ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.15415881
2	activated T cell proliferation (GO:0050798)	5.85892395
3	regulation of protein glycosylation (GO:0060049)	5.47736536
4	positive regulation of glycoprotein biosynthetic process (GO:0010560)	5.46289684
5	viral transcription (GO:0019083)	4.98008439
6	ribosomal small subunit biogenesis (GO:0042274)	4.77232408
7	translational termination (GO:0006415)	4.71783683
8	ncRNA 3-end processing (GO:0043628)	4.68895392
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.40374287
10	transcription from RNA polymerase I promoter (GO:0006360)	4.38983514
11	positive regulation of glycoprotein metabolic process (GO:1903020)	4.35306802
12	cotranslational protein targeting to membrane (GO:0006613)	4.34704907
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.31169858
14	protein targeting to ER (GO:0045047)	4.28336166
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.25174520
16	NADH dehydrogenase complex assembly (GO:0010257)	4.25174520
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.25174520
18	DNA deamination (GO:0045006)	4.23404663
19	ATP synthesis coupled proton transport (GO:0015986)	4.22375221
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.22375221
21	protein localization to endoplasmic reticulum (GO:0070972)	4.12099303
22	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.09300511
23	translational elongation (GO:0006414)	4.04586045
24	protein complex biogenesis (GO:0070271)	3.92267443
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.91352227
26	negative regulation of execution phase of apoptosis (GO:1900118)	3.79100079
27	chaperone-mediated protein transport (GO:0072321)	3.77341617
28	xenobiotic catabolic process (GO:0042178)	3.68267948
29	respiratory electron transport chain (GO:0022904)	3.60490558
30	ubiquinone biosynthetic process (GO:0006744)	3.60301845
31	electron transport chain (GO:0022900)	3.57303038
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.56152753
33	maturation of SSU-rRNA (GO:0030490)	3.49615479
34	regulation of regulatory T cell differentiation (GO:0045589)	3.41022735
35	cellular protein complex disassembly (GO:0043624)	3.38482127
36	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.37551556
37	viral life cycle (GO:0019058)	3.31276162
38	diacylglycerol metabolic process (GO:0046339)	3.30794528
39	ubiquinone metabolic process (GO:0006743)	3.26705769
40	water-soluble vitamin biosynthetic process (GO:0042364)	3.23408330
41	translational initiation (GO:0006413)	3.21740042
42	behavioral response to nicotine (GO:0035095)	3.21007560
43	protein polyglutamylation (GO:0018095)	3.15379049
44	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.15147676
45	protein heterotetramerization (GO:0051290)	3.12493549
46	protein-cofactor linkage (GO:0018065)	3.11740666
47	platelet dense granule organization (GO:0060155)	3.07563224
48	isoprenoid biosynthetic process (GO:0008299)	3.06747119
49	ribosomal large subunit biogenesis (GO:0042273)	3.03631661
50	translation (GO:0006412)	3.03140311
51	cellular anion homeostasis (GO:0030002)	3.02267479
52	regulation of interleukin-8 secretion (GO:2000482)	3.02137584
53	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.95546724
54	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.94180630
55	quinone biosynthetic process (GO:1901663)	2.91367812
56	nonmotile primary cilium assembly (GO:0035058)	2.87528028
57	response to nitrosative stress (GO:0051409)	2.86550646
58	regulation of metalloenzyme activity (GO:0048552)	2.84456897
59	heterotypic cell-cell adhesion (GO:0034113)	2.82781912
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.80555747
61	protein targeting to membrane (GO:0006612)	2.73593209
62	deoxyribose phosphate biosynthetic process (GO:0046385)	2.72394742
63	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.72394742
64	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71840521
65	negative regulation of acute inflammatory response (GO:0002674)	2.68209102
66	GPI anchor metabolic process (GO:0006505)	2.64618724
67	protein complex disassembly (GO:0043241)	2.64128050
68	intracellular protein transmembrane import (GO:0044743)	2.62497609
69	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.61756939
70	autophagic vacuole fusion (GO:0000046)	2.56286359
71	respiratory chain complex IV assembly (GO:0008535)	2.55281325
72	GTP biosynthetic process (GO:0006183)	2.54207104
73	cellular component biogenesis (GO:0044085)	2.52880119
74	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.52867423
75	protein neddylation (GO:0045116)	2.51270575
76	hydrogen ion transmembrane transport (GO:1902600)	2.49641985
77	killing of cells of other organism (GO:0031640)	2.49574782
78	disruption of cells of other organism (GO:0044364)	2.49574782
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.49294933
80	macromolecular complex disassembly (GO:0032984)	2.48308620
81	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.48299279
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.47855824
83	glycerophospholipid catabolic process (GO:0046475)	2.47690432
84	ATP biosynthetic process (GO:0006754)	2.45850156
85	GPI anchor biosynthetic process (GO:0006506)	2.45161252
86	preassembly of GPI anchor in ER membrane (GO:0016254)	2.41263638
87	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.41169090
88	icosanoid secretion (GO:0032309)	2.40547626
89	arachidonic acid secretion (GO:0050482)	2.40547626
90	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.39963589
91	termination of RNA polymerase I transcription (GO:0006363)	2.38555752
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.37555702
93	termination of RNA polymerase III transcription (GO:0006386)	2.37555702
94	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.37185122
95	indolalkylamine metabolic process (GO:0006586)	2.37101488
96	eosinophil chemotaxis (GO:0048245)	2.36283672
97	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.36073333
98	S-adenosylmethionine metabolic process (GO:0046500)	2.36028156
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.35598358
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.35598358

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.15419096
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.11518818
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.77005275
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.50866401
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.35546072
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.22429620
7	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.38972291
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34036212
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.33999509
10	VDR_22108803_ChIP-Seq_LS180_Human	2.33983547
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.30824116
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27880086
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22551849
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.06928206
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06006475
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.00647590
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.94687751
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.90523740
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.89884833
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.87528907
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85096385
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84328449
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79955699
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.71098236
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.62082763
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57048440
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52355131
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51845920
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.49911241
30	EWS_26573619_Chip-Seq_HEK293_Human	1.48892195
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47278347
32	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.46924820
33	FUS_26573619_Chip-Seq_HEK293_Human	1.44426249
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42216030
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.41811896
36	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.41043168
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.39550832
38	TAF2_19829295_ChIP-Seq_ESCs_Human	1.39242126
39	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.33340643
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32822122
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32467103
42	AR_20517297_ChIP-Seq_VCAP_Human	1.31952611
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30097291
44	GATA3_26560356_Chip-Seq_TH2_Human	1.28568386
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28263028
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28263028
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26510829
48	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.22081352
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.21257671
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20478375
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.19748149
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18974754
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18974754
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17703315
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.17294162
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16877383
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15825881
58	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.11785949
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11262505
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.11246016
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11048911
62	P300_19829295_ChIP-Seq_ESCs_Human	1.10501075
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09338595
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.08958453
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08958453
66	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.08835984
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.07857601
68	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.07399487
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.07185888
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07015242
71	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.06312049
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05995207
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04198034
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04029849
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.03386620
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.02966326
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02783100
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02511582
79	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01693212
80	BCAT_22108803_ChIP-Seq_LS180_Human	1.00439911
81	TAF15_26573619_Chip-Seq_HEK293_Human	1.00435723
82	RUNX_20019798_ChIP-Seq_JUKART_Human	0.99523589
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99148541
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98136088
85	GATA3_26560356_Chip-Seq_TH1_Human	0.96375755
86	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.94489537
87	ERA_21632823_ChIP-Seq_H3396_Human	0.93799930
88	TTF2_22483619_ChIP-Seq_HELA_Human	0.93336070
89	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.93185483
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.92280900
91	EZH2_22144423_ChIP-Seq_EOC_Human	0.92168007
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.91329953
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91047516
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90891214
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88862957
96	RBPJ_21746931_ChIP-Seq_IB4_Human	0.88213734
97	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.87741752
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.86615329
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.86315473
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.86074126

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.15145479
2	MP0003646_muscle_fatigue	3.00584029
3	MP0005671_abnormal_response_to	2.99902082
4	MP0003195_calcinosis	2.85757596
5	MP0002933_joint_inflammation	2.84434965
6	MP0003011_delayed_dark_adaptation	2.69162868
7	MP0006082_CNS_inflammation	2.52995157
8	MP0001835_abnormal_antigen_presentation	2.47076199
9	MP0002876_abnormal_thyroid_physiology	2.40203410
10	MP0005253_abnormal_eye_physiology	2.37133804
11	MP0002837_dystrophic_cardiac_calcinosis	2.31574573
12	MP0004142_abnormal_muscle_tone	2.31086923
13	MP0001529_abnormal_vocalization	2.29756159
14	MP0006072_abnormal_retinal_apoptosis	2.23703993
15	MP0008875_abnormal_xenobiotic_pharmacok	2.21640933
16	MP0001905_abnormal_dopamine_level	2.20899822
17	MP0010386_abnormal_urinary_bladder	2.13345651
18	MP0001873_stomach_inflammation	2.11416192
19	MP0006292_abnormal_olfactory_placode	2.10786211
20	MP0004885_abnormal_endolymph	2.07103466
21	MP0005646_abnormal_pituitary_gland	1.93639614
22	MP0008877_abnormal_DNA_methylation	1.91028660
23	MP0008872_abnormal_physiological_respon	1.85458640
24	MP0002102_abnormal_ear_morphology	1.84735709
25	MP0009046_muscle_twitch	1.81409266
26	MP0005645_abnormal_hypothalamus_physiol	1.74618968
27	MP0002163_abnormal_gland_morphology	1.74542027
28	MP0005551_abnormal_eye_electrophysiolog	1.72215227
29	MP0005000_abnormal_immune_tolerance	1.61889104
30	MP0003724_increased_susceptibility_to	1.59988874
31	MP0005075_abnormal_melanosome_morpholog	1.58551242
32	MP0002277_abnormal_respiratory_mucosa	1.58134052
33	MP0001800_abnormal_humoral_immune	1.53982695
34	MP0000372_irregular_coat_pigmentation	1.49289509
35	MP0009785_altered_susceptibility_to	1.47732345
36	MP0001727_abnormal_embryo_implantation	1.43546168
37	MP0000685_abnormal_immune_system	1.42080572
38	MP0001851_eye_inflammation	1.41763463
39	MP0006036_abnormal_mitochondrial_physio	1.27541311
40	MP0003866_abnormal_defecation	1.24700726
41	MP0002148_abnormal_hypersensitivity_rea	1.23175826
42	MP0005379_endocrine/exocrine_gland_phen	1.22645325
43	MP0002723_abnormal_immune_serum	1.19881244
44	MP0005408_hypopigmentation	1.18647794
45	MP0001986_abnormal_taste_sensitivity	1.17520031
46	MP0002095_abnormal_skin_pigmentation	1.13049578
47	MP0005386_behavior/neurological_phenoty	1.13031306
48	MP0004924_abnormal_behavior	1.13031306
49	MP0000230_abnormal_systemic_arterial	1.11398088
50	MP0005025_abnormal_response_to	1.10206305
51	MP0002452_abnormal_antigen_presenting	1.06947534
52	MP0009745_abnormal_behavioral_response	1.06928062
53	MP0001790_abnormal_immune_system	1.04673747
54	MP0005387_immune_system_phenotype	1.04673747
55	MP0001968_abnormal_touch/_nociception	1.04267454
56	MP0006035_abnormal_mitochondrial_morpho	1.02550519
57	MP0002736_abnormal_nociception_after	1.01454683
58	MP0006276_abnormal_autonomic_nervous	1.00264177
59	MP0003567_abnormal_fetal_cardiomyocyte	0.99782066
60	MP0002693_abnormal_pancreas_physiology	0.99440524
61	MP0008469_abnormal_protein_level	0.97433830
62	MP0005636_abnormal_mineral_homeostasis	0.97339086
63	MP0002420_abnormal_adaptive_immunity	0.94130627
64	MP0001845_abnormal_inflammatory_respons	0.93062779
65	MP0004742_abnormal_vestibular_system	0.93055662
66	MP0003878_abnormal_ear_physiology	0.92692490
67	MP0005377_hearing/vestibular/ear_phenot	0.92692490
68	MP0005389_reproductive_system_phenotype	0.91373504
69	MP0005197_abnormal_uvea_morphology	0.91105632
70	MP0003763_abnormal_thymus_physiology	0.90794929
71	MP0002234_abnormal_pharynx_morphology	0.89804353
72	MP0001984_abnormal_olfaction	0.88936085
73	MP0001819_abnormal_immune_cell	0.88411065
74	MP0002419_abnormal_innate_immunity	0.88312624
75	MP0000631_abnormal_neuroendocrine_gland	0.87120210
76	MP0002557_abnormal_social/conspecific_i	0.87119070
77	MP0005195_abnormal_posterior_eye	0.86657744
78	MP0001486_abnormal_startle_reflex	0.85661592
79	MP0004145_abnormal_muscle_electrophysio	0.85433403
80	MP0002160_abnormal_reproductive_system	0.84616513
81	MP0005174_abnormal_tail_pigmentation	0.83910577
82	MP0000538_abnormal_urinary_bladder	0.83517657
83	MP0001485_abnormal_pinna_reflex	0.83028027
84	MP0001765_abnormal_ion_homeostasis	0.80059011
85	MP0003879_abnormal_hair_cell	0.80036793
86	MP0002272_abnormal_nervous_system	0.80024588
87	MP0001440_abnormal_grooming_behavior	0.79767031
88	MP0002572_abnormal_emotion/affect_behav	0.79214836
89	MP0004019_abnormal_vitamin_homeostasis	0.77412634
90	MP0009764_decreased_sensitivity_to	0.76481001
91	MP0004947_skin_inflammation	0.76238179
92	MP0005391_vision/eye_phenotype	0.75758720
93	MP0002938_white_spotting	0.75012442
94	MP0003283_abnormal_digestive_organ	0.73390373
95	MP0005448_abnormal_energy_balance	0.72613115
96	MP0008995_early_reproductive_senescence	0.72361455
97	MP0001919_abnormal_reproductive_system	0.70869036
98	MP0005360_urolithiasis	0.69328349
99	MP0000639_abnormal_adrenal_gland	0.68493162
100	MP0003186_abnormal_redox_activity	0.67724909

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Recurrent gram-negative bacterial infections (HP:0005420)	5.68029363
2	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.02193722
3	Acute necrotizing encephalopathy (HP:0006965)	4.49295457
4	Periodontitis (HP:0000704)	4.06707071
5	Progressive macrocephaly (HP:0004481)	3.98899650
6	Chronic bronchitis (HP:0004469)	3.91319062
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.88216874
8	Congenital stationary night blindness (HP:0007642)	3.78303905
9	3-Methylglutaconic aciduria (HP:0003535)	3.73674805
10	Mitochondrial inheritance (HP:0001427)	3.67759990
11	Attenuation of retinal blood vessels (HP:0007843)	3.65548959
12	Acute encephalopathy (HP:0006846)	3.65478987
13	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.51921902
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.42058958
15	Abnormality of macular pigmentation (HP:0008002)	3.39602552
16	Leukocytosis (HP:0001974)	3.32260816
17	Congenital, generalized hypertrichosis (HP:0004540)	3.22854860
18	Increased CSF lactate (HP:0002490)	3.22157190
19	Autoimmune hemolytic anemia (HP:0001890)	3.12125650
20	Hepatocellular necrosis (HP:0001404)	3.05199404
21	Autoimmune thrombocytopenia (HP:0001973)	3.04202850
22	Recurrent abscess formation (HP:0002722)	3.03996600
23	Reticulocytopenia (HP:0001896)	3.02465947
24	Constricted visual fields (HP:0001133)	3.02087485
25	Pancreatic cysts (HP:0001737)	3.00461657
26	Optic disc pallor (HP:0000543)	2.97485075
27	Abnormal respiratory motile cilium physiology (HP:0012261)	2.89501191
28	Increased IgM level (HP:0003496)	2.88106836
29	Abolished electroretinogram (ERG) (HP:0000550)	2.84134395
30	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.82730640
31	Sparse scalp hair (HP:0002209)	2.78123804
32	Hepatic necrosis (HP:0002605)	2.76015112
33	Abnormality of midbrain morphology (HP:0002418)	2.75984820
34	Molar tooth sign on MRI (HP:0002419)	2.75984820
35	Rhinitis (HP:0012384)	2.70554946
36	Cerebral edema (HP:0002181)	2.65045279
37	Abnormality of the intervertebral disk (HP:0005108)	2.53086449
38	Eosinophilia (HP:0001880)	2.51111415
39	Hypoproteinemia (HP:0003075)	2.50709200
40	Increased hepatocellular lipid droplets (HP:0006565)	2.47414426
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.36689279
42	Asplenia (HP:0001746)	2.36308395
43	Aplasia/hypoplasia of the uterus (HP:0008684)	2.34065685
44	Nephronophthisis (HP:0000090)	2.31006700
45	Lipid accumulation in hepatocytes (HP:0006561)	2.30283621
46	Nasal speech (HP:0001611)	2.29268660
47	Pancreatic fibrosis (HP:0100732)	2.27295403
48	Gingivitis (HP:0000230)	2.26165056
49	Abnormality of eosinophils (HP:0001879)	2.25395307
50	Increased serum lactate (HP:0002151)	2.20015190
51	Abnormal number of erythroid precursors (HP:0012131)	2.19869646
52	Stomatitis (HP:0010280)	2.18148573
53	Maternal diabetes (HP:0009800)	2.17836757
54	Macrocytic anemia (HP:0001972)	2.16967186
55	True hermaphroditism (HP:0010459)	2.16388340
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.15704894
57	Abnormality of cells of the erythroid lineage (HP:0012130)	2.10424876
58	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.09730120
59	Hypoplasia of the fovea (HP:0007750)	2.09730120
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09175400
61	Abnormality of magnesium homeostasis (HP:0004921)	2.08882756
62	Cerebellar dysplasia (HP:0007033)	2.04790512
63	Abnormality of T cell physiology (HP:0011840)	2.00896400
64	Pendular nystagmus (HP:0012043)	2.00420937
65	Respiratory failure (HP:0002878)	1.96896091
66	IgG deficiency (HP:0004315)	1.96814206
67	Exertional dyspnea (HP:0002875)	1.96673325
68	Bronchitis (HP:0012387)	1.96378138
69	Decreased central vision (HP:0007663)	1.96242418
70	Absent thumb (HP:0009777)	1.95357362
71	Hypothermia (HP:0002045)	1.95252546
72	Bony spicule pigmentary retinopathy (HP:0007737)	1.95042794
73	Granulocytopenia (HP:0001913)	1.94319814
74	Renal Fanconi syndrome (HP:0001994)	1.93197149
75	Increased corneal curvature (HP:0100692)	1.92974268
76	Keratoconus (HP:0000563)	1.92974268
77	Hyperglycinemia (HP:0002154)	1.92353494
78	Lactic acidosis (HP:0003128)	1.91184765
79	Abnormality of the renal cortex (HP:0011035)	1.91083055
80	Abnormality of the renal medulla (HP:0100957)	1.89321204
81	Elevated erythrocyte sedimentation rate (HP:0003565)	1.89167050
82	Abnormality of the renal collecting system (HP:0004742)	1.87986922
83	Cone-rod dystrophy (HP:0000548)	1.83064968
84	Lethargy (HP:0001254)	1.82732029
85	Abnormality of T cell number (HP:0011839)	1.82242279
86	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78807683
87	Renal cortical cysts (HP:0000803)	1.78380634
88	Pallor (HP:0000980)	1.74643824
89	Leukodystrophy (HP:0002415)	1.73948837
90	Recurrent otitis media (HP:0000403)	1.72205974
91	Abnormality of the fovea (HP:0000493)	1.71710457
92	Anencephaly (HP:0002323)	1.71379345
93	Abnormality of DNA repair (HP:0003254)	1.71363479
94	Hypomagnesemia (HP:0002917)	1.70642065
95	Thyroiditis (HP:0100646)	1.68730549
96	Bronchiectasis (HP:0002110)	1.68568968
97	Abnormal drinking behavior (HP:0030082)	1.66530384
98	Polydipsia (HP:0001959)	1.66530384
99	Medial flaring of the eyebrow (HP:0010747)	1.66390940
100	Hypochromic anemia (HP:0001931)	1.65199836

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	4.50289807
2	TXK	4.07409022
3	PRKCH	3.64122138
4	FRK	3.45378928
5	MAP4K2	2.97374247
6	GRK1	2.87574651
7	FES	2.78793015
8	TLK1	2.64790675
9	MAP4K1	2.62014162
10	TAOK3	2.30008480
11	ZAK	2.21437788
12	ADRBK2	2.10417860
13	DAPK1	1.86257660
14	TYRO3	1.74795423
15	INSRR	1.73931342
16	NUAK1	1.73419265
17	BCKDK	1.67947740
18	KIT	1.54250647
19	WNK3	1.47545408
20	DAPK2	1.39410192
21	PASK	1.39191893
22	NTRK3	1.26627494
23	TEC	1.26384651
24	ADRBK1	1.23341847
25	TIE1	1.21124135
26	PINK1	1.14304089
27	BMPR1B	1.12435372
28	WNK4	1.12133862
29	NME1	1.06937834
30	MAP2K6	1.06643060
31	CSK	1.06580352
32	LCK	1.05727395
33	PHKG1	1.04582135
34	PHKG2	1.04582135
35	VRK1	1.04449973
36	DYRK2	1.03154902
37	IKBKB	1.01800630
38	CDK19	0.96434152
39	MST4	0.94225518
40	PRKCQ	0.91791620
41	VRK2	0.90696139
42	EPHA3	0.84476390
43	OXSR1	0.82617767
44	SYK	0.82448442
45	TRIM28	0.79236551
46	ITK	0.69478754
47	MUSK	0.68954708
48	FLT3	0.67340570
49	PAK3	0.66833623
50	CSF1R	0.64694945
51	CAMK2D	0.63999988
52	RPS6KA5	0.63974179
53	LYN	0.63889066
54	EIF2AK3	0.61494151
55	KDR	0.60983503
56	CAMK2A	0.59805232
57	MAPK13	0.59629952
58	OBSCN	0.59318604
59	PRKCD	0.59273105
60	PRKACA	0.57368050
61	PRKCG	0.56761007
62	GRK7	0.55680649
63	MAP3K12	0.52556330
64	FGFR2	0.50812908
65	TNK2	0.48787404
66	PRKCE	0.47147204
67	CSNK1A1	0.46176370
68	IGF1R	0.46156588
69	CAMK2G	0.45312490
70	CSNK1G3	0.45032132
71	MYLK	0.44366696
72	PRKCA	0.43903894
73	PRKCB	0.43194596
74	MAPKAPK5	0.42524553
75	MAP3K11	0.40711700
76	GRK6	0.40479809
77	CAMK2B	0.39978029
78	FER	0.39849117
79	MAPK4	0.39769569
80	STK16	0.39330991
81	RPS6KA6	0.38609668
82	EIF2AK1	0.38233071
83	DAPK3	0.38061828
84	PLK4	0.37930905
85	PLK3	0.36468977
86	MAPK15	0.36120660
87	CSNK1G2	0.36094315
88	PIM2	0.35658282
89	CDK3	0.34745320
90	ERBB2	0.34163521
91	CSNK1G1	0.32561174
92	STK39	0.31879726
93	NLK	0.31127793
94	CSNK2A2	0.30422990
95	TGFBR1	0.28300765
96	PRKACG	0.27797655
97	CAMKK2	0.27758233
98	ABL2	0.27294013
99	AURKA	0.26240248
100	PIK3CA	0.25820785

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	4.28440402
2	Ribosome_Homo sapiens_hsa03010	3.90692553
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.46688191
4	Type I diabetes mellitus_Homo sapiens_hsa04940	2.97013687
5	Parkinsons disease_Homo sapiens_hsa05012	2.90473143
6	Allograft rejection_Homo sapiens_hsa05330	2.88896085
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.88828649
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.72758575
9	Asthma_Homo sapiens_hsa05310	2.31596662
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.14620081
11	Proteasome_Homo sapiens_hsa03050	2.10154898
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.97775850
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93595466
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.91973170
15	Protein export_Homo sapiens_hsa03060	1.91784395
16	Viral myocarditis_Homo sapiens_hsa05416	1.88973360
17	Alzheimers disease_Homo sapiens_hsa05010	1.82243950
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80738092
19	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.78185005
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77365965
21	Huntingtons disease_Homo sapiens_hsa05016	1.76675260
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.71768564
23	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.65859766
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56055269
25	Phototransduction_Homo sapiens_hsa04744	1.54964925
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.47207096
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46191912
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.37733588
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35627306
30	Legionellosis_Homo sapiens_hsa05134	1.34525972
31	Purine metabolism_Homo sapiens_hsa00230	1.29919294
32	Malaria_Homo sapiens_hsa05144	1.27805228
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.26088550
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.24145347
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.22153233
36	Caffeine metabolism_Homo sapiens_hsa00232	1.12357348
37	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.09170664
38	Antigen processing and presentation_Homo sapiens_hsa04612	1.08429401
39	Leishmaniasis_Homo sapiens_hsa05140	1.06056079
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03331145
41	RNA degradation_Homo sapiens_hsa03018	1.01757603
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.01013286
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00406221
44	Homologous recombination_Homo sapiens_hsa03440	1.00101508
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.99473737
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99081113
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97727455
48	One carbon pool by folate_Homo sapiens_hsa00670	0.97319784
49	Spliceosome_Homo sapiens_hsa03040	0.90709498
50	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.84594875
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83959499
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.80891143
53	Basal transcription factors_Homo sapiens_hsa03022	0.80877527
54	Butanoate metabolism_Homo sapiens_hsa00650	0.77359751
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76534958
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73664582
57	Pertussis_Homo sapiens_hsa05133	0.73517359
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.72255824
59	Olfactory transduction_Homo sapiens_hsa04740	0.70711704
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70411137
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.70323515
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66757354
63	Glutathione metabolism_Homo sapiens_hsa00480	0.65762420
64	Peroxisome_Homo sapiens_hsa04146	0.64571927
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63245197
66	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62412047
67	Mismatch repair_Homo sapiens_hsa03430	0.60608862
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60388129
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59055731
70	Retinol metabolism_Homo sapiens_hsa00830	0.55233095
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54951544
72	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54351849
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53051599
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50533412
75	Fatty acid elongation_Homo sapiens_hsa00062	0.50507363
76	Nicotine addiction_Homo sapiens_hsa05033	0.50453201
77	Metabolic pathways_Homo sapiens_hsa01100	0.49471664
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.45169552
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.44094707
80	Regulation of autophagy_Homo sapiens_hsa04140	0.43869258
81	Taste transduction_Homo sapiens_hsa04742	0.43716680
82	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.43111957
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41972203
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38528397
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.37015837
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35883491
87	ABC transporters_Homo sapiens_hsa02010	0.32780569
88	Serotonergic synapse_Homo sapiens_hsa04726	0.31014807
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.30777662
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.27905959
91	Complement and coagulation cascades_Homo sapiens_hsa04610	0.27452404
92	Insulin secretion_Homo sapiens_hsa04911	0.27054585
93	Sulfur metabolism_Homo sapiens_hsa00920	0.24850219
94	RNA transport_Homo sapiens_hsa03013	0.24376718
95	DNA replication_Homo sapiens_hsa03030	0.24232544
96	Propanoate metabolism_Homo sapiens_hsa00640	0.23797619
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.22061629
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.21703624
99	Morphine addiction_Homo sapiens_hsa05032	0.20077390
100	Phagosome_Homo sapiens_hsa04145	0.19505362

RPL15P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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