RPL13AP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.57010130
2viral transcription (GO:0019083)5.94822457
3translational termination (GO:0006415)5.69157343
4DNA deamination (GO:0045006)5.49403464
5behavioral response to nicotine (GO:0035095)5.25902045
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.15274080
7translational elongation (GO:0006414)5.06005429
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.85108222
9protein targeting to ER (GO:0045047)4.76845856
10cotranslational protein targeting to membrane (GO:0006613)4.76427893
11maturation of SSU-rRNA (GO:0030490)4.71587274
12ribosomal small subunit biogenesis (GO:0042274)4.66255785
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55793639
14protein localization to endoplasmic reticulum (GO:0070972)4.52925349
15viral life cycle (GO:0019058)4.23195045
16cytidine metabolic process (GO:0046087)4.19559410
17cytidine catabolic process (GO:0006216)4.19559410
18cytidine deamination (GO:0009972)4.19559410
19cellular protein complex disassembly (GO:0043624)4.18002321
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.05050453
21ATP synthesis coupled proton transport (GO:0015986)3.97149913
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.97149913
23negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.85417137
24translational initiation (GO:0006413)3.81667024
25protein complex biogenesis (GO:0070271)3.80228258
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79731554
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.79731554
28NADH dehydrogenase complex assembly (GO:0010257)3.79731554
29pyrimidine ribonucleoside catabolic process (GO:0046133)3.70413935
30chaperone-mediated protein transport (GO:0072321)3.64573291
31ubiquinone biosynthetic process (GO:0006744)3.63740396
32ribosomal large subunit biogenesis (GO:0042273)3.59377563
33piRNA metabolic process (GO:0034587)3.46352539
34protein complex disassembly (GO:0043241)3.41620073
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38422609
36mitochondrial respiratory chain complex assembly (GO:0033108)3.37677597
37translation (GO:0006412)3.36669011
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.36137102
39rRNA catabolic process (GO:0016075)3.26548510
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24223206
41ubiquinone metabolic process (GO:0006743)3.23897868
42macromolecular complex disassembly (GO:0032984)3.23187429
43protein neddylation (GO:0045116)3.21938446
44base-excision repair, AP site formation (GO:0006285)3.19776426
45water-soluble vitamin biosynthetic process (GO:0042364)3.18959334
46negative regulation of telomere maintenance (GO:0032205)3.17618073
47iron-sulfur cluster assembly (GO:0016226)3.12645644
48metallo-sulfur cluster assembly (GO:0031163)3.12645644
49protein targeting to membrane (GO:0006612)3.11979832
50positive regulation of defense response to virus by host (GO:0002230)3.00582577
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.00252166
52cellular component biogenesis (GO:0044085)3.00117060
53quinone biosynthetic process (GO:1901663)2.99846661
54negative regulation of DNA-templated transcription, elongation (GO:0032785)2.94956839
55preassembly of GPI anchor in ER membrane (GO:0016254)2.94892675
56cellular response to interleukin-15 (GO:0071350)2.88874127
57negative regulation of mast cell activation (GO:0033004)2.88142200
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87157114
59ribonucleoprotein complex biogenesis (GO:0022613)2.86302670
60mRNA catabolic process (GO:0006402)2.85931731
61electron transport chain (GO:0022900)2.83441080
62respiratory electron transport chain (GO:0022904)2.82331269
63response to pheromone (GO:0019236)2.81275051
64platelet dense granule organization (GO:0060155)2.80640476
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78123842
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78123842
67pseudouridine synthesis (GO:0001522)2.77462338
68fucose catabolic process (GO:0019317)2.76924947
69L-fucose metabolic process (GO:0042354)2.76924947
70L-fucose catabolic process (GO:0042355)2.76924947
71regulation of mitotic spindle checkpoint (GO:1903504)2.76869990
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76869990
73negative T cell selection (GO:0043383)2.74350119
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72308225
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71740513
76regulation of cilium movement (GO:0003352)2.69351956
77positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.67850581
78positive regulation of prostaglandin secretion (GO:0032308)2.67234534
79positive regulation of fatty acid transport (GO:2000193)2.65334674
80endoderm formation (GO:0001706)2.64553287
81mast cell degranulation (GO:0043303)2.64090990
82mast cell activation involved in immune response (GO:0002279)2.64090990
83DNA methylation involved in gamete generation (GO:0043046)2.63382918
84GTP biosynthetic process (GO:0006183)2.62823222
85RNA catabolic process (GO:0006401)2.60688933
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58805025
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.56592064
88termination of RNA polymerase III transcription (GO:0006386)2.56592064
89GPI anchor metabolic process (GO:0006505)2.52549915
90mannosylation (GO:0097502)2.49724683
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49183775
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46643532
93rRNA metabolic process (GO:0016072)2.44797560
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44446565
95sequestering of actin monomers (GO:0042989)2.44019265
96positive thymic T cell selection (GO:0045059)2.42334563
97GPI anchor biosynthetic process (GO:0006506)2.40837148
98interferon-gamma production (GO:0032609)2.40813266
99rRNA processing (GO:0006364)2.39710192
100regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.38999298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.55303972
2EZH2_22144423_ChIP-Seq_EOC_Human3.53661685
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49252302
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.43730351
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81906284
6VDR_22108803_ChIP-Seq_LS180_Human2.79038234
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68999286
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.65261950
9ZNF274_21170338_ChIP-Seq_K562_Hela2.59241688
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55950567
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.47587630
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39121599
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.25926024
14VDR_23849224_ChIP-Seq_CD4+_Human2.17723357
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12748539
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.07030216
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.98147892
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95883560
19IGF1R_20145208_ChIP-Seq_DFB_Human1.91920144
20MYC_18940864_ChIP-ChIP_HL60_Human1.90304855
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89576155
22FOXP3_21729870_ChIP-Seq_TREG_Human1.87180163
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71480492
24IRF1_19129219_ChIP-ChIP_H3396_Human1.69711678
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69506917
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63516220
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59942861
28TP53_22573176_ChIP-Seq_HFKS_Human1.59357616
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58944363
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.55099806
31NANOG_20526341_ChIP-Seq_ESCs_Human1.54544957
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50935605
33EWS_26573619_Chip-Seq_HEK293_Human1.47680263
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45185240
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44834336
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43895483
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43088206
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41204305
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40649982
40AR_20517297_ChIP-Seq_VCAP_Human1.37977718
41ERA_21632823_ChIP-Seq_H3396_Human1.37410233
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37054246
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.34845515
44GATA3_26560356_Chip-Seq_TH2_Human1.34259587
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33511630
46CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.32117843
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31763444
48NCOR_22424771_ChIP-Seq_293T_Human1.31110211
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30232443
50TAF2_19829295_ChIP-Seq_ESCs_Human1.27800146
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.26626966
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.26567905
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26567905
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.25995148
55BCL6_27268052_Chip-Seq_Bcells_Human1.25903285
56ELK1_19687146_ChIP-ChIP_HELA_Human1.25036305
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21780034
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.20840360
59MYC_19829295_ChIP-Seq_ESCs_Human1.19605637
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.18703190
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18213437
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18020536
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.14290371
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13591299
65RUNX_20019798_ChIP-Seq_JUKART_Human1.13221650
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12612495
67HOXB7_26014856_ChIP-Seq_BT474_Human1.11284048
68E2F1_20622854_ChIP-Seq_HELA_Human1.10261380
69TTF2_22483619_ChIP-Seq_HELA_Human1.09526590
70CTCF_20526341_ChIP-Seq_ESCs_Human1.08699820
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07219317
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06447275
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06402423
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.05263607
75ER_23166858_ChIP-Seq_MCF-7_Human1.04548309
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04356988
77P300_27268052_Chip-Seq_Bcells_Human1.04217851
78FOXH1_21741376_ChIP-Seq_ESCs_Human1.03122343
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03080602
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02854087
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02277343
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02138627
83P53_21459846_ChIP-Seq_SAOS-2_Human1.00355523
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00166209
85NANOG_19829295_ChIP-Seq_ESCs_Human1.00131281
86SOX2_19829295_ChIP-Seq_ESCs_Human1.00131281
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99843662
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.99607851
89OCT4_20526341_ChIP-Seq_ESCs_Human0.99560202
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98854020
91CBP_20019798_ChIP-Seq_JUKART_Human0.98176170
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98176170
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95189292
94STAT1_20625510_ChIP-Seq_HELA_Human0.92822156
95MYB_26560356_Chip-Seq_TH2_Human0.92398721
96CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92277676
97REST_21632747_ChIP-Seq_MESCs_Mouse0.91890721
98CIITA_25753668_ChIP-Seq_RAJI_Human0.91707871
99RAC3_21632823_ChIP-Seq_H3396_Human0.91353992
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91281938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.28706839
2MP0006292_abnormal_olfactory_placode3.68621757
3MP0005671_abnormal_response_to3.33143834
4MP0003646_muscle_fatigue2.97559397
5MP0008877_abnormal_DNA_methylation2.78909051
6MP0006072_abnormal_retinal_apoptosis2.42380082
7MP0002653_abnormal_ependyma_morphology1.97356797
8MP0002837_dystrophic_cardiac_calcinosis1.94336972
9MP0008872_abnormal_physiological_respon1.89773367
10MP0002102_abnormal_ear_morphology1.85976325
11MP0002138_abnormal_hepatobiliary_system1.85472608
12MP0004885_abnormal_endolymph1.78901269
13MP0004142_abnormal_muscle_tone1.78542644
14MP0003787_abnormal_imprinting1.78118418
15MP0004147_increased_porphyrin_level1.77478771
16MP0001968_abnormal_touch/_nociception1.77193093
17MP0002876_abnormal_thyroid_physiology1.76972925
18MP0004145_abnormal_muscle_electrophysio1.71190860
19MP0001986_abnormal_taste_sensitivity1.70105767
20MP0003763_abnormal_thymus_physiology1.66930870
21MP0000685_abnormal_immune_system1.64738023
22MP0005551_abnormal_eye_electrophysiolog1.61795572
23MP0002163_abnormal_gland_morphology1.60175966
24MP0008875_abnormal_xenobiotic_pharmacok1.58414977
25MP0008789_abnormal_olfactory_epithelium1.56066656
26MP0005645_abnormal_hypothalamus_physiol1.54588513
27MP0002736_abnormal_nociception_after1.53101103
28MP0001835_abnormal_antigen_presentation1.44006528
29MP0001800_abnormal_humoral_immune1.42646230
30MP0004742_abnormal_vestibular_system1.40650954
31MP0005377_hearing/vestibular/ear_phenot1.38781887
32MP0003878_abnormal_ear_physiology1.38781887
33MP0002638_abnormal_pupillary_reflex1.35087879
34MP0005646_abnormal_pituitary_gland1.31509896
35MP0005075_abnormal_melanosome_morpholog1.30511995
36MP0005389_reproductive_system_phenotype1.30106074
37MP0005000_abnormal_immune_tolerance1.27369338
38MP0003011_delayed_dark_adaptation1.27331262
39MP0005084_abnormal_gallbladder_morpholo1.26596741
40MP0002148_abnormal_hypersensitivity_rea1.26161674
41MP0005423_abnormal_somatic_nervous1.24454745
42MP0001790_abnormal_immune_system1.22427313
43MP0005387_immune_system_phenotype1.22427313
44MP0002272_abnormal_nervous_system1.22222285
45MP0008995_early_reproductive_senescence1.21525918
46MP0009333_abnormal_splenocyte_physiolog1.21242318
47MP0002723_abnormal_immune_serum1.19204712
48MP0005174_abnormal_tail_pigmentation1.19042820
49MP0006276_abnormal_autonomic_nervous1.15498296
50MP0005253_abnormal_eye_physiology1.15459691
51MP0001919_abnormal_reproductive_system1.14339882
52MP0001905_abnormal_dopamine_level1.14262383
53MP0002160_abnormal_reproductive_system1.14080678
54MP0009785_altered_susceptibility_to1.12866992
55MP0002095_abnormal_skin_pigmentation1.12408826
56MP0002420_abnormal_adaptive_immunity1.12160623
57MP0001819_abnormal_immune_cell1.10987075
58MP0008058_abnormal_DNA_repair1.10664396
59MP0002166_altered_tumor_susceptibility1.07615539
60MP0001293_anophthalmia1.06704731
61MP0001485_abnormal_pinna_reflex1.04718016
62MP0005360_urolithiasis1.04673755
63MP0001984_abnormal_olfaction1.01531119
64MP0002006_tumorigenesis0.98822625
65MP0009764_decreased_sensitivity_to0.98171569
66MP0003122_maternal_imprinting0.97052571
67MP0003121_genomic_imprinting0.96965439
68MP0005394_taste/olfaction_phenotype0.96941518
69MP0005499_abnormal_olfactory_system0.96941518
70MP0000049_abnormal_middle_ear0.96150714
71MP0002735_abnormal_chemical_nociception0.96016851
72MP0002234_abnormal_pharynx_morphology0.94116059
73MP0002277_abnormal_respiratory_mucosa0.93503616
74MP0002452_abnormal_antigen_presenting0.91677164
75MP0009745_abnormal_behavioral_response0.91109978
76MP0010386_abnormal_urinary_bladder0.90169372
77MP0001963_abnormal_hearing_physiology0.88593138
78MP0005410_abnormal_fertilization0.88124891
79MP0005025_abnormal_response_to0.87068975
80MP0003806_abnormal_nucleotide_metabolis0.86722328
81MP0004133_heterotaxia0.85905720
82MP0000372_irregular_coat_pigmentation0.84876508
83MP0005195_abnormal_posterior_eye0.84367535
84MP0001970_abnormal_pain_threshold0.84117058
85MP0000631_abnormal_neuroendocrine_gland0.83676071
86MP0001873_stomach_inflammation0.80467542
87MP0003136_yellow_coat_color0.80284948
88MP0003880_abnormal_central_pattern0.79929707
89MP0002210_abnormal_sex_determination0.79723534
90MP0000716_abnormal_immune_system0.79395597
91MP0005379_endocrine/exocrine_gland_phen0.79200418
92MP0003866_abnormal_defecation0.76853879
93MP0002733_abnormal_thermal_nociception0.75552787
94MP0001929_abnormal_gametogenesis0.75416282
95MP0001529_abnormal_vocalization0.75338144
96MP0000026_abnormal_inner_ear0.74775151
97MP0002398_abnormal_bone_marrow0.74009821
98MP0008775_abnormal_heart_ventricle0.72942724
99MP0000703_abnormal_thymus_morphology0.72526911
100MP0003786_premature_aging0.72466970

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.20357224
2Reticulocytopenia (HP:0001896)4.05380021
3Congenital stationary night blindness (HP:0007642)4.01457204
4IgG deficiency (HP:0004315)3.58811777
5Abnormality of cells of the erythroid lineage (HP:0012130)3.56727012
6Abnormal rod and cone electroretinograms (HP:0008323)3.50881814
7Mitochondrial inheritance (HP:0001427)3.48002109
8Acute necrotizing encephalopathy (HP:0006965)3.40298739
9Hepatocellular necrosis (HP:0001404)3.13873356
10Abnormality of midbrain morphology (HP:0002418)3.10857780
11Molar tooth sign on MRI (HP:0002419)3.10857780
12Increased CSF lactate (HP:0002490)3.06726737
13Abnormal mitochondria in muscle tissue (HP:0008316)3.05328263
14Elevated erythrocyte sedimentation rate (HP:0003565)2.97600810
15Abnormal number of erythroid precursors (HP:0012131)2.95456197
16Severe combined immunodeficiency (HP:0004430)2.95205792
17Pancreatic cysts (HP:0001737)2.87539311
18Type II lissencephaly (HP:0007260)2.85487036
19Acute encephalopathy (HP:0006846)2.85443200
20Pancreatic fibrosis (HP:0100732)2.80369971
21Macrocytic anemia (HP:0001972)2.80289565
22Aplasia/Hypoplasia of the spleen (HP:0010451)2.78345718
23Hepatic necrosis (HP:0002605)2.76465770
24Increased hepatocellular lipid droplets (HP:0006565)2.76332013
25Asplenia (HP:0001746)2.69656191
26Lipid accumulation in hepatocytes (HP:0006561)2.69602401
27Progressive macrocephaly (HP:0004481)2.67247949
28Increased intramyocellular lipid droplets (HP:0012240)2.57183347
29True hermaphroditism (HP:0010459)2.56933441
30Nephronophthisis (HP:0000090)2.55601076
31Absent thumb (HP:0009777)2.54387769
32Hyperglycinemia (HP:0002154)2.51032488
33Type 2 muscle fiber atrophy (HP:0003554)2.49873644
34Cerebral edema (HP:0002181)2.46830239
35Optic disc pallor (HP:0000543)2.46677672
36Constricted visual fields (HP:0001133)2.45378204
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45093627
38Abolished electroretinogram (ERG) (HP:0000550)2.40280729
39Abnormality of the renal cortex (HP:0011035)2.39261793
40Increased serum lactate (HP:0002151)2.34231412
41Stomatitis (HP:0010280)2.32908610
42Renal Fanconi syndrome (HP:0001994)2.30472335
43Pallor (HP:0000980)2.30050572
44Septo-optic dysplasia (HP:0100842)2.28973731
45Methylmalonic acidemia (HP:0002912)2.28061678
46Stenosis of the external auditory canal (HP:0000402)2.25715782
47Medial flaring of the eyebrow (HP:0010747)2.24789076
48Abnormality of the renal collecting system (HP:0004742)2.23245965
49Renal cortical cysts (HP:0000803)2.22263869
50Increased muscle lipid content (HP:0009058)2.21939250
51Methylmalonic aciduria (HP:0012120)2.21517048
52Thyroiditis (HP:0100646)2.20376955
53Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.19840476
54Pendular nystagmus (HP:0012043)2.19779202
55Panhypogammaglobulinemia (HP:0003139)2.18731434
56Abnormality of the phalanges of the 5th finger (HP:0004213)2.16741807
57Combined immunodeficiency (HP:0005387)2.16430362
58Abnormality of B cell number (HP:0010975)2.13868949
59Lactic acidosis (HP:0003128)2.12951218
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12436200
61Congenital, generalized hypertrichosis (HP:0004540)2.10889733
62Abnormality of the renal medulla (HP:0100957)2.10741364
63Muscle fiber atrophy (HP:0100295)2.10695717
64Abnormality of T cells (HP:0002843)2.07530128
65Abnormality of T cell number (HP:0011839)2.04042263
66Lethargy (HP:0001254)2.03878632
67T lymphocytopenia (HP:0005403)2.03128654
68Rib fusion (HP:0000902)2.02809467
69Absent/shortened dynein arms (HP:0200106)2.02480472
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.02480472
71Supernumerary spleens (HP:0009799)2.01586874
72Symphalangism affecting the phalanges of the hand (HP:0009773)1.99930008
73Hypoproteinemia (HP:0003075)1.99645528
743-Methylglutaconic aciduria (HP:0003535)1.97672789
75Attenuation of retinal blood vessels (HP:0007843)1.96531474
76Increased IgM level (HP:0003496)1.95285452
77Abnormality of DNA repair (HP:0003254)1.93429789
78Ketosis (HP:0001946)1.91737635
79Aplastic anemia (HP:0001915)1.91083034
80Prostate neoplasm (HP:0100787)1.89601354
81Pancytopenia (HP:0001876)1.89168020
82Sclerocornea (HP:0000647)1.87575955
83Parakeratosis (HP:0001036)1.87307221
84Polydipsia (HP:0001959)1.84759094
85Abnormal drinking behavior (HP:0030082)1.84759094
86Abnormality of eosinophils (HP:0001879)1.83738822
87Respiratory failure (HP:0002878)1.83597232
88Abnormality of the pons (HP:0007361)1.81840767
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81710318
90Abnormality of the prostate (HP:0008775)1.80481814
91Hypoplasia of the uterus (HP:0000013)1.80217402
92Abnormality of serine family amino acid metabolism (HP:0010894)1.78940458
93Abnormality of glycine metabolism (HP:0010895)1.78940458
94Polyuria (HP:0000103)1.77092467
95Decreased central vision (HP:0007663)1.76928555
96Hypoplasia of the pons (HP:0012110)1.76563672
97B lymphocytopenia (HP:0010976)1.75967633
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75059653
99Abnormality of urine glucose concentration (HP:0011016)1.73096525
100Glycosuria (HP:0003076)1.73096525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.92318738
2TXK3.90773894
3TESK23.41684673
4ZAK3.03944228
5MAP4K22.98228672
6TLK12.78247082
7PINK12.69439418
8ADRBK22.62667094
9TAOK32.58557450
10GRK12.58444773
11VRK22.28444055
12WNK42.18336815
13NUAK12.13469605
14MUSK2.12327126
15STK162.06562242
16CDK191.97957306
17GRK61.95401149
18MAP4K11.77257171
19TIE11.76791098
20KDR1.73796369
21FRK1.73252883
22TEC1.48830819
23DYRK21.48245108
24ITK1.45739536
25PASK1.42224958
26VRK11.41494824
27IKBKB1.35770057
28FES1.32641115
29PRKCQ1.20744492
30MAP2K21.16214419
31CAMKK21.15800154
32WNK31.13244091
33SYK1.11610336
34NME11.06773674
35KIT1.04207052
36MAP3K111.00938275
37STK390.95481471
38IKBKE0.95364944
39BTK0.93537035
40MAP3K130.86551916
41BMPR1B0.86053488
42MAPKAPK30.85775905
43OXSR10.83035036
44CAMKK10.81461164
45PIM10.76844494
46LCK0.74747757
47LIMK10.72697485
48MAPK130.70367523
49ADRBK10.69466864
50MAPKAPK50.68376454
51PIK3CA0.64263722
52LYN0.63947559
53INSRR0.62476636
54CASK0.60135330
55ACVR1B0.59470354
56OBSCN0.58897805
57PRKCG0.57127260
58NTRK20.57115615
59GRK70.56741871
60RPS6KA50.54823305
61MST40.54506831
62CAMK10.54491920
63MATK0.54286277
64MARK30.52716136
65TGFBR10.51523035
66AURKA0.48682994
67PRKACA0.47782511
68RPS6KA60.47592791
69PRKCD0.45842281
70DAPK30.43715742
71CSF1R0.43515606
72JAK30.42726806
73CSNK2A20.42593329
74PHKG20.42336870
75PHKG10.42336870
76TNK20.42131667
77PRKCH0.42109424
78MAP3K40.40200177
79PRKCA0.38628990
80IGF1R0.38442054
81MAPK150.36463139
82CSNK2A10.34889609
83LRRK20.33843033
84CSNK1G20.32802379
85CSK0.32263719
86TYRO30.32136223
87MAP2K60.32123063
88TBK10.30907493
89AURKB0.30730993
90ATR0.30399793
91EIF2AK30.29976114
92MAP3K140.29004491
93EIF2AK20.28987093
94SIK20.28793315
95DAPK10.28539475
96PLK10.28381018
97NEK20.27444304
98PLK40.26808867
99CSNK1A10.26605500
100PRKCE0.26505080

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.10881368
2Primary immunodeficiency_Homo sapiens_hsa053403.29491272
3Oxidative phosphorylation_Homo sapiens_hsa001903.18388820
4Parkinsons disease_Homo sapiens_hsa050122.52250487
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48332079
6RNA polymerase_Homo sapiens_hsa030202.41035357
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.29442779
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.10099960
9Proteasome_Homo sapiens_hsa030502.09009758
10Linoleic acid metabolism_Homo sapiens_hsa005912.08335689
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04807246
12Asthma_Homo sapiens_hsa053101.99614096
13Allograft rejection_Homo sapiens_hsa053301.93886146
14Phototransduction_Homo sapiens_hsa047441.89289938
15Cardiac muscle contraction_Homo sapiens_hsa042601.88220313
16Graft-versus-host disease_Homo sapiens_hsa053321.80217898
17Autoimmune thyroid disease_Homo sapiens_hsa053201.78994677
18Homologous recombination_Homo sapiens_hsa034401.66116569
19Huntingtons disease_Homo sapiens_hsa050161.64441450
20Protein export_Homo sapiens_hsa030601.62778106
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62572045
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57891507
23RNA degradation_Homo sapiens_hsa030181.57484913
24Alzheimers disease_Homo sapiens_hsa050101.57430492
25Type I diabetes mellitus_Homo sapiens_hsa049401.39787281
26Sulfur relay system_Homo sapiens_hsa041221.39262171
27Nitrogen metabolism_Homo sapiens_hsa009101.39007972
28Antigen processing and presentation_Homo sapiens_hsa046121.30426953
29Fanconi anemia pathway_Homo sapiens_hsa034601.29065725
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27851477
31Propanoate metabolism_Homo sapiens_hsa006401.25413824
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24662676
33Pyrimidine metabolism_Homo sapiens_hsa002401.24579043
34Basal transcription factors_Homo sapiens_hsa030221.24000213
35Caffeine metabolism_Homo sapiens_hsa002321.22476964
36Hematopoietic cell lineage_Homo sapiens_hsa046401.18226172
37Arachidonic acid metabolism_Homo sapiens_hsa005901.13353456
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10906078
39Chemical carcinogenesis_Homo sapiens_hsa052041.05670289
40Peroxisome_Homo sapiens_hsa041461.03801156
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98638948
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98336911
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97968782
44Retinol metabolism_Homo sapiens_hsa008300.96603840
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95832793
46Fat digestion and absorption_Homo sapiens_hsa049750.95763563
47Base excision repair_Homo sapiens_hsa034100.94597038
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94595474
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94029547
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93503782
51T cell receptor signaling pathway_Homo sapiens_hsa046600.89930876
52Purine metabolism_Homo sapiens_hsa002300.88566233
53Nicotine addiction_Homo sapiens_hsa050330.88086887
54Olfactory transduction_Homo sapiens_hsa047400.84274099
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84149036
56Nucleotide excision repair_Homo sapiens_hsa034200.83891597
57Tryptophan metabolism_Homo sapiens_hsa003800.82124419
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80494464
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79450636
60Ether lipid metabolism_Homo sapiens_hsa005650.78862655
61Rheumatoid arthritis_Homo sapiens_hsa053230.76477767
62Regulation of autophagy_Homo sapiens_hsa041400.76131894
63One carbon pool by folate_Homo sapiens_hsa006700.74442812
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.73896620
65Mismatch repair_Homo sapiens_hsa034300.73814120
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73500273
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70484015
68Taste transduction_Homo sapiens_hsa047420.70111897
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.66561912
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.65418248
71Sulfur metabolism_Homo sapiens_hsa009200.64848469
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64649233
73Metabolic pathways_Homo sapiens_hsa011000.63989331
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63847387
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.63480593
76Butanoate metabolism_Homo sapiens_hsa006500.63268894
77Spliceosome_Homo sapiens_hsa030400.62871694
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60632434
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58923810
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.58523478
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57512590
82DNA replication_Homo sapiens_hsa030300.53487560
83Selenocompound metabolism_Homo sapiens_hsa004500.47637406
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.45797266
85RNA transport_Homo sapiens_hsa030130.45718093
86Vitamin digestion and absorption_Homo sapiens_hsa049770.42821764
87Folate biosynthesis_Homo sapiens_hsa007900.41412256
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41016290
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.40583288
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39724450
91Morphine addiction_Homo sapiens_hsa050320.39400686
92beta-Alanine metabolism_Homo sapiens_hsa004100.38903159
93Glycerolipid metabolism_Homo sapiens_hsa005610.37589738
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37285097
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34835973
96Glutathione metabolism_Homo sapiens_hsa004800.33233183
97Collecting duct acid secretion_Homo sapiens_hsa049660.32796825
98Salivary secretion_Homo sapiens_hsa049700.32612751
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32314303
100Ovarian steroidogenesis_Homo sapiens_hsa049130.32012301

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