ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.19979537
2	ribosomal small subunit assembly (GO:0000028)	8.25755505
3	viral transcription (GO:0019083)	7.98922785
4	translational termination (GO:0006415)	7.75193848
5	translational elongation (GO:0006414)	6.62916611
6	cotranslational protein targeting to membrane (GO:0006613)	6.16686303
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.11810605
8	protein targeting to ER (GO:0045047)	6.11274804
9	ATP synthesis coupled proton transport (GO:0015986)	5.82980463
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.82980463
11	cellular protein complex disassembly (GO:0043624)	5.82735679
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.80086921
13	protein localization to endoplasmic reticulum (GO:0070972)	5.77705018
14	viral life cycle (GO:0019058)	5.72266630
15	maturation of SSU-rRNA (GO:0030490)	5.69252950
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.64226302
17	protein complex disassembly (GO:0043241)	4.92552054
18	translational initiation (GO:0006413)	4.87052187
19	macromolecular complex disassembly (GO:0032984)	4.67357594
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.62888659
21	NADH dehydrogenase complex assembly (GO:0010257)	4.62888659
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.62888659
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.29187898
24	ribonucleoprotein complex biogenesis (GO:0022613)	4.28288802
25	DNA deamination (GO:0045006)	4.26463139
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.22650290
27	ribosomal large subunit biogenesis (GO:0042273)	4.19473573
28	chaperone-mediated protein transport (GO:0072321)	4.18602191
29	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.17433283
30	maternal behavior (GO:0042711)	4.14098417
31	protein targeting to membrane (GO:0006612)	4.13639690
32	translation (GO:0006412)	4.08826274
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.06405268
34	cellular response to nicotine (GO:0071316)	4.02097211
35	cellular component biogenesis (GO:0044085)	3.92658134
36	respiratory electron transport chain (GO:0022904)	3.91001023
37	electron transport chain (GO:0022900)	3.85291587
38	mRNA catabolic process (GO:0006402)	3.84385946
39	pyrimidine nucleotide catabolic process (GO:0006244)	3.80330724
40	ATP biosynthetic process (GO:0006754)	3.78857967
41	positive T cell selection (GO:0043368)	3.77476032
42	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.74594028
43	positive regulation of response to oxidative stress (GO:1902884)	3.70446675
44	positive regulation of cellular response to oxidative stress (GO:1900409)	3.70446675
45	neurofilament cytoskeleton organization (GO:0060052)	3.67243226
46	parental behavior (GO:0060746)	3.63857585
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.63351508
48	protein complex biogenesis (GO:0070271)	3.62459987
49	GTP biosynthetic process (GO:0006183)	3.61091553
50	positive thymic T cell selection (GO:0045059)	3.58596817
51	oxygen transport (GO:0015671)	3.56587171
52	RNA catabolic process (GO:0006401)	3.42754417
53	cardiovascular system development (GO:0072358)	3.40699870
54	superoxide anion generation (GO:0042554)	3.39668564
55	regulation of isotype switching to IgG isotypes (GO:0048302)	3.39323248
56	behavioral response to nicotine (GO:0035095)	3.31467232
57	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30505542
58	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.29859980
59	middle ear morphogenesis (GO:0042474)	3.25449513
60	hydrogen peroxide biosynthetic process (GO:0050665)	3.22928775
61	startle response (GO:0001964)	3.21758503
62	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.19986402
63	UTP biosynthetic process (GO:0006228)	3.15934846
64	axonemal dynein complex assembly (GO:0070286)	3.12435966
65	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.11409516
66	autophagic vacuole fusion (GO:0000046)	3.11118739
67	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.08336815
68	auditory receptor cell differentiation (GO:0042491)	3.04006699
69	protein-cofactor linkage (GO:0018065)	2.99295449
70	myoblast migration (GO:0051451)	2.96272927
71	reactive oxygen species biosynthetic process (GO:1903409)	2.88377090
72	hypothalamus development (GO:0021854)	2.87722538
73	regulation of B cell receptor signaling pathway (GO:0050855)	2.86358615
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.84530133
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.84530133
76	gas transport (GO:0015669)	2.82785971
77	fucose catabolic process (GO:0019317)	2.80191809
78	L-fucose metabolic process (GO:0042354)	2.80191809
79	L-fucose catabolic process (GO:0042355)	2.80191809
80	substrate-independent telencephalic tangential migration (GO:0021826)	2.79867075
81	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.79867075
82	rRNA processing (GO:0006364)	2.78069408
83	UTP metabolic process (GO:0046051)	2.76433567
84	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.75248979
85	regulation of cellular respiration (GO:0043457)	2.74767158
86	rRNA metabolic process (GO:0016072)	2.74450122
87	establishment of protein localization to organelle (GO:0072594)	2.74263937
88	protein targeting (GO:0006605)	2.73595791
89	nucleoside triphosphate biosynthetic process (GO:0009142)	2.73504100
90	outer ear morphogenesis (GO:0042473)	2.73385936
91	phenylpropanoid metabolic process (GO:0009698)	2.72734365
92	guanosine-containing compound biosynthetic process (GO:1901070)	2.72376550
93	establishment of protein localization to membrane (GO:0090150)	2.71815169
94	regulation of cilium movement (GO:0003352)	2.70793333
95	ncRNA 3-end processing (GO:0043628)	2.70434685
96	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.69614039
97	peptidyl-histidine modification (GO:0018202)	2.67164499
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.64781460
99	hydrogen ion transmembrane transport (GO:1902600)	2.64580390
100	ribosome biogenesis (GO:0042254)	2.64008217

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.11336916
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.36826258
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.20956083
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50373879
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.31008704
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.04594163
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.88808597
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.88635748
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.85364871
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83504534
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.69187015
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.48119247
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.39255728
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.36260690
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.27563691
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27451385
17	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.20996164
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.18932960
19	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.16197956
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.15977808
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.10103973
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.07678977
23	VDR_22108803_ChIP-Seq_LS180_Human	2.03301422
24	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.00609131
25	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.94028036
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.86067996
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.76414458
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75959199
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.75613032
30	* XRN2_22483619_ChIP-Seq_HELA_Human	1.71905368
31	VDR_21846776_ChIP-Seq_THP-1_Human	1.68936496
32	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.67694209
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.66863115
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.63927136
35	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.61913454
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.58552146
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.51344225
38	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.45087625
39	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.41501421
40	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40365969
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.37090314
42	STAT1_20625510_ChIP-Seq_HELA_Human	1.36390471
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.36223041
44	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.26017963
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.25804874
46	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.24069876
47	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.23799927
48	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.23141666
49	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.21164421
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20432884
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.20360196
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.20305853
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20025685
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20022530
55	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17809843
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17511391
57	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17236799
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.17179465
59	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16866710
60	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15482351
61	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.15362221
62	IGF1R_20145208_ChIP-Seq_DFB_Human	1.14028082
63	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.10811031
64	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.10811031
65	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.10811031
66	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.05434509
67	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04863634
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04205649
69	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.04090020
70	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.04081445
71	RUNX_20019798_ChIP-Seq_JUKART_Human	1.03914875
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01659852
73	SPI1_20517297_ChIP-Seq_HL60_Human	1.01397327
74	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00400873
75	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98037956
76	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.97548286
77	BCL6_27268052_Chip-Seq_Bcells_Human	0.97017490
78	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.96780350
79	MAF_26560356_Chip-Seq_TH2_Human	0.95446566
80	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94950633
81	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.94284821
82	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.94043979
83	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.94005790
84	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93615449
85	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93438982
86	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.93385711
87	ERA_21632823_ChIP-Seq_H3396_Human	0.92774140
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92708082
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91618601
90	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.90837742
91	UTX_26944678_Chip-Seq_JUKART_Human	0.90463042
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.89496292
93	MYB_26560356_Chip-Seq_TH2_Human	0.89197233
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88288593
95	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.87922197
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.87318624
97	CIITA_25753668_ChIP-Seq_RAJI_Human	0.86993629
98	GATA3_26560356_Chip-Seq_TH2_Human	0.85133071
99	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.84265625
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83998585

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.81245873
2	MP0003878_abnormal_ear_physiology	4.24828285
3	MP0005377_hearing/vestibular/ear_phenot	4.24828285
4	MP0002163_abnormal_gland_morphology	3.23441650
5	MP0000569_abnormal_digit_pigmentation	3.17142353
6	MP0004145_abnormal_muscle_electrophysio	3.01902076
7	MP0006292_abnormal_olfactory_placode	2.93741900
8	MP0002928_abnormal_bile_duct	2.69558009
9	MP0008995_early_reproductive_senescence	2.50809855
10	MP0005671_abnormal_response_to	2.44513988
11	MP0003646_muscle_fatigue	2.44059598
12	MP0003787_abnormal_imprinting	2.19171118
13	MP0004885_abnormal_endolymph	2.12708094
14	MP0003186_abnormal_redox_activity	2.12033489
15	MP0004142_abnormal_muscle_tone	2.10287190
16	MP0005075_abnormal_melanosome_morpholog	1.99963662
17	MP0004742_abnormal_vestibular_system	1.99011323
18	MP0003806_abnormal_nucleotide_metabolis	1.96133249
19	MP0005084_abnormal_gallbladder_morpholo	1.95527433
20	MP0009333_abnormal_splenocyte_physiolog	1.93106228
21	MP0001849_ear_inflammation	1.92873993
22	MP0003786_premature_aging	1.87454421
23	MP0000049_abnormal_middle_ear	1.85629435
24	MP0003763_abnormal_thymus_physiology	1.80528229
25	MP0004381_abnormal_hair_follicle	1.75916882
26	MP0005379_endocrine/exocrine_gland_phen	1.75318292
27	MP0004858_abnormal_nervous_system	1.74646399
28	MP0002277_abnormal_respiratory_mucosa	1.70384532
29	MP0000685_abnormal_immune_system	1.68582219
30	MP0001800_abnormal_humoral_immune	1.68014638
31	MP0004147_increased_porphyrin_level	1.57119941
32	MP0005174_abnormal_tail_pigmentation	1.54550635
33	MP0003195_calcinosis	1.53128030
34	MP0002095_abnormal_skin_pigmentation	1.46881697
35	MP0003656_abnormal_erythrocyte_physiolo	1.43378872
36	MP0001835_abnormal_antigen_presentation	1.36976496
37	MP0000015_abnormal_ear_pigmentation	1.35205911
38	MP0002132_abnormal_respiratory_system	1.33353007
39	MP0008058_abnormal_DNA_repair	1.32572021
40	MP0005389_reproductive_system_phenotype	1.27837360
41	MP0002405_respiratory_system_inflammati	1.27806210
42	MP0002723_abnormal_immune_serum	1.27686017
43	MP0001188_hyperpigmentation	1.23506017
44	MP0005551_abnormal_eye_electrophysiolog	1.23040180
45	MP0000703_abnormal_thymus_morphology	1.19788144
46	MP0002398_abnormal_bone_marrow	1.19625977
47	MP0000013_abnormal_adipose_tissue	1.18703945
48	MP0002102_abnormal_ear_morphology	1.15636640
49	MP0002420_abnormal_adaptive_immunity	1.15225045
50	MP0001819_abnormal_immune_cell	1.11628049
51	MP0002160_abnormal_reproductive_system	1.09693194
52	MP0008877_abnormal_DNA_methylation	1.08736102
53	MP0001270_distended_abdomen	1.06386839
54	MP0008875_abnormal_xenobiotic_pharmacok	1.05751600
55	MP0001986_abnormal_taste_sensitivity	1.04904380
56	MP0000372_irregular_coat_pigmentation	1.04685300
57	MP0001919_abnormal_reproductive_system	1.01930092
58	MP0000716_abnormal_immune_system	1.00382719
59	MP0005387_immune_system_phenotype	0.99883274
60	MP0001790_abnormal_immune_system	0.99883274
61	MP0002452_abnormal_antigen_presenting	0.95684231
62	MP0001485_abnormal_pinna_reflex	0.95553322
63	MP0001905_abnormal_dopamine_level	0.94580439
64	MP0009785_altered_susceptibility_to	0.94197073
65	MP0002722_abnormal_immune_system	0.93422675
66	MP0005000_abnormal_immune_tolerance	0.91675501
67	MP0002429_abnormal_blood_cell	0.91333002
68	MP0005025_abnormal_response_to	0.89868143
69	MP0003879_abnormal_hair_cell	0.89703850
70	MP0000689_abnormal_spleen_morphology	0.89680282
71	MP0002638_abnormal_pupillary_reflex	0.89090947
72	MP0001440_abnormal_grooming_behavior	0.86838090
73	MP0003866_abnormal_defecation	0.86494485
74	MP0000750_abnormal_muscle_regeneration	0.85902085
75	MP0000762_abnormal_tongue_morphology	0.82433530
76	MP0002148_abnormal_hypersensitivity_rea	0.81416963
77	MP0003121_genomic_imprinting	0.81002987
78	MP0001663_abnormal_digestive_system	0.78579670
79	MP0005647_abnormal_sex_gland	0.78134294
80	MP0001293_anophthalmia	0.75517337
81	MP0001764_abnormal_homeostasis	0.73439543
82	MP0000678_abnormal_parathyroid_gland	0.73391785
83	MP0005266_abnormal_metabolism	0.72648089
84	MP0006036_abnormal_mitochondrial_physio	0.72453369
85	MP0003724_increased_susceptibility_to	0.72029333
86	MP0005636_abnormal_mineral_homeostasis	0.71234419
87	MP0008872_abnormal_physiological_respon	0.70781704
88	MP0008775_abnormal_heart_ventricle	0.69598600
89	MP0004130_abnormal_muscle_cell	0.67849096
90	MP0003943_abnormal_hepatobiliary_system	0.66068033
91	MP0002210_abnormal_sex_determination	0.65148302
92	MP0010307_abnormal_tumor_latency	0.65012981
93	MP0001661_extended_life_span	0.64823054
94	MP0005195_abnormal_posterior_eye	0.64067771
95	MP0006276_abnormal_autonomic_nervous	0.63956849
96	MP0009765_abnormal_xenobiotic_induced	0.63933048
97	MP0003011_delayed_dark_adaptation	0.62971094
98	MP0005646_abnormal_pituitary_gland	0.62930714
99	MP0002938_white_spotting	0.62845211
100	MP0001873_stomach_inflammation	0.62270445

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.84480889
2	Acute necrotizing encephalopathy (HP:0006965)	4.63028964
3	Acute encephalopathy (HP:0006846)	4.54194201
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.52867739
5	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.47486240
6	Reticulocytopenia (HP:0001896)	4.25533610
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.20574357
8	Pallor (HP:0000980)	4.00391045
9	Limb hypertonia (HP:0002509)	3.97340765
10	Mitochondrial inheritance (HP:0001427)	3.95843411
11	Abnormal hemoglobin (HP:0011902)	3.86276481
12	Progressive macrocephaly (HP:0004481)	3.77414307
13	Cerebral edema (HP:0002181)	3.75196970
14	Macrocytic anemia (HP:0001972)	3.70941822
15	Abnormal number of erythroid precursors (HP:0012131)	3.60838535
16	Increased CSF lactate (HP:0002490)	3.59788601
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.36499320
18	Absent/shortened dynein arms (HP:0200106)	3.36499320
19	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.35805788
20	Increased hepatocellular lipid droplets (HP:0006565)	3.10849609
21	Increased intramyocellular lipid droplets (HP:0012240)	3.08591305
22	Abnormal rod and cone electroretinograms (HP:0008323)	3.01212707
23	3-Methylglutaconic aciduria (HP:0003535)	2.98220555
24	Lipid accumulation in hepatocytes (HP:0006561)	2.97420071
25	Abnormality of macular pigmentation (HP:0008002)	2.93154342
26	Hyperglycinemia (HP:0002154)	2.89714094
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.85250219
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.85250219
29	Renal Fanconi syndrome (HP:0001994)	2.85184940
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.80589976
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.79406678
32	Abnormal respiratory epithelium morphology (HP:0012253)	2.79406678
33	Increased muscle lipid content (HP:0009058)	2.70123800
34	Hepatocellular necrosis (HP:0001404)	2.70007441
35	Abnormality of T cells (HP:0002843)	2.62325711
36	Exertional dyspnea (HP:0002875)	2.60813614
37	Hyperglycinuria (HP:0003108)	2.54656698
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.53504066
39	Pendular nystagmus (HP:0012043)	2.47549437
40	Abnormality of T cell number (HP:0011839)	2.45342979
41	Lactic acidosis (HP:0003128)	2.41175032
42	Abnormality of DNA repair (HP:0003254)	2.39477957
43	Asplenia (HP:0001746)	2.38158220
44	T lymphocytopenia (HP:0005403)	2.35779173
45	Abnormal ciliary motility (HP:0012262)	2.34946557
46	Nephronophthisis (HP:0000090)	2.32391727
47	Hepatic necrosis (HP:0002605)	2.29128396
48	Microcytic anemia (HP:0001935)	2.24458288
49	Gastrointestinal infarctions (HP:0005244)	2.23964894
50	Respiratory difficulties (HP:0002880)	2.22960172
51	Increased serum lactate (HP:0002151)	2.20421807
52	Ketosis (HP:0001946)	2.20082347
53	Abnormality of T cell physiology (HP:0011840)	2.19434867
54	Abnormality of pyrimidine metabolism (HP:0004353)	2.16096059
55	Elevated erythrocyte sedimentation rate (HP:0003565)	2.13837536
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13523915
57	Abnormal respiratory motile cilium physiology (HP:0012261)	2.11768478
58	Septo-optic dysplasia (HP:0100842)	2.10611842
59	Poikilocytosis (HP:0004447)	2.06709254
60	Optic disc pallor (HP:0000543)	2.02458005
61	Deep palmar crease (HP:0006191)	1.99021605
62	Large eyes (HP:0001090)	1.98374562
63	Lethargy (HP:0001254)	1.98149967
64	Bilateral sensorineural hearing impairment (HP:0008619)	1.97241544
65	Hypochromic anemia (HP:0001931)	1.96710744
66	Abnormality of the renal medulla (HP:0100957)	1.96541083
67	Nasal polyposis (HP:0100582)	1.95003254
68	Congenital stationary night blindness (HP:0007642)	1.92672523
69	Decreased central vision (HP:0007663)	1.92018377
70	IgG deficiency (HP:0004315)	1.91750861
71	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.91697077
72	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.91697077
73	Vitreoretinal degeneration (HP:0000655)	1.90543690
74	Respiratory failure (HP:0002878)	1.90534649
75	Abolished electroretinogram (ERG) (HP:0000550)	1.90018606
76	Abnormality of serine family amino acid metabolism (HP:0010894)	1.86170665
77	Abnormality of glycine metabolism (HP:0010895)	1.86170665
78	Broad distal phalanx of finger (HP:0009836)	1.85245283
79	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.84994218
80	Truncus arteriosus (HP:0001660)	1.83552623
81	Hypochromic microcytic anemia (HP:0004840)	1.83016196
82	Abnormality of renal resorption (HP:0011038)	1.80697844
83	Abnormality of midbrain morphology (HP:0002418)	1.79922057
84	Molar tooth sign on MRI (HP:0002419)	1.79922057
85	Absent thumb (HP:0009777)	1.78403898
86	Stenosis of the external auditory canal (HP:0000402)	1.77185089
87	Type 2 muscle fiber atrophy (HP:0003554)	1.77023708
88	Hyperthyroidism (HP:0000836)	1.72545294
89	Agitation (HP:0000713)	1.71282585
90	Rectal prolapse (HP:0002035)	1.71121188
91	IgM deficiency (HP:0002850)	1.69992699
92	Dysphonia (HP:0001618)	1.69697069
93	Constricted visual fields (HP:0001133)	1.69365263
94	Type II lissencephaly (HP:0007260)	1.69198797
95	Exercise intolerance (HP:0003546)	1.68905699
96	Limb dystonia (HP:0002451)	1.67162927
97	Leukodystrophy (HP:0002415)	1.64831481
98	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.63783136
99	Pancytopenia (HP:0001876)	1.63687639
100	Abnormality of incisor morphology (HP:0011063)	1.62861506

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.04658380
2	BCKDK	4.03621982
3	MAP3K13	4.02133087
4	TXK	3.90531630
5	ARAF	3.33614680
6	TAOK3	3.08872750
7	MAP4K1	3.05147691
8	DMPK	2.50900803
9	MAP3K9	2.37271400
10	LRRK2	2.27449659
11	CAMKK2	2.00341541
12	IRAK4	1.99197318
13	BRAF	1.97359338
14	ZAK	1.84786161
15	BTK	1.78393414
16	RIPK4	1.71492616
17	CDK4	1.46782584
18	ADRBK2	1.44132776
19	FES	1.37811511
20	RPS6KA5	1.33341575
21	MOS	1.31845028
22	EPHA4	1.29289178
23	WNK4	1.28585112
24	RAF1	1.22588422
25	GRK1	1.22051756
26	PRKCQ	1.21393657
27	STK4	1.20196487
28	KDR	1.19695486
29	GRK6	1.18746289
30	PIK3CG	1.16937623
31	CSK	1.09177155
32	CAMK1D	1.09125978
33	SYK	1.08350781
34	PLK4	1.05295094
35	IKBKE	1.04610286
36	KSR2	1.03384927
37	CAMKK1	1.03224892
38	ITK	1.03213525
39	NUAK1	1.02069743
40	AKT3	1.00629431
41	TEC	0.97524317
42	PDK2	0.96775315
43	JAK3	0.94533403
44	RPS6KA6	0.94252683
45	PIM1	0.93537352
46	FRK	0.93275261
47	ADRBK1	0.90007890
48	IRAK2	0.85925751
49	RPS6KC1	0.85261795
50	RPS6KL1	0.85261795
51	STK11	0.84539916
52	CDK19	0.83880659
53	CDC7	0.80362315
54	LCK	0.79573727
55	DYRK2	0.77787787
56	IKBKB	0.76258103
57	SGK1	0.72868966
58	LYN	0.72290955
59	BLK	0.68931983
60	CSNK2A2	0.66122341
61	RPS6KB2	0.66096127
62	MATK	0.64217876
63	CAMK1	0.60883383
64	PASK	0.60624489
65	WNK1	0.56094609
66	DYRK1B	0.55924824
67	DYRK3	0.55117339
68	TIE1	0.54320417
69	MAPK12	0.53698058
70	MUSK	0.50496915
71	CAMK1G	0.50025599
72	TNK2	0.49086087
73	PRKCH	0.47672996
74	AURKA	0.46909606
75	PINK1	0.46443171
76	FGR	0.46323623
77	AURKB	0.45958581
78	SGK494	0.42818724
79	SGK223	0.42818724
80	MAP3K10	0.41719128
81	PRKACA	0.41202947
82	MAPKAPK5	0.40632376
83	BMPR1B	0.40612813
84	ILK	0.40256905
85	GRK5	0.39502913
86	PIK3CA	0.39396588
87	TLK1	0.38978493
88	CHEK1	0.38543341
89	ATR	0.36553626
90	MARK2	0.36437341
91	AKT1	0.36091861
92	CSNK2A1	0.35789849
93	PAK3	0.35491987
94	NLK	0.34242478
95	TYRO3	0.33245398
96	OBSCN	0.33097030
97	RPS6KA1	0.32283823
98	IGF1R	0.31251934
99	EIF2AK1	0.30900240
100	SGK3	0.30815915

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.45790197
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.44957605
3	Parkinsons disease_Homo sapiens_hsa05012	3.93525436
4	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.92313267
5	Huntingtons disease_Homo sapiens_hsa05016	2.70789230
6	Alzheimers disease_Homo sapiens_hsa05010	2.60917321
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.36340759
8	RNA polymerase_Homo sapiens_hsa03020	2.06506595
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03263770
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97253695
11	Primary immunodeficiency_Homo sapiens_hsa05340	1.94549222
12	Basal transcription factors_Homo sapiens_hsa03022	1.82829480
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82234266
14	Sulfur metabolism_Homo sapiens_hsa00920	1.80733131
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73891638
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.70309712
17	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.59436645
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.55878617
19	Sulfur relay system_Homo sapiens_hsa04122	1.45403858
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43064633
21	One carbon pool by folate_Homo sapiens_hsa00670	1.40137466
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.39703418
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.22169567
24	Allograft rejection_Homo sapiens_hsa05330	1.16291658
25	Homologous recombination_Homo sapiens_hsa03440	1.16030093
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.15326248
27	Asthma_Homo sapiens_hsa05310	1.14342332
28	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.13233906
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11908003
30	Propanoate metabolism_Homo sapiens_hsa00640	1.09623503
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08705404
32	Protein export_Homo sapiens_hsa03060	1.06110473
33	Proteasome_Homo sapiens_hsa03050	1.06078249
34	Spliceosome_Homo sapiens_hsa03040	1.00846350
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.97931465
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96848363
37	Base excision repair_Homo sapiens_hsa03410	0.93789119
38	Malaria_Homo sapiens_hsa05144	0.91322210
39	RNA degradation_Homo sapiens_hsa03018	0.90065715
40	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86727100
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85601077
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81748077
43	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.81092428
44	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79847002
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.75868637
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75041631
47	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.74889680
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74126163
49	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.73249358
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.73206500
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72541566
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.72429437
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68123290
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.65986768
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65860603
56	Purine metabolism_Homo sapiens_hsa00230	0.65486841
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65160506
58	Metabolic pathways_Homo sapiens_hsa01100	0.64971828
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63227689
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62278795
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61638116
62	Leishmaniasis_Homo sapiens_hsa05140	0.61272328
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59433548
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.57187626
65	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56893818
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55234500
67	RNA transport_Homo sapiens_hsa03013	0.53413880
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.48767001
69	Olfactory transduction_Homo sapiens_hsa04740	0.46420518
70	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45194422
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44696274
72	Mismatch repair_Homo sapiens_hsa03430	0.42022352
73	Measles_Homo sapiens_hsa05162	0.41807309
74	Phototransduction_Homo sapiens_hsa04744	0.41538709
75	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.41309907
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40185895
77	Folate biosynthesis_Homo sapiens_hsa00790	0.40040253
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.38822494
79	Chemokine signaling pathway_Homo sapiens_hsa04062	0.38498672
80	Peroxisome_Homo sapiens_hsa04146	0.37461177
81	Nicotine addiction_Homo sapiens_hsa05033	0.35541964
82	DNA replication_Homo sapiens_hsa03030	0.35253027
83	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.34443376
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.33224918
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29019770
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.28868335
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28514097
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28188340
89	Pancreatic secretion_Homo sapiens_hsa04972	0.27406445
90	Morphine addiction_Homo sapiens_hsa05032	0.26701977
91	Herpes simplex infection_Homo sapiens_hsa05168	0.26301873
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23946430
93	Non-small cell lung cancer_Homo sapiens_hsa05223	0.22557166
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.22272695
95	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.20755159
96	ABC transporters_Homo sapiens_hsa02010	0.20343972
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.19954241
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.19539655
99	Melanoma_Homo sapiens_hsa05218	0.19065014
100	Notch signaling pathway_Homo sapiens_hsa04330	0.19003931

RPL13AP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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