RPL13P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of nucleus localization (GO:0040023)9.63267684
2cerebral cortex radially oriented cell migration (GO:0021799)8.18536813
3regulation of heat generation (GO:0031650)8.09826389
4intracellular lipid transport (GO:0032365)7.52339956
5regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)7.48366630
6negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)7.36276148
7regulation of NFAT protein import into nucleus (GO:0051532)7.33643113
8peripheral nervous system axon ensheathment (GO:0032292)7.24997511
9myelination in peripheral nervous system (GO:0022011)7.24997511
10nucleoside diphosphate catabolic process (GO:0009134)6.82044554
11oxidative phosphorylation (GO:0006119)6.28013617
12regulation of actin nucleation (GO:0051125)5.90574085
13nucleus localization (GO:0051647)5.60887720
14Rac protein signal transduction (GO:0016601)5.52439355
15germ cell migration (GO:0008354)5.26904835
16substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.95429587
17substrate-independent telencephalic tangential migration (GO:0021826)4.95429587
18histone H3-K36 demethylation (GO:0070544)4.80310955
19positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.77212458
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.66990544
21cerebral cortex cell migration (GO:0021795)4.61061508
22microtubule depolymerization (GO:0007019)4.59281492
23positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.54911310
24regulation of transcription from RNA polymerase III promoter (GO:0006359)4.53792113
25negative regulation of protein tyrosine kinase activity (GO:0061099)4.48144783
26polyol transport (GO:0015791)4.34621621
27astrocyte development (GO:0014002)4.23973365
28negative regulation of multicellular organism growth (GO:0040015)4.23115055
29regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.19581711
30negative regulation of receptor activity (GO:2000272)4.19226561
31positive regulation of cardiac muscle cell differentiation (GO:2000727)4.14246048
32DNA-dependent DNA replication (GO:0006261)4.10145366
33regulation of ARF GTPase activity (GO:0032312)4.04245108
34limb bud formation (GO:0060174)4.03298672
35head development (GO:0060322)4.00828852
36positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.98657871
37osteoblast development (GO:0002076)3.97058346
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.89587803
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.86288633
40adaptation of signaling pathway (GO:0023058)3.83686040
41temperature homeostasis (GO:0001659)3.78119919
42sister chromatid cohesion (GO:0007062)3.76648105
43negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.75521319
44adrenergic receptor signaling pathway (GO:0071875)3.74700124
45positive regulation of cardiac muscle hypertrophy (GO:0010613)3.71344251
46positive regulation of muscle hypertrophy (GO:0014742)3.71344251
47negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.69887283
48negative regulation of nucleotide biosynthetic process (GO:0030809)3.69887283
49pharyngeal system development (GO:0060037)3.67549270
50negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.57451127
51atrial cardiac muscle cell action potential (GO:0086014)3.55126191
52lateral ventricle development (GO:0021670)3.44892148
53negative regulation of norepinephrine secretion (GO:0010700)3.43937145
54ether lipid metabolic process (GO:0046485)3.42751388
55negative regulation of Rho protein signal transduction (GO:0035024)3.35658159
56positive regulation of SMAD protein import into nucleus (GO:0060391)3.32802602
57preassembly of GPI anchor in ER membrane (GO:0016254)3.29881366
58sterol transport (GO:0015918)3.18992319
59cholesterol transport (GO:0030301)3.18992319
60nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.15489926
61regulation of response to osmotic stress (GO:0047484)3.15455961
62dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.13699866
63mannosylation (GO:0097502)3.12668507
64positive regulation of potassium ion transmembrane transport (GO:1901381)3.11423171
65nuclear pore complex assembly (GO:0051292)3.10415659
66telencephalon cell migration (GO:0022029)3.08537591
67replication fork processing (GO:0031297)3.08356774
68regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.08237721
69positive regulation of potassium ion transport (GO:0043268)3.07606416
70regulation of protein kinase A signaling (GO:0010738)3.06325467
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04273387
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.03536634
73behavioral response to nicotine (GO:0035095)2.99982067
74sphingosine metabolic process (GO:0006670)2.98824700
75regulation of mitotic spindle organization (GO:0060236)2.98470816
76sympathetic nervous system development (GO:0048485)2.97746411
77positive regulation of heart rate (GO:0010460)2.91503775
78gene silencing by RNA (GO:0031047)2.88957430
79forebrain cell migration (GO:0021885)2.86201313
80C-terminal protein amino acid modification (GO:0018410)2.85970608
81regulation of cell proliferation involved in kidney development (GO:1901722)2.84651926
82C-terminal protein lipidation (GO:0006501)2.83962759
83diol metabolic process (GO:0034311)2.83042331
84microtubule polymerization or depolymerization (GO:0031109)2.80517435
85pathway-restricted SMAD protein phosphorylation (GO:0060389)2.80378544
86central nervous system projection neuron axonogenesis (GO:0021952)2.79317031
87regulation of energy homeostasis (GO:2000505)2.73424417
88establishment of protein localization to vacuole (GO:0072666)2.71789688
89protein targeting to vacuole (GO:0006623)2.71789688
90protein targeting to lysosome (GO:0006622)2.71789688
91regulation of MHC class II biosynthetic process (GO:0045346)2.71376624
92olfactory bulb development (GO:0021772)2.71316306
93autophagic vacuole assembly (GO:0000045)2.69545339
94anatomical structure arrangement (GO:0048532)2.69364585
95C4-dicarboxylate transport (GO:0015740)2.68473652
96dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67082513
97regulation of potassium ion transmembrane transporter activity (GO:1901016)2.66387069
98protein localization to endosome (GO:0036010)15.1529377
99response to nerve growth factor (GO:1990089)10.4074343
100cellular response to nerve growth factor stimulus (GO:1990090)10.4074343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse7.56414134
2GBX2_23144817_ChIP-Seq_PC3_Human4.24007883
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.36116520
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.34056766
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.06957413
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.95480053
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66071327
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62491832
9TAF15_26573619_Chip-Seq_HEK293_Human2.59247927
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52857615
11EZH2_22144423_ChIP-Seq_EOC_Human2.52726902
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.42871878
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.37656456
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.33553054
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31505346
16EWS_26573619_Chip-Seq_HEK293_Human2.27266021
17IGF1R_20145208_ChIP-Seq_DFB_Human2.23786237
18ER_23166858_ChIP-Seq_MCF-7_Human2.09211542
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.07751864
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03406017
21TP53_16413492_ChIP-PET_HCT116_Human2.03221389
22CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95639873
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.88361335
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86072324
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82876769
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81891854
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.78078429
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.76455595
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75902556
30TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.75386074
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67593910
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67129012
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63683734
34P53_22387025_ChIP-Seq_ESCs_Mouse1.63327480
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.63174043
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.62872659
37CBP_20019798_ChIP-Seq_JUKART_Human1.56386174
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56386174
39STAT3_23295773_ChIP-Seq_U87_Human1.55394260
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54287071
41P300_19829295_ChIP-Seq_ESCs_Human1.53926167
42ZNF274_21170338_ChIP-Seq_K562_Hela1.50043026
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48426165
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46709343
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.46441776
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.40802050
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.39726293
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38053661
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.37179106
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36941250
51CMYC_18555785_Chip-Seq_ESCs_Mouse1.33899951
52CTCF_18555785_Chip-Seq_ESCs_Mouse1.33829442
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33206424
54SMAD4_21799915_ChIP-Seq_A2780_Human1.32256489
55TCF4_23295773_ChIP-Seq_U87_Human1.29376109
56RXR_22108803_ChIP-Seq_LS180_Human1.28998284
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28264669
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26489788
59FUS_26573619_Chip-Seq_HEK293_Human1.26001385
60LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25228513
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.24130016
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23208155
63VDR_22108803_ChIP-Seq_LS180_Human1.23105743
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23103206
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20493723
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18372434
67SOX2_19829295_ChIP-Seq_ESCs_Human1.17832171
68NANOG_19829295_ChIP-Seq_ESCs_Human1.17832171
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17615000
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17615000
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.16641432
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16103387
73TP53_18474530_ChIP-ChIP_U2OS_Human1.16051667
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15712403
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.14139235
76ETV1_20927104_ChIP-Seq_GIST48_Human1.13746092
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.12945875
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.09973596
79P300_18555785_Chip-Seq_ESCs_Mouse1.09778104
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.09733417
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09077125
82OCT4_18555785_Chip-Seq_ESCs_Mouse1.07983855
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05738478
84AR_25329375_ChIP-Seq_VCAP_Human1.05398308
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05045212
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01472431
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.01133434
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.00132274
89CJUN_26792858_Chip-Seq_BT549_Human0.99378559
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98951584
91NMYC_18555785_Chip-Seq_ESCs_Mouse0.98617387
92BCAT_22108803_ChIP-Seq_LS180_Human0.98484701
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98258372
94RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97561778
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97297379
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.96112620
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.94270958
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92383159
99TCF4_22108803_ChIP-Seq_LS180_Human0.91802380
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.91158441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation5.48290199
2MP0002234_abnormal_pharynx_morphology4.97215084
3MP0002249_abnormal_larynx_morphology4.52216380
4MP0004484_altered_response_of3.68068331
5MP0000569_abnormal_digit_pigmentation3.30543865
6MP0008260_abnormal_autophagy3.20909062
7MP0000049_abnormal_middle_ear2.97960910
8MP0000613_abnormal_salivary_gland2.97579056
9MP0002233_abnormal_nose_morphology2.73322387
10MP0000631_abnormal_neuroendocrine_gland2.54857052
11MP0000778_abnormal_nervous_system2.41487970
12MP0000427_abnormal_hair_cycle2.38366286
13MP0004782_abnormal_surfactant_physiolog1.98840636
14MP0000647_abnormal_sebaceous_gland1.97938790
15MP0002751_abnormal_autonomic_nervous1.95399819
16MP0005187_abnormal_penis_morphology1.88421662
17MP0002697_abnormal_eye_size1.88295156
18MP0003935_abnormal_craniofacial_develop1.81560978
19MP0004859_abnormal_synaptic_plasticity1.76583984
20MP0001293_anophthalmia1.75405582
21MP0002896_abnormal_bone_mineralization1.54894248
22MP0002184_abnormal_innervation1.49801670
23MP0002168_other_aberrant_phenotype1.47343924
24MP0008057_abnormal_DNA_replication1.45803211
25MP0003755_abnormal_palate_morphology1.44500727
26MP0003950_abnormal_plasma_membrane1.43465817
27MP0002734_abnormal_mechanical_nocicepti1.43132446
28MP0004270_analgesia1.43010577
29MP0002998_abnormal_bone_remodeling1.42060963
30MP0002109_abnormal_limb_morphology1.41221380
31MP0003567_abnormal_fetal_cardiomyocyte1.40151299
32MP0004811_abnormal_neuron_physiology1.39006572
33MP0001286_abnormal_eye_development1.38371973
34MP0000762_abnormal_tongue_morphology1.31809601
35MP0009250_abnormal_appendicular_skeleto1.31806972
36MP0001299_abnormal_eye_distance/1.29472123
37MP0001486_abnormal_startle_reflex1.25054923
38MP0009745_abnormal_behavioral_response1.23252199
39MP0005365_abnormal_bile_salt1.19284434
40MP0001485_abnormal_pinna_reflex1.19282774
41MP0002735_abnormal_chemical_nociception1.19127915
42MP0010386_abnormal_urinary_bladder1.16021085
43MP0002272_abnormal_nervous_system1.15407228
44MP0001765_abnormal_ion_homeostasis1.15092942
45MP0001986_abnormal_taste_sensitivity1.09193201
46MP0002177_abnormal_outer_ear1.09045869
47MP0003195_calcinosis1.06914774
48MP0002095_abnormal_skin_pigmentation1.05181008
49MP0004885_abnormal_endolymph1.03562363
50MP0002116_abnormal_craniofacial_bone1.02709627
51MP0002733_abnormal_thermal_nociception1.02187759
52MP0005220_abnormal_exocrine_pancreas1.02131362
53MP0005386_behavior/neurological_phenoty1.01162587
54MP0004924_abnormal_behavior1.01162587
55MP0000432_abnormal_head_morphology1.00801188
56MP0004134_abnormal_chest_morphology1.00474834
57MP0000163_abnormal_cartilage_morphology0.98409638
58MP0009046_muscle_twitch0.98192518
59MP0002638_abnormal_pupillary_reflex0.97795598
60MP0005165_increased_susceptibility_to0.96671457
61MP0002152_abnormal_brain_morphology0.96611241
62MP0008875_abnormal_xenobiotic_pharmacok0.96105004
63MP0001529_abnormal_vocalization0.95677495
64MP0002063_abnormal_learning/memory/cond0.95341283
65MP0003880_abnormal_central_pattern0.94888714
66MP0002882_abnormal_neuron_morphology0.94435257
67MP0003861_abnormal_nervous_system0.93678292
68MP0002127_abnormal_cardiovascular_syste0.91925694
69MP0000534_abnormal_ureter_morphology0.91656994
70MP0004742_abnormal_vestibular_system0.91511504
71MP0003045_fibrosis0.90253189
72MP0003937_abnormal_limbs/digits/tail_de0.86302674
73MP0005083_abnormal_biliary_tract0.86106851
74MP0001270_distended_abdomen0.85770877
75MP0003119_abnormal_digestive_system0.85354118
76MP0001764_abnormal_homeostasis0.85233661
77MP0005636_abnormal_mineral_homeostasis0.84167725
78MP0002254_reproductive_system_inflammat0.84074366
79MP0006082_CNS_inflammation0.80754100
80MP0006035_abnormal_mitochondrial_morpho0.80294618
81MP0001970_abnormal_pain_threshold0.77676301
82MP0003942_abnormal_urinary_system0.77403168
83MP0005670_abnormal_white_adipose0.77256290
84MP0005645_abnormal_hypothalamus_physiol0.74225542
85MP0008775_abnormal_heart_ventricle0.73950601
86MP0008872_abnormal_physiological_respon0.73643165
87MP0008569_lethality_at_weaning0.73458367
88MP0000639_abnormal_adrenal_gland0.72891577
89MP0000470_abnormal_stomach_morphology0.72783441
90MP0002102_abnormal_ear_morphology0.72340149
91MP0001915_intracranial_hemorrhage0.71596267
92MP0002064_seizures0.70164437
93MP0003635_abnormal_synaptic_transmissio0.70086428
94MP0003938_abnormal_ear_development0.69926389
95MP0003943_abnormal_hepatobiliary_system0.69837867
96MP0002653_abnormal_ependyma_morphology0.69159376
97MP0003137_abnormal_impulse_conducting0.68554302
98MP0003186_abnormal_redox_activity0.68466794
99MP0002971_abnormal_brown_adipose0.67832588
100MP0002837_dystrophic_cardiac_calcinosis0.65856384

Predicted human phenotypes

RankGene SetZ-score
1Long nose (HP:0003189)7.84875298
2Conical tooth (HP:0000698)7.54366952
3Reduced antithrombin III activity (HP:0001976)7.18410204
4Broad-based gait (HP:0002136)6.53863998
5Neoplasm of the oral cavity (HP:0100649)5.80186315
6Type I transferrin isoform profile (HP:0003642)5.16551429
7Oligodontia (HP:0000677)4.97930630
8Abnormality of the intrinsic pathway (HP:0010989)4.78355480
9Progressive inability to walk (HP:0002505)4.64597613
10Bulbous nose (HP:0000414)3.88008198
11Inability to walk (HP:0002540)3.73686648
12Preaxial foot polydactyly (HP:0001841)3.68515178
13Abnormality of lateral ventricle (HP:0030047)3.66975224
14Absent eyebrow (HP:0002223)3.55187001
15Exotropia (HP:0000577)3.52755652
16Hyperventilation (HP:0002883)3.49173192
17Abnormal protein glycosylation (HP:0012346)3.39045982
18Abnormal glycosylation (HP:0012345)3.39045982
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.39045982
20Abnormal protein N-linked glycosylation (HP:0012347)3.39045982
21Abnormality of the parathyroid morphology (HP:0011766)3.27975802
22Abnormality of the labia minora (HP:0012880)3.14777847
23Heterotopia (HP:0002282)3.11901968
24Arterial tortuosity (HP:0005116)3.09609230
25Morphological abnormality of the middle ear (HP:0008609)2.96657286
26Short 4th metacarpal (HP:0010044)2.88798422
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88798422
28Amyotrophic lateral sclerosis (HP:0007354)2.88136922
29Lissencephaly (HP:0001339)2.86229336
30Acute lymphatic leukemia (HP:0006721)2.79188855
31Diastasis recti (HP:0001540)2.79112430
32Pachygyria (HP:0001302)2.77807570
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75900516
34Abnormality of the pubic bones (HP:0003172)2.72487158
35Vascular tortuosity (HP:0004948)2.61485382
36Lower limb amyotrophy (HP:0007210)2.60976932
37Cerebral aneurysm (HP:0004944)2.59291403
38Truncal ataxia (HP:0002078)2.56178064
39Bilateral microphthalmos (HP:0007633)2.55139382
40Fine hair (HP:0002213)2.54380679
41Spastic tetraparesis (HP:0001285)2.53788374
42Limb ataxia (HP:0002070)2.49000519
43Capillary hemangiomas (HP:0005306)2.40595842
44Hepatoblastoma (HP:0002884)2.40333236
45Hypoplastic ischia (HP:0003175)2.39746561
46Fair hair (HP:0002286)2.35138198
47Hip contracture (HP:0003273)2.34036606
48Anal stenosis (HP:0002025)2.29763232
49Abnormality of the lower motor neuron (HP:0002366)2.28493880
50Lower limb muscle weakness (HP:0007340)2.27664100
51Abnormality of the ischium (HP:0003174)2.25851357
52Intention tremor (HP:0002080)2.25558901
53Severe Myopia (HP:0011003)2.22012979
54Smooth philtrum (HP:0000319)2.21392734
55Bifid tongue (HP:0010297)2.21138954
56Absent speech (HP:0001344)2.20800454
57Metaphyseal dysplasia (HP:0100255)2.18860710
58Abnormality of the corticospinal tract (HP:0002492)2.17425931
59Aortic aneurysm (HP:0004942)2.10402405
60Gaze-evoked nystagmus (HP:0000640)2.09311155
61Widely spaced teeth (HP:0000687)2.07383030
62Attenuation of retinal blood vessels (HP:0007843)2.06634507
63Type II lissencephaly (HP:0007260)2.05422840
64Febrile seizures (HP:0002373)2.04535692
65Pancreatic cysts (HP:0001737)2.04097338
66Clubbing of toes (HP:0100760)2.01337639
67Spastic gait (HP:0002064)2.00315028
68Muscular hypotonia of the trunk (HP:0008936)1.98699498
69Abnormality of ocular smooth pursuit (HP:0000617)1.98486224
70Abnormality of the 4th metacarpal (HP:0010012)1.96073930
71Facial cleft (HP:0002006)1.95317953
72Abnormal pancreas size (HP:0012094)1.92986616
73Abnormality of macular pigmentation (HP:0008002)1.92756593
74Uterine leiomyosarcoma (HP:0002891)1.92184769
75Leiomyosarcoma (HP:0100243)1.92184769
76Basal cell carcinoma (HP:0002671)1.92183006
77Abnormality of abdominal situs (HP:0011620)1.92078259
78Abdominal situs inversus (HP:0003363)1.92078259
79Striae distensae (HP:0001065)1.91476560
80Interstitial pulmonary disease (HP:0006530)1.91412752
81Generalized hypopigmentation of hair (HP:0011358)1.91406032
82Ankle clonus (HP:0011448)1.88096053
83Achilles tendon contracture (HP:0001771)1.87769143
84Neonatal hypoglycemia (HP:0001998)1.84457425
85Protruding tongue (HP:0010808)1.84387729
86Pseudobulbar signs (HP:0002200)1.83801850
87Abnormality of the Achilles tendon (HP:0005109)1.77799230
88Spastic paraplegia (HP:0001258)1.76047661
89Midline defect of the nose (HP:0004122)1.74834885
90Poor eye contact (HP:0000817)1.73939583
91Drooling (HP:0002307)1.71910104
92Focal motor seizures (HP:0011153)1.71455440
93Renal cortical cysts (HP:0000803)1.71126666
94Urinary urgency (HP:0000012)1.69692259
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69528719
96Overlapping toe (HP:0001845)1.69084203
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.65638186
98Cleft eyelid (HP:0000625)1.65633525
99Poor speech (HP:0002465)1.64291472
100Accelerated skeletal maturation (HP:0005616)1.63464144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC42BPA5.81816858
2BCR5.79708314
3TGFBR25.28749925
4TAOK34.43188839
5TNIK3.81495355
6LATS13.72648760
7DMPK3.16729878
8CDK32.68986409
9NUAK12.67422167
10DYRK32.18447842
11WNK12.17595669
12HCK2.12438451
13SIK22.02782025
14TLK11.79918264
15EPHA41.74173410
16SGK21.72940904
17PDGFRA1.69999196
18STK381.50590625
19CAMKK21.50115217
20FRK1.47189475
21ZAK1.28792484
22MAP3K91.28469728
23CASK1.26763926
24CAMK41.26745602
25STK31.23931613
26LCK1.16362281
27CAMK2A1.15613548
28SGK31.15261146
29GRK11.04077771
30SGK4941.03653494
31SGK2231.03653494
32ROCK11.02482046
33CAMK1D0.90592569
34EIF2AK10.87401358
35RPS6KA40.81784774
36TRIM280.78119852
37ADRBK20.78062609
38CLK10.77384638
39ABL10.72756965
40GRK50.72255004
41PRKDC0.70668786
42IRAK10.67446980
43PDGFRB0.63421346
44NLK0.60809936
45TXK0.58911436
46MST40.56959004
47ADRBK10.56588135
48PKN20.55575516
49IKBKE0.55286994
50CAMK2B0.54349668
51IRAK40.53959777
52WNK30.53337688
53MELK0.52532654
54CAMK1G0.52062208
55OXSR10.52053127
56STK390.50696156
57ATM0.48613306
58EPHB10.47691883
59EIF2AK30.46013441
60DYRK1A0.45302372
61IRAK20.42359912
62PRKCH0.41263038
63TEC0.41103752
64ICK0.40910076
65SIK30.39051522
66RPS6KA50.38398388
67CAMKK10.37976402
68NTRK30.37739687
69STK110.37593018
70PIK3CA0.37185978
71MARK10.36015091
72STK40.34590304
73PRKCE0.32610337
74RPS6KA60.32353825
75RPS6KC10.31583852
76RPS6KL10.31583852
77RPS6KA10.31360295
78ITK0.29460602
79PAK30.29396975
80CAMK10.28677791
81CAMK2D0.28579192
82PRKCG0.27488056
83NTRK20.25999991
84INSRR0.25196904
85MAP3K70.24548315
86SGK10.24234114
87BTK0.22387273
88MAPK140.21731752
89PRKCB0.20717807
90PTK20.20070204
91CDK120.20017699
92AKT30.19633222
93GSK3B0.18798845
94TRPM70.17491364
95KIT0.16725714
96PRKCQ0.15903545
97PINK10.15708103
98EGFR0.15485763
99PKN10.14691723
100MET0.14669580

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009007.22728526
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.65034620
3Regulation of autophagy_Homo sapiens_hsa041403.08725729
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.62865553
5Taste transduction_Homo sapiens_hsa047422.46455473
6N-Glycan biosynthesis_Homo sapiens_hsa005102.28203641
7Morphine addiction_Homo sapiens_hsa050322.23005811
8Non-homologous end-joining_Homo sapiens_hsa034502.09296946
9Axon guidance_Homo sapiens_hsa043601.99253442
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81972101
11Glutamatergic synapse_Homo sapiens_hsa047241.78585487
12ABC transporters_Homo sapiens_hsa020101.70805730
13Circadian entrainment_Homo sapiens_hsa047131.67586811
14Nicotine addiction_Homo sapiens_hsa050331.55347076
15Adherens junction_Homo sapiens_hsa045201.50520887
16Renin secretion_Homo sapiens_hsa049241.46072411
17Colorectal cancer_Homo sapiens_hsa052101.39170109
18Insulin secretion_Homo sapiens_hsa049111.38678205
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37484745
20GABAergic synapse_Homo sapiens_hsa047271.32108277
21Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30460659
22Dopaminergic synapse_Homo sapiens_hsa047281.28788782
23ErbB signaling pathway_Homo sapiens_hsa040121.26940347
24RNA degradation_Homo sapiens_hsa030181.26652902
25Cholinergic synapse_Homo sapiens_hsa047251.25283926
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12127995
27Alcoholism_Homo sapiens_hsa050341.11834526
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09653353
29Systemic lupus erythematosus_Homo sapiens_hsa053221.08500215
30Sphingolipid metabolism_Homo sapiens_hsa006001.06853255
31Prolactin signaling pathway_Homo sapiens_hsa049171.04073702
32Salivary secretion_Homo sapiens_hsa049701.02607157
33Fanconi anemia pathway_Homo sapiens_hsa034601.01834333
34Osteoclast differentiation_Homo sapiens_hsa043800.98720430
35Olfactory transduction_Homo sapiens_hsa047400.97860855
36Ether lipid metabolism_Homo sapiens_hsa005650.91424422
37Pancreatic secretion_Homo sapiens_hsa049720.90965076
38Type II diabetes mellitus_Homo sapiens_hsa049300.88631918
39Calcium signaling pathway_Homo sapiens_hsa040200.86263515
40Amphetamine addiction_Homo sapiens_hsa050310.85922217
41Phototransduction_Homo sapiens_hsa047440.80732196
42Ovarian steroidogenesis_Homo sapiens_hsa049130.79839259
43Nitrogen metabolism_Homo sapiens_hsa009100.77025197
44Ras signaling pathway_Homo sapiens_hsa040140.74702344
45TGF-beta signaling pathway_Homo sapiens_hsa043500.74305780
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72768455
47B cell receptor signaling pathway_Homo sapiens_hsa046620.72397801
48cAMP signaling pathway_Homo sapiens_hsa040240.71589350
49Linoleic acid metabolism_Homo sapiens_hsa005910.65417738
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61885562
51Chemokine signaling pathway_Homo sapiens_hsa040620.60961042
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59882580
53Serotonergic synapse_Homo sapiens_hsa047260.59833260
54Vitamin B6 metabolism_Homo sapiens_hsa007500.58801773
55VEGF signaling pathway_Homo sapiens_hsa043700.58624343
56Propanoate metabolism_Homo sapiens_hsa006400.58183457
57Glucagon signaling pathway_Homo sapiens_hsa049220.58122971
58mTOR signaling pathway_Homo sapiens_hsa041500.57277950
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55450838
60Pancreatic cancer_Homo sapiens_hsa052120.54494145
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.54390157
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53907728
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.53618088
64Tight junction_Homo sapiens_hsa045300.52685935
65T cell receptor signaling pathway_Homo sapiens_hsa046600.52112293
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51949172
67Renal cell carcinoma_Homo sapiens_hsa052110.51350091
68Gastric acid secretion_Homo sapiens_hsa049710.49596821
69Selenocompound metabolism_Homo sapiens_hsa004500.48212075
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48165583
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.46078959
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45701927
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45324081
74MAPK signaling pathway_Homo sapiens_hsa040100.45308759
75Fatty acid biosynthesis_Homo sapiens_hsa000610.44111027
76Basal cell carcinoma_Homo sapiens_hsa052170.43131774
77Choline metabolism in cancer_Homo sapiens_hsa052310.42637053
78Long-term potentiation_Homo sapiens_hsa047200.42054059
79Dorso-ventral axis formation_Homo sapiens_hsa043200.41695954
80Caffeine metabolism_Homo sapiens_hsa002320.39485106
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39112030
82Melanogenesis_Homo sapiens_hsa049160.39021597
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.38793309
84Wnt signaling pathway_Homo sapiens_hsa043100.38474258
85Hedgehog signaling pathway_Homo sapiens_hsa043400.38090798
86Inositol phosphate metabolism_Homo sapiens_hsa005620.36876550
87Rap1 signaling pathway_Homo sapiens_hsa040150.35528384
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34967488
89Hippo signaling pathway_Homo sapiens_hsa043900.33640496
90Tuberculosis_Homo sapiens_hsa051520.32099348
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31608643
92Measles_Homo sapiens_hsa051620.31288618
93Pathways in cancer_Homo sapiens_hsa052000.31194168
94Circadian rhythm_Homo sapiens_hsa047100.30077536
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29917244
96Endocytosis_Homo sapiens_hsa041440.28983961
97Starch and sucrose metabolism_Homo sapiens_hsa005000.28663255
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27371334
99Cocaine addiction_Homo sapiens_hsa050300.25592238
100Oxytocin signaling pathway_Homo sapiens_hsa049210.25460520

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