RPL13P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.02902362
2viral transcription (GO:0019083)7.40599248
3translational termination (GO:0006415)7.07098576
4ribosomal small subunit biogenesis (GO:0042274)6.80337554
5maturation of SSU-rRNA (GO:0030490)6.25765420
6translational elongation (GO:0006414)6.14335382
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.90656769
8protein targeting to ER (GO:0045047)5.82019880
9cotranslational protein targeting to membrane (GO:0006613)5.80739110
10DNA deamination (GO:0045006)5.62181405
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.61190973
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.59488719
13protein localization to endoplasmic reticulum (GO:0070972)5.49278106
14cellular protein complex disassembly (GO:0043624)5.34469166
15viral life cycle (GO:0019058)5.30866487
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.98926881
17ATP synthesis coupled proton transport (GO:0015986)4.66846800
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66846800
19protein complex disassembly (GO:0043241)4.45484829
20translational initiation (GO:0006413)4.36178969
21behavioral response to nicotine (GO:0035095)4.34443825
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33295357
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27128201
24macromolecular complex disassembly (GO:0032984)4.24082825
25cytidine deamination (GO:0009972)4.04614700
26cytidine metabolic process (GO:0046087)4.04614700
27cytidine catabolic process (GO:0006216)4.04614700
28protein neddylation (GO:0045116)4.04566752
29protein targeting to membrane (GO:0006612)3.90111107
30chaperone-mediated protein transport (GO:0072321)3.76935502
31respiratory electron transport chain (GO:0022904)3.65319144
32ncRNA 3-end processing (GO:0043628)3.64365545
33electron transport chain (GO:0022900)3.63614457
34translation (GO:0006412)3.54892407
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.52299842
36ribosomal large subunit biogenesis (GO:0042273)3.48828657
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.47789861
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44937510
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.44937510
40NADH dehydrogenase complex assembly (GO:0010257)3.44937510
41protein complex biogenesis (GO:0070271)3.44079225
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.41954471
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38552359
44mRNA catabolic process (GO:0006402)3.35847581
45positive regulation of T cell apoptotic process (GO:0070234)3.19399212
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17845652
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17845652
48negative regulation of telomere maintenance (GO:0032205)3.08865022
49water-soluble vitamin biosynthetic process (GO:0042364)3.01856628
50RNA catabolic process (GO:0006401)2.99767462
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98952282
52cellular component biogenesis (GO:0044085)2.98784260
53ribonucleoprotein complex biogenesis (GO:0022613)2.98099177
54GTP biosynthetic process (GO:0006183)2.96289403
55mitochondrial respiratory chain complex assembly (GO:0033108)2.92625525
56cell proliferation in forebrain (GO:0021846)2.90941908
57negative regulation by host of viral transcription (GO:0043922)2.86453324
58negative regulation of appetite (GO:0032099)2.86253647
59negative regulation of response to food (GO:0032096)2.86253647
60pyrimidine nucleotide catabolic process (GO:0006244)2.82753910
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78131023
62base-excision repair, AP site formation (GO:0006285)2.76176154
63purine nucleoside triphosphate biosynthetic process (GO:0009145)2.76110638
64regulation of regulatory T cell differentiation (GO:0045589)2.73802957
65ATP biosynthetic process (GO:0006754)2.72396798
66transmission of nerve impulse (GO:0019226)2.69711364
67somite development (GO:0061053)2.67095216
68negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62948329
69establishment of protein localization to membrane (GO:0090150)2.61964919
70cellular response to interleukin-15 (GO:0071350)2.60774624
71mannosylation (GO:0097502)2.60234077
72hydrogen ion transmembrane transport (GO:1902600)2.58789318
73sequestering of actin monomers (GO:0042989)2.57204670
74regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56624248
75positive regulation of defense response to virus by host (GO:0002230)2.56529660
76regulation of leukocyte mediated cytotoxicity (GO:0001910)2.53711656
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52368068
78kynurenine metabolic process (GO:0070189)2.51827652
79positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.50762154
80positive regulation of prostaglandin secretion (GO:0032308)2.50264118
81negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.48712500
82negative T cell selection (GO:0043383)2.47680472
83tongue development (GO:0043586)2.47156655
84proton transport (GO:0015992)2.43930526
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.42285228
86UTP biosynthetic process (GO:0006228)2.42220041
87neuron fate determination (GO:0048664)2.42180163
88protein targeting (GO:0006605)2.41927665
89positive regulation of lymphocyte apoptotic process (GO:0070230)2.41827356
90rhodopsin mediated signaling pathway (GO:0016056)2.41538555
91substrate-independent telencephalic tangential migration (GO:0021826)2.41165959
92substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41165959
93positive regulation of calcium-mediated signaling (GO:0050850)2.40044901
94hydrogen transport (GO:0006818)2.40011867
95tryptophan catabolic process (GO:0006569)2.39686008
96indole-containing compound catabolic process (GO:0042436)2.39686008
97indolalkylamine catabolic process (GO:0046218)2.39686008
98positive T cell selection (GO:0043368)2.39453152
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39028835
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38542162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.09732785
2EZH2_22144423_ChIP-Seq_EOC_Human4.74529943
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.28401494
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.05357483
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.00643867
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43722731
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34779545
8VDR_22108803_ChIP-Seq_LS180_Human2.25254107
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.17064209
10ZNF274_21170338_ChIP-Seq_K562_Hela2.13681733
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11593873
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.09882938
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07924837
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89573036
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87969399
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.81480937
17VDR_23849224_ChIP-Seq_CD4+_Human1.78100215
18IRF1_19129219_ChIP-ChIP_H3396_Human1.78085571
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76194582
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69972135
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.66486424
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61967531
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61849767
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57645977
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.57405588
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57332401
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53242551
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.52116497
29MYC_18940864_ChIP-ChIP_HL60_Human1.47927758
30BCL6_27268052_Chip-Seq_Bcells_Human1.46584842
31TP53_22573176_ChIP-Seq_HFKS_Human1.45398767
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44717298
33TAF2_19829295_ChIP-Seq_ESCs_Human1.44299423
34NANOG_20526341_ChIP-Seq_ESCs_Human1.43211130
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42669150
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42182976
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38370681
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37514636
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.36884395
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.34845592
41ERA_21632823_ChIP-Seq_H3396_Human1.34627744
42CTCF_20526341_ChIP-Seq_ESCs_Human1.32797220
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.30606086
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30300035
45NCOR_22424771_ChIP-Seq_293T_Human1.30027780
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28248672
47FOXP3_21729870_ChIP-Seq_TREG_Human1.24543964
48AR_20517297_ChIP-Seq_VCAP_Human1.18366535
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.16510634
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.16269839
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15393905
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14064793
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13977600
54IGF1R_20145208_ChIP-Seq_DFB_Human1.13147783
55SA1_27219007_Chip-Seq_Bcells_Human1.12636594
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12104036
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11656713
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11623650
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.11500362
60CTCF_27219007_Chip-Seq_Bcells_Human1.10445019
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09913923
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08524541
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08148046
64P300_27268052_Chip-Seq_Bcells_Human1.07764401
65RUNX_20019798_ChIP-Seq_JUKART_Human1.07624570
66E2F1_20622854_ChIP-Seq_HELA_Human1.07407149
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07403543
68RNF2_27304074_Chip-Seq_NSC_Mouse1.05995218
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04390505
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04327517
71MYC_19829295_ChIP-Seq_ESCs_Human1.04209503
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03904531
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02450795
74P53_21459846_ChIP-Seq_SAOS-2_Human1.02314887
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02035520
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01784259
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00827068
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00537010
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.00537010
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99528356
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98901543
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98755342
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95996337
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.95537186
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95012777
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94985553
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94467374
88GATA3_26560356_Chip-Seq_TH2_Human0.94447985
89TTF2_22483619_ChIP-Seq_HELA_Human0.94146781
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93508108
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.93357727
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92575609
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91315301
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.91245575
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.90868989
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90853010
97REST_21632747_ChIP-Seq_MESCs_Mouse0.90504547
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90449401
99EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90449401
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.89722314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.00625138
2MP0006292_abnormal_olfactory_placode4.23797586
3MP0005671_abnormal_response_to3.40027792
4MP0002163_abnormal_gland_morphology2.41486990
5MP0002102_abnormal_ear_morphology2.34817568
6MP0005646_abnormal_pituitary_gland2.24497927
7MP0002653_abnormal_ependyma_morphology2.18761274
8MP0003787_abnormal_imprinting2.13883184
9MP0003878_abnormal_ear_physiology2.11591082
10MP0005377_hearing/vestibular/ear_phenot2.11591082
11MP0004147_increased_porphyrin_level1.92413292
12MP0003646_muscle_fatigue1.88914891
13MP0004885_abnormal_endolymph1.88340962
14MP0008877_abnormal_DNA_methylation1.87838400
15MP0004142_abnormal_muscle_tone1.84534342
16MP0005551_abnormal_eye_electrophysiolog1.81008730
17MP0001873_stomach_inflammation1.79731356
18MP0006072_abnormal_retinal_apoptosis1.77579244
19MP0008789_abnormal_olfactory_epithelium1.66910879
20MP0001968_abnormal_touch/_nociception1.63881166
21MP0003011_delayed_dark_adaptation1.63480501
22MP0005645_abnormal_hypothalamus_physiol1.61609078
23MP0002837_dystrophic_cardiac_calcinosis1.57665732
24MP0005379_endocrine/exocrine_gland_phen1.55086712
25MP0001905_abnormal_dopamine_level1.54308687
26MP0006276_abnormal_autonomic_nervous1.49631021
27MP0009785_altered_susceptibility_to1.46918212
28MP0002638_abnormal_pupillary_reflex1.40326347
29MP0003136_yellow_coat_color1.38057084
30MP0009333_abnormal_splenocyte_physiolog1.34857270
31MP0001800_abnormal_humoral_immune1.34449359
32MP0001835_abnormal_antigen_presentation1.33430859
33MP0008875_abnormal_xenobiotic_pharmacok1.33330966
34MP0000049_abnormal_middle_ear1.32118914
35MP0008872_abnormal_physiological_respon1.31936458
36MP0001485_abnormal_pinna_reflex1.31205454
37MP0002138_abnormal_hepatobiliary_system1.31023345
38MP0000372_irregular_coat_pigmentation1.27865216
39MP0003879_abnormal_hair_cell1.27508815
40MP0001293_anophthalmia1.26052608
41MP0005075_abnormal_melanosome_morpholog1.24825857
42MP0002736_abnormal_nociception_after1.23420517
43MP0002277_abnormal_respiratory_mucosa1.22112827
44MP0002234_abnormal_pharynx_morphology1.20157194
45MP0001919_abnormal_reproductive_system1.20067819
46MP0005394_taste/olfaction_phenotype1.19519282
47MP0005499_abnormal_olfactory_system1.19519282
48MP0002095_abnormal_skin_pigmentation1.19444424
49MP0000026_abnormal_inner_ear1.19411997
50MP0003880_abnormal_central_pattern1.18433930
51MP0001984_abnormal_olfaction1.17566269
52MP0000685_abnormal_immune_system1.16226012
53MP0000631_abnormal_neuroendocrine_gland1.16062664
54MP0004145_abnormal_muscle_electrophysio1.14493532
55MP0005389_reproductive_system_phenotype1.14435657
56MP0002876_abnormal_thyroid_physiology1.14108583
57MP0002723_abnormal_immune_serum1.12412703
58MP0002272_abnormal_nervous_system1.11297643
59MP0002148_abnormal_hypersensitivity_rea1.09993445
60MP0003866_abnormal_defecation1.09589673
61MP0003763_abnormal_thymus_physiology1.07330077
62MP0003121_genomic_imprinting1.07064506
63MP0009745_abnormal_behavioral_response1.06933339
64MP0002933_joint_inflammation1.03685479
65MP0005084_abnormal_gallbladder_morpholo1.03660056
66MP0001529_abnormal_vocalization1.03535126
67MP0003938_abnormal_ear_development1.03159157
68MP0001963_abnormal_hearing_physiology1.01969639
69MP0005253_abnormal_eye_physiology1.01673888
70MP0002420_abnormal_adaptive_immunity1.01666474
71MP0001819_abnormal_immune_cell0.99700225
72MP0005195_abnormal_posterior_eye0.99510386
73MP0005387_immune_system_phenotype0.97687104
74MP0001790_abnormal_immune_system0.97687104
75MP0005000_abnormal_immune_tolerance0.95657230
76MP0005174_abnormal_tail_pigmentation0.92413501
77MP0002160_abnormal_reproductive_system0.91400727
78MP0001970_abnormal_pain_threshold0.91255791
79MP0002733_abnormal_thermal_nociception0.90518796
80MP0003122_maternal_imprinting0.90307758
81MP0004043_abnormal_pH_regulation0.90109160
82MP0001663_abnormal_digestive_system0.89725692
83MP0002557_abnormal_social/conspecific_i0.89303585
84MP0004742_abnormal_vestibular_system0.88060608
85MP0002405_respiratory_system_inflammati0.87706852
86MP0005025_abnormal_response_to0.87548329
87MP0001348_abnormal_lacrimal_gland0.84744965
88MP0009764_decreased_sensitivity_to0.83098314
89MP0002752_abnormal_somatic_nervous0.82892829
90MP0000678_abnormal_parathyroid_gland0.81789788
91MP0001501_abnormal_sleep_pattern0.81217713
92MP0001440_abnormal_grooming_behavior0.80318411
93MP0002452_abnormal_antigen_presenting0.79841251
94MP0008995_early_reproductive_senescence0.79344198
95MP0001986_abnormal_taste_sensitivity0.78081943
96MP0002938_white_spotting0.77977014
97MP0006082_CNS_inflammation0.77712369
98MP0000716_abnormal_immune_system0.76794119
99MP0003638_abnormal_response/metabolism_0.76127753
100MP0002822_catalepsy0.75695776

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.41740169
2Acute necrotizing encephalopathy (HP:0006965)4.19314352
3Abnormality of cells of the erythroid lineage (HP:0012130)4.10670211
4Abnormal mitochondria in muscle tissue (HP:0008316)3.81903774
5Mitochondrial inheritance (HP:0001427)3.81167726
6Abnormal number of erythroid precursors (HP:0012131)3.61106762
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.57289656
8Acute encephalopathy (HP:0006846)3.56109364
9Pancreatic cysts (HP:0001737)3.43684751
10Progressive macrocephaly (HP:0004481)3.29967360
11Pancreatic fibrosis (HP:0100732)3.25767776
12Macrocytic anemia (HP:0001972)3.25291438
13Congenital stationary night blindness (HP:0007642)3.22090662
14Increased CSF lactate (HP:0002490)3.17298877
15Molar tooth sign on MRI (HP:0002419)3.15312208
16Abnormality of midbrain morphology (HP:0002418)3.15312208
17Type II lissencephaly (HP:0007260)3.13281178
18Abnormal rod and cone electroretinograms (HP:0008323)3.11494332
19Optic disc pallor (HP:0000543)3.02087603
20Elevated erythrocyte sedimentation rate (HP:0003565)2.96155474
21Hepatocellular necrosis (HP:0001404)2.96107138
223-Methylglutaconic aciduria (HP:0003535)2.92414974
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.85603808
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.85569675
25IgG deficiency (HP:0004315)2.83839528
26Renal Fanconi syndrome (HP:0001994)2.81235013
27True hermaphroditism (HP:0010459)2.78920208
28Asplenia (HP:0001746)2.74585135
29Constricted visual fields (HP:0001133)2.73165866
30Polydipsia (HP:0001959)2.72347403
31Abnormal drinking behavior (HP:0030082)2.72347403
32Pallor (HP:0000980)2.69874921
33Increased hepatocellular lipid droplets (HP:0006565)2.69475578
34Attenuation of retinal blood vessels (HP:0007843)2.66831934
35Absent thumb (HP:0009777)2.65329861
36Cerebral edema (HP:0002181)2.60796145
37Lipid accumulation in hepatocytes (HP:0006561)2.60694920
38Aplastic anemia (HP:0001915)2.59546506
39Hepatic necrosis (HP:0002605)2.54026860
40Increased intramyocellular lipid droplets (HP:0012240)2.53307522
41Septo-optic dysplasia (HP:0100842)2.49224585
42Medial flaring of the eyebrow (HP:0010747)2.46866793
43Nephronophthisis (HP:0000090)2.45632677
44Congenital, generalized hypertrichosis (HP:0004540)2.39501211
45Abnormality of the renal cortex (HP:0011035)2.35886613
46Abolished electroretinogram (ERG) (HP:0000550)2.27371354
47Sclerocornea (HP:0000647)2.27044422
48Polyuria (HP:0000103)2.22222764
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21724741
50Pendular nystagmus (HP:0012043)2.19933906
51Increased muscle lipid content (HP:0009058)2.18128544
52Cystic liver disease (HP:0006706)2.15409583
53Absent/shortened dynein arms (HP:0200106)2.13348359
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.13348359
55Severe visual impairment (HP:0001141)2.13324268
56Abnormality of macular pigmentation (HP:0008002)2.12369921
57Failure to thrive in infancy (HP:0001531)2.10561259
58Hypoplasia of the radius (HP:0002984)2.09236037
59Severe combined immunodeficiency (HP:0004430)2.09190361
60Abnormal respiratory epithelium morphology (HP:0012253)2.07619265
61Abnormal respiratory motile cilium morphology (HP:0005938)2.07619265
62Decreased central vision (HP:0007663)2.07417867
63Abnormality of the renal medulla (HP:0100957)2.05890192
64Lactic acidosis (HP:0003128)2.05018521
65Rib fusion (HP:0000902)2.03138299
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00906979
67Abnormality of renal resorption (HP:0011038)1.99404993
68Forearm undergrowth (HP:0009821)1.95479420
69Increased serum lactate (HP:0002151)1.93638547
70T lymphocytopenia (HP:0005403)1.92499803
71Gait imbalance (HP:0002141)1.91846405
72Renal cortical cysts (HP:0000803)1.91838330
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90490461
74Postaxial foot polydactyly (HP:0001830)1.89500679
75Abnormal respiratory motile cilium physiology (HP:0012261)1.89419348
76Hyperglycinemia (HP:0002154)1.89238696
77Abnormality of T cell number (HP:0011839)1.88321773
78Hypoproteinemia (HP:0003075)1.88166784
79Anencephaly (HP:0002323)1.88136588
80Congenital primary aphakia (HP:0007707)1.87767014
81Symphalangism affecting the phalanges of the hand (HP:0009773)1.87529930
82Generalized aminoaciduria (HP:0002909)1.86612485
83Partial duplication of thumb phalanx (HP:0009944)1.86397175
84Increased IgM level (HP:0003496)1.85997394
85Keratoconus (HP:0000563)1.85249552
86Increased corneal curvature (HP:0100692)1.85249552
87Hypoplasia of the ulna (HP:0003022)1.85171395
88Exertional dyspnea (HP:0002875)1.81225571
89Concave nail (HP:0001598)1.80738548
90Abnormal urine output (HP:0012590)1.80190064
91Cerebellar dysplasia (HP:0007033)1.79426738
92Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78575427
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78575427
94Depressed nasal ridge (HP:0000457)1.77773644
95Glycosuria (HP:0003076)1.76660323
96Abnormality of urine glucose concentration (HP:0011016)1.76660323
97Leukodystrophy (HP:0002415)1.76604804
98Tubular atrophy (HP:0000092)1.75957825
99Stomatitis (HP:0010280)1.75862882
100Triphalangeal thumb (HP:0001199)1.75673424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.95765526
2BCKDK3.45015086
3TLK13.17867281
4KDR3.07745719
5MAP4K12.60655319
6TESK22.54380389
7TIE12.52894645
8WNK42.49538436
9CDK192.48003612
10TAOK32.47093184
11KIT2.43960848
12ZAK2.42038857
13ADRBK22.06844741
14MAP4K22.00852321
15VRK21.97729437
16GRK11.97441941
17FES1.86955653
18PINK11.74500704
19NUAK11.70705519
20MAP3K111.68218756
21TEC1.62507363
22LIMK11.61148016
23STK161.58241324
24MUSK1.51346964
25IKBKE1.37316590
26GRK61.36493984
27IKBKB1.29960516
28PRKCQ1.26961531
29VRK11.25822870
30DYRK21.21874039
31ITK1.20570677
32SYK1.18206769
33CAMKK21.17838795
34PASK1.16782481
35FRK1.07706148
36MAPK151.06072237
37TYRO31.05138725
38MAP2K71.04404227
39CAMKK11.02455921
40BTK1.01968789
41WNK30.94524813
42TNK20.86315222
43LRRK20.85507156
44ADRBK10.85239869
45BMPR1B0.84603102
46MAPKAPK30.83520040
47PIK3CA0.83369635
48LCK0.81005690
49CAMK10.80834379
50NTRK20.78687493
51INSRR0.78614872
52CSF1R0.78410455
53MAP3K120.77621335
54AURKA0.77565228
55STK390.76592731
56CSK0.72778891
57RPS6KA50.72768065
58DAPK30.72115452
59MAP2K20.71728736
60LYN0.71148826
61DAPK20.69645140
62RPS6KA60.64430329
63SIK20.61105282
64PRKCG0.60809458
65EPHA40.59437773
66GRK70.58284650
67PRKACA0.58037847
68PIM10.57049722
69OBSCN0.56007772
70MAP3K40.55935004
71EPHB20.55511898
72DAPK10.55288359
73MATK0.55082798
74MAPK130.54291062
75NME20.53708716
76PIM20.53296526
77NME10.53263393
78TBK10.50566112
79FLT30.50055049
80CDC70.49507272
81OXSR10.48988332
82MARK30.48534078
83PRKCH0.48405710
84PRKCA0.46992864
85CDK80.45575589
86RPS6KC10.43921960
87RPS6KL10.43921960
88CHEK20.43440355
89ZAP700.42644717
90SCYL20.42552176
91CSNK2A20.39954211
92MAPKAPK50.38044287
93RPS6KB20.37997115
94CSNK2A10.37744513
95CSNK1G30.37731688
96CSNK1A10.37179150
97TESK10.36738061
98CSNK1G20.35575922
99PRKCD0.34828912
100CAMK2A0.34669011

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.44868614
2Oxidative phosphorylation_Homo sapiens_hsa001904.25638918
3Parkinsons disease_Homo sapiens_hsa050123.44424593
4Primary immunodeficiency_Homo sapiens_hsa053402.98088323
5Phototransduction_Homo sapiens_hsa047442.41345997
6Alzheimers disease_Homo sapiens_hsa050102.39463515
7Cardiac muscle contraction_Homo sapiens_hsa042602.35313114
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31431338
9Proteasome_Homo sapiens_hsa030502.24198154
10Huntingtons disease_Homo sapiens_hsa050162.17726833
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88287366
12RNA polymerase_Homo sapiens_hsa030201.87919671
13Linoleic acid metabolism_Homo sapiens_hsa005911.87409356
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84300453
15Graft-versus-host disease_Homo sapiens_hsa053321.77076736
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71375493
17Autoimmune thyroid disease_Homo sapiens_hsa053201.66487262
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63774782
19Allograft rejection_Homo sapiens_hsa053301.57737962
20Asthma_Homo sapiens_hsa053101.51762400
21Nitrogen metabolism_Homo sapiens_hsa009101.44725502
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.43892943
23Hematopoietic cell lineage_Homo sapiens_hsa046401.38775694
24Antigen processing and presentation_Homo sapiens_hsa046121.34997007
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32805116
26Homologous recombination_Homo sapiens_hsa034401.32243971
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23353073
28RNA degradation_Homo sapiens_hsa030181.18043117
29Protein export_Homo sapiens_hsa030601.17105646
30Pyrimidine metabolism_Homo sapiens_hsa002401.15673527
31Type I diabetes mellitus_Homo sapiens_hsa049401.13071816
32Fanconi anemia pathway_Homo sapiens_hsa034601.11306333
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04052539
34Nicotine addiction_Homo sapiens_hsa050331.03139195
35Peroxisome_Homo sapiens_hsa041461.01521660
36Rheumatoid arthritis_Homo sapiens_hsa053230.97316546
37Arachidonic acid metabolism_Homo sapiens_hsa005900.96038098
38Sulfur relay system_Homo sapiens_hsa041220.95930466
39Tryptophan metabolism_Homo sapiens_hsa003800.94637723
40Basal transcription factors_Homo sapiens_hsa030220.92486927
41T cell receptor signaling pathway_Homo sapiens_hsa046600.91326439
42Olfactory transduction_Homo sapiens_hsa047400.90330387
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89793613
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89006916
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86581805
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.84653913
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84020309
48Nucleotide excision repair_Homo sapiens_hsa034200.82353364
49Retinol metabolism_Homo sapiens_hsa008300.81185016
50Purine metabolism_Homo sapiens_hsa002300.80688912
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79780826
52Fat digestion and absorption_Homo sapiens_hsa049750.79313609
53Caffeine metabolism_Homo sapiens_hsa002320.78824073
54Ether lipid metabolism_Homo sapiens_hsa005650.77383483
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76573527
56Chemical carcinogenesis_Homo sapiens_hsa052040.74509400
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74127823
58Morphine addiction_Homo sapiens_hsa050320.73623392
59One carbon pool by folate_Homo sapiens_hsa006700.71437710
60Mismatch repair_Homo sapiens_hsa034300.69873795
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65610677
62Base excision repair_Homo sapiens_hsa034100.64975210
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.62475626
64Metabolic pathways_Homo sapiens_hsa011000.61371512
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58442474
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57580401
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54778632
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54351654
69Malaria_Homo sapiens_hsa051440.54222134
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53933912
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53075720
72Basal cell carcinoma_Homo sapiens_hsa052170.48889194
73Ovarian steroidogenesis_Homo sapiens_hsa049130.47941813
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.47867839
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47618533
76Systemic lupus erythematosus_Homo sapiens_hsa053220.47472469
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47300335
78DNA replication_Homo sapiens_hsa030300.45240117
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44524552
80Collecting duct acid secretion_Homo sapiens_hsa049660.43879511
81Taste transduction_Homo sapiens_hsa047420.41757689
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41691751
83Butanoate metabolism_Homo sapiens_hsa006500.41215400
84Propanoate metabolism_Homo sapiens_hsa006400.38065689
85Glycerolipid metabolism_Homo sapiens_hsa005610.36426464
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.35520302
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35509236
88Spliceosome_Homo sapiens_hsa030400.34719497
89Hedgehog signaling pathway_Homo sapiens_hsa043400.34666626
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33734311
91Selenocompound metabolism_Homo sapiens_hsa004500.32975141
92Serotonergic synapse_Homo sapiens_hsa047260.32244583
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.29251377
94Measles_Homo sapiens_hsa051620.29061583
95Sulfur metabolism_Homo sapiens_hsa009200.28504711
96Circadian entrainment_Homo sapiens_hsa047130.26239334
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26206372
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.24725380
99Steroid biosynthesis_Homo sapiens_hsa001000.24688116
100Viral myocarditis_Homo sapiens_hsa054160.24364477

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