Rank | Gene Set | Z-score |
---|---|---|
1 | ribosomal small subunit assembly (GO:0000028) | 6.57010130 |
2 | viral transcription (GO:0019083) | 5.94822457 |
3 | translational termination (GO:0006415) | 5.69157343 |
4 | DNA deamination (GO:0045006) | 5.49403464 |
5 | behavioral response to nicotine (GO:0035095) | 5.25902045 |
6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.15274080 |
7 | translational elongation (GO:0006414) | 5.06005429 |
8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.85108222 |
9 | protein targeting to ER (GO:0045047) | 4.76845856 |
10 | cotranslational protein targeting to membrane (GO:0006613) | 4.76427893 |
11 | maturation of SSU-rRNA (GO:0030490) | 4.71587274 |
12 | ribosomal small subunit biogenesis (GO:0042274) | 4.66255785 |
13 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.55793639 |
14 | protein localization to endoplasmic reticulum (GO:0070972) | 4.52925349 |
15 | viral life cycle (GO:0019058) | 4.23195045 |
16 | cytidine metabolic process (GO:0046087) | 4.19559410 |
17 | cytidine catabolic process (GO:0006216) | 4.19559410 |
18 | cytidine deamination (GO:0009972) | 4.19559410 |
19 | cellular protein complex disassembly (GO:0043624) | 4.18002321 |
20 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.05050453 |
21 | ATP synthesis coupled proton transport (GO:0015986) | 3.97149913 |
22 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.97149913 |
23 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 3.85417137 |
24 | translational initiation (GO:0006413) | 3.81667024 |
25 | protein complex biogenesis (GO:0070271) | 3.80228258 |
26 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.79731554 |
27 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.79731554 |
28 | NADH dehydrogenase complex assembly (GO:0010257) | 3.79731554 |
29 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.70413935 |
30 | chaperone-mediated protein transport (GO:0072321) | 3.64573291 |
31 | ubiquinone biosynthetic process (GO:0006744) | 3.63740396 |
32 | ribosomal large subunit biogenesis (GO:0042273) | 3.59377563 |
33 | piRNA metabolic process (GO:0034587) | 3.46352539 |
34 | protein complex disassembly (GO:0043241) | 3.41620073 |
35 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.38422609 |
36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.37677597 |
37 | translation (GO:0006412) | 3.36669011 |
38 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.36137102 |
39 | rRNA catabolic process (GO:0016075) | 3.26548510 |
40 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.24223206 |
41 | ubiquinone metabolic process (GO:0006743) | 3.23897868 |
42 | macromolecular complex disassembly (GO:0032984) | 3.23187429 |
43 | protein neddylation (GO:0045116) | 3.21938446 |
44 | base-excision repair, AP site formation (GO:0006285) | 3.19776426 |
45 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.18959334 |
46 | negative regulation of telomere maintenance (GO:0032205) | 3.17618073 |
47 | iron-sulfur cluster assembly (GO:0016226) | 3.12645644 |
48 | metallo-sulfur cluster assembly (GO:0031163) | 3.12645644 |
49 | protein targeting to membrane (GO:0006612) | 3.11979832 |
50 | positive regulation of defense response to virus by host (GO:0002230) | 3.00582577 |
51 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.00252166 |
52 | cellular component biogenesis (GO:0044085) | 3.00117060 |
53 | quinone biosynthetic process (GO:1901663) | 2.99846661 |
54 | negative regulation of DNA-templated transcription, elongation (GO:0032785) | 2.94956839 |
55 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.94892675 |
56 | cellular response to interleukin-15 (GO:0071350) | 2.88874127 |
57 | negative regulation of mast cell activation (GO:0033004) | 2.88142200 |
58 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.87157114 |
59 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.86302670 |
60 | mRNA catabolic process (GO:0006402) | 2.85931731 |
61 | electron transport chain (GO:0022900) | 2.83441080 |
62 | respiratory electron transport chain (GO:0022904) | 2.82331269 |
63 | response to pheromone (GO:0019236) | 2.81275051 |
64 | platelet dense granule organization (GO:0060155) | 2.80640476 |
65 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.78123842 |
66 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.78123842 |
67 | pseudouridine synthesis (GO:0001522) | 2.77462338 |
68 | fucose catabolic process (GO:0019317) | 2.76924947 |
69 | L-fucose metabolic process (GO:0042354) | 2.76924947 |
70 | L-fucose catabolic process (GO:0042355) | 2.76924947 |
71 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.76869990 |
72 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.76869990 |
73 | negative T cell selection (GO:0043383) | 2.74350119 |
74 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.72308225 |
75 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.71740513 |
76 | regulation of cilium movement (GO:0003352) | 2.69351956 |
77 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 2.67850581 |
78 | positive regulation of prostaglandin secretion (GO:0032308) | 2.67234534 |
79 | positive regulation of fatty acid transport (GO:2000193) | 2.65334674 |
80 | endoderm formation (GO:0001706) | 2.64553287 |
81 | mast cell degranulation (GO:0043303) | 2.64090990 |
82 | mast cell activation involved in immune response (GO:0002279) | 2.64090990 |
83 | DNA methylation involved in gamete generation (GO:0043046) | 2.63382918 |
84 | GTP biosynthetic process (GO:0006183) | 2.62823222 |
85 | RNA catabolic process (GO:0006401) | 2.60688933 |
86 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.58805025 |
87 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.56592064 |
88 | termination of RNA polymerase III transcription (GO:0006386) | 2.56592064 |
89 | GPI anchor metabolic process (GO:0006505) | 2.52549915 |
90 | mannosylation (GO:0097502) | 2.49724683 |
91 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.49183775 |
92 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.46643532 |
93 | rRNA metabolic process (GO:0016072) | 2.44797560 |
94 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.44446565 |
95 | sequestering of actin monomers (GO:0042989) | 2.44019265 |
96 | positive thymic T cell selection (GO:0045059) | 2.42334563 |
97 | GPI anchor biosynthetic process (GO:0006506) | 2.40837148 |
98 | interferon-gamma production (GO:0032609) | 2.40813266 |
99 | rRNA processing (GO:0006364) | 2.39710192 |
100 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.38999298 |
Rank | Gene Set | Z-score |
---|---|---|
1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.55303972 |
2 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.53661685 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.49252302 |
4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.43730351 |
5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.81906284 |
6 | VDR_22108803_ChIP-Seq_LS180_Human | 2.79038234 |
7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.68999286 |
8 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.65261950 |
9 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.59241688 |
10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.55950567 |
11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.47587630 |
12 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.39121599 |
13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.25926024 |
14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.17723357 |
15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.12748539 |
16 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.07030216 |
17 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.98147892 |
18 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.95883560 |
19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.91920144 |
20 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.90304855 |
21 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.89576155 |
22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.87180163 |
23 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.71480492 |
24 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.69711678 |
25 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.69506917 |
26 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.63516220 |
27 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.59942861 |
28 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.59357616 |
29 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.58944363 |
30 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.55099806 |
31 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.54544957 |
32 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.50935605 |
33 | EWS_26573619_Chip-Seq_HEK293_Human | 1.47680263 |
34 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.45185240 |
35 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.44834336 |
36 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.43895483 |
37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.43088206 |
38 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.41204305 |
39 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.40649982 |
40 | AR_20517297_ChIP-Seq_VCAP_Human | 1.37977718 |
41 | ERA_21632823_ChIP-Seq_H3396_Human | 1.37410233 |
42 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37054246 |
43 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.34845515 |
44 | GATA3_26560356_Chip-Seq_TH2_Human | 1.34259587 |
45 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.33511630 |
46 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.32117843 |
47 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.31763444 |
48 | NCOR_22424771_ChIP-Seq_293T_Human | 1.31110211 |
49 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.30232443 |
50 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.27800146 |
51 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.26626966 |
52 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.26567905 |
53 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.26567905 |
54 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.25995148 |
55 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.25903285 |
56 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.25036305 |
57 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.21780034 |
58 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.20840360 |
59 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.19605637 |
60 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.18703190 |
61 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.18213437 |
62 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.18020536 |
63 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.14290371 |
64 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.13591299 |
65 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.13221650 |
66 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.12612495 |
67 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.11284048 |
68 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.10261380 |
69 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.09526590 |
70 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.08699820 |
71 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.07219317 |
72 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.06447275 |
73 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.06402423 |
74 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.05263607 |
75 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.04548309 |
76 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04356988 |
77 | P300_27268052_Chip-Seq_Bcells_Human | 1.04217851 |
78 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.03122343 |
79 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.03080602 |
80 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.02854087 |
81 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.02277343 |
82 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.02138627 |
83 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.00355523 |
84 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00166209 |
85 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.00131281 |
86 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.00131281 |
87 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.99843662 |
88 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.99607851 |
89 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.99560202 |
90 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.98854020 |
91 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.98176170 |
92 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.98176170 |
93 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.95189292 |
94 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.92822156 |
95 | MYB_26560356_Chip-Seq_TH2_Human | 0.92398721 |
96 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.92277676 |
97 | REST_21632747_ChIP-Seq_MESCs_Mouse | 0.91890721 |
98 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.91707871 |
99 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.91353992 |
100 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.91281938 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 4.28706839 |
2 | MP0006292_abnormal_olfactory_placode | 3.68621757 |
3 | MP0005671_abnormal_response_to | 3.33143834 |
4 | MP0003646_muscle_fatigue | 2.97559397 |
5 | MP0008877_abnormal_DNA_methylation | 2.78909051 |
6 | MP0006072_abnormal_retinal_apoptosis | 2.42380082 |
7 | MP0002653_abnormal_ependyma_morphology | 1.97356797 |
8 | MP0002837_dystrophic_cardiac_calcinosis | 1.94336972 |
9 | MP0008872_abnormal_physiological_respon | 1.89773367 |
10 | MP0002102_abnormal_ear_morphology | 1.85976325 |
11 | MP0002138_abnormal_hepatobiliary_system | 1.85472608 |
12 | MP0004885_abnormal_endolymph | 1.78901269 |
13 | MP0004142_abnormal_muscle_tone | 1.78542644 |
14 | MP0003787_abnormal_imprinting | 1.78118418 |
15 | MP0004147_increased_porphyrin_level | 1.77478771 |
16 | MP0001968_abnormal_touch/_nociception | 1.77193093 |
17 | MP0002876_abnormal_thyroid_physiology | 1.76972925 |
18 | MP0004145_abnormal_muscle_electrophysio | 1.71190860 |
19 | MP0001986_abnormal_taste_sensitivity | 1.70105767 |
20 | MP0003763_abnormal_thymus_physiology | 1.66930870 |
21 | MP0000685_abnormal_immune_system | 1.64738023 |
22 | MP0005551_abnormal_eye_electrophysiolog | 1.61795572 |
23 | MP0002163_abnormal_gland_morphology | 1.60175966 |
24 | MP0008875_abnormal_xenobiotic_pharmacok | 1.58414977 |
25 | MP0008789_abnormal_olfactory_epithelium | 1.56066656 |
26 | MP0005645_abnormal_hypothalamus_physiol | 1.54588513 |
27 | MP0002736_abnormal_nociception_after | 1.53101103 |
28 | MP0001835_abnormal_antigen_presentation | 1.44006528 |
29 | MP0001800_abnormal_humoral_immune | 1.42646230 |
30 | MP0004742_abnormal_vestibular_system | 1.40650954 |
31 | MP0005377_hearing/vestibular/ear_phenot | 1.38781887 |
32 | MP0003878_abnormal_ear_physiology | 1.38781887 |
33 | MP0002638_abnormal_pupillary_reflex | 1.35087879 |
34 | MP0005646_abnormal_pituitary_gland | 1.31509896 |
35 | MP0005075_abnormal_melanosome_morpholog | 1.30511995 |
36 | MP0005389_reproductive_system_phenotype | 1.30106074 |
37 | MP0005000_abnormal_immune_tolerance | 1.27369338 |
38 | MP0003011_delayed_dark_adaptation | 1.27331262 |
39 | MP0005084_abnormal_gallbladder_morpholo | 1.26596741 |
40 | MP0002148_abnormal_hypersensitivity_rea | 1.26161674 |
41 | MP0005423_abnormal_somatic_nervous | 1.24454745 |
42 | MP0001790_abnormal_immune_system | 1.22427313 |
43 | MP0005387_immune_system_phenotype | 1.22427313 |
44 | MP0002272_abnormal_nervous_system | 1.22222285 |
45 | MP0008995_early_reproductive_senescence | 1.21525918 |
46 | MP0009333_abnormal_splenocyte_physiolog | 1.21242318 |
47 | MP0002723_abnormal_immune_serum | 1.19204712 |
48 | MP0005174_abnormal_tail_pigmentation | 1.19042820 |
49 | MP0006276_abnormal_autonomic_nervous | 1.15498296 |
50 | MP0005253_abnormal_eye_physiology | 1.15459691 |
51 | MP0001919_abnormal_reproductive_system | 1.14339882 |
52 | MP0001905_abnormal_dopamine_level | 1.14262383 |
53 | MP0002160_abnormal_reproductive_system | 1.14080678 |
54 | MP0009785_altered_susceptibility_to | 1.12866992 |
55 | MP0002095_abnormal_skin_pigmentation | 1.12408826 |
56 | MP0002420_abnormal_adaptive_immunity | 1.12160623 |
57 | MP0001819_abnormal_immune_cell | 1.10987075 |
58 | MP0008058_abnormal_DNA_repair | 1.10664396 |
59 | MP0002166_altered_tumor_susceptibility | 1.07615539 |
60 | MP0001293_anophthalmia | 1.06704731 |
61 | MP0001485_abnormal_pinna_reflex | 1.04718016 |
62 | MP0005360_urolithiasis | 1.04673755 |
63 | MP0001984_abnormal_olfaction | 1.01531119 |
64 | MP0002006_tumorigenesis | 0.98822625 |
65 | MP0009764_decreased_sensitivity_to | 0.98171569 |
66 | MP0003122_maternal_imprinting | 0.97052571 |
67 | MP0003121_genomic_imprinting | 0.96965439 |
68 | MP0005394_taste/olfaction_phenotype | 0.96941518 |
69 | MP0005499_abnormal_olfactory_system | 0.96941518 |
70 | MP0000049_abnormal_middle_ear | 0.96150714 |
71 | MP0002735_abnormal_chemical_nociception | 0.96016851 |
72 | MP0002234_abnormal_pharynx_morphology | 0.94116059 |
73 | MP0002277_abnormal_respiratory_mucosa | 0.93503616 |
74 | MP0002452_abnormal_antigen_presenting | 0.91677164 |
75 | MP0009745_abnormal_behavioral_response | 0.91109978 |
76 | MP0010386_abnormal_urinary_bladder | 0.90169372 |
77 | MP0001963_abnormal_hearing_physiology | 0.88593138 |
78 | MP0005410_abnormal_fertilization | 0.88124891 |
79 | MP0005025_abnormal_response_to | 0.87068975 |
80 | MP0003806_abnormal_nucleotide_metabolis | 0.86722328 |
81 | MP0004133_heterotaxia | 0.85905720 |
82 | MP0000372_irregular_coat_pigmentation | 0.84876508 |
83 | MP0005195_abnormal_posterior_eye | 0.84367535 |
84 | MP0001970_abnormal_pain_threshold | 0.84117058 |
85 | MP0000631_abnormal_neuroendocrine_gland | 0.83676071 |
86 | MP0001873_stomach_inflammation | 0.80467542 |
87 | MP0003136_yellow_coat_color | 0.80284948 |
88 | MP0003880_abnormal_central_pattern | 0.79929707 |
89 | MP0002210_abnormal_sex_determination | 0.79723534 |
90 | MP0000716_abnormal_immune_system | 0.79395597 |
91 | MP0005379_endocrine/exocrine_gland_phen | 0.79200418 |
92 | MP0003866_abnormal_defecation | 0.76853879 |
93 | MP0002733_abnormal_thermal_nociception | 0.75552787 |
94 | MP0001929_abnormal_gametogenesis | 0.75416282 |
95 | MP0001529_abnormal_vocalization | 0.75338144 |
96 | MP0000026_abnormal_inner_ear | 0.74775151 |
97 | MP0002398_abnormal_bone_marrow | 0.74009821 |
98 | MP0008775_abnormal_heart_ventricle | 0.72942724 |
99 | MP0000703_abnormal_thymus_morphology | 0.72526911 |
100 | MP0003786_premature_aging | 0.72466970 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 4.20357224 |
2 | Reticulocytopenia (HP:0001896) | 4.05380021 |
3 | Congenital stationary night blindness (HP:0007642) | 4.01457204 |
4 | IgG deficiency (HP:0004315) | 3.58811777 |
5 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.56727012 |
6 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.50881814 |
7 | Mitochondrial inheritance (HP:0001427) | 3.48002109 |
8 | Acute necrotizing encephalopathy (HP:0006965) | 3.40298739 |
9 | Hepatocellular necrosis (HP:0001404) | 3.13873356 |
10 | Abnormality of midbrain morphology (HP:0002418) | 3.10857780 |
11 | Molar tooth sign on MRI (HP:0002419) | 3.10857780 |
12 | Increased CSF lactate (HP:0002490) | 3.06726737 |
13 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.05328263 |
14 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.97600810 |
15 | Abnormal number of erythroid precursors (HP:0012131) | 2.95456197 |
16 | Severe combined immunodeficiency (HP:0004430) | 2.95205792 |
17 | Pancreatic cysts (HP:0001737) | 2.87539311 |
18 | Type II lissencephaly (HP:0007260) | 2.85487036 |
19 | Acute encephalopathy (HP:0006846) | 2.85443200 |
20 | Pancreatic fibrosis (HP:0100732) | 2.80369971 |
21 | Macrocytic anemia (HP:0001972) | 2.80289565 |
22 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.78345718 |
23 | Hepatic necrosis (HP:0002605) | 2.76465770 |
24 | Increased hepatocellular lipid droplets (HP:0006565) | 2.76332013 |
25 | Asplenia (HP:0001746) | 2.69656191 |
26 | Lipid accumulation in hepatocytes (HP:0006561) | 2.69602401 |
27 | Progressive macrocephaly (HP:0004481) | 2.67247949 |
28 | Increased intramyocellular lipid droplets (HP:0012240) | 2.57183347 |
29 | True hermaphroditism (HP:0010459) | 2.56933441 |
30 | Nephronophthisis (HP:0000090) | 2.55601076 |
31 | Absent thumb (HP:0009777) | 2.54387769 |
32 | Hyperglycinemia (HP:0002154) | 2.51032488 |
33 | Type 2 muscle fiber atrophy (HP:0003554) | 2.49873644 |
34 | Cerebral edema (HP:0002181) | 2.46830239 |
35 | Optic disc pallor (HP:0000543) | 2.46677672 |
36 | Constricted visual fields (HP:0001133) | 2.45378204 |
37 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.45093627 |
38 | Abolished electroretinogram (ERG) (HP:0000550) | 2.40280729 |
39 | Abnormality of the renal cortex (HP:0011035) | 2.39261793 |
40 | Increased serum lactate (HP:0002151) | 2.34231412 |
41 | Stomatitis (HP:0010280) | 2.32908610 |
42 | Renal Fanconi syndrome (HP:0001994) | 2.30472335 |
43 | Pallor (HP:0000980) | 2.30050572 |
44 | Septo-optic dysplasia (HP:0100842) | 2.28973731 |
45 | Methylmalonic acidemia (HP:0002912) | 2.28061678 |
46 | Stenosis of the external auditory canal (HP:0000402) | 2.25715782 |
47 | Medial flaring of the eyebrow (HP:0010747) | 2.24789076 |
48 | Abnormality of the renal collecting system (HP:0004742) | 2.23245965 |
49 | Renal cortical cysts (HP:0000803) | 2.22263869 |
50 | Increased muscle lipid content (HP:0009058) | 2.21939250 |
51 | Methylmalonic aciduria (HP:0012120) | 2.21517048 |
52 | Thyroiditis (HP:0100646) | 2.20376955 |
53 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.19840476 |
54 | Pendular nystagmus (HP:0012043) | 2.19779202 |
55 | Panhypogammaglobulinemia (HP:0003139) | 2.18731434 |
56 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.16741807 |
57 | Combined immunodeficiency (HP:0005387) | 2.16430362 |
58 | Abnormality of B cell number (HP:0010975) | 2.13868949 |
59 | Lactic acidosis (HP:0003128) | 2.12951218 |
60 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.12436200 |
61 | Congenital, generalized hypertrichosis (HP:0004540) | 2.10889733 |
62 | Abnormality of the renal medulla (HP:0100957) | 2.10741364 |
63 | Muscle fiber atrophy (HP:0100295) | 2.10695717 |
64 | Abnormality of T cells (HP:0002843) | 2.07530128 |
65 | Abnormality of T cell number (HP:0011839) | 2.04042263 |
66 | Lethargy (HP:0001254) | 2.03878632 |
67 | T lymphocytopenia (HP:0005403) | 2.03128654 |
68 | Rib fusion (HP:0000902) | 2.02809467 |
69 | Absent/shortened dynein arms (HP:0200106) | 2.02480472 |
70 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.02480472 |
71 | Supernumerary spleens (HP:0009799) | 2.01586874 |
72 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.99930008 |
73 | Hypoproteinemia (HP:0003075) | 1.99645528 |
74 | 3-Methylglutaconic aciduria (HP:0003535) | 1.97672789 |
75 | Attenuation of retinal blood vessels (HP:0007843) | 1.96531474 |
76 | Increased IgM level (HP:0003496) | 1.95285452 |
77 | Abnormality of DNA repair (HP:0003254) | 1.93429789 |
78 | Ketosis (HP:0001946) | 1.91737635 |
79 | Aplastic anemia (HP:0001915) | 1.91083034 |
80 | Prostate neoplasm (HP:0100787) | 1.89601354 |
81 | Pancytopenia (HP:0001876) | 1.89168020 |
82 | Sclerocornea (HP:0000647) | 1.87575955 |
83 | Parakeratosis (HP:0001036) | 1.87307221 |
84 | Polydipsia (HP:0001959) | 1.84759094 |
85 | Abnormal drinking behavior (HP:0030082) | 1.84759094 |
86 | Abnormality of eosinophils (HP:0001879) | 1.83738822 |
87 | Respiratory failure (HP:0002878) | 1.83597232 |
88 | Abnormality of the pons (HP:0007361) | 1.81840767 |
89 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.81710318 |
90 | Abnormality of the prostate (HP:0008775) | 1.80481814 |
91 | Hypoplasia of the uterus (HP:0000013) | 1.80217402 |
92 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.78940458 |
93 | Abnormality of glycine metabolism (HP:0010895) | 1.78940458 |
94 | Polyuria (HP:0000103) | 1.77092467 |
95 | Decreased central vision (HP:0007663) | 1.76928555 |
96 | Hypoplasia of the pons (HP:0012110) | 1.76563672 |
97 | B lymphocytopenia (HP:0010976) | 1.75967633 |
98 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.75059653 |
99 | Abnormality of urine glucose concentration (HP:0011016) | 1.73096525 |
100 | Glycosuria (HP:0003076) | 1.73096525 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 3.92318738 |
2 | TXK | 3.90773894 |
3 | TESK2 | 3.41684673 |
4 | ZAK | 3.03944228 |
5 | MAP4K2 | 2.98228672 |
6 | TLK1 | 2.78247082 |
7 | PINK1 | 2.69439418 |
8 | ADRBK2 | 2.62667094 |
9 | TAOK3 | 2.58557450 |
10 | GRK1 | 2.58444773 |
11 | VRK2 | 2.28444055 |
12 | WNK4 | 2.18336815 |
13 | NUAK1 | 2.13469605 |
14 | MUSK | 2.12327126 |
15 | STK16 | 2.06562242 |
16 | CDK19 | 1.97957306 |
17 | GRK6 | 1.95401149 |
18 | MAP4K1 | 1.77257171 |
19 | TIE1 | 1.76791098 |
20 | KDR | 1.73796369 |
21 | FRK | 1.73252883 |
22 | TEC | 1.48830819 |
23 | DYRK2 | 1.48245108 |
24 | ITK | 1.45739536 |
25 | PASK | 1.42224958 |
26 | VRK1 | 1.41494824 |
27 | IKBKB | 1.35770057 |
28 | FES | 1.32641115 |
29 | PRKCQ | 1.20744492 |
30 | MAP2K2 | 1.16214419 |
31 | CAMKK2 | 1.15800154 |
32 | WNK3 | 1.13244091 |
33 | SYK | 1.11610336 |
34 | NME1 | 1.06773674 |
35 | KIT | 1.04207052 |
36 | MAP3K11 | 1.00938275 |
37 | STK39 | 0.95481471 |
38 | IKBKE | 0.95364944 |
39 | BTK | 0.93537035 |
40 | MAP3K13 | 0.86551916 |
41 | BMPR1B | 0.86053488 |
42 | MAPKAPK3 | 0.85775905 |
43 | OXSR1 | 0.83035036 |
44 | CAMKK1 | 0.81461164 |
45 | PIM1 | 0.76844494 |
46 | LCK | 0.74747757 |
47 | LIMK1 | 0.72697485 |
48 | MAPK13 | 0.70367523 |
49 | ADRBK1 | 0.69466864 |
50 | MAPKAPK5 | 0.68376454 |
51 | PIK3CA | 0.64263722 |
52 | LYN | 0.63947559 |
53 | INSRR | 0.62476636 |
54 | CASK | 0.60135330 |
55 | ACVR1B | 0.59470354 |
56 | OBSCN | 0.58897805 |
57 | PRKCG | 0.57127260 |
58 | NTRK2 | 0.57115615 |
59 | GRK7 | 0.56741871 |
60 | RPS6KA5 | 0.54823305 |
61 | MST4 | 0.54506831 |
62 | CAMK1 | 0.54491920 |
63 | MATK | 0.54286277 |
64 | MARK3 | 0.52716136 |
65 | TGFBR1 | 0.51523035 |
66 | AURKA | 0.48682994 |
67 | PRKACA | 0.47782511 |
68 | RPS6KA6 | 0.47592791 |
69 | PRKCD | 0.45842281 |
70 | DAPK3 | 0.43715742 |
71 | CSF1R | 0.43515606 |
72 | JAK3 | 0.42726806 |
73 | CSNK2A2 | 0.42593329 |
74 | PHKG2 | 0.42336870 |
75 | PHKG1 | 0.42336870 |
76 | TNK2 | 0.42131667 |
77 | PRKCH | 0.42109424 |
78 | MAP3K4 | 0.40200177 |
79 | PRKCA | 0.38628990 |
80 | IGF1R | 0.38442054 |
81 | MAPK15 | 0.36463139 |
82 | CSNK2A1 | 0.34889609 |
83 | LRRK2 | 0.33843033 |
84 | CSNK1G2 | 0.32802379 |
85 | CSK | 0.32263719 |
86 | TYRO3 | 0.32136223 |
87 | MAP2K6 | 0.32123063 |
88 | TBK1 | 0.30907493 |
89 | AURKB | 0.30730993 |
90 | ATR | 0.30399793 |
91 | EIF2AK3 | 0.29976114 |
92 | MAP3K14 | 0.29004491 |
93 | EIF2AK2 | 0.28987093 |
94 | SIK2 | 0.28793315 |
95 | DAPK1 | 0.28539475 |
96 | PLK1 | 0.28381018 |
97 | NEK2 | 0.27444304 |
98 | PLK4 | 0.26808867 |
99 | CSNK1A1 | 0.26605500 |
100 | PRKCE | 0.26505080 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 5.10881368 |
2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.29491272 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.18388820 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.52250487 |
5 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.48332079 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 2.41035357 |
7 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.29442779 |
8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.10099960 |
9 | Proteasome_Homo sapiens_hsa03050 | 2.09009758 |
10 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.08335689 |
11 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 2.04807246 |
12 | Asthma_Homo sapiens_hsa05310 | 1.99614096 |
13 | Allograft rejection_Homo sapiens_hsa05330 | 1.93886146 |
14 | Phototransduction_Homo sapiens_hsa04744 | 1.89289938 |
15 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.88220313 |
16 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.80217898 |
17 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.78994677 |
18 | Homologous recombination_Homo sapiens_hsa03440 | 1.66116569 |
19 | Huntingtons disease_Homo sapiens_hsa05016 | 1.64441450 |
20 | Protein export_Homo sapiens_hsa03060 | 1.62778106 |
21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.62572045 |
22 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.57891507 |
23 | RNA degradation_Homo sapiens_hsa03018 | 1.57484913 |
24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.57430492 |
25 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.39787281 |
26 | Sulfur relay system_Homo sapiens_hsa04122 | 1.39262171 |
27 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.39007972 |
28 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.30426953 |
29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.29065725 |
30 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.27851477 |
31 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.25413824 |
32 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.24662676 |
33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.24579043 |
34 | Basal transcription factors_Homo sapiens_hsa03022 | 1.24000213 |
35 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.22476964 |
36 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.18226172 |
37 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.13353456 |
38 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.10906078 |
39 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.05670289 |
40 | Peroxisome_Homo sapiens_hsa04146 | 1.03801156 |
41 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.98638948 |
42 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.98336911 |
43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97968782 |
44 | Retinol metabolism_Homo sapiens_hsa00830 | 0.96603840 |
45 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.95832793 |
46 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.95763563 |
47 | Base excision repair_Homo sapiens_hsa03410 | 0.94597038 |
48 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.94595474 |
49 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.94029547 |
50 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.93503782 |
51 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.89930876 |
52 | Purine metabolism_Homo sapiens_hsa00230 | 0.88566233 |
53 | Nicotine addiction_Homo sapiens_hsa05033 | 0.88086887 |
54 | Olfactory transduction_Homo sapiens_hsa04740 | 0.84274099 |
55 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.84149036 |
56 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.83891597 |
57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.82124419 |
58 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.80494464 |
59 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.79450636 |
60 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.78862655 |
61 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.76477767 |
62 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.76131894 |
63 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.74442812 |
64 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.73896620 |
65 | Mismatch repair_Homo sapiens_hsa03430 | 0.73814120 |
66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.73500273 |
67 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.70484015 |
68 | Taste transduction_Homo sapiens_hsa04742 | 0.70111897 |
69 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.66561912 |
70 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.65418248 |
71 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.64848469 |
72 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.64649233 |
73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.63989331 |
74 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.63847387 |
75 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.63480593 |
76 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.63268894 |
77 | Spliceosome_Homo sapiens_hsa03040 | 0.62871694 |
78 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.60632434 |
79 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.58923810 |
80 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.58523478 |
81 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.57512590 |
82 | DNA replication_Homo sapiens_hsa03030 | 0.53487560 |
83 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.47637406 |
84 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.45797266 |
85 | RNA transport_Homo sapiens_hsa03013 | 0.45718093 |
86 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.42821764 |
87 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41412256 |
88 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.41016290 |
89 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.40583288 |
90 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.39724450 |
91 | Morphine addiction_Homo sapiens_hsa05032 | 0.39400686 |
92 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.38903159 |
93 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37589738 |
94 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.37285097 |
95 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.34835973 |
96 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.33233183 |
97 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.32796825 |
98 | Salivary secretion_Homo sapiens_hsa04970 | 0.32612751 |
99 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.32314303 |
100 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.32012301 |