RPL15P20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.15697550
2cytidine deamination (GO:0009972)6.82791314
3cytidine metabolic process (GO:0046087)6.82791314
4cytidine catabolic process (GO:0006216)6.82791314
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.30020629
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.05161779
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.88110185
8ATP synthesis coupled proton transport (GO:0015986)4.88110185
9regulation of activation of Janus kinase activity (GO:0010533)4.74840697
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68981598
11ribosomal small subunit assembly (GO:0000028)4.59189729
12Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22481608
13actin nucleation (GO:0045010)3.94924396
14cellular response to interleukin-15 (GO:0071350)3.92758726
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87722457
16respiratory electron transport chain (GO:0022904)3.76689510
17electron transport chain (GO:0022900)3.74242801
18regulation of B cell receptor signaling pathway (GO:0050855)3.72144426
19protein neddylation (GO:0045116)3.71557616
20positive T cell selection (GO:0043368)3.63490337
21sequestering of actin monomers (GO:0042989)3.59315363
22positive regulation of defense response to virus by host (GO:0002230)3.55775248
23viral transcription (GO:0019083)3.54716585
24positive regulation of interleukin-8 secretion (GO:2000484)3.54073961
25protein complex biogenesis (GO:0070271)3.53991344
26negative regulation of mast cell activation (GO:0033004)3.52774194
27regulation of regulatory T cell differentiation (GO:0045589)3.51129700
28negative T cell selection (GO:0043383)3.49141830
29positive regulation of natural killer cell mediated immunity (GO:0002717)3.49082876
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.48976883
31positive thymic T cell selection (GO:0045059)3.48305877
32positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.47002907
33response to pheromone (GO:0019236)3.42743246
34translational termination (GO:0006415)3.40308444
35negative regulation of T cell apoptotic process (GO:0070233)3.40001736
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38161258
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28418734
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.28418734
39NADH dehydrogenase complex assembly (GO:0010257)3.28418734
40positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27429719
41positive regulation of calcium-mediated signaling (GO:0050850)3.24619552
42platelet dense granule organization (GO:0060155)3.24362109
43translational elongation (GO:0006414)3.23671622
44regulation of leukocyte mediated cytotoxicity (GO:0001910)3.23551176
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19948425
46positive regulation of cell killing (GO:0031343)3.19903939
47protein targeting to ER (GO:0045047)3.16554552
48regulation of natural killer cell mediated immunity (GO:0002715)3.14411930
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14411930
50cotranslational protein targeting to membrane (GO:0006613)3.13538983
51regulation of T cell receptor signaling pathway (GO:0050856)3.11485093
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.11428023
53mitochondrial respiratory chain complex assembly (GO:0033108)3.11237205
54cytolysis (GO:0019835)3.09808780
55pyrimidine nucleoside catabolic process (GO:0046135)3.08960657
56regulation of chronic inflammatory response (GO:0002676)3.08301333
57regulation of T cell mediated cytotoxicity (GO:0001914)3.05584295
58negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.05389441
59protein localization to endoplasmic reticulum (GO:0070972)3.04794197
60iron-sulfur cluster assembly (GO:0016226)3.03666640
61metallo-sulfur cluster assembly (GO:0031163)3.03666640
62T cell migration (GO:0072678)3.01486711
63regulation of cell killing (GO:0031341)2.99139589
64establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97522617
65regulation of interleukin-8 secretion (GO:2000482)2.97205180
66ribosomal small subunit biogenesis (GO:0042274)2.94185763
67negative regulation by host of viral transcription (GO:0043922)2.93301462
68response to interleukin-15 (GO:0070672)2.92253416
69mast cell activation (GO:0045576)2.86515141
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85845153
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85845153
72regulation of cellular amino acid metabolic process (GO:0006521)2.85581917
73maturation of SSU-rRNA (GO:0030490)2.85223636
74response to interferon-beta (GO:0035456)2.80714010
75positive regulation of T cell apoptotic process (GO:0070234)2.80304475
76positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.79638410
77negative regulation of viral genome replication (GO:0045071)2.79512157
78ATP biosynthetic process (GO:0006754)2.77704095
79establishment of protein localization to mitochondrial membrane (GO:0090151)2.76884704
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76784173
81hydrogen ion transmembrane transport (GO:1902600)2.75196227
82negative thymic T cell selection (GO:0045060)2.74100676
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70133424
84regulation of isotype switching to IgG isotypes (GO:0048302)2.69462310
85negative regulation of lymphocyte apoptotic process (GO:0070229)2.66633166
86DNA demethylation (GO:0080111)2.66133513
87proton transport (GO:0015992)2.62318360
88positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62031640
89thymic T cell selection (GO:0045061)2.61930387
90eosinophil chemotaxis (GO:0048245)2.60478865
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60385391
92positive regulation of B cell differentiation (GO:0045579)2.59704539
93DNA dealkylation (GO:0035510)2.58939799
94cytochrome complex assembly (GO:0017004)2.58746064
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.58337109
96viral life cycle (GO:0019058)2.57814634
97hydrogen transport (GO:0006818)2.57605952
98regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.57314156
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.56834086
100behavioral response to nicotine (GO:0035095)2.56737783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.50614846
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54682559
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35157613
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.21417942
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19585354
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.16722281
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96794132
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85481543
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.84524943
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77631814
11VDR_22108803_ChIP-Seq_LS180_Human2.61921232
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.56652378
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52826508
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50405705
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43800862
16EZH2_22144423_ChIP-Seq_EOC_Human2.41399953
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.13145322
18VDR_23849224_ChIP-Seq_CD4+_Human2.12712254
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04124014
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00456177
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00036036
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.89067373
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82237756
24FOXP3_21729870_ChIP-Seq_TREG_Human1.81846633
25ZNF274_21170338_ChIP-Seq_K562_Hela1.81450843
26MYB_26560356_Chip-Seq_TH2_Human1.76775057
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.68240697
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.65071621
29RUNX_20019798_ChIP-Seq_JUKART_Human1.58228395
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57301766
31GATA3_26560356_Chip-Seq_TH2_Human1.56311650
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55119740
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.52551158
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51738392
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50274210
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48822682
37NANOG_20526341_ChIP-Seq_ESCs_Human1.47595779
38GATA3_27048872_Chip-Seq_THYMUS_Human1.47012930
39IGF1R_20145208_ChIP-Seq_DFB_Human1.45457367
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45224723
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45174643
42TP53_22573176_ChIP-Seq_HFKS_Human1.43411804
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40639373
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40241489
45TAF2_19829295_ChIP-Seq_ESCs_Human1.39771705
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37542925
47MYC_18940864_ChIP-ChIP_HL60_Human1.36894376
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.35813255
49AR_20517297_ChIP-Seq_VCAP_Human1.35733119
50ELK1_19687146_ChIP-ChIP_HELA_Human1.34330734
51BCL6_27268052_Chip-Seq_Bcells_Human1.34140095
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29569344
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.27533274
54NCOR_22424771_ChIP-Seq_293T_Human1.21568863
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.21245073
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21245073
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20817990
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20468094
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16822078
60CTCF_20526341_ChIP-Seq_ESCs_Human1.15585942
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15520890
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.15232737
63HTT_18923047_ChIP-ChIP_STHdh_Human1.14794824
64MYC_19829295_ChIP-Seq_ESCs_Human1.12567386
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.09738212
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09296244
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08308472
68P300_27268052_Chip-Seq_Bcells_Human1.08090682
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06513678
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04899069
71ERA_21632823_ChIP-Seq_H3396_Human1.04807024
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04803683
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04487851
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04189724
75MYB_26560356_Chip-Seq_TH1_Human1.03734011
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02918043
77UTX_26944678_Chip-Seq_JUKART_Human1.02476518
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01848018
79IRF1_19129219_ChIP-ChIP_H3396_Human1.00914769
80ERG_20517297_ChIP-Seq_VCAP_Human1.00644867
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99919206
82CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99708083
83STAT1_20625510_ChIP-Seq_HELA_Human0.99620612
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99531586
85E2F1_20622854_ChIP-Seq_HELA_Human0.99052396
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98574965
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.97723078
88P53_21459846_ChIP-Seq_SAOS-2_Human0.95642170
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95495374
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.94358926
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93838270
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.93807554
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93778092
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93538155
95SOX2_19829295_ChIP-Seq_ESCs_Human0.92998528
96NANOG_19829295_ChIP-Seq_ESCs_Human0.92998528
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92633192
98SA1_27219007_Chip-Seq_Bcells_Human0.92478355
99MAF_26560356_Chip-Seq_TH2_Human0.91397048
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90554398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.35269225
2MP0009785_altered_susceptibility_to2.89456600
3MP0001835_abnormal_antigen_presentation2.80413863
4MP0003763_abnormal_thymus_physiology2.60881239
5MP0009379_abnormal_foot_pigmentation2.57818506
6MP0009333_abnormal_splenocyte_physiolog2.30809690
7MP0005646_abnormal_pituitary_gland2.18215200
8MP0005000_abnormal_immune_tolerance2.08483228
9MP0001800_abnormal_humoral_immune2.06421082
10MP0005377_hearing/vestibular/ear_phenot2.02044830
11MP0003878_abnormal_ear_physiology2.02044830
12MP0003646_muscle_fatigue1.96542914
13MP0002148_abnormal_hypersensitivity_rea1.91839084
14MP0001873_stomach_inflammation1.88818750
15MP0002723_abnormal_immune_serum1.86454569
16MP0002102_abnormal_ear_morphology1.86004147
17MP0006292_abnormal_olfactory_placode1.83269883
18MP0005025_abnormal_response_to1.83061496
19MP0002420_abnormal_adaptive_immunity1.82580227
20MP0006072_abnormal_retinal_apoptosis1.81902734
21MP0005645_abnormal_hypothalamus_physiol1.79548916
22MP0004147_increased_porphyrin_level1.79331239
23MP0001790_abnormal_immune_system1.77239463
24MP0005387_immune_system_phenotype1.77239463
25MP0001819_abnormal_immune_cell1.77028528
26MP0002837_dystrophic_cardiac_calcinosis1.73580588
27MP0005551_abnormal_eye_electrophysiolog1.66037929
28MP0000372_irregular_coat_pigmentation1.65694669
29MP0005075_abnormal_melanosome_morpholog1.65603896
30MP0000685_abnormal_immune_system1.64001340
31MP0003866_abnormal_defecation1.62880874
32MP0002166_altered_tumor_susceptibility1.60368849
33MP0002163_abnormal_gland_morphology1.60042165
34MP0008872_abnormal_physiological_respon1.59898689
35MP0002876_abnormal_thyroid_physiology1.58428489
36MP0002452_abnormal_antigen_presenting1.51978830
37MP0003011_delayed_dark_adaptation1.46100302
38MP0004145_abnormal_muscle_electrophysio1.44127273
39MP0003786_premature_aging1.42522302
40MP0002006_tumorigenesis1.40083694
41MP0008875_abnormal_xenobiotic_pharmacok1.39687798
42MP0000716_abnormal_immune_system1.38618678
43MP0001968_abnormal_touch/_nociception1.37577085
44MP0008789_abnormal_olfactory_epithelium1.36087400
45MP0001905_abnormal_dopamine_level1.35361990
46MP0002736_abnormal_nociception_after1.34229842
47MP0002398_abnormal_bone_marrow1.33152153
48MP0003787_abnormal_imprinting1.33010210
49MP0002933_joint_inflammation1.32742257
50MP0001919_abnormal_reproductive_system1.32334997
51MP0006036_abnormal_mitochondrial_physio1.30189292
52MP0001986_abnormal_taste_sensitivity1.29774626
53MP0006082_CNS_inflammation1.27324613
54MP0002405_respiratory_system_inflammati1.26665128
55MP0008877_abnormal_DNA_methylation1.26405702
56MP0005379_endocrine/exocrine_gland_phen1.25949603
57MP0002638_abnormal_pupillary_reflex1.22645318
58MP0002095_abnormal_skin_pigmentation1.21424038
59MP0000689_abnormal_spleen_morphology1.20842495
60MP0005253_abnormal_eye_physiology1.18417626
61MP0005389_reproductive_system_phenotype1.17201985
62MP0001845_abnormal_inflammatory_respons1.17173529
63MP0010155_abnormal_intestine_physiology1.16822421
64MP0000703_abnormal_thymus_morphology1.15900567
65MP0004885_abnormal_endolymph1.13327967
66MP0001485_abnormal_pinna_reflex1.12268449
67MP0002722_abnormal_immune_system1.10498518
68MP0002429_abnormal_blood_cell1.07145892
69MP0001853_heart_inflammation1.04003580
70MP0003195_calcinosis1.00150614
71MP0003436_decreased_susceptibility_to0.99578750
72MP0009764_decreased_sensitivity_to0.98446461
73MP0005410_abnormal_fertilization0.97870005
74MP0002419_abnormal_innate_immunity0.94988654
75MP0005174_abnormal_tail_pigmentation0.91472828
76MP0002277_abnormal_respiratory_mucosa0.91326831
77MP0001765_abnormal_ion_homeostasis0.91085089
78MP0008469_abnormal_protein_level0.89198035
79MP0005636_abnormal_mineral_homeostasis0.89191874
80MP0002693_abnormal_pancreas_physiology0.85224067
81MP0004142_abnormal_muscle_tone0.85171290
82MP0002272_abnormal_nervous_system0.83186790
83MP0009745_abnormal_behavioral_response0.83002391
84MP0010386_abnormal_urinary_bladder0.82430388
85MP0001501_abnormal_sleep_pattern0.82039744
86MP0001984_abnormal_olfaction0.81427089
87MP0004742_abnormal_vestibular_system0.79079672
88MP0006276_abnormal_autonomic_nervous0.79007404
89MP0008995_early_reproductive_senescence0.76655535
90MP0002653_abnormal_ependyma_morphology0.76622954
91MP0002160_abnormal_reproductive_system0.76456020
92MP0002234_abnormal_pharynx_morphology0.75933432
93MP0001188_hyperpigmentation0.75691906
94MP0003806_abnormal_nucleotide_metabolis0.74000375
95MP0001348_abnormal_lacrimal_gland0.73768596
96MP0001764_abnormal_homeostasis0.73538499
97MP0005394_taste/olfaction_phenotype0.71166583
98MP0005499_abnormal_olfactory_system0.71166583
99MP0002138_abnormal_hepatobiliary_system0.70061908
100MP0001119_abnormal_female_reproductive0.69621785

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.09713321
23-Methylglutaconic aciduria (HP:0003535)4.07702271
3Acute necrotizing encephalopathy (HP:0006965)4.06915262
4Aplastic anemia (HP:0001915)4.06781556
5Mitochondrial inheritance (HP:0001427)3.95181400
6IgG deficiency (HP:0004315)3.94469570
7T lymphocytopenia (HP:0005403)3.93753088
8Abnormality of T cell number (HP:0011839)3.84783906
9Severe combined immunodeficiency (HP:0004430)3.81147763
10Abnormal mitochondria in muscle tissue (HP:0008316)3.80966535
11Elevated erythrocyte sedimentation rate (HP:0003565)3.60582102
12Acute encephalopathy (HP:0006846)3.44096787
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.43260556
14Increased CSF lactate (HP:0002490)3.35601707
15Increased intramyocellular lipid droplets (HP:0012240)3.26077004
16Autoimmune hemolytic anemia (HP:0001890)3.23961202
17Progressive macrocephaly (HP:0004481)3.23160119
18Hypoproteinemia (HP:0003075)3.16841417
19Hepatocellular necrosis (HP:0001404)3.11266876
20Pancreatic cysts (HP:0001737)3.04983313
21Renal cortical cysts (HP:0000803)3.02132223
22Increased hepatocellular lipid droplets (HP:0006565)3.00794279
23Abnormality of T cells (HP:0002843)3.00389593
24Abnormal rod and cone electroretinograms (HP:0008323)2.98034896
25Increased IgM level (HP:0003496)2.88587681
26Combined immunodeficiency (HP:0005387)2.87400295
27Abnormality of B cell number (HP:0010975)2.85574257
28Hepatic necrosis (HP:0002605)2.84619158
29Renal Fanconi syndrome (HP:0001994)2.83473035
30Thyroiditis (HP:0100646)2.81097080
31Abnormality of midbrain morphology (HP:0002418)2.74469834
32Molar tooth sign on MRI (HP:0002419)2.74469834
33Stomatitis (HP:0010280)2.73356429
34Abnormality of the renal cortex (HP:0011035)2.72689749
35Lipid accumulation in hepatocytes (HP:0006561)2.67922794
36Increased muscle lipid content (HP:0009058)2.66462189
37Cerebral edema (HP:0002181)2.64779907
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62853853
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62853853
40Pancreatic fibrosis (HP:0100732)2.60483901
41Abnormality of eosinophils (HP:0001879)2.60067837
42Abnormality of the prostate (HP:0008775)2.56461592
43Abnormality of cells of the erythroid lineage (HP:0012130)2.55650224
44Pancytopenia (HP:0001876)2.53254908
45Abolished electroretinogram (ERG) (HP:0000550)2.53054258
46Abnormal number of erythroid precursors (HP:0012131)2.52797016
47Severe visual impairment (HP:0001141)2.47522202
48Reticulocytopenia (HP:0001896)2.46351243
49Optic disc pallor (HP:0000543)2.45340165
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43715572
51B lymphocytopenia (HP:0010976)2.34687025
52True hermaphroditism (HP:0010459)2.32582249
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31661008
54Attenuation of retinal blood vessels (HP:0007843)2.30645607
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25127386
56Increased serum lactate (HP:0002151)2.22484178
57Chronic diarrhea (HP:0002028)2.22007241
58Lactic acidosis (HP:0003128)2.19138562
59Exertional dyspnea (HP:0002875)2.15740038
60Asplenia (HP:0001746)2.06191975
61Generalized aminoaciduria (HP:0002909)2.03206259
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.02883211
63Nephronophthisis (HP:0000090)2.00416139
64Polydipsia (HP:0001959)1.99147332
65Abnormal drinking behavior (HP:0030082)1.99147332
66Pendular nystagmus (HP:0012043)1.96568962
67Recurrent bronchitis (HP:0002837)1.96368995
68Macrocytic anemia (HP:0001972)1.96331587
69Encephalitis (HP:0002383)1.94035887
70Abnormal delayed hypersensitivity skin test (HP:0002963)1.94004962
71Methylmalonic acidemia (HP:0002912)1.93579356
72Exercise intolerance (HP:0003546)1.93241620
73Absent thumb (HP:0009777)1.93238752
74Lethargy (HP:0001254)1.89131961
75Lymphopenia (HP:0001888)1.89016624
76Decreased central vision (HP:0007663)1.87957145
77Abnormality of T cell physiology (HP:0011840)1.87711155
78Autoimmune thrombocytopenia (HP:0001973)1.85951145
79Leukocytosis (HP:0001974)1.85374407
80Methylmalonic aciduria (HP:0012120)1.84663132
81Constricted visual fields (HP:0001133)1.84225720
82Respiratory failure (HP:0002878)1.82960989
83Eosinophilia (HP:0001880)1.82935829
84Congenital, generalized hypertrichosis (HP:0004540)1.82521148
85Oral leukoplakia (HP:0002745)1.82184555
86Microretrognathia (HP:0000308)1.81946448
87Medial flaring of the eyebrow (HP:0010747)1.78759774
88Type I transferrin isoform profile (HP:0003642)1.78489565
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.77027272
90Abnormality of urine glucose concentration (HP:0011016)1.76814504
91Glycosuria (HP:0003076)1.76814504
92Chronic mucocutaneous candidiasis (HP:0002728)1.75303717
93Recurrent cutaneous fungal infections (HP:0011370)1.75303717
94Abnormal albumin level (HP:0012116)1.74932122
95Hypoalbuminemia (HP:0003073)1.74932122
96Agammaglobulinemia (HP:0004432)1.74110702
97Dicarboxylic aciduria (HP:0003215)1.73685976
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73685976
99Cerebral palsy (HP:0100021)1.73116250
100Abnormal biliary tract physiology (HP:0012439)1.72489801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.23338078
2KDR4.58855428
3TESK24.13189443
4BCKDK2.81207687
5MAP4K12.59528141
6ADRBK22.57290560
7ZAK2.45110362
8LIMK12.34622817
9GRK12.14438213
10VRK22.05365421
11MAP4K22.05117370
12MUSK2.03509591
13TLK12.03398409
14ITK1.90371559
15TAOK31.87824919
16FES1.80619960
17STK161.61350125
18NUAK11.53694057
19VRK11.42056218
20PINK11.32237569
21TIE11.28996874
22GRK61.28759203
23MAP3K111.28324406
24SYK1.27186742
25CAMKK21.26542020
26WNK41.26235669
27PASK1.25044641
28MAP3K121.24001465
29CDK191.19553026
30MST41.16138143
31TEC1.15839087
32SCYL21.15445580
33PRKCQ1.13764702
34TNK21.09456751
35IKBKE1.07022803
36TESK11.06591132
37GRK71.03740554
38LCK1.03725201
39IKBKB1.03202239
40BMPR1B1.00985226
41INSRR0.97574611
42BTK0.96217428
43BUB10.88041507
44KIT0.86926474
45ZAP700.85080178
46LYN0.84390943
47CAMKK10.82984243
48DAPK10.81320887
49NME10.79561782
50PIK3CA0.78950039
51CDK80.77913312
52DYRK20.75541333
53FRK0.72370145
54RPS6KA50.71760617
55MAP2K70.70067599
56MYLK0.69591897
57PIM20.69383514
58CSK0.68909314
59WNK30.68149490
60MAPKAPK30.65621690
61CSF1R0.63884062
62ADRBK10.62244809
63TBK10.59946534
64PIM10.59359229
65DAPK20.58628723
66IGF1R0.57966508
67MATK0.54610111
68MAP2K60.54466882
69OBSCN0.54301245
70PIK3CG0.52271528
71OXSR10.50988798
72AURKA0.47277672
73PRKCA0.43853563
74PRKACA0.43788355
75JAK30.42896345
76CAMK10.42332014
77LRRK20.41870069
78MAPK130.40615697
79FYN0.40154267
80ILK0.37031642
81NEK10.36218384
82RPS6KA40.34093379
83CSNK2A10.34067080
84GRK50.33153042
85CSNK2A20.32173652
86EIF2AK30.31871592
87RIPK40.31472990
88ROCK10.31039496
89ATR0.30303095
90INSR0.29853153
91PRKCD0.29839421
92BMPR20.29741718
93CSNK1G30.28043723
94DAPK30.27579881
95PLK40.26828235
96PRKCG0.26736088
97BRSK10.26542861
98MAPKAPK50.26201759
99CAMK2A0.25868061
100PAK10.25159914

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.50811572
2Oxidative phosphorylation_Homo sapiens_hsa001903.90348385
3Proteasome_Homo sapiens_hsa030503.90029412
4Ribosome_Homo sapiens_hsa030103.64395671
5Parkinsons disease_Homo sapiens_hsa050123.34526737
6Graft-versus-host disease_Homo sapiens_hsa053322.49483904
7Autoimmune thyroid disease_Homo sapiens_hsa053202.39506225
8Allograft rejection_Homo sapiens_hsa053302.31972828
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20045374
10Alzheimers disease_Homo sapiens_hsa050102.15561959
11RNA polymerase_Homo sapiens_hsa030202.13427261
12Antigen processing and presentation_Homo sapiens_hsa046122.10253628
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06875495
14Huntingtons disease_Homo sapiens_hsa050162.01980354
15Hematopoietic cell lineage_Homo sapiens_hsa046401.97284880
16Type I diabetes mellitus_Homo sapiens_hsa049401.93777138
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92617821
18Cardiac muscle contraction_Homo sapiens_hsa042601.90413412
19Protein export_Homo sapiens_hsa030601.84163866
20Phototransduction_Homo sapiens_hsa047441.76779984
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69463616
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.54179706
23Asthma_Homo sapiens_hsa053101.45506745
24T cell receptor signaling pathway_Homo sapiens_hsa046601.43518933
25Homologous recombination_Homo sapiens_hsa034401.42083939
26Linoleic acid metabolism_Homo sapiens_hsa005911.35853851
27Rheumatoid arthritis_Homo sapiens_hsa053231.33659875
28Caffeine metabolism_Homo sapiens_hsa002321.28654511
29Nitrogen metabolism_Homo sapiens_hsa009101.26889406
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20016099
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19494943
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19300120
33Pyrimidine metabolism_Homo sapiens_hsa002401.14646556
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13484983
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13030767
36One carbon pool by folate_Homo sapiens_hsa006701.12709039
37RNA degradation_Homo sapiens_hsa030181.08144697
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02126466
39Peroxisome_Homo sapiens_hsa041460.97835172
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89312820
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82715440
42Purine metabolism_Homo sapiens_hsa002300.82534036
43Fanconi anemia pathway_Homo sapiens_hsa034600.81617086
44DNA replication_Homo sapiens_hsa030300.79816260
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79589717
46Measles_Homo sapiens_hsa051620.78498142
47Retinol metabolism_Homo sapiens_hsa008300.78223364
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.77812242
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.75749625
50Arachidonic acid metabolism_Homo sapiens_hsa005900.75192683
51Olfactory transduction_Homo sapiens_hsa047400.74329458
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72219318
53Chemical carcinogenesis_Homo sapiens_hsa052040.69456835
54Tryptophan metabolism_Homo sapiens_hsa003800.68265271
55Viral myocarditis_Homo sapiens_hsa054160.67609970
56Propanoate metabolism_Homo sapiens_hsa006400.67082880
57Butanoate metabolism_Homo sapiens_hsa006500.66073460
58Mismatch repair_Homo sapiens_hsa034300.65416221
59Malaria_Homo sapiens_hsa051440.64811879
60Regulation of autophagy_Homo sapiens_hsa041400.64523209
61Nucleotide excision repair_Homo sapiens_hsa034200.61600565
62Sulfur metabolism_Homo sapiens_hsa009200.61068463
63Basal transcription factors_Homo sapiens_hsa030220.60466740
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.57363467
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.56173409
66Systemic lupus erythematosus_Homo sapiens_hsa053220.55977807
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55673073
68Spliceosome_Homo sapiens_hsa030400.55214368
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55209028
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54308251
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53772846
72Metabolic pathways_Homo sapiens_hsa011000.52849999
73Selenocompound metabolism_Homo sapiens_hsa004500.51840143
74Ether lipid metabolism_Homo sapiens_hsa005650.50627947
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49788195
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49775741
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49320758
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.49160875
79Collecting duct acid secretion_Homo sapiens_hsa049660.49110562
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48740146
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47558737
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44804642
83Base excision repair_Homo sapiens_hsa034100.44292200
84Sulfur relay system_Homo sapiens_hsa041220.41223699
85Taste transduction_Homo sapiens_hsa047420.41023636
86Fat digestion and absorption_Homo sapiens_hsa049750.37617445
87Salmonella infection_Homo sapiens_hsa051320.33838236
88Nicotine addiction_Homo sapiens_hsa050330.32733576
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31792568
90Morphine addiction_Homo sapiens_hsa050320.30188214
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.29797887
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29377113
93Shigellosis_Homo sapiens_hsa051310.26241658
94Herpes simplex infection_Homo sapiens_hsa051680.25008710
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24671828
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.21443206
97Ovarian steroidogenesis_Homo sapiens_hsa049130.19655593
98Mineral absorption_Homo sapiens_hsa049780.19577510
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18944595
100Tyrosine metabolism_Homo sapiens_hsa003500.18649854

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