ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.92244986
2	ribosomal small subunit biogenesis (GO:0042274)	7.80522649
3	translational termination (GO:0006415)	7.46075656
4	maturation of SSU-rRNA (GO:0030490)	6.55856426
5	ribosomal small subunit assembly (GO:0000028)	6.48344231
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.44039971
7	protein targeting to ER (GO:0045047)	6.37671448
8	cotranslational protein targeting to membrane (GO:0006613)	6.35017079
9	translational elongation (GO:0006414)	6.30911185
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.17224648
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.15334409
12	protein localization to endoplasmic reticulum (GO:0070972)	5.98132808
13	chaperone-mediated protein transport (GO:0072321)	5.72813782
14	viral life cycle (GO:0019058)	5.65095067
15	cellular protein complex disassembly (GO:0043624)	5.48292192
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.37042396
17	ribosomal large subunit biogenesis (GO:0042273)	4.96039714
18	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.94868935
19	substrate-independent telencephalic tangential migration (GO:0021826)	4.94868935
20	translational initiation (GO:0006413)	4.77415724
21	protein complex disassembly (GO:0043241)	4.61523592
22	GTP biosynthetic process (GO:0006183)	4.56368365
23	protein targeting to membrane (GO:0006612)	4.43630802
24	exogenous drug catabolic process (GO:0042738)	4.38025193
25	macromolecular complex disassembly (GO:0032984)	4.34540381
26	behavioral response to nicotine (GO:0035095)	4.27201848
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.23451261
28	ATP synthesis coupled proton transport (GO:0015986)	4.23451261
29	ribonucleoprotein complex biogenesis (GO:0022613)	4.18971912
30	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.12234627
31	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.10386517
32	homocysteine metabolic process (GO:0050667)	4.03973413
33	translation (GO:0006412)	4.00386461
34	somite development (GO:0061053)	3.95127777
35	L-serine metabolic process (GO:0006563)	3.89841774
36	UTP biosynthetic process (GO:0006228)	3.89700214
37	drug catabolic process (GO:0042737)	3.89519182
38	cellular component biogenesis (GO:0044085)	3.78215797
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.75975088
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.67200065
41	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.65302053
42	UTP metabolic process (GO:0046051)	3.64266515
43	water-soluble vitamin biosynthetic process (GO:0042364)	3.63405481
44	motile cilium assembly (GO:0044458)	3.61899663
45	intracellular protein transmembrane import (GO:0044743)	3.59267175
46	mRNA catabolic process (GO:0006402)	3.56990984
47	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.54532498
48	protein complex biogenesis (GO:0070271)	3.53331846
49	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.48835719
50	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.45033755
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42926048
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42926048
53	NADH dehydrogenase complex assembly (GO:0010257)	3.42926048
54	respiratory electron transport chain (GO:0022904)	3.40612860
55	positive regulation of T cell apoptotic process (GO:0070234)	3.38827740
56	electron transport chain (GO:0022900)	3.38154553
57	oxidative demethylation (GO:0070989)	3.31798377
58	CTP metabolic process (GO:0046036)	3.28768834
59	CTP biosynthetic process (GO:0006241)	3.28768834
60	RNA catabolic process (GO:0006401)	3.26928505
61	cell proliferation in forebrain (GO:0021846)	3.26888911
62	nonmotile primary cilium assembly (GO:0035058)	3.26068554
63	icosanoid secretion (GO:0032309)	3.23470046
64	arachidonic acid secretion (GO:0050482)	3.23470046
65	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20348891
66	regulation of immunoglobulin secretion (GO:0051023)	3.16066333
67	establishment of protein localization to membrane (GO:0090150)	3.15102837
68	omega-hydroxylase P450 pathway (GO:0097267)	3.11615221
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.11005816
70	serine family amino acid catabolic process (GO:0009071)	3.06972335
71	glycerophospholipid catabolic process (GO:0046475)	3.05852249
72	cellular biogenic amine catabolic process (GO:0042402)	3.04494972
73	amine catabolic process (GO:0009310)	3.04494972
74	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.03856690
75	cardiovascular system development (GO:0072358)	3.01421493
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.01033537
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.01033537
78	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00305563
79	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99745742
80	tongue development (GO:0043586)	2.99487515
81	myoblast migration (GO:0051451)	2.97071008
82	short-term memory (GO:0007614)	2.92395616
83	rRNA processing (GO:0006364)	2.91052848
84	rRNA metabolic process (GO:0016072)	2.88553720
85	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.87708477
86	protein targeting (GO:0006605)	2.87619988
87	pattern specification involved in kidney development (GO:0061004)	2.86602063
88	epoxygenase P450 pathway (GO:0019373)	2.85646588
89	fatty acid derivative transport (GO:1901571)	2.82226469
90	icosanoid transport (GO:0071715)	2.82226469
91	establishment of protein localization to organelle (GO:0072594)	2.82188472
92	segment specification (GO:0007379)	2.80213109
93	negative regulation of B cell apoptotic process (GO:0002903)	2.79899480
94	protein transmembrane transport (GO:0071806)	2.76544761
95	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.74335842
96	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.72658721
97	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.72368268
98	pseudouridine synthesis (GO:0001522)	2.71270935
99	axonemal dynein complex assembly (GO:0070286)	2.70538282
100	glyoxylate metabolic process (GO:0046487)	2.69432842

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.51899804
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.19427439
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.13390069
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.05765032
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.92198932
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.76685417
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46556365
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.44682888
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.31303847
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.21923579
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.20958143
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.15657896
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.14229271
14	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.11841339
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08772262
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.06954627
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.01388209
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91112601
19	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.73994790
20	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.71977202
21	VDR_22108803_ChIP-Seq_LS180_Human	1.70771747
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.65636827
23	TTF2_22483619_ChIP-Seq_HELA_Human	1.65370797
24	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.64868004
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61540073
26	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.57846222
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.55115812
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54320178
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.51690223
30	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.51552589
31	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.45679125
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.43814119
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41248599
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41096383
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39464167
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.38887739
37	EWS_26573619_Chip-Seq_HEK293_Human	1.38876145
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38377627
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.36264390
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34242891
41	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.33141467
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.31634425
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31496631
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30577531
45	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.30100532
46	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.28999277
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.26092144
48	ERA_21632823_ChIP-Seq_H3396_Human	1.25027148
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24587343
50	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.23251120
51	XRN2_22483619_ChIP-Seq_HELA_Human	1.23093472
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23071276
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22017382
54	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19262079
55	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.17289992
56	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.15210518
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12797272
58	CTCF_27219007_Chip-Seq_Bcells_Human	1.12482223
59	CTCF_20526341_ChIP-Seq_ESCs_Human	1.12472078
60	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10915644
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10699178
62	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10483871
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10445571
64	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10398733
65	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.09240817
66	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.08174179
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.07372081
68	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07220987
69	GABP_19822575_ChIP-Seq_HepG2_Human	1.06626425
70	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.05934941
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05880065
72	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.04629097
73	FUS_26573619_Chip-Seq_HEK293_Human	1.04117964
74	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03483419
75	KDM5A_27292631_Chip-Seq_BREAST_Human	1.03383330
76	NCOR_22424771_ChIP-Seq_293T_Human	1.02659020
77	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.02037552
78	SA1_27219007_Chip-Seq_Bcells_Human	0.99620733
79	MYC_19829295_ChIP-Seq_ESCs_Human	0.98328039
80	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97747123
81	MYC_18940864_ChIP-ChIP_HL60_Human	0.96324730
82	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.96022869
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95792101
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94976935
85	ELK1_19687146_ChIP-ChIP_HELA_Human	0.94560372
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.94232027
87	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.93435356
88	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93423121
89	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92172164
90	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.91900573
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91856976
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90532565
93	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.90361253
94	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.86577088
95	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.86323003
96	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.85939874
97	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.83353424
98	FOXP3_21729870_ChIP-Seq_TREG_Human	0.83051933
99	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.82074388
100	REST_21632747_ChIP-Seq_MESCs_Mouse	0.81888723

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.89764596
2	MP0006292_abnormal_olfactory_placode	5.83262012
3	MP0003122_maternal_imprinting	3.06070742
4	MP0008875_abnormal_xenobiotic_pharmacok	2.68501102
5	MP0010030_abnormal_orbit_morphology	2.65462409
6	MP0001293_anophthalmia	2.55314904
7	MP0004142_abnormal_muscle_tone	2.51575630
8	MP0002837_dystrophic_cardiac_calcinosis	2.45071677
9	MP0005377_hearing/vestibular/ear_phenot	2.42734637
10	MP0003878_abnormal_ear_physiology	2.42734637
11	MP0008789_abnormal_olfactory_epithelium	2.37181140
12	MP0002138_abnormal_hepatobiliary_system	2.19976615
13	MP0008877_abnormal_DNA_methylation	2.11058036
14	MP0009053_abnormal_anal_canal	2.09651808
15	MP0004885_abnormal_endolymph	1.98773444
16	MP0002234_abnormal_pharynx_morphology	1.92549266
17	MP0006276_abnormal_autonomic_nervous	1.90387050
18	MP0008775_abnormal_heart_ventricle	1.89860466
19	MP0000049_abnormal_middle_ear	1.88405075
20	MP0005394_taste/olfaction_phenotype	1.82752606
21	MP0005499_abnormal_olfactory_system	1.82752606
22	MP0005365_abnormal_bile_salt	1.77160623
23	MP0005083_abnormal_biliary_tract	1.77014437
24	MP0003186_abnormal_redox_activity	1.71597841
25	MP0005085_abnormal_gallbladder_physiolo	1.68813848
26	MP0004133_heterotaxia	1.68156950
27	MP0001853_heart_inflammation	1.66807727
28	MP0002102_abnormal_ear_morphology	1.65825348
29	MP0001984_abnormal_olfaction	1.59325889
30	MP0003646_muscle_fatigue	1.51644548
31	MP0008872_abnormal_physiological_respon	1.47081163
32	MP0005084_abnormal_gallbladder_morpholo	1.44705485
33	MP0003959_abnormal_lean_body	1.38266665
34	MP0003121_genomic_imprinting	1.36758021
35	MP0005408_hypopigmentation	1.34650752
36	MP0003938_abnormal_ear_development	1.32072305
37	MP0000604_amyloidosis	1.31102770
38	MP0002697_abnormal_eye_size	1.27047723
39	MP0003195_calcinosis	1.26426233
40	MP0000778_abnormal_nervous_system	1.24104489
41	MP0002653_abnormal_ependyma_morphology	1.23674921
42	MP0004147_increased_porphyrin_level	1.23095866
43	MP0004019_abnormal_vitamin_homeostasis	1.23013423
44	MP0002139_abnormal_hepatobiliary_system	1.21862465
45	MP0002233_abnormal_nose_morphology	1.21571666
46	MP0003252_abnormal_bile_duct	1.20420273
47	MP0000566_synostosis	1.19163319
48	MP0002638_abnormal_pupillary_reflex	1.17771598
49	MP0002160_abnormal_reproductive_system	1.16387504
50	MP0005360_urolithiasis	1.15816448
51	MP0001440_abnormal_grooming_behavior	1.15014367
52	MP0003937_abnormal_limbs/digits/tail_de	1.13370163
53	MP0003942_abnormal_urinary_system	1.12210552
54	MP0001286_abnormal_eye_development	1.12134253
55	MP0004742_abnormal_vestibular_system	1.11347583
56	MP0003011_delayed_dark_adaptation	1.09643482
57	MP0000026_abnormal_inner_ear	1.09371397
58	MP0003879_abnormal_hair_cell	1.08287239
59	MP0002249_abnormal_larynx_morphology	1.06942750
60	MP0002272_abnormal_nervous_system	1.05573444
61	MP0002736_abnormal_nociception_after	1.04696681
62	MP0005195_abnormal_posterior_eye	1.02046788
63	MP0005332_abnormal_amino_acid	1.00736071
64	MP0003638_abnormal_response/metabolism_	0.99795079
65	MP0003787_abnormal_imprinting	0.97873464
66	MP0002876_abnormal_thyroid_physiology	0.95793550
67	MP0001542_abnormal_bone_strength	0.94401957
68	MP0005389_reproductive_system_phenotype	0.92850798
69	MP0005257_abnormal_intraocular_pressure	0.92420345
70	MP0001963_abnormal_hearing_physiology	0.90543880
71	MP0003119_abnormal_digestive_system	0.89897398
72	MP0002210_abnormal_sex_determination	0.88066423
73	MP0000631_abnormal_neuroendocrine_gland	0.85647366
74	MP0001968_abnormal_touch/_nociception	0.84477104
75	MP0001905_abnormal_dopamine_level	0.82537879
76	MP0002184_abnormal_innervation	0.82299548
77	MP0001919_abnormal_reproductive_system	0.82097324
78	MP0005248_abnormal_Harderian_gland	0.82016463
79	MP0002733_abnormal_thermal_nociception	0.79823823
80	MP0009745_abnormal_behavioral_response	0.78319684
81	MP0002752_abnormal_somatic_nervous	0.77892940
82	MP0001529_abnormal_vocalization	0.76270319
83	MP0005448_abnormal_energy_balance	0.75080864
84	MP0002092_abnormal_eye_morphology	0.73613812
85	MP0005551_abnormal_eye_electrophysiolog	0.73350497
86	MP0003315_abnormal_perineum_morphology	0.71751719
87	MP0005646_abnormal_pituitary_gland	0.70141551
88	MP0009046_muscle_twitch	0.69320152
89	MP0002735_abnormal_chemical_nociception	0.69240950
90	MP0005410_abnormal_fertilization	0.69227865
91	MP0003567_abnormal_fetal_cardiomyocyte	0.68298907
92	MP0002063_abnormal_learning/memory/cond	0.67282265
93	MP0009764_decreased_sensitivity_to	0.66282957
94	MP0000647_abnormal_sebaceous_gland	0.66026405
95	MP0002282_abnormal_trachea_morphology	0.65686559
96	MP0001485_abnormal_pinna_reflex	0.65287610
97	MP0004130_abnormal_muscle_cell	0.63132098
98	MP0005167_abnormal_blood-brain_barrier	0.62772829
99	MP0003693_abnormal_embryo_hatching	0.62570351
100	MP0003329_amyloid_beta_deposits	0.61733369

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.12294908
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.83352237
3	Abnormal number of erythroid precursors (HP:0012131)	4.47332341
4	Macrocytic anemia (HP:0001972)	4.28679276
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.84581171
6	Acute necrotizing encephalopathy (HP:0006965)	3.64764199
7	Absent/shortened dynein arms (HP:0200106)	3.52300212
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.52300212
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.41018510
10	Mitochondrial inheritance (HP:0001427)	3.39540275
11	Molar tooth sign on MRI (HP:0002419)	3.29914391
12	Abnormality of midbrain morphology (HP:0002418)	3.29914391
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.23723685
14	Pallor (HP:0000980)	3.12658532
15	Conjugated hyperbilirubinemia (HP:0002908)	3.08521899
16	Abnormal ciliary motility (HP:0012262)	3.05514435
17	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.92849948
18	Rib fusion (HP:0000902)	2.92612543
19	Increased CSF lactate (HP:0002490)	2.90639045
20	Osteomalacia (HP:0002749)	2.88810940
21	Acute encephalopathy (HP:0006846)	2.88325293
22	Progressive macrocephaly (HP:0004481)	2.83268979
23	Stomatitis (HP:0010280)	2.81063907
24	Pancreatic fibrosis (HP:0100732)	2.69866205
25	Increased hepatocellular lipid droplets (HP:0006565)	2.68912598
26	Sclerocornea (HP:0000647)	2.68697847
27	Abnormal respiratory motile cilium physiology (HP:0012261)	2.67768003
28	Lipid accumulation in hepatocytes (HP:0006561)	2.66024338
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.63882676
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.63882676
31	Increased intramyocellular lipid droplets (HP:0012240)	2.63174897
32	Anencephaly (HP:0002323)	2.62796727
33	Absent thumb (HP:0009777)	2.62463122
34	Pancreatic cysts (HP:0001737)	2.60720170
35	Type II lissencephaly (HP:0007260)	2.59976924
36	Hypoplasia of the radius (HP:0002984)	2.58111719
37	Elevated erythrocyte sedimentation rate (HP:0003565)	2.56319795
38	Pendular nystagmus (HP:0012043)	2.46428053
39	Abnormal hemoglobin (HP:0011902)	2.43295001
40	Stenosis of the external auditory canal (HP:0000402)	2.41928524
41	Septo-optic dysplasia (HP:0100842)	2.41110175
42	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.40995788
43	True hermaphroditism (HP:0010459)	2.37361400
44	Cerebral edema (HP:0002181)	2.36363712
45	Hepatocellular necrosis (HP:0001404)	2.36235582
46	Increased muscle lipid content (HP:0009058)	2.30351083
47	Depressed nasal ridge (HP:0000457)	2.27156111
48	Bile duct proliferation (HP:0001408)	2.25366974
49	Abnormal biliary tract physiology (HP:0012439)	2.25366974
50	Abnormality of renal resorption (HP:0011038)	2.24392089
51	Congenital stationary night blindness (HP:0007642)	2.21728011
52	Oligomenorrhea (HP:0000876)	2.21386545
53	Increased serum lactate (HP:0002151)	2.15575290
54	Keratoconus (HP:0000563)	2.15501978
55	Increased corneal curvature (HP:0100692)	2.15501978
56	Triphalangeal thumb (HP:0001199)	2.15490467
57	Nephronophthisis (HP:0000090)	2.14367926
58	Poor suck (HP:0002033)	2.13150930
59	Abnormal number of incisors (HP:0011064)	2.12137528
60	11 pairs of ribs (HP:0000878)	2.10433566
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.09498009
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.09498009
63	Cystic liver disease (HP:0006706)	2.08460273
64	Abnormality of cochlea (HP:0000375)	2.08042138
65	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00873078
66	Hepatic necrosis (HP:0002605)	2.00515944
67	Forearm undergrowth (HP:0009821)	1.98050190
68	Abnormality of reticulocytes (HP:0004312)	1.97487038
69	Abnormal urine phosphate concentration (HP:0012599)	1.95985482
70	3-Methylglutaconic aciduria (HP:0003535)	1.95151254
71	Abnormality of the nasal septum (HP:0000419)	1.93778033
72	Lactic acidosis (HP:0003128)	1.93754508
73	Hyperphosphaturia (HP:0003109)	1.92618918
74	Male pseudohermaphroditism (HP:0000037)	1.91894302
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91883152
76	Optic disc pallor (HP:0000543)	1.88607688
77	Adrenal hypoplasia (HP:0000835)	1.87264804
78	Orchitis (HP:0100796)	1.85686084
79	Complement deficiency (HP:0004431)	1.85566937
80	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.85520167
81	Renal Fanconi syndrome (HP:0001994)	1.84825426
82	Hypobetalipoproteinemia (HP:0003563)	1.84677737
83	Respiratory failure (HP:0002878)	1.83245641
84	Peritonitis (HP:0002586)	1.82786026
85	Hypoplasia of the ulna (HP:0003022)	1.81368548
86	Squamous cell carcinoma (HP:0002860)	1.80449513
87	Abnormality of the 4th metacarpal (HP:0010012)	1.76326647
88	Flat capital femoral epiphysis (HP:0003370)	1.76239186
89	Exercise intolerance (HP:0003546)	1.75593313
90	Anophthalmia (HP:0000528)	1.75314600
91	Abnormality of the renal medulla (HP:0100957)	1.74371925
92	Shawl scrotum (HP:0000049)	1.72764164
93	Fibular hypoplasia (HP:0003038)	1.69427009
94	Lissencephaly (HP:0001339)	1.69112219
95	Ectopic kidney (HP:0000086)	1.68971078
96	Polyphagia (HP:0002591)	1.66989246
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.66796421
98	Cortical visual impairment (HP:0100704)	1.66374894
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.64200796
100	Chronic bronchitis (HP:0004469)	1.63983673

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.27590525
2	NME2	3.72478503
3	NEK1	3.62456894
4	PIK3CA	3.06878070
5	MAP4K2	2.89779220
6	WNK4	2.81817548
7	DYRK2	2.77645881
8	CDC7	2.63684517
9	EPHB2	2.57032899
10	NUAK1	2.54575004
11	GRK1	2.38172922
12	ERN1	2.35469721
13	ADRBK2	2.06872787
14	VRK2	1.89417635
15	BCKDK	1.89097500
16	MAP2K6	1.78137691
17	MAP3K12	1.77076679
18	BMPR1B	1.75444389
19	STK39	1.65134090
20	NME1	1.63903134
21	INSRR	1.58220983
22	MAP3K11	1.57196167
23	MAP2K7	1.53131784
24	CASK	1.36395045
25	PRKCG	1.34797535
26	TGFBR1	1.33567696
27	DAPK3	1.32639515
28	LRRK2	1.24340825
29	TAF1	1.23948576
30	PHKG1	1.17306642
31	PHKG2	1.17306642
32	FRK	1.16927518
33	WNK3	1.13535630
34	MAPKAPK3	1.12818103
35	RPS6KA6	1.08120609
36	PIM2	1.01273490
37	RPS6KB2	1.00508392
38	CAMK1	0.99981197
39	AURKB	0.91836726
40	NTRK3	0.90959582
41	RPS6KL1	0.87799597
42	RPS6KC1	0.87799597
43	PRKCH	0.85736561
44	NEK2	0.85173512
45	AURKA	0.84720692
46	MAP2K4	0.80167854
47	PASK	0.79622567
48	NTRK2	0.76387854
49	GRK5	0.75067760
50	MAPKAPK5	0.74182382
51	PRKD3	0.74174205
52	ABL2	0.71886981
53	TEC	0.71105896
54	MAP3K4	0.69613926
55	PINK1	0.67507473
56	DYRK1B	0.66621750
57	ZAK	0.65012979
58	CAMK1G	0.62469116
59	TGFBR2	0.61620258
60	TYRO3	0.61406453
61	STK16	0.61389437
62	ICK	0.61184938
63	PRKACA	0.60526145
64	EPHA4	0.58831722
65	ADRBK1	0.58291768
66	STK11	0.57312573
67	WNK1	0.56844099
68	CAMK2D	0.55932046
69	RPS6KA4	0.54212798
70	OXSR1	0.53745503
71	CAMK1D	0.51388641
72	PLK1	0.51200867
73	DYRK3	0.49968172
74	TESK2	0.47775595
75	RPS6KA5	0.47562859
76	CSNK2A2	0.46874466
77	CSNK2A1	0.46666729
78	VRK1	0.45843120
79	CHEK1	0.45189289
80	DAPK2	0.44357195
81	PRKACG	0.40663569
82	PRKCI	0.39889283
83	PRKCQ	0.39397610
84	CAMKK2	0.38268455
85	CSNK1E	0.37741004
86	MARK2	0.37122573
87	OBSCN	0.36595898
88	CSNK1A1	0.36447625
89	PRKCA	0.35496568
90	CSNK1G1	0.34469927
91	CSNK1G3	0.34326247
92	PLK2	0.34041557
93	ATR	0.33624234
94	TLK1	0.31022962
95	PRKCD	0.30238562
96	CAMK2A	0.29367537
97	RPS6KB1	0.29275524
98	PAK6	0.27335835
99	SGK1	0.26994882
100	AKT1	0.25637485

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.19830420
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.61593434
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.88781594
4	Parkinsons disease_Homo sapiens_hsa05012	2.82289566
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.31034726
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.28108570
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.19523902
8	Huntingtons disease_Homo sapiens_hsa05016	2.16290832
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.12585540
10	One carbon pool by folate_Homo sapiens_hsa00670	2.06565402
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.05842507
12	Alzheimers disease_Homo sapiens_hsa05010	2.04277155
13	Retinol metabolism_Homo sapiens_hsa00830	1.79141220
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.72159032
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.66458938
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.61632841
17	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.59869194
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.59454961
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55351759
20	RNA degradation_Homo sapiens_hsa03018	1.53285895
21	Caffeine metabolism_Homo sapiens_hsa00232	1.50231863
22	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.50069912
23	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.49655145
24	Protein export_Homo sapiens_hsa03060	1.49263506
25	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.46518421
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.44646523
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38399965
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35892226
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.35080565
30	Butanoate metabolism_Homo sapiens_hsa00650	1.30451455
31	RNA polymerase_Homo sapiens_hsa03020	1.27654826
32	Complement and coagulation cascades_Homo sapiens_hsa04610	1.24063680
33	Basal transcription factors_Homo sapiens_hsa03022	1.23747375
34	Homologous recombination_Homo sapiens_hsa03440	1.23609390
35	Fatty acid degradation_Homo sapiens_hsa00071	1.20969691
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19647002
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19023386
38	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.16516698
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14431739
40	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.14360436
41	Proteasome_Homo sapiens_hsa03050	1.13352180
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10379634
43	Peroxisome_Homo sapiens_hsa04146	1.07465177
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05760782
45	DNA replication_Homo sapiens_hsa03030	1.01580710
46	Asthma_Homo sapiens_hsa05310	1.00958276
47	Nitrogen metabolism_Homo sapiens_hsa00910	1.00677995
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98282462
49	Propanoate metabolism_Homo sapiens_hsa00640	0.96848884
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94431418
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92848038
52	Sulfur relay system_Homo sapiens_hsa04122	0.90303743
53	Base excision repair_Homo sapiens_hsa03410	0.89940485
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88966955
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88285374
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.86470137
57	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.85383120
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.83263105
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81431515
60	Metabolic pathways_Homo sapiens_hsa01100	0.77252876
61	Phototransduction_Homo sapiens_hsa04744	0.76572628
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74601133
63	Phenylalanine metabolism_Homo sapiens_hsa00360	0.74297431
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.71248750
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70351803
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.67460184
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65180745
68	Nicotine addiction_Homo sapiens_hsa05033	0.65167045
69	Mismatch repair_Homo sapiens_hsa03430	0.61704665
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.61531224
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.59797309
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58798245
73	Bile secretion_Homo sapiens_hsa04976	0.57178530
74	Purine metabolism_Homo sapiens_hsa00230	0.56440596
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.55544635
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52724013
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51804702
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50708590
79	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49168476
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47913913
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47901268
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44819063
83	Histidine metabolism_Homo sapiens_hsa00340	0.44292084
84	Morphine addiction_Homo sapiens_hsa05032	0.42777106
85	Olfactory transduction_Homo sapiens_hsa04740	0.42090296
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.39818937
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38225679
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.36214672
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31978884
90	Fatty acid elongation_Homo sapiens_hsa00062	0.30599367
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.27912735
92	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27660795
93	Mineral absorption_Homo sapiens_hsa04978	0.26846496
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26388594
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.25346319
96	Arginine biosynthesis_Homo sapiens_hsa00220	0.23637643
97	Serotonergic synapse_Homo sapiens_hsa04726	0.20819567
98	p53 signaling pathway_Homo sapiens_hsa04115	0.20218847
99	Carbon metabolism_Homo sapiens_hsa01200	0.19434807
100	Insulin secretion_Homo sapiens_hsa04911	0.19225327

RPL17P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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