RPL15P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.41914294
2ribosomal small subunit assembly (GO:0000028)5.40616153
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.29119553
4ATP synthesis coupled proton transport (GO:0015986)5.23563374
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.23563374
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14353310
7cytidine deamination (GO:0009972)4.83925540
8cytidine metabolic process (GO:0046087)4.83925540
9cytidine catabolic process (GO:0006216)4.83925540
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.82579767
11viral transcription (GO:0019083)4.67561243
12translational termination (GO:0006415)4.51612011
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.31604093
14cotranslational protein targeting to membrane (GO:0006613)4.21895161
15protein targeting to ER (GO:0045047)4.19587367
16respiratory electron transport chain (GO:0022904)4.10048030
17pyrimidine ribonucleoside catabolic process (GO:0046133)4.09932303
18translational elongation (GO:0006414)4.09924033
19protein localization to endoplasmic reticulum (GO:0070972)4.04835344
20electron transport chain (GO:0022900)4.04183591
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.98606272
22ribosomal large subunit biogenesis (GO:0042273)3.88191414
23protein complex biogenesis (GO:0070271)3.77464458
24maturation of SSU-rRNA (GO:0030490)3.57627838
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.49233090
26NADH dehydrogenase complex assembly (GO:0010257)3.49233090
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49233090
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48999413
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48999413
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47826589
31cellular protein complex disassembly (GO:0043624)3.46720968
32ribosomal small subunit biogenesis (GO:0042274)3.42829969
33mitochondrial respiratory chain complex assembly (GO:0033108)3.38329887
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35654344
35negative regulation of mast cell activation (GO:0033004)3.31179117
36viral life cycle (GO:0019058)3.28632571
37base-excision repair, AP site formation (GO:0006285)3.18476698
38translational initiation (GO:0006413)3.13625763
39translation (GO:0006412)3.12548266
40protein neddylation (GO:0045116)3.09938740
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06521483
42ATP biosynthetic process (GO:0006754)3.05702346
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05436177
44platelet dense granule organization (GO:0060155)3.00642388
45water-soluble vitamin biosynthetic process (GO:0042364)2.99696205
46hydrogen ion transmembrane transport (GO:1902600)2.96226364
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94571477
48purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93375824
49Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88208132
50maturation of 5.8S rRNA (GO:0000460)2.87796244
51transcription elongation from RNA polymerase III promoter (GO:0006385)2.84900646
52termination of RNA polymerase III transcription (GO:0006386)2.84900646
53behavioral response to nicotine (GO:0035095)2.84514960
54proton transport (GO:0015992)2.83324724
55cytochrome complex assembly (GO:0017004)2.80436800
56regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.77932350
57hydrogen transport (GO:0006818)2.76764725
58protein complex disassembly (GO:0043241)2.76635596
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.69975243
60macromolecular complex disassembly (GO:0032984)2.69902025
61aldehyde catabolic process (GO:0046185)2.69822316
62deoxyribonucleotide catabolic process (GO:0009264)2.67791042
63regulation of B cell receptor signaling pathway (GO:0050855)2.67394514
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67032262
65protein targeting to membrane (GO:0006612)2.66989515
66actin nucleation (GO:0045010)2.65063051
67purine deoxyribonucleotide catabolic process (GO:0009155)2.64328392
68protein-cofactor linkage (GO:0018065)2.62585260
69regulation of activation of Janus kinase activity (GO:0010533)2.60105441
70deoxyribose phosphate catabolic process (GO:0046386)2.60104681
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.59915845
72negative regulation of telomere maintenance (GO:0032205)2.59448101
73GTP biosynthetic process (GO:0006183)2.59323725
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.56741642
75respiratory chain complex IV assembly (GO:0008535)2.55970783
76positive regulation of interleukin-17 production (GO:0032740)2.55465268
77positive regulation of defense response to virus by host (GO:0002230)2.55327327
78mannosylation (GO:0097502)2.55201402
79positive regulation of T cell mediated cytotoxicity (GO:0001916)2.53979339
80spliceosomal complex assembly (GO:0000245)2.52740673
81nuclear-transcribed mRNA catabolic process (GO:0000956)2.51549790
82regulation of cellular amino acid metabolic process (GO:0006521)2.50998416
83proteasome assembly (GO:0043248)2.50481925
84positive regulation of calcium-mediated signaling (GO:0050850)2.49855257
85indole-containing compound catabolic process (GO:0042436)2.49699527
86indolalkylamine catabolic process (GO:0046218)2.49699527
87tryptophan catabolic process (GO:0006569)2.49699527
88iron-sulfur cluster assembly (GO:0016226)2.49628285
89metallo-sulfur cluster assembly (GO:0031163)2.49628285
90indolalkylamine metabolic process (GO:0006586)2.48941128
91DNA catabolic process, exonucleolytic (GO:0000738)2.48375606
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47071957
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47071957
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47071957
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.46572208
96lymphocyte costimulation (GO:0031294)2.45859963
97T cell costimulation (GO:0031295)2.45840185
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45428803
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.45064922
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.44912401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.26632699
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01522032
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42131582
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.34076076
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.03778311
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93258545
7VDR_22108803_ChIP-Seq_LS180_Human2.90612379
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89768996
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.75598497
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59066563
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.58890888
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54452222
13ZNF274_21170338_ChIP-Seq_K562_Hela2.52577652
14VDR_23849224_ChIP-Seq_CD4+_Human2.17962615
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.10397168
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.07512935
17EZH2_22144423_ChIP-Seq_EOC_Human2.05016355
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00623386
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00288257
20IGF1R_20145208_ChIP-Seq_DFB_Human1.99537405
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98008838
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82149122
23ELK1_19687146_ChIP-ChIP_HELA_Human1.73490920
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.66878389
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65190533
26FOXP3_21729870_ChIP-Seq_TREG_Human1.63427540
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62560867
28TP53_22573176_ChIP-Seq_HFKS_Human1.59815887
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56921362
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55455889
31EWS_26573619_Chip-Seq_HEK293_Human1.49899823
32MYC_18940864_ChIP-ChIP_HL60_Human1.46284657
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45363415
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44129752
35AR_20517297_ChIP-Seq_VCAP_Human1.43687531
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43361209
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43343781
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43120897
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.43120897
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41657285
41IRF1_19129219_ChIP-ChIP_H3396_Human1.39040426
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.36590940
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36470312
44GATA3_26560356_Chip-Seq_TH2_Human1.36019675
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35308694
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30913153
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30407657
48NANOG_20526341_ChIP-Seq_ESCs_Human1.28541849
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.27285356
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.27258838
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27118167
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.26355246
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25505213
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25455812
55NANOG_19829295_ChIP-Seq_ESCs_Human1.24757036
56SOX2_19829295_ChIP-Seq_ESCs_Human1.24757036
57TAF2_19829295_ChIP-Seq_ESCs_Human1.23720656
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22226963
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21114873
60MYB_26560356_Chip-Seq_TH2_Human1.21038126
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20835086
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18431644
63FUS_26573619_Chip-Seq_HEK293_Human1.17333123
64P300_19829295_ChIP-Seq_ESCs_Human1.16285297
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15704429
66ER_23166858_ChIP-Seq_MCF-7_Human1.13352395
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13142282
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13064527
69NCOR_22424771_ChIP-Seq_293T_Human1.11996659
70TAF15_26573619_Chip-Seq_HEK293_Human1.09077097
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08501575
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07709712
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.07283556
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05898759
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05885699
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05602832
77ERG_20517297_ChIP-Seq_VCAP_Human1.04867264
78MYC_19829295_ChIP-Seq_ESCs_Human1.04706221
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03791683
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03487485
81GATA3_27048872_Chip-Seq_THYMUS_Human1.03091433
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.01848416
83CBP_20019798_ChIP-Seq_JUKART_Human1.01194397
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01194397
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99046827
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98866986
87RUNX_20019798_ChIP-Seq_JUKART_Human0.96059639
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94911136
89MYC_18555785_ChIP-Seq_MESCs_Mouse0.94870574
90ERA_21632823_ChIP-Seq_H3396_Human0.94576830
91BCL6_27268052_Chip-Seq_Bcells_Human0.93128712
92BCAT_22108803_ChIP-Seq_LS180_Human0.93074446
93P53_21459846_ChIP-Seq_SAOS-2_Human0.92647411
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.92501358
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91086239
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90452781
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90139431
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.89917161
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89750525
100HOXB7_26014856_ChIP-Seq_BT474_Human0.89734753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.28454188
2MP0009379_abnormal_foot_pigmentation3.66723091
3MP0001835_abnormal_antigen_presentation3.41017682
4MP0001873_stomach_inflammation2.79411544
5MP0006082_CNS_inflammation2.74928211
6MP0003646_muscle_fatigue2.70491736
7MP0005645_abnormal_hypothalamus_physiol2.39039588
8MP0003806_abnormal_nucleotide_metabolis2.18331678
9MP0006292_abnormal_olfactory_placode2.15294878
10MP0009785_altered_susceptibility_to2.15223276
11MP0008875_abnormal_xenobiotic_pharmacok2.15165565
12MP0002837_dystrophic_cardiac_calcinosis2.13880878
13MP0006072_abnormal_retinal_apoptosis2.06950914
14MP0008872_abnormal_physiological_respon2.04724228
15MP0002138_abnormal_hepatobiliary_system1.89219646
16MP0001800_abnormal_humoral_immune1.84517198
17MP0002102_abnormal_ear_morphology1.78870535
18MP0004145_abnormal_muscle_electrophysio1.78483616
19MP0008877_abnormal_DNA_methylation1.70901080
20MP0000685_abnormal_immune_system1.65617136
21MP0002876_abnormal_thyroid_physiology1.65552806
22MP0000372_irregular_coat_pigmentation1.61997052
23MP0002163_abnormal_gland_morphology1.61687953
24MP0001986_abnormal_taste_sensitivity1.60897699
25MP0001968_abnormal_touch/_nociception1.59933221
26MP0005360_urolithiasis1.58201677
27MP0005000_abnormal_immune_tolerance1.53805397
28MP0005387_immune_system_phenotype1.52110080
29MP0001790_abnormal_immune_system1.52110080
30MP0004142_abnormal_muscle_tone1.50910698
31MP0003763_abnormal_thymus_physiology1.48262021
32MP0005551_abnormal_eye_electrophysiolog1.48134133
33MP0003195_calcinosis1.47629207
34MP0001529_abnormal_vocalization1.47170985
35MP0001905_abnormal_dopamine_level1.45677027
36MP0005646_abnormal_pituitary_gland1.42036334
37MP0005025_abnormal_response_to1.41572101
38MP0002723_abnormal_immune_serum1.40375141
39MP0009333_abnormal_splenocyte_physiolog1.38462654
40MP0001919_abnormal_reproductive_system1.38278929
41MP0005389_reproductive_system_phenotype1.37972845
42MP0005084_abnormal_gallbladder_morpholo1.37864852
43MP0002452_abnormal_antigen_presenting1.37805717
44MP0002420_abnormal_adaptive_immunity1.35688682
45MP0002148_abnormal_hypersensitivity_rea1.35152184
46MP0002234_abnormal_pharynx_morphology1.34767479
47MP0001819_abnormal_immune_cell1.34440918
48MP0002277_abnormal_respiratory_mucosa1.30812371
49MP0004147_increased_porphyrin_level1.30354064
50MP0002166_altered_tumor_susceptibility1.25467558
51MP0005075_abnormal_melanosome_morpholog1.24151651
52MP0003878_abnormal_ear_physiology1.20204049
53MP0005377_hearing/vestibular/ear_phenot1.20204049
54MP0001485_abnormal_pinna_reflex1.15763764
55MP0002736_abnormal_nociception_after1.13964576
56MP0008789_abnormal_olfactory_epithelium1.12808475
57MP0005379_endocrine/exocrine_gland_phen1.12456529
58MP0005253_abnormal_eye_physiology1.08574305
59MP0008058_abnormal_DNA_repair1.08415265
60MP0000716_abnormal_immune_system1.04094154
61MP0002095_abnormal_skin_pigmentation1.03830423
62MP0009764_decreased_sensitivity_to1.02534996
63MP0006036_abnormal_mitochondrial_physio1.02397787
64MP0005636_abnormal_mineral_homeostasis1.00515440
65MP0002006_tumorigenesis0.99965650
66MP0001845_abnormal_inflammatory_respons0.98719792
67MP0002160_abnormal_reproductive_system0.98432653
68MP0001984_abnormal_olfaction0.96453065
69MP0010155_abnormal_intestine_physiology0.95547643
70MP0003866_abnormal_defecation0.95034186
71MP0001663_abnormal_digestive_system0.94830956
72MP0003011_delayed_dark_adaptation0.94725795
73MP0005174_abnormal_tail_pigmentation0.93841311
74MP0002638_abnormal_pupillary_reflex0.93693310
75MP0003880_abnormal_central_pattern0.93513281
76MP0003186_abnormal_redox_activity0.91794679
77MP0002272_abnormal_nervous_system0.91658458
78MP0000631_abnormal_neuroendocrine_gland0.90379351
79MP0002398_abnormal_bone_marrow0.90347628
80MP0003252_abnormal_bile_duct0.89203819
81MP0002405_respiratory_system_inflammati0.87428097
82MP0001348_abnormal_lacrimal_gland0.86944030
83MP0004885_abnormal_endolymph0.86138193
84MP0008995_early_reproductive_senescence0.85817312
85MP0003183_abnormal_peptide_metabolism0.85188515
86MP0006276_abnormal_autonomic_nervous0.84586745
87MP0002254_reproductive_system_inflammat0.84514094
88MP0005410_abnormal_fertilization0.82836657
89MP0009046_muscle_twitch0.82685457
90MP0001764_abnormal_homeostasis0.79854039
91MP0001440_abnormal_grooming_behavior0.79179884
92MP0000689_abnormal_spleen_morphology0.78043424
93MP0008469_abnormal_protein_level0.77744500
94MP0003567_abnormal_fetal_cardiomyocyte0.77603468
95MP0002419_abnormal_innate_immunity0.77337766
96MP0002693_abnormal_pancreas_physiology0.77220010
97MP0009745_abnormal_behavioral_response0.76102628
98MP0001970_abnormal_pain_threshold0.75829800
99MP0003786_premature_aging0.75656816
100MP0002429_abnormal_blood_cell0.75503747

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.48294439
2Aplastic anemia (HP:0001915)4.16112715
3Mitochondrial inheritance (HP:0001427)4.15242012
4Abnormal mitochondria in muscle tissue (HP:0008316)4.04015824
5Hepatocellular necrosis (HP:0001404)3.99289866
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.78377275
7Progressive macrocephaly (HP:0004481)3.75768170
8Congenital stationary night blindness (HP:0007642)3.75738210
9Increased CSF lactate (HP:0002490)3.73121435
10Acute encephalopathy (HP:0006846)3.69909675
113-Methylglutaconic aciduria (HP:0003535)3.54221851
12Hepatic necrosis (HP:0002605)3.53085619
13Increased IgM level (HP:0003496)3.48968424
14Abnormal rod and cone electroretinograms (HP:0008323)3.39704152
15Autoimmune hemolytic anemia (HP:0001890)3.28760358
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13702769
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13702769
18Autoimmune thrombocytopenia (HP:0001973)3.12761247
19Increased hepatocellular lipid droplets (HP:0006565)3.01965275
20IgG deficiency (HP:0004315)2.83880865
21Abnormality of B cell number (HP:0010975)2.83779808
22Lipid accumulation in hepatocytes (HP:0006561)2.82271240
23Cerebral edema (HP:0002181)2.82090082
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.77593747
25Agammaglobulinemia (HP:0004432)2.77342577
26Abnormality of T cell number (HP:0011839)2.77025341
27Hypoproteinemia (HP:0003075)2.71673274
28Congenital, generalized hypertrichosis (HP:0004540)2.71230727
29Optic disc pallor (HP:0000543)2.68784844
30Constricted visual fields (HP:0001133)2.67635787
31Abolished electroretinogram (ERG) (HP:0000550)2.66987564
32Elevated erythrocyte sedimentation rate (HP:0003565)2.62547600
33Pancreatic cysts (HP:0001737)2.61194224
34Attenuation of retinal blood vessels (HP:0007843)2.58923764
35Renal Fanconi syndrome (HP:0001994)2.53097317
36Increased intramyocellular lipid droplets (HP:0012240)2.51869253
37Reticulocytopenia (HP:0001896)2.46143651
38Severe combined immunodeficiency (HP:0004430)2.45077309
39Exertional dyspnea (HP:0002875)2.41546730
40Abnormality of the prostate (HP:0008775)2.38980641
41Eosinophilia (HP:0001880)2.38813687
42Abnormality of T cells (HP:0002843)2.37900943
43Lactic acidosis (HP:0003128)2.37035311
44Increased serum lactate (HP:0002151)2.36022276
45Methylmalonic acidemia (HP:0002912)2.35690869
46Abnormality of eosinophils (HP:0001879)2.32280915
47Respiratory failure (HP:0002878)2.31484290
48Hypothermia (HP:0002045)2.30147811
49Decreased central vision (HP:0007663)2.29450370
50Lethargy (HP:0001254)2.26954285
51Asplenia (HP:0001746)2.26378856
52B lymphocytopenia (HP:0010976)2.23262412
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21740689
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.19218470
55Medial flaring of the eyebrow (HP:0010747)2.17629949
56Abnormality of T cell physiology (HP:0011840)2.16390341
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11989078
58Hyperglycinemia (HP:0002154)2.11504575
59Abnormality of midbrain morphology (HP:0002418)2.07168392
60Molar tooth sign on MRI (HP:0002419)2.07168392
61Thyroiditis (HP:0100646)2.07127004
62Macrocytic anemia (HP:0001972)2.06481946
63Increased muscle lipid content (HP:0009058)2.06353671
64Pendular nystagmus (HP:0012043)2.06306640
65Chronic sinusitis (HP:0011109)2.04338561
66Pancytopenia (HP:0001876)2.01995669
67Methylmalonic aciduria (HP:0012120)2.01926630
68Stomatitis (HP:0010280)2.01613231
69Pancreatic fibrosis (HP:0100732)2.00610282
70Recurrent bronchitis (HP:0002837)1.98773166
71Type II lissencephaly (HP:0007260)1.98576044
72Chronic diarrhea (HP:0002028)1.97657149
73Aplasia/hypoplasia of the uterus (HP:0008684)1.97266442
74Recurrent cutaneous fungal infections (HP:0011370)1.97056897
75Chronic mucocutaneous candidiasis (HP:0002728)1.97056897
76True hermaphroditism (HP:0010459)1.96816752
77Leukodystrophy (HP:0002415)1.94311207
78Hypoplasia of the uterus (HP:0000013)1.92840886
79Neutropenia (HP:0001875)1.92418307
80Vasculitis (HP:0002633)1.92236776
81T lymphocytopenia (HP:0005403)1.87346986
82Abnormality of cells of the erythroid lineage (HP:0012130)1.87251441
83Absent thumb (HP:0009777)1.86589152
84CNS demyelination (HP:0007305)1.85483587
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82175620
86Panhypogammaglobulinemia (HP:0003139)1.81504236
87Abnormality of the renal cortex (HP:0011035)1.80584881
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80468228
89Abnormality of alanine metabolism (HP:0010916)1.80468228
90Hyperalaninemia (HP:0003348)1.80468228
91Renal cortical cysts (HP:0000803)1.78135847
92Granulocytopenia (HP:0001913)1.75780630
93Increased corneal curvature (HP:0100692)1.75099506
94Keratoconus (HP:0000563)1.75099506
95Glycosuria (HP:0003076)1.75064134
96Abnormality of urine glucose concentration (HP:0011016)1.75064134
97Combined immunodeficiency (HP:0005387)1.74788911
98Exercise intolerance (HP:0003546)1.72770538
99Brushfield spots (HP:0001088)1.70489284
100Pallor (HP:0000980)1.69394748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.93743293
2TXK3.63976039
3ZAK2.87654591
4KDR2.84665324
5GRK12.45215213
6TESK22.33744410
7MAP3K132.26539432
8MAP4K12.22731129
9TAOK32.19627557
10BCKDK2.16134863
11MAP3K122.15292474
12ADRBK22.15155433
13VRK22.00319524
14MAP4K21.96616089
15PASK1.93364282
16PIK3CA1.79479050
17FRK1.78146241
18KIT1.75925832
19VRK11.72828396
20CDK191.70901834
21BMPR21.59710214
22LIMK11.57437329
23SCYL21.51993981
24NUAK11.47626793
25FES1.46986692
26ITK1.40471094
27INSRR1.32781620
28SYK1.28767359
29OXSR11.24970752
30TEC1.24276815
31WNK41.23880126
32STK161.23521804
33IKBKB1.22078276
34MST41.20496104
35MUSK1.19325688
36TIE11.14444402
37WNK31.12359533
38MYLK1.02396338
39PINK10.99710534
40TESK10.97795896
41PRKCQ0.95137114
42CAMKK20.94259579
43DYRK20.90497651
44GRK60.88075208
45LYN0.87765155
46RPS6KA50.87664676
47BTK0.87127073
48GRK70.86854430
49CSF1R0.80678771
50CSNK1G30.79392919
51LCK0.76049553
52MAP3K140.74895123
53BMPR1B0.74528229
54DAPK30.74495827
55PIK3CG0.74018706
56CAMKK10.70448476
57PLK40.66862325
58TRIM280.66752236
59CSNK1G20.65238651
60STK390.64708934
61OBSCN0.64179246
62DAPK10.61677073
63CSNK1G10.58361912
64TNK20.57499425
65NME20.55375222
66IKBKE0.55051214
67FLT30.55031798
68MAPK130.53734440
69MAP2K60.53564677
70ADRBK10.53486528
71PKN10.53021103
72AURKA0.52794351
73IGF1R0.49102795
74PRKCG0.48635122
75PRKACA0.47906320
76CDK80.45580265
77DAPK20.45010934
78MAPKAPK50.44332387
79JAK30.43551765
80CSNK2A20.43447356
81PRKCA0.43131888
82EIF2AK30.42635754
83SRPK10.42480459
84CSNK2A10.41757106
85CSNK1A1L0.41689433
86ILK0.41064260
87PRKCE0.38011443
88GRK50.36577784
89BUB10.34762901
90MAP3K110.34430545
91LRRK20.33816501
92CASK0.33590853
93CAMK2A0.33525470
94CAMK10.32820938
95PIM10.32537060
96CSK0.32278622
97CCNB10.31423839
98CSNK1A10.31006795
99ATR0.30845933
100ABL10.29216994

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.79067193
2Ribosome_Homo sapiens_hsa030103.69947396
3Allograft rejection_Homo sapiens_hsa053303.39195100
4Autoimmune thyroid disease_Homo sapiens_hsa053203.32797482
5Graft-versus-host disease_Homo sapiens_hsa053323.28120483
6Asthma_Homo sapiens_hsa053103.12482468
7Parkinsons disease_Homo sapiens_hsa050123.05168598
8Proteasome_Homo sapiens_hsa030503.03512600
9Type I diabetes mellitus_Homo sapiens_hsa049402.84625437
10Primary immunodeficiency_Homo sapiens_hsa053402.75153717
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.62643179
12Protein export_Homo sapiens_hsa030602.32948188
13Antigen processing and presentation_Homo sapiens_hsa046122.10998172
14Alzheimers disease_Homo sapiens_hsa050102.01013587
15Caffeine metabolism_Homo sapiens_hsa002321.96280279
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93046978
17Huntingtons disease_Homo sapiens_hsa050161.89114790
18RNA polymerase_Homo sapiens_hsa030201.86437319
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81985136
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80529163
21Cardiac muscle contraction_Homo sapiens_hsa042601.60822239
22Rheumatoid arthritis_Homo sapiens_hsa053231.57722144
23Systemic lupus erythematosus_Homo sapiens_hsa053221.50247572
24Phototransduction_Homo sapiens_hsa047441.49469143
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45474015
26Homologous recombination_Homo sapiens_hsa034401.45096430
27Linoleic acid metabolism_Homo sapiens_hsa005911.35791684
28RNA degradation_Homo sapiens_hsa030181.27490959
29Hematopoietic cell lineage_Homo sapiens_hsa046401.23408887
30Viral myocarditis_Homo sapiens_hsa054161.21641820
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99126295
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97802828
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97276501
34Tryptophan metabolism_Homo sapiens_hsa003800.94416011
35Staphylococcus aureus infection_Homo sapiens_hsa051500.94113666
36Fanconi anemia pathway_Homo sapiens_hsa034600.92216424
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89290453
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.87671131
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85796301
40Peroxisome_Homo sapiens_hsa041460.84659040
41Olfactory transduction_Homo sapiens_hsa047400.83925556
42One carbon pool by folate_Homo sapiens_hsa006700.83669762
43Pyrimidine metabolism_Homo sapiens_hsa002400.83442332
44Collecting duct acid secretion_Homo sapiens_hsa049660.81987305
45Chemical carcinogenesis_Homo sapiens_hsa052040.81226853
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79051897
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76082308
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75603710
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75308303
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74820146
51Mismatch repair_Homo sapiens_hsa034300.74689851
52Retinol metabolism_Homo sapiens_hsa008300.74361941
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.73764380
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72183363
55Nitrogen metabolism_Homo sapiens_hsa009100.70844474
56Arachidonic acid metabolism_Homo sapiens_hsa005900.70459513
57Propanoate metabolism_Homo sapiens_hsa006400.69269697
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67033277
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65448767
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62738570
61African trypanosomiasis_Homo sapiens_hsa051430.62276512
62DNA replication_Homo sapiens_hsa030300.61716029
63Leishmaniasis_Homo sapiens_hsa051400.58437847
64Purine metabolism_Homo sapiens_hsa002300.56479166
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55913890
66Ether lipid metabolism_Homo sapiens_hsa005650.52386294
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.51729982
68T cell receptor signaling pathway_Homo sapiens_hsa046600.50878481
69Butanoate metabolism_Homo sapiens_hsa006500.49342863
70Nicotine addiction_Homo sapiens_hsa050330.49001080
71RNA transport_Homo sapiens_hsa030130.47987781
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47494174
73Metabolic pathways_Homo sapiens_hsa011000.46129862
74Basal transcription factors_Homo sapiens_hsa030220.45969747
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45239943
76Sulfur metabolism_Homo sapiens_hsa009200.44496510
77Regulation of autophagy_Homo sapiens_hsa041400.44251359
78Spliceosome_Homo sapiens_hsa030400.44190683
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.43858799
80Sulfur relay system_Homo sapiens_hsa041220.43829596
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.41902678
82Alcoholism_Homo sapiens_hsa050340.39855062
83Fat digestion and absorption_Homo sapiens_hsa049750.39265278
84Nucleotide excision repair_Homo sapiens_hsa034200.35316850
85Fatty acid elongation_Homo sapiens_hsa000620.35162610
86Malaria_Homo sapiens_hsa051440.35120168
87Base excision repair_Homo sapiens_hsa034100.34798134
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34143866
89Herpes simplex infection_Homo sapiens_hsa051680.33089786
90Taste transduction_Homo sapiens_hsa047420.32858577
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31527387
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.31397436
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31186522
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30694195
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24379881
96Tyrosine metabolism_Homo sapiens_hsa003500.23883611
97beta-Alanine metabolism_Homo sapiens_hsa004100.22907049
98Measles_Homo sapiens_hsa051620.22892505
99Salivary secretion_Homo sapiens_hsa049700.22594965
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22514763

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