RPL14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.32057234
2* viral transcription (GO:0019083)7.50299408
3* translational termination (GO:0006415)7.25723057
4ribosomal small subunit biogenesis (GO:0042274)6.76082379
5maturation of SSU-rRNA (GO:0030490)6.53080537
6* translational elongation (GO:0006414)6.35216141
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.26968101
8* cotranslational protein targeting to membrane (GO:0006613)6.13344001
9* protein targeting to ER (GO:0045047)6.11932816
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.82754271
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.77069513
12* protein localization to endoplasmic reticulum (GO:0070972)5.73687547
13* translational initiation (GO:0006413)5.66312598
14* cellular protein complex disassembly (GO:0043624)5.62486193
15* viral life cycle (GO:0019058)5.61189971
16* ribosomal large subunit biogenesis (GO:0042273)5.11008573
17* protein complex disassembly (GO:0043241)4.96243172
18* macromolecular complex disassembly (GO:0032984)4.67893913
19DNA deamination (GO:0045006)4.60339604
20formation of translation preinitiation complex (GO:0001731)4.52203162
21* ribonucleoprotein complex biogenesis (GO:0022613)4.46583539
22DNA strand elongation involved in DNA replication (GO:0006271)4.41671715
23* translation (GO:0006412)4.36646605
24telomere maintenance via semi-conservative replication (GO:0032201)4.33866478
25* nuclear-transcribed mRNA catabolic process (GO:0000956)4.33438684
26regulation of translational fidelity (GO:0006450)4.25856222
27DNA strand elongation (GO:0022616)4.20967860
28* mRNA catabolic process (GO:0006402)4.11737704
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07971789
30* protein targeting to membrane (GO:0006612)3.99282607
31DNA replication initiation (GO:0006270)3.93378625
32* RNA catabolic process (GO:0006401)3.92591478
33* rRNA processing (GO:0006364)3.82042100
34telomere maintenance via recombination (GO:0000722)3.81740535
35ATP synthesis coupled proton transport (GO:0015986)3.71074702
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71074702
37* rRNA metabolic process (GO:0016072)3.68959308
38DNA unwinding involved in DNA replication (GO:0006268)3.66185440
39DNA replication checkpoint (GO:0000076)3.62317234
40nuclear pore complex assembly (GO:0051292)3.59821849
41mitotic recombination (GO:0006312)3.55487771
42nucleobase biosynthetic process (GO:0046112)3.54846828
43telomere maintenance via telomere lengthening (GO:0010833)3.50005509
44* cellular component biogenesis (GO:0044085)3.44800780
45CENP-A containing nucleosome assembly (GO:0034080)3.43297874
46chromatin remodeling at centromere (GO:0031055)3.42771602
47ribosome biogenesis (GO:0042254)3.41889696
48* protein targeting (GO:0006605)3.40706993
49pseudouridine synthesis (GO:0001522)3.38696816
50* establishment of protein localization to organelle (GO:0072594)3.37867509
51mitotic chromosome condensation (GO:0007076)3.31729400
52spliceosomal snRNP assembly (GO:0000387)3.31549116
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.31310974
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28735603
55purine nucleobase biosynthetic process (GO:0009113)3.28107662
56proteasome assembly (GO:0043248)3.24326034
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22527328
58IMP biosynthetic process (GO:0006188)3.14420654
59nuclear pore organization (GO:0006999)3.09749407
60termination of RNA polymerase III transcription (GO:0006386)3.08799147
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.08799147
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06022924
63chaperone-mediated protein transport (GO:0072321)3.05644418
64DNA replication-independent nucleosome assembly (GO:0006336)3.05016711
65DNA replication-independent nucleosome organization (GO:0034724)3.05016711
66transcription-coupled nucleotide-excision repair (GO:0006283)3.04515341
67protein localization to kinetochore (GO:0034501)3.03126236
68kinetochore organization (GO:0051383)3.01858076
69heterochromatin organization (GO:0070828)3.01588906
70spliceosomal complex assembly (GO:0000245)2.99541196
71mitotic metaphase plate congression (GO:0007080)2.99383422
72nucleobase-containing small molecule interconversion (GO:0015949)2.94986627
73viral mRNA export from host cell nucleus (GO:0046784)2.94274421
74rRNA modification (GO:0000154)2.92187497
75ribonucleoprotein complex assembly (GO:0022618)2.91483611
76oxidative phosphorylation (GO:0006119)2.91470192
77ribosome assembly (GO:0042255)2.90839109
78establishment of integrated proviral latency (GO:0075713)2.88502624
79DNA topological change (GO:0006265)2.88485123
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87783345
81* protein localization to membrane (GO:0072657)2.87740244
82* gene expression (GO:0010467)2.87001696
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86672724
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86657460
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86313375
86folic acid-containing compound biosynthetic process (GO:0009396)2.86111195
87ncRNA 3-end processing (GO:0043628)2.84994760
88mitotic nuclear envelope disassembly (GO:0007077)2.83702574
89* ncRNA processing (GO:0034470)2.82058572
90IMP metabolic process (GO:0046040)2.81226397
91negative regulation of ligase activity (GO:0051352)2.81028850
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81028850
93kinetochore assembly (GO:0051382)2.80833788
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80538302
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.80315254
96regulation of mitochondrial translation (GO:0070129)2.79348420
97negative regulation of mRNA processing (GO:0050686)2.78605722
98proline biosynthetic process (GO:0006561)2.78200189
99DNA replication-dependent nucleosome assembly (GO:0006335)2.77065613
100DNA replication-dependent nucleosome organization (GO:0034723)2.77065613
101mitotic sister chromatid segregation (GO:0000070)2.75777850
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75145554
103ribonucleoprotein complex subunit organization (GO:0071826)2.74940696
104protein targeting to mitochondrion (GO:0006626)2.74746731
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73550681
106termination of RNA polymerase I transcription (GO:0006363)2.72263919
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71641761
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71641761
109metaphase plate congression (GO:0051310)2.70945192
110* establishment of protein localization to membrane (GO:0090150)2.70922968
111negative regulation of RNA splicing (GO:0033119)2.70094125
112signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69126187
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69126187
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69126187
115G1/S transition of mitotic cell cycle (GO:0000082)2.68156842
116cell cycle G1/S phase transition (GO:0044843)2.68156842
117mRNA splicing, via spliceosome (GO:0000398)2.67609029
118RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.67609029
119* ncRNA metabolic process (GO:0034660)2.67287459
120signal transduction involved in DNA damage checkpoint (GO:0072422)2.66481929
121signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66481929
122telomere organization (GO:0032200)2.65884010
123telomere maintenance (GO:0000723)2.65750468
124protein localization to chromosome, centromeric region (GO:0071459)2.65228355
125transcription elongation from RNA polymerase I promoter (GO:0006362)2.64673110
126histone exchange (GO:0043486)2.64406401
127RNA splicing, via transesterification reactions (GO:0000375)2.62815418
128pore complex assembly (GO:0046931)2.61661078
129negative regulation of mRNA metabolic process (GO:1903312)2.58455915
130tRNA aminoacylation for protein translation (GO:0006418)2.58074808
131* cellular component disassembly (GO:0022411)2.57106155
132amino acid activation (GO:0043038)2.56996329
133tRNA aminoacylation (GO:0043039)2.56996329
134sister chromatid segregation (GO:0000819)2.55146045
135* protein localization to organelle (GO:0033365)2.53679192
136termination of RNA polymerase II transcription (GO:0006369)2.51449595
137establishment of protein localization to mitochondrion (GO:0072655)2.49259519
138regulation of translational elongation (GO:0006448)2.48668699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.38806306
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.63651947
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00950681
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24602102
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24144205
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.23297728
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.17614008
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14465159
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09662193
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.02298072
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95610857
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90988579
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84943172
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.79641251
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75149245
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74222991
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72262716
18* XRN2_22483619_ChIP-Seq_HELA_Human2.54338533
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42664565
20VDR_23849224_ChIP-Seq_CD4+_Human2.38167545
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37764003
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28626096
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25065789
24DCP1A_22483619_ChIP-Seq_HELA_Human2.16719573
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10035588
26FOXP3_21729870_ChIP-Seq_TREG_Human2.09931116
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08398538
28* TTF2_22483619_ChIP-Seq_HELA_Human2.06253931
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02575506
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98886381
31ELK1_19687146_ChIP-ChIP_HELA_Human1.83652054
32* GABP_19822575_ChIP-Seq_HepG2_Human1.82182135
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81258061
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79623035
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79117768
36ZNF263_19887448_ChIP-Seq_K562_Human1.77113972
37* E2F1_21310950_ChIP-Seq_MCF-7_Human1.65270536
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65224699
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64552218
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62617305
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62258638
42AR_21909140_ChIP-Seq_LNCAP_Human1.61596388
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.58715867
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58396036
45CIITA_25753668_ChIP-Seq_RAJI_Human1.57438121
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56239755
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54001383
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.53161765
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51020447
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51019773
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50359812
52MYC_22102868_ChIP-Seq_BL_Human1.49116403
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48337752
54* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48240484
55* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43138450
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.42625723
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38495422
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38245895
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.26498088
60* KDM5A_27292631_Chip-Seq_BREAST_Human1.26431755
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21950216
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21842041
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21386882
64* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21214290
65VDR_21846776_ChIP-Seq_THP-1_Human1.21141327
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19974534
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19518382
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17967564
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.17343455
70SPI1_23547873_ChIP-Seq_NB4_Human1.15971279
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15724712
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12985239
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12599401
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09916421
75MYC_18940864_ChIP-ChIP_HL60_Human1.09298764
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08356340
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07137978
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06983811
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06820418
80TFEB_21752829_ChIP-Seq_HELA_Human1.05062003
81NCOR1_26117541_ChIP-Seq_K562_Human1.03314834
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03205223
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03147550
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02083545
85* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01624292
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01141923
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00956648
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00691674
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00138887
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99889953
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99389606
92CHD1_26751641_Chip-Seq_LNCaP_Human0.98132593
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97980665
94* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97872607
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97046348
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.96868110
97MAF_26560356_Chip-Seq_TH2_Human0.96641732
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95571291
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94817845
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94145745
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94077339
102MAF_26560356_Chip-Seq_TH1_Human0.93351929
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92254456
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88003019
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87057193
106FOXP1_21924763_ChIP-Seq_HESCs_Human0.86964415
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86653177
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85149217
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.84906235
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84373734
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84250698
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83867825
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79289716
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78577859
115* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78310462
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77341890
117* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76543299
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.75774731
119* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74487342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.89928427
2MP0004957_abnormal_blastocyst_morpholog4.13076556
3MP0010094_abnormal_chromosome_stability3.80864030
4MP0009379_abnormal_foot_pigmentation3.65071766
5MP0003111_abnormal_nucleus_morphology3.54644044
6MP0003077_abnormal_cell_cycle3.46197201
7MP0008057_abnormal_DNA_replication3.19208234
8MP0002396_abnormal_hematopoietic_system3.02523543
9MP0008058_abnormal_DNA_repair2.89060855
10MP0008007_abnormal_cellular_replicative2.60532780
11MP0003123_paternal_imprinting2.36564679
12MP0008932_abnormal_embryonic_tissue2.28711591
13MP0000490_abnormal_crypts_of2.16272806
14MP0003786_premature_aging2.00312228
15MP0003763_abnormal_thymus_physiology1.89066271
16MP0000350_abnormal_cell_proliferation1.79901507
17MP0004808_abnormal_hematopoietic_stem1.76552942
18MP0009333_abnormal_splenocyte_physiolog1.75549765
19MP0001730_embryonic_growth_arrest1.72047736
20MP0010352_gastrointestinal_tract_polyps1.68255855
21MP0005397_hematopoietic_system_phenotyp1.57925450
22MP0001545_abnormal_hematopoietic_system1.57925450
23MP0002132_abnormal_respiratory_system1.56217128
24MP0002877_abnormal_melanocyte_morpholog1.55908701
25MP0006054_spinal_hemorrhage1.53368487
26MP0004185_abnormal_adipocyte_glucose1.49537881
27MP0000678_abnormal_parathyroid_gland1.48692541
28MP0002019_abnormal_tumor_incidence1.41797814
29MP0002796_impaired_skin_barrier1.41548908
30MP0002398_abnormal_bone_marrow1.40404361
31MP0003567_abnormal_fetal_cardiomyocyte1.38688821
32MP0001835_abnormal_antigen_presentation1.38682335
33MP0000313_abnormal_cell_death1.37560345
34MP0005174_abnormal_tail_pigmentation1.33406981
35MP0001697_abnormal_embryo_size1.28705184
36MP0002722_abnormal_immune_system1.27983508
37MP0000703_abnormal_thymus_morphology1.26871937
38MP0002080_prenatal_lethality1.24536612
39MP0003186_abnormal_redox_activity1.23687989
40MP0008877_abnormal_DNA_methylation1.22403468
41MP0003315_abnormal_perineum_morphology1.21343687
42MP0005075_abnormal_melanosome_morpholog1.20584404
43MP0000689_abnormal_spleen_morphology1.20231135
44MP0001672_abnormal_embryogenesis/_devel1.17180866
45MP0005380_embryogenesis_phenotype1.17180866
46MP0005408_hypopigmentation1.14942250
47MP0009672_abnormal_birth_weight1.14113795
48MP0002429_abnormal_blood_cell1.13781910
49MP0001348_abnormal_lacrimal_gland1.11796255
50MP0002095_abnormal_skin_pigmentation1.11619025
51MP0005671_abnormal_response_to1.10762789
52MP0003718_maternal_effect1.10744202
53MP0002166_altered_tumor_susceptibility1.08435709
54MP0001881_abnormal_mammary_gland1.08007576
55MP0006035_abnormal_mitochondrial_morpho1.07762884
56MP0010307_abnormal_tumor_latency1.06834039
57MP0000685_abnormal_immune_system1.06720102
58MP0003984_embryonic_growth_retardation1.06607767
59MP0000858_altered_metastatic_potential1.06439276
60MP0001853_heart_inflammation1.06419342
61MP0001800_abnormal_humoral_immune1.05992425
62MP0000716_abnormal_immune_system1.03922297
63MP0002088_abnormal_embryonic_growth/wei1.03795954
64MP0002006_tumorigenesis1.03594499
65MP0009697_abnormal_copulation1.03247194
66MP0003941_abnormal_skin_development1.02735539
67MP0002086_abnormal_extraembryonic_tissu1.02578431
68MP0002085_abnormal_embryonic_tissue1.01387958
69MP0005451_abnormal_body_composition1.01334351
70MP0000465_gastrointestinal_hemorrhage1.01300647
71MP0002420_abnormal_adaptive_immunity1.00783929
72MP0010155_abnormal_intestine_physiology1.00312284
73MP0001819_abnormal_immune_cell0.98792839
74MP0003806_abnormal_nucleotide_metabolis0.98778880
75MP0003121_genomic_imprinting0.96734343
76MP0002938_white_spotting0.96150630
77MP0002452_abnormal_antigen_presenting0.94289893
78MP0010030_abnormal_orbit_morphology0.94058929
79MP0002160_abnormal_reproductive_system0.93661411
80MP0009785_altered_susceptibility_to0.93314836
81MP0003705_abnormal_hypodermis_morpholog0.92663939
82MP0004197_abnormal_fetal_growth/weight/0.91905151
83MP0001293_anophthalmia0.91391029
84MP0002405_respiratory_system_inflammati0.89997819
85MP0003866_abnormal_defecation0.89308381
86MP0002084_abnormal_developmental_patter0.89192757
87MP0001727_abnormal_embryo_implantation0.88770352
88MP0002148_abnormal_hypersensitivity_rea0.87899602
89MP0004233_abnormal_muscle_weight0.86657724
90MP0005025_abnormal_response_to0.86329988
91MP0005501_abnormal_skin_physiology0.86103091
92MP0002723_abnormal_immune_serum0.86061489
93MP0001873_stomach_inflammation0.84867927
94MP0002210_abnormal_sex_determination0.81808568
95MP0000477_abnormal_intestine_morphology0.81714120
96MP0006036_abnormal_mitochondrial_physio0.80426152
97MP0000358_abnormal_cell_content/0.77805572
98MP0005076_abnormal_cell_differentiation0.77668452
99MP0004147_increased_porphyrin_level0.77319415
100MP0003436_decreased_susceptibility_to0.76969903
101MP0005000_abnormal_immune_tolerance0.76906755
102MP0001661_extended_life_span0.76822380
103MP0010234_abnormal_vibrissa_follicle0.74611973
104MP0006292_abnormal_olfactory_placode0.74139758
105MP0005023_abnormal_wound_healing0.73747259
106MP0001145_abnormal_male_reproductive0.72595215
107MP0000537_abnormal_urethra_morphology0.71683974
108MP0004381_abnormal_hair_follicle0.67568243
109MP0001346_abnormal_lacrimal_gland0.67458150
110MP0002163_abnormal_gland_morphology0.66530085
111MP0005666_abnormal_adipose_tissue0.66084729
112MP0004264_abnormal_extraembryonic_tissu0.62287972
113MP0008995_early_reproductive_senescence0.61800560
114MP0002111_abnormal_tail_morphology0.60844650
115MP0001286_abnormal_eye_development0.60090146
116MP0009278_abnormal_bone_marrow0.60034280
117MP0009931_abnormal_skin_appearance0.59883198
118MP0000653_abnormal_sex_gland0.59670460
119MP0002697_abnormal_eye_size0.59278851
120MP0000627_abnormal_mammary_gland0.58401797
121MP0000372_irregular_coat_pigmentation0.57972619
122MP0001119_abnormal_female_reproductive0.57812878
123MP0009053_abnormal_anal_canal0.56747893
124MP0001929_abnormal_gametogenesis0.56447865
125MP0000428_abnormal_craniofacial_morphol0.55100992
126MP0002009_preneoplasia0.53819732
127MP0005384_cellular_phenotype0.53567036
128MP0004133_heterotaxia0.52248546

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.74427459
2Abnormal number of erythroid precursors (HP:0012131)7.18246212
3Reticulocytopenia (HP:0001896)7.06728469
4Macrocytic anemia (HP:0001972)5.09571552
5Pallor (HP:0000980)4.83599730
6Aplastic anemia (HP:0001915)4.22949680
7Colon cancer (HP:0003003)3.87692524
8Thrombocytosis (HP:0001894)3.82230729
9Birth length less than 3rd percentile (HP:0003561)3.71865605
10Oral leukoplakia (HP:0002745)3.63441327
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.60527786
1211 pairs of ribs (HP:0000878)3.45885145
13Progressive muscle weakness (HP:0003323)3.09477153
14Absent thumb (HP:0009777)2.99741497
15Breast hypoplasia (HP:0003187)2.93716805
16Rough bone trabeculation (HP:0100670)2.85001708
17Increased hepatocellular lipid droplets (HP:0006565)2.71150523
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68610525
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68610525
20Trismus (HP:0000211)2.63274626
21Selective tooth agenesis (HP:0001592)2.60750958
22Chromsome breakage (HP:0040012)2.59568971
23Myelodysplasia (HP:0002863)2.56202509
24Abnormality of the preputium (HP:0100587)2.55729075
25Abnormality of reticulocytes (HP:0004312)2.47018099
26Type I transferrin isoform profile (HP:0003642)2.45771802
27Progressive external ophthalmoplegia (HP:0000590)2.45145106
28Multiple enchondromatosis (HP:0005701)2.43867576
29Abnormal hemoglobin (HP:0011902)2.42046556
30Acute encephalopathy (HP:0006846)2.41923843
31Exertional dyspnea (HP:0002875)2.40917259
32Hepatocellular necrosis (HP:0001404)2.40405238
33Testicular atrophy (HP:0000029)2.38340124
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37981087
35IgM deficiency (HP:0002850)2.37932809
36Seborrheic dermatitis (HP:0001051)2.35514916
37Premature graying of hair (HP:0002216)2.35053708
38Microretrognathia (HP:0000308)2.34336703
39Carpal bone hypoplasia (HP:0001498)2.33722928
40Mitochondrial inheritance (HP:0001427)2.32341070
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.32085852
42Patellar aplasia (HP:0006443)2.32029919
43Lipid accumulation in hepatocytes (HP:0006561)2.31906955
44Abnormality of glycolysis (HP:0004366)2.30955001
45Abnormality of the anterior horn cell (HP:0006802)2.30775095
46Degeneration of anterior horn cells (HP:0002398)2.30775095
47Triphalangeal thumb (HP:0001199)2.28625909
48Meckel diverticulum (HP:0002245)2.28612385
49Pancytopenia (HP:0001876)2.24130862
50Aplasia/Hypoplasia of the patella (HP:0006498)2.22483985
51Asplenia (HP:0001746)2.22342643
52Abnormality of chromosome stability (HP:0003220)2.22162012
53Hypertensive crisis (HP:0100735)2.22003921
54Depressed nasal ridge (HP:0000457)2.20609650
55Increased serum pyruvate (HP:0003542)2.19719612
56Increased CSF lactate (HP:0002490)2.19524262
57Hyperthyroidism (HP:0000836)2.18399849
58Abnormality of the ileum (HP:0001549)2.16954819
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16862424
60Hypoplasia of the radius (HP:0002984)2.16430312
61Neoplasm of the pancreas (HP:0002894)2.16185701
62Short middle phalanx of the 5th finger (HP:0004220)2.15825468
63Increased serum lactate (HP:0002151)2.15625013
64Stenosis of the external auditory canal (HP:0000402)2.12258945
65Respiratory difficulties (HP:0002880)2.11547457
66Petechiae (HP:0000967)2.11275396
67Hepatic necrosis (HP:0002605)2.09489470
68Homocystinuria (HP:0002156)2.08724727
69Abnormality of homocysteine metabolism (HP:0010919)2.08724727
70Medulloblastoma (HP:0002885)2.08159650
71Autoimmune hemolytic anemia (HP:0001890)2.07565490
72Aplasia/Hypoplasia of the thymus (HP:0010515)2.07384319
73Missing ribs (HP:0000921)2.06914099
74Bone marrow hypocellularity (HP:0005528)2.06607266
75Cleft eyelid (HP:0000625)2.05766175
76Cerebral hypomyelination (HP:0006808)2.05234343
77Abnormal trabecular bone morphology (HP:0100671)2.04600609
78Glossoptosis (HP:0000162)2.01655738
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.01489136
80Increased muscle lipid content (HP:0009058)2.00792197
81Lymphoma (HP:0002665)2.00467609
82Gout (HP:0001997)2.00112120
83Truncus arteriosus (HP:0001660)1.99920930
84Atresia of the external auditory canal (HP:0000413)1.99724091
85Cerebral edema (HP:0002181)1.96801374
86Abnormal number of incisors (HP:0011064)1.96262790
87Agnosia (HP:0010524)1.96206234
88Basal cell carcinoma (HP:0002671)1.95956099
89Cellular immunodeficiency (HP:0005374)1.95870635
90Sparse eyelashes (HP:0000653)1.95100455
91Poikiloderma (HP:0001029)1.93989113
92Acute necrotizing encephalopathy (HP:0006965)1.93459950
93Congenital, generalized hypertrichosis (HP:0004540)1.93283017
94Horseshoe kidney (HP:0000085)1.93207170
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93107243
96Progressive macrocephaly (HP:0004481)1.91222612
97Abnormality of T cell physiology (HP:0011840)1.90966561
98Hypoparathyroidism (HP:0000829)1.90289449
99Exercise intolerance (HP:0003546)1.90106516
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.89748327
101Microvesicular hepatic steatosis (HP:0001414)1.89600161
102Small intestinal stenosis (HP:0012848)1.89491814
103Duodenal stenosis (HP:0100867)1.89491814
104Abnormality of cochlea (HP:0000375)1.88802367
105Amaurosis fugax (HP:0100576)1.87579220
106Tracheoesophageal fistula (HP:0002575)1.86911622
107Agammaglobulinemia (HP:0004432)1.84349811
108Lactic acidosis (HP:0003128)1.81324004
109Villous atrophy (HP:0011473)1.80947596
110Abnormality of small intestinal villus morphology (HP:0011472)1.80947596
111Thick lower lip vermilion (HP:0000179)1.80928254
112Abnormal lung lobation (HP:0002101)1.79434634
113Increased intramyocellular lipid droplets (HP:0012240)1.79332607
114Abnormal mitochondria in muscle tissue (HP:0008316)1.77895614
115Neoplasm of the colon (HP:0100273)1.77684149
116Reticulocytosis (HP:0001923)1.75802392
1173-Methylglutaconic aciduria (HP:0003535)1.74679306
118Elevated erythrocyte sedimentation rate (HP:0003565)1.73193906
119Squamous cell carcinoma (HP:0002860)1.72695449
120Muscle fiber atrophy (HP:0100295)1.72092002
121Increased nuchal translucency (HP:0010880)1.71327862
122Migraine (HP:0002076)1.71076838
123Secondary amenorrhea (HP:0000869)1.70678115
124Abnormality of methionine metabolism (HP:0010901)1.69500986
125Rhabdomyosarcoma (HP:0002859)1.68262408
126Pulmonary fibrosis (HP:0002206)1.66708595
127Renal Fanconi syndrome (HP:0001994)1.66003425
128Neoplasm of head and neck (HP:0012288)1.65469803
129Esophageal neoplasm (HP:0100751)1.65469803
130Premature ovarian failure (HP:0008209)1.65280695
131Acute lymphatic leukemia (HP:0006721)1.64982150
132Absent radius (HP:0003974)1.64831376
133Premature skin wrinkling (HP:0100678)1.64800167
134Abnormal glycosylation (HP:0012345)1.64487452
135Abnormality of the fingertips (HP:0001211)1.62748664
136Deep palmar crease (HP:0006191)1.62337352
137Gastrointestinal stroma tumor (HP:0100723)1.61501776
138Acute myeloid leukemia (HP:0004808)1.60981558
139Panhypogammaglobulinemia (HP:0003139)1.60135343
140Megaloblastic anemia (HP:0001889)1.59284852
141Ragged-red muscle fibers (HP:0003200)1.58623545
142Sparse lateral eyebrow (HP:0005338)1.57699523
143Abnormality of DNA repair (HP:0003254)1.56930845
144Nasolacrimal duct obstruction (HP:0000579)1.55673449
145Abnormality of subcutaneous fat tissue (HP:0001001)1.54995789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.28319625
2BUB13.78299102
3WEE13.76503466
4EIF2AK12.99060840
5TLK12.97058451
6SMG12.89931175
7CDC72.88422019
8VRK22.88089148
9STK162.59445565
10SRPK12.34201098
11VRK12.20253210
12RPS6KB22.14300887
13NEK21.96678777
14BRSK21.93515749
15PASK1.91720399
16PIM21.86155061
17EIF2AK31.83935550
18TSSK61.83440646
19ACVR1B1.81288569
20PRPF4B1.79327782
21TGFBR11.74699254
22TRIB31.73047999
23MKNK11.70482837
24DYRK31.68847696
25ICK1.68545513
26AURKB1.56848429
27MAP4K11.53419725
28RPS6KA41.52088892
29PLK11.51065373
30MST41.50486089
31CDK71.50156488
32LRRK21.45096236
33TTK1.43779595
34EEF2K1.41628646
35CDK121.38845794
36ATR1.34457029
37TESK21.30786505
38PLK41.28416792
39TEC1.28254881
40SCYL21.25379175
41FLT31.23050892
42MKNK21.21780299
43NEK11.14251285
44TAF11.13081027
45CDK41.12734776
46ILK1.11454893
47PDK21.10910142
48MAP3K81.04337752
49NME11.01576670
50AURKA1.01010801
51PIM10.99734083
52IRAK30.99703894
53STK100.99421771
54BTK0.99366737
55MAP3K100.98700837
56KDR0.98239781
57MAP2K30.97340034
58ZAK0.93932899
59CDK190.92792834
60CDK80.91787793
61BRSK10.91291639
62CHEK20.89703539
63PLK30.88506391
64MAP3K130.88341521
65PAK40.88234453
66ALK0.88142781
67STK40.88125166
68ZAP700.85511593
69KIT0.79754357
70CSNK2A20.79452973
71ARAF0.77266463
72CHEK10.76703086
73PKN20.75748323
74NUAK10.75634328
75MAP3K110.74680852
76EPHA20.74138494
77CSNK2A10.73498522
78MAPKAPK30.68447019
79BLK0.68238267
80PBK0.67975258
81EIF2AK20.67269374
82CCNB10.65533066
83RPS6KA50.63651402
84MAP3K30.63630166
85IKBKB0.62683898
86PTK60.62403919
87RIPK40.61779573
88PAK10.61243887
89ATM0.58037575
90BCKDK0.57510851
91SIK10.57502165
92CDK20.54902561
93NLK0.54663065
94TXK0.54112745
95JAK30.53996470
96CLK10.53550538
97MTOR0.52490687
98IRAK40.49302514
99TESK10.48291359
100PRKCI0.47589304
101MAP2K20.46862352
102TAOK20.46623379
103CSNK1E0.46180721
104ERN10.45938683
105AKT20.44829486
106TYK20.44012681
107BMPR20.42965034
108KSR20.42128480
109BRAF0.41807059
110MAP2K60.40931146
111NEK90.40187274
112CSF1R0.39850528
113FGFR40.39623148
114RAF10.38854052
115RPS6KA60.37953718
116RPS6KL10.37529671
117RPS6KC10.37529671
118CDK60.36722775
119LYN0.36348394
120SYK0.36248296
121MARK30.36200533
122RPS6KB10.34372968
123DAPK30.33530474
124STK30.33470830
125PAK20.30580471
126MYLK0.30188228
127CDK10.29974338

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.14367469
2DNA replication_Homo sapiens_hsa030304.60995825
3Mismatch repair_Homo sapiens_hsa034303.89366438
4Proteasome_Homo sapiens_hsa030503.40772672
5RNA polymerase_Homo sapiens_hsa030203.32510736
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10098637
7Spliceosome_Homo sapiens_hsa030403.08697998
8Homologous recombination_Homo sapiens_hsa034402.90281270
9Base excision repair_Homo sapiens_hsa034102.76353024
10Nucleotide excision repair_Homo sapiens_hsa034202.68002987
11RNA transport_Homo sapiens_hsa030132.52154532
12Pyrimidine metabolism_Homo sapiens_hsa002402.51799203
13One carbon pool by folate_Homo sapiens_hsa006702.13536579
14Cell cycle_Homo sapiens_hsa041102.00739721
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94430469
16Non-homologous end-joining_Homo sapiens_hsa034501.85459258
17Fanconi anemia pathway_Homo sapiens_hsa034601.82627664
18RNA degradation_Homo sapiens_hsa030181.70258804
19Basal transcription factors_Homo sapiens_hsa030221.66677902
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63508783
21Protein export_Homo sapiens_hsa030601.62645614
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60191739
23Parkinsons disease_Homo sapiens_hsa050121.39791857
24Purine metabolism_Homo sapiens_hsa002301.29948708
25p53 signaling pathway_Homo sapiens_hsa041151.28830871
26Oxidative phosphorylation_Homo sapiens_hsa001901.24391975
27mRNA surveillance pathway_Homo sapiens_hsa030151.21452028
28Huntingtons disease_Homo sapiens_hsa050161.17661319
29Systemic lupus erythematosus_Homo sapiens_hsa053221.07492702
30Epstein-Barr virus infection_Homo sapiens_hsa051691.07317390
31Antigen processing and presentation_Homo sapiens_hsa046121.05004766
32Pyruvate metabolism_Homo sapiens_hsa006200.99781582
33Herpes simplex infection_Homo sapiens_hsa051680.99278208
34Primary immunodeficiency_Homo sapiens_hsa053400.95230687
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91559320
36Sulfur relay system_Homo sapiens_hsa041220.90372073
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87877989
38Folate biosynthesis_Homo sapiens_hsa007900.87088395
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84718470
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77070787
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.75850573
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74844665
43Pentose phosphate pathway_Homo sapiens_hsa000300.74714014
44Viral carcinogenesis_Homo sapiens_hsa052030.68805048
45Alzheimers disease_Homo sapiens_hsa050100.66984654
46Legionellosis_Homo sapiens_hsa051340.65147330
47Thyroid cancer_Homo sapiens_hsa052160.63153651
48HTLV-I infection_Homo sapiens_hsa051660.60602677
49N-Glycan biosynthesis_Homo sapiens_hsa005100.59178943
50Vitamin B6 metabolism_Homo sapiens_hsa007500.58983970
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.56804312
52Hematopoietic cell lineage_Homo sapiens_hsa046400.56797439
53Glutathione metabolism_Homo sapiens_hsa004800.56447436
54Non-small cell lung cancer_Homo sapiens_hsa052230.56324636
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54985947
56Measles_Homo sapiens_hsa051620.54809231
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52719904
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.52307492
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52153851
60Pancreatic cancer_Homo sapiens_hsa052120.50993455
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49543582
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49059046
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.48604494
64Cardiac muscle contraction_Homo sapiens_hsa042600.48460633
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.47480010
66Apoptosis_Homo sapiens_hsa042100.43858279
67Small cell lung cancer_Homo sapiens_hsa052220.43055736
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42810743
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.42620944
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40239430
71Allograft rejection_Homo sapiens_hsa053300.39244222
72Arachidonic acid metabolism_Homo sapiens_hsa005900.37877322
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37414215
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37315036
75Selenocompound metabolism_Homo sapiens_hsa004500.36286546
76Oocyte meiosis_Homo sapiens_hsa041140.35879691
77Asthma_Homo sapiens_hsa053100.35787243
78Biosynthesis of amino acids_Homo sapiens_hsa012300.33853139
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32996322
80Galactose metabolism_Homo sapiens_hsa000520.32851824
81Leishmaniasis_Homo sapiens_hsa051400.32466709
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32154656
83Alcoholism_Homo sapiens_hsa050340.31155578
84Hepatitis B_Homo sapiens_hsa051610.30661036
85Shigellosis_Homo sapiens_hsa051310.30646886
86Acute myeloid leukemia_Homo sapiens_hsa052210.28924708
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28494469
88Metabolic pathways_Homo sapiens_hsa011000.28407025
89Influenza A_Homo sapiens_hsa051640.27851380
90mTOR signaling pathway_Homo sapiens_hsa041500.27478997
91Renal cell carcinoma_Homo sapiens_hsa052110.26947318
92Prostate cancer_Homo sapiens_hsa052150.26337378
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25760142
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25160252
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23844849
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.23802455
97MicroRNAs in cancer_Homo sapiens_hsa052060.23286051
98T cell receptor signaling pathway_Homo sapiens_hsa046600.22802695
99Carbon metabolism_Homo sapiens_hsa012000.22290251
100Lysine degradation_Homo sapiens_hsa003100.20816066
101Basal cell carcinoma_Homo sapiens_hsa052170.20526033
102Graft-versus-host disease_Homo sapiens_hsa053320.20425373
103TGF-beta signaling pathway_Homo sapiens_hsa043500.20193963
104Bladder cancer_Homo sapiens_hsa052190.19953268
105VEGF signaling pathway_Homo sapiens_hsa043700.19581109
106Other glycan degradation_Homo sapiens_hsa005110.19149136
107Notch signaling pathway_Homo sapiens_hsa043300.18887082
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17746171
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17371768
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17050719
111HIF-1 signaling pathway_Homo sapiens_hsa040660.16785656
112Pathways in cancer_Homo sapiens_hsa052000.16496919
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16374330
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15566755
115Endometrial cancer_Homo sapiens_hsa052130.15534134
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14830584
117Renin-angiotensin system_Homo sapiens_hsa046140.14743164
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14002361
119Autoimmune thyroid disease_Homo sapiens_hsa053200.13877138
120Fructose and mannose metabolism_Homo sapiens_hsa000510.13846683
121Chronic myeloid leukemia_Homo sapiens_hsa052200.13787387
122Colorectal cancer_Homo sapiens_hsa052100.13214889
123Fatty acid elongation_Homo sapiens_hsa000620.12263561
124B cell receptor signaling pathway_Homo sapiens_hsa046620.12255705
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12248151
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11004387
127Vitamin digestion and absorption_Homo sapiens_hsa049770.09885676

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