ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oxygen transport (GO:0015671)	8.54615994
2	gas transport (GO:0015669)	7.42216321
3	ribosomal small subunit biogenesis (GO:0042274)	5.76558862
4	S-adenosylmethionine metabolic process (GO:0046500)	5.67118306
5	ncRNA 3-end processing (GO:0043628)	5.48735738
6	homocysteine metabolic process (GO:0050667)	5.33644023
7	viral transcription (GO:0019083)	5.10320809
8	translational termination (GO:0006415)	4.80863037
9	L-fucose catabolic process (GO:0042355)	4.37236468
10	fucose catabolic process (GO:0019317)	4.37236468
11	L-fucose metabolic process (GO:0042354)	4.37236468
12	regulation of isotype switching to IgG isotypes (GO:0048302)	4.35870458
13	translational elongation (GO:0006414)	4.31273976
14	positive regulation of mitochondrial fission (GO:0090141)	4.18962200
15	ATP synthesis coupled proton transport (GO:0015986)	4.18414688
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.18414688
17	gamma-aminobutyric acid transport (GO:0015812)	4.15687059
18	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.09388797
19	DNA deamination (GO:0045006)	4.07494448
20	cotranslational protein targeting to membrane (GO:0006613)	4.06489837
21	protein targeting to ER (GO:0045047)	4.00955177
22	protein localization to endoplasmic reticulum (GO:0070972)	3.95181525
23	protein-cofactor linkage (GO:0018065)	3.88732980
24	ubiquinone biosynthetic process (GO:0006744)	3.84637146
25	viral life cycle (GO:0019058)	3.80535690
26	single strand break repair (GO:0000012)	3.79343584
27	head development (GO:0060322)	3.76942701
28	regulation of podosome assembly (GO:0071801)	3.75809482
29	maturation of SSU-rRNA (GO:0030490)	3.75199838
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.73651205
31	positive regulation of protein homooligomerization (GO:0032464)	3.73177378
32	GPI anchor biosynthetic process (GO:0006506)	3.72255717
33	dopamine transport (GO:0015872)	3.70985829
34	water-soluble vitamin biosynthetic process (GO:0042364)	3.65882962
35	startle response (GO:0001964)	3.65040440
36	cellular protein complex disassembly (GO:0043624)	3.64006346
37	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.60134661
38	execution phase of apoptosis (GO:0097194)	3.48702213
39	ubiquinone metabolic process (GO:0006743)	3.48250021
40	GPI anchor metabolic process (GO:0006505)	3.48103511
41	organelle disassembly (GO:1903008)	3.48090077
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.45032024
43	inner ear receptor cell differentiation (GO:0060113)	3.37199898
44	UV protection (GO:0009650)	3.35433457
45	folic acid metabolic process (GO:0046655)	3.33456536
46	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.31095172
47	pyrimidine nucleobase catabolic process (GO:0006208)	3.29381301
48	establishment of mitochondrion localization (GO:0051654)	3.28319746
49	positive thymic T cell selection (GO:0045059)	3.27754179
50	mannosylation (GO:0097502)	3.25869335
51	chemokine-mediated signaling pathway (GO:0070098)	3.25324804
52	positive regulation of fatty acid oxidation (GO:0046321)	3.25242279
53	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.24110197
54	mitochondrion transport along microtubule (GO:0047497)	3.24110197
55	photoreceptor cell maintenance (GO:0045494)	3.21833120
56	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.20450578
57	cytokine biosynthetic process (GO:0042089)	3.19292199
58	positive regulation of filopodium assembly (GO:0051491)	3.19259073
59	base-excision repair, AP site formation (GO:0006285)	3.15163462
60	quinone biosynthetic process (GO:1901663)	3.13439525
61	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10504447
62	positive regulation of chemokine biosynthetic process (GO:0045080)	3.08884140
63	protein complex disassembly (GO:0043241)	3.06704204
64	axoneme assembly (GO:0035082)	3.06184640
65	protoporphyrinogen IX metabolic process (GO:0046501)	3.05768952
66	translational initiation (GO:0006413)	3.02941158
67	regulation of triglyceride catabolic process (GO:0010896)	3.00476659
68	regulation of MHC class II biosynthetic process (GO:0045346)	2.99204074
69	GTP biosynthetic process (GO:0006183)	2.98344181
70	ribosomal small subunit assembly (GO:0000028)	2.98141771
71	regulation of immunoglobulin secretion (GO:0051023)	2.97645247
72	C-terminal protein lipidation (GO:0006501)	2.95875039
73	C-terminal protein amino acid modification (GO:0018410)	2.95461922
74	macromolecular complex disassembly (GO:0032984)	2.92355731
75	tolerance induction (GO:0002507)	2.85590196
76	synaptic transmission, cholinergic (GO:0007271)	2.84068940
77	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82950134
78	termination of RNA polymerase III transcription (GO:0006386)	2.82950134
79	N-acetylneuraminate metabolic process (GO:0006054)	2.81965651
80	neuronal action potential propagation (GO:0019227)	2.81412654
81	behavioral response to nicotine (GO:0035095)	2.79682856
82	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.76708112
83	rRNA methylation (GO:0031167)	2.75096599
84	nucleobase catabolic process (GO:0046113)	2.73933699
85	translation (GO:0006412)	2.73141843
86	erythrocyte maturation (GO:0043249)	2.72778482
87	regulation of chronic inflammatory response (GO:0002676)	2.69586604
88	regulation of microtubule-based movement (GO:0060632)	2.67538190
89	melanocyte differentiation (GO:0030318)	2.66243044
90	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.66234180
91	regulation of mitochondrial fission (GO:0090140)	2.64635162
92	calcium ion-dependent exocytosis (GO:0017156)	2.62341503
93	positive regulation of amino acid transport (GO:0051957)	2.61976099
94	protein neddylation (GO:0045116)	2.61877194
95	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.61359587
96	erythrocyte development (GO:0048821)	2.60338278
97	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.60096696
98	anterograde axon cargo transport (GO:0008089)	2.58831301
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.58556688
100	NADH dehydrogenase complex assembly (GO:0010257)	2.58556688

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.93374548
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.62340880
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.29915397
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.88523257
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.55447441
6	VDR_22108803_ChIP-Seq_LS180_Human	3.08662831
7	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.08229327
8	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.08229327
9	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.08229327
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.48363101
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.11773322
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82472802
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.71564759
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.67290765
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.65238102
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64407378
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61690731
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.61640162
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.53285143
20	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50313615
21	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.42981107
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.40209967
23	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.38319506
24	CTCF_27219007_Chip-Seq_Bcells_Human	1.38011041
25	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35563212
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.34462110
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.33299009
28	ZNF274_21170338_ChIP-Seq_K562_Hela	1.33232631
29	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.31489750
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.30637693
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30233604
32	SA1_27219007_Chip-Seq_Bcells_Human	1.29988366
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27941434
34	TAF2_19829295_ChIP-Seq_ESCs_Human	1.26273826
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.24582625
36	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.23591791
37	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18695116
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17353531
39	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17260867
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15970759
41	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14173059
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13413673
43	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.11939225
44	BCOR_27268052_Chip-Seq_Bcells_Human	1.09892107
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09886265
46	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.09778743
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.09020839
48	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08304706
49	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.06592399
50	MYC_19829295_ChIP-Seq_ESCs_Human	1.05848617
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.05847467
52	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04559201
53	STAT1_20625510_ChIP-Seq_HELA_Human	1.04180157
54	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03290238
55	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.02825728
56	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01959884
57	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.01848554
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.00595881
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99387025
60	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98893732
61	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97072284
62	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.96727404
63	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96060232
64	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.94905218
65	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.94835032
66	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.93121282
67	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.92968489
68	XRN2_22483619_ChIP-Seq_HELA_Human	0.92576452
69	FOXP3_21729870_ChIP-Seq_TREG_Human	0.92268448
70	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92105599
71	P300_27268052_Chip-Seq_Bcells_Human	0.91621970
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90653213
73	VDR_23849224_ChIP-Seq_CD4+_Human	0.90511943
74	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90249832
75	GATA1_19941826_ChIP-Seq_K562_Human	0.88801791
76	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.88584682
77	ETV1_20927104_ChIP-Seq_GIST48_Human	0.87473472
78	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.86923376
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.86207889
80	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.86103813
81	SPI1_20517297_ChIP-Seq_HL60_Human	0.84454240
82	PHF8_20622854_ChIP-Seq_HELA_Human	0.83285243
83	ERA_21632823_ChIP-Seq_H3396_Human	0.83250744
84	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.83080456
85	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.82849648
86	P68_20966046_ChIP-Seq_HELA_Human	0.82206504
87	AR_20517297_ChIP-Seq_VCAP_Human	0.80584652
88	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.80440071
89	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.80204730
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.79096216
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.79096216
92	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.78525833
93	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.78458002
94	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.78322754
95	CTCF_20526341_ChIP-Seq_ESCs_Human	0.77961234
96	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.77848318
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.77271554
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.76487940
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.76472623
100	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.75948576

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000015_abnormal_ear_pigmentation	6.20191898
2	MP0005377_hearing/vestibular/ear_phenot	5.14559247
3	MP0003878_abnormal_ear_physiology	5.14559247
4	MP0003879_abnormal_hair_cell	4.15399800
5	MP0004145_abnormal_muscle_electrophysio	3.18820702
6	MP0004885_abnormal_endolymph	3.10495134
7	MP0001873_stomach_inflammation	2.67733713
8	MP0004742_abnormal_vestibular_system	2.65807735
9	MP0002095_abnormal_skin_pigmentation	2.32548722
10	MP0001986_abnormal_taste_sensitivity	2.21636753
11	MP0004147_increased_porphyrin_level	2.14669964
12	MP0008872_abnormal_physiological_respon	2.09847636
13	MP0002277_abnormal_respiratory_mucosa	2.02958581
14	MP0005645_abnormal_hypothalamus_physiol	2.01207100
15	MP0002138_abnormal_hepatobiliary_system	1.93713724
16	MP0006292_abnormal_olfactory_placode	1.93587788
17	MP0004133_heterotaxia	1.85677784
18	MP0008875_abnormal_xenobiotic_pharmacok	1.74879645
19	MP0004142_abnormal_muscle_tone	1.70926495
20	MP0003186_abnormal_redox_activity	1.66045526
21	MP0001485_abnormal_pinna_reflex	1.64281498
22	MP0005646_abnormal_pituitary_gland	1.61388888
23	MP0002653_abnormal_ependyma_morphology	1.59832900
24	MP0006072_abnormal_retinal_apoptosis	1.57101776
25	MP0005084_abnormal_gallbladder_morpholo	1.52090064
26	MP0003787_abnormal_imprinting	1.47963347
27	MP0001968_abnormal_touch/_nociception	1.47775775
28	MP0003303_peritoneal_inflammation	1.43735460
29	MP0005671_abnormal_response_to	1.43416222
30	MP0008877_abnormal_DNA_methylation	1.41013098
31	MP0009278_abnormal_bone_marrow	1.40866391
32	MP0000013_abnormal_adipose_tissue	1.37761650
33	MP0001440_abnormal_grooming_behavior	1.36454509
34	MP0001270_distended_abdomen	1.35917167
35	MP0000569_abnormal_digit_pigmentation	1.31593267
36	MP0003656_abnormal_erythrocyte_physiolo	1.30978933
37	MP0005075_abnormal_melanosome_morpholog	1.30897973
38	MP0009046_muscle_twitch	1.30677138
39	MP0002272_abnormal_nervous_system	1.30400811
40	MP0001919_abnormal_reproductive_system	1.29965553
41	MP0005636_abnormal_mineral_homeostasis	1.25001680
42	MP0000371_diluted_coat_color	1.24920601
43	MP0002928_abnormal_bile_duct	1.23465332
44	MP0004130_abnormal_muscle_cell	1.22149452
45	MP0005174_abnormal_tail_pigmentation	1.20494539
46	MP0003866_abnormal_defecation	1.17737462
47	MP0001663_abnormal_digestive_system	1.15148742
48	MP0003806_abnormal_nucleotide_metabolis	1.13493277
49	MP0002735_abnormal_chemical_nociception	1.10796102
50	MP0001324_abnormal_eye_pigmentation	1.09815307
51	MP0006036_abnormal_mitochondrial_physio	1.09600681
52	MP0001348_abnormal_lacrimal_gland	1.09271315
53	MP0003635_abnormal_synaptic_transmissio	1.07307080
54	MP0002177_abnormal_outer_ear	1.07020265
55	MP0003136_yellow_coat_color	1.06729326
56	MP0009745_abnormal_behavioral_response	1.05850343
57	MP0003011_delayed_dark_adaptation	1.05315943
58	MP0002102_abnormal_ear_morphology	1.00866443
59	MP0003252_abnormal_bile_duct	0.98263281
60	MP0009384_cardiac_valve_regurgitation	0.96818541
61	MP0005551_abnormal_eye_electrophysiolog	0.93047259
62	MP0005389_reproductive_system_phenotype	0.92801056
63	MP0002139_abnormal_hepatobiliary_system	0.92569806
64	MP0006035_abnormal_mitochondrial_morpho	0.90753692
65	MP0005381_digestive/alimentary_phenotyp	0.89830441
66	MP0002933_joint_inflammation	0.89728363
67	MP0002067_abnormal_sensory_capabilities	0.89290828
68	MP0001905_abnormal_dopamine_level	0.88934490
69	MP0000538_abnormal_urinary_bladder	0.86655378
70	MP0002736_abnormal_nociception_after	0.80610454
71	MP0001542_abnormal_bone_strength	0.80425214
72	MP0002876_abnormal_thyroid_physiology	0.79507546
73	MP0002557_abnormal_social/conspecific_i	0.79504940
74	MP0001293_anophthalmia	0.79093689
75	MP0002160_abnormal_reproductive_system	0.78402645
76	MP0002229_neurodegeneration	0.78064584
77	MP0003137_abnormal_impulse_conducting	0.77716728
78	MP0003938_abnormal_ear_development	0.73607490
79	MP0008775_abnormal_heart_ventricle	0.72237672
80	MP0005670_abnormal_white_adipose	0.70441161
81	MP0006082_CNS_inflammation	0.68590511
82	MP0002837_dystrophic_cardiac_calcinosis	0.68462595
83	MP0005334_abnormal_fat_pad	0.68310308
84	MP0003880_abnormal_central_pattern	0.67433237
85	MP0005085_abnormal_gallbladder_physiolo	0.65888190
86	MP0002693_abnormal_pancreas_physiology	0.64600590
87	MP0003646_muscle_fatigue	0.64471848
88	MP0004859_abnormal_synaptic_plasticity	0.64056911
89	MP0003122_maternal_imprinting	0.63614597
90	MP0001881_abnormal_mammary_gland	0.63359839
91	MP0000427_abnormal_hair_cycle	0.63353324
92	MP0000631_abnormal_neuroendocrine_gland	0.62877281
93	MP0001529_abnormal_vocalization	0.62396625
94	MP0002752_abnormal_somatic_nervous	0.61779507
95	MP0008058_abnormal_DNA_repair	0.61652945
96	MP0001800_abnormal_humoral_immune	0.61598631
97	MP0002163_abnormal_gland_morphology	0.60161485
98	MP0005000_abnormal_immune_tolerance	0.58667893
99	MP0000049_abnormal_middle_ear	0.58630232
100	MP0005253_abnormal_eye_physiology	0.56741665

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hemoglobin (HP:0011902)	7.59797737
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	6.84298150
3	Albinism (HP:0001022)	6.09850121
4	3-Methylglutaconic aciduria (HP:0003535)	4.51277953
5	Acute necrotizing encephalopathy (HP:0006965)	4.36542194
6	Pallor (HP:0000980)	4.16389749
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.86104023
8	Acute encephalopathy (HP:0006846)	3.66234708
9	Ocular albinism (HP:0001107)	3.53656190
10	Progressive macrocephaly (HP:0004481)	3.44198380
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.38054208
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.32510424
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.32510424
14	Rectal prolapse (HP:0002035)	3.29625661
15	Homocystinuria (HP:0002156)	3.22974062
16	Abnormality of homocysteine metabolism (HP:0010919)	3.22974062
17	Iris hypopigmentation (HP:0007730)	3.19061819
18	Generalized hypopigmentation (HP:0007513)	3.09839991
19	Increased CSF lactate (HP:0002490)	3.05925926
20	Abnormal number of erythroid precursors (HP:0012131)	3.03354337
21	Mitochondrial inheritance (HP:0001427)	3.01396773
22	Cerebral edema (HP:0002181)	2.89941398
23	Abnormal platelet function (HP:0011869)	2.86408115
24	Impaired platelet aggregation (HP:0003540)	2.86408115
25	Microcytic anemia (HP:0001935)	2.85359034
26	Abnormality of glycolipid metabolism (HP:0010969)	2.79834424
27	Abnormality of liposaccharide metabolism (HP:0010968)	2.79834424
28	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.79834424
29	Pancreatic cysts (HP:0001737)	2.77967512
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.70712633
31	Abnormality of alanine metabolism (HP:0010916)	2.70712633
32	Hyperalaninemia (HP:0003348)	2.70712633
33	Type II lissencephaly (HP:0007260)	2.70007561
34	Abnormal respiratory motile cilium morphology (HP:0005938)	2.69784349
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.69784349
36	Gastrointestinal infarctions (HP:0005244)	2.67597616
37	Hepatocellular necrosis (HP:0001404)	2.64971466
38	Hyperglycinemia (HP:0002154)	2.64793417
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.59101572
40	Bilateral microphthalmos (HP:0007633)	2.55074955
41	Reticulocytosis (HP:0001923)	2.54496606
42	Pancreatic fibrosis (HP:0100732)	2.47810520
43	Hypomagnesemia (HP:0002917)	2.47572352
44	Prolonged QT interval (HP:0001657)	2.46060878
45	Leukodystrophy (HP:0002415)	2.41478262
46	Myokymia (HP:0002411)	2.40162874
47	Optic disc pallor (HP:0000543)	2.33559347
48	Type 2 muscle fiber atrophy (HP:0003554)	2.31268739
49	Pendular nystagmus (HP:0012043)	2.29491130
50	Exertional dyspnea (HP:0002875)	2.24342051
51	Abnormality of reticulocytes (HP:0004312)	2.16196829
52	Retinal dysplasia (HP:0007973)	2.13260014
53	Ketosis (HP:0001946)	2.12910108
54	Increased intramyocellular lipid droplets (HP:0012240)	2.12249261
55	Abolished electroretinogram (ERG) (HP:0000550)	2.10003647
56	Lactic acidosis (HP:0003128)	2.07739740
57	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.06629604
58	Muscle fiber atrophy (HP:0100295)	2.06569376
59	Increased hepatocellular lipid droplets (HP:0006565)	2.04907139
60	Lissencephaly (HP:0001339)	2.04660641
61	Tetany (HP:0001281)	2.03456907
62	Macrocytic anemia (HP:0001972)	2.02541494
63	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01014673
64	Split foot (HP:0001839)	2.00152602
65	Increased IgM level (HP:0003496)	1.96164782
66	Abnormality of DNA repair (HP:0003254)	1.95471358
67	Hepatic necrosis (HP:0002605)	1.95201974
68	Cystic liver disease (HP:0006706)	1.95136469
69	Esophageal neoplasm (HP:0100751)	1.93996155
70	Neoplasm of head and neck (HP:0012288)	1.93996155
71	Myopathic facies (HP:0002058)	1.93804284
72	Congenital stationary night blindness (HP:0007642)	1.93130748
73	IgG deficiency (HP:0004315)	1.92738736
74	Severe muscular hypotonia (HP:0006829)	1.91992680
75	Large for gestational age (HP:0001520)	1.91953258
76	Exercise intolerance (HP:0003546)	1.89902275
77	Myotonia (HP:0002486)	1.88911358
78	Abnormality of macular pigmentation (HP:0008002)	1.88450620
79	Abnormality of magnesium homeostasis (HP:0004921)	1.88098718
80	Hypokinesia (HP:0002375)	1.87049693
81	Anencephaly (HP:0002323)	1.86598378
82	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.85458963
83	Broad distal phalanx of finger (HP:0009836)	1.83431928
84	Abnormality of the renal cortex (HP:0011035)	1.83310377
85	True hermaphroditism (HP:0010459)	1.83053885
86	Hypochromic anemia (HP:0001931)	1.82917359
87	Abnormality of midbrain morphology (HP:0002418)	1.82339824
88	Molar tooth sign on MRI (HP:0002419)	1.82339824
89	Abnormal drinking behavior (HP:0030082)	1.81863665
90	Polydipsia (HP:0001959)	1.81863665
91	Colon cancer (HP:0003003)	1.81830200
92	Increased serum lactate (HP:0002151)	1.81196959
93	Limb dystonia (HP:0002451)	1.81124964
94	Retinal atrophy (HP:0001105)	1.80293784
95	Abnormality of serum amino acid levels (HP:0003112)	1.78474616
96	Inability to walk (HP:0002540)	1.77787100
97	Absent speech (HP:0001344)	1.72005668
98	Poikilocytosis (HP:0004447)	1.71475446
99	Anophthalmia (HP:0000528)	1.71196778
100	Nasal polyposis (HP:0100582)	1.70072621

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK2	4.66484487
2	WNK3	4.19330593
3	EIF2AK1	4.10789934
4	TLK1	3.96026907
5	PINK1	3.73325216
6	CASK	3.37472411
7	TAOK3	2.70624394
8	FRK	2.38014424
9	NEK2	2.29323793
10	BCKDK	2.09978430
11	STK38	1.96956591
12	PBK	1.89739105
13	DYRK3	1.89465575
14	NTRK2	1.88001844
15	PRKD3	1.81175982
16	ABL2	1.79842333
17	STK4	1.74462503
18	WNK4	1.61814667
19	DMPK	1.61137316
20	MELK	1.56234607
21	MARK1	1.43803162
22	MAPKAPK3	1.36499783
23	GRK1	1.34693680
24	MAP4K1	1.32537789
25	JAK3	1.32178696
26	ADRBK2	1.28057126
27	RPS6KA2	1.23151093
28	TXK	1.16509315
29	TNIK	1.11281702
30	STK16	1.10082235
31	IKBKB	1.09650006
32	MAP3K11	1.07747024
33	PAK6	1.04134490
34	RPS6KA5	1.01806081
35	RPS6KA6	1.00498155
36	RPS6KC1	0.97224431
37	RPS6KL1	0.97224431
38	OXSR1	0.95345808
39	MAP2K2	0.89451388
40	DYRK2	0.86892647
41	CAMKK2	0.86830195
42	INSRR	0.85232160
43	CCNB1	0.81530215
44	NUAK1	0.78251914
45	TRPM7	0.77981734
46	PDK2	0.77221938
47	CAMKK1	0.71950784
48	CDK19	0.69424291
49	NEK1	0.69072460
50	PRKCG	0.68920414
51	CDC7	0.64935438
52	PHKG1	0.64472893
53	PHKG2	0.64472893
54	FGR	0.63668702
55	RPS6KB1	0.62927825
56	STK39	0.62488579
57	CAMK2D	0.61013500
58	MAPK4	0.60848498
59	DYRK1A	0.60449171
60	PASK	0.59397097
61	MAPK13	0.57101305
62	CHUK	0.55998247
63	ADRBK1	0.50849676
64	FES	0.50478768
65	ZAK	0.50264961
66	CDK5	0.49128026
67	PKN1	0.48104952
68	CSNK1A1	0.46261105
69	EPHA4	0.45485950
70	MKNK2	0.44451297
71	MINK1	0.43781868
72	STK11	0.43641922
73	PRKCQ	0.41832612
74	FLT3	0.41021483
75	CSNK1G3	0.40427266
76	NTRK1	0.40127624
77	MAPKAPK5	0.40085602
78	PRKACA	0.39909246
79	NME1	0.39489102
80	CSNK1G2	0.39141049
81	NTRK3	0.38111514
82	RPS6KA1	0.36365005
83	ATM	0.35498376
84	CAMK2A	0.35046964
85	ALK	0.34284347
86	CSNK1G1	0.32915152
87	MAP2K7	0.32494227
88	SRPK1	0.31785210
89	SYK	0.31750492
90	RPS6KB2	0.31648588
91	PAK3	0.31242359
92	ABL1	0.31211923
93	CAMK2G	0.30306563
94	CSNK2A1	0.30161267
95	TIE1	0.30124199
96	OBSCN	0.29821601
97	CDK14	0.29518912
98	SGK1	0.29148544
99	TYRO3	0.29134752
100	PRKDC	0.28808258

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.61199688
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.57133588
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.34441798
4	Parkinsons disease_Homo sapiens_hsa05012	2.84829715
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.81079248
6	One carbon pool by folate_Homo sapiens_hsa00670	2.35584221
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.34686040
8	Proteasome_Homo sapiens_hsa03050	2.21149339
9	Nicotine addiction_Homo sapiens_hsa05033	2.19196467
10	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.12715833
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.06788854
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.03625543
13	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.99639076
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96545536
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.85193530
16	Huntingtons disease_Homo sapiens_hsa05016	1.84689210
17	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.75729530
18	Asthma_Homo sapiens_hsa05310	1.71529612
19	Sulfur metabolism_Homo sapiens_hsa00920	1.70913739
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66928125
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.63990076
22	Basal transcription factors_Homo sapiens_hsa03022	1.63492469
23	Alzheimers disease_Homo sapiens_hsa05010	1.61338460
24	RNA polymerase_Homo sapiens_hsa03020	1.52584144
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.39204058
26	Folate biosynthesis_Homo sapiens_hsa00790	1.36515789
27	GABAergic synapse_Homo sapiens_hsa04727	1.34293518
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.31128895
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.30957864
30	Malaria_Homo sapiens_hsa05144	1.28955619
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28215453
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25600772
33	Peroxisome_Homo sapiens_hsa04146	1.19832576
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18100124
35	Caffeine metabolism_Homo sapiens_hsa00232	1.17209725
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.16284156
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15066175
38	Allograft rejection_Homo sapiens_hsa05330	1.14788827
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14123167
40	Phototransduction_Homo sapiens_hsa04744	1.11167369
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10516909
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.09656510
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.09038005
44	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07035342
45	Retinol metabolism_Homo sapiens_hsa00830	1.04508981
46	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.03748453
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02473104
48	Ether lipid metabolism_Homo sapiens_hsa00565	1.00934556
49	ABC transporters_Homo sapiens_hsa02010	0.98366343
50	Sulfur relay system_Homo sapiens_hsa04122	0.96892579
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96500886
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93145321
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.90685790
54	Morphine addiction_Homo sapiens_hsa05032	0.88809555
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.88158120
56	RNA degradation_Homo sapiens_hsa03018	0.87784492
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.86074828
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.83268445
59	Metabolic pathways_Homo sapiens_hsa01100	0.80472505
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79774725
61	Protein export_Homo sapiens_hsa03060	0.79547483
62	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.76094533
63	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71691974
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70367940
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.69239594
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68171539
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67293106
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67086576
69	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.66458259
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65642626
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.65390369
72	Taste transduction_Homo sapiens_hsa04742	0.62801500
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61177502
74	Base excision repair_Homo sapiens_hsa03410	0.57266229
75	Amphetamine addiction_Homo sapiens_hsa05031	0.54856300
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54723936
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.52458893
78	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51462661
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51035377
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48057127
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47325597
82	Insulin secretion_Homo sapiens_hsa04911	0.42600166
83	Histidine metabolism_Homo sapiens_hsa00340	0.41566439
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.40501845
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39348958
86	Olfactory transduction_Homo sapiens_hsa04740	0.38042164
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37751471
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37665499
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36916180
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36685179
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36281710
92	Propanoate metabolism_Homo sapiens_hsa00640	0.34503348
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33781722
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33780663
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.32951842
96	Serotonergic synapse_Homo sapiens_hsa04726	0.28871211
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.28549247
98	Mineral absorption_Homo sapiens_hsa04978	0.24798142
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.24105187
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.20983219

RPL14P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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