Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 7.41914294 |
2 | ribosomal small subunit assembly (GO:0000028) | 5.40616153 |
3 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.29119553 |
4 | ATP synthesis coupled proton transport (GO:0015986) | 5.23563374 |
5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.23563374 |
6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.14353310 |
7 | cytidine deamination (GO:0009972) | 4.83925540 |
8 | cytidine metabolic process (GO:0046087) | 4.83925540 |
9 | cytidine catabolic process (GO:0006216) | 4.83925540 |
10 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.82579767 |
11 | viral transcription (GO:0019083) | 4.67561243 |
12 | translational termination (GO:0006415) | 4.51612011 |
13 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.31604093 |
14 | cotranslational protein targeting to membrane (GO:0006613) | 4.21895161 |
15 | protein targeting to ER (GO:0045047) | 4.19587367 |
16 | respiratory electron transport chain (GO:0022904) | 4.10048030 |
17 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.09932303 |
18 | translational elongation (GO:0006414) | 4.09924033 |
19 | protein localization to endoplasmic reticulum (GO:0070972) | 4.04835344 |
20 | electron transport chain (GO:0022900) | 4.04183591 |
21 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.98606272 |
22 | ribosomal large subunit biogenesis (GO:0042273) | 3.88191414 |
23 | protein complex biogenesis (GO:0070271) | 3.77464458 |
24 | maturation of SSU-rRNA (GO:0030490) | 3.57627838 |
25 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.49233090 |
26 | NADH dehydrogenase complex assembly (GO:0010257) | 3.49233090 |
27 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.49233090 |
28 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.48999413 |
29 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.48999413 |
30 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.47826589 |
31 | cellular protein complex disassembly (GO:0043624) | 3.46720968 |
32 | ribosomal small subunit biogenesis (GO:0042274) | 3.42829969 |
33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.38329887 |
34 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.35654344 |
35 | negative regulation of mast cell activation (GO:0033004) | 3.31179117 |
36 | viral life cycle (GO:0019058) | 3.28632571 |
37 | base-excision repair, AP site formation (GO:0006285) | 3.18476698 |
38 | translational initiation (GO:0006413) | 3.13625763 |
39 | translation (GO:0006412) | 3.12548266 |
40 | protein neddylation (GO:0045116) | 3.09938740 |
41 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.06521483 |
42 | ATP biosynthetic process (GO:0006754) | 3.05702346 |
43 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.05436177 |
44 | platelet dense granule organization (GO:0060155) | 3.00642388 |
45 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.99696205 |
46 | hydrogen ion transmembrane transport (GO:1902600) | 2.96226364 |
47 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.94571477 |
48 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.93375824 |
49 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.88208132 |
50 | maturation of 5.8S rRNA (GO:0000460) | 2.87796244 |
51 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.84900646 |
52 | termination of RNA polymerase III transcription (GO:0006386) | 2.84900646 |
53 | behavioral response to nicotine (GO:0035095) | 2.84514960 |
54 | proton transport (GO:0015992) | 2.83324724 |
55 | cytochrome complex assembly (GO:0017004) | 2.80436800 |
56 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.77932350 |
57 | hydrogen transport (GO:0006818) | 2.76764725 |
58 | protein complex disassembly (GO:0043241) | 2.76635596 |
59 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 2.69975243 |
60 | macromolecular complex disassembly (GO:0032984) | 2.69902025 |
61 | aldehyde catabolic process (GO:0046185) | 2.69822316 |
62 | deoxyribonucleotide catabolic process (GO:0009264) | 2.67791042 |
63 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.67394514 |
64 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.67032262 |
65 | protein targeting to membrane (GO:0006612) | 2.66989515 |
66 | actin nucleation (GO:0045010) | 2.65063051 |
67 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.64328392 |
68 | protein-cofactor linkage (GO:0018065) | 2.62585260 |
69 | regulation of activation of Janus kinase activity (GO:0010533) | 2.60105441 |
70 | deoxyribose phosphate catabolic process (GO:0046386) | 2.60104681 |
71 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.59915845 |
72 | negative regulation of telomere maintenance (GO:0032205) | 2.59448101 |
73 | GTP biosynthetic process (GO:0006183) | 2.59323725 |
74 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.56741642 |
75 | respiratory chain complex IV assembly (GO:0008535) | 2.55970783 |
76 | positive regulation of interleukin-17 production (GO:0032740) | 2.55465268 |
77 | positive regulation of defense response to virus by host (GO:0002230) | 2.55327327 |
78 | mannosylation (GO:0097502) | 2.55201402 |
79 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.53979339 |
80 | spliceosomal complex assembly (GO:0000245) | 2.52740673 |
81 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.51549790 |
82 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.50998416 |
83 | proteasome assembly (GO:0043248) | 2.50481925 |
84 | positive regulation of calcium-mediated signaling (GO:0050850) | 2.49855257 |
85 | indole-containing compound catabolic process (GO:0042436) | 2.49699527 |
86 | indolalkylamine catabolic process (GO:0046218) | 2.49699527 |
87 | tryptophan catabolic process (GO:0006569) | 2.49699527 |
88 | iron-sulfur cluster assembly (GO:0016226) | 2.49628285 |
89 | metallo-sulfur cluster assembly (GO:0031163) | 2.49628285 |
90 | indolalkylamine metabolic process (GO:0006586) | 2.48941128 |
91 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.48375606 |
92 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.47071957 |
93 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.47071957 |
94 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.47071957 |
95 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.46572208 |
96 | lymphocyte costimulation (GO:0031294) | 2.45859963 |
97 | T cell costimulation (GO:0031295) | 2.45840185 |
98 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.45428803 |
99 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.45064922 |
100 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.44912401 |
Rank | Gene Set | Z-score |
---|---|---|
1 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.26632699 |
2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.01522032 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.42131582 |
4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.34076076 |
5 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.03778311 |
6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.93258545 |
7 | VDR_22108803_ChIP-Seq_LS180_Human | 2.90612379 |
8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.89768996 |
9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.75598497 |
10 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.59066563 |
11 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.58890888 |
12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.54452222 |
13 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.52577652 |
14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.17962615 |
15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.10397168 |
16 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.07512935 |
17 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.05016355 |
18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.00623386 |
19 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.00288257 |
20 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.99537405 |
21 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.98008838 |
22 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.82149122 |
23 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.73490920 |
24 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.66878389 |
25 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.65190533 |
26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.63427540 |
27 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.62560867 |
28 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.59815887 |
29 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.56921362 |
30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.55455889 |
31 | EWS_26573619_Chip-Seq_HEK293_Human | 1.49899823 |
32 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.46284657 |
33 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.45363415 |
34 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.44129752 |
35 | AR_20517297_ChIP-Seq_VCAP_Human | 1.43687531 |
36 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.43361209 |
37 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.43343781 |
38 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.43120897 |
39 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.43120897 |
40 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.41657285 |
41 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.39040426 |
42 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.36590940 |
43 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.36470312 |
44 | GATA3_26560356_Chip-Seq_TH2_Human | 1.36019675 |
45 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35308694 |
46 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.30913153 |
47 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.30407657 |
48 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.28541849 |
49 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.27285356 |
50 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.27258838 |
51 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.27118167 |
52 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.26355246 |
53 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.25505213 |
54 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.25455812 |
55 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.24757036 |
56 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.24757036 |
57 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.23720656 |
58 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.22226963 |
59 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.21114873 |
60 | MYB_26560356_Chip-Seq_TH2_Human | 1.21038126 |
61 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.20835086 |
62 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.18431644 |
63 | FUS_26573619_Chip-Seq_HEK293_Human | 1.17333123 |
64 | P300_19829295_ChIP-Seq_ESCs_Human | 1.16285297 |
65 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.15704429 |
66 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.13352395 |
67 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.13142282 |
68 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.13064527 |
69 | NCOR_22424771_ChIP-Seq_293T_Human | 1.11996659 |
70 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.09077097 |
71 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.08501575 |
72 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.07709712 |
73 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.07283556 |
74 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.05898759 |
75 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.05885699 |
76 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.05602832 |
77 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.04867264 |
78 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.04706221 |
79 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.03791683 |
80 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.03487485 |
81 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.03091433 |
82 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.01848416 |
83 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.01194397 |
84 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.01194397 |
85 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.99046827 |
86 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.98866986 |
87 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.96059639 |
88 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.94911136 |
89 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.94870574 |
90 | ERA_21632823_ChIP-Seq_H3396_Human | 0.94576830 |
91 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.93128712 |
92 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.93074446 |
93 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.92647411 |
94 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.92501358 |
95 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.91086239 |
96 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.90452781 |
97 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.90139431 |
98 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.89917161 |
99 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.89750525 |
100 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.89734753 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005671_abnormal_response_to | 4.28454188 |
2 | MP0009379_abnormal_foot_pigmentation | 3.66723091 |
3 | MP0001835_abnormal_antigen_presentation | 3.41017682 |
4 | MP0001873_stomach_inflammation | 2.79411544 |
5 | MP0006082_CNS_inflammation | 2.74928211 |
6 | MP0003646_muscle_fatigue | 2.70491736 |
7 | MP0005645_abnormal_hypothalamus_physiol | 2.39039588 |
8 | MP0003806_abnormal_nucleotide_metabolis | 2.18331678 |
9 | MP0006292_abnormal_olfactory_placode | 2.15294878 |
10 | MP0009785_altered_susceptibility_to | 2.15223276 |
11 | MP0008875_abnormal_xenobiotic_pharmacok | 2.15165565 |
12 | MP0002837_dystrophic_cardiac_calcinosis | 2.13880878 |
13 | MP0006072_abnormal_retinal_apoptosis | 2.06950914 |
14 | MP0008872_abnormal_physiological_respon | 2.04724228 |
15 | MP0002138_abnormal_hepatobiliary_system | 1.89219646 |
16 | MP0001800_abnormal_humoral_immune | 1.84517198 |
17 | MP0002102_abnormal_ear_morphology | 1.78870535 |
18 | MP0004145_abnormal_muscle_electrophysio | 1.78483616 |
19 | MP0008877_abnormal_DNA_methylation | 1.70901080 |
20 | MP0000685_abnormal_immune_system | 1.65617136 |
21 | MP0002876_abnormal_thyroid_physiology | 1.65552806 |
22 | MP0000372_irregular_coat_pigmentation | 1.61997052 |
23 | MP0002163_abnormal_gland_morphology | 1.61687953 |
24 | MP0001986_abnormal_taste_sensitivity | 1.60897699 |
25 | MP0001968_abnormal_touch/_nociception | 1.59933221 |
26 | MP0005360_urolithiasis | 1.58201677 |
27 | MP0005000_abnormal_immune_tolerance | 1.53805397 |
28 | MP0005387_immune_system_phenotype | 1.52110080 |
29 | MP0001790_abnormal_immune_system | 1.52110080 |
30 | MP0004142_abnormal_muscle_tone | 1.50910698 |
31 | MP0003763_abnormal_thymus_physiology | 1.48262021 |
32 | MP0005551_abnormal_eye_electrophysiolog | 1.48134133 |
33 | MP0003195_calcinosis | 1.47629207 |
34 | MP0001529_abnormal_vocalization | 1.47170985 |
35 | MP0001905_abnormal_dopamine_level | 1.45677027 |
36 | MP0005646_abnormal_pituitary_gland | 1.42036334 |
37 | MP0005025_abnormal_response_to | 1.41572101 |
38 | MP0002723_abnormal_immune_serum | 1.40375141 |
39 | MP0009333_abnormal_splenocyte_physiolog | 1.38462654 |
40 | MP0001919_abnormal_reproductive_system | 1.38278929 |
41 | MP0005389_reproductive_system_phenotype | 1.37972845 |
42 | MP0005084_abnormal_gallbladder_morpholo | 1.37864852 |
43 | MP0002452_abnormal_antigen_presenting | 1.37805717 |
44 | MP0002420_abnormal_adaptive_immunity | 1.35688682 |
45 | MP0002148_abnormal_hypersensitivity_rea | 1.35152184 |
46 | MP0002234_abnormal_pharynx_morphology | 1.34767479 |
47 | MP0001819_abnormal_immune_cell | 1.34440918 |
48 | MP0002277_abnormal_respiratory_mucosa | 1.30812371 |
49 | MP0004147_increased_porphyrin_level | 1.30354064 |
50 | MP0002166_altered_tumor_susceptibility | 1.25467558 |
51 | MP0005075_abnormal_melanosome_morpholog | 1.24151651 |
52 | MP0003878_abnormal_ear_physiology | 1.20204049 |
53 | MP0005377_hearing/vestibular/ear_phenot | 1.20204049 |
54 | MP0001485_abnormal_pinna_reflex | 1.15763764 |
55 | MP0002736_abnormal_nociception_after | 1.13964576 |
56 | MP0008789_abnormal_olfactory_epithelium | 1.12808475 |
57 | MP0005379_endocrine/exocrine_gland_phen | 1.12456529 |
58 | MP0005253_abnormal_eye_physiology | 1.08574305 |
59 | MP0008058_abnormal_DNA_repair | 1.08415265 |
60 | MP0000716_abnormal_immune_system | 1.04094154 |
61 | MP0002095_abnormal_skin_pigmentation | 1.03830423 |
62 | MP0009764_decreased_sensitivity_to | 1.02534996 |
63 | MP0006036_abnormal_mitochondrial_physio | 1.02397787 |
64 | MP0005636_abnormal_mineral_homeostasis | 1.00515440 |
65 | MP0002006_tumorigenesis | 0.99965650 |
66 | MP0001845_abnormal_inflammatory_respons | 0.98719792 |
67 | MP0002160_abnormal_reproductive_system | 0.98432653 |
68 | MP0001984_abnormal_olfaction | 0.96453065 |
69 | MP0010155_abnormal_intestine_physiology | 0.95547643 |
70 | MP0003866_abnormal_defecation | 0.95034186 |
71 | MP0001663_abnormal_digestive_system | 0.94830956 |
72 | MP0003011_delayed_dark_adaptation | 0.94725795 |
73 | MP0005174_abnormal_tail_pigmentation | 0.93841311 |
74 | MP0002638_abnormal_pupillary_reflex | 0.93693310 |
75 | MP0003880_abnormal_central_pattern | 0.93513281 |
76 | MP0003186_abnormal_redox_activity | 0.91794679 |
77 | MP0002272_abnormal_nervous_system | 0.91658458 |
78 | MP0000631_abnormal_neuroendocrine_gland | 0.90379351 |
79 | MP0002398_abnormal_bone_marrow | 0.90347628 |
80 | MP0003252_abnormal_bile_duct | 0.89203819 |
81 | MP0002405_respiratory_system_inflammati | 0.87428097 |
82 | MP0001348_abnormal_lacrimal_gland | 0.86944030 |
83 | MP0004885_abnormal_endolymph | 0.86138193 |
84 | MP0008995_early_reproductive_senescence | 0.85817312 |
85 | MP0003183_abnormal_peptide_metabolism | 0.85188515 |
86 | MP0006276_abnormal_autonomic_nervous | 0.84586745 |
87 | MP0002254_reproductive_system_inflammat | 0.84514094 |
88 | MP0005410_abnormal_fertilization | 0.82836657 |
89 | MP0009046_muscle_twitch | 0.82685457 |
90 | MP0001764_abnormal_homeostasis | 0.79854039 |
91 | MP0001440_abnormal_grooming_behavior | 0.79179884 |
92 | MP0000689_abnormal_spleen_morphology | 0.78043424 |
93 | MP0008469_abnormal_protein_level | 0.77744500 |
94 | MP0003567_abnormal_fetal_cardiomyocyte | 0.77603468 |
95 | MP0002419_abnormal_innate_immunity | 0.77337766 |
96 | MP0002693_abnormal_pancreas_physiology | 0.77220010 |
97 | MP0009745_abnormal_behavioral_response | 0.76102628 |
98 | MP0001970_abnormal_pain_threshold | 0.75829800 |
99 | MP0003786_premature_aging | 0.75656816 |
100 | MP0002429_abnormal_blood_cell | 0.75503747 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 4.48294439 |
2 | Aplastic anemia (HP:0001915) | 4.16112715 |
3 | Mitochondrial inheritance (HP:0001427) | 4.15242012 |
4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.04015824 |
5 | Hepatocellular necrosis (HP:0001404) | 3.99289866 |
6 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.78377275 |
7 | Progressive macrocephaly (HP:0004481) | 3.75768170 |
8 | Congenital stationary night blindness (HP:0007642) | 3.75738210 |
9 | Increased CSF lactate (HP:0002490) | 3.73121435 |
10 | Acute encephalopathy (HP:0006846) | 3.69909675 |
11 | 3-Methylglutaconic aciduria (HP:0003535) | 3.54221851 |
12 | Hepatic necrosis (HP:0002605) | 3.53085619 |
13 | Increased IgM level (HP:0003496) | 3.48968424 |
14 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.39704152 |
15 | Autoimmune hemolytic anemia (HP:0001890) | 3.28760358 |
16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.13702769 |
17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.13702769 |
18 | Autoimmune thrombocytopenia (HP:0001973) | 3.12761247 |
19 | Increased hepatocellular lipid droplets (HP:0006565) | 3.01965275 |
20 | IgG deficiency (HP:0004315) | 2.83880865 |
21 | Abnormality of B cell number (HP:0010975) | 2.83779808 |
22 | Lipid accumulation in hepatocytes (HP:0006561) | 2.82271240 |
23 | Cerebral edema (HP:0002181) | 2.82090082 |
24 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.77593747 |
25 | Agammaglobulinemia (HP:0004432) | 2.77342577 |
26 | Abnormality of T cell number (HP:0011839) | 2.77025341 |
27 | Hypoproteinemia (HP:0003075) | 2.71673274 |
28 | Congenital, generalized hypertrichosis (HP:0004540) | 2.71230727 |
29 | Optic disc pallor (HP:0000543) | 2.68784844 |
30 | Constricted visual fields (HP:0001133) | 2.67635787 |
31 | Abolished electroretinogram (ERG) (HP:0000550) | 2.66987564 |
32 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.62547600 |
33 | Pancreatic cysts (HP:0001737) | 2.61194224 |
34 | Attenuation of retinal blood vessels (HP:0007843) | 2.58923764 |
35 | Renal Fanconi syndrome (HP:0001994) | 2.53097317 |
36 | Increased intramyocellular lipid droplets (HP:0012240) | 2.51869253 |
37 | Reticulocytopenia (HP:0001896) | 2.46143651 |
38 | Severe combined immunodeficiency (HP:0004430) | 2.45077309 |
39 | Exertional dyspnea (HP:0002875) | 2.41546730 |
40 | Abnormality of the prostate (HP:0008775) | 2.38980641 |
41 | Eosinophilia (HP:0001880) | 2.38813687 |
42 | Abnormality of T cells (HP:0002843) | 2.37900943 |
43 | Lactic acidosis (HP:0003128) | 2.37035311 |
44 | Increased serum lactate (HP:0002151) | 2.36022276 |
45 | Methylmalonic acidemia (HP:0002912) | 2.35690869 |
46 | Abnormality of eosinophils (HP:0001879) | 2.32280915 |
47 | Respiratory failure (HP:0002878) | 2.31484290 |
48 | Hypothermia (HP:0002045) | 2.30147811 |
49 | Decreased central vision (HP:0007663) | 2.29450370 |
50 | Lethargy (HP:0001254) | 2.26954285 |
51 | Asplenia (HP:0001746) | 2.26378856 |
52 | B lymphocytopenia (HP:0010976) | 2.23262412 |
53 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.21740689 |
54 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.19218470 |
55 | Medial flaring of the eyebrow (HP:0010747) | 2.17629949 |
56 | Abnormality of T cell physiology (HP:0011840) | 2.16390341 |
57 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.11989078 |
58 | Hyperglycinemia (HP:0002154) | 2.11504575 |
59 | Abnormality of midbrain morphology (HP:0002418) | 2.07168392 |
60 | Molar tooth sign on MRI (HP:0002419) | 2.07168392 |
61 | Thyroiditis (HP:0100646) | 2.07127004 |
62 | Macrocytic anemia (HP:0001972) | 2.06481946 |
63 | Increased muscle lipid content (HP:0009058) | 2.06353671 |
64 | Pendular nystagmus (HP:0012043) | 2.06306640 |
65 | Chronic sinusitis (HP:0011109) | 2.04338561 |
66 | Pancytopenia (HP:0001876) | 2.01995669 |
67 | Methylmalonic aciduria (HP:0012120) | 2.01926630 |
68 | Stomatitis (HP:0010280) | 2.01613231 |
69 | Pancreatic fibrosis (HP:0100732) | 2.00610282 |
70 | Recurrent bronchitis (HP:0002837) | 1.98773166 |
71 | Type II lissencephaly (HP:0007260) | 1.98576044 |
72 | Chronic diarrhea (HP:0002028) | 1.97657149 |
73 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.97266442 |
74 | Recurrent cutaneous fungal infections (HP:0011370) | 1.97056897 |
75 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.97056897 |
76 | True hermaphroditism (HP:0010459) | 1.96816752 |
77 | Leukodystrophy (HP:0002415) | 1.94311207 |
78 | Hypoplasia of the uterus (HP:0000013) | 1.92840886 |
79 | Neutropenia (HP:0001875) | 1.92418307 |
80 | Vasculitis (HP:0002633) | 1.92236776 |
81 | T lymphocytopenia (HP:0005403) | 1.87346986 |
82 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.87251441 |
83 | Absent thumb (HP:0009777) | 1.86589152 |
84 | CNS demyelination (HP:0007305) | 1.85483587 |
85 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.82175620 |
86 | Panhypogammaglobulinemia (HP:0003139) | 1.81504236 |
87 | Abnormality of the renal cortex (HP:0011035) | 1.80584881 |
88 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.80468228 |
89 | Abnormality of alanine metabolism (HP:0010916) | 1.80468228 |
90 | Hyperalaninemia (HP:0003348) | 1.80468228 |
91 | Renal cortical cysts (HP:0000803) | 1.78135847 |
92 | Granulocytopenia (HP:0001913) | 1.75780630 |
93 | Increased corneal curvature (HP:0100692) | 1.75099506 |
94 | Keratoconus (HP:0000563) | 1.75099506 |
95 | Glycosuria (HP:0003076) | 1.75064134 |
96 | Abnormality of urine glucose concentration (HP:0011016) | 1.75064134 |
97 | Combined immunodeficiency (HP:0005387) | 1.74788911 |
98 | Exercise intolerance (HP:0003546) | 1.72770538 |
99 | Brushfield spots (HP:0001088) | 1.70489284 |
100 | Pallor (HP:0000980) | 1.69394748 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TLK1 | 4.93743293 |
2 | TXK | 3.63976039 |
3 | ZAK | 2.87654591 |
4 | KDR | 2.84665324 |
5 | GRK1 | 2.45215213 |
6 | TESK2 | 2.33744410 |
7 | MAP3K13 | 2.26539432 |
8 | MAP4K1 | 2.22731129 |
9 | TAOK3 | 2.19627557 |
10 | BCKDK | 2.16134863 |
11 | MAP3K12 | 2.15292474 |
12 | ADRBK2 | 2.15155433 |
13 | VRK2 | 2.00319524 |
14 | MAP4K2 | 1.96616089 |
15 | PASK | 1.93364282 |
16 | PIK3CA | 1.79479050 |
17 | FRK | 1.78146241 |
18 | KIT | 1.75925832 |
19 | VRK1 | 1.72828396 |
20 | CDK19 | 1.70901834 |
21 | BMPR2 | 1.59710214 |
22 | LIMK1 | 1.57437329 |
23 | SCYL2 | 1.51993981 |
24 | NUAK1 | 1.47626793 |
25 | FES | 1.46986692 |
26 | ITK | 1.40471094 |
27 | INSRR | 1.32781620 |
28 | SYK | 1.28767359 |
29 | OXSR1 | 1.24970752 |
30 | TEC | 1.24276815 |
31 | WNK4 | 1.23880126 |
32 | STK16 | 1.23521804 |
33 | IKBKB | 1.22078276 |
34 | MST4 | 1.20496104 |
35 | MUSK | 1.19325688 |
36 | TIE1 | 1.14444402 |
37 | WNK3 | 1.12359533 |
38 | MYLK | 1.02396338 |
39 | PINK1 | 0.99710534 |
40 | TESK1 | 0.97795896 |
41 | PRKCQ | 0.95137114 |
42 | CAMKK2 | 0.94259579 |
43 | DYRK2 | 0.90497651 |
44 | GRK6 | 0.88075208 |
45 | LYN | 0.87765155 |
46 | RPS6KA5 | 0.87664676 |
47 | BTK | 0.87127073 |
48 | GRK7 | 0.86854430 |
49 | CSF1R | 0.80678771 |
50 | CSNK1G3 | 0.79392919 |
51 | LCK | 0.76049553 |
52 | MAP3K14 | 0.74895123 |
53 | BMPR1B | 0.74528229 |
54 | DAPK3 | 0.74495827 |
55 | PIK3CG | 0.74018706 |
56 | CAMKK1 | 0.70448476 |
57 | PLK4 | 0.66862325 |
58 | TRIM28 | 0.66752236 |
59 | CSNK1G2 | 0.65238651 |
60 | STK39 | 0.64708934 |
61 | OBSCN | 0.64179246 |
62 | DAPK1 | 0.61677073 |
63 | CSNK1G1 | 0.58361912 |
64 | TNK2 | 0.57499425 |
65 | NME2 | 0.55375222 |
66 | IKBKE | 0.55051214 |
67 | FLT3 | 0.55031798 |
68 | MAPK13 | 0.53734440 |
69 | MAP2K6 | 0.53564677 |
70 | ADRBK1 | 0.53486528 |
71 | PKN1 | 0.53021103 |
72 | AURKA | 0.52794351 |
73 | IGF1R | 0.49102795 |
74 | PRKCG | 0.48635122 |
75 | PRKACA | 0.47906320 |
76 | CDK8 | 0.45580265 |
77 | DAPK2 | 0.45010934 |
78 | MAPKAPK5 | 0.44332387 |
79 | JAK3 | 0.43551765 |
80 | CSNK2A2 | 0.43447356 |
81 | PRKCA | 0.43131888 |
82 | EIF2AK3 | 0.42635754 |
83 | SRPK1 | 0.42480459 |
84 | CSNK2A1 | 0.41757106 |
85 | CSNK1A1L | 0.41689433 |
86 | ILK | 0.41064260 |
87 | PRKCE | 0.38011443 |
88 | GRK5 | 0.36577784 |
89 | BUB1 | 0.34762901 |
90 | MAP3K11 | 0.34430545 |
91 | LRRK2 | 0.33816501 |
92 | CASK | 0.33590853 |
93 | CAMK2A | 0.33525470 |
94 | CAMK1 | 0.32820938 |
95 | PIM1 | 0.32537060 |
96 | CSK | 0.32278622 |
97 | CCNB1 | 0.31423839 |
98 | CSNK1A1 | 0.31006795 |
99 | ATR | 0.30845933 |
100 | ABL1 | 0.29216994 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.79067193 |
2 | Ribosome_Homo sapiens_hsa03010 | 3.69947396 |
3 | Allograft rejection_Homo sapiens_hsa05330 | 3.39195100 |
4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.32797482 |
5 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.28120483 |
6 | Asthma_Homo sapiens_hsa05310 | 3.12482468 |
7 | Parkinsons disease_Homo sapiens_hsa05012 | 3.05168598 |
8 | Proteasome_Homo sapiens_hsa03050 | 3.03512600 |
9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.84625437 |
10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.75153717 |
11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.62643179 |
12 | Protein export_Homo sapiens_hsa03060 | 2.32948188 |
13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.10998172 |
14 | Alzheimers disease_Homo sapiens_hsa05010 | 2.01013587 |
15 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.96280279 |
16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.93046978 |
17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.89114790 |
18 | RNA polymerase_Homo sapiens_hsa03020 | 1.86437319 |
19 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.81985136 |
20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.80529163 |
21 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.60822239 |
22 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.57722144 |
23 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.50247572 |
24 | Phototransduction_Homo sapiens_hsa04744 | 1.49469143 |
25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.45474015 |
26 | Homologous recombination_Homo sapiens_hsa03440 | 1.45096430 |
27 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.35791684 |
28 | RNA degradation_Homo sapiens_hsa03018 | 1.27490959 |
29 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.23408887 |
30 | Viral myocarditis_Homo sapiens_hsa05416 | 1.21641820 |
31 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.99126295 |
32 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.97802828 |
33 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.97276501 |
34 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.94416011 |
35 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.94113666 |
36 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.92216424 |
37 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.89290453 |
38 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.87671131 |
39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.85796301 |
40 | Peroxisome_Homo sapiens_hsa04146 | 0.84659040 |
41 | Olfactory transduction_Homo sapiens_hsa04740 | 0.83925556 |
42 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.83669762 |
43 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.83442332 |
44 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.81987305 |
45 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.81226853 |
46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.79051897 |
47 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.76082308 |
48 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.75603710 |
49 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.75308303 |
50 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.74820146 |
51 | Mismatch repair_Homo sapiens_hsa03430 | 0.74689851 |
52 | Retinol metabolism_Homo sapiens_hsa00830 | 0.74361941 |
53 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.73764380 |
54 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.72183363 |
55 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.70844474 |
56 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.70459513 |
57 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.69269697 |
58 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.67033277 |
59 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.65448767 |
60 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.62738570 |
61 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.62276512 |
62 | DNA replication_Homo sapiens_hsa03030 | 0.61716029 |
63 | Leishmaniasis_Homo sapiens_hsa05140 | 0.58437847 |
64 | Purine metabolism_Homo sapiens_hsa00230 | 0.56479166 |
65 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55913890 |
66 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.52386294 |
67 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.51729982 |
68 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.50878481 |
69 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.49342863 |
70 | Nicotine addiction_Homo sapiens_hsa05033 | 0.49001080 |
71 | RNA transport_Homo sapiens_hsa03013 | 0.47987781 |
72 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.47494174 |
73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46129862 |
74 | Basal transcription factors_Homo sapiens_hsa03022 | 0.45969747 |
75 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.45239943 |
76 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.44496510 |
77 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44251359 |
78 | Spliceosome_Homo sapiens_hsa03040 | 0.44190683 |
79 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.43858799 |
80 | Sulfur relay system_Homo sapiens_hsa04122 | 0.43829596 |
81 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.41902678 |
82 | Alcoholism_Homo sapiens_hsa05034 | 0.39855062 |
83 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.39265278 |
84 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.35316850 |
85 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.35162610 |
86 | Malaria_Homo sapiens_hsa05144 | 0.35120168 |
87 | Base excision repair_Homo sapiens_hsa03410 | 0.34798134 |
88 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.34143866 |
89 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.33089786 |
90 | Taste transduction_Homo sapiens_hsa04742 | 0.32858577 |
91 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.31527387 |
92 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.31397436 |
93 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.31186522 |
94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.30694195 |
95 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.24379881 |
96 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.23883611 |
97 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.22907049 |
98 | Measles_Homo sapiens_hsa05162 | 0.22892505 |
99 | Salivary secretion_Homo sapiens_hsa04970 | 0.22594965 |
100 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.22514763 |