RPL13P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.49492657
2viral transcription (GO:0019083)5.99181491
3translational termination (GO:0006415)5.56173880
4translational elongation (GO:0006414)5.08256308
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.78316370
6ribosomal small subunit biogenesis (GO:0042274)4.76188474
7protein targeting to ER (GO:0045047)4.69564784
8cotranslational protein targeting to membrane (GO:0006613)4.65364636
9DNA deamination (GO:0045006)4.62459483
10positive thymic T cell selection (GO:0045059)4.57285704
11protein localization to endoplasmic reticulum (GO:0070972)4.44768310
12viral life cycle (GO:0019058)4.44444714
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42194095
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.41442107
15maturation of SSU-rRNA (GO:0030490)4.37409575
16cytidine deamination (GO:0009972)4.33240389
17cytidine metabolic process (GO:0046087)4.33240389
18cytidine catabolic process (GO:0006216)4.33240389
19antigen processing and presentation of endogenous antigen (GO:0019883)4.29562258
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.22705944
21negative T cell selection (GO:0043383)4.21175054
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.17563042
23cellular protein complex disassembly (GO:0043624)4.11119256
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.06365106
25thymic T cell selection (GO:0045061)4.04737820
26positive T cell selection (GO:0043368)4.00078107
27negative thymic T cell selection (GO:0045060)3.96367538
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95417997
29positive regulation of gamma-delta T cell activation (GO:0046645)3.87773922
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.77589219
31translational initiation (GO:0006413)3.76639457
32pyrimidine ribonucleoside catabolic process (GO:0046133)3.71175569
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.65101627
34T cell selection (GO:0045058)3.60933562
35regulation of B cell receptor signaling pathway (GO:0050855)3.58616688
36negative regulation of cell killing (GO:0031342)3.56211125
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56211125
38regulation of T cell mediated cytotoxicity (GO:0001914)3.51288602
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.49234222
40cellular response to interleukin-15 (GO:0071350)3.47776038
41response to interferon-beta (GO:0035456)3.46528716
42protein complex disassembly (GO:0043241)3.44531526
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43125649
44immunoglobulin mediated immune response (GO:0016064)3.42412409
45T cell costimulation (GO:0031295)3.41294483
46lymphocyte costimulation (GO:0031294)3.37746836
47regulation of gamma-delta T cell differentiation (GO:0045586)3.34173144
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.33663818
49regulation of alpha-beta T cell proliferation (GO:0046640)3.31764586
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26649469
51T cell receptor signaling pathway (GO:0050852)3.25998819
52purine deoxyribonucleotide catabolic process (GO:0009155)3.23621980
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.22384344
54regulation of natural killer cell mediated immunity (GO:0002715)3.19244442
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.19244442
56macromolecular complex disassembly (GO:0032984)3.18608748
57regulation of leukocyte mediated cytotoxicity (GO:0001910)3.16163004
58NIK/NF-kappaB signaling (GO:0038061)3.16162251
59tolerance induction (GO:0002507)3.14864129
60protein targeting to membrane (GO:0006612)3.14278210
61positive regulation of cell killing (GO:0031343)3.12517499
62regulation of gamma-delta T cell activation (GO:0046643)3.12453390
63positive regulation of B cell differentiation (GO:0045579)3.09725429
64antigen receptor-mediated signaling pathway (GO:0050851)3.08297456
65translation (GO:0006412)3.08241201
66T cell migration (GO:0072678)3.04170704
67cellular response to interferon-beta (GO:0035458)2.95647161
68response to interleukin-15 (GO:0070672)2.95475418
69regulation of regulatory T cell differentiation (GO:0045589)2.95384927
70iron-sulfur cluster assembly (GO:0016226)2.94957189
71metallo-sulfur cluster assembly (GO:0031163)2.94957189
72nuclear-transcribed mRNA catabolic process (GO:0000956)2.93800274
73regulation of cell killing (GO:0031341)2.93469053
74regulation of antigen processing and presentation (GO:0002577)2.92459221
75regulation of T cell tolerance induction (GO:0002664)2.91051253
76negative regulation of phagocytosis (GO:0050765)2.90946812
77regulation of interleukin-2 biosynthetic process (GO:0045076)2.83471983
78positive regulation of antigen processing and presentation (GO:0002579)2.83182656
79positive regulation of natural killer cell mediated immunity (GO:0002717)2.82802898
80positive regulation of calcium-mediated signaling (GO:0050850)2.80232799
81actin nucleation (GO:0045010)2.79073604
82regulation of B cell differentiation (GO:0045577)2.78807342
83mRNA catabolic process (GO:0006402)2.77985631
84B cell mediated immunity (GO:0019724)2.72596370
85positive regulation of prostaglandin secretion (GO:0032308)2.70817909
86ribosomal large subunit biogenesis (GO:0042273)2.69783617
87deoxyribonucleotide catabolic process (GO:0009264)2.67936446
88mast cell activation (GO:0045576)2.67656702
89energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67292081
90ATP synthesis coupled proton transport (GO:0015986)2.67292081
91GDP-mannose metabolic process (GO:0019673)2.61343556
92positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.60126747
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59335114
94myeloid dendritic cell activation (GO:0001773)2.59031873
95positive regulation of T cell mediated immunity (GO:0002711)2.58154234
96regulation of isotype switching to IgG isotypes (GO:0048302)2.57273853
97base-excision repair, AP site formation (GO:0006285)2.57215474
98deoxyribose phosphate catabolic process (GO:0046386)2.56251087
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56087672
100positive regulation of T cell migration (GO:2000406)2.55024215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.21456670
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.51579381
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.32557996
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.17812703
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10869790
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71747949
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55077640
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54215521
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48451750
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39515178
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.32589601
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29593102
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18755761
14MYC_22102868_ChIP-Seq_BL_Human2.14960294
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14201574
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13470142
17VDR_21846776_ChIP-Seq_THP-1_Human2.10698834
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.09858692
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08744382
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.07868546
21MYB_26560356_Chip-Seq_TH2_Human2.07004041
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04648036
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00560670
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97042875
25CIITA_25753668_ChIP-Seq_RAJI_Human1.93939896
26VDR_23849224_ChIP-Seq_CD4+_Human1.92579092
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91600012
28UTX_26944678_Chip-Seq_JUKART_Human1.90889764
29FOXP3_21729870_ChIP-Seq_TREG_Human1.87348376
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.85255496
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.82683588
32MAF_26560356_Chip-Seq_TH1_Human1.82583908
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81579888
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81073206
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79409145
36MAF_26560356_Chip-Seq_TH2_Human1.79128365
37BCL6_27268052_Chip-Seq_Bcells_Human1.77686718
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77330740
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76547601
40MYB_26560356_Chip-Seq_TH1_Human1.68458861
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67698289
42RUNX_20019798_ChIP-Seq_JUKART_Human1.67649503
43SPI1_23547873_ChIP-Seq_NB4_Human1.58119167
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.49168201
45BCOR_27268052_Chip-Seq_Bcells_Human1.46662921
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42172024
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41979985
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41935710
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.41893039
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.41715894
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.40872212
52CTCF_26484167_Chip-Seq_Bcells_Mouse1.39686994
53LXR_22292898_ChIP-Seq_THP-1_Human1.38250010
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37543462
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.37085636
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37046894
57XRN2_22483619_ChIP-Seq_HELA_Human1.36658547
58P68_20966046_ChIP-Seq_HELA_Human1.35208837
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33376582
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31994668
61VDR_24763502_ChIP-Seq_THP-1_Human1.31854613
62E2F1_20622854_ChIP-Seq_HELA_Human1.30491206
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.27551982
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27404900
65P300_27268052_Chip-Seq_Bcells_Human1.26531660
66GATA3_27048872_Chip-Seq_THYMUS_Human1.24947155
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23053357
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21784135
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19465930
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.16753673
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16490544
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15287513
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14828449
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14797566
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14184452
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13693007
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13690102
78GABP_19822575_ChIP-Seq_HepG2_Human1.12895868
79GATA3_26560356_Chip-Seq_TH2_Human1.12755534
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12272621
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12140338
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11507489
83CTCF_20526341_ChIP-Seq_ESCs_Human1.10636309
84TTF2_22483619_ChIP-Seq_HELA_Human1.09274038
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09088205
86SA1_27219007_Chip-Seq_Bcells_Human1.08717711
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.08188666
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07971629
89PHF8_20622854_ChIP-Seq_HELA_Human1.07235633
90STAT1_20625510_ChIP-Seq_HELA_Human1.06933595
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05053631
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02762280
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02716029
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01384768
95SPI1_20517297_ChIP-Seq_HL60_Human1.01060233
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00348210
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00335137
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00098949
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99915358
100CTCF_21964334_Chip-Seq_Bcells_Human0.98249618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.96383451
2MP0001835_abnormal_antigen_presentation3.79717402
3MP0003763_abnormal_thymus_physiology3.70994840
4MP0009379_abnormal_foot_pigmentation3.14589542
5MP0001800_abnormal_humoral_immune3.12226025
6MP0005000_abnormal_immune_tolerance3.03536158
7MP0009333_abnormal_splenocyte_physiolog2.95990616
8MP0001873_stomach_inflammation2.95731109
9MP0000685_abnormal_immune_system2.87795273
10MP0001790_abnormal_immune_system2.80284825
11MP0005387_immune_system_phenotype2.80284825
12MP0002723_abnormal_immune_serum2.66213509
13MP0003436_decreased_susceptibility_to2.59727139
14MP0002420_abnormal_adaptive_immunity2.55582310
15MP0009785_altered_susceptibility_to2.54931366
16MP0001819_abnormal_immune_cell2.53659263
17MP0002148_abnormal_hypersensitivity_rea2.50454797
18MP0005075_abnormal_melanosome_morpholog2.49547578
19MP0005025_abnormal_response_to2.48599580
20MP0002452_abnormal_antigen_presenting2.42041150
21MP0010155_abnormal_intestine_physiology2.24564702
22MP0003866_abnormal_defecation2.20364016
23MP0002138_abnormal_hepatobiliary_system2.16562655
24MP0003724_increased_susceptibility_to2.12627430
25MP0002398_abnormal_bone_marrow2.08008503
26MP0002166_altered_tumor_susceptibility2.06562304
27MP0000716_abnormal_immune_system2.02515193
28MP0002933_joint_inflammation1.90225535
29MP0002419_abnormal_innate_immunity1.77951240
30MP0003806_abnormal_nucleotide_metabolis1.77190249
31MP0000703_abnormal_thymus_morphology1.75612087
32MP0000689_abnormal_spleen_morphology1.74292394
33MP0001845_abnormal_inflammatory_respons1.73958777
34MP0004381_abnormal_hair_follicle1.70614538
35MP0002722_abnormal_immune_system1.69535515
36MP0002429_abnormal_blood_cell1.67958743
37MP0006082_CNS_inflammation1.66033994
38MP0004947_skin_inflammation1.56143214
39MP0002006_tumorigenesis1.45429191
40MP0008995_early_reproductive_senescence1.45100764
41MP0002405_respiratory_system_inflammati1.44999180
42MP0008469_abnormal_protein_level1.36579604
43MP0005645_abnormal_hypothalamus_physiol1.28711089
44MP0003786_premature_aging1.26662027
45MP0000372_irregular_coat_pigmentation1.24045075
46MP0005670_abnormal_white_adipose1.22540716
47MP0002277_abnormal_respiratory_mucosa1.22392395
48MP0001853_heart_inflammation1.22222796
49MP0008872_abnormal_physiological_respon1.21280386
50MP0000465_gastrointestinal_hemorrhage1.17733715
51MP0009764_decreased_sensitivity_to1.15018677
52MP0001533_abnormal_skeleton_physiology1.14984047
53MP0000490_abnormal_crypts_of1.13597772
54MP0005464_abnormal_platelet_physiology1.07583926
55MP0002163_abnormal_gland_morphology1.06404512
56MP0002019_abnormal_tumor_incidence1.01018978
57MP0001663_abnormal_digestive_system1.00725093
58MP0005646_abnormal_pituitary_gland0.96631733
59MP0005360_urolithiasis0.89541439
60MP0005377_hearing/vestibular/ear_phenot0.83822879
61MP0003878_abnormal_ear_physiology0.83822879
62MP0009643_abnormal_urine_homeostasis0.82888550
63MP0006292_abnormal_olfactory_placode0.82420408
64MP0005310_abnormal_salivary_gland0.82293521
65MP0002396_abnormal_hematopoietic_system0.76808281
66MP0005381_digestive/alimentary_phenotyp0.75810793
67MP0000858_altered_metastatic_potential0.74803184
68MP0004147_increased_porphyrin_level0.74624362
69MP0001919_abnormal_reproductive_system0.74493672
70MP0006036_abnormal_mitochondrial_physio0.73327221
71MP0003186_abnormal_redox_activity0.72185702
72MP0009763_increased_sensitivity_to0.72055167
73MP0001764_abnormal_homeostasis0.70953397
74MP0009765_abnormal_xenobiotic_induced0.70909708
75MP0009278_abnormal_bone_marrow0.69991907
76MP0003303_peritoneal_inflammation0.68979562
77MP0002693_abnormal_pancreas_physiology0.68690508
78MP0003646_muscle_fatigue0.67840311
79MP0001542_abnormal_bone_strength0.66387113
80MP0002136_abnormal_kidney_physiology0.65835881
81MP0001986_abnormal_taste_sensitivity0.65753873
82MP0002132_abnormal_respiratory_system0.65576248
83MP0002095_abnormal_skin_pigmentation0.64936486
84MP0000538_abnormal_urinary_bladder0.64758167
85MP0005390_skeleton_phenotype0.64259426
86MP0000015_abnormal_ear_pigmentation0.63955503
87MP0005058_abnormal_lysosome_morphology0.63857264
88MP0005166_decreased_susceptibility_to0.63181401
89MP0001905_abnormal_dopamine_level0.62273945
90MP0005174_abnormal_tail_pigmentation0.60696409
91MP0005389_reproductive_system_phenotype0.58647582
92MP0002822_catalepsy0.53752081
93MP0001348_abnormal_lacrimal_gland0.53122941
94MP0000343_altered_response_to0.52633451
95MP0000477_abnormal_intestine_morphology0.52248701
96MP0005319_abnormal_enzyme/_coenzyme0.52238394
97MP0008873_increased_physiological_sensi0.51918888
98MP0002102_abnormal_ear_morphology0.51769231
99MP0006035_abnormal_mitochondrial_morpho0.51587610
100MP0008058_abnormal_DNA_repair0.49864299

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.74822363
2Reticulocytopenia (HP:0001896)4.40651421
3IgG deficiency (HP:0004315)4.09947129
4Increased IgM level (HP:0003496)4.02883916
5Aplastic anemia (HP:0001915)3.66531238
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.61904068
7Abnormality of T cell number (HP:0011839)3.41333185
8Abnormality of T cells (HP:0002843)3.41119618
9Panhypogammaglobulinemia (HP:0003139)3.37203639
10Mitochondrial inheritance (HP:0001427)3.31091185
11Abnormality of cells of the erythroid lineage (HP:0012130)3.29881114
12Autoimmune hemolytic anemia (HP:0001890)3.25427015
13Acute necrotizing encephalopathy (HP:0006965)3.18401905
14Meningitis (HP:0001287)3.16526897
15T lymphocytopenia (HP:0005403)3.16513333
16Vasculitis (HP:0002633)3.14360564
17Abnormal number of erythroid precursors (HP:0012131)3.13194517
18IgM deficiency (HP:0002850)3.12466155
19Severe combined immunodeficiency (HP:0004430)3.12121394
20Abnormal mitochondria in muscle tissue (HP:0008316)3.05366647
21Agammaglobulinemia (HP:0004432)3.05135606
22Abnormality of T cell physiology (HP:0011840)3.03503436
23Hepatocellular necrosis (HP:0001404)3.01554192
24Lymphopenia (HP:0001888)2.96912370
25Abnormality of the prostate (HP:0008775)2.89811580
26Abnormality of cells of the lymphoid lineage (HP:0012140)2.89756746
27Eosinophilia (HP:0001880)2.83705925
28Granulocytopenia (HP:0001913)2.82598217
29Abnormality of eosinophils (HP:0001879)2.81531733
30Abnormality of B cell number (HP:0010975)2.81444375
31Gastrointestinal stroma tumor (HP:0100723)2.79857179
32Increased CSF lactate (HP:0002490)2.77904240
33Chronic obstructive pulmonary disease (HP:0006510)2.75835359
34Obstructive lung disease (HP:0006536)2.75835359
35Chronic diarrhea (HP:0002028)2.71223098
36Pancytopenia (HP:0001876)2.70278072
37Myositis (HP:0100614)2.70158493
38Acute encephalopathy (HP:0006846)2.69802364
39Leukocytosis (HP:0001974)2.68709138
40Stomatitis (HP:0010280)2.68218267
41Increased intramyocellular lipid droplets (HP:0012240)2.67989424
42Pustule (HP:0200039)2.65158923
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64414892
44Encephalitis (HP:0002383)2.63143753
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62506759
46Mediastinal lymphadenopathy (HP:0100721)2.60560179
47Macrocytic anemia (HP:0001972)2.60320069
48Autoimmune thrombocytopenia (HP:0001973)2.59725880
49Increased muscle lipid content (HP:0009058)2.58550204
50Hepatic necrosis (HP:0002605)2.51697180
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50622711
52Pallor (HP:0000980)2.50217748
53Recurrent bronchitis (HP:0002837)2.49369509
54Recurrent fungal infections (HP:0002841)2.49288056
55Combined immunodeficiency (HP:0005387)2.46442371
56Progressive macrocephaly (HP:0004481)2.44780389
57Increased hepatocellular lipid droplets (HP:0006565)2.44017473
58Hypergammaglobulinemia (HP:0010702)2.38213201
593-Methylglutaconic aciduria (HP:0003535)2.36453438
60Recurrent abscess formation (HP:0002722)2.36228187
61Chronic mucocutaneous candidiasis (HP:0002728)2.35025577
62Recurrent cutaneous fungal infections (HP:0011370)2.35025577
63Lipid accumulation in hepatocytes (HP:0006561)2.34279689
64Thrombocytosis (HP:0001894)2.33684024
65B lymphocytopenia (HP:0010976)2.31825481
66Recurrent viral infections (HP:0004429)2.29807900
67Pulmonary infiltrates (HP:0002113)2.27229081
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25601155
69Cerebral edema (HP:0002181)2.22624202
70Oral leukoplakia (HP:0002745)2.21478296
71Hypoproteinemia (HP:0003075)2.19863325
72Eczematoid dermatitis (HP:0000976)2.18710236
73Recurrent sinusitis (HP:0011108)2.18552273
74Gastrointestinal infarctions (HP:0005244)2.15580275
75Restrictive lung disease (HP:0002091)2.15397329
76IgA deficiency (HP:0002720)2.12731198
77Increased serum lactate (HP:0002151)2.12060335
78Neutropenia (HP:0001875)2.09310108
79Renal Fanconi syndrome (HP:0001994)2.07492405
80Lymphoma (HP:0002665)2.06691947
81Lactic acidosis (HP:0003128)2.06191592
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05626121
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05626121
84Abnormality of DNA repair (HP:0003254)2.04260729
85Abnormal rod and cone electroretinograms (HP:0008323)2.03109804
86Hemoptysis (HP:0002105)2.02546084
87Absent thumb (HP:0009777)2.00686804
88Cerebral palsy (HP:0100021)1.98028248
89Pulmonary fibrosis (HP:0002206)1.97681614
90Skin rash (HP:0000988)1.95920933
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93977534
92Dicarboxylic aciduria (HP:0003215)1.93977534
93Optic neuritis (HP:0100653)1.93977142
94Retrobulbar optic neuritis (HP:0100654)1.93977142
95Orchitis (HP:0100796)1.93284574
96Constricted visual fields (HP:0001133)1.88868899
97Urticaria (HP:0001025)1.88500507
98Abnormality of the pleura (HP:0002103)1.86638460
99Gastrointestinal inflammation (HP:0004386)1.86011745
100Optic disc pallor (HP:0000543)1.85364566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.27856404
2TXK4.57036507
3VRK23.23957206
4KDR3.09089257
5TESK22.70293316
6TAOK32.66047801
7TLK12.62310483
8CDK192.43178185
9BCKDK2.36462664
10NME22.26478511
11PASK2.07420887
12GRK61.99997870
13TBK11.99499532
14IKBKB1.92555966
15IKBKE1.83807070
16FES1.81109288
17ZAK1.77856197
18ITK1.72701037
19KIT1.70951945
20BTK1.60872370
21VRK11.57924676
22SYK1.53898688
23MAP3K111.42615878
24MAP2K21.30584963
25JAK31.30274075
26MUSK1.28625371
27TNK21.26351937
28MAP4K21.25253485
29CSF1R1.20702134
30LCK1.20371881
31RPS6KB21.20168370
32IRAK41.18972310
33TEC1.13911080
34MARK31.13324734
35TESK11.11006240
36PRKCQ1.09618688
37LYN1.07012822
38ZAP701.06667894
39TRIB31.06060468
40ADRBK21.04168007
41RIPK41.01397981
42CSK1.00909025
43SMG10.98953241
44GRK10.96126921
45RPS6KA50.95641334
46NUAK10.94924475
47MAPKAPK30.94026242
48MAP3K140.89743648
49DAPK30.87627627
50PINK10.86599961
51LRRK20.85533006
52TYK20.85123230
53DAPK10.81928684
54CAMKK10.76501831
55PIM20.75414593
56ERN10.69256366
57MAP3K100.66989421
58HCK0.64391535
59LIMK10.64119377
60ARAF0.61480182
61TAOK20.61279565
62PIM10.59251773
63STK160.59019723
64ILK0.56761320
65CHUK0.56367771
66SCYL20.54047274
67TIE10.53320747
68PRKCH0.53062835
69CDK40.52079147
70MATK0.51501798
71MYLK0.48879057
72AURKA0.48133537
73PRKCD0.47386309
74PDK10.47106716
75RPS6KA60.45236740
76PRPF4B0.44252039
77RPS6KL10.44037202
78RPS6KC10.44037202
79MAPKAPK20.43645514
80BLK0.42821998
81SIK10.41777409
82MAPK110.41532644
83NME10.40666018
84CAMKK20.40037582
85PKN20.39029261
86MAPK70.38388591
87GRK50.38290311
88BUB10.35675158
89CDK80.34786054
90ADRBK10.34395715
91MAP3K130.34258243
92PTK60.34218109
93PIK3CA0.34058298
94MAP2K30.32682139
95MAP2K70.32444407
96GRK70.32394718
97MAPK40.32283855
98TAF10.32098401
99HIPK20.32090278
100PAK10.31429461

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.52268251
2Allograft rejection_Homo sapiens_hsa053304.31684010
3Primary immunodeficiency_Homo sapiens_hsa053404.28882578
4Autoimmune thyroid disease_Homo sapiens_hsa053204.09596933
5Graft-versus-host disease_Homo sapiens_hsa053324.02078759
6Asthma_Homo sapiens_hsa053103.78120803
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.51736988
8Type I diabetes mellitus_Homo sapiens_hsa049403.21367898
9Antigen processing and presentation_Homo sapiens_hsa046122.76620709
10Proteasome_Homo sapiens_hsa030502.39501411
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31398046
12Viral myocarditis_Homo sapiens_hsa054162.27385304
13Oxidative phosphorylation_Homo sapiens_hsa001902.13498638
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93262895
15Hematopoietic cell lineage_Homo sapiens_hsa046401.83005967
16Parkinsons disease_Homo sapiens_hsa050121.82341310
17Systemic lupus erythematosus_Homo sapiens_hsa053221.77418417
18RNA polymerase_Homo sapiens_hsa030201.72829614
19Rheumatoid arthritis_Homo sapiens_hsa053231.71554442
20Leishmaniasis_Homo sapiens_hsa051401.68623230
21Staphylococcus aureus infection_Homo sapiens_hsa051501.67279454
22T cell receptor signaling pathway_Homo sapiens_hsa046601.60395661
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50497905
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.36113131
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34183218
26Herpes simplex infection_Homo sapiens_hsa051681.23998423
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09795302
28Pyrimidine metabolism_Homo sapiens_hsa002401.07284230
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02503302
30Sulfur relay system_Homo sapiens_hsa041221.01156952
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99832407
32Huntingtons disease_Homo sapiens_hsa050160.98124065
33Alzheimers disease_Homo sapiens_hsa050100.98115766
34Measles_Homo sapiens_hsa051620.98095942
35B cell receptor signaling pathway_Homo sapiens_hsa046620.94925252
36Base excision repair_Homo sapiens_hsa034100.91554985
37Epstein-Barr virus infection_Homo sapiens_hsa051690.90462666
38Spliceosome_Homo sapiens_hsa030400.87701588
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81943219
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.81115023
41Malaria_Homo sapiens_hsa051440.75241347
42RNA degradation_Homo sapiens_hsa030180.74741612
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72205976
44HTLV-I infection_Homo sapiens_hsa051660.72196253
45DNA replication_Homo sapiens_hsa030300.69861558
46Influenza A_Homo sapiens_hsa051640.69353048
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68758980
48Toxoplasmosis_Homo sapiens_hsa051450.66614157
49Purine metabolism_Homo sapiens_hsa002300.66394510
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64600006
51Linoleic acid metabolism_Homo sapiens_hsa005910.64170300
52Osteoclast differentiation_Homo sapiens_hsa043800.61398463
53Tuberculosis_Homo sapiens_hsa051520.60015371
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53328697
55Arachidonic acid metabolism_Homo sapiens_hsa005900.50900073
56Legionellosis_Homo sapiens_hsa051340.49732309
57Homologous recombination_Homo sapiens_hsa034400.47942752
58Cardiac muscle contraction_Homo sapiens_hsa042600.45812099
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45071240
60Fat digestion and absorption_Homo sapiens_hsa049750.44545575
61Apoptosis_Homo sapiens_hsa042100.43615899
62Shigellosis_Homo sapiens_hsa051310.40261199
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38953682
64Alcoholism_Homo sapiens_hsa050340.36668194
65Glutathione metabolism_Homo sapiens_hsa004800.36448349
66Fanconi anemia pathway_Homo sapiens_hsa034600.33402433
67TNF signaling pathway_Homo sapiens_hsa046680.33397086
68Phagosome_Homo sapiens_hsa041450.32985227
69Viral carcinogenesis_Homo sapiens_hsa052030.32064837
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.31384313
71Chemical carcinogenesis_Homo sapiens_hsa052040.30869712
72Chemokine signaling pathway_Homo sapiens_hsa040620.30804581
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30632283
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30000625
75Peroxisome_Homo sapiens_hsa041460.29822752
76Pertussis_Homo sapiens_hsa051330.29677616
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.29610189
78Nucleotide excision repair_Homo sapiens_hsa034200.24856957
79RNA transport_Homo sapiens_hsa030130.24856085
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23666941
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22315870
82One carbon pool by folate_Homo sapiens_hsa006700.22211072
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22027166
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21770268
85Protein export_Homo sapiens_hsa030600.21284795
86Basal transcription factors_Homo sapiens_hsa030220.21228353
87Metabolic pathways_Homo sapiens_hsa011000.21221010
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20534478
89Phototransduction_Homo sapiens_hsa047440.20393117
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19934271
91Mismatch repair_Homo sapiens_hsa034300.19239625
92Acute myeloid leukemia_Homo sapiens_hsa052210.18892731
93Other glycan degradation_Homo sapiens_hsa005110.16293396
94Pentose phosphate pathway_Homo sapiens_hsa000300.15676971
95Nitrogen metabolism_Homo sapiens_hsa009100.15673633
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15469231
97N-Glycan biosynthesis_Homo sapiens_hsa005100.13221107
98Vitamin digestion and absorption_Homo sapiens_hsa049770.13076685
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12496681
100Sulfur metabolism_Homo sapiens_hsa009200.11950410

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