RPL15P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.57823200
2tolerance induction (GO:0002507)5.77921939
3positive regulation of prostaglandin secretion (GO:0032308)5.01398568
4viral transcription (GO:0019083)4.96789739
5translational termination (GO:0006415)4.72586159
6behavioral response to nicotine (GO:0035095)4.68722094
7regulation of gamma-delta T cell differentiation (GO:0045586)4.40978026
8translational elongation (GO:0006414)4.32590374
9protein neddylation (GO:0045116)4.23869913
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22898733
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.22607780
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.22607780
13NADH dehydrogenase complex assembly (GO:0010257)4.22607780
14ribosomal small subunit assembly (GO:0000028)4.21102073
15ncRNA 3-end processing (GO:0043628)4.17493580
16positive regulation of gamma-delta T cell activation (GO:0046645)4.17307713
17DNA replication checkpoint (GO:0000076)4.14185998
18positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.08018114
19DNA deamination (GO:0045006)4.03846515
20positive regulation of fatty acid transport (GO:2000193)4.00865999
21regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.00313002
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96719798
23protein complex biogenesis (GO:0070271)3.96051601
24regulation of prostaglandin secretion (GO:0032306)3.96013655
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.91631295
26protein targeting to ER (GO:0045047)3.90962164
27positive regulation of uterine smooth muscle contraction (GO:0070474)3.88172200
28ATP synthesis coupled proton transport (GO:0015986)3.87161529
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87161529
30cotranslational protein targeting to membrane (GO:0006613)3.85827870
31viral life cycle (GO:0019058)3.84478765
32lysosome localization (GO:0032418)3.82331761
33cellular protein complex disassembly (GO:0043624)3.78687242
34mitochondrial respiratory chain complex assembly (GO:0033108)3.75924335
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73532896
36protein localization to endoplasmic reticulum (GO:0070972)3.72908344
37positive regulation of icosanoid secretion (GO:0032305)3.71607507
38ribosomal large subunit biogenesis (GO:0042273)3.69010283
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59982608
40regulation of gamma-delta T cell activation (GO:0046643)3.58041589
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44492455
42cellular component biogenesis (GO:0044085)3.42546744
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42230700
44anterograde synaptic vesicle transport (GO:0048490)3.35742542
45ribonucleoprotein complex biogenesis (GO:0022613)3.35283578
46organelle membrane fusion (GO:0090174)3.31843360
47phosphatidylinositol acyl-chain remodeling (GO:0036149)3.21785094
48L-fucose catabolic process (GO:0042355)3.17573351
49fucose catabolic process (GO:0019317)3.17573351
50L-fucose metabolic process (GO:0042354)3.17573351
51translational initiation (GO:0006413)3.16538914
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16129313
53positive regulation of defense response to virus by host (GO:0002230)3.15426357
54fucosylation (GO:0036065)3.15223141
55zinc ion homeostasis (GO:0055069)3.15099507
56phosphatidylserine acyl-chain remodeling (GO:0036150)3.11417597
57regulation of T cell receptor signaling pathway (GO:0050856)3.11358584
58protein complex disassembly (GO:0043241)3.03961405
59water-soluble vitamin biosynthetic process (GO:0042364)3.01486837
60regulation of uterine smooth muscle contraction (GO:0070472)2.99701968
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98259975
62negative regulation of mast cell activation (GO:0033004)2.96841923
63regulation of glucocorticoid secretion (GO:2000849)2.96754772
64maturation of 5.8S rRNA (GO:0000460)2.96553853
65translation (GO:0006412)2.94553134
66electron transport chain (GO:0022900)2.87231172
67base-excision repair, AP site formation (GO:0006285)2.86716365
68negative regulation of T cell differentiation in thymus (GO:0033085)2.80924456
69intra-S DNA damage checkpoint (GO:0031573)2.80803076
70macromolecular complex disassembly (GO:0032984)2.79211155
71phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77773425
72preassembly of GPI anchor in ER membrane (GO:0016254)2.76693355
73respiratory electron transport chain (GO:0022904)2.76410087
74viral protein processing (GO:0019082)2.73506046
75negative regulation of phagocytosis (GO:0050765)2.70943455
76respiratory chain complex IV assembly (GO:0008535)2.70792045
77cellular zinc ion homeostasis (GO:0006882)2.69231871
78GTP biosynthetic process (GO:0006183)2.67606677
79detection of mechanical stimulus involved in sensory perception (GO:0050974)2.67556487
80RNA destabilization (GO:0050779)2.67427438
81regulation of regulatory T cell differentiation (GO:0045589)2.66956791
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66108600
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66108600
84regulation of interleukin-12 biosynthetic process (GO:0045075)2.63234180
85actin filament depolymerization (GO:0030042)2.61647857
86regulation of icosanoid secretion (GO:0032303)2.58664573
87cellular response to interferon-beta (GO:0035458)2.54430848
88inositol phosphate dephosphorylation (GO:0046855)2.52308852
89phosphorylated carbohydrate dephosphorylation (GO:0046838)2.52308852
90purine-containing compound salvage (GO:0043101)2.52089053
91negative regulation of B cell apoptotic process (GO:0002903)2.49806134
92positive regulation of smooth muscle contraction (GO:0045987)2.49412191
93regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.47765282
94multicellular organism reproduction (GO:0032504)2.47707007
95cellular response to dsRNA (GO:0071359)2.46147195
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.45451731
97purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44435997
98purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.44405950
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.44227896
100cell proliferation in forebrain (GO:0021846)2.44154543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.93949848
2ZNF274_21170338_ChIP-Seq_K562_Hela3.44130235
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.38280738
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.79249131
5ETS1_20019798_ChIP-Seq_JURKAT_Human2.76044033
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67414079
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59062512
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42941236
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.42240310
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42015903
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34003710
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12908165
13EZH2_22144423_ChIP-Seq_EOC_Human2.01657275
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00083706
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.93204121
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90788624
17IRF1_19129219_ChIP-ChIP_H3396_Human1.90548612
18VDR_23849224_ChIP-Seq_CD4+_Human1.90548088
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83532096
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.79181753
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77951044
22FOXP3_21729870_ChIP-Seq_TREG_Human1.76231966
23VDR_22108803_ChIP-Seq_LS180_Human1.75223116
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71219777
25FOXA1_27270436_Chip-Seq_PROSTATE_Human1.70275265
26FOXA1_25329375_ChIP-Seq_VCAP_Human1.70275265
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.70039607
28TP53_22573176_ChIP-Seq_HFKS_Human1.66950381
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62599122
30STAT1_20625510_ChIP-Seq_HELA_Human1.61703127
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58541356
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57635305
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56944601
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56513752
35NANOG_20526341_ChIP-Seq_ESCs_Human1.55755738
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53357498
37TAF2_19829295_ChIP-Seq_ESCs_Human1.53316045
38BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51534096
39ERA_21632823_ChIP-Seq_H3396_Human1.51109188
40MYC_18940864_ChIP-ChIP_HL60_Human1.46967578
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44600720
42ELK1_19687146_ChIP-ChIP_HELA_Human1.39721653
43NCOR_22424771_ChIP-Seq_293T_Human1.34226863
44AR_20517297_ChIP-Seq_VCAP_Human1.33191717
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32769669
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.30869526
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28247308
48XRN2_22483619_ChIP-Seq_HELA_Human1.27992208
49GATA3_26560356_Chip-Seq_TH2_Human1.22983560
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18695041
51EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18009381
52FOXH1_21741376_ChIP-Seq_ESCs_Human1.17796238
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17661663
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17504125
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16483806
56BCL6_27268052_Chip-Seq_Bcells_Human1.16304377
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16149852
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15502895
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14335689
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.13582220
61CTCF_20526341_ChIP-Seq_ESCs_Human1.13480987
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13136103
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.12495235
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11268665
65ER_23166858_ChIP-Seq_MCF-7_Human1.10268373
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09980232
67E2F1_20622854_ChIP-Seq_HELA_Human1.07567552
68FUS_26573619_Chip-Seq_HEK293_Human1.07565403
69RUNX_20019798_ChIP-Seq_JUKART_Human1.07526010
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06845825
71GABP_19822575_ChIP-Seq_HepG2_Human1.04502885
72SA1_27219007_Chip-Seq_Bcells_Human1.04139183
73SOX2_19829295_ChIP-Seq_ESCs_Human1.04118862
74NANOG_19829295_ChIP-Seq_ESCs_Human1.04118862
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.04032666
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03921179
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03219687
78ERG_20517297_ChIP-Seq_VCAP_Human1.02826431
79GATA3_27048872_Chip-Seq_THYMUS_Human1.01854359
80SOX2_21211035_ChIP-Seq_LN229_Human1.01299387
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99708698
82P300_27268052_Chip-Seq_Bcells_Human0.99182301
83REST_21632747_ChIP-Seq_MESCs_Mouse0.97454747
84HOXB7_26014856_ChIP-Seq_BT474_Human0.95810487
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94970829
86EWS_26573619_Chip-Seq_HEK293_Human0.94930143
87RAC3_21632823_ChIP-Seq_H3396_Human0.94678563
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93553504
89FLI1_21867929_ChIP-Seq_CD8_Mouse0.93410389
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93341177
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93123162
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93075263
93STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92834010
94P53_21459846_ChIP-Seq_SAOS-2_Human0.92358499
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91267089
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90622804
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.89901206
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.89612441
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89342455
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.89241340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005075_abnormal_melanosome_morpholog5.03375284
2MP0000569_abnormal_digit_pigmentation3.49043644
3MP0002102_abnormal_ear_morphology3.35214287
4MP0005174_abnormal_tail_pigmentation3.03976308
5MP0003646_muscle_fatigue2.67546077
6MP0005408_hypopigmentation2.55474275
7MP0006082_CNS_inflammation2.52978479
8MP0001968_abnormal_touch/_nociception2.48391144
9MP0000371_diluted_coat_color2.47749647
10MP0002163_abnormal_gland_morphology2.45430886
11MP0002653_abnormal_ependyma_morphology2.41823580
12MP0001873_stomach_inflammation2.35018229
13MP0005671_abnormal_response_to2.34389219
14MP0006292_abnormal_olfactory_placode2.17849357
15MP0000566_synostosis2.06874960
16MP0008875_abnormal_xenobiotic_pharmacok2.06555650
17MP0009379_abnormal_foot_pigmentation2.02391839
18MP0009333_abnormal_splenocyte_physiolog2.01512571
19MP0002638_abnormal_pupillary_reflex1.98410987
20MP0000015_abnormal_ear_pigmentation1.96827844
21MP0002837_dystrophic_cardiac_calcinosis1.94888731
22MP0005646_abnormal_pituitary_gland1.94522420
23MP0002095_abnormal_skin_pigmentation1.93678497
24MP0003879_abnormal_hair_cell1.79681687
25MP0004510_myositis1.77325663
26MP0001800_abnormal_humoral_immune1.75988143
27MP0003763_abnormal_thymus_physiology1.64833640
28MP0003195_calcinosis1.61712148
29MP0008872_abnormal_physiological_respon1.61651559
30MP0003011_delayed_dark_adaptation1.55235254
31MP0001919_abnormal_reproductive_system1.52600779
32MP0001835_abnormal_antigen_presentation1.44449338
33MP0005389_reproductive_system_phenotype1.37587181
34MP0005551_abnormal_eye_electrophysiolog1.34769575
35MP0002938_white_spotting1.33631765
36MP0004145_abnormal_muscle_electrophysio1.32253456
37MP0005379_endocrine/exocrine_gland_phen1.31617604
38MP0001905_abnormal_dopamine_level1.31039473
39MP0002075_abnormal_coat/hair_pigmentati1.30364967
40MP0000372_irregular_coat_pigmentation1.30220359
41MP0002909_abnormal_adrenal_gland1.28601602
42MP0008877_abnormal_DNA_methylation1.28302492
43MP0005645_abnormal_hypothalamus_physiol1.22205148
44MP0003638_abnormal_response/metabolism_1.20321032
45MP0002723_abnormal_immune_serum1.20146558
46MP0005387_immune_system_phenotype1.16758216
47MP0001790_abnormal_immune_system1.16758216
48MP0002876_abnormal_thyroid_physiology1.16311288
49MP0002148_abnormal_hypersensitivity_rea1.15610982
50MP0002138_abnormal_hepatobiliary_system1.15395655
51MP0003136_yellow_coat_color1.14905505
52MP0002452_abnormal_antigen_presenting1.14172575
53MP0009764_decreased_sensitivity_to1.11826739
54MP0008007_abnormal_cellular_replicative1.10756646
55MP0004484_altered_response_of1.05408855
56MP0001986_abnormal_taste_sensitivity1.03508776
57MP0002420_abnormal_adaptive_immunity1.03129547
58MP0001819_abnormal_immune_cell1.02724434
59MP0004885_abnormal_endolymph1.02672810
60MP0002736_abnormal_nociception_after1.02521643
61MP0006072_abnormal_retinal_apoptosis0.98588786
62MP0009745_abnormal_behavioral_response0.94030803
63MP0001663_abnormal_digestive_system0.93631964
64MP0009785_altered_susceptibility_to0.91432072
65MP0006036_abnormal_mitochondrial_physio0.90197683
66MP0005084_abnormal_gallbladder_morpholo0.88427777
67MP0005000_abnormal_immune_tolerance0.88305512
68MP0004142_abnormal_muscle_tone0.86640024
69MP0002277_abnormal_respiratory_mucosa0.85653142
70MP0003878_abnormal_ear_physiology0.85472824
71MP0005377_hearing/vestibular/ear_phenot0.85472824
72MP0001186_pigmentation_phenotype0.84179942
73MP0005083_abnormal_biliary_tract0.83741247
74MP0004043_abnormal_pH_regulation0.83452889
75MP0002160_abnormal_reproductive_system0.82365764
76MP0009780_abnormal_chondrocyte_physiolo0.81818438
77MP0008775_abnormal_heart_ventricle0.81612472
78MP0002933_joint_inflammation0.80130984
79MP0005025_abnormal_response_to0.79351716
80MP0000049_abnormal_middle_ear0.79284713
81MP0005167_abnormal_blood-brain_barrier0.76815054
82MP0000703_abnormal_thymus_morphology0.76134220
83MP0004130_abnormal_muscle_cell0.75908409
84MP0000716_abnormal_immune_system0.75359493
85MP0003786_premature_aging0.74768706
86MP0008469_abnormal_protein_level0.71658476
87MP0001845_abnormal_inflammatory_respons0.70423614
88MP0002398_abnormal_bone_marrow0.69649992
89MP0005410_abnormal_fertilization0.67938624
90MP0005464_abnormal_platelet_physiology0.67913244
91MP0009046_muscle_twitch0.67656101
92MP0003121_genomic_imprinting0.66998542
93MP0003866_abnormal_defecation0.66548083
94MP0003183_abnormal_peptide_metabolism0.66442047
95MP0008789_abnormal_olfactory_epithelium0.66435542
96MP0002722_abnormal_immune_system0.66394390
97MP0000685_abnormal_immune_system0.65667217
98MP0005253_abnormal_eye_physiology0.65129136
99MP0002557_abnormal_social/conspecific_i0.64862091
100MP0000343_altered_response_to0.64784527

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.54486151
2Abnormality of B cell number (HP:0010975)5.16998343
3IgM deficiency (HP:0002850)4.97462899
4IgG deficiency (HP:0004315)4.33735553
5Congenital stationary night blindness (HP:0007642)3.90688341
6Abnormal mitochondria in muscle tissue (HP:0008316)3.76953695
7Attenuation of retinal blood vessels (HP:0007843)3.69900651
8Abnormal rod and cone electroretinograms (HP:0008323)3.68255209
9Constricted visual fields (HP:0001133)3.43774127
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.43291839
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39909392
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39909392
13Mitochondrial inheritance (HP:0001427)3.39682412
14Acute necrotizing encephalopathy (HP:0006965)3.31250127
15Elevated erythrocyte sedimentation rate (HP:0003565)3.29679786
16Increased intramyocellular lipid droplets (HP:0012240)3.27888860
17Hepatocellular necrosis (HP:0001404)3.24495127
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.18294361
19Abnormality of alanine metabolism (HP:0010916)3.18294361
20Hyperalaninemia (HP:0003348)3.18294361
21Severe visual impairment (HP:0001141)3.15338549
22Increased CSF lactate (HP:0002490)3.14077836
23Abnormality of macular pigmentation (HP:0008002)3.12385988
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.10664122
25Oligodactyly (hands) (HP:0001180)2.96547934
26Humeroradial synostosis (HP:0003041)2.93401803
27Synostosis involving the elbow (HP:0003938)2.93401803
28Increased muscle lipid content (HP:0009058)2.92082352
29Adactyly (HP:0009776)2.80163291
30Progressive macrocephaly (HP:0004481)2.73384504
31Hepatic necrosis (HP:0002605)2.71682125
32Acute encephalopathy (HP:0006846)2.70280825
33Type II lissencephaly (HP:0007260)2.69675392
34Stomatitis (HP:0010280)2.68962402
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.67934624
36Striae distensae (HP:0001065)2.61971398
373-Methylglutaconic aciduria (HP:0003535)2.61254905
38Abnormality of T cell physiology (HP:0011840)2.59528814
39Recurrent sinusitis (HP:0011108)2.59204517
40Pendular nystagmus (HP:0012043)2.56083095
41Recurrent bronchitis (HP:0002837)2.55738270
42Abnormality of the costochondral junction (HP:0000919)2.54148647
43Optic disc pallor (HP:0000543)2.53606464
44Type 2 muscle fiber atrophy (HP:0003554)2.51947075
45Aplasia/hypoplasia of the uterus (HP:0008684)2.51827588
46Albinism (HP:0001022)2.48383458
47Hypoglycemic seizures (HP:0002173)2.46222688
48Pancreatic cysts (HP:0001737)2.41653563
49Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.41010152
50IgA deficiency (HP:0002720)2.36299523
51Fibular aplasia (HP:0002990)2.31032279
52Congenital, generalized hypertrichosis (HP:0004540)2.30102698
53Lipid accumulation in hepatocytes (HP:0006561)2.29736841
54Abnormal drinking behavior (HP:0030082)2.28938749
55Polydipsia (HP:0001959)2.28938749
56Abnormal biliary tract physiology (HP:0012439)2.28714482
57Bile duct proliferation (HP:0001408)2.28714482
58Femoral bowing (HP:0002980)2.27218408
59Esophageal neoplasm (HP:0100751)2.27033877
60Neoplasm of head and neck (HP:0012288)2.27033877
61Decreased central vision (HP:0007663)2.24814258
62Round ear (HP:0100830)2.24517868
63Nephronophthisis (HP:0000090)2.23360113
64Muscle fiber atrophy (HP:0100295)2.18949007
65Posterior subcapsular cataract (HP:0007787)2.18139604
66Symphalangism affecting the phalanges of the hand (HP:0009773)2.17197416
67Increased hepatocellular lipid droplets (HP:0006565)2.16654002
68Abnormality of midbrain morphology (HP:0002418)2.11557351
69Molar tooth sign on MRI (HP:0002419)2.11557351
70Pancreatic fibrosis (HP:0100732)2.09128064
71Lactic acidosis (HP:0003128)2.05454783
72Abolished electroretinogram (ERG) (HP:0000550)2.04790693
73Increased serum lactate (HP:0002151)2.01809711
74Volvulus (HP:0002580)2.01267776
75Oligodactyly (HP:0012165)1.98580587
76Abnormality of the pons (HP:0007361)1.98228214
77Cerebral edema (HP:0002181)1.96001864
78Severe combined immunodeficiency (HP:0004430)1.94540247
79Abnormality of T cells (HP:0002843)1.92973448
80Split foot (HP:0001839)1.92641077
81Renal Fanconi syndrome (HP:0001994)1.92479506
82Cupped ribs (HP:0000887)1.92256933
83Increased corneal curvature (HP:0100692)1.91890910
84Keratoconus (HP:0000563)1.91890910
85Gastrointestinal stroma tumor (HP:0100723)1.90849661
86Abnormality of the nasal septum (HP:0000419)1.89042149
87True hermaphroditism (HP:0010459)1.87746020
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.86264950
89Absent/shortened dynein arms (HP:0200106)1.86264950
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.85197179
91Hypoplasia of the fovea (HP:0007750)1.85197179
92Radial bowing (HP:0002986)1.85104865
93Hypoplasia of the pons (HP:0012110)1.80657202
94Cone-rod dystrophy (HP:0000548)1.80298217
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78558397
96Thyroiditis (HP:0100646)1.78448186
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77641707
98Carpal bone hypoplasia (HP:0001498)1.77264005
99Asplenia (HP:0001746)1.76251335
100Decreased muscle mass (HP:0003199)1.74181101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.72558182
2ADRBK23.68541919
3TLK13.44175401
4TXK3.35579383
5TEC3.14144929
6GRK12.64728847
7TIE12.43350203
8MAP4K12.40069676
9WNK42.34724180
10ARAF2.25037582
11BCKDK2.21954173
12ZAK2.20131634
13FES2.15994683
14MAP3K91.95033827
15CSK1.94848297
16SYK1.76880151
17TAOK31.70301686
18NME21.70255976
19CSNK1G11.66158821
20NUAK11.65905106
21IKBKE1.55255718
22MAPK111.49893667
23FRK1.48727923
24PRKCI1.45586376
25LIMK11.41064289
26MAP3K131.36639940
27STK391.32560756
28IKBKB1.32234966
29ITK1.31972996
30NLK1.31266651
31ADRBK11.30530489
32DAPK21.23541581
33ABL21.23496162
34CSNK1G31.20261868
35MAP4K21.14237113
36PRKCQ1.10071752
37TBK11.08673588
38PINK11.07029017
39BTK1.05039438
40CSNK1G21.02383488
41NME10.98634261
42WNK30.98449015
43CSNK1A1L0.94195939
44PRKCG0.93768831
45LCK0.93324465
46PHKG10.88953919
47PHKG20.88953919
48LYN0.84712891
49TESK20.84687013
50RPS6KA50.82778421
51GRK60.79993644
52BRAF0.79740250
53ACVR1B0.77553541
54STK30.76398123
55INSRR0.72742582
56OXSR10.70520706
57MOS0.69367963
58KDR0.67438411
59TNK20.66751762
60TGFBR10.65803375
61MAPK130.64194753
62CSNK1A10.63955864
63JAK30.62792293
64DYRK1A0.59701821
65DYRK20.59481425
66PRKCA0.57479623
67PLK40.56575377
68MAPKAPK50.56475698
69MUSK0.54915949
70TYRO30.54671406
71SGK20.54460495
72CAMKK20.54142238
73PRKACA0.52173152
74PDK20.50473033
75HCK0.50299589
76CSNK1D0.48150260
77BMPR1B0.47708903
78PIK3CG0.47590655
79OBSCN0.45848610
80SGK4940.44228863
81SGK2230.44228863
82ERBB20.43696282
83NTRK30.42523716
84INSR0.40983779
85PRKD20.39089461
86PRKCE0.38346627
87ABL10.38289904
88PIK3CA0.37932216
89MATK0.37472839
90RPS6KA40.37071265
91MAP2K20.36601480
92CDK30.36113880
93FGFR20.35971777
94PRKCD0.34440260
95CDK40.34057285
96PRKCB0.33828099
97CLK10.33153254
98PAK10.33024560
99GRK70.32162214
100SGK30.31504928

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.80628096
2Primary immunodeficiency_Homo sapiens_hsa053403.73032067
3Oxidative phosphorylation_Homo sapiens_hsa001903.40393762
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.93134485
5Linoleic acid metabolism_Homo sapiens_hsa005912.90263876
6Proteasome_Homo sapiens_hsa030502.80225626
7Parkinsons disease_Homo sapiens_hsa050122.63743427
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57041427
9Sulfur relay system_Homo sapiens_hsa041222.30787199
10Allograft rejection_Homo sapiens_hsa053302.24693071
11Autoimmune thyroid disease_Homo sapiens_hsa053202.16244896
12Asthma_Homo sapiens_hsa053102.12300418
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92686754
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92670074
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86382494
16Phototransduction_Homo sapiens_hsa047441.85303756
17Alzheimers disease_Homo sapiens_hsa050101.82565099
18Graft-versus-host disease_Homo sapiens_hsa053321.81695721
19Arachidonic acid metabolism_Homo sapiens_hsa005901.81299463
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80089599
21Huntingtons disease_Homo sapiens_hsa050161.70222124
22Sulfur metabolism_Homo sapiens_hsa009201.68065821
23Nitrogen metabolism_Homo sapiens_hsa009101.67130408
24RNA polymerase_Homo sapiens_hsa030201.58982928
25Type I diabetes mellitus_Homo sapiens_hsa049401.51544797
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34990006
27Ether lipid metabolism_Homo sapiens_hsa005651.34205416
28RNA degradation_Homo sapiens_hsa030181.33173865
29Caffeine metabolism_Homo sapiens_hsa002321.32652356
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28769199
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24357333
32Fat digestion and absorption_Homo sapiens_hsa049751.19103434
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18260554
34T cell receptor signaling pathway_Homo sapiens_hsa046601.12364158
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12129927
36Basal transcription factors_Homo sapiens_hsa030221.09156414
37Tryptophan metabolism_Homo sapiens_hsa003801.06968400
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.01961558
39Regulation of autophagy_Homo sapiens_hsa041401.01141933
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99678240
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98888211
42Hematopoietic cell lineage_Homo sapiens_hsa046400.97703360
43Cardiac muscle contraction_Homo sapiens_hsa042600.97527276
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97370973
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95102919
46Homologous recombination_Homo sapiens_hsa034400.94307634
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.93639638
48Pyrimidine metabolism_Homo sapiens_hsa002400.93575211
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92211322
50Mismatch repair_Homo sapiens_hsa034300.90395978
51Selenocompound metabolism_Homo sapiens_hsa004500.87754644
52Purine metabolism_Homo sapiens_hsa002300.87751217
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87404333
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86721483
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.85567961
56Nucleotide excision repair_Homo sapiens_hsa034200.77920943
57DNA replication_Homo sapiens_hsa030300.77868489
58Butanoate metabolism_Homo sapiens_hsa006500.74700845
59Retinol metabolism_Homo sapiens_hsa008300.71680543
60Olfactory transduction_Homo sapiens_hsa047400.70091317
61Rheumatoid arthritis_Homo sapiens_hsa053230.69450200
62Chemical carcinogenesis_Homo sapiens_hsa052040.65363729
63Protein export_Homo sapiens_hsa030600.65341668
64One carbon pool by folate_Homo sapiens_hsa006700.65212322
65Metabolic pathways_Homo sapiens_hsa011000.63834375
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.63360874
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62868390
68Peroxisome_Homo sapiens_hsa041460.62391709
69Base excision repair_Homo sapiens_hsa034100.62086839
70Antigen processing and presentation_Homo sapiens_hsa046120.61348379
71Nicotine addiction_Homo sapiens_hsa050330.58320555
72Fanconi anemia pathway_Homo sapiens_hsa034600.53278520
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52158034
74Morphine addiction_Homo sapiens_hsa050320.47096702
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44482268
76Arginine and proline metabolism_Homo sapiens_hsa003300.44439099
77Folate biosynthesis_Homo sapiens_hsa007900.43398840
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40984684
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40085722
80Steroid biosynthesis_Homo sapiens_hsa001000.37144435
81Glycerolipid metabolism_Homo sapiens_hsa005610.36725116
82Taste transduction_Homo sapiens_hsa047420.35384908
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35320272
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34291993
85Staphylococcus aureus infection_Homo sapiens_hsa051500.33196836
86Tyrosine metabolism_Homo sapiens_hsa003500.32830480
87Viral myocarditis_Homo sapiens_hsa054160.31656379
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30620879
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.29960670
90beta-Alanine metabolism_Homo sapiens_hsa004100.29635501
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28411770
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27648243
93Systemic lupus erythematosus_Homo sapiens_hsa053220.27433474
94Propanoate metabolism_Homo sapiens_hsa006400.26914322
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.26893805
96Ovarian steroidogenesis_Homo sapiens_hsa049130.26500502
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.26347166
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24603733
99Fatty acid degradation_Homo sapiens_hsa000710.21458745
100Serotonergic synapse_Homo sapiens_hsa047260.20263413

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