RPL15P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)7.06542820
2purinergic nucleotide receptor signaling pathway (GO:0035590)5.62040575
3regulation of skeletal muscle contraction (GO:0014819)5.39515456
4DNA deamination (GO:0045006)5.15846489
5behavioral response to nicotine (GO:0035095)5.07735555
6DNA strand renaturation (GO:0000733)5.07440939
7mitotic cell cycle arrest (GO:0071850)4.88067152
8negative regulation of cell aging (GO:0090344)4.72699656
9detection of light stimulus involved in sensory perception (GO:0050962)4.52936066
10detection of light stimulus involved in visual perception (GO:0050908)4.52936066
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.49595735
12rRNA modification (GO:0000154)4.36790427
13GDP-mannose metabolic process (GO:0019673)4.35890084
14rRNA methylation (GO:0031167)4.17327553
15transepithelial transport (GO:0070633)4.10034709
16regulation of synapse structural plasticity (GO:0051823)4.00534107
17cellular response to exogenous dsRNA (GO:0071360)4.00480151
18metallo-sulfur cluster assembly (GO:0031163)3.97515441
19iron-sulfur cluster assembly (GO:0016226)3.97515441
20water-soluble vitamin biosynthetic process (GO:0042364)3.82879256
21lens fiber cell differentiation (GO:0070306)3.72182595
22response to ATP (GO:0033198)3.71840496
23purinergic receptor signaling pathway (GO:0035587)3.60085033
24positive regulation of calcium-mediated signaling (GO:0050850)3.57165000
25mannosylation (GO:0097502)3.44984246
26transcription elongation from RNA polymerase III promoter (GO:0006385)3.36746730
27termination of RNA polymerase III transcription (GO:0006386)3.36746730
28positive regulation of defense response to virus by host (GO:0002230)3.33554332
29grooming behavior (GO:0007625)3.28639918
30interferon-gamma production (GO:0032609)3.28477919
31piRNA metabolic process (GO:0034587)3.26391022
32estrogen biosynthetic process (GO:0006703)3.25858346
33regulation of T cell receptor signaling pathway (GO:0050856)3.25829029
34regulation of cytokine production involved in inflammatory response (GO:1900015)3.23906668
35protein deneddylation (GO:0000338)3.23690630
36dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.18578009
37meiotic chromosome segregation (GO:0045132)3.17662044
38respiratory chain complex IV assembly (GO:0008535)3.15132751
39purine ribonucleotide transport (GO:0015868)3.13431631
40regulation of mitotic spindle checkpoint (GO:1903504)3.01275782
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01275782
42pseudouridine synthesis (GO:0001522)2.99730440
43ubiquinone biosynthetic process (GO:0006744)2.98770778
44negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.98491539
45proteasome assembly (GO:0043248)2.95891197
46regulation of nuclear cell cycle DNA replication (GO:0033262)2.95535273
47negative regulation of telomere maintenance (GO:0032205)2.94720253
48response to gravity (GO:0009629)2.92790698
49nucleoside transmembrane transport (GO:1901642)2.91076878
50protein carboxylation (GO:0018214)2.90905516
51peptidyl-glutamic acid carboxylation (GO:0017187)2.90905516
52protein complex biogenesis (GO:0070271)2.90515904
53mast cell degranulation (GO:0043303)2.89632547
54mast cell activation involved in immune response (GO:0002279)2.89632547
55endoderm formation (GO:0001706)2.89476917
56sleep (GO:0030431)2.88221397
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86715198
58tRNA modification (GO:0006400)2.86124267
59base-excision repair, AP site formation (GO:0006285)2.86065706
60regulation of defense response to virus by host (GO:0050691)2.84526032
61neuronal action potential (GO:0019228)2.84373639
62positive regulation of protein kinase C signaling (GO:0090037)2.84331530
63cullin deneddylation (GO:0010388)2.83745309
64reciprocal meiotic recombination (GO:0007131)2.82619005
65reciprocal DNA recombination (GO:0035825)2.82619005
66indolalkylamine metabolic process (GO:0006586)2.76289587
67tRNA processing (GO:0008033)2.76011007
68DNA methylation involved in gamete generation (GO:0043046)2.74295094
69positive regulation of protein homodimerization activity (GO:0090073)2.72145752
70preassembly of GPI anchor in ER membrane (GO:0016254)2.71559154
71mitochondrial calcium ion transport (GO:0006851)2.71552221
72adenine nucleotide transport (GO:0051503)2.71518650
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69653792
74cytidine deamination (GO:0009972)2.66363980
75cytidine metabolic process (GO:0046087)2.66363980
76cytidine catabolic process (GO:0006216)2.66363980
77positive regulation of prostaglandin secretion (GO:0032308)2.65949169
78mast cell activation (GO:0045576)2.64404158
79purine deoxyribonucleotide catabolic process (GO:0009155)2.64262546
80phosphorylated carbohydrate dephosphorylation (GO:0046838)2.63295399
81inositol phosphate dephosphorylation (GO:0046855)2.63295399
82cytochrome complex assembly (GO:0017004)2.62973164
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62756069
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62756069
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58563934
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.58563934
87NADH dehydrogenase complex assembly (GO:0010257)2.58563934
88mitochondrial respiratory chain complex assembly (GO:0033108)2.57795363
89RNA destabilization (GO:0050779)2.56338904
90S-adenosylmethionine metabolic process (GO:0046500)2.55740226
91energy coupled proton transport, down electrochemical gradient (GO:0015985)2.55143224
92ATP synthesis coupled proton transport (GO:0015986)2.55143224
93regulation of interleukin-8 secretion (GO:2000482)2.54991983
94nucleoside transport (GO:0015858)2.54185874
95regulation of calcium-mediated signaling (GO:0050848)2.53780908
96cellular response to dsRNA (GO:0071359)2.53024799
97synaptic transmission, cholinergic (GO:0007271)2.52279965
98ubiquinone metabolic process (GO:0006743)2.50959349
99regulation of phospholipid biosynthetic process (GO:0071071)2.49109000
100chaperone-mediated protein transport (GO:0072321)2.48980714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.19418444
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35546233
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.01590229
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96647088
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.67742725
6CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47293750
7BCL6_27268052_Chip-Seq_Bcells_Human2.36440867
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.35161910
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33811614
10XRN2_22483619_ChIP-Seq_HELA_Human2.30532630
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25473436
12E2F1_20622854_ChIP-Seq_HELA_Human2.25188663
13VDR_23849224_ChIP-Seq_CD4+_Human2.20261125
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.15285748
15P68_20966046_ChIP-Seq_HELA_Human2.11614190
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.11406916
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.10732790
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.06338353
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.02013467
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00470385
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.94261624
22MAF_26560356_Chip-Seq_TH2_Human1.93630895
23VDR_22108803_ChIP-Seq_LS180_Human1.92980142
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91276418
25ERA_21632823_ChIP-Seq_H3396_Human1.90627460
26BCOR_27268052_Chip-Seq_Bcells_Human1.88325576
27VDR_21846776_ChIP-Seq_THP-1_Human1.85631855
28TP53_22573176_ChIP-Seq_HFKS_Human1.82631935
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.77860525
30CTCF_20526341_ChIP-Seq_ESCs_Human1.77393323
31FOXP3_21729870_ChIP-Seq_TREG_Human1.73708381
32CIITA_25753668_ChIP-Seq_RAJI_Human1.73265072
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70761520
34ZNF274_21170338_ChIP-Seq_K562_Hela1.70112291
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69061331
36MAF_26560356_Chip-Seq_TH1_Human1.67481521
37NANOG_20526341_ChIP-Seq_ESCs_Human1.67408247
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65540117
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63600403
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61863940
41PHF8_20622854_ChIP-Seq_HELA_Human1.61221460
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60883503
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57670338
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.56644950
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.56268045
46DCP1A_22483619_ChIP-Seq_HELA_Human1.55487077
47TAF2_19829295_ChIP-Seq_ESCs_Human1.55141935
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54817293
49EWS_26573619_Chip-Seq_HEK293_Human1.54360317
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54060581
51RARB_24833708_ChIP-Seq_LIVER_Mouse1.54018932
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.51423471
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51397472
54MYC_19829295_ChIP-Seq_ESCs_Human1.49299482
55CTCF_27219007_Chip-Seq_Bcells_Human1.48125520
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45998472
57OCT4_20526341_ChIP-Seq_ESCs_Human1.44830595
58GABP_19822575_ChIP-Seq_HepG2_Human1.43473419
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43161238
60P300_27268052_Chip-Seq_Bcells_Human1.42885840
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.41873384
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41750593
63P53_21459846_ChIP-Seq_SAOS-2_Human1.41266983
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39362434
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37539553
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.35200682
67GATA3_26560356_Chip-Seq_TH2_Human1.31799393
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31632182
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30057078
70SA1_27219007_Chip-Seq_Bcells_Human1.29479206
71RAC3_21632823_ChIP-Seq_H3396_Human1.28218128
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27646814
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.25586373
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.24583243
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23314878
76MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23210525
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22926690
78RARA_24833708_ChIP-Seq_LIVER_Mouse1.22841130
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22288603
80UTX_26944678_Chip-Seq_JUKART_Human1.20292846
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20219133
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19657596
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19415972
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.17930474
85RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17480447
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16218016
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13464144
88ERG_20517297_ChIP-Seq_VCAP_Human1.13065828
89TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12448386
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.11728705
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10533529
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09884065
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09829770
94CTCF_21964334_Chip-Seq_Bcells_Human1.09073036
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08922575
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06573607
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.06528071
98SOX2_21211035_ChIP-Seq_LN229_Human1.06339361
99AR_20517297_ChIP-Seq_VCAP_Human1.03815985
100ETS1_21867929_ChIP-Seq_TH2_Mouse1.00774231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity5.70456047
2MP0005171_absent_coat_pigmentation4.45876925
3MP0005423_abnormal_somatic_nervous3.98691337
4MP0008875_abnormal_xenobiotic_pharmacok3.75842418
5MP0005174_abnormal_tail_pigmentation3.60408089
6MP0001968_abnormal_touch/_nociception3.21781542
7MP0002736_abnormal_nociception_after2.63873974
8MP0003136_yellow_coat_color2.63298702
9MP0005671_abnormal_response_to2.39159461
10MP0001835_abnormal_antigen_presentation2.18433835
11MP0003806_abnormal_nucleotide_metabolis2.16123994
12MP0002102_abnormal_ear_morphology2.07261992
13MP0001188_hyperpigmentation2.02851702
14MP0003724_increased_susceptibility_to2.02662836
15MP0002138_abnormal_hepatobiliary_system1.95426441
16MP0005551_abnormal_eye_electrophysiolog1.93935833
17MP0005083_abnormal_biliary_tract1.83385158
18MP0001756_abnormal_urination1.79813438
19MP0005084_abnormal_gallbladder_morpholo1.78671889
20MP0005365_abnormal_bile_salt1.76832506
21MP0001661_extended_life_span1.75649143
22MP0002638_abnormal_pupillary_reflex1.71767583
23MP0003878_abnormal_ear_physiology1.69223977
24MP0005377_hearing/vestibular/ear_phenot1.69223977
25MP0006072_abnormal_retinal_apoptosis1.66964162
26MP0005253_abnormal_eye_physiology1.65736562
27MP0005410_abnormal_fertilization1.64289524
28MP0006276_abnormal_autonomic_nervous1.57577759
29MP0002735_abnormal_chemical_nociception1.51974561
30MP0008877_abnormal_DNA_methylation1.51571321
31MP0006036_abnormal_mitochondrial_physio1.44319954
32MP0003718_maternal_effect1.42748507
33MP0001905_abnormal_dopamine_level1.38805648
34MP0002148_abnormal_hypersensitivity_rea1.38294463
35MP0005167_abnormal_blood-brain_barrier1.37936695
36MP0010386_abnormal_urinary_bladder1.36349904
37MP0008775_abnormal_heart_ventricle1.33759883
38MP0002160_abnormal_reproductive_system1.32590734
39MP0001800_abnormal_humoral_immune1.32408623
40MP0000372_irregular_coat_pigmentation1.31154344
41MP0002723_abnormal_immune_serum1.30223436
42MP0000685_abnormal_immune_system1.26390748
43MP0002933_joint_inflammation1.25565648
44MP0006082_CNS_inflammation1.23327782
45MP0000538_abnormal_urinary_bladder1.22824152
46MP0008872_abnormal_physiological_respon1.19609629
47MP0005332_abnormal_amino_acid1.19064254
48MP0001502_abnormal_circadian_rhythm1.15168263
49MP0001919_abnormal_reproductive_system1.14813297
50MP0002452_abnormal_antigen_presenting1.14423871
51MP0004215_abnormal_myocardial_fiber1.12807093
52MP0004043_abnormal_pH_regulation1.11262306
53MP0009785_altered_susceptibility_to1.11145565
54MP0009643_abnormal_urine_homeostasis1.09104384
55MP0001970_abnormal_pain_threshold1.08284060
56MP0002653_abnormal_ependyma_morphology1.07815471
57MP0005000_abnormal_immune_tolerance1.05997240
58MP0002420_abnormal_adaptive_immunity1.05818151
59MP0001873_stomach_inflammation1.05520510
60MP0001819_abnormal_immune_cell1.04562055
61MP0005330_cardiomyopathy1.04022235
62MP0003011_delayed_dark_adaptation1.03259134
63MP0001765_abnormal_ion_homeostasis1.03051953
64MP0002166_altered_tumor_susceptibility1.02142560
65MP0003763_abnormal_thymus_physiology1.00291427
66MP0003786_premature_aging0.95439347
67MP0000013_abnormal_adipose_tissue0.94806960
68MP0004147_increased_porphyrin_level0.94642429
69MP0005389_reproductive_system_phenotype0.91742242
70MP0000015_abnormal_ear_pigmentation0.91712430
71MP0004381_abnormal_hair_follicle0.89247962
72MP0006035_abnormal_mitochondrial_morpho0.88333346
73MP0002006_tumorigenesis0.87042571
74MP0005646_abnormal_pituitary_gland0.85789977
75MP0001790_abnormal_immune_system0.85741516
76MP0005387_immune_system_phenotype0.85741516
77MP0002019_abnormal_tumor_incidence0.84352579
78MP0005025_abnormal_response_to0.83575060
79MP0000689_abnormal_spleen_morphology0.78731902
80MP0003111_abnormal_nucleus_morphology0.78613910
81MP0000230_abnormal_systemic_arterial0.78108595
82MP0002733_abnormal_thermal_nociception0.77176589
83MP0002136_abnormal_kidney_physiology0.75896565
84MP0004130_abnormal_muscle_cell0.75716263
85MP0003866_abnormal_defecation0.75467169
86MP0002398_abnormal_bone_marrow0.74367651
87MP0000751_myopathy0.74123044
88MP0000716_abnormal_immune_system0.73887192
89MP0003137_abnormal_impulse_conducting0.73542460
90MP0010155_abnormal_intestine_physiology0.69806140
91MP0003693_abnormal_embryo_hatching0.69542296
92MP0008995_early_reproductive_senescence0.69301494
93MP0001845_abnormal_inflammatory_respons0.69168247
94MP0002254_reproductive_system_inflammat0.67438669
95MP0002909_abnormal_adrenal_gland0.67335700
96MP0002429_abnormal_blood_cell0.66900907
97MP0009764_decreased_sensitivity_to0.65471103
98MP0003045_fibrosis0.65087037
99MP0001764_abnormal_homeostasis0.64524139
100MP0003191_abnormal_cellular_cholesterol0.63049440

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)5.21132687
2Testicular atrophy (HP:0000029)5.19399258
3Dyschromatopsia (HP:0007641)5.07012739
4Renal Fanconi syndrome (HP:0001994)4.40930082
5Type 2 muscle fiber atrophy (HP:0003554)4.29644247
6Mesangial abnormality (HP:0001966)4.26698098
7Congenital stationary night blindness (HP:0007642)4.22540870
8Rib fusion (HP:0000902)4.01645243
9Decreased electroretinogram (ERG) amplitude (HP:0000654)3.93825327
10Increased hepatocellular lipid droplets (HP:0006565)3.93317092
11Facial diplegia (HP:0001349)3.87294202
12Stomatitis (HP:0010280)3.87256790
13Lipid accumulation in hepatocytes (HP:0006561)3.77968543
14Muscle fiber atrophy (HP:0100295)3.74629132
15Decreased central vision (HP:0007663)3.61064021
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.48786904
17Increased intramyocellular lipid droplets (HP:0012240)3.45475435
18Popliteal pterygium (HP:0009756)3.43915962
19Poikiloderma (HP:0001029)3.33680680
20Rectal fistula (HP:0100590)3.25948119
21Rectovaginal fistula (HP:0000143)3.25948119
22Amniotic constriction ring (HP:0009775)3.21000644
23Abnormality of placental membranes (HP:0011409)3.21000644
24Aplasia of the musculature (HP:0100854)3.20302445
25Prolonged partial thromboplastin time (HP:0003645)3.12499138
26Increased muscle lipid content (HP:0009058)3.08093281
27Abnormal albumin level (HP:0012116)3.07919382
28Hypoalbuminemia (HP:0003073)3.07919382
29Abnormality of the intrinsic pathway (HP:0010989)3.07714454
30Reduced antithrombin III activity (HP:0001976)3.03009875
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.01655852
32Fetal akinesia sequence (HP:0001989)2.92252342
33Akinesia (HP:0002304)2.90373190
34Exertional dyspnea (HP:0002875)2.89614870
35Neonatal respiratory distress (HP:0002643)2.89276825
36Bony spicule pigmentary retinopathy (HP:0007737)2.88616532
37Abnormal drinking behavior (HP:0030082)2.85881882
38Polydipsia (HP:0001959)2.85881882
39Vaginal fistula (HP:0004320)2.82011351
40Intestinal fistula (HP:0100819)2.80873733
41Squamous cell carcinoma (HP:0002860)2.78161405
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72632703
43Patellar aplasia (HP:0006443)2.70562607
44Myotonia (HP:0002486)2.65968948
45Abnormality of the costochondral junction (HP:0000919)2.62325653
46IgG deficiency (HP:0004315)2.61908386
47Joint hemorrhage (HP:0005261)2.56255581
48Type I transferrin isoform profile (HP:0003642)2.55963967
49Aplasia/Hypoplasia of the patella (HP:0006498)2.55557966
50Aplasia/Hypoplasia involving the musculature (HP:0001460)2.54568487
51Chorioretinal atrophy (HP:0000533)2.53985615
52Abnormality of renal resorption (HP:0011038)2.48131335
53Hypophosphatemic rickets (HP:0004912)2.44268550
54Polyuria (HP:0000103)2.43328326
55Choroideremia (HP:0001139)2.34576405
56Annular pancreas (HP:0001734)2.33809015
57Increased IgM level (HP:0003496)2.32877280
58Mitochondrial inheritance (HP:0001427)2.30314292
59Macular degeneration (HP:0000608)2.26192785
60Absent thumb (HP:0009777)2.23911521
61Short chin (HP:0000331)2.18119095
62Respiratory difficulties (HP:0002880)2.14987274
63Premature graying of hair (HP:0002216)2.13828916
64Increased CSF lactate (HP:0002490)2.13400608
65Abnormality of urine glucose concentration (HP:0011016)2.12707071
66Glycosuria (HP:0003076)2.12707071
67Pendular nystagmus (HP:0012043)2.10352170
68Facial hemangioma (HP:0000329)2.07663712
69Abnormality of the prostate (HP:0008775)2.03037823
70Abnormal urine output (HP:0012590)2.01154796
71Aplastic anemia (HP:0001915)2.00507677
72Generalized aminoaciduria (HP:0002909)1.99863516
73Malignant hyperthermia (HP:0002047)1.99412240
74Molar tooth sign on MRI (HP:0002419)1.95626915
75Abnormality of midbrain morphology (HP:0002418)1.95626915
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95402716
77Abnormal protein N-linked glycosylation (HP:0012347)1.95402716
78Abnormal protein glycosylation (HP:0012346)1.95402716
79Abnormal glycosylation (HP:0012345)1.95402716
80Hepatocellular necrosis (HP:0001404)1.94646935
81Methylmalonic aciduria (HP:0012120)1.92973001
82Abnormality of the hepatic vasculature (HP:0006707)1.92417265
83Increased serum lactate (HP:0002151)1.90965925
84Optic disc pallor (HP:0000543)1.89064385
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88842926
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88842926
87Methylmalonic acidemia (HP:0002912)1.87813252
88Hypoproteinemia (HP:0003075)1.83227016
89Diminished movement (HP:0002374)1.82738981
90Hemorrhage of the eye (HP:0011885)1.81874105
91Pustule (HP:0200039)1.81639989
92Abolished electroretinogram (ERG) (HP:0000550)1.81024329
93Hypoplasia of the pons (HP:0012110)1.80733781
94Abnormal rod and cone electroretinograms (HP:0008323)1.80582917
95Abnormality of the pons (HP:0007361)1.78776847
96Abnormality of alanine metabolism (HP:0010916)1.77024856
97Hyperalaninemia (HP:0003348)1.77024856
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77024856
99Abnormality of male internal genitalia (HP:0000022)1.74462580
100Elevated erythrocyte sedimentation rate (HP:0003565)1.73437073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.86899737
2TIE14.55813930
3WNK43.76219757
4TLK13.47247744
5BCKDK2.87801431
6ADRBK22.82863879
7ZAK2.72925703
8MAP4K22.54038893
9GRK12.43783245
10TAOK32.37887817
11TEC2.28658249
12MAP4K12.01381110
13NUAK11.96868907
14GRK61.94014569
15OXSR11.90536337
16KDR1.89686192
17TESK21.86897781
18STK391.83954814
19BMPR1B1.70985869
20MUSK1.70003068
21VRK21.60984642
22ITK1.54825880
23MATK1.54486957
24IKBKB1.42682394
25FES1.40354823
26STK161.33705214
27FRK1.25942268
28CSNK1G31.24053594
29NTRK11.21853851
30TRIM281.21068367
31BTK1.19908770
32BLK1.19444916
33SYK1.16029630
34ADRBK11.15277424
35CSNK1G21.08825049
36SCYL21.04114900
37WNK31.01146691
38MAP2K20.98761403
39CSNK1A1L0.97917433
40PRKCQ0.94701461
41DAPK20.94150115
42CSNK1G10.93074825
43ZAP700.91281967
44IKBKE0.87597519
45CSF1R0.87316865
46VRK10.85814825
47PINK10.79358875
48CSK0.77277156
49PIK3CA0.74746890
50CAMKK20.70911636
51MKNK10.70503377
52PHKG20.68358482
53PHKG10.68358482
54RPS6KA50.68172429
55TBK10.67466080
56KIT0.67423177
57MAPKAPK50.66254770
58DYRK20.65598405
59OBSCN0.65402108
60TAF10.61896949
61LCK0.61574232
62GRK50.60284498
63MAPKAPK30.60082189
64INSRR0.59173442
65LYN0.58963196
66TNK20.58926364
67TGFBR10.57485189
68ACVR1B0.56784997
69TXK0.55752159
70DAPK10.55289442
71MST40.54884653
72EPHA30.51055895
73MAP3K140.48023140
74NME10.47887830
75MAP2K60.46605313
76SRPK10.45806188
77CCNB10.42262562
78CSNK1D0.42236696
79FLT30.40601576
80ATR0.40387768
81MAPK130.39108284
82MKNK20.38861136
83IGF1R0.38348137
84NEK20.37228871
85CHUK0.37089803
86PRKCA0.34507051
87MAPK70.34287262
88AURKA0.34196124
89CDK80.33698655
90WNK10.32904482
91HCK0.32584211
92CDK190.32568637
93PTK2B0.32000611
94ERBB20.31767880
95PIK3CG0.30922701
96PRKACA0.28631965
97PRKCD0.27409138
98CDK40.26500916
99CHEK20.24345371
100SIK20.21712342

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.17541886
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.02524151
3Primary immunodeficiency_Homo sapiens_hsa053403.52953667
4Sulfur relay system_Homo sapiens_hsa041222.79338400
5Asthma_Homo sapiens_hsa053102.65124224
6RNA polymerase_Homo sapiens_hsa030202.44153583
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.39767949
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23939955
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20716769
10Allograft rejection_Homo sapiens_hsa053302.18966848
11Autoimmune thyroid disease_Homo sapiens_hsa053202.09967992
12Proteasome_Homo sapiens_hsa030501.89828467
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88481822
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86414640
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85100709
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79252349
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.74635694
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71195188
19Graft-versus-host disease_Homo sapiens_hsa053321.67060047
20Selenocompound metabolism_Homo sapiens_hsa004501.59226818
21Linoleic acid metabolism_Homo sapiens_hsa005911.52909187
22Fanconi anemia pathway_Homo sapiens_hsa034601.51851931
23Oxidative phosphorylation_Homo sapiens_hsa001901.46764302
24Rheumatoid arthritis_Homo sapiens_hsa053231.25416755
25Homologous recombination_Homo sapiens_hsa034401.22423501
26Parkinsons disease_Homo sapiens_hsa050121.21821513
27Phototransduction_Homo sapiens_hsa047441.19950876
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.18399516
29Type I diabetes mellitus_Homo sapiens_hsa049401.18264828
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17852803
31Basal transcription factors_Homo sapiens_hsa030221.16073386
32One carbon pool by folate_Homo sapiens_hsa006701.15495893
33Taste transduction_Homo sapiens_hsa047421.14217618
34Antigen processing and presentation_Homo sapiens_hsa046121.13277263
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08550677
36Hematopoietic cell lineage_Homo sapiens_hsa046401.06843471
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00795045
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98393622
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97152363
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92879323
41T cell receptor signaling pathway_Homo sapiens_hsa046600.89614998
42RNA degradation_Homo sapiens_hsa030180.86378395
43Ribosome_Homo sapiens_hsa030100.83701276
44Ovarian steroidogenesis_Homo sapiens_hsa049130.83369313
45Sulfur metabolism_Homo sapiens_hsa009200.81616543
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81357440
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80005282
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79850062
49Vitamin digestion and absorption_Homo sapiens_hsa049770.79323256
50Pyrimidine metabolism_Homo sapiens_hsa002400.78963298
51Chemical carcinogenesis_Homo sapiens_hsa052040.78045616
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77848190
53Circadian rhythm_Homo sapiens_hsa047100.76965254
54Tryptophan metabolism_Homo sapiens_hsa003800.76027895
55Nicotine addiction_Homo sapiens_hsa050330.75385107
56Purine metabolism_Homo sapiens_hsa002300.73935666
57Arachidonic acid metabolism_Homo sapiens_hsa005900.73898090
58Viral myocarditis_Homo sapiens_hsa054160.73443091
59Peroxisome_Homo sapiens_hsa041460.70890747
60Sphingolipid metabolism_Homo sapiens_hsa006000.68176156
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.67142192
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66527754
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.66481738
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64969447
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64137016
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61950742
67Staphylococcus aureus infection_Homo sapiens_hsa051500.59500971
68Ether lipid metabolism_Homo sapiens_hsa005650.59131583
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58611320
70Protein export_Homo sapiens_hsa030600.58460111
71Nitrogen metabolism_Homo sapiens_hsa009100.57767467
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57580626
73Alzheimers disease_Homo sapiens_hsa050100.54559634
74Systemic lupus erythematosus_Homo sapiens_hsa053220.54327366
75Metabolic pathways_Homo sapiens_hsa011000.52018445
76Lysosome_Homo sapiens_hsa041420.51423488
77Cardiac muscle contraction_Homo sapiens_hsa042600.51205253
78N-Glycan biosynthesis_Homo sapiens_hsa005100.50366909
79Huntingtons disease_Homo sapiens_hsa050160.50112788
80Base excision repair_Homo sapiens_hsa034100.49815586
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45973690
82Propanoate metabolism_Homo sapiens_hsa006400.44439443
83Calcium signaling pathway_Homo sapiens_hsa040200.43075202
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.41906096
85Nucleotide excision repair_Homo sapiens_hsa034200.41844385
86Non-homologous end-joining_Homo sapiens_hsa034500.40988007
87Collecting duct acid secretion_Homo sapiens_hsa049660.35474283
88Salivary secretion_Homo sapiens_hsa049700.33537591
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32880794
90Glutathione metabolism_Homo sapiens_hsa004800.32859091
91RNA transport_Homo sapiens_hsa030130.31670780
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.31499089
93Caffeine metabolism_Homo sapiens_hsa002320.31487185
94Fructose and mannose metabolism_Homo sapiens_hsa000510.31264856
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30139244
96Morphine addiction_Homo sapiens_hsa050320.27100316
97Retinol metabolism_Homo sapiens_hsa008300.26267961
98Fatty acid degradation_Homo sapiens_hsa000710.23845160
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23745740
100Fat digestion and absorption_Homo sapiens_hsa049750.23064457

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »