ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.35588884
2	ATP synthesis coupled proton transport (GO:0015986)	7.79308422
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.79308422
4	viral transcription (GO:0019083)	7.33428168
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.32802511
6	translational termination (GO:0006415)	7.01215474
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.15289059
8	ribosomal small subunit assembly (GO:0000028)	6.15183257
9	translational elongation (GO:0006414)	6.13584604
10	cotranslational protein targeting to membrane (GO:0006613)	6.05490531
11	protein targeting to ER (GO:0045047)	6.05406110
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.75146365
13	GTP biosynthetic process (GO:0006183)	5.72736901
14	protein localization to endoplasmic reticulum (GO:0070972)	5.69344474
15	maturation of SSU-rRNA (GO:0030490)	5.54538974
16	cellular protein complex disassembly (GO:0043624)	5.39498937
17	viral life cycle (GO:0019058)	5.28444380
18	DNA deamination (GO:0045006)	5.22735336
19	chaperone-mediated protein transport (GO:0072321)	5.20558327
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.17789427
21	ribosomal large subunit biogenesis (GO:0042273)	5.16552295
22	respiratory electron transport chain (GO:0022904)	5.14923926
23	electron transport chain (GO:0022900)	5.10851415
24	UTP biosynthetic process (GO:0006228)	5.09451454
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.94867401
26	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.89265723
27	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.87561520
28	translational initiation (GO:0006413)	4.83979202
29	protein complex biogenesis (GO:0070271)	4.79959771
30	UTP metabolic process (GO:0046051)	4.69038580
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.65518908
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.65518908
33	NADH dehydrogenase complex assembly (GO:0010257)	4.65518908
34	ATP biosynthetic process (GO:0006754)	4.62906404
35	translation (GO:0006412)	4.57483223
36	protein complex disassembly (GO:0043241)	4.52443757
37	maturation of 5.8S rRNA (GO:0000460)	4.48961860
38	mitochondrial respiratory chain complex assembly (GO:0033108)	4.48801751
39	signal peptide processing (GO:0006465)	4.45030501
40	negative regulation of mast cell activation (GO:0033004)	4.42868014
41	ribonucleoside triphosphate biosynthetic process (GO:0009201)	4.35756048
42	macromolecular complex disassembly (GO:0032984)	4.22186738
43	protein neddylation (GO:0045116)	4.17380136
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.16730301
45	CTP metabolic process (GO:0046036)	4.15404074
46	CTP biosynthetic process (GO:0006241)	4.15404074
47	respiratory chain complex IV assembly (GO:0008535)	4.12918729
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.10215716
49	ribonucleoprotein complex biogenesis (GO:0022613)	4.09417793
50	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.04098510
51	cellular component biogenesis (GO:0044085)	4.01091701
52	guanosine-containing compound biosynthetic process (GO:1901070)	3.97791416
53	peptidyl-histidine modification (GO:0018202)	3.95998900
54	protein targeting to membrane (GO:0006612)	3.95859325
55	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.94202328
56	cytochrome complex assembly (GO:0017004)	3.90462279
57	nucleoside triphosphate biosynthetic process (GO:0009142)	3.82663859
58	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.78438631
59	rRNA modification (GO:0000154)	3.74763110
60	mRNA catabolic process (GO:0006402)	3.68818716
61	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.63738133
62	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.63310100
63	hydrogen ion transmembrane transport (GO:1902600)	3.60361592
64	oxidative phosphorylation (GO:0006119)	3.60292439
65	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.55556135
66	nucleoside diphosphate phosphorylation (GO:0006165)	3.54415491
67	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.50292917
68	rRNA processing (GO:0006364)	3.44360868
69	RNA catabolic process (GO:0006401)	3.36990387
70	rRNA metabolic process (GO:0016072)	3.33281639
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.23022724
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.23022724
73	mitochondrion transport along microtubule (GO:0047497)	3.22772871
74	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.22772871
75	proton transport (GO:0015992)	3.20922372
76	water-soluble vitamin biosynthetic process (GO:0042364)	3.20591797
77	protein targeting to mitochondrion (GO:0006626)	3.18785040
78	behavioral response to nicotine (GO:0035095)	3.17972398
79	prenylation (GO:0097354)	3.14240704
80	protein prenylation (GO:0018342)	3.14240704
81	hydrogen transport (GO:0006818)	3.13319459
82	pseudouridine synthesis (GO:0001522)	3.12150977
83	pyrimidine nucleotide catabolic process (GO:0006244)	3.09941089
84	establishment of mitochondrion localization (GO:0051654)	3.06913409
85	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04161241
86	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.01949938
87	cardiovascular system development (GO:0072358)	2.99368476
88	establishment of protein localization to mitochondrion (GO:0072655)	2.98987753
89	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.94546310
90	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.94546310
91	rRNA methylation (GO:0031167)	2.91479257
92	negative regulation of phagocytosis (GO:0050765)	2.91075079
93	termination of RNA polymerase III transcription (GO:0006386)	2.90140514
94	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.90140514
95	base-excision repair, AP site formation (GO:0006285)	2.89761722
96	intracellular protein transmembrane import (GO:0044743)	2.86349832
97	proteasome assembly (GO:0043248)	2.85539066
98	protein localization to mitochondrion (GO:0070585)	2.82709288
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82629001
100	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.81567023

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.12453487
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.81523561
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.83195654
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.65412896
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.64588739
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.56768216
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.36532490
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.31550901
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.96824926
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.95047146
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.81246365
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.68537617
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.58439742
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.38574914
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.29197761
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.27952764
17	VDR_22108803_ChIP-Seq_LS180_Human	2.20356694
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19931601
19	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.19204245
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.17004193
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.10975419
22	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.09976004
23	XRN2_22483619_ChIP-Seq_HELA_Human	2.05975268
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99581748
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.91173689
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87345411
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.77004445
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72820835
29	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.64986014
30	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.63550465
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60818282
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.59364946
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.57323588
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.53310144
35	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.48493632
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44104679
37	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.41564476
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38615515
39	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.32027168
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.31931488
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.30327581
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29115436
43	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.28570704
44	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28520238
45	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.27841554
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27279140
47	BCL6_27268052_Chip-Seq_Bcells_Human	1.26722459
48	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.25933276
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.22536490
50	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.20699422
51	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.18311594
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15695585
53	ERA_21632823_ChIP-Seq_H3396_Human	1.15236915
54	CTCF_20526341_ChIP-Seq_ESCs_Human	1.14814685
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14287761
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13273228
57	STAT1_20625510_ChIP-Seq_HELA_Human	1.11200806
58	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09020624
59	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06171714
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05127414
61	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.04176142
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03986909
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.03578904
64	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.03310417
65	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02982204
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02853875
67	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02417062
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01998453
69	EWS_26573619_Chip-Seq_HEK293_Human	1.01975432
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00615511
71	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00502445
72	SA1_27219007_Chip-Seq_Bcells_Human	0.99661993
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99250461
74	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98806452
75	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97796328
76	TP53_22573176_ChIP-Seq_HFKS_Human	0.96800496
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.96537936
78	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96393532
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95756486
80	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.94980914
81	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.92393231
82	E2F1_20622854_ChIP-Seq_HELA_Human	0.91575675
83	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.91192136
84	KDM5A_27292631_Chip-Seq_BREAST_Human	0.90704790
85	AR_20517297_ChIP-Seq_VCAP_Human	0.89995016
86	NCOR_22424771_ChIP-Seq_293T_Human	0.89074488
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.88742735
88	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87421233
89	REST_21632747_ChIP-Seq_MESCs_Mouse	0.87217844
90	CTCF_27219007_Chip-Seq_Bcells_Human	0.86807318
91	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.86620460
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.86420734
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.86420734
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.85682049
95	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.84159402
96	P300_27268052_Chip-Seq_Bcells_Human	0.84028468
97	SOX2_21211035_ChIP-Seq_LN229_Human	0.83519630
98	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.82980563
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.82750965
100	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.82216408

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.35919623
2	MP0003646_muscle_fatigue	4.32873438
3	MP0006292_abnormal_olfactory_placode	4.05867347
4	MP0005646_abnormal_pituitary_gland	2.98095125
5	MP0004145_abnormal_muscle_electrophysio	2.91987666
6	MP0004858_abnormal_nervous_system	2.44013985
7	MP0008877_abnormal_DNA_methylation	2.43271535
8	MP0002163_abnormal_gland_morphology	2.12610552
9	MP0003787_abnormal_imprinting	2.07022878
10	MP0008875_abnormal_xenobiotic_pharmacok	2.03140446
11	MP0003123_paternal_imprinting	2.02466636
12	MP0005645_abnormal_hypothalamus_physiol	1.99017575
13	MP0008789_abnormal_olfactory_epithelium	1.94589583
14	MP0003122_maternal_imprinting	1.88516041
15	MP0003121_genomic_imprinting	1.82409525
16	MP0004147_increased_porphyrin_level	1.80466044
17	MP0003693_abnormal_embryo_hatching	1.79798810
18	MP0004142_abnormal_muscle_tone	1.70333476
19	MP0008058_abnormal_DNA_repair	1.69632086
20	MP0004885_abnormal_endolymph	1.65503483
21	MP0000049_abnormal_middle_ear	1.64414832
22	MP0003011_delayed_dark_adaptation	1.61437255
23	MP0002160_abnormal_reproductive_system	1.54997074
24	MP0005389_reproductive_system_phenotype	1.53747351
25	MP0006036_abnormal_mitochondrial_physio	1.51118633
26	MP0002736_abnormal_nociception_after	1.48676074
27	MP0004742_abnormal_vestibular_system	1.46659657
28	MP0005394_taste/olfaction_phenotype	1.44056061
29	MP0005499_abnormal_olfactory_system	1.44056061
30	MP0001919_abnormal_reproductive_system	1.42808553
31	MP0008872_abnormal_physiological_respon	1.42009585
32	MP0006276_abnormal_autonomic_nervous	1.41785366
33	MP0001968_abnormal_touch/_nociception	1.37121946
34	MP0001485_abnormal_pinna_reflex	1.35073805
35	MP0002876_abnormal_thyroid_physiology	1.33974769
36	MP0003186_abnormal_redox_activity	1.33732014
37	MP0000685_abnormal_immune_system	1.30690253
38	MP0005551_abnormal_eye_electrophysiolog	1.30650661
39	MP0001348_abnormal_lacrimal_gland	1.27771849
40	MP0008775_abnormal_heart_ventricle	1.27608463
41	MP0000631_abnormal_neuroendocrine_gland	1.25309921
42	MP0002234_abnormal_pharynx_morphology	1.19590004
43	MP0002938_white_spotting	1.17269007
44	MP0001529_abnormal_vocalization	1.15535843
45	MP0009046_muscle_twitch	1.13767428
46	MP0001905_abnormal_dopamine_level	1.11475539
47	MP0002095_abnormal_skin_pigmentation	1.09424289
48	MP0000566_synostosis	1.08370701
49	MP0003195_calcinosis	1.08342373
50	MP0004043_abnormal_pH_regulation	1.07754795
51	MP0005397_hematopoietic_system_phenotyp	1.05666233
52	MP0001545_abnormal_hematopoietic_system	1.05666233
53	MP0005408_hypopigmentation	1.02433363
54	MP0005379_endocrine/exocrine_gland_phen	1.01801466
55	MP0002102_abnormal_ear_morphology	1.01783772
56	MP0001986_abnormal_taste_sensitivity	1.00966304
57	MP0002837_dystrophic_cardiac_calcinosis	0.99807051
58	MP0003315_abnormal_perineum_morphology	0.98859591
59	MP0004133_heterotaxia	0.98683822
60	MP0009745_abnormal_behavioral_response	0.93486353
61	MP0005195_abnormal_posterior_eye	0.89508303
62	MP0006072_abnormal_retinal_apoptosis	0.88916317
63	MP0002184_abnormal_innervation	0.86412952
64	MP0003119_abnormal_digestive_system	0.85615861
65	MP0003879_abnormal_hair_cell	0.85410521
66	MP0003786_premature_aging	0.84527400
67	MP0003718_maternal_effect	0.83083012
68	MP0002272_abnormal_nervous_system	0.81709147
69	MP0000372_irregular_coat_pigmentation	0.81099595
70	MP0002210_abnormal_sex_determination	0.79243628
71	MP0001293_anophthalmia	0.79173365
72	MP0000026_abnormal_inner_ear	0.78188151
73	MP0003806_abnormal_nucleotide_metabolis	0.78061398
74	MP0000678_abnormal_parathyroid_gland	0.77017449
75	MP0002277_abnormal_respiratory_mucosa	0.76296592
76	MP0001963_abnormal_hearing_physiology	0.75722989
77	MP0002752_abnormal_somatic_nervous	0.74639698
78	MP0001663_abnormal_digestive_system	0.74333562
79	MP0003938_abnormal_ear_development	0.72086195
80	MP0005167_abnormal_blood-brain_barrier	0.70821387
81	MP0005636_abnormal_mineral_homeostasis	0.70232193
82	MP0009764_decreased_sensitivity_to	0.69889718
83	MP0001970_abnormal_pain_threshold	0.69852515
84	MP0002733_abnormal_thermal_nociception	0.69597396
85	MP0009250_abnormal_appendicular_skeleto	0.69185733
86	MP0002557_abnormal_social/conspecific_i	0.68137123
87	MP0003567_abnormal_fetal_cardiomyocyte	0.67933987
88	MP0003878_abnormal_ear_physiology	0.66713045
89	MP0005377_hearing/vestibular/ear_phenot	0.66713045
90	MP0002638_abnormal_pupillary_reflex	0.66214537
91	MP0000613_abnormal_salivary_gland	0.65339428
92	MP0003635_abnormal_synaptic_transmissio	0.65035090
93	MP0001501_abnormal_sleep_pattern	0.64923197
94	MP0005671_abnormal_response_to	0.62599263
95	MP0003880_abnormal_central_pattern	0.61836481
96	MP0005253_abnormal_eye_physiology	0.60215600
97	MP0009053_abnormal_anal_canal	0.59691567
98	MP0003942_abnormal_urinary_system	0.59638175
99	MP0002067_abnormal_sensory_capabilities	0.59391728
100	MP0005448_abnormal_energy_balance	0.58752696

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.86926181
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.37317188
3	Acute encephalopathy (HP:0006846)	5.09255244
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.90780113
5	Progressive macrocephaly (HP:0004481)	4.87520612
6	Mitochondrial inheritance (HP:0001427)	4.72909258
7	Pendular nystagmus (HP:0012043)	4.65036168
8	Increased CSF lactate (HP:0002490)	4.38654074
9	Reticulocytopenia (HP:0001896)	3.83002200
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.82453226
11	3-Methylglutaconic aciduria (HP:0003535)	3.67533241
12	Increased hepatocellular lipid droplets (HP:0006565)	3.60982934
13	Cerebral edema (HP:0002181)	3.56893798
14	Hepatocellular necrosis (HP:0001404)	3.49534753
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.45698688
16	Abnormal number of erythroid precursors (HP:0012131)	3.32184129
17	Hepatic necrosis (HP:0002605)	3.26700267
18	Optic disc pallor (HP:0000543)	3.16857441
19	Pallor (HP:0000980)	3.15033565
20	Lipid accumulation in hepatocytes (HP:0006561)	3.09843397
21	Decreased central vision (HP:0007663)	3.09363906
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.08357762
23	Renal Fanconi syndrome (HP:0001994)	3.06063772
24	Macrocytic anemia (HP:0001972)	3.02709789
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.02385424
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.02385424
27	Keratoconus (HP:0000563)	3.02289626
28	Increased corneal curvature (HP:0100692)	3.02289626
29	Increased intramyocellular lipid droplets (HP:0012240)	2.90837928
30	Hyperglycinemia (HP:0002154)	2.72790814
31	Increased serum lactate (HP:0002151)	2.72576864
32	Respiratory failure (HP:0002878)	2.70825886
33	Pancreatic cysts (HP:0001737)	2.70545650
34	Absent thumb (HP:0009777)	2.69161561
35	Pancreatic fibrosis (HP:0100732)	2.59140543
36	Lactic acidosis (HP:0003128)	2.57273611
37	Abnormality of midbrain morphology (HP:0002418)	2.54219838
38	Molar tooth sign on MRI (HP:0002419)	2.54219838
39	Abnormality of the renal cortex (HP:0011035)	2.52755589
40	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.52537359
41	Exercise intolerance (HP:0003546)	2.42981330
42	Cerebral hypomyelination (HP:0006808)	2.40590667
43	Cleft eyelid (HP:0000625)	2.40557458
44	Exertional dyspnea (HP:0002875)	2.39248665
45	Leukodystrophy (HP:0002415)	2.39079581
46	Congenital stationary night blindness (HP:0007642)	2.38973360
47	Lethargy (HP:0001254)	2.35664741
48	Attenuation of retinal blood vessels (HP:0007843)	2.35222289
49	Testicular atrophy (HP:0000029)	2.27497691
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26019483
51	Absent/shortened dynein arms (HP:0200106)	2.26019483
52	Increased muscle lipid content (HP:0009058)	2.26016145
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21665640
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.21665640
55	Severe visual impairment (HP:0001141)	2.19608121
56	Chronic hepatic failure (HP:0100626)	2.16504791
57	Self-mutilation (HP:0000742)	2.15177887
58	Progressive microcephaly (HP:0000253)	2.14396491
59	Microretrognathia (HP:0000308)	2.09198490
60	Glycosuria (HP:0003076)	2.06015040
61	Abnormality of urine glucose concentration (HP:0011016)	2.06015040
62	Polydipsia (HP:0001959)	2.04986609
63	Abnormal drinking behavior (HP:0030082)	2.04986609
64	X-linked dominant inheritance (HP:0001423)	2.04581033
65	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01353775
66	Respiratory difficulties (HP:0002880)	2.00326423
67	True hermaphroditism (HP:0010459)	1.99992721
68	Renal cortical cysts (HP:0000803)	1.99165211
69	Asplenia (HP:0001746)	1.97402378
70	Hypoplasia of the radius (HP:0002984)	1.95034550
71	Emotional lability (HP:0000712)	1.94923973
72	Hyperphosphaturia (HP:0003109)	1.94648243
73	CNS demyelination (HP:0007305)	1.91461830
74	Tubular atrophy (HP:0000092)	1.90155236
75	Type II lissencephaly (HP:0007260)	1.87535107
76	Abnormality of renal resorption (HP:0011038)	1.85578077
77	Carpal bone hypoplasia (HP:0001498)	1.82538554
78	Acanthocytosis (HP:0001927)	1.81198900
79	Agitation (HP:0000713)	1.81080867
80	Optic nerve coloboma (HP:0000588)	1.80739300
81	Blindness (HP:0000618)	1.80176879
82	Myokymia (HP:0002411)	1.79087611
83	Nephronophthisis (HP:0000090)	1.78057530
84	CNS hypomyelination (HP:0003429)	1.75697690
85	Irregular epiphyses (HP:0010582)	1.74033736
86	Anencephaly (HP:0002323)	1.72822156
87	Dyskinesia (HP:0100660)	1.72332774
88	Abnormality of the diencephalon (HP:0010662)	1.70720276
89	Pachygyria (HP:0001302)	1.69974562
90	Paralysis (HP:0003470)	1.68898039
91	Sclerocornea (HP:0000647)	1.68569120
92	Hyperthyroidism (HP:0000836)	1.68072239
93	Methylmalonic aciduria (HP:0012120)	1.67285811
94	Abnormal ciliary motility (HP:0012262)	1.66290704
95	Limb dystonia (HP:0002451)	1.64605912
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.63422682
97	Stenosis of the external auditory canal (HP:0000402)	1.62452766
98	Polyuria (HP:0000103)	1.62348331
99	Dysphonia (HP:0001618)	1.61331679
100	Renovascular hypertension (HP:0100817)	1.60722992

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.66171205
2	TIE1	3.46425212
3	WNK3	3.10503793
4	LIMK1	2.81559420
5	ADRBK2	2.64164400
6	GRK1	2.53053073
7	MAP4K1	2.45940941
8	WNK4	2.15560368
9	DYRK2	2.13440906
10	CDK8	2.12058660
11	BMPR1B	2.01693074
12	CAMKK2	1.94604364
13	ZAK	1.88423970
14	FRK	1.84488969
15	BUB1	1.83638713
16	TLK1	1.77653457
17	MAP3K11	1.74910531
18	CDC7	1.73034432
19	BCKDK	1.71703519
20	TNIK	1.68034500
21	RIPK4	1.59136999
22	LRRK2	1.58159094
23	PIK3CA	1.56458371
24	VRK2	1.53843683
25	SIK2	1.37228817
26	NME1	1.32151910
27	NUAK1	1.27682693
28	TXK	1.25489050
29	CDC42BPA	1.23969773
30	SRPK1	1.23252203
31	PRKCG	1.22371395
32	PLK4	1.16477815
33	NEK1	1.15449242
34	PDK2	1.15408936
35	BRSK1	1.11743990
36	STK16	1.09168173
37	AURKA	1.08808544
38	ABL2	1.06385833
39	CASK	0.97771029
40	BMPR2	0.96379587
41	NEK2	0.94602193
42	CAMKK1	0.90780086
43	TGFBR1	0.87800196
44	RPS6KA5	0.86416918
45	CSNK2A2	0.85830297
46	CAMK1D	0.85433749
47	MAPKAPK3	0.85406051
48	NTRK2	0.84687732
49	ADRBK1	0.82231592
50	CAMK1	0.82190992
51	INSRR	0.77707511
52	DYRK3	0.77610310
53	PRKCI	0.75003415
54	VRK1	0.73475097
55	CSNK1G2	0.71852284
56	ACVR1B	0.68650399
57	ATR	0.65550909
58	CSNK1G3	0.64827057
59	AURKB	0.64716951
60	OXSR1	0.63044104
61	MAP3K4	0.62759413
62	PRKACA	0.61707830
63	PLK1	0.61240687
64	KDR	0.60622080
65	CSNK2A1	0.60401746
66	PRKCH	0.58230513
67	FES	0.57988218
68	STK4	0.56215844
69	STK11	0.53150972
70	EIF2AK1	0.51378292
71	MAPK13	0.50460556
72	MAPKAPK5	0.48986255
73	PINK1	0.48704839
74	KIT	0.48431023
75	MKNK2	0.48163464
76	OBSCN	0.47303897
77	PAK3	0.46373829
78	PTK6	0.46006829
79	CHEK1	0.45926670
80	PLK3	0.42611176
81	CSNK1E	0.41178404
82	PAK1	0.39568048
83	CSNK1G1	0.39305458
84	PRKCA	0.39057220
85	MATK	0.38007988
86	CSNK1A1	0.37134832
87	GRK6	0.35550055
88	IKBKB	0.34317611
89	PHKG2	0.34142226
90	PHKG1	0.34142226
91	PRKACG	0.34071276
92	TEC	0.32771377
93	TESK2	0.32569832
94	PRKCZ	0.32318447
95	TYRO3	0.31509182
96	LYN	0.31317175
97	SYK	0.31186568
98	MINK1	0.31126957
99	CAMK4	0.30949558
100	TAF1	0.30871832

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.19742697
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.85775340
3	Parkinsons disease_Homo sapiens_hsa05012	4.01827234
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.14663868
5	Huntingtons disease_Homo sapiens_hsa05016	2.92781432
6	Alzheimers disease_Homo sapiens_hsa05010	2.85999449
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.64492561
8	Sulfur relay system_Homo sapiens_hsa04122	2.55476273
9	RNA polymerase_Homo sapiens_hsa03020	2.36191983
10	Proteasome_Homo sapiens_hsa03050	2.30385872
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.28966922
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18612663
13	Protein export_Homo sapiens_hsa03060	1.97371961
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.89181160
15	Homologous recombination_Homo sapiens_hsa03440	1.81745188
16	DNA replication_Homo sapiens_hsa03030	1.77255591
17	RNA degradation_Homo sapiens_hsa03018	1.72827098
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.71128002
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47717112
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45542540
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36790518
22	Asthma_Homo sapiens_hsa05310	1.34729991
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34582980
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.29181921
25	Base excision repair_Homo sapiens_hsa03410	1.27499341
26	Mismatch repair_Homo sapiens_hsa03430	1.22409345
27	Sulfur metabolism_Homo sapiens_hsa00920	1.22346026
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.19409505
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10743576
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06470338
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00566147
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98712790
33	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.98569825
34	Basal transcription factors_Homo sapiens_hsa03022	0.97828782
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.93484605
36	Purine metabolism_Homo sapiens_hsa00230	0.92988545
37	Spliceosome_Homo sapiens_hsa03040	0.90271208
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.89776771
39	One carbon pool by folate_Homo sapiens_hsa00670	0.88795358
40	Metabolic pathways_Homo sapiens_hsa01100	0.87224891
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85901488
42	Allograft rejection_Homo sapiens_hsa05330	0.85669597
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.84451253
44	Folate biosynthesis_Homo sapiens_hsa00790	0.83634469
45	Selenocompound metabolism_Homo sapiens_hsa00450	0.83142391
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82834639
47	Caffeine metabolism_Homo sapiens_hsa00232	0.81863306
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.78974462
49	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.78640755
50	Peroxisome_Homo sapiens_hsa04146	0.75476567
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.75318440
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74956117
53	RNA transport_Homo sapiens_hsa03013	0.69514672
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.65190556
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64728030
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.64207582
57	Phototransduction_Homo sapiens_hsa04744	0.61559086
58	Tyrosine metabolism_Homo sapiens_hsa00350	0.59221092
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.58990324
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58684373
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.57489188
62	Nicotine addiction_Homo sapiens_hsa05033	0.55747424
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.54990344
64	Retinol metabolism_Homo sapiens_hsa00830	0.54681929
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52858416
66	Olfactory transduction_Homo sapiens_hsa04740	0.52711451
67	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52405424
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.47432100
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45138293
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43249374
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42751710
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42533904
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41892150
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41307071
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40123475
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38655475
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37617547
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36781786
79	Regulation of autophagy_Homo sapiens_hsa04140	0.36185796
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34796147
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31211222
82	Fatty acid degradation_Homo sapiens_hsa00071	0.31071966
83	Glutathione metabolism_Homo sapiens_hsa00480	0.30486415
84	Butanoate metabolism_Homo sapiens_hsa00650	0.29133873
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.28736494
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27031943
87	Morphine addiction_Homo sapiens_hsa05032	0.26552079
88	Rheumatoid arthritis_Homo sapiens_hsa05323	0.26110559
89	Propanoate metabolism_Homo sapiens_hsa00640	0.25139712
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.24176055
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23230014
92	Mineral absorption_Homo sapiens_hsa04978	0.22531562
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.21710073
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.19797292
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19078609
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.17742946
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.17621095
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.17231434
99	Galactose metabolism_Homo sapiens_hsa00052	0.16866347
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.16041452

RPL15P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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