RPL13P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.67884213
2viral transcription (GO:0019083)8.54855462
3translational termination (GO:0006415)8.09177109
4maturation of SSU-rRNA (GO:0030490)7.51022905
5ribosomal small subunit biogenesis (GO:0042274)7.11404903
6translational elongation (GO:0006414)6.77479124
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.75275382
8protein targeting to ER (GO:0045047)6.65617550
9cotranslational protein targeting to membrane (GO:0006613)6.64505306
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.37529676
11protein localization to endoplasmic reticulum (GO:0070972)6.28307001
12cellular protein complex disassembly (GO:0043624)6.13452021
13viral life cycle (GO:0019058)6.07618282
14ATP synthesis coupled proton transport (GO:0015986)5.77604790
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.77604790
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.77156887
17protein complex disassembly (GO:0043241)5.22473658
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14266854
19behavioral response to nicotine (GO:0035095)5.10282000
20chaperone-mediated protein transport (GO:0072321)5.02051375
21translational initiation (GO:0006413)4.92335865
22macromolecular complex disassembly (GO:0032984)4.92289789
23protein neddylation (GO:0045116)4.84575029
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.59702716
25cell proliferation in forebrain (GO:0021846)4.51153172
26protein targeting to membrane (GO:0006612)4.49833151
27ribosomal large subunit biogenesis (GO:0042273)4.35083074
28respiratory electron transport chain (GO:0022904)4.12547004
29electron transport chain (GO:0022900)4.10235447
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.09083100
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.09083100
32NADH dehydrogenase complex assembly (GO:0010257)4.09083100
33protein complex biogenesis (GO:0070271)3.99927110
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.98911944
35translation (GO:0006412)3.94912891
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85991470
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.84163070
38mRNA catabolic process (GO:0006402)3.75905134
39DNA deamination (GO:0045006)3.66133450
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55172675
41response to pheromone (GO:0019236)3.48023631
42mitochondrial respiratory chain complex assembly (GO:0033108)3.44628170
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42211892
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42211892
45RNA catabolic process (GO:0006401)3.36349536
46pyrimidine nucleobase catabolic process (GO:0006208)3.34283561
47somite development (GO:0061053)3.24485169
48nonmotile primary cilium assembly (GO:0035058)3.23415189
49axonemal dynein complex assembly (GO:0070286)3.20731908
50ATP biosynthetic process (GO:0006754)3.19138544
51cellular component biogenesis (GO:0044085)3.12576220
52hydrogen ion transmembrane transport (GO:1902600)3.11967687
53negative regulation of appetite (GO:0032099)3.11693849
54negative regulation of response to food (GO:0032096)3.11693849
55protein polyglutamylation (GO:0018095)3.08172947
56sequestering of actin monomers (GO:0042989)3.07727276
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.06952053
58substrate-independent telencephalic tangential migration (GO:0021826)3.06952053
59ribonucleoprotein complex biogenesis (GO:0022613)3.04843765
60water-soluble vitamin biosynthetic process (GO:0042364)3.01654772
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01104207
62establishment of protein localization to membrane (GO:0090150)3.00330016
63tongue development (GO:0043586)2.98438652
64regulation of cilium movement (GO:0003352)2.94847582
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92997481
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90230370
67positive regulation of T cell apoptotic process (GO:0070234)2.87987186
68spinal cord association neuron differentiation (GO:0021527)2.83871150
69cytidine deamination (GO:0009972)2.81790637
70cytidine metabolic process (GO:0046087)2.81790637
71cytidine catabolic process (GO:0006216)2.81790637
72protein targeting (GO:0006605)2.81586956
73proton transport (GO:0015992)2.78057062
74preassembly of GPI anchor in ER membrane (GO:0016254)2.77193503
75positive regulation of prostaglandin secretion (GO:0032308)2.76328118
76hydrogen transport (GO:0006818)2.74653757
77negative regulation of heart rate (GO:0010459)2.74064238
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72491258
79positive regulation of protein homooligomerization (GO:0032464)2.70519536
80negative regulation of telomere maintenance (GO:0032205)2.64202294
81transmission of nerve impulse (GO:0019226)2.63256607
82regulation of cellular respiration (GO:0043457)2.60357845
83GPI anchor metabolic process (GO:0006505)2.60336808
84nucleobase catabolic process (GO:0046113)2.59760535
85ribonucleoside triphosphate biosynthetic process (GO:0009201)2.58506981
86establishment of protein localization to organelle (GO:0072594)2.56359417
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.53765906
88protein-cofactor linkage (GO:0018065)2.53127143
89epithelial cilium movement (GO:0003351)2.50744788
90synaptic transmission, cholinergic (GO:0007271)2.50111804
91seminiferous tubule development (GO:0072520)2.48438080
92protein localization to membrane (GO:0072657)2.45423196
93positive regulation of fatty acid transport (GO:2000193)2.44553651
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44153056
95GTP biosynthetic process (GO:0006183)2.43995475
96positive regulation of icosanoid secretion (GO:0032305)2.42185969
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39885570
98hypothalamus development (GO:0021854)2.39658786
99GPI anchor biosynthetic process (GO:0006506)2.39555577
100pyrimidine ribonucleoside catabolic process (GO:0046133)2.37491642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.42643658
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.67261691
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.48959037
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87437302
5VDR_22108803_ChIP-Seq_LS180_Human2.69022911
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63286217
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.58863220
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41053725
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35847474
10IRF1_19129219_ChIP-ChIP_H3396_Human2.15477554
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12111383
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.02681229
13ZNF274_21170338_ChIP-Seq_K562_Hela2.00769891
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.97607713
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.94042719
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.88544037
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87218262
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85415323
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.83800723
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.79245368
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78668252
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74500146
23MYC_18940864_ChIP-ChIP_HL60_Human1.66744390
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62704929
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61936273
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47226271
27REST_21632747_ChIP-Seq_MESCs_Mouse1.46989936
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44393189
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43390352
30IGF1R_20145208_ChIP-Seq_DFB_Human1.41096563
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40338582
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39377564
33ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39207758
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37795305
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37795305
36CTCF_27219007_Chip-Seq_Bcells_Human1.35684292
37ERA_21632823_ChIP-Seq_H3396_Human1.35579913
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35461085
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.35389430
40RNF2_27304074_Chip-Seq_NSC_Mouse1.35145922
41TP53_22573176_ChIP-Seq_HFKS_Human1.34263153
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34099705
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.32719661
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28873719
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27168868
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26288951
47TAF2_19829295_ChIP-Seq_ESCs_Human1.26167550
48VDR_23849224_ChIP-Seq_CD4+_Human1.25300174
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24843420
50NANOG_20526341_ChIP-Seq_ESCs_Human1.24727795
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24224091
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.23864257
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23654680
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23581088
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21969631
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21323122
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20750763
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.20299449
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18983625
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.17418798
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16973120
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14651896
63NCOR_22424771_ChIP-Seq_293T_Human1.13852102
64BCL6_27268052_Chip-Seq_Bcells_Human1.13453712
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.12670281
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11544333
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10962357
68TTF2_22483619_ChIP-Seq_HELA_Human1.10349586
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07983748
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06132981
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.04815686
72CTCF_20526341_ChIP-Seq_ESCs_Human1.02907305
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.02683647
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01638771
75SA1_27219007_Chip-Seq_Bcells_Human1.00257313
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00230541
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99994689
78FOXP3_21729870_ChIP-Seq_TREG_Human0.98259424
79POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98241015
80RING1B_27294783_Chip-Seq_ESCs_Mouse0.97731661
81AR_20517297_ChIP-Seq_VCAP_Human0.97486121
82MYC_19829295_ChIP-Seq_ESCs_Human0.97167385
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.97066907
84TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95448294
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94596110
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93745366
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.92431236
88BP1_19119308_ChIP-ChIP_Hs578T_Human0.92384226
89FUS_26573619_Chip-Seq_HEK293_Human0.91321520
90E2F1_20622854_ChIP-Seq_HELA_Human0.90239723
91EWS_26573619_Chip-Seq_HEK293_Human0.89004147
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.88804296
93GATA3_21867929_ChIP-Seq_TH1_Mouse0.88643288
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88210260
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.87033059
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86134258
97XRN2_22483619_ChIP-Seq_HELA_Human0.85812993
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.85656036
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85537241
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85258122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.82712793
2MP0006292_abnormal_olfactory_placode4.19667011
3MP0003787_abnormal_imprinting3.02546291
4MP0008789_abnormal_olfactory_epithelium2.47138777
5MP0005377_hearing/vestibular/ear_phenot2.45544530
6MP0003878_abnormal_ear_physiology2.45544530
7MP0003123_paternal_imprinting2.31034264
8MP0002653_abnormal_ependyma_morphology2.27148062
9MP0003122_maternal_imprinting2.26583758
10MP0004142_abnormal_muscle_tone2.26070633
11MP0004885_abnormal_endolymph2.21535261
12MP0008877_abnormal_DNA_methylation2.18533099
13MP0005394_taste/olfaction_phenotype2.09572403
14MP0005499_abnormal_olfactory_system2.09572403
15MP0002837_dystrophic_cardiac_calcinosis1.98158112
16MP0001485_abnormal_pinna_reflex1.97924532
17MP0002163_abnormal_gland_morphology1.95574484
18MP0005646_abnormal_pituitary_gland1.92997612
19MP0003646_muscle_fatigue1.90714667
20MP0003136_yellow_coat_color1.85624744
21MP0003121_genomic_imprinting1.84139359
22MP0005551_abnormal_eye_electrophysiolog1.69786099
23MP0001968_abnormal_touch/_nociception1.65913179
24MP0001529_abnormal_vocalization1.63352719
25MP0002102_abnormal_ear_morphology1.60731301
26MP0000778_abnormal_nervous_system1.56731087
27MP0006072_abnormal_retinal_apoptosis1.54669821
28MP0003879_abnormal_hair_cell1.54433727
29MP0005671_abnormal_response_to1.49628877
30MP0002272_abnormal_nervous_system1.48457179
31MP0000049_abnormal_middle_ear1.48273060
32MP0001905_abnormal_dopamine_level1.45237616
33MP0001986_abnormal_taste_sensitivity1.41614186
34MP0006276_abnormal_autonomic_nervous1.39458843
35MP0001440_abnormal_grooming_behavior1.35965438
36MP0002876_abnormal_thyroid_physiology1.34998309
37MP0004742_abnormal_vestibular_system1.34882263
38MP0001293_anophthalmia1.31239928
39MP0000631_abnormal_neuroendocrine_gland1.30299848
40MP0005389_reproductive_system_phenotype1.27724145
41MP0001984_abnormal_olfaction1.26627593
42MP0002138_abnormal_hepatobiliary_system1.26203726
43MP0002733_abnormal_thermal_nociception1.24111619
44MP0002638_abnormal_pupillary_reflex1.23944409
45MP0005423_abnormal_somatic_nervous1.23826019
46MP0002160_abnormal_reproductive_system1.22393005
47MP0005379_endocrine/exocrine_gland_phen1.21395591
48MP0004133_heterotaxia1.21001436
49MP0001970_abnormal_pain_threshold1.20797040
50MP0004147_increased_porphyrin_level1.19928387
51MP0001919_abnormal_reproductive_system1.18779015
52MP0009745_abnormal_behavioral_response1.16507639
53MP0003880_abnormal_central_pattern1.14391801
54MP0001188_hyperpigmentation1.13935343
55MP0008872_abnormal_physiological_respon1.12587479
56MP0002557_abnormal_social/conspecific_i1.11716452
57MP0009053_abnormal_anal_canal1.11413816
58MP0002095_abnormal_skin_pigmentation1.11184189
59MP0005195_abnormal_posterior_eye1.09420103
60MP0000026_abnormal_inner_ear1.08702368
61MP0002234_abnormal_pharynx_morphology1.05937289
62MP0004130_abnormal_muscle_cell1.05372534
63MP0002752_abnormal_somatic_nervous1.03936414
64MP0009046_muscle_twitch1.03525323
65MP0001963_abnormal_hearing_physiology1.03438020
66MP0002736_abnormal_nociception_after1.03407032
67MP0008775_abnormal_heart_ventricle0.99085749
68MP0003938_abnormal_ear_development0.98712628
69MP0002734_abnormal_mechanical_nocicepti0.97545272
70MP0004859_abnormal_synaptic_plasticity0.95600155
71MP0008875_abnormal_xenobiotic_pharmacok0.94830869
72MP0002572_abnormal_emotion/affect_behav0.93718941
73MP0003011_delayed_dark_adaptation0.92696604
74MP0002184_abnormal_innervation0.91771357
75MP0000955_abnormal_spinal_cord0.90859622
76MP0000566_synostosis0.89568111
77MP0005253_abnormal_eye_physiology0.88196036
78MP0003635_abnormal_synaptic_transmissio0.87395268
79MP0002063_abnormal_learning/memory/cond0.85885766
80MP0003195_calcinosis0.85652739
81MP0003315_abnormal_perineum_morphology0.85321678
82MP0004145_abnormal_muscle_electrophysio0.84647714
83MP0001486_abnormal_startle_reflex0.82579336
84MP0005645_abnormal_hypothalamus_physiol0.81668739
85MP0000230_abnormal_systemic_arterial0.81304992
86MP0002064_seizures0.78292017
87MP0001502_abnormal_circadian_rhythm0.78045121
88MP0008995_early_reproductive_senescence0.77961307
89MP0002938_white_spotting0.76156439
90MP0005084_abnormal_gallbladder_morpholo0.74967840
91MP0002067_abnormal_sensory_capabilities0.73988363
92MP0004858_abnormal_nervous_system0.73096007
93MP0000372_irregular_coat_pigmentation0.71335511
94MP0002882_abnormal_neuron_morphology0.70185600
95MP0001348_abnormal_lacrimal_gland0.67431633
96MP0000427_abnormal_hair_cycle0.66815697
97MP0002822_catalepsy0.66303641
98MP0009250_abnormal_appendicular_skeleto0.65691578
99MP0005410_abnormal_fertilization0.64306103
100MP0002210_abnormal_sex_determination0.64255805

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.66477085
2Abnormality of cells of the erythroid lineage (HP:0012130)5.14787066
3Acute necrotizing encephalopathy (HP:0006965)4.75643806
4Abnormal mitochondria in muscle tissue (HP:0008316)4.29708442
5Abnormal number of erythroid precursors (HP:0012131)4.27351665
6Acute encephalopathy (HP:0006846)4.09418391
7Macrocytic anemia (HP:0001972)4.02525200
8Progressive macrocephaly (HP:0004481)3.91255661
9Mitochondrial inheritance (HP:0001427)3.83071976
10Pallor (HP:0000980)3.73384548
11Septo-optic dysplasia (HP:0100842)3.57773052
12Pancreatic fibrosis (HP:0100732)3.36800690
13Molar tooth sign on MRI (HP:0002419)3.33105014
14Abnormality of midbrain morphology (HP:0002418)3.33105014
153-Methylglutaconic aciduria (HP:0003535)3.22602016
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.20273506
17True hermaphroditism (HP:0010459)3.20082917
18Increased CSF lactate (HP:0002490)3.17371370
19Cerebral edema (HP:0002181)3.09971942
20Pancreatic cysts (HP:0001737)3.07601000
21Hepatocellular necrosis (HP:0001404)3.02149805
22Increased hepatocellular lipid droplets (HP:0006565)2.88623683
23Medial flaring of the eyebrow (HP:0010747)2.85718008
24Absent thumb (HP:0009777)2.69643901
25Hyperglycinemia (HP:0002154)2.66679032
26Lipid accumulation in hepatocytes (HP:0006561)2.62770714
27Type II lissencephaly (HP:0007260)2.62739359
28Abnormal hemoglobin (HP:0011902)2.61620086
29Optic disc pallor (HP:0000543)2.59600045
30Rib fusion (HP:0000902)2.56587479
31Hepatic necrosis (HP:0002605)2.55036229
32Sclerocornea (HP:0000647)2.53892731
33Abnormal rod and cone electroretinograms (HP:0008323)2.50518797
34Myokymia (HP:0002411)2.50275789
35Congenital stationary night blindness (HP:0007642)2.48310577
36Renal Fanconi syndrome (HP:0001994)2.48039238
37Gait imbalance (HP:0002141)2.46979826
38Abnormality of DNA repair (HP:0003254)2.45310422
39Partial duplication of thumb phalanx (HP:0009944)2.44044413
40Agitation (HP:0000713)2.43842140
41Nephronophthisis (HP:0000090)2.43105322
42Abnormal ciliary motility (HP:0012262)2.42887923
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.42346277
44Absent/shortened dynein arms (HP:0200106)2.42346277
45Increased intramyocellular lipid droplets (HP:0012240)2.39704132
46Stenosis of the external auditory canal (HP:0000402)2.34731585
47Congenital primary aphakia (HP:0007707)2.33034092
48Type 2 muscle fiber atrophy (HP:0003554)2.31335448
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.27261089
50Cystic liver disease (HP:0006706)2.23873975
51Anencephaly (HP:0002323)2.23766922
52Pendular nystagmus (HP:0012043)2.19518203
53Asplenia (HP:0001746)2.17656376
54Nephrogenic diabetes insipidus (HP:0009806)2.17223660
55Depressed nasal ridge (HP:0000457)2.13120605
56Abnormal respiratory motile cilium physiology (HP:0012261)2.12956295
57Partial duplication of the phalanx of hand (HP:0009999)2.12361682
58Hyperthyroidism (HP:0000836)2.10266615
59Optic nerve hypoplasia (HP:0000609)2.10017472
60Maternal diabetes (HP:0009800)2.07768957
61Congenital, generalized hypertrichosis (HP:0004540)2.04959288
62Elevated erythrocyte sedimentation rate (HP:0003565)2.04873642
63Anomalous pulmonary venous return (HP:0010772)2.01876028
64Hypoplasia of the radius (HP:0002984)2.01835168
65Lactic acidosis (HP:0003128)2.01267141
66Muscle fiber atrophy (HP:0100295)2.01179368
67Male pseudohermaphroditism (HP:0000037)2.00875370
68Abnormal respiratory motile cilium morphology (HP:0005938)2.00547355
69Abnormal respiratory epithelium morphology (HP:0012253)2.00547355
70Cerebellar dysplasia (HP:0007033)2.00238631
71Increased muscle lipid content (HP:0009058)2.00157777
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99815128
73Abnormality of the labia minora (HP:0012880)1.98829134
74Leukodystrophy (HP:0002415)1.98374689
75Hypoplasia of the ulna (HP:0003022)1.97942122
76Postaxial foot polydactyly (HP:0001830)1.97023693
77Adrenal hypoplasia (HP:0000835)1.96854960
78Abnormality of the renal medulla (HP:0100957)1.94806579
79Absent septum pellucidum (HP:0001331)1.94221262
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93739684
81Increased serum lactate (HP:0002151)1.92769057
82Anophthalmia (HP:0000528)1.91508715
83Forearm undergrowth (HP:0009821)1.87905461
84Triphalangeal thumb (HP:0001199)1.85890595
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84240139
86Abolished electroretinogram (ERG) (HP:0000550)1.84217343
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82222382
88Methylmalonic acidemia (HP:0002912)1.79243965
89Vaginal atresia (HP:0000148)1.78378971
90Exertional dyspnea (HP:0002875)1.77999037
91Abnormality of magnesium homeostasis (HP:0004921)1.76843636
92Rectal fistula (HP:0100590)1.76524075
93Rectovaginal fistula (HP:0000143)1.76524075
94Abnormality of reticulocytes (HP:0004312)1.74850103
95Abnormality of the renal cortex (HP:0011035)1.73945149
96Decreased central vision (HP:0007663)1.73654554
97Abnormal drinking behavior (HP:0030082)1.73531748
98Polydipsia (HP:0001959)1.73531748
99Genital tract atresia (HP:0001827)1.73247387
100Exercise intolerance (HP:0003546)1.71252842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.98546395
2CDK193.30765518
3PIK3CA3.30154245
4STK163.24413385
5TLK12.62881337
6WNK42.56228728
7ADRBK22.34029264
8TIE12.12164172
9DYRK21.99636368
10GRK11.96021070
11PINK11.95397595
12ZAK1.90518287
13ARAF1.58941477
14MAP4K21.54067271
15TAOK31.46013918
16MAP2K71.44858148
17MAP3K91.43657507
18NTRK21.43645635
19PASK1.42575163
20KDR1.41269322
21TXK1.33278578
22FRK1.29189038
23BRAF1.28120395
24EPHB21.27373507
25GRK61.20460843
26TYRO31.20069089
27PRKCQ1.15993743
28MAP3K41.14115531
29LIMK11.13957852
30NUAK11.13687799
31VRK21.13280652
32TESK21.11667014
33NME21.09787388
34LRRK21.07290532
35PRKCG1.05439752
36MAPK131.03224235
37STK111.01464382
38WNK31.00137484
39CAMKK10.96649671
40CAMK10.96157481
41INSRR0.94573957
42ADRBK10.93576956
43CSNK1G20.93415525
44TNK20.93361022
45STK390.92766475
46BTK0.92452586
47PIM20.90857589
48IKBKB0.90781452
49MINK10.88471520
50OXSR10.87992803
51VRK10.86635289
52RPS6KA50.85800085
53PAK30.83601737
54PHKG10.80303708
55PHKG20.80303708
56MAP3K110.79431491
57MAP2K20.79286535
58NEK20.78525070
59MARK30.77991142
60PIM10.77678414
61CSNK1G30.77347196
62CAMKK20.77096600
63OBSCN0.76898792
64PRKACA0.72365110
65TEC0.67746775
66KIT0.64945932
67CSNK2A20.63846983
68ABL20.63142382
69PDK20.59338846
70RPS6KA20.59257191
71ITK0.59252890
72GRK70.59059847
73MAPK150.58552352
74AURKA0.57510437
75CHUK0.56132509
76RPS6KA60.55662228
77DAPK30.54853350
78MYLK0.54624256
79EPHA40.54160798
80MARK10.53011781
81PKN10.52618597
82SYK0.52552414
83CSNK1G10.51891011
84DYRK1B0.51312525
85AURKB0.50799948
86CAMK1D0.50123331
87DYRK30.48466970
88CDC70.48225477
89MAP4K10.47639481
90CSNK1A1L0.47522174
91PRKCA0.46186455
92NTRK30.45425294
93PRKCI0.44996683
94NME10.44608139
95CAMK2A0.43742059
96CSNK2A10.43561173
97CDK140.43526761
98MOS0.43497575
99PRKCZ0.41775659
100PRKCH0.39314263

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.13106092
2Oxidative phosphorylation_Homo sapiens_hsa001904.69622392
3Parkinsons disease_Homo sapiens_hsa050123.89362136
4Cardiac muscle contraction_Homo sapiens_hsa042603.08790580
5Huntingtons disease_Homo sapiens_hsa050162.74040449
6Alzheimers disease_Homo sapiens_hsa050102.67572689
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.55913588
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35062409
9Phototransduction_Homo sapiens_hsa047442.20991970
10RNA polymerase_Homo sapiens_hsa030202.03803924
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99095111
12Linoleic acid metabolism_Homo sapiens_hsa005911.90343674
13Sulfur relay system_Homo sapiens_hsa041221.71757963
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68293875
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60382986
16Protein export_Homo sapiens_hsa030601.40682148
17Nicotine addiction_Homo sapiens_hsa050331.37220044
18Primary immunodeficiency_Homo sapiens_hsa053401.34071973
19Proteasome_Homo sapiens_hsa030501.29552059
20Caffeine metabolism_Homo sapiens_hsa002321.28442653
21Nitrogen metabolism_Homo sapiens_hsa009101.28028331
22Asthma_Homo sapiens_hsa053101.25820544
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23422700
24RNA degradation_Homo sapiens_hsa030181.22855754
25Butanoate metabolism_Homo sapiens_hsa006501.19076846
26Olfactory transduction_Homo sapiens_hsa047401.18163834
27Fanconi anemia pathway_Homo sapiens_hsa034601.12790184
28Fat digestion and absorption_Homo sapiens_hsa049751.11757824
29Morphine addiction_Homo sapiens_hsa050321.07313787
30Tryptophan metabolism_Homo sapiens_hsa003801.06122550
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.00486975
32Graft-versus-host disease_Homo sapiens_hsa053321.00387739
33Propanoate metabolism_Homo sapiens_hsa006400.94479526
34Peroxisome_Homo sapiens_hsa041460.92922579
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92786228
36Pyrimidine metabolism_Homo sapiens_hsa002400.91924937
37Ether lipid metabolism_Homo sapiens_hsa005650.91417319
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89980665
39Arachidonic acid metabolism_Homo sapiens_hsa005900.84639191
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84141742
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83961402
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80983501
43Homologous recombination_Homo sapiens_hsa034400.77877065
44Autoimmune thyroid disease_Homo sapiens_hsa053200.76517576
45One carbon pool by folate_Homo sapiens_hsa006700.74150909
46Allograft rejection_Homo sapiens_hsa053300.73956486
47GABAergic synapse_Homo sapiens_hsa047270.72622252
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.71543780
49Type I diabetes mellitus_Homo sapiens_hsa049400.70824818
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67940159
51Basal cell carcinoma_Homo sapiens_hsa052170.67340082
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66937787
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66341848
54Folate biosynthesis_Homo sapiens_hsa007900.65531137
55Metabolic pathways_Homo sapiens_hsa011000.65437204
56Chemical carcinogenesis_Homo sapiens_hsa052040.64764060
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64690647
58Retinol metabolism_Homo sapiens_hsa008300.63157433
59Purine metabolism_Homo sapiens_hsa002300.62391650
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61691848
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60033367
62Collecting duct acid secretion_Homo sapiens_hsa049660.59276155
63Hematopoietic cell lineage_Homo sapiens_hsa046400.59249928
64Nucleotide excision repair_Homo sapiens_hsa034200.58443179
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55938087
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52087020
67Systemic lupus erythematosus_Homo sapiens_hsa053220.50380494
68Circadian entrainment_Homo sapiens_hsa047130.50035975
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.49586276
70Insulin secretion_Homo sapiens_hsa049110.46121427
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46110332
72Ovarian steroidogenesis_Homo sapiens_hsa049130.44202015
73Hedgehog signaling pathway_Homo sapiens_hsa043400.43689092
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42905236
75Serotonergic synapse_Homo sapiens_hsa047260.41759225
76Taste transduction_Homo sapiens_hsa047420.41300574
77Antigen processing and presentation_Homo sapiens_hsa046120.41201349
78Glutamatergic synapse_Homo sapiens_hsa047240.39417615
79Basal transcription factors_Homo sapiens_hsa030220.39265193
80Glycerolipid metabolism_Homo sapiens_hsa005610.38183154
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38155183
82Alcoholism_Homo sapiens_hsa050340.36989161
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36682613
84Base excision repair_Homo sapiens_hsa034100.36496479
85Rheumatoid arthritis_Homo sapiens_hsa053230.36312378
86Steroid biosynthesis_Homo sapiens_hsa001000.33491989
87Salivary secretion_Homo sapiens_hsa049700.33223069
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32063154
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31785024
90Cholinergic synapse_Homo sapiens_hsa047250.30821339
91beta-Alanine metabolism_Homo sapiens_hsa004100.29938625
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.28362356
93Dorso-ventral axis formation_Homo sapiens_hsa043200.28210722
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.26430498
95Tyrosine metabolism_Homo sapiens_hsa003500.25833130
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25569604
97Synaptic vesicle cycle_Homo sapiens_hsa047210.25001449
98Oxytocin signaling pathway_Homo sapiens_hsa049210.24925566
99Spliceosome_Homo sapiens_hsa030400.23829386
100Dilated cardiomyopathy_Homo sapiens_hsa054140.23553063

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