RPL14P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translational termination (GO:0006415)9.88133150
2ribosomal small subunit assembly (GO:0000028)8.80042860
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.50107033
4cotranslational protein targeting to membrane (GO:0006613)8.41975659
5protein targeting to ER (GO:0045047)8.30565931
6translational elongation (GO:0006414)8.24538013
7establishment of protein localization to endoplasmic reticulum (GO:0072599)7.94993913
8ribosomal small subunit biogenesis (GO:0042274)7.94010039
9maturation of SSU-rRNA (GO:0030490)7.70257586
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.70122354
11protein localization to endoplasmic reticulum (GO:0070972)7.68636655
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.65533843
13cellular protein complex disassembly (GO:0043624)7.65384214
14viral life cycle (GO:0019058)7.42255239
15energy coupled proton transport, down electrochemical gradient (GO:0015985)7.21373152
16ATP synthesis coupled proton transport (GO:0015986)7.21373152
17translational initiation (GO:0006413)6.77630595
18protein complex disassembly (GO:0043241)6.57059914
19establishment of protein localization to mitochondrial membrane (GO:0090151)6.51176597
20ribosomal large subunit biogenesis (GO:0042273)6.32020435
21macromolecular complex disassembly (GO:0032984)6.18863377
22protein targeting to membrane (GO:0006612)5.51962499
23chaperone-mediated protein transport (GO:0072321)5.31003159
24nuclear-transcribed mRNA catabolic process (GO:0000956)5.29557669
25inner mitochondrial membrane organization (GO:0007007)5.00539482
26mRNA catabolic process (GO:0006402)4.99922545
27translation (GO:0006412)4.91925980
28respiratory electron transport chain (GO:0022904)4.68834266
29electron transport chain (GO:0022900)4.59596930
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58283574
31RNA catabolic process (GO:0006401)4.55216231
32ribonucleoprotein complex biogenesis (GO:0022613)4.05834258
33ATP biosynthetic process (GO:0006754)3.96466136
34establishment of protein localization to membrane (GO:0090150)3.67895915
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.60253663
36purine nucleoside triphosphate biosynthetic process (GO:0009145)3.58681422
37otic vesicle formation (GO:0030916)3.51835802
38cellular component biogenesis (GO:0044085)3.47883276
39spliceosomal snRNP assembly (GO:0000387)3.46564238
40behavioral response to nicotine (GO:0035095)3.45436151
41formation of translation preinitiation complex (GO:0001731)3.42443180
42protein targeting (GO:0006605)3.40816266
43establishment of protein localization to organelle (GO:0072594)3.34637330
44protein neddylation (GO:0045116)3.30410895
45hydrogen ion transmembrane transport (GO:1902600)3.29648168
46rRNA processing (GO:0006364)3.15792614
47ribonucleoside triphosphate biosynthetic process (GO:0009201)3.15513860
48intracellular protein transmembrane import (GO:0044743)3.12061381
49rRNA metabolic process (GO:0016072)3.05961255
50NADH dehydrogenase complex assembly (GO:0010257)3.01163015
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01163015
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.01163015
53lateral sprouting from an epithelium (GO:0060601)2.97330805
54DNA damage response, detection of DNA damage (GO:0042769)2.95751253
55proton transport (GO:0015992)2.91894506
56protein-cofactor linkage (GO:0018065)2.87146141
57protein localization to membrane (GO:0072657)2.86449579
58hydrogen transport (GO:0006818)2.85127820
59spliceosomal complex assembly (GO:0000245)2.84991725
60nucleoside triphosphate biosynthetic process (GO:0009142)2.82613970
61protein complex biogenesis (GO:0070271)2.82540310
62rRNA modification (GO:0000154)2.81485103
63purine nucleoside monophosphate biosynthetic process (GO:0009127)2.81280523
64purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.81280523
65cullin deneddylation (GO:0010388)2.76117693
66sequestering of actin monomers (GO:0042989)2.75935289
67midbrain development (GO:0030901)2.75389140
68neuron fate determination (GO:0048664)2.71904481
69protein deneddylation (GO:0000338)2.67519327
70mitochondrial respiratory chain complex assembly (GO:0033108)2.66548684
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65082471
72CENP-A containing nucleosome assembly (GO:0034080)2.64650310
73epithelial cilium movement (GO:0003351)2.62880959
74somite development (GO:0061053)2.61831997
75chromatin remodeling at centromere (GO:0031055)2.59019432
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56515997
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51312947
78protein localization to organelle (GO:0033365)2.45796172
79GTP biosynthetic process (GO:0006183)2.45580830
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45096132
81establishment of protein localization to mitochondrion (GO:0072655)2.39785254
82proteasome assembly (GO:0043248)2.38145942
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.35257803
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.35257803
85mitochondrial transport (GO:0006839)2.34222566
86rRNA methylation (GO:0031167)2.33244570
87ribonucleoprotein complex assembly (GO:0022618)2.32834793
88protein localization to mitochondrion (GO:0070585)2.32008733
89oxidative phosphorylation (GO:0006119)2.31830514
90protein targeting to mitochondrion (GO:0006626)2.31222231
91intracellular protein transmembrane transport (GO:0065002)2.31054095
92protein transmembrane transport (GO:0071806)2.30409819
93organelle disassembly (GO:1903008)2.29657412
94regulation of mitochondrial translation (GO:0070129)2.29419662
95ribonucleoside monophosphate biosynthetic process (GO:0009156)2.29288803
96cellular component disassembly (GO:0022411)2.26611483
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.26016098
98termination of RNA polymerase III transcription (GO:0006386)2.26016098
99nucleoside monophosphate biosynthetic process (GO:0009124)2.20860784
100viral transcription (GO:0019083)10.3206488

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.08088524
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.19483126
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.78329352
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.74222856
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70575128
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.50808770
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46280127
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07828387
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84235925
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83862693
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61505423
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.59276497
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54291470
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46194148
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.35842304
16VDR_22108803_ChIP-Seq_LS180_Human2.34174000
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32724009
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31712025
19ELK1_19687146_ChIP-ChIP_HELA_Human2.28580076
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27357518
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22547273
22TTF2_22483619_ChIP-Seq_HELA_Human2.09059909
23VDR_23849224_ChIP-Seq_CD4+_Human2.04877065
24EZH2_22144423_ChIP-Seq_EOC_Human2.03165664
25XRN2_22483619_ChIP-Seq_HELA_Human1.99864571
26EWS_26573619_Chip-Seq_HEK293_Human1.99235642
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.94341972
28IGF1R_20145208_ChIP-Seq_DFB_Human1.91643743
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90770592
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85864419
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85688416
32MYC_18940864_ChIP-ChIP_HL60_Human1.80137764
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79369711
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.73767545
35ZNF274_21170338_ChIP-Seq_K562_Hela1.70723617
36FOXP3_21729870_ChIP-Seq_TREG_Human1.69157502
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68196361
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.62955707
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58256856
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56387651
41FUS_26573619_Chip-Seq_HEK293_Human1.56262170
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54238625
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49114219
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44700922
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44464577
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.44331999
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.42277761
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.42009005
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36111200
50TP53_22573176_ChIP-Seq_HFKS_Human1.34022457
51RNF2_27304074_Chip-Seq_NSC_Mouse1.29191181
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28995977
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25162080
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23564701
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22718236
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.22476346
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22330070
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20738970
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.19158874
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18225501
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17631095
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.11239075
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11089767
64P300_19829295_ChIP-Seq_ESCs_Human1.07021259
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05517923
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.04977445
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04932966
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03462145
69GBX2_23144817_ChIP-Seq_PC3_Human1.01898978
70E2F7_22180533_ChIP-Seq_HELA_Human1.01242957
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00233678
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98359135
73JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98250618
74NANOG_16153702_ChIP-ChIP_HESCs_Human0.97963488
75DCP1A_22483619_ChIP-Seq_HELA_Human0.97813727
76TAF15_26573619_Chip-Seq_HEK293_Human0.97498298
77HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97386648
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96350784
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.96350784
80PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93949165
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.93167906
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92767504
83TP53_20018659_ChIP-ChIP_R1E_Mouse0.92744176
84NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91043291
85ERG_20517297_ChIP-Seq_VCAP_Human0.91041315
86AR_20517297_ChIP-Seq_VCAP_Human0.89765504
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89175502
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83992426
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82503518
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77792458
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.76499179
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76437222
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76437222
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76437222
95GABP_19822575_ChIP-Seq_HepG2_Human0.76368598
96NCOR_22424771_ChIP-Seq_293T_Human0.76242251
97IRF1_19129219_ChIP-ChIP_H3396_Human0.75817991
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75417721
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.75357018
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74659642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.25983970
2MP0006292_abnormal_olfactory_placode3.13180475
3MP0003136_yellow_coat_color3.07119961
4MP0000566_synostosis2.82680288
5MP0000372_irregular_coat_pigmentation2.77836947
6MP0006072_abnormal_retinal_apoptosis2.65574517
7MP0008995_early_reproductive_senescence2.54557220
8MP0010030_abnormal_orbit_morphology2.53797449
9MP0003878_abnormal_ear_physiology2.53369756
10MP0005377_hearing/vestibular/ear_phenot2.53369756
11MP0002938_white_spotting2.38508940
12MP0004885_abnormal_endolymph2.36580385
13MP0000537_abnormal_urethra_morphology2.14323090
14MP0003011_delayed_dark_adaptation2.10645640
15MP0000569_abnormal_digit_pigmentation1.84884218
16MP0002277_abnormal_respiratory_mucosa1.83790439
17MP0000049_abnormal_middle_ear1.83773439
18MP0004742_abnormal_vestibular_system1.78414904
19MP0005084_abnormal_gallbladder_morpholo1.76679158
20MP0001293_anophthalmia1.76463641
21MP0002234_abnormal_pharynx_morphology1.72195197
22MP0002837_dystrophic_cardiac_calcinosis1.71415816
23MP0001485_abnormal_pinna_reflex1.61609284
24MP0002653_abnormal_ependyma_morphology1.57037944
25MP0003315_abnormal_perineum_morphology1.50111691
26MP0003938_abnormal_ear_development1.44507857
27MP0003693_abnormal_embryo_hatching1.44002399
28MP0003567_abnormal_fetal_cardiomyocyte1.42580100
29MP0005174_abnormal_tail_pigmentation1.34287143
30MP0002282_abnormal_trachea_morphology1.33575203
31MP0002638_abnormal_pupillary_reflex1.32868086
32MP0003937_abnormal_limbs/digits/tail_de1.32803446
33MP0002102_abnormal_ear_morphology1.32328330
34MP0005253_abnormal_eye_physiology1.31829498
35MP0002160_abnormal_reproductive_system1.31536230
36MP0001188_hyperpigmentation1.30421264
37MP0008877_abnormal_DNA_methylation1.28871424
38MP0003283_abnormal_digestive_organ1.27810475
39MP0005551_abnormal_eye_electrophysiolog1.27289669
40MP0001346_abnormal_lacrimal_gland1.21532473
41MP0000631_abnormal_neuroendocrine_gland1.18732111
42MP0004957_abnormal_blastocyst_morpholog1.17767834
43MP0002697_abnormal_eye_size1.17762116
44MP0004142_abnormal_muscle_tone1.14136432
45MP0001286_abnormal_eye_development1.13993719
46MP0000026_abnormal_inner_ear1.12667665
47MP0009250_abnormal_appendicular_skeleto1.11556125
48MP0002095_abnormal_skin_pigmentation1.09533780
49MP0002876_abnormal_thyroid_physiology1.07613168
50MP0008058_abnormal_DNA_repair1.03914205
51MP0008875_abnormal_xenobiotic_pharmacok1.02900716
52MP0003718_maternal_effect1.01879215
53MP0001879_abnormal_lymphatic_vessel1.00676764
54MP0005646_abnormal_pituitary_gland0.99272316
55MP0003077_abnormal_cell_cycle0.93592267
56MP0002928_abnormal_bile_duct0.93347533
57MP0005195_abnormal_posterior_eye0.90041805
58MP0009697_abnormal_copulation0.89173439
59MP0005391_vision/eye_phenotype0.88974007
60MP0005171_absent_coat_pigmentation0.88517555
61MP0003646_muscle_fatigue0.88285080
62MP0000778_abnormal_nervous_system0.87790002
63MP0003186_abnormal_redox_activity0.87577351
64MP0004145_abnormal_muscle_electrophysio0.86083413
65MP0010094_abnormal_chromosome_stability0.85796983
66MP0003786_premature_aging0.84340081
67MP0001986_abnormal_taste_sensitivity0.83785461
68MP0002210_abnormal_sex_determination0.83348841
69MP0005671_abnormal_response_to0.83316251
70MP0000490_abnormal_crypts_of0.83045036
71MP0002736_abnormal_nociception_after0.82320721
72MP0003119_abnormal_digestive_system0.80048583
73MP0003880_abnormal_central_pattern0.79169555
74MP0001529_abnormal_vocalization0.78914336
75MP0005389_reproductive_system_phenotype0.78146142
76MP0005197_abnormal_uvea_morphology0.78129205
77MP0002557_abnormal_social/conspecific_i0.77780628
78MP0008789_abnormal_olfactory_epithelium0.76212167
79MP0001905_abnormal_dopamine_level0.75437899
80MP0005187_abnormal_penis_morphology0.74644528
81MP0004019_abnormal_vitamin_homeostasis0.73317284
82MP0002138_abnormal_hepatobiliary_system0.72584786
83MP0000762_abnormal_tongue_morphology0.72266756
84MP0003638_abnormal_response/metabolism_0.71727573
85MP0005408_hypopigmentation0.71494435
86MP0001119_abnormal_female_reproductive0.70810076
87MP0002111_abnormal_tail_morphology0.70131458
88MP0002752_abnormal_somatic_nervous0.68580639
89MP0001963_abnormal_hearing_physiology0.68502242
90MP0009053_abnormal_anal_canal0.68364352
91MP0010386_abnormal_urinary_bladder0.65875423
92MP0005360_urolithiasis0.64447466
93MP0005075_abnormal_melanosome_morpholog0.64398046
94MP0000653_abnormal_sex_gland0.62082354
95MP0008872_abnormal_physiological_respon0.61091509
96MP0001929_abnormal_gametogenesis0.59815598
97MP0005645_abnormal_hypothalamus_physiol0.59180337
98MP0005423_abnormal_somatic_nervous0.58329783
99MP0003942_abnormal_urinary_system0.57768836
100MP0000647_abnormal_sebaceous_gland0.57070105

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.34933704
2Abnormality of cells of the erythroid lineage (HP:0012130)5.33036081
3Abnormal number of erythroid precursors (HP:0012131)5.11208618
4Macrocytic anemia (HP:0001972)4.77194324
5Increased hepatocellular lipid droplets (HP:0006565)4.76855975
6Lipid accumulation in hepatocytes (HP:0006561)4.39467251
7Acute necrotizing encephalopathy (HP:0006965)4.34718454
8Renal Fanconi syndrome (HP:0001994)4.20884173
9Mitochondrial inheritance (HP:0001427)3.91693685
10Acute encephalopathy (HP:0006846)3.81194348
11Pallor (HP:0000980)3.76984647
12Abnormal mitochondria in muscle tissue (HP:0008316)3.61675835
13Congenital, generalized hypertrichosis (HP:0004540)3.54486629
14Progressive macrocephaly (HP:0004481)3.50532565
15Exertional dyspnea (HP:0002875)3.39483790
16Congenital stationary night blindness (HP:0007642)3.35604346
17Increased CSF lactate (HP:0002490)3.24074248
18Pancreatic cysts (HP:0001737)3.21123667
19True hermaphroditism (HP:0010459)3.06401392
20Pancreatic fibrosis (HP:0100732)2.98328696
21Partial duplication of the phalanx of hand (HP:0009999)2.97246314
22Generalized aminoaciduria (HP:0002909)2.95682348
23Respiratory difficulties (HP:0002880)2.93913448
24Partial duplication of thumb phalanx (HP:0009944)2.89478798
25Increased intramyocellular lipid droplets (HP:0012240)2.85374966
26Duplicated collecting system (HP:0000081)2.81922826
27Abnormality of the renal collecting system (HP:0004742)2.80354719
28Aplastic anemia (HP:0001915)2.80298425
29Abnormality of renal resorption (HP:0011038)2.79651660
30Septo-optic dysplasia (HP:0100842)2.79086740
31Abnormality of urine glucose concentration (HP:0011016)2.73567471
32Glycosuria (HP:0003076)2.73567471
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71868166
34Cerebral edema (HP:0002181)2.70399758
35Absent thumb (HP:0009777)2.61989726
36Duplication of thumb phalanx (HP:0009942)2.59104949
37Colon cancer (HP:0003003)2.58987898
38Hepatic necrosis (HP:0002605)2.49177845
39Abnormality of the parietal bone (HP:0002696)2.44016000
40Hepatocellular necrosis (HP:0001404)2.38121114
41Triphalangeal thumb (HP:0001199)2.36122525
42Sclerocornea (HP:0000647)2.35517129
43Hyperphosphaturia (HP:0003109)2.35365862
44Increased muscle lipid content (HP:0009058)2.33177999
45Hyperglycinemia (HP:0002154)2.28428330
46Renal cortical cysts (HP:0000803)2.25843667
47Abnormality of midbrain morphology (HP:0002418)2.23369733
48Molar tooth sign on MRI (HP:0002419)2.23369733
49Stenosis of the external auditory canal (HP:0000402)2.19071790
50Optic disc pallor (HP:0000543)2.17782009
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15317977
52Depressed nasal ridge (HP:0000457)2.11802889
53Oral leukoplakia (HP:0002745)2.08282856
54Cystic liver disease (HP:0006706)2.08159928
55Meckel diverticulum (HP:0002245)2.08054552
56Morphological abnormality of the inner ear (HP:0011390)2.06679582
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05272243
58Abnormality of the ileum (HP:0001549)2.04660531
59Anencephaly (HP:0002323)2.02223688
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00278901
61Bilateral microphthalmos (HP:0007633)1.99726679
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.99604123
63Pendular nystagmus (HP:0012043)1.98340823
64Short hallux (HP:0010109)1.93333184
65Abdominal situs inversus (HP:0003363)1.93216765
66Abnormality of abdominal situs (HP:0011620)1.93216765
67Aplasia/Hypoplasia of the hallux (HP:0008362)1.93170346
68Maternal diabetes (HP:0009800)1.91669266
69Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90856844
70Medial flaring of the eyebrow (HP:0010747)1.89749192
713-Methylglutaconic aciduria (HP:0003535)1.86355326
72Nephronophthisis (HP:0000090)1.85708841
73Abnormality of the labia minora (HP:0012880)1.84793852
74Rib fusion (HP:0000902)1.83417039
75Abnormality of the lacrimal duct (HP:0011481)1.81931707
76Absent septum pellucidum (HP:0001331)1.81764732
77Abnormality of the nasolacrimal system (HP:0000614)1.81085590
78Pancytopenia (HP:0001876)1.78177655
79Leukodystrophy (HP:0002415)1.77761239
80Abnormal urine phosphate concentration (HP:0012599)1.77479153
81Abnormal number of incisors (HP:0011064)1.77083492
82Lactic acidosis (HP:0003128)1.76786915
83Chromsome breakage (HP:0040012)1.75245353
84Respiratory distress (HP:0002098)1.75153650
85Abnormal rod and cone electroretinograms (HP:0008323)1.73730607
86Hypoplasia of the pons (HP:0012110)1.73314941
87Abnormality of the renal cortex (HP:0011035)1.73246346
88Abnormality of the middle phalanges of the toes (HP:0010183)1.72914588
89Exercise intolerance (HP:0003546)1.71637540
90Abnormality of the pons (HP:0007361)1.70536919
91Esophageal atresia (HP:0002032)1.70508655
92Nasolacrimal duct obstruction (HP:0000579)1.70076557
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.69337342
94Hypoplasia of the radius (HP:0002984)1.66672624
95Abnormality of cochlea (HP:0000375)1.66373983
96Concave nail (HP:0001598)1.66188110
97Nausea (HP:0002018)1.61276425
98Increased serum lactate (HP:0002151)1.61015261
99Abnormality of reticulocytes (HP:0004312)1.59960355
100Abnormal ciliary motility (HP:0012262)1.59500600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.91879750
2TAOK33.83375702
3BUB13.21014985
4VRK13.07469688
5PASK3.06202196
6ZAK3.04266193
7TXK2.97783774
8TLK12.76747801
9NUAK12.37267409
10CDC72.27867683
11GRK12.27480871
12EPHB22.25610269
13NME12.24009946
14TAF12.22318051
15WEE12.09670343
16STK161.68695356
17PNCK1.67333386
18PLK31.66897462
19MAP4K11.61840701
20ADRBK21.59973833
21MKNK11.55326591
22BCKDK1.54738188
23TNIK1.49565919
24MAPK151.48054445
25MKNK21.41594438
26PBK1.40697900
27SRPK11.39061667
28TGFBR11.38343051
29PLK41.34111937
30NEK21.30253202
31TSSK61.26791601
32DYRK31.24637037
33DYRK21.24122236
34CASK1.23290588
35WNK41.13499621
36WNK31.10966970
37TTK1.03003244
38STK241.00531263
39FGFR20.98789928
40RPS6KA40.97133832
41MAP3K40.91117852
42NEK10.89362929
43CHEK20.88342172
44CDK190.86342174
45AURKB0.85247950
46PLK10.78462053
47INSRR0.76761001
48TIE10.76008362
49AURKA0.74978176
50CSNK2A20.73725602
51RPS6KA50.73693690
52ADRBK10.70492992
53MAP3K100.67637510
54FGFR10.65398189
55NME20.65142598
56MAP2K70.64692178
57DAPK30.64009919
58PRKCG0.63045225
59ATR0.60110655
60STK40.58513329
61KDR0.58078026
62CSNK2A10.57451171
63CDK30.53232872
64NTRK20.52618983
65ALK0.52293960
66CSNK1E0.50838821
67CDK80.50168021
68MAPKAPK50.50113615
69PRKACA0.47760938
70MAP4K20.47684483
71TESK20.46459768
72PDK20.46307392
73EIF2AK20.44096391
74FLT30.42998652
75KIT0.42852374
76ERBB20.39841398
77STK30.38892194
78CHEK10.38581215
79MUSK0.38556171
80PRKCH0.35501664
81CSNK1A10.35375270
82PRKCQ0.34751149
83NLK0.33849062
84TYRO30.32336329
85OBSCN0.31786449
86RPS6KB20.31217007
87BRSK20.30988633
88PIK3CA0.30404571
89UHMK10.30393443
90STK390.29147066
91PRKG20.27927181
92GRK70.27833059
93SYK0.27486523
94PRKG10.27483096
95TEC0.27340690
96LRRK20.26662701
97PRKCE0.26605845
98MAP2K60.26471566
99DYRK1A0.25842486
100GRK60.25803811

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.76013547
2Oxidative phosphorylation_Homo sapiens_hsa001904.67550939
3Parkinsons disease_Homo sapiens_hsa050123.92048594
4Proteasome_Homo sapiens_hsa030503.05313060
5Alzheimers disease_Homo sapiens_hsa050102.78967564
6Huntingtons disease_Homo sapiens_hsa050162.74374984
7Protein export_Homo sapiens_hsa030602.59428760
8Cardiac muscle contraction_Homo sapiens_hsa042602.45602029
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42353796
10RNA polymerase_Homo sapiens_hsa030202.42340805
11Spliceosome_Homo sapiens_hsa030402.09333144
12Mismatch repair_Homo sapiens_hsa034301.84772134
13Homologous recombination_Homo sapiens_hsa034401.63138242
14RNA degradation_Homo sapiens_hsa030181.52746027
15DNA replication_Homo sapiens_hsa030301.48455417
16Nitrogen metabolism_Homo sapiens_hsa009101.47531141
17Basal transcription factors_Homo sapiens_hsa030221.44524591
18Linoleic acid metabolism_Homo sapiens_hsa005911.44385266
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39488563
20RNA transport_Homo sapiens_hsa030131.35379080
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29696587
22Fanconi anemia pathway_Homo sapiens_hsa034601.26051020
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22986912
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21264737
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.16433894
26Selenocompound metabolism_Homo sapiens_hsa004501.16206365
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15302267
28Phototransduction_Homo sapiens_hsa047441.14109616
29Nucleotide excision repair_Homo sapiens_hsa034201.13189392
30Pyrimidine metabolism_Homo sapiens_hsa002401.10977886
31One carbon pool by folate_Homo sapiens_hsa006701.10734099
32Purine metabolism_Homo sapiens_hsa002301.05601136
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04169254
34Sulfur relay system_Homo sapiens_hsa041221.02192763
35Systemic lupus erythematosus_Homo sapiens_hsa053220.95312255
36Basal cell carcinoma_Homo sapiens_hsa052170.94500957
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89202856
38Primary immunodeficiency_Homo sapiens_hsa053400.85020631
39Base excision repair_Homo sapiens_hsa034100.84141805
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78018568
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.76724063
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75024504
43Folate biosynthesis_Homo sapiens_hsa007900.74383510
44Vitamin digestion and absorption_Homo sapiens_hsa049770.68592528
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67922814
46Asthma_Homo sapiens_hsa053100.67505844
47Ether lipid metabolism_Homo sapiens_hsa005650.66751257
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66450223
49mRNA surveillance pathway_Homo sapiens_hsa030150.65211894
50Nicotine addiction_Homo sapiens_hsa050330.65011638
51Metabolic pathways_Homo sapiens_hsa011000.64352477
52Caffeine metabolism_Homo sapiens_hsa002320.64243948
53Glutathione metabolism_Homo sapiens_hsa004800.64076113
54Allograft rejection_Homo sapiens_hsa053300.62158261
55Chemical carcinogenesis_Homo sapiens_hsa052040.61328333
56Olfactory transduction_Homo sapiens_hsa047400.61272656
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61218168
58Retinol metabolism_Homo sapiens_hsa008300.61046489
59Autoimmune thyroid disease_Homo sapiens_hsa053200.57855920
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56030665
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54323436
62Peroxisome_Homo sapiens_hsa041460.53874726
63Tyrosine metabolism_Homo sapiens_hsa003500.53212323
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52745023
65Fat digestion and absorption_Homo sapiens_hsa049750.52354668
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.51338210
67Arachidonic acid metabolism_Homo sapiens_hsa005900.50870561
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.49218546
69Hedgehog signaling pathway_Homo sapiens_hsa043400.46165257
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45400019
71Butanoate metabolism_Homo sapiens_hsa006500.41314768
72Cell cycle_Homo sapiens_hsa041100.41115249
73Type I diabetes mellitus_Homo sapiens_hsa049400.39551684
74Alcoholism_Homo sapiens_hsa050340.39079353
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.38627882
76Graft-versus-host disease_Homo sapiens_hsa053320.38283915
77Taste transduction_Homo sapiens_hsa047420.37900389
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37446493
79Tryptophan metabolism_Homo sapiens_hsa003800.36720522
80Propanoate metabolism_Homo sapiens_hsa006400.36646689
81Pyruvate metabolism_Homo sapiens_hsa006200.36101580
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35329094
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33182120
84Protein digestion and absorption_Homo sapiens_hsa049740.32795776
85Collecting duct acid secretion_Homo sapiens_hsa049660.31960523
86Antigen processing and presentation_Homo sapiens_hsa046120.30647140
87p53 signaling pathway_Homo sapiens_hsa041150.29574915
88Non-homologous end-joining_Homo sapiens_hsa034500.27394585
89Hematopoietic cell lineage_Homo sapiens_hsa046400.26890489
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26722025
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26470441
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24908520
93Rheumatoid arthritis_Homo sapiens_hsa053230.22462844
94Serotonergic synapse_Homo sapiens_hsa047260.22436439
95Mineral absorption_Homo sapiens_hsa049780.20763299
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20175911
97Cocaine addiction_Homo sapiens_hsa050300.19325827
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.18865627
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17270860
100Regulation of autophagy_Homo sapiens_hsa041400.16818565

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