ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.78644798
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.13156040
3	cytidine deamination (GO:0009972)	5.63487364
4	cytidine metabolic process (GO:0046087)	5.63487364
5	cytidine catabolic process (GO:0006216)	5.63487364
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.78708735
7	ATP synthesis coupled proton transport (GO:0015986)	4.74026005
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.74026005
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.62152624
10	ribosomal small subunit assembly (GO:0000028)	4.46051135
11	behavioral response to nicotine (GO:0035095)	4.34467236
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.81680377
13	kynurenine metabolic process (GO:0070189)	3.73417339
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.72547748
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.72547748
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.72416460
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.69811484
18	maturation of SSU-rRNA (GO:0030490)	3.63955509
19	protein neddylation (GO:0045116)	3.62486666
20	protein complex biogenesis (GO:0070271)	3.58004694
21	respiratory electron transport chain (GO:0022904)	3.56048958
22	electron transport chain (GO:0022900)	3.54479694
23	viral transcription (GO:0019083)	3.50145439
24	indole-containing compound catabolic process (GO:0042436)	3.39115120
25	indolalkylamine catabolic process (GO:0046218)	3.39115120
26	tryptophan catabolic process (GO:0006569)	3.39115120
27	indolalkylamine metabolic process (GO:0006586)	3.38762365
28	translational termination (GO:0006415)	3.34257665
29	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.19675486
30	response to pheromone (GO:0019236)	3.17771517
31	mannosylation (GO:0097502)	3.17210472
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16535111
33	cotranslational protein targeting to membrane (GO:0006613)	3.14375942
34	protein targeting to ER (GO:0045047)	3.14051056
35	translational elongation (GO:0006414)	3.12710766
36	cytochrome complex assembly (GO:0017004)	3.11582861
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09420045
38	positive regulation of defense response to virus by host (GO:0002230)	3.07603128
39	base-excision repair, AP site formation (GO:0006285)	3.06029034
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.03889204
41	regulation of regulatory T cell differentiation (GO:0045589)	3.03239744
42	protein localization to endoplasmic reticulum (GO:0070972)	3.01909709
43	platelet dense granule organization (GO:0060155)	3.01075602
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00775704
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00775704
46	NADH dehydrogenase complex assembly (GO:0010257)	3.00775704
47	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.96340075
48	L-fucose catabolic process (GO:0042355)	2.93148527
49	fucose catabolic process (GO:0019317)	2.93148527
50	L-fucose metabolic process (GO:0042354)	2.93148527
51	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.88807909
52	positive T cell selection (GO:0043368)	2.87042836
53	hydrogen ion transmembrane transport (GO:1902600)	2.85191142
54	respiratory chain complex IV assembly (GO:0008535)	2.85108109
55	tryptophan metabolic process (GO:0006568)	2.84669815
56	chaperone-mediated protein transport (GO:0072321)	2.84495045
57	negative regulation of mast cell activation (GO:0033004)	2.84163825
58	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.82542962
59	adaptation of signaling pathway (GO:0023058)	2.81777682
60	ribosomal small subunit biogenesis (GO:0042274)	2.77432596
61	proton transport (GO:0015992)	2.77311645
62	GTP biosynthetic process (GO:0006183)	2.75537512
63	pseudouridine synthesis (GO:0001522)	2.73600493
64	proteasome assembly (GO:0043248)	2.73598327
65	hydrogen transport (GO:0006818)	2.73567007
66	piRNA metabolic process (GO:0034587)	2.70769147
67	GPI anchor metabolic process (GO:0006505)	2.68796567
68	DNA demethylation (GO:0080111)	2.68595639
69	preassembly of GPI anchor in ER membrane (GO:0016254)	2.68450443
70	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.64563097
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.63802173
72	ATP biosynthetic process (GO:0006754)	2.61097493
73	regulation of cellular amino acid metabolic process (GO:0006521)	2.60947860
74	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.60715554
75	positive thymic T cell selection (GO:0045059)	2.59603952
76	translation (GO:0006412)	2.58666372
77	GPI anchor biosynthetic process (GO:0006506)	2.58644121
78	sequestering of actin monomers (GO:0042989)	2.57312564
79	positive regulation of T cell apoptotic process (GO:0070234)	2.55539864
80	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.53687749
81	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.53204395
82	positive regulation of interleukin-8 secretion (GO:2000484)	2.52635537
83	ribosomal large subunit biogenesis (GO:0042273)	2.50257579
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.50113144
85	termination of RNA polymerase III transcription (GO:0006386)	2.50113144
86	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.49944927
87	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.49754053
88	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.49754053
89	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.49754053
90	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.48820700
91	epithelial cilium movement (GO:0003351)	2.48194293
92	viral life cycle (GO:0019058)	2.47942706
93	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.47471583
94	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.47471583
95	iron-sulfur cluster assembly (GO:0016226)	2.44304636
96	metallo-sulfur cluster assembly (GO:0031163)	2.44304636
97	positive regulation of T cell chemotaxis (GO:0010820)	2.44085097
98	regulation of T cell chemotaxis (GO:0010819)	2.44085097
99	deoxyribonucleotide catabolic process (GO:0009264)	2.44017809
100	cellular protein complex disassembly (GO:0043624)	2.43513257

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.79225702
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.71478228
3	VDR_22108803_ChIP-Seq_LS180_Human	3.09523271
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.04439297
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.00915404
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.00879266
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83116885
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.80988974
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76836694
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.65832186
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46329337
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.40566673
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.35483126
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.34784042
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.15550961
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.14673368
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14165978
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.07527762
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97094727
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92872383
21	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.79742563
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78635067
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.78300471
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.75806694
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.73617319
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67315389
27	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.64336428
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63930963
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54296596
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53959383
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53855959
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.53606068
33	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.45999177
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45750358
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45750358
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45666074
37	FUS_26573619_Chip-Seq_HEK293_Human	1.45239246
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.44002362
39	* EWS_26573619_Chip-Seq_HEK293_Human	1.42840257
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42195085
41	GATA3_26560356_Chip-Seq_TH2_Human	1.39824902
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38622700
43	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.38233805
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34429463
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34280851
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32461022
47	NCOR_22424771_ChIP-Seq_293T_Human	1.31992835
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30000392
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.30000392
50	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29594505
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29202190
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29202190
53	P300_19829295_ChIP-Seq_ESCs_Human	1.29144648
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28123700
55	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.28011467
56	* AR_20517297_ChIP-Seq_VCAP_Human	1.27560780
57	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.24169256
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.22556830
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21202640
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19764614
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19110120
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18809705
63	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15977911
64	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.15763425
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.15355460
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14483517
67	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.14349691
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13280671
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13019277
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12703729
71	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.12241341
72	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.11937208
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10720098
74	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10085334
75	MYB_26560356_Chip-Seq_TH2_Human	1.08986757
76	GBX2_23144817_ChIP-Seq_PC3_Human	1.08716134
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07023873
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07022567
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06488854
80	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05597962
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05210316
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04510626
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02564775
84	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01927766
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00111164
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98190541
87	* ERA_21632823_ChIP-Seq_H3396_Human	0.97694089
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97156432
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93863849
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93736124
91	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93579955
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.92427779
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.91466203
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91220185
95	GATA3_27048872_Chip-Seq_THYMUS_Human	0.90985655
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90622882
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89651348
98	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89215032
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88631210
100	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.88150088

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.97893192
2	MP0009379_abnormal_foot_pigmentation	3.36744333
3	MP0003646_muscle_fatigue	2.92173793
4	MP0001835_abnormal_antigen_presentation	2.48171427
5	MP0008875_abnormal_xenobiotic_pharmacok	2.47506124
6	MP0006292_abnormal_olfactory_placode	2.45945023
7	MP0006072_abnormal_retinal_apoptosis	2.36429105
8	MP0002102_abnormal_ear_morphology	2.17366887
9	MP0008872_abnormal_physiological_respon	2.14429928
10	MP0008877_abnormal_DNA_methylation	1.99858879
11	MP0001968_abnormal_touch/_nociception	1.92296394
12	MP0004145_abnormal_muscle_electrophysio	1.90193736
13	MP0005645_abnormal_hypothalamus_physiol	1.85046648
14	MP0002837_dystrophic_cardiac_calcinosis	1.81175827
15	MP0009785_altered_susceptibility_to	1.75169608
16	MP0002163_abnormal_gland_morphology	1.74849062
17	MP0000372_irregular_coat_pigmentation	1.73121233
18	MP0002653_abnormal_ependyma_morphology	1.70350073
19	MP0005551_abnormal_eye_electrophysiolog	1.70278084
20	MP0005084_abnormal_gallbladder_morpholo	1.69265755
21	MP0002736_abnormal_nociception_after	1.68849100
22	MP0005646_abnormal_pituitary_gland	1.68138042
23	MP0002148_abnormal_hypersensitivity_rea	1.60045314
24	MP0002876_abnormal_thyroid_physiology	1.59817687
25	MP0001919_abnormal_reproductive_system	1.56310090
26	MP0001986_abnormal_taste_sensitivity	1.55326763
27	MP0001800_abnormal_humoral_immune	1.55316049
28	MP0004142_abnormal_muscle_tone	1.54710076
29	MP0002138_abnormal_hepatobiliary_system	1.53180620
30	MP0003011_delayed_dark_adaptation	1.52204466
31	MP0000685_abnormal_immune_system	1.52044371
32	MP0001905_abnormal_dopamine_level	1.51230217
33	MP0008058_abnormal_DNA_repair	1.45387369
34	MP0005253_abnormal_eye_physiology	1.42364662
35	MP0002166_altered_tumor_susceptibility	1.38217797
36	MP0005389_reproductive_system_phenotype	1.36224033
37	MP0004147_increased_porphyrin_level	1.34610243
38	MP0005075_abnormal_melanosome_morpholog	1.32835943
39	MP0005387_immune_system_phenotype	1.32213044
40	MP0001790_abnormal_immune_system	1.32213044
41	MP0004885_abnormal_endolymph	1.31514249
42	MP0005000_abnormal_immune_tolerance	1.29352432
43	MP0002277_abnormal_respiratory_mucosa	1.27888232
44	MP0005379_endocrine/exocrine_gland_phen	1.25784787
45	MP0002095_abnormal_skin_pigmentation	1.23839258
46	MP0002723_abnormal_immune_serum	1.23743771
47	MP0009333_abnormal_splenocyte_physiolog	1.23311628
48	MP0005174_abnormal_tail_pigmentation	1.22237153
49	MP0002638_abnormal_pupillary_reflex	1.21885619
50	MP0001485_abnormal_pinna_reflex	1.20054772
51	MP0003195_calcinosis	1.18525747
52	MP0002272_abnormal_nervous_system	1.18166006
53	MP0001529_abnormal_vocalization	1.18152001
54	MP0006276_abnormal_autonomic_nervous	1.16520308
55	MP0009764_decreased_sensitivity_to	1.15361403
56	MP0003866_abnormal_defecation	1.14237909
57	MP0008789_abnormal_olfactory_epithelium	1.13820950
58	MP0002420_abnormal_adaptive_immunity	1.13267503
59	MP0000631_abnormal_neuroendocrine_gland	1.12301950
60	MP0001819_abnormal_immune_cell	1.11362417
61	MP0002006_tumorigenesis	1.10897074
62	MP0003878_abnormal_ear_physiology	1.10049253
63	MP0005377_hearing/vestibular/ear_phenot	1.10049253
64	MP0003186_abnormal_redox_activity	1.08955971
65	MP0010386_abnormal_urinary_bladder	1.08452902
66	MP0004742_abnormal_vestibular_system	1.07898314
67	MP0003806_abnormal_nucleotide_metabolis	1.07827301
68	MP0003252_abnormal_bile_duct	1.05873979
69	MP0008775_abnormal_heart_ventricle	1.05302640
70	MP0002733_abnormal_thermal_nociception	1.05264972
71	MP0002452_abnormal_antigen_presenting	1.04086175
72	MP0001970_abnormal_pain_threshold	1.03961088
73	MP0008995_early_reproductive_senescence	1.03158969
74	MP0002735_abnormal_chemical_nociception	1.02204202
75	MP0005025_abnormal_response_to	0.98791662
76	MP0003787_abnormal_imprinting	0.98721572
77	MP0003786_premature_aging	0.96599117
78	MP0009745_abnormal_behavioral_response	0.95535278
79	MP0000569_abnormal_digit_pigmentation	0.95002811
80	MP0001873_stomach_inflammation	0.94096072
81	MP0001501_abnormal_sleep_pattern	0.90151698
82	MP0001440_abnormal_grooming_behavior	0.89421278
83	MP0006036_abnormal_mitochondrial_physio	0.88054504
84	MP0005085_abnormal_gallbladder_physiolo	0.84501774
85	MP0003136_yellow_coat_color	0.84139141
86	MP0002234_abnormal_pharynx_morphology	0.81640661
87	MP0005360_urolithiasis	0.81614052
88	MP0000716_abnormal_immune_system	0.81351921
89	MP0001984_abnormal_olfaction	0.80938084
90	MP0003880_abnormal_central_pattern	0.80915086
91	MP0005636_abnormal_mineral_homeostasis	0.80464909
92	MP0001845_abnormal_inflammatory_respons	0.80042491
93	MP0003724_increased_susceptibility_to	0.77594016
94	MP0004133_heterotaxia	0.77465557
95	MP0010155_abnormal_intestine_physiology	0.76324103
96	MP0002693_abnormal_pancreas_physiology	0.76074120
97	MP0002160_abnormal_reproductive_system	0.76019644
98	MP0006035_abnormal_mitochondrial_morpho	0.75518489
99	MP0003763_abnormal_thymus_physiology	0.73275886
100	MP0005195_abnormal_posterior_eye	0.73047627

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.05719230
2	Mitochondrial inheritance (HP:0001427)	3.91663390
3	Pancreatic cysts (HP:0001737)	3.64555779
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.58259609
5	Aplastic anemia (HP:0001915)	3.51294683
6	Progressive macrocephaly (HP:0004481)	3.50668150
7	Acute encephalopathy (HP:0006846)	3.43483254
8	Hepatocellular necrosis (HP:0001404)	3.38925688
9	Congenital stationary night blindness (HP:0007642)	3.38359066
10	Increased CSF lactate (HP:0002490)	3.37269700
11	Molar tooth sign on MRI (HP:0002419)	3.31430093
12	Abnormality of midbrain morphology (HP:0002418)	3.31430093
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.27758383
14	IgG deficiency (HP:0004315)	3.23222835
15	Pancreatic fibrosis (HP:0100732)	3.19355147
16	3-Methylglutaconic aciduria (HP:0003535)	3.10268757
17	Hepatic necrosis (HP:0002605)	3.03038659
18	Stomatitis (HP:0010280)	2.99799494
19	Methylmalonic acidemia (HP:0002912)	2.99644752
20	True hermaphroditism (HP:0010459)	2.96563235
21	Hypoproteinemia (HP:0003075)	2.92085424
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.79772139
23	Severe combined immunodeficiency (HP:0004430)	2.79157261
24	Increased hepatocellular lipid droplets (HP:0006565)	2.77085952
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.72572583
26	Lipid accumulation in hepatocytes (HP:0006561)	2.70276074
27	Methylmalonic aciduria (HP:0012120)	2.64826662
28	Reticulocytopenia (HP:0001896)	2.60168117
29	Cerebral edema (HP:0002181)	2.59372791
30	Nephronophthisis (HP:0000090)	2.59324427
31	Optic disc pallor (HP:0000543)	2.57614552
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56007998
33	Attenuation of retinal blood vessels (HP:0007843)	2.54230175
34	Thyroiditis (HP:0100646)	2.54053241
35	Abolished electroretinogram (ERG) (HP:0000550)	2.52395594
36	Decreased central vision (HP:0007663)	2.48400508
37	Type II lissencephaly (HP:0007260)	2.47074919
38	Renal Fanconi syndrome (HP:0001994)	2.38774138
39	Abnormality of B cell number (HP:0010975)	2.38659257
40	Pendular nystagmus (HP:0012043)	2.35343610
41	Abnormality of the renal cortex (HP:0011035)	2.32844180
42	Increased IgM level (HP:0003496)	2.30886985
43	Abnormality of the prostate (HP:0008775)	2.30570985
44	Increased serum lactate (HP:0002151)	2.25653405
45	Increased intramyocellular lipid droplets (HP:0012240)	2.24763769
46	Pancytopenia (HP:0001876)	2.22918512
47	Renal cortical cysts (HP:0000803)	2.22198200
48	Absent/shortened dynein arms (HP:0200106)	2.22007200
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22007200
50	Abnormality of cells of the erythroid lineage (HP:0012130)	2.19672551
51	Abnormality of T cell number (HP:0011839)	2.18282645
52	Abnormality of the renal medulla (HP:0100957)	2.14597894
53	Medial flaring of the eyebrow (HP:0010747)	2.11538666
54	Cystic liver disease (HP:0006706)	2.11039150
55	Abnormality of eosinophils (HP:0001879)	2.10257161
56	Lethargy (HP:0001254)	2.09645600
57	Lactic acidosis (HP:0003128)	2.09037206
58	Congenital, generalized hypertrichosis (HP:0004540)	2.06169777
59	Macrocytic anemia (HP:0001972)	2.01321228
60	Panhypogammaglobulinemia (HP:0003139)	2.00616156
61	Exertional dyspnea (HP:0002875)	1.99926053
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.99514595
63	Agitation (HP:0000713)	1.98376708
64	Increased corneal curvature (HP:0100692)	1.97854212
65	Keratoconus (HP:0000563)	1.97854212
66	Abnormal number of erythroid precursors (HP:0012131)	1.97557786
67	T lymphocytopenia (HP:0005403)	1.96920051
68	Eosinophilia (HP:0001880)	1.94583210
69	Type 2 muscle fiber atrophy (HP:0003554)	1.93396004
70	Abnormality of T cells (HP:0002843)	1.93138705
71	Combined immunodeficiency (HP:0005387)	1.91962881
72	Increased muscle lipid content (HP:0009058)	1.89597236
73	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.88927447
74	Respiratory failure (HP:0002878)	1.87708893
75	Sclerocornea (HP:0000647)	1.87433674
76	Absent thumb (HP:0009777)	1.87176300
77	Abnormal drinking behavior (HP:0030082)	1.85813888
78	Polydipsia (HP:0001959)	1.85813888
79	Ketosis (HP:0001946)	1.85632747
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84475699
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.84475699
82	Colon cancer (HP:0003003)	1.83350975
83	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81483445
84	B lymphocytopenia (HP:0010976)	1.81398774
85	Abnormality of vitamin B metabolism (HP:0004340)	1.80515479
86	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.80361596
87	Hypothermia (HP:0002045)	1.77804253
88	Asplenia (HP:0001746)	1.75848012
89	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74729253
90	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.73710306
91	Dicarboxylic aciduria (HP:0003215)	1.73710306
92	Pallor (HP:0000980)	1.72267441
93	Stomach cancer (HP:0012126)	1.72048475
94	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71005976
95	Hyperglycinemia (HP:0002154)	1.70989854
96	Abnormality of renal resorption (HP:0011038)	1.70076415
97	Type I transferrin isoform profile (HP:0003642)	1.67595565
98	Leukodystrophy (HP:0002415)	1.67164390
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.66796829
100	Constricted visual fields (HP:0001133)	1.66212686

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.51877942
2	TLK1	3.48828750
3	MAP4K2	3.41144134
4	ZAK	3.06656336
5	FRK	2.77511646
6	NUAK1	2.76915392
7	BCKDK	2.51429799
8	TAOK3	2.38856408
9	GRK1	2.34860204
10	ADRBK2	2.34309293
11	KDR	2.32485777
12	PINK1	2.22843783
13	VRK2	2.20580219
14	WNK4	1.99861733
15	VRK1	1.90347465
16	STK16	1.68912042
17	MST4	1.63363858
18	TEC	1.49166284
19	TIE1	1.44379934
20	FES	1.44031856
21	ITK	1.41539175
22	MAP4K1	1.36492187
23	DYRK2	1.36076394
24	WNK3	1.35455522
25	CDK19	1.35326931
26	MAP3K12	1.32347321
27	IKBKB	1.30908269
28	OXSR1	1.14813167
29	SYK	1.11623543
30	GRK7	1.08662393
31	PRKCQ	1.08220507
32	MAPK13	1.05360150
33	NME1	1.03222205
34	BMPR1B	1.01940573
35	CSNK1G3	0.99504021
36	EIF2AK3	0.97838225
37	CAMKK2	0.97472115
38	MAPKAPK3	0.94655391
39	TESK2	0.94520564
40	STK39	0.89675141
41	CSNK1G2	0.89540698
42	INSRR	0.88209624
43	BTK	0.88185423
44	GRK6	0.86567075
45	STK38L	0.82476821
46	MAPKAPK5	0.81887552
47	ADRBK1	0.78928512
48	AKT3	0.76433143
49	BMPR2	0.75798541
50	CSNK1G1	0.75124387
51	LCK	0.74831549
52	LYN	0.73679931
53	CSNK1A1L	0.72411273
54	MUSK	0.72222189
55	RPS6KA5	0.69478159
56	KIT	0.68815333
57	CSF1R	0.68623692
58	TNK2	0.67798433
59	MYLK	0.67736891
60	GRK5	0.65408526
61	IKBKE	0.63182379
62	PIK3CG	0.62946082
63	PAK3	0.62211543
64	DAPK1	0.61477820
65	PASK	0.59293829
66	MAP2K7	0.59105190
67	BRSK2	0.58050854
68	DAPK2	0.57262128
69	WNK1	0.57041592
70	MAP3K11	0.56313153
71	TRIM28	0.55938444
72	OBSCN	0.55889115
73	PDK2	0.54055269
74	PRKCE	0.53635132
75	PRKACA	0.52329923
76	PLK2	0.51130816
77	DAPK3	0.50841120
78	LIMK1	0.48773595
79	PHKG1	0.47466761
80	PHKG2	0.47466761
81	IGF1R	0.46865128
82	PIM1	0.42926240
83	EIF2AK1	0.41839418
84	PIK3CA	0.41835907
85	PLK3	0.40958892
86	PRKCA	0.39441287
87	CHUK	0.39338638
88	FLT3	0.37582771
89	PKN1	0.36959345
90	TAF1	0.36538063
91	CSNK2A2	0.36146841
92	MARK3	0.35293318
93	ABL2	0.33240793
94	CAMK1	0.33155003
95	AURKA	0.33120888
96	ROCK1	0.32885355
97	PRKCG	0.32633061
98	PRKG1	0.32543413
99	CAMK2A	0.32412530
100	ATR	0.32124221

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56457017
2	Ribosome_Homo sapiens_hsa03010	3.48642508
3	Proteasome_Homo sapiens_hsa03050	3.34866246
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.13481428
5	Parkinsons disease_Homo sapiens_hsa05012	2.89415744
6	Asthma_Homo sapiens_hsa05310	2.81124998
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.66345248
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.62415557
9	Allograft rejection_Homo sapiens_hsa05330	2.61446320
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.43725284
11	RNA polymerase_Homo sapiens_hsa03020	2.15027744
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10549836
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.08896657
14	Caffeine metabolism_Homo sapiens_hsa00232	1.99489224
15	Phototransduction_Homo sapiens_hsa04744	1.96653957
16	Protein export_Homo sapiens_hsa03060	1.95370916
17	Alzheimers disease_Homo sapiens_hsa05010	1.90832429
18	Huntingtons disease_Homo sapiens_hsa05016	1.83461763
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.75973121
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.72232988
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71143315
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68350602
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.64335464
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59295396
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.53041800
26	RNA degradation_Homo sapiens_hsa03018	1.38026367
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.37951340
28	Homologous recombination_Homo sapiens_hsa03440	1.37339997
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.28360677
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.24438156
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18990109
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.18127202
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16943428
34	Basal transcription factors_Homo sapiens_hsa03022	1.12646782
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12292605
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11890816
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.09089971
38	Peroxisome_Homo sapiens_hsa04146	1.08206220
39	Propanoate metabolism_Homo sapiens_hsa00640	1.00970514
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96237957
41	Sulfur metabolism_Homo sapiens_hsa00920	0.93735323
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93571210
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89838612
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88586761
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86229671
46	Regulation of autophagy_Homo sapiens_hsa04140	0.83043276
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81231184
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80730253
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80704713
50	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.80312087
51	Retinol metabolism_Homo sapiens_hsa00830	0.79603074
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79595494
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.79497442
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79300632
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78987928
56	Olfactory transduction_Homo sapiens_hsa04740	0.78555709
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77477508
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76784895
59	Viral myocarditis_Homo sapiens_hsa05416	0.75294232
60	Sulfur relay system_Homo sapiens_hsa04122	0.73382485
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73256747
62	Purine metabolism_Homo sapiens_hsa00230	0.72956412
63	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71129965
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.70740481
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67534196
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66947428
67	Nicotine addiction_Homo sapiens_hsa05033	0.66087814
68	Butanoate metabolism_Homo sapiens_hsa00650	0.66010182
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60739408
70	One carbon pool by folate_Homo sapiens_hsa00670	0.60128745
71	Metabolic pathways_Homo sapiens_hsa01100	0.55012016
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54592409
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53869114
74	Taste transduction_Homo sapiens_hsa04742	0.52299323
75	Mismatch repair_Homo sapiens_hsa03430	0.52050103
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.52004238
77	DNA replication_Homo sapiens_hsa03030	0.51746545
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51502937
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.51015221
80	Spliceosome_Homo sapiens_hsa03040	0.50400724
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47744060
82	Base excision repair_Homo sapiens_hsa03410	0.46288614
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45561784
84	Salivary secretion_Homo sapiens_hsa04970	0.45393091
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43847953
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38494831
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38466364
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.38252625
89	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.37772615
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35483773
91	RNA transport_Homo sapiens_hsa03013	0.35320463
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35004913
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33605286
94	Morphine addiction_Homo sapiens_hsa05032	0.31264997
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.30098992
96	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28272040
97	Glutathione metabolism_Homo sapiens_hsa00480	0.24486913
98	Fatty acid degradation_Homo sapiens_hsa00071	0.24439765
99	Mineral absorption_Homo sapiens_hsa04978	0.23896558
100	Herpes simplex infection_Homo sapiens_hsa05168	0.22329396

RPL13AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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