RPL15P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)4.97146885
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.97146885
3DNA deamination (GO:0045006)4.80334777
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.75281938
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70009686
6viral transcription (GO:0019083)4.53445338
7regulation of memory T cell differentiation (GO:0043380)4.47463833
8ribosomal small subunit assembly (GO:0000028)4.43695495
9translational termination (GO:0006415)4.39890385
10behavioral response to nicotine (GO:0035095)4.38319124
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.10160105
12positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.09430583
13regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.05650607
14positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.04746885
15chaperone-mediated protein transport (GO:0072321)4.04255953
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03331010
17cotranslational protein targeting to membrane (GO:0006613)4.02068812
18protein targeting to ER (GO:0045047)4.00518483
19positive regulation of defense response to virus by host (GO:0002230)3.97681126
20L-fucose metabolic process (GO:0042354)3.89093396
21L-fucose catabolic process (GO:0042355)3.89093396
22fucose catabolic process (GO:0019317)3.89093396
23translational elongation (GO:0006414)3.85456838
24ribosomal small subunit biogenesis (GO:0042274)3.80620762
25regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.79338870
26protein localization to endoplasmic reticulum (GO:0070972)3.78625913
27water-soluble vitamin biosynthetic process (GO:0042364)3.78540858
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77873241
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67424391
30maturation of SSU-rRNA (GO:0030490)3.66534603
31preassembly of GPI anchor in ER membrane (GO:0016254)3.65351147
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63204352
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63204352
34protein neddylation (GO:0045116)3.62480802
35electron transport chain (GO:0022900)3.58773877
36protein complex biogenesis (GO:0070271)3.58384531
37positive regulation of interleukin-17 production (GO:0032740)3.53616310
38respiratory electron transport chain (GO:0022904)3.52049580
39positive regulation of T-helper 1 type immune response (GO:0002827)3.48947643
40regulation of activation of Janus kinase activity (GO:0010533)3.31533238
41positive regulation of prostaglandin secretion (GO:0032308)3.27365670
42ribosomal large subunit biogenesis (GO:0042273)3.24938177
43viral life cycle (GO:0019058)3.24559779
44positive regulation of T cell mediated cytotoxicity (GO:0001916)3.23532052
45protein-cofactor linkage (GO:0018065)3.23519585
46mitochondrial respiratory chain complex assembly (GO:0033108)3.23302264
47cellular protein complex disassembly (GO:0043624)3.18412008
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.17316813
49NADH dehydrogenase complex assembly (GO:0010257)3.17316813
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17316813
51translation (GO:0006412)3.16216066
52translational initiation (GO:0006413)3.14841054
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07815851
54positive regulation of cell fate commitment (GO:0010455)3.07755973
55DNA double-strand break processing (GO:0000729)3.07155853
56base-excision repair, AP site formation (GO:0006285)3.06464607
57proteasome assembly (GO:0043248)3.05657331
58termination of RNA polymerase III transcription (GO:0006386)3.02529984
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.02529984
60regulation of chronic inflammatory response (GO:0002676)3.00543024
61pyrimidine nucleotide catabolic process (GO:0006244)2.96363730
62ATP biosynthetic process (GO:0006754)2.96256047
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92342338
64response to pheromone (GO:0019236)2.88252547
65purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87100073
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87036488
67respiratory chain complex IV assembly (GO:0008535)2.83720075
68regulation of T cell mediated cytotoxicity (GO:0001914)2.82222942
69pseudouridine synthesis (GO:0001522)2.81223219
70rRNA processing (GO:0006364)2.81049482
71positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79122270
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77467438
73rRNA metabolic process (GO:0016072)2.76955275
74piRNA metabolic process (GO:0034587)2.75069339
75cytochrome complex assembly (GO:0017004)2.74341670
76positive regulation of fatty acid transport (GO:2000193)2.73288563
77male meiosis I (GO:0007141)2.72733552
78cellular component biogenesis (GO:0044085)2.72025235
79positive regulation of activated T cell proliferation (GO:0042104)2.68648313
80regulation of immunoglobulin secretion (GO:0051023)2.68108111
81proton transport (GO:0015992)2.67106479
82regulation of T-helper 1 type immune response (GO:0002825)2.66632376
83negative regulation of T cell differentiation in thymus (GO:0033085)2.66535967
84hydrogen ion transmembrane transport (GO:1902600)2.64409339
85intracellular protein transmembrane import (GO:0044743)2.63928245
86positive regulation of icosanoid secretion (GO:0032305)2.61851094
87hydrogen transport (GO:0006818)2.61831667
88GPI anchor metabolic process (GO:0006505)2.60355129
89response to xenobiotic stimulus (GO:0009410)2.58566410
90protein complex disassembly (GO:0043241)2.57990748
91GTP biosynthetic process (GO:0006183)2.57841217
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57002462
93negative regulation of interleukin-10 production (GO:0032693)2.56646372
94cullin deneddylation (GO:0010388)2.56602214
95regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.54796685
96protein targeting to membrane (GO:0006612)2.54780513
97GPI anchor biosynthetic process (GO:0006506)2.54600375
98positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.53602507
99ribonucleoprotein complex biogenesis (GO:0022613)2.52545891
100tRNA processing (GO:0008033)2.52346748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.94773898
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67612815
3ZNF274_21170338_ChIP-Seq_K562_Hela3.53912821
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.38281579
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02504034
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95829576
7VDR_22108803_ChIP-Seq_LS180_Human2.72166976
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61632276
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59641336
10VDR_23849224_ChIP-Seq_CD4+_Human2.54056916
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.44194529
12IGF1R_20145208_ChIP-Seq_DFB_Human2.36417495
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24093009
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.22086143
15ELK1_19687146_ChIP-ChIP_HELA_Human1.98734268
16BP1_19119308_ChIP-ChIP_Hs578T_Human1.92753134
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91868647
18EWS_26573619_Chip-Seq_HEK293_Human1.90542289
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.87735493
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87722230
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83927478
22FOXP3_21729870_ChIP-Seq_TREG_Human1.78230282
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77324913
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77029795
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76984464
26MYC_18940864_ChIP-ChIP_HL60_Human1.76690238
27EZH2_22144423_ChIP-Seq_EOC_Human1.69077296
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.66109303
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.65585491
30TP53_22573176_ChIP-Seq_HFKS_Human1.61815674
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58041642
32IRF1_19129219_ChIP-ChIP_H3396_Human1.56373791
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.49100436
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41952716
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41189690
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.39060076
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39060076
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37746399
39AR_20517297_ChIP-Seq_VCAP_Human1.37283567
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35944466
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35777119
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35511783
43ER_23166858_ChIP-Seq_MCF-7_Human1.32621837
44NANOG_19829295_ChIP-Seq_ESCs_Human1.32215103
45SOX2_19829295_ChIP-Seq_ESCs_Human1.32215103
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.32202818
47TAF15_26573619_Chip-Seq_HEK293_Human1.31861306
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29540488
49GATA3_26560356_Chip-Seq_TH2_Human1.27226742
50TTF2_22483619_ChIP-Seq_HELA_Human1.25357785
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25162241
52TAF2_19829295_ChIP-Seq_ESCs_Human1.25093918
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24799429
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23824173
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22573520
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21194806
57FUS_26573619_Chip-Seq_HEK293_Human1.20407288
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19189954
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.17916906
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17525750
61P300_19829295_ChIP-Seq_ESCs_Human1.17003296
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16890478
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16550088
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15841093
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15064672
66MYC_19829295_ChIP-Seq_ESCs_Human1.14276073
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14079492
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11976381
69NCOR_22424771_ChIP-Seq_293T_Human1.10935490
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.09499689
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.09422807
72ERG_20517297_ChIP-Seq_VCAP_Human1.08813976
73NANOG_20526341_ChIP-Seq_ESCs_Human1.08376731
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07887365
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07801189
76CBP_20019798_ChIP-Seq_JUKART_Human1.06751605
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06751605
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06209391
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01880659
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01508714
81GABP_19822575_ChIP-Seq_HepG2_Human1.01472228
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01053747
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99868825
84ERA_21632823_ChIP-Seq_H3396_Human0.99811840
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99765466
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99087153
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.98203688
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98083376
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98010685
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96784910
91OCT4_20526341_ChIP-Seq_ESCs_Human0.96454234
92GBX2_23144817_ChIP-Seq_PC3_Human0.96058805
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96048661
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95170579
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93651510
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92882471
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92175284
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91355443
99HOXB7_26014856_ChIP-Seq_BT474_Human0.91226504
100RNF2_27304074_Chip-Seq_NSC_Mouse0.89743333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.30273122
2MP0005671_abnormal_response_to2.93324969
3MP0008877_abnormal_DNA_methylation2.86653656
4MP0008875_abnormal_xenobiotic_pharmacok2.83336433
5MP0003646_muscle_fatigue2.59437544
6MP0009379_abnormal_foot_pigmentation2.30003833
7MP0001835_abnormal_antigen_presentation2.25841491
8MP0004885_abnormal_endolymph2.21703037
9MP0006072_abnormal_retinal_apoptosis2.21013231
10MP0002102_abnormal_ear_morphology2.19400862
11MP0001984_abnormal_olfaction2.19313672
12MP0008872_abnormal_physiological_respon2.05931646
13MP0009785_altered_susceptibility_to2.00015247
14MP0000685_abnormal_immune_system1.95756358
15MP0002876_abnormal_thyroid_physiology1.93034616
16MP0005646_abnormal_pituitary_gland1.88819111
17MP0002837_dystrophic_cardiac_calcinosis1.85818330
18MP0008789_abnormal_olfactory_epithelium1.75519647
19MP0004147_increased_porphyrin_level1.74107544
20MP0001790_abnormal_immune_system1.73980201
21MP0005387_immune_system_phenotype1.73980201
22MP0003011_delayed_dark_adaptation1.73250125
23MP0004142_abnormal_muscle_tone1.72098471
24MP0005551_abnormal_eye_electrophysiolog1.70236395
25MP0002148_abnormal_hypersensitivity_rea1.69610147
26MP0003195_calcinosis1.69574007
27MP0001968_abnormal_touch/_nociception1.67680163
28MP0001986_abnormal_taste_sensitivity1.66667835
29MP0005645_abnormal_hypothalamus_physiol1.65415293
30MP0002163_abnormal_gland_morphology1.62555282
31MP0005389_reproductive_system_phenotype1.59791022
32MP0001800_abnormal_humoral_immune1.59753572
33MP0003787_abnormal_imprinting1.58678921
34MP0002736_abnormal_nociception_after1.58427783
35MP0009764_decreased_sensitivity_to1.47986057
36MP0001919_abnormal_reproductive_system1.43308148
37MP0002160_abnormal_reproductive_system1.41701839
38MP0005084_abnormal_gallbladder_morpholo1.41037272
39MP0005000_abnormal_immune_tolerance1.40006203
40MP0002272_abnormal_nervous_system1.39376352
41MP0001501_abnormal_sleep_pattern1.35036502
42MP0004145_abnormal_muscle_electrophysio1.31587801
43MP0000372_irregular_coat_pigmentation1.29502522
44MP0006276_abnormal_autonomic_nervous1.28239579
45MP0003878_abnormal_ear_physiology1.28051953
46MP0005377_hearing/vestibular/ear_phenot1.28051953
47MP0008995_early_reproductive_senescence1.24585902
48MP0005085_abnormal_gallbladder_physiolo1.22224782
49MP0002723_abnormal_immune_serum1.20923938
50MP0003252_abnormal_bile_duct1.20482699
51MP0005253_abnormal_eye_physiology1.18241189
52MP0005394_taste/olfaction_phenotype1.17835934
53MP0005499_abnormal_olfactory_system1.17835934
54MP0009745_abnormal_behavioral_response1.17110658
55MP0002277_abnormal_respiratory_mucosa1.15617537
56MP0003436_decreased_susceptibility_to1.14667133
57MP0003724_increased_susceptibility_to1.14175171
58MP0009046_muscle_twitch1.11149241
59MP0002095_abnormal_skin_pigmentation1.09629832
60MP0010386_abnormal_urinary_bladder1.09532005
61MP0005410_abnormal_fertilization1.08917030
62MP0003866_abnormal_defecation1.07992398
63MP0009765_abnormal_xenobiotic_induced1.07129854
64MP0000631_abnormal_neuroendocrine_gland1.06822989
65MP0003806_abnormal_nucleotide_metabolis1.06754599
66MP0003186_abnormal_redox_activity1.05438353
67MP0006036_abnormal_mitochondrial_physio1.04230371
68MP0002452_abnormal_antigen_presenting1.03033921
69MP0001905_abnormal_dopamine_level1.02837485
70MP0003786_premature_aging1.01826863
71MP0005075_abnormal_melanosome_morpholog0.99095082
72MP0002420_abnormal_adaptive_immunity0.98856424
73MP0001873_stomach_inflammation0.98575106
74MP0005360_urolithiasis0.98254421
75MP0001819_abnormal_immune_cell0.97357034
76MP0001970_abnormal_pain_threshold0.96353661
77MP0005636_abnormal_mineral_homeostasis0.95451918
78MP0005379_endocrine/exocrine_gland_phen0.95274221
79MP0001502_abnormal_circadian_rhythm0.93508976
80MP0002138_abnormal_hepatobiliary_system0.93351585
81MP0002234_abnormal_pharynx_morphology0.91481382
82MP0004742_abnormal_vestibular_system0.88371685
83MP0008058_abnormal_DNA_repair0.88005834
84MP0001764_abnormal_homeostasis0.86716908
85MP0008775_abnormal_heart_ventricle0.84396048
86MP0001529_abnormal_vocalization0.84229809
87MP0010155_abnormal_intestine_physiology0.83275956
88MP0000230_abnormal_systemic_arterial0.82918580
89MP0001845_abnormal_inflammatory_respons0.80274639
90MP0009333_abnormal_splenocyte_physiolog0.77780863
91MP0003137_abnormal_impulse_conducting0.77779021
92MP0001963_abnormal_hearing_physiology0.77367663
93MP0003763_abnormal_thymus_physiology0.76976827
94MP0004043_abnormal_pH_regulation0.76392935
95MP0005025_abnormal_response_to0.76193148
96MP0005423_abnormal_somatic_nervous0.75778373
97MP0001485_abnormal_pinna_reflex0.75154408
98MP0002210_abnormal_sex_determination0.74897525
99MP0003718_maternal_effect0.74837944
100MP0001348_abnormal_lacrimal_gland0.74682612

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.46257096
2Mitochondrial inheritance (HP:0001427)3.92994489
3Abnormal mitochondria in muscle tissue (HP:0008316)3.87222769
4Acute encephalopathy (HP:0006846)3.81425267
5Lipid accumulation in hepatocytes (HP:0006561)3.78086466
6Progressive macrocephaly (HP:0004481)3.74215156
7IgG deficiency (HP:0004315)3.70479060
8Increased CSF lactate (HP:0002490)3.66138610
9Increased hepatocellular lipid droplets (HP:0006565)3.54243351
103-Methylglutaconic aciduria (HP:0003535)3.29393873
11Congenital stationary night blindness (HP:0007642)3.22547445
12Pancreatic cysts (HP:0001737)3.20964811
13Molar tooth sign on MRI (HP:0002419)3.16371339
14Abnormality of midbrain morphology (HP:0002418)3.16371339
15Hepatocellular necrosis (HP:0001404)3.00306289
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98721679
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98721679
18Reticulocytopenia (HP:0001896)2.92979340
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.91809107
20Stomatitis (HP:0010280)2.85991055
21Abnormality of cells of the erythroid lineage (HP:0012130)2.82935405
22Cerebral edema (HP:0002181)2.79959457
23Abnormal number of erythroid precursors (HP:0012131)2.76592776
24Congenital, generalized hypertrichosis (HP:0004540)2.75747056
25Hepatic necrosis (HP:0002605)2.75404269
26Abnormality of alanine metabolism (HP:0010916)2.73870699
27Hyperalaninemia (HP:0003348)2.73870699
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73870699
29Pancreatic fibrosis (HP:0100732)2.65931903
30Renal Fanconi syndrome (HP:0001994)2.62396218
31Macrocytic anemia (HP:0001972)2.59001629
32Nephronophthisis (HP:0000090)2.58718542
33Absent thumb (HP:0009777)2.55932496
34Abnormality of the renal cortex (HP:0011035)2.52920536
35Increased intramyocellular lipid droplets (HP:0012240)2.51574917
36Abolished electroretinogram (ERG) (HP:0000550)2.50762640
37Optic disc pallor (HP:0000543)2.50224697
38Exertional dyspnea (HP:0002875)2.46624318
39Increased muscle lipid content (HP:0009058)2.42631841
40Increased serum lactate (HP:0002151)2.40562353
41Methylmalonic acidemia (HP:0002912)2.38986216
42Lactic acidosis (HP:0003128)2.37527927
43Parakeratosis (HP:0001036)2.35442921
44Adrenal hypoplasia (HP:0000835)2.35359529
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34260291
46Aplasia/hypoplasia of the uterus (HP:0008684)2.31716935
47True hermaphroditism (HP:0010459)2.28954784
48Abnormality of the renal medulla (HP:0100957)2.26265222
49Elevated erythrocyte sedimentation rate (HP:0003565)2.24564910
50Methylmalonic aciduria (HP:0012120)2.21132316
51Pallor (HP:0000980)2.20513965
52Medial flaring of the eyebrow (HP:0010747)2.19405850
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16109631
54Colon cancer (HP:0003003)2.11474360
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10122093
56Respiratory failure (HP:0002878)2.08925864
57Leukodystrophy (HP:0002415)2.03300638
58Abnormal rod and cone electroretinograms (HP:0008323)2.02938692
59Type 2 muscle fiber atrophy (HP:0003554)2.02662861
60Hypoproteinemia (HP:0003075)2.00240391
61Type II lissencephaly (HP:0007260)1.98756562
62Polydipsia (HP:0001959)1.98451642
63Abnormal drinking behavior (HP:0030082)1.98451642
64Lethargy (HP:0001254)1.98118486
65Hypoplasia of the uterus (HP:0000013)1.97076789
66Pendular nystagmus (HP:0012043)1.95659965
67Attenuation of retinal blood vessels (HP:0007843)1.94616600
68Erythroderma (HP:0001019)1.93674253
69Aplasia/Hypoplasia of the spleen (HP:0010451)1.93613465
70Abnormality of urine glucose concentration (HP:0011016)1.93088246
71Glycosuria (HP:0003076)1.93088246
72Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91891436
73Abnormality of the ileum (HP:0001549)1.89629147
74Severe combined immunodeficiency (HP:0004430)1.88654618
75Decreased subcutaneous fat (HP:0001002)1.84897468
76Congenital ichthyosiform erythroderma (HP:0007431)1.84802566
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.84267713
78Abnormality of T cells (HP:0002843)1.83602894
79Hyperglycinemia (HP:0002154)1.83270825
80Renal cortical cysts (HP:0000803)1.80882168
81Testicular atrophy (HP:0000029)1.80752905
82Polyuria (HP:0000103)1.78747989
83Abnormality of renal resorption (HP:0011038)1.77402386
84Thyroiditis (HP:0100646)1.77173693
85Fragile nails (HP:0001808)1.75723830
86Sclerocornea (HP:0000647)1.75672899
87Large for gestational age (HP:0001520)1.75197373
88Exercise intolerance (HP:0003546)1.75110011
89Asplenia (HP:0001746)1.73324105
90Meckel diverticulum (HP:0002245)1.71460202
91Brittle hair (HP:0002299)1.70185922
92Tubular atrophy (HP:0000092)1.68643234
93Retrobulbar optic neuritis (HP:0100654)1.67813622
94Optic neuritis (HP:0100653)1.67813622
95Abnormality of serum amino acid levels (HP:0003112)1.67143350
96Decreased central vision (HP:0007663)1.66876060
97Respiratory difficulties (HP:0002880)1.66709541
98Abnormality of T cell physiology (HP:0011840)1.65491961
99Cerebral hypomyelination (HP:0006808)1.64939842
100Thyroid-stimulating hormone excess (HP:0002925)1.62571324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.88304166
2ADRBK23.38479813
3TXK3.01806389
4TLK12.93718667
5FRK2.68586585
6ZAK2.58593476
7GRK12.46424797
8NUAK12.33807791
9TAOK32.32251346
10BCKDK2.31627935
11WNK42.23857793
12TIE12.00226710
13TRIM281.94848281
14CDK191.93402836
15VRK21.89519561
16STK161.84343577
17WNK31.77236813
18PINK11.59645749
19FES1.55728114
20INSRR1.47306436
21ITK1.43200339
22TESK21.42791089
23MAP3K121.42625185
24TEC1.35487912
25MAP2K61.33455995
26DYRK21.31342017
27OXSR11.30489346
28NEK11.27654858
29EIF2AK31.20921918
30ADRBK11.20297049
31MAPKAPK31.19412605
32MAP3K41.15542746
33KIT1.05436398
34IKBKB1.04812762
35VRK11.03313293
36CSNK1G31.01794000
37STK391.01011692
38BMPR1B1.00370352
39KDR0.94139396
40CSNK1G20.91819891
41TSSK60.91239149
42MYLK0.91219062
43MAPK130.87773555
44PASK0.87145900
45CAMKK20.86297216
46MAP2K70.85097478
47IKBKE0.83879775
48GRK60.81651757
49RPS6KA50.80304295
50CSNK1G10.79921644
51NME10.79728081
52MAP2K20.77704534
53SRPK10.76265766
54PLK30.75707309
55CSNK1A1L0.74527952
56MST40.71622430
57MUSK0.69458700
58PHKG20.69026861
59PHKG10.69026861
60STK110.68309470
61GRK70.67029133
62PRKCG0.66831579
63SYK0.64260511
64MAP4K10.64207192
65DAPK10.63921032
66JAK30.63223757
67EIF2AK20.62849336
68GRK50.62335719
69MAPKAPK50.62108150
70BCR0.61936865
71PIK3CG0.60265200
72OBSCN0.58615569
73PIK3CA0.58414707
74PRKCQ0.57254471
75BUB10.56856248
76PRKCE0.56769829
77PLK40.54229804
78MKNK10.52797838
79LYN0.51343768
80PDK20.49997806
81PRKCA0.49547457
82CSNK1A10.47184201
83CSNK2A20.46644785
84PRKACA0.46633786
85CSNK2A10.46479648
86BTK0.44579853
87DAPK20.43731822
88BMPR20.43327358
89IGF1R0.40314061
90TAF10.40291162
91LCK0.39853400
92ERBB30.39295656
93CAMK2A0.38593914
94AURKB0.37689604
95PRKCD0.37538635
96CAMK2D0.37386883
97TNK20.37162739
98PRKCI0.36949711
99CHUK0.36231425
100MKNK20.35169354

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.98289657
2Oxidative phosphorylation_Homo sapiens_hsa001903.49428522
3Asthma_Homo sapiens_hsa053103.12120789
4Proteasome_Homo sapiens_hsa030503.05905560
5Parkinsons disease_Homo sapiens_hsa050122.78309852
6Protein export_Homo sapiens_hsa030602.63697024
7Allograft rejection_Homo sapiens_hsa053302.61163971
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.54757869
9Autoimmune thyroid disease_Homo sapiens_hsa053202.40625994
10Type I diabetes mellitus_Homo sapiens_hsa049402.24187537
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19152492
12Graft-versus-host disease_Homo sapiens_hsa053322.16484503
13RNA polymerase_Homo sapiens_hsa030202.07071080
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87798176
15Primary immunodeficiency_Homo sapiens_hsa053401.80693815
16Alzheimers disease_Homo sapiens_hsa050101.73459535
17Huntingtons disease_Homo sapiens_hsa050161.71173391
18Phototransduction_Homo sapiens_hsa047441.68759773
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61066441
20Basal transcription factors_Homo sapiens_hsa030221.59941479
21Rheumatoid arthritis_Homo sapiens_hsa053231.57862186
22One carbon pool by folate_Homo sapiens_hsa006701.54002906
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50557816
24Caffeine metabolism_Homo sapiens_hsa002321.50458849
25Cardiac muscle contraction_Homo sapiens_hsa042601.46200493
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46172848
27Homologous recombination_Homo sapiens_hsa034401.46021803
28Linoleic acid metabolism_Homo sapiens_hsa005911.41828588
29Nucleotide excision repair_Homo sapiens_hsa034201.32713596
30Mismatch repair_Homo sapiens_hsa034301.31569560
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31459489
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30784983
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23604212
34RNA degradation_Homo sapiens_hsa030181.20952429
35Pyrimidine metabolism_Homo sapiens_hsa002401.20816982
36Antigen processing and presentation_Homo sapiens_hsa046121.19417506
37Tryptophan metabolism_Homo sapiens_hsa003801.18921269
38Nitrogen metabolism_Homo sapiens_hsa009101.17748495
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14128260
40Fanconi anemia pathway_Homo sapiens_hsa034601.13823207
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11464023
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99857120
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98457875
44Collecting duct acid secretion_Homo sapiens_hsa049660.97626354
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97189784
46Peroxisome_Homo sapiens_hsa041460.96232558
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94117153
48Propanoate metabolism_Homo sapiens_hsa006400.91217454
49Hematopoietic cell lineage_Homo sapiens_hsa046400.90713025
50Purine metabolism_Homo sapiens_hsa002300.90365701
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89716714
52DNA replication_Homo sapiens_hsa030300.89017699
53Spliceosome_Homo sapiens_hsa030400.83729082
54Chemical carcinogenesis_Homo sapiens_hsa052040.80897934
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80597708
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.78943400
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.77861704
58Arachidonic acid metabolism_Homo sapiens_hsa005900.77399787
59Base excision repair_Homo sapiens_hsa034100.74041975
60RNA transport_Homo sapiens_hsa030130.72664807
61Nicotine addiction_Homo sapiens_hsa050330.69058840
62Butanoate metabolism_Homo sapiens_hsa006500.67662947
63Retinol metabolism_Homo sapiens_hsa008300.67566937
64Olfactory transduction_Homo sapiens_hsa047400.64042823
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63023675
66Ether lipid metabolism_Homo sapiens_hsa005650.62649237
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62194363
68Fat digestion and absorption_Homo sapiens_hsa049750.61393930
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61355872
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.60722094
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60701700
72Regulation of autophagy_Homo sapiens_hsa041400.59396257
73Metabolic pathways_Homo sapiens_hsa011000.58481298
74Morphine addiction_Homo sapiens_hsa050320.57628556
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.57503066
76Systemic lupus erythematosus_Homo sapiens_hsa053220.57056439
77Staphylococcus aureus infection_Homo sapiens_hsa051500.56580541
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55226254
79Viral myocarditis_Homo sapiens_hsa054160.54348027
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.52029139
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50451466
82Sulfur metabolism_Homo sapiens_hsa009200.50107720
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48262171
84Selenocompound metabolism_Homo sapiens_hsa004500.48128323
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48068710
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47198815
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.46361615
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42368075
89Steroid biosynthesis_Homo sapiens_hsa001000.42239823
90Taste transduction_Homo sapiens_hsa047420.39665652
91Leishmaniasis_Homo sapiens_hsa051400.38193033
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37244321
93ABC transporters_Homo sapiens_hsa020100.36314168
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34323669
95GABAergic synapse_Homo sapiens_hsa047270.32297745
96beta-Alanine metabolism_Homo sapiens_hsa004100.31634949
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.29408561
98Serotonergic synapse_Homo sapiens_hsa047260.26853833
99Pyruvate metabolism_Homo sapiens_hsa006200.26586059
100Herpes simplex infection_Homo sapiens_hsa051680.24009615

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