ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.18765394
2	translational termination (GO:0006415)	7.82768830
3	ribosomal small subunit assembly (GO:0000028)	7.68262997
4	translational elongation (GO:0006414)	6.69167595
5	ribosomal small subunit biogenesis (GO:0042274)	6.66435510
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.59548209
7	cotranslational protein targeting to membrane (GO:0006613)	6.50295542
8	protein targeting to ER (GO:0045047)	6.48472349
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.19341939
10	protein localization to endoplasmic reticulum (GO:0070972)	6.07482863
11	cellular protein complex disassembly (GO:0043624)	5.93682583
12	maturation of SSU-rRNA (GO:0030490)	5.82058810
13	viral life cycle (GO:0019058)	5.79738408
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.68234737
15	ATP synthesis coupled proton transport (GO:0015986)	5.68234737
16	DNA deamination (GO:0045006)	5.60023585
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.59703650
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.52631002
19	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.52567180
20	translational initiation (GO:0006413)	5.14128092
21	protein complex disassembly (GO:0043241)	4.96431237
22	cytidine metabolic process (GO:0046087)	4.73732550
23	cytidine catabolic process (GO:0006216)	4.73732550
24	cytidine deamination (GO:0009972)	4.73732550
25	chaperone-mediated protein transport (GO:0072321)	4.69987694
26	macromolecular complex disassembly (GO:0032984)	4.66718788
27	behavioral response to nicotine (GO:0035095)	4.35588345
28	ribosomal large subunit biogenesis (GO:0042273)	4.35434274
29	protein targeting to membrane (GO:0006612)	4.27164477
30	protein neddylation (GO:0045116)	4.17978782
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.15002296
32	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.11164876
33	protein complex biogenesis (GO:0070271)	4.09900627
34	* translation (GO:0006412)	4.06261867
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.96935795
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.96935795
37	NADH dehydrogenase complex assembly (GO:0010257)	3.96935795
38	respiratory electron transport chain (GO:0022904)	3.95635340
39	electron transport chain (GO:0022900)	3.92616250
40	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.89516383
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.70434269
42	mRNA catabolic process (GO:0006402)	3.68076155
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.65543583
44	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.57575198
45	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.57575198
46	negative regulation of telomere maintenance (GO:0032205)	3.56210263
47	ATP biosynthetic process (GO:0006754)	3.38599030
48	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.32201675
49	RNA catabolic process (GO:0006401)	3.30493305
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.28219822
51	cellular component biogenesis (GO:0044085)	3.15065936
52	GTP biosynthetic process (GO:0006183)	3.11943383
53	water-soluble vitamin biosynthetic process (GO:0042364)	3.10482480
54	ribonucleoprotein complex biogenesis (GO:0022613)	3.06232209
55	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.05280633
56	hydrogen ion transmembrane transport (GO:1902600)	3.04524322
57	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.94596373
58	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.94336463
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.93972014
60	cell proliferation in forebrain (GO:0021846)	2.91652059
61	somite development (GO:0061053)	2.88005796
62	positive regulation of T cell apoptotic process (GO:0070234)	2.86589701
63	termination of RNA polymerase III transcription (GO:0006386)	2.84480443
64	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.84480443
65	establishment of protein localization to membrane (GO:0090150)	2.83528827
66	negative regulation of telomerase activity (GO:0051974)	2.81556150
67	substrate-independent telencephalic tangential migration (GO:0021826)	2.81146325
68	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.81146325
69	positive regulation of cell fate commitment (GO:0010455)	2.78592210
70	proton transport (GO:0015992)	2.77283845
71	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.76767534
72	CTP biosynthetic process (GO:0006241)	2.74158856
73	CTP metabolic process (GO:0046036)	2.74158856
74	rRNA processing (GO:0006364)	2.73137895
75	rRNA metabolic process (GO:0016072)	2.71885728
76	regulation of isotype switching to IgG isotypes (GO:0048302)	2.70471708
77	regulation of activation of Janus kinase activity (GO:0010533)	2.69725671
78	hydrogen transport (GO:0006818)	2.69240053
79	cellular anion homeostasis (GO:0030002)	2.65596963
80	protein targeting (GO:0006605)	2.64338863
81	positive regulation of respiratory burst (GO:0060267)	2.57837778
82	nucleoside triphosphate biosynthetic process (GO:0009142)	2.57676891
83	regulation of telomerase activity (GO:0051972)	2.57178475
84	platelet dense granule organization (GO:0060155)	2.56583867
85	negative regulation of T cell differentiation in thymus (GO:0033085)	2.56218058
86	protein-cofactor linkage (GO:0018065)	2.55158815
87	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.55049685
88	UTP biosynthetic process (GO:0006228)	2.54736333
89	positive regulation of defense response to virus by host (GO:0002230)	2.53996413
90	tongue development (GO:0043586)	2.53862384
91	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.52574910
92	establishment of protein localization to organelle (GO:0072594)	2.52167820
93	cytochrome complex assembly (GO:0017004)	2.49049364
94	respiratory chain complex IV assembly (GO:0008535)	2.47315650
95	pyrimidine nucleotide catabolic process (GO:0006244)	2.44980754
96	sequestering of actin monomers (GO:0042989)	2.44436091
97	positive regulation of prostaglandin secretion (GO:0032308)	2.42744703
98	fucose catabolic process (GO:0019317)	2.40182563
99	L-fucose metabolic process (GO:0042354)	2.40182563
100	L-fucose catabolic process (GO:0042355)	2.40182563

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.40111168
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.00608935
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.76125346
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.23655785
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.97189458
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.89370355
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.78630964
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76621546
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75029351
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.53103856
11	VDR_22108803_ChIP-Seq_LS180_Human	2.32616906
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30736939
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.30039741
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.00493809
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96773595
16	MYC_18940864_ChIP-ChIP_HL60_Human	1.94443130
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92451741
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.85840551
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.81969961
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.75336876
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74190504
22	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.61333192
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.60920533
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.58461497
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57697784
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51946196
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.48953916
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47306403
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.47197397
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.42129797
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41032445
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40500374
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.39849855
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.38030808
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37205971
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.37154002
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36932548
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35211820
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33200365
40	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.32492567
41	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.31384781
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29391593
43	ERA_21632823_ChIP-Seq_H3396_Human	1.28726443
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28144652
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.28111883
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.26936452
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.25816051
48	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.25327847
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24558395
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24303537
51	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.24272172
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23543930
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23084314
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23084314
55	NCOR_22424771_ChIP-Seq_293T_Human	1.21498110
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20165122
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19956049
58	AR_20517297_ChIP-Seq_VCAP_Human	1.19375218
59	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19230464
60	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.19101471
61	XRN2_22483619_ChIP-Seq_HELA_Human	1.18004765
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16933261
63	EWS_26573619_Chip-Seq_HEK293_Human	1.16675076
64	CTCF_20526341_ChIP-Seq_ESCs_Human	1.12625696
65	P53_21459846_ChIP-Seq_SAOS-2_Human	1.12124825
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.11727452
67	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.11464878
68	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09731290
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09664016
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09239349
71	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.07498828
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06848376
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06306176
74	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06289680
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06231858
76	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04932177
77	FUS_26573619_Chip-Seq_HEK293_Human	1.04927323
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04187532
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03942385
80	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03430280
81	MYC_19829295_ChIP-Seq_ESCs_Human	1.02937845
82	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01923676
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01517150
84	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01451181
85	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01324637
86	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00265289
87	BCL6_27268052_Chip-Seq_Bcells_Human	0.99428756
88	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99029056
89	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.98736874
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97990667
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96033424
92	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94801781
93	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.94025690
94	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.93852130
95	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93220919
96	SA1_27219007_Chip-Seq_Bcells_Human	0.93060514
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.92645463
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92537231
99	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.91645618
100	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.91066457

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.01970239
2	MP0006292_abnormal_olfactory_placode	4.58746320
3	MP0002234_abnormal_pharynx_morphology	3.34899103
4	MP0005671_abnormal_response_to	2.61884388
5	MP0002653_abnormal_ependyma_morphology	2.57975413
6	MP0002163_abnormal_gland_morphology	2.55422340
7	MP0003646_muscle_fatigue	2.43680457
8	MP0001873_stomach_inflammation	2.29848363
9	MP0003787_abnormal_imprinting	2.24695375
10	MP0008789_abnormal_olfactory_epithelium	2.02383288
11	MP0008877_abnormal_DNA_methylation	1.99925176
12	MP0002102_abnormal_ear_morphology	1.85221367
13	MP0004142_abnormal_muscle_tone	1.82936159
14	MP0006072_abnormal_retinal_apoptosis	1.74472055
15	MP0002837_dystrophic_cardiac_calcinosis	1.72252906
16	MP0008872_abnormal_physiological_respon	1.68383802
17	MP0008875_abnormal_xenobiotic_pharmacok	1.66587787
18	MP0005551_abnormal_eye_electrophysiolog	1.64691465
19	MP0003011_delayed_dark_adaptation	1.63999465
20	MP0000049_abnormal_middle_ear	1.61130209
21	MP0005499_abnormal_olfactory_system	1.60675830
22	MP0005394_taste/olfaction_phenotype	1.60675830
23	MP0004885_abnormal_endolymph	1.58564134
24	MP0005377_hearing/vestibular/ear_phenot	1.55869752
25	MP0003878_abnormal_ear_physiology	1.55869752
26	MP0005645_abnormal_hypothalamus_physiol	1.52961631
27	MP0005379_endocrine/exocrine_gland_phen	1.48106734
28	MP0001293_anophthalmia	1.47087616
29	MP0001485_abnormal_pinna_reflex	1.43251591
30	MP0006276_abnormal_autonomic_nervous	1.40361449
31	MP0001188_hyperpigmentation	1.34444051
32	MP0002277_abnormal_respiratory_mucosa	1.33193020
33	MP0004147_increased_porphyrin_level	1.33100145
34	MP0000372_irregular_coat_pigmentation	1.28340510
35	MP0000631_abnormal_neuroendocrine_gland	1.26828580
36	MP0002938_white_spotting	1.24707739
37	MP0001968_abnormal_touch/_nociception	1.24666811
38	MP0005646_abnormal_pituitary_gland	1.24042078
39	MP0002736_abnormal_nociception_after	1.20433638
40	MP0003880_abnormal_central_pattern	1.20085707
41	MP0000566_synostosis	1.19619090
42	MP0005389_reproductive_system_phenotype	1.16935413
43	MP0002638_abnormal_pupillary_reflex	1.16800625
44	MP0001905_abnormal_dopamine_level	1.15400751
45	MP0001919_abnormal_reproductive_system	1.13536910
46	MP0010030_abnormal_orbit_morphology	1.13201621
47	MP0004145_abnormal_muscle_electrophysio	1.12729840
48	MP0001986_abnormal_taste_sensitivity	1.09379020
49	MP0002272_abnormal_nervous_system	1.07940126
50	MP0008995_early_reproductive_senescence	1.06764098
51	MP0004133_heterotaxia	1.06738812
52	MP0001800_abnormal_humoral_immune	1.05536986
53	MP0005075_abnormal_melanosome_morpholog	1.05043033
54	MP0001984_abnormal_olfaction	1.03582805
55	MP0004742_abnormal_vestibular_system	1.02951343
56	MP0005084_abnormal_gallbladder_morpholo	1.02605734
57	MP0002095_abnormal_skin_pigmentation	1.01544039
58	MP0001440_abnormal_grooming_behavior	1.00766341
59	MP0001835_abnormal_antigen_presentation	1.00581104
60	MP0002160_abnormal_reproductive_system	0.99832757
61	MP0001529_abnormal_vocalization	0.99174369
62	MP0005253_abnormal_eye_physiology	0.98546829
63	MP0003122_maternal_imprinting	0.98184821
64	MP0003938_abnormal_ear_development	0.97401823
65	MP0005423_abnormal_somatic_nervous	0.97130822
66	MP0001663_abnormal_digestive_system	0.95446595
67	MP0009745_abnormal_behavioral_response	0.95143887
68	MP0003136_yellow_coat_color	0.93490513
69	MP0005195_abnormal_posterior_eye	0.93292123
70	MP0003121_genomic_imprinting	0.93070031
71	MP0002822_catalepsy	0.91201447
72	MP0002876_abnormal_thyroid_physiology	0.90405344
73	MP0003763_abnormal_thymus_physiology	0.90153490
74	MP0001348_abnormal_lacrimal_gland	0.88036605
75	MP0005360_urolithiasis	0.86534747
76	MP0000026_abnormal_inner_ear	0.86431890
77	MP0003283_abnormal_digestive_organ	0.83808163
78	MP0009333_abnormal_splenocyte_physiolog	0.82885269
79	MP0002752_abnormal_somatic_nervous	0.82453190
80	MP0002138_abnormal_hepatobiliary_system	0.80842052
81	MP0002148_abnormal_hypersensitivity_rea	0.80278920
82	MP0002733_abnormal_thermal_nociception	0.79498617
83	MP0002723_abnormal_immune_serum	0.79403364
84	MP0003123_paternal_imprinting	0.78856742
85	MP0001970_abnormal_pain_threshold	0.78836805
86	MP0002184_abnormal_innervation	0.77137439
87	MP0008058_abnormal_DNA_repair	0.76692041
88	MP0005000_abnormal_immune_tolerance	0.75649983
89	MP0009785_altered_susceptibility_to	0.75503758
90	MP0005174_abnormal_tail_pigmentation	0.73140776
91	MP0005387_immune_system_phenotype	0.71923414
92	MP0001790_abnormal_immune_system	0.71923414
93	MP0003866_abnormal_defecation	0.71858559
94	MP0001963_abnormal_hearing_physiology	0.70882039
95	MP0002420_abnormal_adaptive_immunity	0.70153545
96	MP0001819_abnormal_immune_cell	0.68838903
97	MP0003567_abnormal_fetal_cardiomyocyte	0.68094676
98	MP0005381_digestive/alimentary_phenotyp	0.66078751
99	MP0009764_decreased_sensitivity_to	0.65341251
100	MP0003806_abnormal_nucleotide_metabolis	0.65317077

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.53691077
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.35480017
3	Acute necrotizing encephalopathy (HP:0006965)	4.06975067
4	Increased hepatocellular lipid droplets (HP:0006565)	3.88109893
5	Mitochondrial inheritance (HP:0001427)	3.87471795
6	Abnormal number of erythroid precursors (HP:0012131)	3.82015873
7	Macrocytic anemia (HP:0001972)	3.67400787
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.61945587
9	Increased IgM level (HP:0003496)	3.57624966
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.56430202
11	Lipid accumulation in hepatocytes (HP:0006561)	3.51093766
12	Acute encephalopathy (HP:0006846)	3.44259207
13	Renal Fanconi syndrome (HP:0001994)	3.42370556
14	Abnormality of midbrain morphology (HP:0002418)	3.39514898
15	Molar tooth sign on MRI (HP:0002419)	3.39514898
16	Increased CSF lactate (HP:0002490)	3.36393524
17	Progressive macrocephaly (HP:0004481)	3.25992969
18	Pancreatic fibrosis (HP:0100732)	3.14605983
19	Pancreatic cysts (HP:0001737)	3.09054950
20	Congenital stationary night blindness (HP:0007642)	3.06066247
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.94066797
22	Increased intramyocellular lipid droplets (HP:0012240)	2.91447717
23	Pallor (HP:0000980)	2.85959456
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84869673
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84869673
26	Hepatocellular necrosis (HP:0001404)	2.74344911
27	True hermaphroditism (HP:0010459)	2.67499490
28	IgG deficiency (HP:0004315)	2.66967859
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.65025794
30	Autoimmune thrombocytopenia (HP:0001973)	2.64661376
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.64106181
32	Cerebral edema (HP:0002181)	2.63068429
33	Type II lissencephaly (HP:0007260)	2.62892970
34	Exertional dyspnea (HP:0002875)	2.62859730
35	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.59282414
36	3-Methylglutaconic aciduria (HP:0003535)	2.58239405
37	Nephronophthisis (HP:0000090)	2.50180970
38	Hepatic necrosis (HP:0002605)	2.45615901
39	Septo-optic dysplasia (HP:0100842)	2.44393064
40	Increased muscle lipid content (HP:0009058)	2.41806981
41	Optic disc pallor (HP:0000543)	2.41682599
42	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.37483181
43	Absent/shortened dynein arms (HP:0200106)	2.37483181
44	Rib fusion (HP:0000902)	2.30459013
45	Abnormality of renal resorption (HP:0011038)	2.27505891
46	Hyperglycinemia (HP:0002154)	2.27196676
47	Severe combined immunodeficiency (HP:0004430)	2.26515614
48	Medial flaring of the eyebrow (HP:0010747)	2.25709927
49	Polydipsia (HP:0001959)	2.25247267
50	Abnormal drinking behavior (HP:0030082)	2.25247267
51	Asplenia (HP:0001746)	2.23403588
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.22369777
53	Pendular nystagmus (HP:0012043)	2.21942323
54	Stomatitis (HP:0010280)	2.21355371
55	Congenital, generalized hypertrichosis (HP:0004540)	2.21060012
56	Abnormality of eosinophils (HP:0001879)	2.20505711
57	Aplastic anemia (HP:0001915)	2.19432142
58	Abnormality of urine glucose concentration (HP:0011016)	2.19305292
59	Glycosuria (HP:0003076)	2.19305292
60	Colon cancer (HP:0003003)	2.18438612
61	Absent thumb (HP:0009777)	2.17743755
62	Stenosis of the external auditory canal (HP:0000402)	2.17037379
63	Cystic liver disease (HP:0006706)	2.16074757
64	Abnormality of T cell number (HP:0011839)	2.13716532
65	Sclerocornea (HP:0000647)	2.13267253
66	Increased serum lactate (HP:0002151)	2.09019366
67	Abolished electroretinogram (ERG) (HP:0000550)	2.06417991
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.05782738
69	Autoimmune hemolytic anemia (HP:0001890)	2.05391061
70	Lactic acidosis (HP:0003128)	2.04260177
71	Respiratory difficulties (HP:0002880)	2.02457710
72	Hyperphosphaturia (HP:0003109)	2.02143191
73	Abnormality of the renal medulla (HP:0100957)	2.01196210
74	Abnormal respiratory epithelium morphology (HP:0012253)	2.00344412
75	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00344412
76	Lethargy (HP:0001254)	1.96670552
77	Abnormality of T cells (HP:0002843)	1.92525665
78	Decreased central vision (HP:0007663)	1.92222995
79	Abnormality of the renal cortex (HP:0011035)	1.90813630
80	Anterior segment dysgenesis (HP:0007700)	1.90355237
81	Respiratory failure (HP:0002878)	1.89012685
82	Chronic hepatic failure (HP:0100626)	1.88348829
83	Nonprogressive disorder (HP:0003680)	1.88128767
84	Abnormality of the renal collecting system (HP:0004742)	1.85730688
85	Abnormality of T cell physiology (HP:0011840)	1.85618575
86	Abnormality of the labia minora (HP:0012880)	1.81422538
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.80569184
88	Cerebellar dysplasia (HP:0007033)	1.78505452
89	Depressed nasal ridge (HP:0000457)	1.78471514
90	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.78178690
91	Polyuria (HP:0000103)	1.77608569
92	Abnormal ciliary motility (HP:0012262)	1.77285021
93	Hypoplasia of the radius (HP:0002984)	1.76735119
94	Neutropenia (HP:0001875)	1.75922747
95	Supernumerary spleens (HP:0009799)	1.73294174
96	Hypoplasia of the pons (HP:0012110)	1.73099555
97	Methylmalonic acidemia (HP:0002912)	1.71812911
98	Abnormality of the pons (HP:0007361)	1.71674999
99	Thyroiditis (HP:0100646)	1.70587988
100	Constricted visual fields (HP:0001133)	1.68491268

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.75849500
2	BCKDK	3.36161732
3	TXK	3.31333741
4	CDK19	3.12046266
5	VRK2	3.06812330
6	PIK3CA	2.54872787
7	ADRBK2	2.45114115
8	WNK4	2.42137217
9	TAOK3	2.21027065
10	ZAK	2.11238225
11	MAP4K2	2.08305923
12	GRK1	2.04301746
13	NUAK1	1.86108213
14	KDR	1.83299518
15	STK16	1.83023642
16	DYRK2	1.69287791
17	LIMK1	1.68861629
18	MAP4K1	1.60825248
19	TESK2	1.59280929
20	TIE1	1.52109022
21	OXSR1	1.50199064
22	VRK1	1.47324531
23	PASK	1.39750576
24	MAP2K6	1.39472247
25	CAMKK2	1.39253593
26	NME1	1.35345710
27	KIT	1.35162686
28	TAF1	1.34122809
29	PINK1	1.26112442
30	MAP3K11	1.23969790
31	FRK	1.10796296
32	BMPR1B	1.10224589
33	WNK3	1.05913790
34	TEC	1.04778006
35	GRK7	1.02515362
36	STK39	0.97780603
37	MUSK	0.97425332
38	PRKCQ	0.96770708
39	EPHB2	0.94397954
40	PRKCG	0.93762716
41	GRK6	0.88618516
42	ITK	0.88099629
43	ADRBK1	0.88064218
44	PLK4	0.86837658
45	BTK	0.80852175
46	GRK5	0.79467093
47	LRRK2	0.78763587
48	IKBKB	0.76498362
49	INSRR	0.76223496
50	CDK8	0.74069125
51	CAMKK1	0.73082232
52	SYK	0.70242337
53	LCK	0.69241276
54	DAPK3	0.68451800
55	AURKA	0.64544756
56	CAMK1	0.62684793
57	STK11	0.61149912
58	RPS6KA5	0.59650810
59	MATK	0.58174916
60	CSNK2A2	0.55035078
61	TNIK	0.52378520
62	MAP3K12	0.52074864
63	PRKACA	0.52063638
64	MST4	0.50376000
65	DAPK2	0.49818529
66	CDC7	0.49304154
67	PAK3	0.49214031
68	CSNK1G1	0.48529934
69	MAP3K4	0.46149672
70	MAPK13	0.45669758
71	PIM1	0.45009230
72	TNK2	0.44330613
73	PRKCA	0.42796583
74	PRKCH	0.42784072
75	RPS6KA6	0.42695280
76	CSNK1G3	0.42679384
77	LYN	0.42586709
78	FES	0.42567342
79	OBSCN	0.42435958
80	CSNK2A1	0.41879127
81	MARK3	0.41287626
82	IKBKE	0.40648618
83	NME2	0.39134049
84	NTRK2	0.39126063
85	MAP3K6	0.38981139
86	TESK1	0.38494955
87	CSNK1G2	0.38220458
88	PHKG1	0.37231018
89	PHKG2	0.37231018
90	MAP2K7	0.36246070
91	SGK223	0.35428283
92	SGK494	0.35428283
93	NEK2	0.33976900
94	WNK1	0.33790500
95	AURKB	0.33627817
96	TAOK2	0.33594075
97	TGFBR1	0.33529617
98	CHEK2	0.32361638
99	MAPKAPK5	0.31590535
100	CSNK1A1	0.30748395

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.56823143
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.18067653
3	Parkinsons disease_Homo sapiens_hsa05012	3.28131271
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.77616000
5	RNA polymerase_Homo sapiens_hsa03020	2.42898645
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.31053680
7	Alzheimers disease_Homo sapiens_hsa05010	2.27990667
8	Huntingtons disease_Homo sapiens_hsa05016	2.25053963
9	Sulfur relay system_Homo sapiens_hsa04122	2.21594744
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.18789038
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.16281691
12	Caffeine metabolism_Homo sapiens_hsa00232	2.14751786
13	Proteasome_Homo sapiens_hsa03050	2.11643372
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87987558
15	Protein export_Homo sapiens_hsa03060	1.87027538
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.80064254
17	Phototransduction_Homo sapiens_hsa04744	1.79249817
18	Allograft rejection_Homo sapiens_hsa05330	1.73388247
19	Homologous recombination_Homo sapiens_hsa03440	1.64860719
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.62615146
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.58272835
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55350433
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38207058
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36087790
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.31954029
26	RNA degradation_Homo sapiens_hsa03018	1.28232502
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.28153362
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27876784
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.20807366
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13672820
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13574391
32	Asthma_Homo sapiens_hsa05310	1.08631907
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.06378305
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02012352
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00727117
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.00542742
37	Mismatch repair_Homo sapiens_hsa03430	1.00251048
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.00134149
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.98588582
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97469843
41	Basal transcription factors_Homo sapiens_hsa03022	0.94984862
42	Retinol metabolism_Homo sapiens_hsa00830	0.94742453
43	Nitrogen metabolism_Homo sapiens_hsa00910	0.93526271
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.89865089
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86264052
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85636321
47	One carbon pool by folate_Homo sapiens_hsa00670	0.85316457
48	Peroxisome_Homo sapiens_hsa04146	0.85217398
49	DNA replication_Homo sapiens_hsa03030	0.84895747
50	Nicotine addiction_Homo sapiens_hsa05033	0.84679893
51	Purine metabolism_Homo sapiens_hsa00230	0.84321749
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.84022860
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82341202
54	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.81485097
55	Antigen processing and presentation_Homo sapiens_hsa04612	0.78258905
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75608651
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75230030
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73078530
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70796195
60	Folate biosynthesis_Homo sapiens_hsa00790	0.69689658
61	Butanoate metabolism_Homo sapiens_hsa00650	0.69126483
62	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66576543
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65918166
64	Propanoate metabolism_Homo sapiens_hsa00640	0.65621484
65	Olfactory transduction_Homo sapiens_hsa04740	0.62454064
66	Metabolic pathways_Homo sapiens_hsa01100	0.62262643
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59327642
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58709330
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55389410
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.55385963
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.54866771
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53886136
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49585253
74	African trypanosomiasis_Homo sapiens_hsa05143	0.49370176
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49017277
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48140440
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47135380
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44694285
79	Base excision repair_Homo sapiens_hsa03410	0.44519078
80	Spliceosome_Homo sapiens_hsa03040	0.44353359
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43360973
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42871440
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41365534
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40282002
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.38974584
86	Morphine addiction_Homo sapiens_hsa05032	0.38590912
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.38219869
88	Taste transduction_Homo sapiens_hsa04742	0.36233112
89	RNA transport_Homo sapiens_hsa03013	0.36004293
90	Measles_Homo sapiens_hsa05162	0.30367654
91	Mineral absorption_Homo sapiens_hsa04978	0.29562217
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.28930934
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28074505
94	Regulation of autophagy_Homo sapiens_hsa04140	0.26491213
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.23928742
96	Malaria_Homo sapiens_hsa05144	0.22789990
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.19356558
98	Salivary secretion_Homo sapiens_hsa04970	0.19185380
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18372552
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.16616743

RPL13AP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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