RPL17P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)9.06459113
2ribosomal small subunit biogenesis (GO:0042274)8.48602027
3viral transcription (GO:0019083)8.21674991
4translational termination (GO:0006415)7.83440501
5translational elongation (GO:0006414)6.51900375
6ribosomal small subunit assembly (GO:0000028)6.49428428
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.43679515
8cotranslational protein targeting to membrane (GO:0006613)6.39244372
9protein targeting to ER (GO:0045047)6.36822242
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.14499845
11protein localization to endoplasmic reticulum (GO:0070972)5.96273024
12cellular protein complex disassembly (GO:0043624)5.91836472
13viral life cycle (GO:0019058)5.90337343
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.74955265
15behavioral response to nicotine (GO:0035095)5.56803239
16substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.15782057
17substrate-independent telencephalic tangential migration (GO:0021826)5.15782057
18protein complex disassembly (GO:0043241)5.15184838
19macromolecular complex disassembly (GO:0032984)4.93211533
20translational initiation (GO:0006413)4.84190610
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.77891064
22somite development (GO:0061053)4.77854700
23nonmotile primary cilium assembly (GO:0035058)4.73873005
24pattern specification involved in kidney development (GO:0061004)4.55770913
25protein targeting to membrane (GO:0006612)4.53102547
26cell proliferation in forebrain (GO:0021846)4.45787785
27segment specification (GO:0007379)3.98384902
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.95939098
29nuclear-transcribed mRNA catabolic process (GO:0000956)3.93864358
30tongue development (GO:0043586)3.86857572
31mRNA catabolic process (GO:0006402)3.74839062
32epithelial cilium movement (GO:0003351)3.74450148
33neuron fate determination (GO:0048664)3.66781614
34chaperone-mediated protein transport (GO:0072321)3.64895596
35NADH dehydrogenase complex assembly (GO:0010257)3.64217740
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64217740
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.64217740
38motile cilium assembly (GO:0044458)3.62087196
39ribosomal large subunit biogenesis (GO:0042273)3.61138368
40negative regulation of granulocyte differentiation (GO:0030853)3.46088919
41translation (GO:0006412)3.40459843
42axonal fasciculation (GO:0007413)3.33588015
43protein complex biogenesis (GO:0070271)3.28532546
44RNA catabolic process (GO:0006401)3.26427368
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25762335
46ATP synthesis coupled proton transport (GO:0015986)3.25762335
47ribonucleoprotein complex biogenesis (GO:0022613)3.23219193
48establishment of protein localization to membrane (GO:0090150)3.17872933
49response to pheromone (GO:0019236)3.14168407
50cellular component biogenesis (GO:0044085)3.12167459
51negative regulation of response to food (GO:0032096)3.06924084
52negative regulation of appetite (GO:0032099)3.06924084
53piRNA metabolic process (GO:0034587)3.06806328
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02556383
55body morphogenesis (GO:0010171)3.01185007
56synaptic transmission, cholinergic (GO:0007271)2.99906490
57resolution of meiotic recombination intermediates (GO:0000712)2.99385454
58protein neddylation (GO:0045116)2.97935356
59cilium movement (GO:0003341)2.97627612
60cardiovascular system development (GO:0072358)2.96250748
61mitochondrial respiratory chain complex assembly (GO:0033108)2.95381555
62regulation of cilium movement (GO:0003352)2.92563941
63auditory receptor cell differentiation (GO:0042491)2.88692224
64regulation of action potential (GO:0098900)2.88353752
65protein targeting (GO:0006605)2.83170410
66establishment of mitochondrion localization (GO:0051654)2.81654113
67pyrimidine nucleobase catabolic process (GO:0006208)2.79468777
68protein polyglutamylation (GO:0018095)2.75841234
69embryonic body morphogenesis (GO:0010172)2.75834840
70regulation of microtubule-based movement (GO:0060632)2.73792563
71negative regulation of organelle assembly (GO:1902116)2.72494545
72spinal cord association neuron differentiation (GO:0021527)2.70332943
73DNA methylation involved in gamete generation (GO:0043046)2.69274605
74dendritic spine morphogenesis (GO:0060997)2.67704504
75replication fork processing (GO:0031297)2.67204363
76axonemal dynein complex assembly (GO:0070286)2.67104347
77mitochondrion transport along microtubule (GO:0047497)2.65037983
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.65037983
79head development (GO:0060322)2.64993988
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.63394099
81neuron recognition (GO:0008038)2.62502078
82positive regulation of T cell apoptotic process (GO:0070234)2.61987376
83L-serine metabolic process (GO:0006563)2.60394220
84establishment of protein localization to organelle (GO:0072594)2.55477896
85positive regulation of respiratory burst (GO:0060267)2.54941552
86dentate gyrus development (GO:0021542)2.54172438
87electron transport chain (GO:0022900)2.53371041
88protein localization to membrane (GO:0072657)2.52638929
89nephron tubule morphogenesis (GO:0072078)2.51682131
90nephron epithelium morphogenesis (GO:0072088)2.51682131
91respiratory electron transport chain (GO:0022904)2.51049890
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49733196
93collecting duct development (GO:0072044)2.49083644
94central nervous system myelination (GO:0022010)2.48687714
95axon ensheathment in central nervous system (GO:0032291)2.48687714
96postsynaptic membrane organization (GO:0001941)2.47947520
97hypothalamus development (GO:0021854)2.47603132
98organelle disassembly (GO:1903008)2.44930573
99Sertoli cell development (GO:0060009)2.44898330
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44291738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.15204604
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45484680
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.21060790
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.03502701
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22139804
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.19811186
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.08746043
8EZH2_27294783_Chip-Seq_ESCs_Mouse2.03369741
9VDR_22108803_ChIP-Seq_LS180_Human1.97598968
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94717392
11ZNF274_21170338_ChIP-Seq_K562_Hela1.91231688
12GABP_17652178_ChIP-ChIP_JURKAT_Human1.85684271
13GATA1_26923725_Chip-Seq_HPCs_Mouse1.83238988
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81141810
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81080923
16SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79296277
17RNF2_27304074_Chip-Seq_ESCs_Mouse1.74391540
18REST_21632747_ChIP-Seq_MESCs_Mouse1.73268850
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.69361260
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68853561
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68454589
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57331271
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54604636
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52555720
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52555720
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51449844
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.46245335
28RNF2_27304074_Chip-Seq_NSC_Mouse1.41959784
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41266370
30ERA_21632823_ChIP-Seq_H3396_Human1.39598239
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38054537
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.36315374
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.36055059
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.35139359
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31931546
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31871403
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30305709
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29253662
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28717238
40SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27431365
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26392386
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.26347940
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23949352
44DROSHA_22980978_ChIP-Seq_HELA_Human1.23668894
45CTCF_27219007_Chip-Seq_Bcells_Human1.22542064
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.22271857
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22263057
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21912889
49IRF1_19129219_ChIP-ChIP_H3396_Human1.21707377
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21675535
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20707073
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18518745
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16736337
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16533378
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14745845
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14167721
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13555488
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11658752
59TTF2_22483619_ChIP-Seq_HELA_Human1.11532813
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.09943063
61MYC_18940864_ChIP-ChIP_HL60_Human1.09555608
62NANOG_20526341_ChIP-Seq_ESCs_Human1.09151286
63TAF2_19829295_ChIP-Seq_ESCs_Human1.09117664
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.09093020
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.08700415
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08076398
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06162006
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05134291
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04975421
70FUS_26573619_Chip-Seq_HEK293_Human1.04110480
71NCOR_22424771_ChIP-Seq_293T_Human1.03266167
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02652416
73TP53_22573176_ChIP-Seq_HFKS_Human1.01749721
74OCT4_19829295_ChIP-Seq_ESCs_Human1.01018900
75GBX2_23144817_ChIP-Seq_PC3_Human1.00699671
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00622843
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00241540
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97341519
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96833977
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96833977
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.95708927
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94701078
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94544501
84CTCF_20526341_ChIP-Seq_ESCs_Human0.93871968
85CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93147899
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.93037579
87WDR5_24793694_ChIP-Seq_LNCAP_Human0.92534778
88RAC3_21632823_ChIP-Seq_H3396_Human0.91287108
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.89527005
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89478391
91E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89217798
92MYC_19829295_ChIP-Seq_ESCs_Human0.88783764
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.86229546
94P68_20966046_ChIP-Seq_HELA_Human0.86016012
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85771118
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85573714
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.84424356
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84070621
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82628068
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.82361932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.57168429
2MP0006292_abnormal_olfactory_placode4.96802798
3MP0003122_maternal_imprinting3.61611737
4MP0003787_abnormal_imprinting3.33667768
5MP0008877_abnormal_DNA_methylation2.66257542
6MP0004142_abnormal_muscle_tone2.58263657
7MP0008789_abnormal_olfactory_epithelium2.41853241
8MP0003646_muscle_fatigue2.36705857
9MP0003121_genomic_imprinting2.33279897
10MP0002653_abnormal_ependyma_morphology2.33052350
11MP0000778_abnormal_nervous_system2.24158591
12MP0002234_abnormal_pharynx_morphology2.20110647
13MP0005499_abnormal_olfactory_system2.19247134
14MP0005394_taste/olfaction_phenotype2.19247134
15MP0001293_anophthalmia2.03359945
16MP0005423_abnormal_somatic_nervous1.87779919
17MP0003136_yellow_coat_color1.83358758
18MP0006276_abnormal_autonomic_nervous1.79042844
19MP0003123_paternal_imprinting1.75862805
20MP0001485_abnormal_pinna_reflex1.75268522
21MP0001984_abnormal_olfaction1.74891092
22MP0004885_abnormal_endolymph1.72920294
23MP0005377_hearing/vestibular/ear_phenot1.70719496
24MP0003878_abnormal_ear_physiology1.70719496
25MP0000049_abnormal_middle_ear1.70364391
26MP0002102_abnormal_ear_morphology1.69377527
27MP0001968_abnormal_touch/_nociception1.65180606
28MP0010030_abnormal_orbit_morphology1.63729851
29MP0002638_abnormal_pupillary_reflex1.62511166
30MP0003879_abnormal_hair_cell1.60556063
31MP0001986_abnormal_taste_sensitivity1.55767240
32MP0002733_abnormal_thermal_nociception1.50894711
33MP0000631_abnormal_neuroendocrine_gland1.48562089
34MP0001529_abnormal_vocalization1.47163082
35MP0002163_abnormal_gland_morphology1.44519240
36MP0002837_dystrophic_cardiac_calcinosis1.41892407
37MP0002063_abnormal_learning/memory/cond1.38578674
38MP0002734_abnormal_mechanical_nocicepti1.37310957
39MP0002938_white_spotting1.36608002
40MP0001970_abnormal_pain_threshold1.35359305
41MP0004133_heterotaxia1.34334521
42MP0005084_abnormal_gallbladder_morpholo1.33906801
43MP0009053_abnormal_anal_canal1.33612518
44MP0001348_abnormal_lacrimal_gland1.32163006
45MP0002272_abnormal_nervous_system1.32029574
46MP0005551_abnormal_eye_electrophysiolog1.30622782
47MP0001440_abnormal_grooming_behavior1.29924236
48MP0002557_abnormal_social/conspecific_i1.28629834
49MP0000955_abnormal_spinal_cord1.26671137
50MP0002735_abnormal_chemical_nociception1.25662438
51MP0002572_abnormal_emotion/affect_behav1.24673678
52MP0003938_abnormal_ear_development1.24413838
53MP0003635_abnormal_synaptic_transmissio1.23843170
54MP0001486_abnormal_startle_reflex1.23592052
55MP0002184_abnormal_innervation1.22941680
56MP0004859_abnormal_synaptic_plasticity1.22844374
57MP0000026_abnormal_inner_ear1.22470605
58MP0009745_abnormal_behavioral_response1.22095316
59MP0005195_abnormal_posterior_eye1.19593643
60MP0003942_abnormal_urinary_system1.15696733
61MP0008872_abnormal_physiological_respon1.14481578
62MP0001905_abnormal_dopamine_level1.14172666
63MP0004742_abnormal_vestibular_system1.12985865
64MP0002736_abnormal_nociception_after1.12502743
65MP0005379_endocrine/exocrine_gland_phen1.10814715
66MP0003283_abnormal_digestive_organ1.07748542
67MP0002249_abnormal_larynx_morphology1.06424062
68MP0002095_abnormal_skin_pigmentation1.06044027
69MP0003880_abnormal_central_pattern1.06033263
70MP0002752_abnormal_somatic_nervous1.04881366
71MP0001963_abnormal_hearing_physiology1.03236117
72MP0003890_abnormal_embryonic-extraembry1.00674541
73MP0002233_abnormal_nose_morphology0.99040476
74MP0005645_abnormal_hypothalamus_physiol0.98721888
75MP0002152_abnormal_brain_morphology0.96651356
76MP0001286_abnormal_eye_development0.94638066
77MP0001324_abnormal_eye_pigmentation0.93511393
78MP0005389_reproductive_system_phenotype0.92620065
79MP0002138_abnormal_hepatobiliary_system0.91897209
80MP0004145_abnormal_muscle_electrophysio0.91731529
81MP0002882_abnormal_neuron_morphology0.90408800
82MP0002064_seizures0.89356821
83MP0002160_abnormal_reproductive_system0.89309068
84MP0002067_abnormal_sensory_capabilities0.89175598
85MP0003119_abnormal_digestive_system0.85882129
86MP0008875_abnormal_xenobiotic_pharmacok0.84273495
87MP0006072_abnormal_retinal_apoptosis0.83829972
88MP0003861_abnormal_nervous_system0.82508853
89MP0003937_abnormal_limbs/digits/tail_de0.81996555
90MP0009046_muscle_twitch0.79042446
91MP0003186_abnormal_redox_activity0.78344942
92MP0002822_catalepsy0.77247141
93MP0003755_abnormal_palate_morphology0.75169569
94MP0002116_abnormal_craniofacial_bone0.74828400
95MP0005646_abnormal_pituitary_gland0.73885078
96MP0005174_abnormal_tail_pigmentation0.73538127
97MP0000427_abnormal_hair_cycle0.73143525
98MP0003698_abnormal_male_reproductive0.72209295
99MP0002210_abnormal_sex_determination0.71853162
100MP0004924_abnormal_behavior0.71830604

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.78778868
2Abnormality of cells of the erythroid lineage (HP:0012130)4.97048329
3Septo-optic dysplasia (HP:0100842)4.67683210
4Molar tooth sign on MRI (HP:0002419)4.07218656
5Abnormality of midbrain morphology (HP:0002418)4.07218656
6Macrocytic anemia (HP:0001972)3.98734653
7Pancreatic fibrosis (HP:0100732)3.71275156
8Absent/shortened dynein arms (HP:0200106)3.40740845
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.40740845
10Abnormal hemoglobin (HP:0011902)3.33275420
11Acute necrotizing encephalopathy (HP:0006965)3.22154316
12Abnormal number of erythroid precursors (HP:0012131)3.21367539
13Pancreatic cysts (HP:0001737)3.16008768
14Stenosis of the external auditory canal (HP:0000402)3.13780167
15Pallor (HP:0000980)3.11526418
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92631448
17Maternal diabetes (HP:0009800)2.92501766
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88910868
19Abnormal mitochondria in muscle tissue (HP:0008316)2.85691308
20Absent thumb (HP:0009777)2.81346064
21Aplasia/Hypoplasia of the spleen (HP:0010451)2.79208319
22Abnormal ciliary motility (HP:0012262)2.78532035
23Acute encephalopathy (HP:0006846)2.77922881
24Abnormality of the labia minora (HP:0012880)2.75763883
25Agitation (HP:0000713)2.75339542
26Rib fusion (HP:0000902)2.73767966
27Abnormal rod and cone electroretinograms (HP:0008323)2.72973913
28Nephronophthisis (HP:0000090)2.72546426
29Medial flaring of the eyebrow (HP:0010747)2.72333297
30Abnormal respiratory motile cilium morphology (HP:0005938)2.72330979
31Abnormal respiratory epithelium morphology (HP:0012253)2.72330979
32Asplenia (HP:0001746)2.69939566
33Supernumerary spleens (HP:0009799)2.69645776
34Mitochondrial inheritance (HP:0001427)2.68850818
35Absent septum pellucidum (HP:0001331)2.68775139
36True hermaphroditism (HP:0010459)2.68513674
37Pendular nystagmus (HP:0012043)2.64392774
38Polyphagia (HP:0002591)2.62755663
39Optic nerve hypoplasia (HP:0000609)2.58127638
40Anencephaly (HP:0002323)2.57679733
41Cystic liver disease (HP:0006706)2.56895849
42Depressed nasal ridge (HP:0000457)2.53408869
43Colon cancer (HP:0003003)2.50612940
44Progressive macrocephaly (HP:0004481)2.50383652
45Abnormality of reticulocytes (HP:0004312)2.40557110
46Growth hormone deficiency (HP:0000824)2.39801931
47Gait imbalance (HP:0002141)2.36949509
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32049609
49Increased CSF lactate (HP:0002490)2.29835384
50Lipid accumulation in hepatocytes (HP:0006561)2.26136081
51Abnormality of the renal medulla (HP:0100957)2.23362665
52Increased hepatocellular lipid droplets (HP:0006565)2.23302452
53Anophthalmia (HP:0000528)2.21072003
54Abnormal respiratory motile cilium physiology (HP:0012261)2.19207902
55Congenital stationary night blindness (HP:0007642)2.17750913
56Oligodactyly (hands) (HP:0001180)2.17514389
57Congenital primary aphakia (HP:0007707)2.14936762
58Sclerocornea (HP:0000647)2.10315701
59Tubular atrophy (HP:0000092)2.07166965
60Thyroid-stimulating hormone excess (HP:0002925)2.04581514
61Abnormality of the septum pellucidum (HP:0007375)2.03475521
62Abnormality of the diencephalon (HP:0010662)2.02384150
63Adrenal hypoplasia (HP:0000835)2.01840591
64Poor suck (HP:0002033)2.01502546
65Type II lissencephaly (HP:0007260)2.01217627
66Hip dysplasia (HP:0001385)2.01051051
67Hyperthyroidism (HP:0000836)1.99477793
68Polydipsia (HP:0001959)1.99213403
69Abnormal drinking behavior (HP:0030082)1.99213403
70Abnormal eating behavior (HP:0100738)1.99106632
71Oligodactyly (HP:0012165)1.99029095
72Nephrogenic diabetes insipidus (HP:0009806)1.98243064
73Osteomalacia (HP:0002749)1.97954420
74Increased intramyocellular lipid droplets (HP:0012240)1.97337717
75Renal Fanconi syndrome (HP:0001994)1.96628456
76Focal motor seizures (HP:0011153)1.96130864
77Pachygyria (HP:0001302)1.96083867
78Holoprosencephaly (HP:0001360)1.94770674
79Partial duplication of thumb phalanx (HP:0009944)1.94372289
80Postaxial foot polydactyly (HP:0001830)1.92929371
81Hyperventilation (HP:0002883)1.92196852
82Chronic hepatic failure (HP:0100626)1.91360583
83Abnormality of renal resorption (HP:0011038)1.90991930
84Cerebral edema (HP:0002181)1.90744691
85Abnormal number of incisors (HP:0011064)1.87302159
86Poor coordination (HP:0002370)1.85191192
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85049339
88Lissencephaly (HP:0001339)1.84183699
89Hepatocellular necrosis (HP:0001404)1.83179770
90Abnormality of DNA repair (HP:0003254)1.82524208
91Renal dysplasia (HP:0000110)1.81423338
92Myokymia (HP:0002411)1.81201092
93Optic disc pallor (HP:0000543)1.80637925
94Elfin facies (HP:0004428)1.80252058
95Flat capital femoral epiphysis (HP:0003370)1.79960249
96Triphalangeal thumb (HP:0001199)1.76527218
97Renovascular hypertension (HP:0100817)1.75879341
98Vaginal atresia (HP:0000148)1.75196682
99Hypoplasia of the ulna (HP:0003022)1.74709232
100Increased muscle lipid content (HP:0009058)1.73253198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.29492227
2DYRK22.64558951
3STK392.62303589
4STK162.58632593
5EPHB22.55073936
6ADRBK22.41791884
7PINK12.40800573
8CASK2.33435336
9MAP3K92.32680774
10LRRK22.07763184
11GRK12.02634098
12MAP3K111.94075148
13CDC71.82623200
14TYRO31.81294395
15WNK11.75564230
16MAP3K41.73965163
17MAP4K21.69451312
18CDK191.67123239
19BCKDK1.53257417
20NTRK21.53143211
21PAK31.37363481
22MARK11.36763384
23PAK61.34641493
24MAPK131.33703481
25WNK31.31886392
26NUAK11.31783642
27TNIK1.28628360
28CAMKK21.27394806
29BRAF1.26877897
30PRKCG1.23624023
31CAMK1D1.21418870
32PIK3CA1.15408127
33LIMK11.13907859
34PHKG11.11152205
35PHKG21.11152205
36CAMK11.10916069
37PRKD31.06163163
38PLK21.06151029
39PRKCI1.03049649
40CAMKK11.02514438
41DAPK31.00836342
42PIM21.00342405
43RPS6KA20.99944124
44VRK20.98157910
45SGK4940.96492203
46SGK2230.96492203
47TIE10.95900514
48TAOK30.95182787
49CAMK1G0.94960119
50MAP2K70.91280059
51PRKCH0.89730970
52RPS6KA60.87767349
53STK110.86997338
54OXSR10.85715637
55ZAK0.82586068
56AURKA0.81068781
57PASK0.78792357
58MARK20.77662499
59MKNK20.76994185
60PRKCZ0.75841135
61INSRR0.75797399
62PRKCQ0.74279588
63DYRK1B0.73695573
64ADRBK10.72510085
65RPS6KC10.70741142
66RPS6KL10.70741142
67ARAF0.69573050
68TLK10.65327140
69MOS0.63750173
70CSNK1G20.62457517
71PRKACA0.61110997
72AURKB0.60791149
73BMPR1B0.60297589
74ABL20.59707734
75MAP3K120.58046203
76MAP2K40.57067313
77CAMK2A0.55335289
78FRK0.53661299
79CSNK1G30.53287073
80CAMK40.52799163
81MARK30.52188104
82IRAK40.51190507
83PRKCE0.50994843
84CSNK2A20.49358637
85CSNK1E0.49232311
86KSR10.48571067
87PNCK0.45254046
88CDK140.44988893
89MINK10.44720270
90EPHA40.43830151
91PLK40.43192979
92CSNK1G10.42781730
93ERBB20.42243973
94RPS6KA10.41778591
95CDK50.40918284
96ROCK10.40503481
97MAP2K20.38325633
98CCNB10.38026772
99AKT10.37331629
100CDK11A0.36618556

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.17854111
2Oxidative phosphorylation_Homo sapiens_hsa001903.72581694
3Parkinsons disease_Homo sapiens_hsa050123.14040303
4Cardiac muscle contraction_Homo sapiens_hsa042602.91837916
5Huntingtons disease_Homo sapiens_hsa050162.43630516
6Alzheimers disease_Homo sapiens_hsa050102.19762053
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14785556
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12890076
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12380136
10Linoleic acid metabolism_Homo sapiens_hsa005912.03832692
11Nicotine addiction_Homo sapiens_hsa050331.92861816
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87441061
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85349986
14Phototransduction_Homo sapiens_hsa047441.62321082
15RNA polymerase_Homo sapiens_hsa030201.54050887
16Protein export_Homo sapiens_hsa030601.50099905
17Basal cell carcinoma_Homo sapiens_hsa052171.45867827
18Tryptophan metabolism_Homo sapiens_hsa003801.44795795
19Fanconi anemia pathway_Homo sapiens_hsa034601.40884400
20RNA degradation_Homo sapiens_hsa030181.37018857
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29133778
22Steroid biosynthesis_Homo sapiens_hsa001001.26210992
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24884533
24Fat digestion and absorption_Homo sapiens_hsa049751.24241237
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23097017
26One carbon pool by folate_Homo sapiens_hsa006701.21286603
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21055684
28Morphine addiction_Homo sapiens_hsa050321.20126744
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19296071
30Nitrogen metabolism_Homo sapiens_hsa009101.16660108
31Sulfur relay system_Homo sapiens_hsa041221.12816795
32Butanoate metabolism_Homo sapiens_hsa006501.12069329
33Olfactory transduction_Homo sapiens_hsa047401.10141101
34Ether lipid metabolism_Homo sapiens_hsa005651.09996357
35Basal transcription factors_Homo sapiens_hsa030221.09794140
36Peroxisome_Homo sapiens_hsa041461.05467986
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01847181
38Hedgehog signaling pathway_Homo sapiens_hsa043401.00854352
39Insulin secretion_Homo sapiens_hsa049110.98902696
40Homologous recombination_Homo sapiens_hsa034400.97965613
41Fatty acid degradation_Homo sapiens_hsa000710.96969539
42Propanoate metabolism_Homo sapiens_hsa006400.96423268
43Dorso-ventral axis formation_Homo sapiens_hsa043200.94606774
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87724987
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.87127757
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85952984
47beta-Alanine metabolism_Homo sapiens_hsa004100.85062759
48Axon guidance_Homo sapiens_hsa043600.84336734
49Chemical carcinogenesis_Homo sapiens_hsa052040.81783427
50Folate biosynthesis_Homo sapiens_hsa007900.79509863
51Arachidonic acid metabolism_Homo sapiens_hsa005900.78743323
52Ovarian steroidogenesis_Homo sapiens_hsa049130.78485388
53Caffeine metabolism_Homo sapiens_hsa002320.75120553
54Mismatch repair_Homo sapiens_hsa034300.73904266
55Hippo signaling pathway_Homo sapiens_hsa043900.71079166
56Taste transduction_Homo sapiens_hsa047420.70838122
57Glutamatergic synapse_Homo sapiens_hsa047240.69775551
58Retinol metabolism_Homo sapiens_hsa008300.66156635
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65921099
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65824954
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65375413
62Nucleotide excision repair_Homo sapiens_hsa034200.65326010
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64912297
64Arginine and proline metabolism_Homo sapiens_hsa003300.64479286
65GABAergic synapse_Homo sapiens_hsa047270.62524422
66Metabolic pathways_Homo sapiens_hsa011000.61429995
67Salivary secretion_Homo sapiens_hsa049700.60361853
68Starch and sucrose metabolism_Homo sapiens_hsa005000.59989623
69Glycerolipid metabolism_Homo sapiens_hsa005610.59980842
70Purine metabolism_Homo sapiens_hsa002300.58119547
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55657118
72Proteasome_Homo sapiens_hsa030500.54829482
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54251212
74Pyrimidine metabolism_Homo sapiens_hsa002400.53280105
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52500204
76Notch signaling pathway_Homo sapiens_hsa043300.49002316
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48174816
78Asthma_Homo sapiens_hsa053100.47068394
79Pyruvate metabolism_Homo sapiens_hsa006200.46859061
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46327734
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.46244833
82Circadian entrainment_Homo sapiens_hsa047130.45000006
83Synaptic vesicle cycle_Homo sapiens_hsa047210.44012741
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42597581
85Collecting duct acid secretion_Homo sapiens_hsa049660.40180063
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.38025027
87Oxytocin signaling pathway_Homo sapiens_hsa049210.36355867
88DNA replication_Homo sapiens_hsa030300.35552448
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.34771398
90Cholinergic synapse_Homo sapiens_hsa047250.34454989
91Gastric acid secretion_Homo sapiens_hsa049710.33859604
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.32300780
93Pancreatic secretion_Homo sapiens_hsa049720.32143021
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32040602
95Thyroid hormone synthesis_Homo sapiens_hsa049180.31828982
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30995147
97Serotonergic synapse_Homo sapiens_hsa047260.30546930
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28377008
99Bile secretion_Homo sapiens_hsa049760.27960783
100Melanogenesis_Homo sapiens_hsa049160.27621275

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