RPL15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)8.77971812
2* translational termination (GO:0006415)8.47589593
3ribosomal small subunit assembly (GO:0000028)8.24171176
4ribosomal small subunit biogenesis (GO:0042274)7.91177599
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.25890104
6* translational elongation (GO:0006414)7.24676301
7* cotranslational protein targeting to membrane (GO:0006613)7.13225074
8* protein targeting to ER (GO:0045047)7.11019518
9maturation of SSU-rRNA (GO:0030490)6.97634400
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.78794553
11* protein localization to endoplasmic reticulum (GO:0070972)6.67548982
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.63441529
13* cellular protein complex disassembly (GO:0043624)6.60468262
14* viral life cycle (GO:0019058)6.56685504
15* translational initiation (GO:0006413)6.40002683
16ribosomal large subunit biogenesis (GO:0042273)6.22545748
17* protein complex disassembly (GO:0043241)5.81725111
18* macromolecular complex disassembly (GO:0032984)5.46618944
19* nuclear-transcribed mRNA catabolic process (GO:0000956)4.84793302
20ribonucleoprotein complex biogenesis (GO:0022613)4.81535378
21* translation (GO:0006412)4.77844875
22* protein targeting to membrane (GO:0006612)4.69298236
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.68853695
24* mRNA catabolic process (GO:0006402)4.59736249
25chaperone-mediated protein transport (GO:0072321)4.51775780
26DNA deamination (GO:0045006)4.33176179
27* RNA catabolic process (GO:0006401)4.32173522
28formation of translation preinitiation complex (GO:0001731)4.23370773
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17735109
30respiratory electron transport chain (GO:0022904)4.08080428
31DNA strand elongation involved in DNA replication (GO:0006271)4.06491311
32rRNA processing (GO:0006364)4.02613785
33electron transport chain (GO:0022900)4.02063960
34telomere maintenance via semi-conservative replication (GO:0032201)3.98187686
35rRNA metabolic process (GO:0016072)3.88039611
36DNA strand elongation (GO:0022616)3.86444062
37protein complex biogenesis (GO:0070271)3.77629144
38cellular component biogenesis (GO:0044085)3.72804456
39mitochondrial respiratory chain complex assembly (GO:0033108)3.67425414
40spliceosomal snRNP assembly (GO:0000387)3.61288404
41DNA replication initiation (GO:0006270)3.59025289
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57009335
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.57009335
44NADH dehydrogenase complex assembly (GO:0010257)3.57009335
45proteasome assembly (GO:0043248)3.49421878
46DNA unwinding involved in DNA replication (GO:0006268)3.49266040
47telomere maintenance via recombination (GO:0000722)3.46600056
48regulation of mitochondrial translation (GO:0070129)3.42697051
49spliceosomal complex assembly (GO:0000245)3.39076046
50establishment of integrated proviral latency (GO:0075713)3.37899186
51protein neddylation (GO:0045116)3.35872769
52termination of RNA polymerase III transcription (GO:0006386)3.32234447
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.32234447
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29607066
55mitotic recombination (GO:0006312)3.27928255
56oxidative phosphorylation (GO:0006119)3.25117419
57DNA replication checkpoint (GO:0000076)3.22225693
58* establishment of protein localization to membrane (GO:0090150)3.17767134
59telomere maintenance via telomere lengthening (GO:0010833)3.16906130
60inner mitochondrial membrane organization (GO:0007007)3.16691640
61pseudouridine synthesis (GO:0001522)3.15817405
62cullin deneddylation (GO:0010388)3.15336917
63respiratory chain complex IV assembly (GO:0008535)3.14887661
64ribosome biogenesis (GO:0042254)3.13981331
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.12530379
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11275882
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10667163
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10667163
69ATP biosynthetic process (GO:0006754)3.08781795
70negative regulation of RNA splicing (GO:0033119)3.06841906
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05611148
72CENP-A containing nucleosome assembly (GO:0034080)3.05291640
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04461051
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03901722
75negative regulation of ligase activity (GO:0051352)3.03901722
76ncRNA 3-end processing (GO:0043628)3.03506992
77protein targeting to mitochondrion (GO:0006626)3.03048597
78* establishment of protein localization to organelle (GO:0072594)3.02839133
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02534256
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01441645
81* protein targeting (GO:0006605)3.00443629
82transcription-coupled nucleotide-excision repair (GO:0006283)3.00359571
83nucleobase biosynthetic process (GO:0046112)2.99584569
84chromatin remodeling at centromere (GO:0031055)2.99386218
85purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98362427
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97215730
87cytochrome complex assembly (GO:0017004)2.94956457
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94908265
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94136346
90regulation of helicase activity (GO:0051095)2.93543442
91protein deneddylation (GO:0000338)2.92250829
92ATP synthesis coupled proton transport (GO:0015986)2.92032023
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92032023
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90587394
95establishment of protein localization to mitochondrion (GO:0072655)2.90383114
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89302887
97ncRNA processing (GO:0034470)2.88421529
98viral mRNA export from host cell nucleus (GO:0046784)2.87158710
99ribosome assembly (GO:0042255)2.84723363
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84589658
101signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84589658
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81759192
103signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81759192
104signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81759192
105signal transduction involved in DNA damage checkpoint (GO:0072422)2.80887693
106signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80887693
107protein localization to mitochondrion (GO:0070585)2.80824191
108peptidyl-histidine modification (GO:0018202)2.79811730
109DNA replication-dependent nucleosome organization (GO:0034723)2.79644980
110DNA replication-dependent nucleosome assembly (GO:0006335)2.79644980
111DNA damage response, detection of DNA damage (GO:0042769)2.78500767
112histone mRNA metabolic process (GO:0008334)2.78135616
113ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78115868
114kinetochore organization (GO:0051383)2.77739154
115DNA replication-independent nucleosome assembly (GO:0006336)2.77579766
116DNA replication-independent nucleosome organization (GO:0034724)2.77579766
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.77068718
118protein localization to kinetochore (GO:0034501)2.76821880
119establishment of viral latency (GO:0019043)2.74918138
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74344178
121rRNA modification (GO:0000154)2.73702688
122intracellular protein transmembrane import (GO:0044743)2.73662940
123water-soluble vitamin biosynthetic process (GO:0042364)2.73414118
124RNA splicing, via transesterification reactions (GO:0000375)2.71575619
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71333941
126mRNA splicing, via spliceosome (GO:0000398)2.71333941
1277-methylguanosine mRNA capping (GO:0006370)2.70785596
128ncRNA metabolic process (GO:0034660)2.70747861
129transcription elongation from RNA polymerase I promoter (GO:0006362)2.70712671
130purine nucleobase biosynthetic process (GO:0009113)2.70446577
131hydrogen ion transmembrane transport (GO:1902600)2.70301457
132termination of RNA polymerase I transcription (GO:0006363)2.69120570
133termination of RNA polymerase II transcription (GO:0006369)2.67884013
134aldehyde catabolic process (GO:0046185)2.66371642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.59304984
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.88625063
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02122317
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.75358075
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.49306933
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.48062201
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.46879336
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42642144
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.27079529
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17642842
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07637285
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01869871
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01149397
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96827021
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96668729
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79694354
17* XRN2_22483619_ChIP-Seq_HELA_Human2.79683096
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.78579426
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67479221
20VDR_23849224_ChIP-Seq_CD4+_Human2.48342945
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48013760
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40727408
23* TTF2_22483619_ChIP-Seq_HELA_Human2.32304891
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31888325
25DCP1A_22483619_ChIP-Seq_HELA_Human2.27301955
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21927805
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20444713
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15529670
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.12811665
30ELK1_19687146_ChIP-ChIP_HELA_Human2.02900781
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01963861
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00139884
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90436122
34GABP_19822575_ChIP-Seq_HepG2_Human1.85012372
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80468277
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69058427
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65696822
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64457833
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64182241
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62601674
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62396909
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.61384523
43ZNF274_21170338_ChIP-Seq_K562_Hela1.60226150
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.56647269
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56373452
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55252564
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54157734
48CIITA_25753668_ChIP-Seq_RAJI_Human1.52599768
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52590087
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51737283
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49341274
52* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47285453
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.46105097
54* EWS_26573619_Chip-Seq_HEK293_Human1.45190359
55* FUS_26573619_Chip-Seq_HEK293_Human1.41347497
56AR_21909140_ChIP-Seq_LNCAP_Human1.41293567
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40551000
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39252546
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39227749
60* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39007914
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.38991040
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38447073
63* SOX2_16153702_ChIP-ChIP_HESCs_Human1.38286287
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.35166583
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34555534
66MYC_22102868_ChIP-Seq_BL_Human1.31179220
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30541333
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27820059
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27454619
70KDM5A_27292631_Chip-Seq_BREAST_Human1.24704062
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.23355414
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.23287321
73* MYC_18940864_ChIP-ChIP_HL60_Human1.23180694
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.20319497
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19179458
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.18589172
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18052105
78IRF1_19129219_ChIP-ChIP_H3396_Human1.17693990
79VDR_21846776_ChIP-Seq_THP-1_Human1.15607964
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15069907
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14606840
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13365076
83IGF1R_20145208_ChIP-Seq_DFB_Human1.09637280
84* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09226786
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06734962
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05456238
87VDR_22108803_ChIP-Seq_LS180_Human1.05024893
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03725023
89* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03573947
90* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03002771
91* SPI1_23547873_ChIP-Seq_NB4_Human1.02417084
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02142453
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01508223
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01428355
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99349768
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99158015
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.98551532
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97369719
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96466993
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96215386
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95374764
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95286374
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95113245
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93803669
105TFEB_21752829_ChIP-Seq_HELA_Human0.90521756
106KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89481488
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89432919
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88041437
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86549242
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85077568
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83227938
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82406890
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82051180
114TP53_22573176_ChIP-Seq_HFKS_Human0.82037624
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79692123
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79463370
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78992595
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.77759155
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77739522
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76549345
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.75743681
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.75743327
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.73557318
124FOXP1_21924763_ChIP-Seq_HESCs_Human0.71445567
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69863903
126RNF2_27304074_Chip-Seq_NSC_Mouse0.68395399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.29692342
2MP0003693_abnormal_embryo_hatching4.57164908
3MP0004957_abnormal_blastocyst_morpholog3.86777841
4MP0010094_abnormal_chromosome_stability3.50643083
5MP0003111_abnormal_nucleus_morphology3.30138817
6MP0003077_abnormal_cell_cycle3.28138580
7MP0008057_abnormal_DNA_replication2.71132764
8MP0008007_abnormal_cellular_replicative2.65122070
9MP0008932_abnormal_embryonic_tissue2.64829292
10MP0008058_abnormal_DNA_repair2.62877832
11MP0002396_abnormal_hematopoietic_system2.24439893
12MP0001529_abnormal_vocalization2.09279228
13MP0003786_premature_aging2.01850443
14MP0008995_early_reproductive_senescence1.95409898
15MP0003122_maternal_imprinting1.85841915
16MP0006072_abnormal_retinal_apoptosis1.85119418
17MP0000490_abnormal_crypts_of1.84109420
18MP0010030_abnormal_orbit_morphology1.81349741
19MP0003880_abnormal_central_pattern1.81157125
20MP0000350_abnormal_cell_proliferation1.73443799
21MP0000566_synostosis1.66962566
22MP0001730_embryonic_growth_arrest1.66122010
23MP0003787_abnormal_imprinting1.64764740
24MP0003123_paternal_imprinting1.64576753
25MP0005499_abnormal_olfactory_system1.60548585
26MP0005394_taste/olfaction_phenotype1.60548585
27MP0009333_abnormal_splenocyte_physiolog1.59890970
28MP0003315_abnormal_perineum_morphology1.59591362
29MP0000631_abnormal_neuroendocrine_gland1.54299027
30MP0003763_abnormal_thymus_physiology1.53842197
31MP0004808_abnormal_hematopoietic_stem1.48232574
32MP0003567_abnormal_fetal_cardiomyocyte1.43255090
33MP0003941_abnormal_skin_development1.43169124
34MP0005084_abnormal_gallbladder_morpholo1.42253485
35MP0002938_white_spotting1.41479420
36MP0002234_abnormal_pharynx_morphology1.40922580
37MP0009697_abnormal_copulation1.39652064
38MP0005174_abnormal_tail_pigmentation1.35759292
39MP0002736_abnormal_nociception_after1.31540008
40MP0001984_abnormal_olfaction1.30709349
41MP0001697_abnormal_embryo_size1.30452670
42MP0006035_abnormal_mitochondrial_morpho1.30396686
43MP0004142_abnormal_muscle_tone1.27494562
44MP0006036_abnormal_mitochondrial_physio1.26675939
45MP0003011_delayed_dark_adaptation1.26102109
46MP0000313_abnormal_cell_death1.26039582
47MP0002095_abnormal_skin_pigmentation1.25475064
48MP0010352_gastrointestinal_tract_polyps1.24834425
49MP0002019_abnormal_tumor_incidence1.24674372
50MP0000703_abnormal_thymus_morphology1.23908723
51MP0002080_prenatal_lethality1.22445277
52MP0006276_abnormal_autonomic_nervous1.21193138
53MP0002132_abnormal_respiratory_system1.19943446
54MP0006054_spinal_hemorrhage1.19601040
55MP0002233_abnormal_nose_morphology1.18682328
56MP0003890_abnormal_embryonic-extraembry1.18058650
57MP0006292_abnormal_olfactory_placode1.16533335
58MP0002085_abnormal_embryonic_tissue1.15560312
59MP0003718_maternal_effect1.15547810
60MP0002398_abnormal_bone_marrow1.13823549
61MP0000049_abnormal_middle_ear1.12401084
62MP0002102_abnormal_ear_morphology1.12360808
63MP0005645_abnormal_hypothalamus_physiol1.12310802
64MP0002638_abnormal_pupillary_reflex1.11352563
65MP0001293_anophthalmia1.10940079
66MP0005380_embryogenesis_phenotype1.10582692
67MP0001672_abnormal_embryogenesis/_devel1.10582692
68MP0002653_abnormal_ependyma_morphology1.10051571
69MP0002722_abnormal_immune_system1.09104596
70MP0004381_abnormal_hair_follicle1.08513912
71MP0001346_abnormal_lacrimal_gland1.07132771
72MP0005253_abnormal_eye_physiology1.06073098
73MP0009053_abnormal_anal_canal1.04898997
74MP0000537_abnormal_urethra_morphology1.04713570
75MP0002697_abnormal_eye_size1.04629293
76MP0001188_hyperpigmentation1.04408215
77MP0003136_yellow_coat_color1.04064995
78MP0003283_abnormal_digestive_organ1.03722835
79MP0005075_abnormal_melanosome_morpholog1.02809371
80MP0001545_abnormal_hematopoietic_system1.02238348
81MP0005397_hematopoietic_system_phenotyp1.02238348
82MP0002084_abnormal_developmental_patter1.01083737
83MP0005551_abnormal_eye_electrophysiolog0.99946288
84MP0000689_abnormal_spleen_morphology0.96858523
85MP0005646_abnormal_pituitary_gland0.96736118
86MP0003984_embryonic_growth_retardation0.96254009
87MP0000858_altered_metastatic_potential0.96248261
88MP0002088_abnormal_embryonic_growth/wei0.95750360
89MP0005501_abnormal_skin_physiology0.95667099
90MP0003806_abnormal_nucleotide_metabolis0.95407341
91MP0002163_abnormal_gland_morphology0.94949257
92MP0000653_abnormal_sex_gland0.94086339
93MP0000516_abnormal_urinary_system0.93367994
94MP0005367_renal/urinary_system_phenotyp0.93367994
95MP0001485_abnormal_pinna_reflex0.92435607
96MP0004197_abnormal_fetal_growth/weight/0.92025033
97MP0001929_abnormal_gametogenesis0.91895001
98MP0001905_abnormal_dopamine_level0.91370244
99MP0002429_abnormal_blood_cell0.91369161
100MP0004147_increased_porphyrin_level0.90750480
101MP0001968_abnormal_touch/_nociception0.89981836
102MP0000465_gastrointestinal_hemorrhage0.89340316
103MP0005391_vision/eye_phenotype0.88293329
104MP0001853_heart_inflammation0.87172978
105MP0000778_abnormal_nervous_system0.86698888
106MP0003186_abnormal_redox_activity0.85809407
107MP0001286_abnormal_eye_development0.85180208
108MP0002086_abnormal_extraembryonic_tissu0.84601023
109MP0002111_abnormal_tail_morphology0.81742151
110MP0002822_catalepsy0.81646497
111MP0002210_abnormal_sex_determination0.81416987
112MP0000716_abnormal_immune_system0.80798415
113MP0000685_abnormal_immune_system0.79585965
114MP0002282_abnormal_trachea_morphology0.78795081
115MP0003938_abnormal_ear_development0.77646738
116MP0004133_heterotaxia0.77306977
117MP0002752_abnormal_somatic_nervous0.76922733
118MP0001800_abnormal_humoral_immune0.76781653
119MP0003119_abnormal_digestive_system0.76759632
120MP0002557_abnormal_social/conspecific_i0.76631234
121MP0002184_abnormal_innervation0.76511063
122MP0003937_abnormal_limbs/digits/tail_de0.75772800
123MP0000372_irregular_coat_pigmentation0.75274960
124MP0003698_abnormal_male_reproductive0.75252053
125MP0008877_abnormal_DNA_methylation0.75190004
126MP0003861_abnormal_nervous_system0.74840335
127MP0005671_abnormal_response_to0.74771983
128MP0001764_abnormal_homeostasis0.74336728
129MP0001986_abnormal_taste_sensitivity0.74106019
130MP0001835_abnormal_antigen_presentation0.74027694
131MP0002420_abnormal_adaptive_immunity0.73183824
132MP0002751_abnormal_autonomic_nervous0.73041182
133MP0000358_abnormal_cell_content/0.73010770
134MP0002098_abnormal_vibrissa_morphology0.72742059
135MP0001119_abnormal_female_reproductive0.72349251
136MP0008789_abnormal_olfactory_epithelium0.71734545
137MP0001819_abnormal_immune_cell0.70983272
138MP0001145_abnormal_male_reproductive0.70728777
139MP0002166_altered_tumor_susceptibility0.70022098
140MP0002277_abnormal_respiratory_mucosa0.69221784
141MP0002932_abnormal_joint_morphology0.67721241
142MP0002249_abnormal_larynx_morphology0.67416128
143MP0002160_abnormal_reproductive_system0.67223393
144MP0000613_abnormal_salivary_gland0.65931091
145MP0002452_abnormal_antigen_presenting0.65817393
146MP0002177_abnormal_outer_ear0.65398204
147MP0002796_impaired_skin_barrier0.65026506
148MP0003121_genomic_imprinting0.64865325
149MP0002405_respiratory_system_inflammati0.64640299
150MP0009250_abnormal_appendicular_skeleto0.64460760
151MP0005409_darkened_coat_color0.64278773
152MP0005023_abnormal_wound_healing0.64185148

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.05530662
2Abnormal number of erythroid precursors (HP:0012131)7.29044206
3* Reticulocytopenia (HP:0001896)6.51084735
4* Macrocytic anemia (HP:0001972)5.48172520
5* Pallor (HP:0000980)5.03786244
6Aplasia/Hypoplasia of the sacrum (HP:0008517)3.81733490
7Aplastic anemia (HP:0001915)3.68418301
8Colon cancer (HP:0003003)3.65971429
9Thrombocytosis (HP:0001894)3.23355825
10Abnormality of the labia minora (HP:0012880)3.20918129
1111 pairs of ribs (HP:0000878)3.12635123
12Increased hepatocellular lipid droplets (HP:0006565)3.09419208
13Abnormal hemoglobin (HP:0011902)3.07199970
14Birth length less than 3rd percentile (HP:0003561)3.04345235
15Breast hypoplasia (HP:0003187)3.02939169
16Oral leukoplakia (HP:0002745)3.02105182
17Cerebral edema (HP:0002181)2.97020290
18Absent thumb (HP:0009777)2.94421452
19Mitochondrial inheritance (HP:0001427)2.91128414
20Congenital, generalized hypertrichosis (HP:0004540)2.89320307
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87743589
22Acute necrotizing encephalopathy (HP:0006965)2.84221726
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79838568
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79838568
25Hepatocellular necrosis (HP:0001404)2.79515623
26Trismus (HP:0000211)2.71801810
27Rough bone trabeculation (HP:0100670)2.69947579
28Lipid accumulation in hepatocytes (HP:0006561)2.61294795
29Exertional dyspnea (HP:0002875)2.59264527
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56152460
31Septo-optic dysplasia (HP:0100842)2.55637898
32Increased CSF lactate (HP:0002490)2.53385387
33Carpal bone hypoplasia (HP:0001498)2.52547979
34Abnormal mitochondria in muscle tissue (HP:0008316)2.49862201
35* Depressed nasal ridge (HP:0000457)2.48672980
36Multiple enchondromatosis (HP:0005701)2.48087362
37Lactic acidosis (HP:0003128)2.45961834
38Selective tooth agenesis (HP:0001592)2.44626622
39Patellar aplasia (HP:0006443)2.44267304
40Hyperglycinemia (HP:0002154)2.43316817
41Pancreatic cysts (HP:0001737)2.42686173
42Aplasia/Hypoplasia of the patella (HP:0006498)2.37605975
43Optic disc pallor (HP:0000543)2.37425120
44Methylmalonic acidemia (HP:0002912)2.37153156
45Stenosis of the external auditory canal (HP:0000402)2.31764362
46Pancreatic fibrosis (HP:0100732)2.31386595
47Hepatic necrosis (HP:0002605)2.24227116
48Horseshoe kidney (HP:0000085)2.22298244
49Medial flaring of the eyebrow (HP:0010747)2.22271143
50Increased muscle lipid content (HP:0009058)2.20151347
51Microretrognathia (HP:0000308)2.20142570
52Progressive macrocephaly (HP:0004481)2.17885385
53Cleft eyelid (HP:0000625)2.17703686
54Glossoptosis (HP:0000162)2.17587777
55Hypoplasia of the radius (HP:0002984)2.17566499
56Leukodystrophy (HP:0002415)2.16421181
57Respiratory difficulties (HP:0002880)2.15131995
58Atresia of the external auditory canal (HP:0000413)2.13977670
593-Methylglutaconic aciduria (HP:0003535)2.13570272
60Premature graying of hair (HP:0002216)2.13309879
61Increased serum lactate (HP:0002151)2.12698264
62* Triphalangeal thumb (HP:0001199)2.11728549
63True hermaphroditism (HP:0010459)2.11727729
64Molar tooth sign on MRI (HP:0002419)2.09894939
65Abnormality of midbrain morphology (HP:0002418)2.09894939
66Abnormality of the preputium (HP:0100587)2.07134238
67* Thick lower lip vermilion (HP:0000179)2.07071441
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.06982580
69Neoplasm of the pancreas (HP:0002894)2.06384481
70Meckel diverticulum (HP:0002245)2.05816886
71Type I transferrin isoform profile (HP:0003642)2.05058249
72Myelodysplasia (HP:0002863)2.04989907
73Renal Fanconi syndrome (HP:0001994)2.04062237
74Bilateral microphthalmos (HP:0007633)2.03279258
75Concave nail (HP:0001598)2.01555690
76Abnormality of methionine metabolism (HP:0010901)2.01469031
77Secondary amenorrhea (HP:0000869)2.01211504
78Cerebral hypomyelination (HP:0006808)2.00980133
79Asplenia (HP:0001746)2.00449619
80IgM deficiency (HP:0002850)1.98573623
81Abnormality of the ileum (HP:0001549)1.97328435
82Absent septum pellucidum (HP:0001331)1.96649710
83Acute encephalopathy (HP:0006846)1.96592797
84Methylmalonic aciduria (HP:0012120)1.96043589
85Lethargy (HP:0001254)1.95124747
86Woolly hair (HP:0002224)1.94748892
87Pancytopenia (HP:0001876)1.94255246
88Sparse eyelashes (HP:0000653)1.93834812
89Increased intramyocellular lipid droplets (HP:0012240)1.93402099
90Congenital primary aphakia (HP:0007707)1.93319956
91Absent radius (HP:0003974)1.93290944
92Gait imbalance (HP:0002141)1.92669546
93Abnormality of the anterior horn cell (HP:0006802)1.92455190
94Degeneration of anterior horn cells (HP:0002398)1.92455190
95Abnormal number of incisors (HP:0011064)1.91518723
96Abnormal trabecular bone morphology (HP:0100671)1.89929076
97Microvesicular hepatic steatosis (HP:0001414)1.89101044
98Exercise intolerance (HP:0003546)1.87623802
99Abnormality of renal resorption (HP:0011038)1.87574161
100Chromsome breakage (HP:0040012)1.86889662
101Missing ribs (HP:0000921)1.86320903
102Nephronophthisis (HP:0000090)1.84916229
103Anophthalmia (HP:0000528)1.84163426
104Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83747714
105Basal cell carcinoma (HP:0002671)1.83467835
106Medulloblastoma (HP:0002885)1.82443114
107Nephrogenic diabetes insipidus (HP:0009806)1.82280814
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.81837958
109Sclerocornea (HP:0000647)1.80704196
110Vaginal atresia (HP:0000148)1.78839463
111Aplasia involving forearm bones (HP:0009822)1.78419808
112Absent forearm bone (HP:0003953)1.78419808
113Premature ovarian failure (HP:0008209)1.78398814
114Myokymia (HP:0002411)1.77810422
115Abnormal lung lobation (HP:0002101)1.77196500
116Bifid tongue (HP:0010297)1.76184829
117Cellular immunodeficiency (HP:0005374)1.76059930
118Hyperglycinuria (HP:0003108)1.75947455
119Glycosuria (HP:0003076)1.75928832
120Abnormality of urine glucose concentration (HP:0011016)1.75928832
121Abnormality of the septum pellucidum (HP:0007375)1.75914438
122Genital tract atresia (HP:0001827)1.75256975
123Abnormality of chromosome stability (HP:0003220)1.74180858
124* Migraine (HP:0002076)1.72757291
125Hyperphosphaturia (HP:0003109)1.71327142
126* Abnormality of reticulocytes (HP:0004312)1.70713617
127Muscle fiber atrophy (HP:0100295)1.70694196
128Abnormality of serum amino acid levels (HP:0003112)1.70101246
129Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68644869
130Optic nerve coloboma (HP:0000588)1.68076193
131Lymphoma (HP:0002665)1.67929264
132Tracheoesophageal fistula (HP:0002575)1.67769499
133Poor suck (HP:0002033)1.67647196
134Abnormal protein glycosylation (HP:0012346)1.66856592
135Abnormal glycosylation (HP:0012345)1.66856592
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66856592
137Abnormal protein N-linked glycosylation (HP:0012347)1.66856592
138Partial duplication of the phalanx of hand (HP:0009999)1.66463938
139Respiratory failure (HP:0002878)1.66254139
140Aplasia/Hypoplasia of the thymus (HP:0010515)1.64904526
141Abnormality of glycine metabolism (HP:0010895)1.64824780
142Abnormality of serine family amino acid metabolism (HP:0010894)1.64824780
143Anencephaly (HP:0002323)1.64451070
144Bone marrow hypocellularity (HP:0005528)1.63858662
145Partial duplication of thumb phalanx (HP:0009944)1.60962961
146Preaxial hand polydactyly (HP:0001177)1.60942603
147Aplasia/hypoplasia of the uterus (HP:0008684)1.60787188
148Chromosomal breakage induced by crosslinking agents (HP:0003221)1.59318627
149Sparse lateral eyebrow (HP:0005338)1.58896294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.29006118
2NME24.63152995
3BUB14.30997905
4TLK14.17111496
5WEE13.77231686
6EIF2AK13.19647574
7SRPK12.87931963
8NUAK12.75842695
9STK162.68116886
10CDC72.51391179
11VRK12.22892358
12TAF12.22104726
13RPS6KB22.17447665
14WNK32.08603368
15TESK22.07663242
16DYRK32.03536759
17PIM21.98440662
18MAP4K21.95571747
19EIF2AK31.93635649
20TGFBR11.90263046
21MKNK11.86812123
22TRIM281.76980317
23TSSK61.74732818
24ACVR1B1.66269986
25LRRK21.63551487
26PASK1.59525434
27NEK21.51754458
28CDK71.50206248
29BRSK21.49551755
30AURKB1.48492502
31PLK41.46844590
32MAP3K121.43893565
33EEF2K1.41686965
34CDK191.40266831
35MKNK21.36152735
36PLK11.33698028
37RPS6KA41.32381488
38MST41.28225196
39KDR1.21376784
40TNIK1.17431656
41GRK11.14481825
42FLT31.12255147
43NME11.11933052
44ATR1.10522659
45AURKA1.08971129
46FGFR21.08354628
47ILK1.08114102
48MAP4K11.04126525
49TTK1.02064141
50PAK41.00552546
51CDK80.99338387
52CSNK1G10.96027269
53MAP3K80.91124861
54TEC0.90859917
55INSRR0.86626803
56NEK10.85741270
57RPS6KA50.85683360
58TESK10.85123922
59SCYL20.84781287
60BTK0.82331198
61STK100.81879010
62CSNK1G20.80870090
63PIM10.80649782
64PBK0.80228421
65DYRK20.80067788
66CSNK2A20.79956325
67PLK30.79500143
68MAP3K100.79463523
69EPHA20.79179576
70MAP3K110.77874160
71CHEK20.77274505
72ZAK0.76678650
73MAPKAPK30.76148615
74LIMK10.74671209
75CDK40.74133624
76CSNK2A10.72856363
77MAP3K40.70619334
78EIF2AK20.69270406
79BRSK10.69087049
80DAPK10.68802876
81OXSR10.68714704
82STK40.68087868
83CHEK10.67229360
84MAP2K70.65466865
85DAPK30.64303098
86EPHA40.63744410
87PAK10.63689176
88ADRBK20.62119292
89CASK0.59862265
90CSNK1A1L0.59620748
91KIT0.59452944
92CLK10.58146382
93PNCK0.57906484
94BLK0.57678007
95MUSK0.57647359
96NLK0.56944663
97ZAP700.56177989
98PRKCG0.53572710
99PRKCI0.53124363
100MAPKAPK50.51477694
101EPHB20.51246966
102ATM0.50807310
103CDK20.47763501
104PDK20.47176661
105MAPK130.46163450
106MINK10.45787679
107IKBKB0.45490294
108CSNK1E0.44705646
109BCKDK0.41700222
110CDK30.41216718
111TIE10.40902353
112ALK0.38351737
113BCR0.37675504
114MAP3K30.37566149
115GRK60.37345329
116WNK40.36422070
117BRAF0.36242382
118DYRK1B0.35975807
119IRAK40.35889025
120ABL20.34523598
121STK38L0.34366261
122PAK20.34285980
123LYN0.33962643
124MAP2K30.33836020
125CSNK1A10.33295919
126DYRK1A0.33057131
127ERBB30.32703630
128CCNB10.32184989
129STK390.31925130
130PRKDC0.31580351
131FGFR10.30639766
132BMPR1B0.29313257
133RPS6KC10.29303134
134RPS6KL10.29303134
135MAP2K20.28897817
136PKN20.28883822
137CDK10.28417133
138LCK0.28350296
139YES10.28239351
140IRAK30.28091688
141CSNK1G30.27524454
142RPS6KA60.26921197

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.91697469
2DNA replication_Homo sapiens_hsa030304.18258209
3Proteasome_Homo sapiens_hsa030503.62109987
4RNA polymerase_Homo sapiens_hsa030203.50564373
5Mismatch repair_Homo sapiens_hsa034303.49855364
6Spliceosome_Homo sapiens_hsa030403.20414372
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88367682
8Homologous recombination_Homo sapiens_hsa034402.67349135
9Nucleotide excision repair_Homo sapiens_hsa034202.58620410
10Base excision repair_Homo sapiens_hsa034102.49274445
11Pyrimidine metabolism_Homo sapiens_hsa002402.46044023
12RNA transport_Homo sapiens_hsa030132.43145054
13One carbon pool by folate_Homo sapiens_hsa006701.96346725
14Protein export_Homo sapiens_hsa030601.89800407
15Cell cycle_Homo sapiens_hsa041101.89172259
16Parkinsons disease_Homo sapiens_hsa050121.80038275
17Fanconi anemia pathway_Homo sapiens_hsa034601.77307845
18Oxidative phosphorylation_Homo sapiens_hsa001901.75351600
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68513710
20Basal transcription factors_Homo sapiens_hsa030221.67181038
21Non-homologous end-joining_Homo sapiens_hsa034501.65505500
22RNA degradation_Homo sapiens_hsa030181.60768343
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55711617
24Huntingtons disease_Homo sapiens_hsa050161.46689143
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45072732
26Propanoate metabolism_Homo sapiens_hsa006401.42853016
27Systemic lupus erythematosus_Homo sapiens_hsa053221.38464118
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34716081
29p53 signaling pathway_Homo sapiens_hsa041151.30313217
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21796751
31Purine metabolism_Homo sapiens_hsa002301.21737300
32mRNA surveillance pathway_Homo sapiens_hsa030151.20070469
33Fatty acid elongation_Homo sapiens_hsa000621.19546302
34Epstein-Barr virus infection_Homo sapiens_hsa051691.08854034
35Pyruvate metabolism_Homo sapiens_hsa006201.04402948
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03476916
37Alzheimers disease_Homo sapiens_hsa050101.02642246
38Sulfur relay system_Homo sapiens_hsa041220.99309613
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97659471
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.92645315
41Butanoate metabolism_Homo sapiens_hsa006500.90732111
42Primary immunodeficiency_Homo sapiens_hsa053400.90169771
43Antigen processing and presentation_Homo sapiens_hsa046120.86759295
44Folate biosynthesis_Homo sapiens_hsa007900.86154384
45Phototransduction_Homo sapiens_hsa047440.85104197
46Herpes simplex infection_Homo sapiens_hsa051680.83835974
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.78096790
48Viral carcinogenesis_Homo sapiens_hsa052030.75281798
49Carbon metabolism_Homo sapiens_hsa012000.75144871
50Peroxisome_Homo sapiens_hsa041460.74702211
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74308663
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73922986
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73841597
54Steroid biosynthesis_Homo sapiens_hsa001000.71509395
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69068834
56HTLV-I infection_Homo sapiens_hsa051660.61430365
57Thyroid cancer_Homo sapiens_hsa052160.60879143
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60642137
59Alcoholism_Homo sapiens_hsa050340.59588199
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58573279
61Glutathione metabolism_Homo sapiens_hsa004800.56482373
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56096680
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55581380
64Vitamin B6 metabolism_Homo sapiens_hsa007500.54761427
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53146937
66Pentose phosphate pathway_Homo sapiens_hsa000300.52997034
67Hematopoietic cell lineage_Homo sapiens_hsa046400.49932170
68Basal cell carcinoma_Homo sapiens_hsa052170.49864051
69Collecting duct acid secretion_Homo sapiens_hsa049660.49371889
70Regulation of autophagy_Homo sapiens_hsa041400.48796989
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48757920
72Legionellosis_Homo sapiens_hsa051340.44430952
73N-Glycan biosynthesis_Homo sapiens_hsa005100.43186061
74Small cell lung cancer_Homo sapiens_hsa052220.40173631
75Nicotine addiction_Homo sapiens_hsa050330.39997254
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39819990
77Measles_Homo sapiens_hsa051620.39775248
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39752926
79Oocyte meiosis_Homo sapiens_hsa041140.39612651
80Nitrogen metabolism_Homo sapiens_hsa009100.38506789
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37825862
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37438889
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.36896548
84Apoptosis_Homo sapiens_hsa042100.36855218
85Vitamin digestion and absorption_Homo sapiens_hsa049770.35864127
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35053173
87Allograft rejection_Homo sapiens_hsa053300.34734892
88MicroRNAs in cancer_Homo sapiens_hsa052060.33849703
89Arachidonic acid metabolism_Homo sapiens_hsa005900.33502863
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.33073597
91Tryptophan metabolism_Homo sapiens_hsa003800.32855647
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.32769632
93Shigellosis_Homo sapiens_hsa051310.32396130
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.31673399
95Asthma_Homo sapiens_hsa053100.31629423
96Bladder cancer_Homo sapiens_hsa052190.31219128
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30560674
98Cardiac muscle contraction_Homo sapiens_hsa042600.29998981
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28342436
100Hepatitis B_Homo sapiens_hsa051610.28321682
101Linoleic acid metabolism_Homo sapiens_hsa005910.28033976
102Metabolic pathways_Homo sapiens_hsa011000.27794595
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27713624
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27429616
105TGF-beta signaling pathway_Homo sapiens_hsa043500.27045435
106Acute myeloid leukemia_Homo sapiens_hsa052210.27044195
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26802578
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26777908
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25602050
110Chemical carcinogenesis_Homo sapiens_hsa052040.25590370
111Pathways in cancer_Homo sapiens_hsa052000.24912689
112Viral myocarditis_Homo sapiens_hsa054160.24605212
113Notch signaling pathway_Homo sapiens_hsa043300.24182996
114Hedgehog signaling pathway_Homo sapiens_hsa043400.23766035
115beta-Alanine metabolism_Homo sapiens_hsa004100.23606402
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23025684
117Hippo signaling pathway_Homo sapiens_hsa043900.22174091
118Colorectal cancer_Homo sapiens_hsa052100.22147152
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21821980
120Caffeine metabolism_Homo sapiens_hsa002320.21471376
121Tyrosine metabolism_Homo sapiens_hsa003500.21261633
122Fatty acid metabolism_Homo sapiens_hsa012120.21117744
123Biosynthesis of amino acids_Homo sapiens_hsa012300.20745532
124Olfactory transduction_Homo sapiens_hsa047400.20656911
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20562386
126Taste transduction_Homo sapiens_hsa047420.20422669
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19176668
128Sulfur metabolism_Homo sapiens_hsa009200.19089698
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.17672437
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17582892
131HIF-1 signaling pathway_Homo sapiens_hsa040660.17504967
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15248981
133Arginine and proline metabolism_Homo sapiens_hsa003300.14562652
134Renin-angiotensin system_Homo sapiens_hsa046140.14299855
135Selenocompound metabolism_Homo sapiens_hsa004500.13892747
136Ether lipid metabolism_Homo sapiens_hsa005650.13489443
137Wnt signaling pathway_Homo sapiens_hsa043100.13061775
138Autoimmune thyroid disease_Homo sapiens_hsa053200.12279645
139Fat digestion and absorption_Homo sapiens_hsa049750.12129235
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11390786
141Chronic myeloid leukemia_Homo sapiens_hsa052200.11022188
142Fatty acid degradation_Homo sapiens_hsa000710.10564353
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10476315
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10343373
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10255172

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