Rank | Gene Set | Z-score |
---|---|---|
1 | * viral transcription (GO:0019083) | 8.77971812 |
2 | * translational termination (GO:0006415) | 8.47589593 |
3 | ribosomal small subunit assembly (GO:0000028) | 8.24171176 |
4 | ribosomal small subunit biogenesis (GO:0042274) | 7.91177599 |
5 | * SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 7.25890104 |
6 | * translational elongation (GO:0006414) | 7.24676301 |
7 | * cotranslational protein targeting to membrane (GO:0006613) | 7.13225074 |
8 | * protein targeting to ER (GO:0045047) | 7.11019518 |
9 | maturation of SSU-rRNA (GO:0030490) | 6.97634400 |
10 | * establishment of protein localization to endoplasmic reticulum (GO:0072599) | 6.78794553 |
11 | * protein localization to endoplasmic reticulum (GO:0070972) | 6.67548982 |
12 | * nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 6.63441529 |
13 | * cellular protein complex disassembly (GO:0043624) | 6.60468262 |
14 | * viral life cycle (GO:0019058) | 6.56685504 |
15 | * translational initiation (GO:0006413) | 6.40002683 |
16 | ribosomal large subunit biogenesis (GO:0042273) | 6.22545748 |
17 | * protein complex disassembly (GO:0043241) | 5.81725111 |
18 | * macromolecular complex disassembly (GO:0032984) | 5.46618944 |
19 | * nuclear-transcribed mRNA catabolic process (GO:0000956) | 4.84793302 |
20 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.81535378 |
21 | * translation (GO:0006412) | 4.77844875 |
22 | * protein targeting to membrane (GO:0006612) | 4.69298236 |
23 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.68853695 |
24 | * mRNA catabolic process (GO:0006402) | 4.59736249 |
25 | chaperone-mediated protein transport (GO:0072321) | 4.51775780 |
26 | DNA deamination (GO:0045006) | 4.33176179 |
27 | * RNA catabolic process (GO:0006401) | 4.32173522 |
28 | formation of translation preinitiation complex (GO:0001731) | 4.23370773 |
29 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.17735109 |
30 | respiratory electron transport chain (GO:0022904) | 4.08080428 |
31 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.06491311 |
32 | rRNA processing (GO:0006364) | 4.02613785 |
33 | electron transport chain (GO:0022900) | 4.02063960 |
34 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.98187686 |
35 | rRNA metabolic process (GO:0016072) | 3.88039611 |
36 | DNA strand elongation (GO:0022616) | 3.86444062 |
37 | protein complex biogenesis (GO:0070271) | 3.77629144 |
38 | cellular component biogenesis (GO:0044085) | 3.72804456 |
39 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.67425414 |
40 | spliceosomal snRNP assembly (GO:0000387) | 3.61288404 |
41 | DNA replication initiation (GO:0006270) | 3.59025289 |
42 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.57009335 |
43 | NADH dehydrogenase complex assembly (GO:0010257) | 3.57009335 |
44 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.57009335 |
45 | proteasome assembly (GO:0043248) | 3.49421878 |
46 | DNA unwinding involved in DNA replication (GO:0006268) | 3.49266040 |
47 | telomere maintenance via recombination (GO:0000722) | 3.46600056 |
48 | regulation of mitochondrial translation (GO:0070129) | 3.42697051 |
49 | spliceosomal complex assembly (GO:0000245) | 3.39076046 |
50 | establishment of integrated proviral latency (GO:0075713) | 3.37899186 |
51 | protein neddylation (GO:0045116) | 3.35872769 |
52 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.32234447 |
53 | termination of RNA polymerase III transcription (GO:0006386) | 3.32234447 |
54 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.29607066 |
55 | mitotic recombination (GO:0006312) | 3.27928255 |
56 | oxidative phosphorylation (GO:0006119) | 3.25117419 |
57 | DNA replication checkpoint (GO:0000076) | 3.22225693 |
58 | * establishment of protein localization to membrane (GO:0090150) | 3.17767134 |
59 | telomere maintenance via telomere lengthening (GO:0010833) | 3.16906130 |
60 | inner mitochondrial membrane organization (GO:0007007) | 3.16691640 |
61 | pseudouridine synthesis (GO:0001522) | 3.15817405 |
62 | cullin deneddylation (GO:0010388) | 3.15336917 |
63 | respiratory chain complex IV assembly (GO:0008535) | 3.14887661 |
64 | ribosome biogenesis (GO:0042254) | 3.13981331 |
65 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.12530379 |
66 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.11275882 |
67 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.10667163 |
68 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.10667163 |
69 | ATP biosynthetic process (GO:0006754) | 3.08781795 |
70 | negative regulation of RNA splicing (GO:0033119) | 3.06841906 |
71 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.05611148 |
72 | CENP-A containing nucleosome assembly (GO:0034080) | 3.05291640 |
73 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.04461051 |
74 | negative regulation of ligase activity (GO:0051352) | 3.03901722 |
75 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.03901722 |
76 | ncRNA 3-end processing (GO:0043628) | 3.03506992 |
77 | protein targeting to mitochondrion (GO:0006626) | 3.03048597 |
78 | * establishment of protein localization to organelle (GO:0072594) | 3.02839133 |
79 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.02534256 |
80 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.01441645 |
81 | * protein targeting (GO:0006605) | 3.00443629 |
82 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.00359571 |
83 | nucleobase biosynthetic process (GO:0046112) | 2.99584569 |
84 | chromatin remodeling at centromere (GO:0031055) | 2.99386218 |
85 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.98362427 |
86 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.97215730 |
87 | cytochrome complex assembly (GO:0017004) | 2.94956457 |
88 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.94908265 |
89 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.94136346 |
90 | regulation of helicase activity (GO:0051095) | 2.93543442 |
91 | protein deneddylation (GO:0000338) | 2.92250829 |
92 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.92032023 |
93 | ATP synthesis coupled proton transport (GO:0015986) | 2.92032023 |
94 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.90587394 |
95 | establishment of protein localization to mitochondrion (GO:0072655) | 2.90383114 |
96 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.89302887 |
97 | ncRNA processing (GO:0034470) | 2.88421529 |
98 | viral mRNA export from host cell nucleus (GO:0046784) | 2.87158710 |
99 | ribosome assembly (GO:0042255) | 2.84723363 |
100 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.84589658 |
101 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.84589658 |
102 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.81759192 |
103 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.81759192 |
104 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.81759192 |
105 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.80887693 |
106 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.80887693 |
107 | protein localization to mitochondrion (GO:0070585) | 2.80824191 |
108 | peptidyl-histidine modification (GO:0018202) | 2.79811730 |
109 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.79644980 |
110 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.79644980 |
111 | DNA damage response, detection of DNA damage (GO:0042769) | 2.78500767 |
112 | histone mRNA metabolic process (GO:0008334) | 2.78135616 |
113 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.78115868 |
114 | kinetochore organization (GO:0051383) | 2.77739154 |
115 | DNA replication-independent nucleosome organization (GO:0034724) | 2.77579766 |
116 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.77579766 |
117 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.77068718 |
118 | protein localization to kinetochore (GO:0034501) | 2.76821880 |
119 | establishment of viral latency (GO:0019043) | 2.74918138 |
120 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.74344178 |
121 | rRNA modification (GO:0000154) | 2.73702688 |
122 | intracellular protein transmembrane import (GO:0044743) | 2.73662940 |
123 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.73414118 |
124 | RNA splicing, via transesterification reactions (GO:0000375) | 2.71575619 |
125 | mRNA splicing, via spliceosome (GO:0000398) | 2.71333941 |
126 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.71333941 |
127 | 7-methylguanosine mRNA capping (GO:0006370) | 2.70785596 |
128 | ncRNA metabolic process (GO:0034660) | 2.70747861 |
129 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.70712671 |
130 | purine nucleobase biosynthetic process (GO:0009113) | 2.70446577 |
131 | hydrogen ion transmembrane transport (GO:1902600) | 2.70301457 |
132 | termination of RNA polymerase I transcription (GO:0006363) | 2.69120570 |
133 | termination of RNA polymerase II transcription (GO:0006369) | 2.67884013 |
134 | aldehyde catabolic process (GO:0046185) | 2.66371642 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.59304984 |
2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.88625063 |
3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.02122317 |
4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.75358075 |
5 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.49306933 |
6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.48062201 |
7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.46879336 |
8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.42642144 |
9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.27079529 |
10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.17642842 |
11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.07637285 |
12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.01869871 |
13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.01149397 |
14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.96827021 |
15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.96668729 |
16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.79694354 |
17 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.79683096 |
18 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.78579426 |
19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.67479221 |
20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.48342945 |
21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.48013760 |
22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.40727408 |
23 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.32304891 |
24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.31888325 |
25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.27301955 |
26 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.21927805 |
27 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.20444713 |
28 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.15529670 |
29 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12811665 |
30 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.02900781 |
31 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.01963861 |
32 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.00139884 |
33 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.90436122 |
34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.85012372 |
35 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.80468277 |
36 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.69058427 |
37 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.65696822 |
38 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.64457833 |
39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.64182241 |
40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.62601674 |
41 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.62396909 |
42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.61384523 |
43 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.60226150 |
44 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.56647269 |
45 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.56373452 |
46 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.55252564 |
47 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.54157734 |
48 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.52599768 |
49 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.52590087 |
50 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.51737283 |
51 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.49341274 |
52 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.47285453 |
53 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.46105097 |
54 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.45190359 |
55 | * FUS_26573619_Chip-Seq_HEK293_Human | 1.41347497 |
56 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.41293567 |
57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.40551000 |
58 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.39252546 |
59 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.39227749 |
60 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.39007914 |
61 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.38991040 |
62 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.38447073 |
63 | * SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.38286287 |
64 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.35166583 |
65 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34555534 |
66 | MYC_22102868_ChIP-Seq_BL_Human | 1.31179220 |
67 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.30541333 |
68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27820059 |
69 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.27454619 |
70 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.24704062 |
71 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.23355414 |
72 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.23287321 |
73 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.23180694 |
74 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.20319497 |
75 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.19179458 |
76 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.18589172 |
77 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.18052105 |
78 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.17693990 |
79 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.15607964 |
80 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.15069907 |
81 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.14606840 |
82 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.13365076 |
83 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.09637280 |
84 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.09226786 |
85 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.06734962 |
86 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.05456238 |
87 | VDR_22108803_ChIP-Seq_LS180_Human | 1.05024893 |
88 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.03725023 |
89 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.03573947 |
90 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.03002771 |
91 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.02417084 |
92 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.02142453 |
93 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.01508223 |
94 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.01428355 |
95 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.99349768 |
96 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.99158015 |
97 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.98551532 |
98 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.97369719 |
99 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96466993 |
100 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.96215386 |
101 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.95374764 |
102 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.95286374 |
103 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.95113245 |
104 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.93803669 |
105 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.90521756 |
106 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.89481488 |
107 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.89432919 |
108 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.88041437 |
109 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.86549242 |
110 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.85077568 |
111 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.83227938 |
112 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.82406890 |
113 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.82051180 |
114 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.82037624 |
115 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.79692123 |
116 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.79463370 |
117 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.78992595 |
118 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.77759155 |
119 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.77739522 |
120 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.76549345 |
121 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.75743681 |
122 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.75743327 |
123 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.73557318 |
124 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.71445567 |
125 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.69863903 |
126 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.68395399 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 5.29692342 |
2 | MP0003693_abnormal_embryo_hatching | 4.57164908 |
3 | MP0004957_abnormal_blastocyst_morpholog | 3.86777841 |
4 | MP0010094_abnormal_chromosome_stability | 3.50643083 |
5 | MP0003111_abnormal_nucleus_morphology | 3.30138817 |
6 | MP0003077_abnormal_cell_cycle | 3.28138580 |
7 | MP0008057_abnormal_DNA_replication | 2.71132764 |
8 | MP0008007_abnormal_cellular_replicative | 2.65122070 |
9 | MP0008932_abnormal_embryonic_tissue | 2.64829292 |
10 | MP0008058_abnormal_DNA_repair | 2.62877832 |
11 | MP0002396_abnormal_hematopoietic_system | 2.24439893 |
12 | MP0001529_abnormal_vocalization | 2.09279228 |
13 | MP0003786_premature_aging | 2.01850443 |
14 | MP0008995_early_reproductive_senescence | 1.95409898 |
15 | MP0003122_maternal_imprinting | 1.85841915 |
16 | MP0006072_abnormal_retinal_apoptosis | 1.85119418 |
17 | MP0000490_abnormal_crypts_of | 1.84109420 |
18 | MP0010030_abnormal_orbit_morphology | 1.81349741 |
19 | MP0003880_abnormal_central_pattern | 1.81157125 |
20 | MP0000350_abnormal_cell_proliferation | 1.73443799 |
21 | MP0000566_synostosis | 1.66962566 |
22 | MP0001730_embryonic_growth_arrest | 1.66122010 |
23 | MP0003787_abnormal_imprinting | 1.64764740 |
24 | MP0003123_paternal_imprinting | 1.64576753 |
25 | MP0005394_taste/olfaction_phenotype | 1.60548585 |
26 | MP0005499_abnormal_olfactory_system | 1.60548585 |
27 | MP0009333_abnormal_splenocyte_physiolog | 1.59890970 |
28 | MP0003315_abnormal_perineum_morphology | 1.59591362 |
29 | MP0000631_abnormal_neuroendocrine_gland | 1.54299027 |
30 | MP0003763_abnormal_thymus_physiology | 1.53842197 |
31 | MP0004808_abnormal_hematopoietic_stem | 1.48232574 |
32 | MP0003567_abnormal_fetal_cardiomyocyte | 1.43255090 |
33 | MP0003941_abnormal_skin_development | 1.43169124 |
34 | MP0005084_abnormal_gallbladder_morpholo | 1.42253485 |
35 | MP0002938_white_spotting | 1.41479420 |
36 | MP0002234_abnormal_pharynx_morphology | 1.40922580 |
37 | MP0009697_abnormal_copulation | 1.39652064 |
38 | MP0005174_abnormal_tail_pigmentation | 1.35759292 |
39 | MP0002736_abnormal_nociception_after | 1.31540008 |
40 | MP0001984_abnormal_olfaction | 1.30709349 |
41 | MP0001697_abnormal_embryo_size | 1.30452670 |
42 | MP0006035_abnormal_mitochondrial_morpho | 1.30396686 |
43 | MP0004142_abnormal_muscle_tone | 1.27494562 |
44 | MP0006036_abnormal_mitochondrial_physio | 1.26675939 |
45 | MP0003011_delayed_dark_adaptation | 1.26102109 |
46 | MP0000313_abnormal_cell_death | 1.26039582 |
47 | MP0002095_abnormal_skin_pigmentation | 1.25475064 |
48 | MP0010352_gastrointestinal_tract_polyps | 1.24834425 |
49 | MP0002019_abnormal_tumor_incidence | 1.24674372 |
50 | MP0000703_abnormal_thymus_morphology | 1.23908723 |
51 | MP0002080_prenatal_lethality | 1.22445277 |
52 | MP0006276_abnormal_autonomic_nervous | 1.21193138 |
53 | MP0002132_abnormal_respiratory_system | 1.19943446 |
54 | MP0006054_spinal_hemorrhage | 1.19601040 |
55 | MP0002233_abnormal_nose_morphology | 1.18682328 |
56 | MP0003890_abnormal_embryonic-extraembry | 1.18058650 |
57 | MP0006292_abnormal_olfactory_placode | 1.16533335 |
58 | MP0002085_abnormal_embryonic_tissue | 1.15560312 |
59 | MP0003718_maternal_effect | 1.15547810 |
60 | MP0002398_abnormal_bone_marrow | 1.13823549 |
61 | MP0000049_abnormal_middle_ear | 1.12401084 |
62 | MP0002102_abnormal_ear_morphology | 1.12360808 |
63 | MP0005645_abnormal_hypothalamus_physiol | 1.12310802 |
64 | MP0002638_abnormal_pupillary_reflex | 1.11352563 |
65 | MP0001293_anophthalmia | 1.10940079 |
66 | MP0001672_abnormal_embryogenesis/_devel | 1.10582692 |
67 | MP0005380_embryogenesis_phenotype | 1.10582692 |
68 | MP0002653_abnormal_ependyma_morphology | 1.10051571 |
69 | MP0002722_abnormal_immune_system | 1.09104596 |
70 | MP0004381_abnormal_hair_follicle | 1.08513912 |
71 | MP0001346_abnormal_lacrimal_gland | 1.07132771 |
72 | MP0005253_abnormal_eye_physiology | 1.06073098 |
73 | MP0009053_abnormal_anal_canal | 1.04898997 |
74 | MP0000537_abnormal_urethra_morphology | 1.04713570 |
75 | MP0002697_abnormal_eye_size | 1.04629293 |
76 | MP0001188_hyperpigmentation | 1.04408215 |
77 | MP0003136_yellow_coat_color | 1.04064995 |
78 | MP0003283_abnormal_digestive_organ | 1.03722835 |
79 | MP0005075_abnormal_melanosome_morpholog | 1.02809371 |
80 | MP0001545_abnormal_hematopoietic_system | 1.02238348 |
81 | MP0005397_hematopoietic_system_phenotyp | 1.02238348 |
82 | MP0002084_abnormal_developmental_patter | 1.01083737 |
83 | MP0005551_abnormal_eye_electrophysiolog | 0.99946288 |
84 | MP0000689_abnormal_spleen_morphology | 0.96858523 |
85 | MP0005646_abnormal_pituitary_gland | 0.96736118 |
86 | MP0003984_embryonic_growth_retardation | 0.96254009 |
87 | MP0000858_altered_metastatic_potential | 0.96248261 |
88 | MP0002088_abnormal_embryonic_growth/wei | 0.95750360 |
89 | MP0005501_abnormal_skin_physiology | 0.95667099 |
90 | MP0003806_abnormal_nucleotide_metabolis | 0.95407341 |
91 | MP0002163_abnormal_gland_morphology | 0.94949257 |
92 | MP0000653_abnormal_sex_gland | 0.94086339 |
93 | MP0005367_renal/urinary_system_phenotyp | 0.93367994 |
94 | MP0000516_abnormal_urinary_system | 0.93367994 |
95 | MP0001485_abnormal_pinna_reflex | 0.92435607 |
96 | MP0004197_abnormal_fetal_growth/weight/ | 0.92025033 |
97 | MP0001929_abnormal_gametogenesis | 0.91895001 |
98 | MP0001905_abnormal_dopamine_level | 0.91370244 |
99 | MP0002429_abnormal_blood_cell | 0.91369161 |
100 | MP0004147_increased_porphyrin_level | 0.90750480 |
101 | MP0001968_abnormal_touch/_nociception | 0.89981836 |
102 | MP0000465_gastrointestinal_hemorrhage | 0.89340316 |
103 | MP0005391_vision/eye_phenotype | 0.88293329 |
104 | MP0001853_heart_inflammation | 0.87172978 |
105 | MP0000778_abnormal_nervous_system | 0.86698888 |
106 | MP0003186_abnormal_redox_activity | 0.85809407 |
107 | MP0001286_abnormal_eye_development | 0.85180208 |
108 | MP0002086_abnormal_extraembryonic_tissu | 0.84601023 |
109 | MP0002111_abnormal_tail_morphology | 0.81742151 |
110 | MP0002822_catalepsy | 0.81646497 |
111 | MP0002210_abnormal_sex_determination | 0.81416987 |
112 | MP0000716_abnormal_immune_system | 0.80798415 |
113 | MP0000685_abnormal_immune_system | 0.79585965 |
114 | MP0002282_abnormal_trachea_morphology | 0.78795081 |
115 | MP0003938_abnormal_ear_development | 0.77646738 |
116 | MP0004133_heterotaxia | 0.77306977 |
117 | MP0002752_abnormal_somatic_nervous | 0.76922733 |
118 | MP0001800_abnormal_humoral_immune | 0.76781653 |
119 | MP0003119_abnormal_digestive_system | 0.76759632 |
120 | MP0002557_abnormal_social/conspecific_i | 0.76631234 |
121 | MP0002184_abnormal_innervation | 0.76511063 |
122 | MP0003937_abnormal_limbs/digits/tail_de | 0.75772800 |
123 | MP0000372_irregular_coat_pigmentation | 0.75274960 |
124 | MP0003698_abnormal_male_reproductive | 0.75252053 |
125 | MP0008877_abnormal_DNA_methylation | 0.75190004 |
126 | MP0003861_abnormal_nervous_system | 0.74840335 |
127 | MP0005671_abnormal_response_to | 0.74771983 |
128 | MP0001764_abnormal_homeostasis | 0.74336728 |
129 | MP0001986_abnormal_taste_sensitivity | 0.74106019 |
130 | MP0001835_abnormal_antigen_presentation | 0.74027694 |
131 | MP0002420_abnormal_adaptive_immunity | 0.73183824 |
132 | MP0002751_abnormal_autonomic_nervous | 0.73041182 |
133 | MP0000358_abnormal_cell_content/ | 0.73010770 |
134 | MP0002098_abnormal_vibrissa_morphology | 0.72742059 |
135 | MP0001119_abnormal_female_reproductive | 0.72349251 |
136 | MP0008789_abnormal_olfactory_epithelium | 0.71734545 |
137 | MP0001819_abnormal_immune_cell | 0.70983272 |
138 | MP0001145_abnormal_male_reproductive | 0.70728777 |
139 | MP0002166_altered_tumor_susceptibility | 0.70022098 |
140 | MP0002277_abnormal_respiratory_mucosa | 0.69221784 |
141 | MP0002932_abnormal_joint_morphology | 0.67721241 |
142 | MP0002249_abnormal_larynx_morphology | 0.67416128 |
143 | MP0002160_abnormal_reproductive_system | 0.67223393 |
144 | MP0000613_abnormal_salivary_gland | 0.65931091 |
145 | MP0002452_abnormal_antigen_presenting | 0.65817393 |
146 | MP0002177_abnormal_outer_ear | 0.65398204 |
147 | MP0002796_impaired_skin_barrier | 0.65026506 |
148 | MP0003121_genomic_imprinting | 0.64865325 |
149 | MP0002405_respiratory_system_inflammati | 0.64640299 |
150 | MP0009250_abnormal_appendicular_skeleto | 0.64460760 |
151 | MP0005409_darkened_coat_color | 0.64278773 |
152 | MP0005023_abnormal_wound_healing | 0.64185148 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 8.05530662 |
2 | Abnormal number of erythroid precursors (HP:0012131) | 7.29044206 |
3 | * Reticulocytopenia (HP:0001896) | 6.51084735 |
4 | * Macrocytic anemia (HP:0001972) | 5.48172520 |
5 | * Pallor (HP:0000980) | 5.03786244 |
6 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.81733490 |
7 | Aplastic anemia (HP:0001915) | 3.68418301 |
8 | Colon cancer (HP:0003003) | 3.65971429 |
9 | Thrombocytosis (HP:0001894) | 3.23355825 |
10 | Abnormality of the labia minora (HP:0012880) | 3.20918129 |
11 | 11 pairs of ribs (HP:0000878) | 3.12635123 |
12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.09419208 |
13 | Abnormal hemoglobin (HP:0011902) | 3.07199970 |
14 | Birth length less than 3rd percentile (HP:0003561) | 3.04345235 |
15 | Breast hypoplasia (HP:0003187) | 3.02939169 |
16 | Oral leukoplakia (HP:0002745) | 3.02105182 |
17 | Cerebral edema (HP:0002181) | 2.97020290 |
18 | Absent thumb (HP:0009777) | 2.94421452 |
19 | Mitochondrial inheritance (HP:0001427) | 2.91128414 |
20 | Congenital, generalized hypertrichosis (HP:0004540) | 2.89320307 |
21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.87743589 |
22 | Acute necrotizing encephalopathy (HP:0006965) | 2.84221726 |
23 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.79838568 |
24 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.79838568 |
25 | Hepatocellular necrosis (HP:0001404) | 2.79515623 |
26 | Trismus (HP:0000211) | 2.71801810 |
27 | Rough bone trabeculation (HP:0100670) | 2.69947579 |
28 | Lipid accumulation in hepatocytes (HP:0006561) | 2.61294795 |
29 | Exertional dyspnea (HP:0002875) | 2.59264527 |
30 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.56152460 |
31 | Septo-optic dysplasia (HP:0100842) | 2.55637898 |
32 | Increased CSF lactate (HP:0002490) | 2.53385387 |
33 | Carpal bone hypoplasia (HP:0001498) | 2.52547979 |
34 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.49862201 |
35 | * Depressed nasal ridge (HP:0000457) | 2.48672980 |
36 | Multiple enchondromatosis (HP:0005701) | 2.48087362 |
37 | Lactic acidosis (HP:0003128) | 2.45961834 |
38 | Selective tooth agenesis (HP:0001592) | 2.44626622 |
39 | Patellar aplasia (HP:0006443) | 2.44267304 |
40 | Hyperglycinemia (HP:0002154) | 2.43316817 |
41 | Pancreatic cysts (HP:0001737) | 2.42686173 |
42 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.37605975 |
43 | Optic disc pallor (HP:0000543) | 2.37425120 |
44 | Methylmalonic acidemia (HP:0002912) | 2.37153156 |
45 | Stenosis of the external auditory canal (HP:0000402) | 2.31764362 |
46 | Pancreatic fibrosis (HP:0100732) | 2.31386595 |
47 | Hepatic necrosis (HP:0002605) | 2.24227116 |
48 | Horseshoe kidney (HP:0000085) | 2.22298244 |
49 | Medial flaring of the eyebrow (HP:0010747) | 2.22271143 |
50 | Increased muscle lipid content (HP:0009058) | 2.20151347 |
51 | Microretrognathia (HP:0000308) | 2.20142570 |
52 | Progressive macrocephaly (HP:0004481) | 2.17885385 |
53 | Cleft eyelid (HP:0000625) | 2.17703686 |
54 | Glossoptosis (HP:0000162) | 2.17587777 |
55 | Hypoplasia of the radius (HP:0002984) | 2.17566499 |
56 | Leukodystrophy (HP:0002415) | 2.16421181 |
57 | Respiratory difficulties (HP:0002880) | 2.15131995 |
58 | Atresia of the external auditory canal (HP:0000413) | 2.13977670 |
59 | 3-Methylglutaconic aciduria (HP:0003535) | 2.13570272 |
60 | Premature graying of hair (HP:0002216) | 2.13309879 |
61 | Increased serum lactate (HP:0002151) | 2.12698264 |
62 | * Triphalangeal thumb (HP:0001199) | 2.11728549 |
63 | True hermaphroditism (HP:0010459) | 2.11727729 |
64 | Molar tooth sign on MRI (HP:0002419) | 2.09894939 |
65 | Abnormality of midbrain morphology (HP:0002418) | 2.09894939 |
66 | Abnormality of the preputium (HP:0100587) | 2.07134238 |
67 | * Thick lower lip vermilion (HP:0000179) | 2.07071441 |
68 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.06982580 |
69 | Neoplasm of the pancreas (HP:0002894) | 2.06384481 |
70 | Meckel diverticulum (HP:0002245) | 2.05816886 |
71 | Type I transferrin isoform profile (HP:0003642) | 2.05058249 |
72 | Myelodysplasia (HP:0002863) | 2.04989907 |
73 | Renal Fanconi syndrome (HP:0001994) | 2.04062237 |
74 | Bilateral microphthalmos (HP:0007633) | 2.03279258 |
75 | Concave nail (HP:0001598) | 2.01555690 |
76 | Abnormality of methionine metabolism (HP:0010901) | 2.01469031 |
77 | Secondary amenorrhea (HP:0000869) | 2.01211504 |
78 | Cerebral hypomyelination (HP:0006808) | 2.00980133 |
79 | Asplenia (HP:0001746) | 2.00449619 |
80 | IgM deficiency (HP:0002850) | 1.98573623 |
81 | Abnormality of the ileum (HP:0001549) | 1.97328435 |
82 | Absent septum pellucidum (HP:0001331) | 1.96649710 |
83 | Acute encephalopathy (HP:0006846) | 1.96592797 |
84 | Methylmalonic aciduria (HP:0012120) | 1.96043589 |
85 | Lethargy (HP:0001254) | 1.95124747 |
86 | Woolly hair (HP:0002224) | 1.94748892 |
87 | Pancytopenia (HP:0001876) | 1.94255246 |
88 | Sparse eyelashes (HP:0000653) | 1.93834812 |
89 | Increased intramyocellular lipid droplets (HP:0012240) | 1.93402099 |
90 | Congenital primary aphakia (HP:0007707) | 1.93319956 |
91 | Absent radius (HP:0003974) | 1.93290944 |
92 | Gait imbalance (HP:0002141) | 1.92669546 |
93 | Degeneration of anterior horn cells (HP:0002398) | 1.92455190 |
94 | Abnormality of the anterior horn cell (HP:0006802) | 1.92455190 |
95 | Abnormal number of incisors (HP:0011064) | 1.91518723 |
96 | Abnormal trabecular bone morphology (HP:0100671) | 1.89929076 |
97 | Microvesicular hepatic steatosis (HP:0001414) | 1.89101044 |
98 | Exercise intolerance (HP:0003546) | 1.87623802 |
99 | Abnormality of renal resorption (HP:0011038) | 1.87574161 |
100 | Chromsome breakage (HP:0040012) | 1.86889662 |
101 | Missing ribs (HP:0000921) | 1.86320903 |
102 | Nephronophthisis (HP:0000090) | 1.84916229 |
103 | Anophthalmia (HP:0000528) | 1.84163426 |
104 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.83747714 |
105 | Basal cell carcinoma (HP:0002671) | 1.83467835 |
106 | Medulloblastoma (HP:0002885) | 1.82443114 |
107 | Nephrogenic diabetes insipidus (HP:0009806) | 1.82280814 |
108 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.81837958 |
109 | Sclerocornea (HP:0000647) | 1.80704196 |
110 | Vaginal atresia (HP:0000148) | 1.78839463 |
111 | Aplasia involving forearm bones (HP:0009822) | 1.78419808 |
112 | Absent forearm bone (HP:0003953) | 1.78419808 |
113 | Premature ovarian failure (HP:0008209) | 1.78398814 |
114 | Myokymia (HP:0002411) | 1.77810422 |
115 | Abnormal lung lobation (HP:0002101) | 1.77196500 |
116 | Bifid tongue (HP:0010297) | 1.76184829 |
117 | Cellular immunodeficiency (HP:0005374) | 1.76059930 |
118 | Hyperglycinuria (HP:0003108) | 1.75947455 |
119 | Abnormality of urine glucose concentration (HP:0011016) | 1.75928832 |
120 | Glycosuria (HP:0003076) | 1.75928832 |
121 | Abnormality of the septum pellucidum (HP:0007375) | 1.75914438 |
122 | Genital tract atresia (HP:0001827) | 1.75256975 |
123 | Abnormality of chromosome stability (HP:0003220) | 1.74180858 |
124 | * Migraine (HP:0002076) | 1.72757291 |
125 | Hyperphosphaturia (HP:0003109) | 1.71327142 |
126 | * Abnormality of reticulocytes (HP:0004312) | 1.70713617 |
127 | Muscle fiber atrophy (HP:0100295) | 1.70694196 |
128 | Abnormality of serum amino acid levels (HP:0003112) | 1.70101246 |
129 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.68644869 |
130 | Optic nerve coloboma (HP:0000588) | 1.68076193 |
131 | Lymphoma (HP:0002665) | 1.67929264 |
132 | Tracheoesophageal fistula (HP:0002575) | 1.67769499 |
133 | Poor suck (HP:0002033) | 1.67647196 |
134 | Abnormal protein glycosylation (HP:0012346) | 1.66856592 |
135 | Abnormal glycosylation (HP:0012345) | 1.66856592 |
136 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.66856592 |
137 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.66856592 |
138 | Partial duplication of the phalanx of hand (HP:0009999) | 1.66463938 |
139 | Respiratory failure (HP:0002878) | 1.66254139 |
140 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.64904526 |
141 | Abnormality of glycine metabolism (HP:0010895) | 1.64824780 |
142 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.64824780 |
143 | Anencephaly (HP:0002323) | 1.64451070 |
144 | Bone marrow hypocellularity (HP:0005528) | 1.63858662 |
145 | Partial duplication of thumb phalanx (HP:0009944) | 1.60962961 |
146 | Preaxial hand polydactyly (HP:0001177) | 1.60942603 |
147 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.60787188 |
148 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.59318627 |
149 | Sparse lateral eyebrow (HP:0005338) | 1.58896294 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 5.29006118 |
2 | NME2 | 4.63152995 |
3 | BUB1 | 4.30997905 |
4 | TLK1 | 4.17111496 |
5 | WEE1 | 3.77231686 |
6 | EIF2AK1 | 3.19647574 |
7 | SRPK1 | 2.87931963 |
8 | NUAK1 | 2.75842695 |
9 | STK16 | 2.68116886 |
10 | CDC7 | 2.51391179 |
11 | VRK1 | 2.22892358 |
12 | TAF1 | 2.22104726 |
13 | RPS6KB2 | 2.17447665 |
14 | WNK3 | 2.08603368 |
15 | TESK2 | 2.07663242 |
16 | DYRK3 | 2.03536759 |
17 | PIM2 | 1.98440662 |
18 | MAP4K2 | 1.95571747 |
19 | EIF2AK3 | 1.93635649 |
20 | TGFBR1 | 1.90263046 |
21 | MKNK1 | 1.86812123 |
22 | TRIM28 | 1.76980317 |
23 | TSSK6 | 1.74732818 |
24 | ACVR1B | 1.66269986 |
25 | LRRK2 | 1.63551487 |
26 | PASK | 1.59525434 |
27 | NEK2 | 1.51754458 |
28 | CDK7 | 1.50206248 |
29 | BRSK2 | 1.49551755 |
30 | AURKB | 1.48492502 |
31 | PLK4 | 1.46844590 |
32 | MAP3K12 | 1.43893565 |
33 | EEF2K | 1.41686965 |
34 | CDK19 | 1.40266831 |
35 | MKNK2 | 1.36152735 |
36 | PLK1 | 1.33698028 |
37 | RPS6KA4 | 1.32381488 |
38 | MST4 | 1.28225196 |
39 | KDR | 1.21376784 |
40 | TNIK | 1.17431656 |
41 | GRK1 | 1.14481825 |
42 | FLT3 | 1.12255147 |
43 | NME1 | 1.11933052 |
44 | ATR | 1.10522659 |
45 | AURKA | 1.08971129 |
46 | FGFR2 | 1.08354628 |
47 | ILK | 1.08114102 |
48 | MAP4K1 | 1.04126525 |
49 | TTK | 1.02064141 |
50 | PAK4 | 1.00552546 |
51 | CDK8 | 0.99338387 |
52 | CSNK1G1 | 0.96027269 |
53 | MAP3K8 | 0.91124861 |
54 | TEC | 0.90859917 |
55 | INSRR | 0.86626803 |
56 | NEK1 | 0.85741270 |
57 | RPS6KA5 | 0.85683360 |
58 | TESK1 | 0.85123922 |
59 | SCYL2 | 0.84781287 |
60 | BTK | 0.82331198 |
61 | STK10 | 0.81879010 |
62 | CSNK1G2 | 0.80870090 |
63 | PIM1 | 0.80649782 |
64 | PBK | 0.80228421 |
65 | DYRK2 | 0.80067788 |
66 | CSNK2A2 | 0.79956325 |
67 | PLK3 | 0.79500143 |
68 | MAP3K10 | 0.79463523 |
69 | EPHA2 | 0.79179576 |
70 | MAP3K11 | 0.77874160 |
71 | CHEK2 | 0.77274505 |
72 | ZAK | 0.76678650 |
73 | MAPKAPK3 | 0.76148615 |
74 | LIMK1 | 0.74671209 |
75 | CDK4 | 0.74133624 |
76 | CSNK2A1 | 0.72856363 |
77 | MAP3K4 | 0.70619334 |
78 | EIF2AK2 | 0.69270406 |
79 | BRSK1 | 0.69087049 |
80 | DAPK1 | 0.68802876 |
81 | OXSR1 | 0.68714704 |
82 | STK4 | 0.68087868 |
83 | CHEK1 | 0.67229360 |
84 | MAP2K7 | 0.65466865 |
85 | DAPK3 | 0.64303098 |
86 | EPHA4 | 0.63744410 |
87 | PAK1 | 0.63689176 |
88 | ADRBK2 | 0.62119292 |
89 | CASK | 0.59862265 |
90 | CSNK1A1L | 0.59620748 |
91 | KIT | 0.59452944 |
92 | CLK1 | 0.58146382 |
93 | PNCK | 0.57906484 |
94 | BLK | 0.57678007 |
95 | MUSK | 0.57647359 |
96 | NLK | 0.56944663 |
97 | ZAP70 | 0.56177989 |
98 | PRKCG | 0.53572710 |
99 | PRKCI | 0.53124363 |
100 | MAPKAPK5 | 0.51477694 |
101 | EPHB2 | 0.51246966 |
102 | ATM | 0.50807310 |
103 | CDK2 | 0.47763501 |
104 | PDK2 | 0.47176661 |
105 | MAPK13 | 0.46163450 |
106 | MINK1 | 0.45787679 |
107 | IKBKB | 0.45490294 |
108 | CSNK1E | 0.44705646 |
109 | BCKDK | 0.41700222 |
110 | CDK3 | 0.41216718 |
111 | TIE1 | 0.40902353 |
112 | ALK | 0.38351737 |
113 | BCR | 0.37675504 |
114 | MAP3K3 | 0.37566149 |
115 | GRK6 | 0.37345329 |
116 | WNK4 | 0.36422070 |
117 | BRAF | 0.36242382 |
118 | DYRK1B | 0.35975807 |
119 | IRAK4 | 0.35889025 |
120 | ABL2 | 0.34523598 |
121 | STK38L | 0.34366261 |
122 | PAK2 | 0.34285980 |
123 | LYN | 0.33962643 |
124 | MAP2K3 | 0.33836020 |
125 | CSNK1A1 | 0.33295919 |
126 | DYRK1A | 0.33057131 |
127 | ERBB3 | 0.32703630 |
128 | CCNB1 | 0.32184989 |
129 | STK39 | 0.31925130 |
130 | PRKDC | 0.31580351 |
131 | FGFR1 | 0.30639766 |
132 | BMPR1B | 0.29313257 |
133 | RPS6KC1 | 0.29303134 |
134 | RPS6KL1 | 0.29303134 |
135 | MAP2K2 | 0.28897817 |
136 | PKN2 | 0.28883822 |
137 | CDK1 | 0.28417133 |
138 | LCK | 0.28350296 |
139 | YES1 | 0.28239351 |
140 | IRAK3 | 0.28091688 |
141 | CSNK1G3 | 0.27524454 |
142 | RPS6KA6 | 0.26921197 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Ribosome_Homo sapiens_hsa03010 | 6.91697469 |
2 | DNA replication_Homo sapiens_hsa03030 | 4.18258209 |
3 | Proteasome_Homo sapiens_hsa03050 | 3.62109987 |
4 | RNA polymerase_Homo sapiens_hsa03020 | 3.50564373 |
5 | Mismatch repair_Homo sapiens_hsa03430 | 3.49855364 |
6 | Spliceosome_Homo sapiens_hsa03040 | 3.20414372 |
7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.88367682 |
8 | Homologous recombination_Homo sapiens_hsa03440 | 2.67349135 |
9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.58620410 |
10 | Base excision repair_Homo sapiens_hsa03410 | 2.49274445 |
11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.46044023 |
12 | RNA transport_Homo sapiens_hsa03013 | 2.43145054 |
13 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.96346725 |
14 | Protein export_Homo sapiens_hsa03060 | 1.89800407 |
15 | Cell cycle_Homo sapiens_hsa04110 | 1.89172259 |
16 | Parkinsons disease_Homo sapiens_hsa05012 | 1.80038275 |
17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.77307845 |
18 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.75351600 |
19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.68513710 |
20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.67181038 |
21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.65505500 |
22 | RNA degradation_Homo sapiens_hsa03018 | 1.60768343 |
23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.55711617 |
24 | Huntingtons disease_Homo sapiens_hsa05016 | 1.46689143 |
25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.45072732 |
26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.42853016 |
27 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.38464118 |
28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.34716081 |
29 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.30313217 |
30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.21796751 |
31 | Purine metabolism_Homo sapiens_hsa00230 | 1.21737300 |
32 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.20070469 |
33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.19546302 |
34 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.08854034 |
35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.04402948 |
36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.03476916 |
37 | Alzheimers disease_Homo sapiens_hsa05010 | 1.02642246 |
38 | Sulfur relay system_Homo sapiens_hsa04122 | 0.99309613 |
39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.97659471 |
40 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.92645315 |
41 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.90732111 |
42 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.90169771 |
43 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.86759295 |
44 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.86154384 |
45 | Phototransduction_Homo sapiens_hsa04744 | 0.85104197 |
46 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.83835974 |
47 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.78096790 |
48 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.75281798 |
49 | Carbon metabolism_Homo sapiens_hsa01200 | 0.75144871 |
50 | Peroxisome_Homo sapiens_hsa04146 | 0.74702211 |
51 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.74308663 |
52 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.73922986 |
53 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.73841597 |
54 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.71509395 |
55 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.69068834 |
56 | HTLV-I infection_Homo sapiens_hsa05166 | 0.61430365 |
57 | Thyroid cancer_Homo sapiens_hsa05216 | 0.60879143 |
58 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.60642137 |
59 | Alcoholism_Homo sapiens_hsa05034 | 0.59588199 |
60 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.58573279 |
61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56482373 |
62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.56096680 |
63 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.55581380 |
64 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.54761427 |
65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.53146937 |
66 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.52997034 |
67 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.49932170 |
68 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.49864051 |
69 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.49371889 |
70 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.48796989 |
71 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.48757920 |
72 | Legionellosis_Homo sapiens_hsa05134 | 0.44430952 |
73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43186061 |
74 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.40173631 |
75 | Nicotine addiction_Homo sapiens_hsa05033 | 0.39997254 |
76 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.39819990 |
77 | Measles_Homo sapiens_hsa05162 | 0.39775248 |
78 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.39752926 |
79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.39612651 |
80 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.38506789 |
81 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.37825862 |
82 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.37438889 |
83 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.36896548 |
84 | Apoptosis_Homo sapiens_hsa04210 | 0.36855218 |
85 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.35864127 |
86 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.35053173 |
87 | Allograft rejection_Homo sapiens_hsa05330 | 0.34734892 |
88 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.33849703 |
89 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.33502863 |
90 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.33073597 |
91 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.32855647 |
92 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.32769632 |
93 | Shigellosis_Homo sapiens_hsa05131 | 0.32396130 |
94 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.31673399 |
95 | Asthma_Homo sapiens_hsa05310 | 0.31629423 |
96 | Bladder cancer_Homo sapiens_hsa05219 | 0.31219128 |
97 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.30560674 |
98 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.29998981 |
99 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.28342436 |
100 | Hepatitis B_Homo sapiens_hsa05161 | 0.28321682 |
101 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.28033976 |
102 | Metabolic pathways_Homo sapiens_hsa01100 | 0.27794595 |
103 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27713624 |
104 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.27429616 |
105 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.27045435 |
106 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.27044195 |
107 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.26802578 |
108 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.26777908 |
109 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.25602050 |
110 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.25590370 |
111 | Pathways in cancer_Homo sapiens_hsa05200 | 0.24912689 |
112 | Viral myocarditis_Homo sapiens_hsa05416 | 0.24605212 |
113 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.24182996 |
114 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.23766035 |
115 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.23606402 |
116 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.23025684 |
117 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.22174091 |
118 | Colorectal cancer_Homo sapiens_hsa05210 | 0.22147152 |
119 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.21821980 |
120 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.21471376 |
121 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.21261633 |
122 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.21117744 |
123 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.20745532 |
124 | Olfactory transduction_Homo sapiens_hsa04740 | 0.20656911 |
125 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.20562386 |
126 | Taste transduction_Homo sapiens_hsa04742 | 0.20422669 |
127 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.19176668 |
128 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.19089698 |
129 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.17672437 |
130 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.17582892 |
131 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.17504967 |
132 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.15248981 |
133 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.14562652 |
134 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.14299855 |
135 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.13892747 |
136 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.13489443 |
137 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.13061775 |
138 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.12279645 |
139 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.12129235 |
140 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.11390786 |
141 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.11022188 |
142 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.10564353 |
143 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.10476315 |
144 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.10343373 |
145 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.10255172 |