RPL14P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.95697385
2translational termination (GO:0006415)5.70097918
3ribosomal small subunit assembly (GO:0000028)5.41883536
4ATP synthesis coupled proton transport (GO:0015986)5.28823478
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.28823478
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.16217789
7cotranslational protein targeting to membrane (GO:0006613)5.09904601
8protein targeting to ER (GO:0045047)5.07601667
9DNA deamination (GO:0045006)5.07194353
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.06662273
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.97380148
12translational elongation (GO:0006414)4.90118314
13chaperone-mediated protein transport (GO:0072321)4.89542501
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.83427890
15protein localization to endoplasmic reticulum (GO:0070972)4.73867441
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.63796554
17GTP biosynthetic process (GO:0006183)4.53501798
18ribosomal small subunit biogenesis (GO:0042274)4.49306265
19NADH dehydrogenase complex assembly (GO:0010257)4.41004666
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.41004666
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.41004666
22cellular protein complex disassembly (GO:0043624)4.30457796
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.27093503
24respiratory electron transport chain (GO:0022904)4.23816040
25viral life cycle (GO:0019058)4.20656082
26electron transport chain (GO:0022900)4.19159664
27maturation of SSU-rRNA (GO:0030490)4.13878306
28translational initiation (GO:0006413)4.07744859
29protein complex biogenesis (GO:0070271)3.89984037
30epithelial cilium movement (GO:0003351)3.88279039
31UTP biosynthetic process (GO:0006228)3.86036507
32ribosomal large subunit biogenesis (GO:0042273)3.77253573
33proteasome assembly (GO:0043248)3.69822779
34translation (GO:0006412)3.69140013
35protein-cofactor linkage (GO:0018065)3.68769485
36mitochondrial respiratory chain complex assembly (GO:0033108)3.67465071
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.66296642
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.66296642
39protein complex disassembly (GO:0043241)3.61281210
40activation of MAPKKK activity (GO:0000185)3.53805724
41inner mitochondrial membrane organization (GO:0007007)3.52271981
42macromolecular complex disassembly (GO:0032984)3.49471724
43sequestering of actin monomers (GO:0042989)3.46780584
44UTP metabolic process (GO:0046051)3.45665484
45protein neddylation (GO:0045116)3.44977267
46resolution of meiotic recombination intermediates (GO:0000712)3.41621751
47positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.41117745
48leukocyte aggregation (GO:0070486)3.39657075
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36809438
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30296336
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.26492735
52termination of RNA polymerase III transcription (GO:0006386)3.26492735
53protein targeting to membrane (GO:0006612)3.25472061
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24423406
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21344939
56axonemal dynein complex assembly (GO:0070286)3.19654473
57behavioral response to nicotine (GO:0035095)3.18869125
58CTP metabolic process (GO:0046036)3.17162876
59CTP biosynthetic process (GO:0006241)3.17162876
60water-soluble vitamin biosynthetic process (GO:0042364)3.13797232
61cilium movement (GO:0003341)3.12395237
62nuclear-transcribed mRNA catabolic process (GO:0000956)3.10756171
63guanosine-containing compound biosynthetic process (GO:1901070)3.08260267
64rRNA metabolic process (GO:0016072)3.03853031
65mRNA catabolic process (GO:0006402)2.94481354
66pyrimidine nucleotide catabolic process (GO:0006244)2.91749969
67cellular component biogenesis (GO:0044085)2.88884649
68nucleoside diphosphate phosphorylation (GO:0006165)2.88495977
69organelle disassembly (GO:1903008)2.86905208
70hydrogen ion transmembrane transport (GO:1902600)2.86568652
71DNA damage response, detection of DNA damage (GO:0042769)2.86097681
72regulation of isotype switching to IgG isotypes (GO:0048302)2.85850689
73protein targeting to mitochondrion (GO:0006626)2.85637960
74pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85249670
75ATP biosynthetic process (GO:0006754)2.83661809
76ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81203047
77rRNA processing (GO:0006364)2.80002359
78pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.78521268
79establishment of protein localization to mitochondrion (GO:0072655)2.77437906
80pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.76012328
81pseudouridine synthesis (GO:0001522)2.75692708
82intracellular protein transmembrane import (GO:0044743)2.75461734
83proton transport (GO:0015992)2.72481642
84protein localization to mitochondrion (GO:0070585)2.71721491
85meiotic chromosome segregation (GO:0045132)2.69404425
86positive regulation of defense response to virus by host (GO:0002230)2.69377536
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69358298
88attachment of spindle microtubules to kinetochore (GO:0008608)2.68532530
89regulation of cellular amino acid metabolic process (GO:0006521)2.67523678
90termination of RNA polymerase I transcription (GO:0006363)2.67117306
91positive regulation of DNA recombination (GO:0045911)2.67047865
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66211026
93hydrogen transport (GO:0006818)2.66181699
94negative regulation of telomere maintenance (GO:0032205)2.65752392
95rRNA transcription (GO:0009303)2.65543317
967-methylguanosine mRNA capping (GO:0006370)2.64766357
97ribonucleoprotein complex biogenesis (GO:0022613)2.64315462
98piRNA metabolic process (GO:0034587)2.64308738
99reciprocal meiotic recombination (GO:0007131)2.61457492
100reciprocal DNA recombination (GO:0035825)2.61457492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67845337
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.26531562
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.74100142
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65172893
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.22866734
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19598154
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16178965
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90475328
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.74994449
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60831097
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58856192
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55201966
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54190450
14VDR_22108803_ChIP-Seq_LS180_Human2.43254678
15VDR_23849224_ChIP-Seq_CD4+_Human2.37378674
16EZH2_22144423_ChIP-Seq_EOC_Human2.33648911
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.15998456
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10529840
19FOXP3_21729870_ChIP-Seq_TREG_Human2.03165398
20ZNF274_21170338_ChIP-Seq_K562_Hela1.83080136
21ELK1_19687146_ChIP-ChIP_HELA_Human1.82163206
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.75666615
23EWS_26573619_Chip-Seq_HEK293_Human1.71166127
24TP53_22573176_ChIP-Seq_HFKS_Human1.70426838
25MYC_18940864_ChIP-ChIP_HL60_Human1.67979287
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.67854323
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63730091
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56875428
29GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.55955880
30TTF2_22483619_ChIP-Seq_HELA_Human1.54385912
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53995885
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50501439
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50363853
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47912846
35XRN2_22483619_ChIP-Seq_HELA_Human1.45584154
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.44563526
37FUS_26573619_Chip-Seq_HEK293_Human1.42674472
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.40360815
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37164710
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.36719793
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36719793
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36540411
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30433246
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29570372
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.27474408
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26265917
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25308455
48GABP_19822575_ChIP-Seq_HepG2_Human1.21313798
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20564013
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18563861
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.18156230
52AR_20517297_ChIP-Seq_VCAP_Human1.17757343
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.17485433
54TAF2_19829295_ChIP-Seq_ESCs_Human1.16993539
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16366503
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13373699
57NCOR_22424771_ChIP-Seq_293T_Human1.12853879
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12772992
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12220139
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12056276
61ERG_20517297_ChIP-Seq_VCAP_Human1.12050744
62DCP1A_22483619_ChIP-Seq_HELA_Human1.11632171
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10783010
64IGF1R_20145208_ChIP-Seq_DFB_Human1.10650071
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09803061
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09500202
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09023982
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08305956
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08266501
70PHF8_20622853_ChIP-Seq_HELA_Human1.07647547
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07437017
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.07006607
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06124632
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.04051044
75ER_23166858_ChIP-Seq_MCF-7_Human1.03836934
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03291174
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01173744
78P300_19829295_ChIP-Seq_ESCs_Human0.99655339
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98852120
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97705266
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96443127
82CBP_20019798_ChIP-Seq_JUKART_Human0.96378749
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96378749
84NANOG_20526341_ChIP-Seq_ESCs_Human0.96378112
85STAT1_20625510_ChIP-Seq_HELA_Human0.94208829
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94114174
87IRF1_19129219_ChIP-ChIP_H3396_Human0.92448577
88ERA_21632823_ChIP-Seq_H3396_Human0.92117603
89MYC_19829295_ChIP-Seq_ESCs_Human0.92098600
90TAF15_26573619_Chip-Seq_HEK293_Human0.91886720
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.91628972
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91586887
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90284995
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89650979
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89489300
96RBPJ_21746931_ChIP-Seq_IB4_Human0.88541837
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88339387
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87504621
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87439854
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87025604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.84400674
2MP0009379_abnormal_foot_pigmentation3.55382272
3MP0002102_abnormal_ear_morphology3.08962953
4MP0002938_white_spotting2.98718785
5MP0006292_abnormal_olfactory_placode2.78005999
6MP0005623_abnormal_meninges_morphology2.77980533
7MP0004147_increased_porphyrin_level2.56265542
8MP0008875_abnormal_xenobiotic_pharmacok2.35793667
9MP0005645_abnormal_hypothalamus_physiol2.22911602
10MP0003786_premature_aging2.17402763
11MP0005075_abnormal_melanosome_morpholog2.05405372
12MP0005671_abnormal_response_to2.05133428
13MP0002163_abnormal_gland_morphology2.02870893
14MP0008058_abnormal_DNA_repair2.01095387
15MP0008877_abnormal_DNA_methylation1.98489766
16MP0005551_abnormal_eye_electrophysiolog1.86586073
17MP0002638_abnormal_pupillary_reflex1.81379523
18MP0005646_abnormal_pituitary_gland1.78950130
19MP0002277_abnormal_respiratory_mucosa1.71895688
20MP0002822_catalepsy1.62353875
21MP0004742_abnormal_vestibular_system1.61075770
22MP0000631_abnormal_neuroendocrine_gland1.60701909
23MP0008872_abnormal_physiological_respon1.58640243
24MP0003011_delayed_dark_adaptation1.55111072
25MP0004381_abnormal_hair_follicle1.53437306
26MP0001905_abnormal_dopamine_level1.52143233
27MP0001984_abnormal_olfaction1.46548674
28MP0003283_abnormal_digestive_organ1.43535037
29MP0009384_cardiac_valve_regurgitation1.42446729
30MP0004142_abnormal_muscle_tone1.42205342
31MP0001873_stomach_inflammation1.38756980
32MP0001835_abnormal_antigen_presentation1.38360493
33MP0002234_abnormal_pharynx_morphology1.37214791
34MP0005377_hearing/vestibular/ear_phenot1.35488455
35MP0003878_abnormal_ear_physiology1.35488455
36MP0000013_abnormal_adipose_tissue1.34911663
37MP0003186_abnormal_redox_activity1.31198573
38MP0000372_irregular_coat_pigmentation1.29769581
39MP0005408_hypopigmentation1.29005372
40MP0003787_abnormal_imprinting1.28750591
41MP0008789_abnormal_olfactory_epithelium1.27642736
42MP0002736_abnormal_nociception_after1.27446619
43MP0001485_abnormal_pinna_reflex1.26147326
44MP0001293_anophthalmia1.25768207
45MP0002272_abnormal_nervous_system1.23485742
46MP0003646_muscle_fatigue1.22790152
47MP0003195_calcinosis1.19899943
48MP0005379_endocrine/exocrine_gland_phen1.19164108
49MP0001486_abnormal_startle_reflex1.18866422
50MP0002653_abnormal_ependyma_morphology1.14206074
51MP0004145_abnormal_muscle_electrophysio1.14129392
52MP0002837_dystrophic_cardiac_calcinosis1.11361685
53MP0005084_abnormal_gallbladder_morpholo1.07460952
54MP0001529_abnormal_vocalization1.07054421
55MP0002876_abnormal_thyroid_physiology1.05929193
56MP0006072_abnormal_retinal_apoptosis1.04502200
57MP0002210_abnormal_sex_determination1.04496897
58MP0001502_abnormal_circadian_rhythm1.04355165
59MP0009745_abnormal_behavioral_response1.03243015
60MP0008995_early_reproductive_senescence1.03145726
61MP0005387_immune_system_phenotype1.03001802
62MP0001790_abnormal_immune_system1.03001802
63MP0005195_abnormal_posterior_eye1.00946194
64MP0006036_abnormal_mitochondrial_physio1.00895205
65MP0001968_abnormal_touch/_nociception1.00579897
66MP0006276_abnormal_autonomic_nervous0.99988367
67MP0000750_abnormal_muscle_regeneration0.99604049
68MP0003959_abnormal_lean_body0.99324661
69MP0003137_abnormal_impulse_conducting0.96634453
70MP0000026_abnormal_inner_ear0.95837542
71MP0002067_abnormal_sensory_capabilities0.94960529
72MP0002095_abnormal_skin_pigmentation0.94678608
73MP0000685_abnormal_immune_system0.94200679
74MP0004885_abnormal_endolymph0.93925734
75MP0002160_abnormal_reproductive_system0.93596737
76MP0003806_abnormal_nucleotide_metabolis0.91287397
77MP0005394_taste/olfaction_phenotype0.87890077
78MP0005499_abnormal_olfactory_system0.87890077
79MP0001800_abnormal_humoral_immune0.87293994
80MP0003698_abnormal_male_reproductive0.87004286
81MP0001929_abnormal_gametogenesis0.85790584
82MP0001324_abnormal_eye_pigmentation0.82612083
83MP0005389_reproductive_system_phenotype0.82303439
84MP0000653_abnormal_sex_gland0.81810008
85MP0000778_abnormal_nervous_system0.81455742
86MP0002572_abnormal_emotion/affect_behav0.81431792
87MP0005410_abnormal_fertilization0.80991246
88MP0000049_abnormal_middle_ear0.80620844
89MP0005253_abnormal_eye_physiology0.78905008
90MP0001188_hyperpigmentation0.78163886
91MP0001145_abnormal_male_reproductive0.77456238
92MP0002751_abnormal_autonomic_nervous0.77072720
93MP0003718_maternal_effect0.77014780
94MP0001501_abnormal_sleep_pattern0.76919298
95MP0006035_abnormal_mitochondrial_morpho0.75678955
96MP0003880_abnormal_central_pattern0.75390133
97MP0001986_abnormal_taste_sensitivity0.74423022
98MP0002177_abnormal_outer_ear0.74185879
99MP0002132_abnormal_respiratory_system0.73411849
100MP0009333_abnormal_splenocyte_physiolog0.72770065

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)6.17736443
2Cerebellar dysplasia (HP:0007033)6.08856776
3Hypoplasia of the pons (HP:0012110)5.30378995
4Retinal atrophy (HP:0001105)5.29542133
5Abnormality of the pons (HP:0007361)4.91453414
6Acute necrotizing encephalopathy (HP:0006965)4.67246175
7Retinal dysplasia (HP:0007973)4.54678875
8Progressive macrocephaly (HP:0004481)4.16391310
9Acute encephalopathy (HP:0006846)4.05861141
10Abnormal mitochondria in muscle tissue (HP:0008316)3.94720920
11Mitochondrial inheritance (HP:0001427)3.90880837
12Decreased electroretinogram (ERG) amplitude (HP:0000654)3.76424265
13Abolished electroretinogram (ERG) (HP:0000550)3.45237649
14Increased CSF lactate (HP:0002490)3.39986078
15Aplasia/Hypoplasia affecting the retina (HP:0008061)3.35809041
16Nephronophthisis (HP:0000090)3.19658933
17Abnormality of midbrain morphology (HP:0002418)3.10211359
18Molar tooth sign on MRI (HP:0002419)3.10211359
19Increased hepatocellular lipid droplets (HP:0006565)3.07810803
20Fatigue (HP:0012378)2.96556150
21Lipid accumulation in hepatocytes (HP:0006561)2.92979492
223-Methylglutaconic aciduria (HP:0003535)2.90052926
23IgG deficiency (HP:0004315)2.88906317
24Cerebral edema (HP:0002181)2.83514953
25Abnormality of cells of the erythroid lineage (HP:0012130)2.80364497
26Pallor (HP:0000980)2.75738539
27Congenital stationary night blindness (HP:0007642)2.73476099
28Medial flaring of the eyebrow (HP:0010747)2.72190096
29Severe muscular hypotonia (HP:0006829)2.70150411
30Abnormality of DNA repair (HP:0003254)2.67409114
31Entropion (HP:0000621)2.65892531
32Hepatocellular necrosis (HP:0001404)2.61141238
33Abnormality of the renal cortex (HP:0011035)2.60297296
34True hermaphroditism (HP:0010459)2.58261083
35Abnormal number of erythroid precursors (HP:0012131)2.58249457
36Abnormality of the renal medulla (HP:0100957)2.58241672
37Lissencephaly (HP:0001339)2.56734404
38Pancreatic cysts (HP:0001737)2.55898012
39Reticulocytopenia (HP:0001896)2.54641142
40Absent/shortened dynein arms (HP:0200106)2.49972503
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.49972503
42Increased IgM level (HP:0003496)2.48041655
43Hepatic necrosis (HP:0002605)2.47478084
44Pancreatic fibrosis (HP:0100732)2.47081428
45Testicular atrophy (HP:0000029)2.45021525
46Buphthalmos (HP:0000557)2.43120681
47Abnormal respiratory epithelium morphology (HP:0012253)2.39580372
48Abnormal respiratory motile cilium morphology (HP:0005938)2.39580372
49Abnormal drinking behavior (HP:0030082)2.38951200
50Polydipsia (HP:0001959)2.38951200
51Macrocytic anemia (HP:0001972)2.37777637
52Abnormal ciliary motility (HP:0012262)2.29142997
53Congenital, generalized hypertrichosis (HP:0004540)2.26674618
54Optic disc pallor (HP:0000543)2.26140680
55Exertional dyspnea (HP:0002875)2.24914806
56Abnormal respiratory motile cilium physiology (HP:0012261)2.24700492
57Renal Fanconi syndrome (HP:0001994)2.17937141
58Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.17490011
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.15004648
60Chronic hepatic failure (HP:0100626)2.08700414
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05745254
62Leukodystrophy (HP:0002415)2.03816296
63Chronic sinusitis (HP:0011109)2.03484646
64Pachygyria (HP:0001302)2.03094710
65Tubular atrophy (HP:0000092)1.99542945
66Submucous cleft hard palate (HP:0000176)1.97006336
67Asplenia (HP:0001746)1.96083565
68Respiratory failure (HP:0002878)1.96074666
69Difficulty climbing stairs (HP:0003551)1.95661535
70Lactic acidosis (HP:0003128)1.95504453
71Septo-optic dysplasia (HP:0100842)1.94801993
72Stomatitis (HP:0010280)1.93560354
73Increased serum lactate (HP:0002151)1.93149977
74Abnormality of the vitreous humor (HP:0004327)1.91490938
75Lethargy (HP:0001254)1.90117506
76Sclerocornea (HP:0000647)1.88784572
77Decreased subcutaneous fat (HP:0001002)1.84639312
78Intellectual disability, profound (HP:0002187)1.84477016
79Non-midline cleft lip (HP:0100335)1.84327795
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.84298476
81Abnormality of alanine metabolism (HP:0010916)1.82253837
82Hyperalaninemia (HP:0003348)1.82253837
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82253837
84Dyschromatopsia (HP:0007641)1.82051995
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81471259
86Poikiloderma (HP:0001029)1.79101851
87Abnormality of urine glucose concentration (HP:0011016)1.78285573
88Glycosuria (HP:0003076)1.78285573
89Polyuria (HP:0000103)1.76528517
90Abnormality of the metopic suture (HP:0005556)1.75941678
91Abdominal situs inversus (HP:0003363)1.75844730
92Abnormality of abdominal situs (HP:0011620)1.75844730
93Maternal diabetes (HP:0009800)1.74537381
94Exercise intolerance (HP:0003546)1.74495802
95Optic nerve hypoplasia (HP:0000609)1.72699794
96Mesangial abnormality (HP:0001966)1.70013056
97Hypoplasia of the brainstem (HP:0002365)1.69633191
98Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69633191
99Prominent metopic ridge (HP:0005487)1.68607315
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68549348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.07858929
2MARK33.75035422
3VRK22.96534092
4STK102.90322209
5MAP3K122.73398880
6NUAK12.64070738
7NEK12.31710738
8FRK2.23349947
9TAOK32.16570206
10TLK12.08625651
11VRK12.00056551
12TSSK61.97800708
13PASK1.84781974
14MAP4K11.76354906
15WNK41.72658519
16ADRBK21.68376169
17CDK191.65851505
18TNIK1.59549478
19DYRK21.54945776
20NME11.50576567
21STK161.49908811
22MAPK151.48526183
23GRK11.45765670
24NLK1.41193441
25WNK31.36086557
26MAP3K111.33892127
27SRPK11.31900022
28ZAK1.31351314
29MAP4K21.31284169
30STK391.30746333
31TRIM281.28348255
32STK111.18440336
33PTK2B1.17023588
34PIM11.16249403
35MKNK11.14130038
36PINK11.11542776
37OXSR11.11236145
38INSRR1.10665339
39MAPK131.05537459
40PLK41.02728644
41TAF11.02611698
42BUB10.99349221
43EIF2AK30.98084383
44CSNK1G30.95999965
45CAMKK20.93385844
46MKNK20.93332125
47IKBKB0.88587623
48RPS6KA50.87012819
49PHKG20.85346244
50PHKG10.85346244
51PLK30.84768030
52PRKCG0.84721829
53PIK3CG0.83088808
54MAP3K40.82608942
55CSNK1G20.77622282
56DAPK10.77265006
57CCNB10.74362587
58EIF2AK10.72238702
59CSNK1G10.72112005
60PRKCH0.72028192
61PNCK0.71206312
62DAPK30.70943461
63BCKDK0.67232167
64MUSK0.64785335
65TIE10.62041714
66BMPR1B0.60438809
67LMTK20.59908794
68CSNK1A1L0.59304115
69ILK0.57716066
70CSNK2A20.57288050
71CAMK2A0.55937785
72MAP2K70.53993055
73GSK3A0.53710041
74PBK0.51827627
75ADRBK10.51372232
76NME20.51136812
77EPHA30.50995542
78DYRK30.50821007
79PRKACA0.49693691
80CSNK2A10.49036473
81NTRK20.48961068
82LRRK20.46866199
83MAPKAPK50.46649195
84EIF2AK20.46110744
85WEE10.46077789
86PIK3CA0.40327084
87AURKA0.40176051
88AURKB0.39862501
89IRAK40.38515991
90BMPR20.37527401
91GRK50.35557794
92FGFR20.35201183
93OBSCN0.35155779
94ITK0.35026530
95PRKCE0.34099390
96PKN10.34004669
97TEC0.33992392
98KIT0.33167936
99PRKG10.31788475
100SYK0.31610075

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.22330936
2Oxidative phosphorylation_Homo sapiens_hsa001904.33256492
3Parkinsons disease_Homo sapiens_hsa050123.68395710
4Proteasome_Homo sapiens_hsa030503.64689802
5RNA polymerase_Homo sapiens_hsa030202.98523936
6Protein export_Homo sapiens_hsa030602.93838962
7Huntingtons disease_Homo sapiens_hsa050162.73422337
8Alzheimers disease_Homo sapiens_hsa050102.42669521
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27509708
10Homologous recombination_Homo sapiens_hsa034402.16279288
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08311667
12Cardiac muscle contraction_Homo sapiens_hsa042601.93431613
13Asthma_Homo sapiens_hsa053101.76303161
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74207430
15Pyrimidine metabolism_Homo sapiens_hsa002401.68617522
16Allograft rejection_Homo sapiens_hsa053301.62442208
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.59977442
18Mismatch repair_Homo sapiens_hsa034301.59000500
19One carbon pool by folate_Homo sapiens_hsa006701.56118060
20Basal transcription factors_Homo sapiens_hsa030221.54750973
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51833376
22Nucleotide excision repair_Homo sapiens_hsa034201.44832783
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.44544730
24Autoimmune thyroid disease_Homo sapiens_hsa053201.43948016
25Primary immunodeficiency_Homo sapiens_hsa053401.32334420
26RNA degradation_Homo sapiens_hsa030181.30428286
27Spliceosome_Homo sapiens_hsa030401.30174596
28Butanoate metabolism_Homo sapiens_hsa006501.27857580
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24197726
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22706764
31Caffeine metabolism_Homo sapiens_hsa002321.12997695
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11780807
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10493645
34Fanconi anemia pathway_Homo sapiens_hsa034601.09549265
35Purine metabolism_Homo sapiens_hsa002301.09407232
36Graft-versus-host disease_Homo sapiens_hsa053321.03850847
37Sulfur metabolism_Homo sapiens_hsa009201.03785955
38Linoleic acid metabolism_Homo sapiens_hsa005911.03274433
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02526045
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.97712333
41Nitrogen metabolism_Homo sapiens_hsa009100.96545713
42Sulfur relay system_Homo sapiens_hsa041220.96221043
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95489056
44Type I diabetes mellitus_Homo sapiens_hsa049400.91652076
45Phototransduction_Homo sapiens_hsa047440.87829805
46Chemical carcinogenesis_Homo sapiens_hsa052040.85645354
47Collecting duct acid secretion_Homo sapiens_hsa049660.85234166
48Folate biosynthesis_Homo sapiens_hsa007900.82457555
49Tryptophan metabolism_Homo sapiens_hsa003800.82026830
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80397546
51Peroxisome_Homo sapiens_hsa041460.79752075
52Regulation of autophagy_Homo sapiens_hsa041400.79611989
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.79153786
54DNA replication_Homo sapiens_hsa030300.77326896
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76667910
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76051012
57RNA transport_Homo sapiens_hsa030130.75071431
58Metabolic pathways_Homo sapiens_hsa011000.73515834
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72695033
60Propanoate metabolism_Homo sapiens_hsa006400.71792979
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67879958
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65848160
63Steroid biosynthesis_Homo sapiens_hsa001000.63498240
64Rheumatoid arthritis_Homo sapiens_hsa053230.60874075
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59853161
66Selenocompound metabolism_Homo sapiens_hsa004500.59756792
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59542480
68Base excision repair_Homo sapiens_hsa034100.57234007
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57017914
70Mineral absorption_Homo sapiens_hsa049780.56455360
71Nicotine addiction_Homo sapiens_hsa050330.56363850
72Antigen processing and presentation_Homo sapiens_hsa046120.56266199
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.56099445
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55454594
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53406831
76Retinol metabolism_Homo sapiens_hsa008300.52504492
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52445449
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.51374942
79Systemic lupus erythematosus_Homo sapiens_hsa053220.50465341
80Hematopoietic cell lineage_Homo sapiens_hsa046400.50121107
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49447694
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47856740
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47824502
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.45043851
85Glutathione metabolism_Homo sapiens_hsa004800.42092373
86Fat digestion and absorption_Homo sapiens_hsa049750.41482132
87Vitamin B6 metabolism_Homo sapiens_hsa007500.40803106
88Serotonergic synapse_Homo sapiens_hsa047260.39687174
89Non-homologous end-joining_Homo sapiens_hsa034500.37071584
90Ether lipid metabolism_Homo sapiens_hsa005650.34170400
91Fatty acid elongation_Homo sapiens_hsa000620.32003181
92Arachidonic acid metabolism_Homo sapiens_hsa005900.29602014
93Fatty acid degradation_Homo sapiens_hsa000710.27054553
94Basal cell carcinoma_Homo sapiens_hsa052170.23787313
95Epstein-Barr virus infection_Homo sapiens_hsa051690.23465983
96Olfactory transduction_Homo sapiens_hsa047400.22728684
97Pyruvate metabolism_Homo sapiens_hsa006200.21287598
98Insulin secretion_Homo sapiens_hsa049110.20335512
99Cocaine addiction_Homo sapiens_hsa050300.19722503
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.19378954

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