Spliceosome_Homo sapiens_hsa03040	0.50071533
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49767563
80	Viral myocarditis_Homo sapiens_hsa05416	0.49277025
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48994880
82	RNA transport_Homo sapiens_hsa03013	0.48689486
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45558415
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.45112836
85	Taste transduction_Homo sapiens_hsa04742	0.44224077
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43748609
87	Nicotine addiction_Homo sapiens_hsa05033	0.43392863
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41373961
89	Regulation of autophagy_Homo sapiens_hsa04140	0.36857124
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33379963
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.31445098
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30696200
93	Morphine addiction_Homo sapiens_hsa05032	0.30386247
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.25234784
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23095827
96	Salivary secretion_Homo sapiens_hsa04970	0.22446952
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.20158518
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.18994456
99	Glutathione metabolism_Homo sapiens_hsa00480	0.17708122
100	Salmonella infection_Homo sapiens_hsa05132	0.16205401

RPL13AP25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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