ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	7.52499955
2	ribosomal small subunit assembly (GO:0000028)	6.76852238
3	viral transcription (GO:0019083)	6.55074176
4	translational termination (GO:0006415)	6.39073367
5	ribosomal small subunit biogenesis (GO:0042274)	5.92943228
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.40787162
7	cotranslational protein targeting to membrane (GO:0006613)	5.37572554
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.35602075
9	protein targeting to ER (GO:0045047)	5.30712504
10	translational elongation (GO:0006414)	5.10742211
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.06168532
12	protein localization to endoplasmic reticulum (GO:0070972)	5.03253613
13	cellular protein complex disassembly (GO:0043624)	4.83097574
14	viral life cycle (GO:0019058)	4.72480326
15	nonmotile primary cilium assembly (GO:0035058)	4.64493002
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.48045689
17	protein complex disassembly (GO:0043241)	4.13601197
18	somite development (GO:0061053)	4.12325491
19	ovulation cycle (GO:0042698)	4.12269660
20	cell proliferation in forebrain (GO:0021846)	4.10934125
21	macromolecular complex disassembly (GO:0032984)	3.98888692
22	tongue development (GO:0043586)	3.92201196
23	translational initiation (GO:0006413)	3.83190659
24	chaperone-mediated protein transport (GO:0072321)	3.83174387
25	regulation of cilium movement (GO:0003352)	3.71751069
26	ATP synthesis coupled proton transport (GO:0015986)	3.63475528
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.63475528
28	protein targeting to membrane (GO:0006612)	3.63196107
29	cellular ketone body metabolic process (GO:0046950)	3.63021914
30	behavioral response to nicotine (GO:0035095)	3.48600582
31	ribosomal large subunit biogenesis (GO:0042273)	3.42613391
32	epithelial cilium movement (GO:0003351)	3.39027922
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.33690907
34	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.32717781
35	substrate-independent telencephalic tangential migration (GO:0021826)	3.32717781
36	protein neddylation (GO:0045116)	3.32303831
37	ketone body metabolic process (GO:1902224)	3.19337002
38	Sertoli cell development (GO:0060009)	3.18923002
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.17811645
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16609455
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16609455
42	NADH dehydrogenase complex assembly (GO:0010257)	3.16609455
43	arginine catabolic process (GO:0006527)	3.12498930
44	dendritic spine morphogenesis (GO:0060997)	3.07618942
45	pattern specification involved in kidney development (GO:0061004)	3.06777764
46	pyrimidine nucleobase catabolic process (GO:0006208)	3.01743519
47	protein complex biogenesis (GO:0070271)	3.00874897
48	mRNA catabolic process (GO:0006402)	3.00069053
49	intraciliary transport (GO:0042073)	2.99993877
50	photoreceptor cell maintenance (GO:0045494)	2.99844295
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.95150369
52	translation (GO:0006412)	2.93721586
53	respiratory electron transport chain (GO:0022904)	2.90838828
54	electron transport chain (GO:0022900)	2.89835290
55	nephron epithelium morphogenesis (GO:0072088)	2.87077862
56	nephron tubule morphogenesis (GO:0072078)	2.87077862
57	cilium morphogenesis (GO:0060271)	2.85204957
58	body morphogenesis (GO:0010171)	2.81971529
59	platelet dense granule organization (GO:0060155)	2.79100594
60	protein polyglutamylation (GO:0018095)	2.78472696
61	response to redox state (GO:0051775)	2.76729884
62	myoblast migration (GO:0051451)	2.73421180
63	head development (GO:0060322)	2.72311663
64	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70137645
65	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70137645
66	aldehyde catabolic process (GO:0046185)	2.65562124
67	water-soluble vitamin biosynthetic process (GO:0042364)	2.65236553
68	RNA catabolic process (GO:0006401)	2.60170690
69	segment specification (GO:0007379)	2.59365278
70	regulation of microtubule-based movement (GO:0060632)	2.59101357
71	positive regulation of neurological system process (GO:0031646)	2.57640824
72	ubiquinone biosynthetic process (GO:0006744)	2.57253773
73	cell wall macromolecule catabolic process (GO:0016998)	2.57134743
74	negative regulation of systemic arterial blood pressure (GO:0003085)	2.56246357
75	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.53891331
76	establishment of protein localization to membrane (GO:0090150)	2.53582421
77	cilium movement (GO:0003341)	2.52589061
78	left/right axis specification (GO:0070986)	2.52288161
79	mitochondrial respiratory chain complex assembly (GO:0033108)	2.52134821
80	cardiac left ventricle morphogenesis (GO:0003214)	2.47912716
81	amine catabolic process (GO:0009310)	2.47811929
82	cellular biogenic amine catabolic process (GO:0042402)	2.47811929
83	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.46249384
84	kidney morphogenesis (GO:0060993)	2.46216507
85	hydrogen ion transmembrane transport (GO:1902600)	2.44778538
86	axonemal dynein complex assembly (GO:0070286)	2.44675533
87	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.44196871
88	protein targeting (GO:0006605)	2.42912380
89	L-serine metabolic process (GO:0006563)	2.42902798
90	response to pheromone (GO:0019236)	2.42500325
91	nucleobase catabolic process (GO:0046113)	2.40190269
92	auditory receptor cell differentiation (GO:0042491)	2.39661196
93	neuron fate determination (GO:0048664)	2.38844453
94	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.38175470
95	otic vesicle formation (GO:0030916)	2.37035649
96	organelle disassembly (GO:1903008)	2.36017156
97	postsynaptic membrane organization (GO:0001941)	2.35628875
98	axonal fasciculation (GO:0007413)	2.32519307
99	negative regulation of response to food (GO:0032096)	2.32441262
100	negative regulation of appetite (GO:0032099)	2.32441262

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.78809459
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.43683463
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.15363347
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.96658485
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.69099539
6	VDR_22108803_ChIP-Seq_LS180_Human	2.28141385
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.19474797
8	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.98315634
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97671395
10	GBX2_23144817_ChIP-Seq_PC3_Human	1.94438599
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.89281629
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.88931480
13	FUS_26573619_Chip-Seq_HEK293_Human	1.80363033
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74902081
15	EWS_26573619_Chip-Seq_HEK293_Human	1.72146764
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69955749
17	P300_19829295_ChIP-Seq_ESCs_Human	1.68156265
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65031113
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47825375
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47323964
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.46832362
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44718515
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.44166616
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.43591858
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38911578
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38825528
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38351082
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37746900
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.37440354
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.36451362
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35624136
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34316672
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.34003861
34	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33447105
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33407677
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32533282
37	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31505774
38	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.26913774
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.26893686
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26009543
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25482760
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23822653
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.23289491
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23132298
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21568360
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21322852
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20487980
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.20130630
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18895773
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17862479
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17859865
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17763961
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17392305
54	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16355431
55	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15901315
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15026920
57	STAT3_23295773_ChIP-Seq_U87_Human	1.14967402
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.14347674
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14347674
60	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13404069
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12899339
62	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.12345060
63	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.11154816
64	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10421998
65	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.10173362
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09658762
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09658762
68	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08193766
69	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08050954
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07427466
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06327649
72	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.05453040
73	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.05453040
74	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.05386284
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.03017990
76	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.03013902
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02912423
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02751435
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02387487
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02146072
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.01758422
82	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01449410
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01449410
84	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.99656838
85	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99652410
86	TCF4_23295773_ChIP-Seq_U87_Human	0.99146445
87	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.98794513
88	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98547372
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97672413
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97083709
91	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96595141
92	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96432158
93	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.95806652
94	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.95401568
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94939794
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94939794
97	AR_25329375_ChIP-Seq_VCAP_Human	0.94723255
98	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94674343
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94118910
100	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.94047557

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.47385967
2	MP0003122_maternal_imprinting	3.73950796
3	MP0006292_abnormal_olfactory_placode	3.60043406
4	MP0003787_abnormal_imprinting	3.06868186
5	MP0008877_abnormal_DNA_methylation	2.81881641
6	MP0004142_abnormal_muscle_tone	2.60156045
7	MP0003121_genomic_imprinting	2.59328842
8	MP0001986_abnormal_taste_sensitivity	2.37720129
9	MP0003123_paternal_imprinting	2.18644146
10	MP0001984_abnormal_olfaction	2.02837095
11	MP0001485_abnormal_pinna_reflex	2.00512714
12	MP0008789_abnormal_olfactory_epithelium	1.93018782
13	MP0010030_abnormal_orbit_morphology	1.83394977
14	MP0001529_abnormal_vocalization	1.76621974
15	MP0006072_abnormal_retinal_apoptosis	1.72542633
16	MP0005551_abnormal_eye_electrophysiolog	1.69691764
17	MP0001968_abnormal_touch/_nociception	1.68397645
18	MP0003646_muscle_fatigue	1.68199525
19	MP0000778_abnormal_nervous_system	1.67980059
20	MP0002938_white_spotting	1.66461036
21	MP0000613_abnormal_salivary_gland	1.57265126
22	MP0000049_abnormal_middle_ear	1.54519676
23	MP0001293_anophthalmia	1.52416265
24	MP0002282_abnormal_trachea_morphology	1.51631846
25	MP0003315_abnormal_perineum_morphology	1.51531654
26	MP0003880_abnormal_central_pattern	1.40379411
27	MP0005394_taste/olfaction_phenotype	1.39099661
28	MP0005499_abnormal_olfactory_system	1.39099661
29	MP0005084_abnormal_gallbladder_morpholo	1.34154366
30	MP0003878_abnormal_ear_physiology	1.33016036
31	MP0005377_hearing/vestibular/ear_phenot	1.33016036
32	MP0000427_abnormal_hair_cycle	1.32120318
33	MP0002653_abnormal_ependyma_morphology	1.29688821
34	MP0002736_abnormal_nociception_after	1.28852037
35	MP0005195_abnormal_posterior_eye	1.28749341
36	MP0005423_abnormal_somatic_nervous	1.25018814
37	MP0006276_abnormal_autonomic_nervous	1.23730220
38	MP0009053_abnormal_anal_canal	1.23030934
39	MP0000383_abnormal_hair_follicle	1.22318701
40	MP0004885_abnormal_endolymph	1.21806678
41	MP0003136_yellow_coat_color	1.20334535
42	MP0004133_heterotaxia	1.18658673
43	MP0002272_abnormal_nervous_system	1.16301920
44	MP0002557_abnormal_social/conspecific_i	1.15724173
45	MP0000631_abnormal_neuroendocrine_gland	1.15390849
46	MP0001486_abnormal_startle_reflex	1.14844502
47	MP0002734_abnormal_mechanical_nocicepti	1.09438534
48	MP0003937_abnormal_limbs/digits/tail_de	1.09416409
49	MP0001963_abnormal_hearing_physiology	1.06803641
50	MP0000516_abnormal_urinary_system	1.04916325
51	MP0005367_renal/urinary_system_phenotyp	1.04916325
52	MP0003942_abnormal_urinary_system	1.04409180
53	MP0009046_muscle_twitch	1.04240041
54	MP0004742_abnormal_vestibular_system	1.03714218
55	MP0003879_abnormal_hair_cell	1.03240354
56	MP0005646_abnormal_pituitary_gland	1.03031047
57	MP0002752_abnormal_somatic_nervous	1.02454977
58	MP0005253_abnormal_eye_physiology	1.01480655
59	MP0001970_abnormal_pain_threshold	0.99776397
60	MP0002063_abnormal_learning/memory/cond	0.99728765
61	MP0009745_abnormal_behavioral_response	0.99541507
62	MP0002163_abnormal_gland_morphology	0.98904426
63	MP0001299_abnormal_eye_distance/	0.98412902
64	MP0002233_abnormal_nose_morphology	0.96993003
65	MP0002234_abnormal_pharynx_morphology	0.96780678
66	MP0003186_abnormal_redox_activity	0.96312002
67	MP0002184_abnormal_innervation	0.95110581
68	MP0000026_abnormal_inner_ear	0.93972081
69	MP0001286_abnormal_eye_development	0.91628218
70	MP0002095_abnormal_skin_pigmentation	0.90911728
71	MP0002572_abnormal_emotion/affect_behav	0.90866068
72	MP0008775_abnormal_heart_ventricle	0.90085835
73	MP0002733_abnormal_thermal_nociception	0.89594391
74	MP0002735_abnormal_chemical_nociception	0.88541589
75	MP0001905_abnormal_dopamine_level	0.87311735
76	MP0002102_abnormal_ear_morphology	0.85223670
77	MP0005408_hypopigmentation	0.85160363
78	MP0003195_calcinosis	0.84577190
79	MP0005332_abnormal_amino_acid	0.84170973
80	MP0003755_abnormal_palate_morphology	0.83234621
81	MP0002638_abnormal_pupillary_reflex	0.82534524
82	MP0002254_reproductive_system_inflammat	0.81610533
83	MP0000955_abnormal_spinal_cord	0.81325501
84	MP0003119_abnormal_digestive_system	0.81086236
85	MP0003938_abnormal_ear_development	0.80913164
86	MP0000647_abnormal_sebaceous_gland	0.80262271
87	MP0000230_abnormal_systemic_arterial	0.80063864
88	MP0009384_cardiac_valve_regurgitation	0.79710967
89	MP0004145_abnormal_muscle_electrophysio	0.78716519
90	MP0002249_abnormal_larynx_morphology	0.78659847
91	MP0001440_abnormal_grooming_behavior	0.78010623
92	MP0002067_abnormal_sensory_capabilities	0.77444255
93	MP0002138_abnormal_hepatobiliary_system	0.76826043
94	MP0003635_abnormal_synaptic_transmissio	0.76651094
95	MP0001324_abnormal_eye_pigmentation	0.76550223
96	MP0005389_reproductive_system_phenotype	0.76185340
97	MP0008872_abnormal_physiological_respon	0.74729420
98	MP0009250_abnormal_appendicular_skeleto	0.73338419
99	MP0001270_distended_abdomen	0.71528149
100	MP0000537_abnormal_urethra_morphology	0.70814953

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.52922540
2	Abnormality of midbrain morphology (HP:0002418)	4.54842360
3	Molar tooth sign on MRI (HP:0002419)	4.54842360
4	Pancreatic fibrosis (HP:0100732)	3.94802279
5	Stenosis of the external auditory canal (HP:0000402)	3.91831802
6	Septo-optic dysplasia (HP:0100842)	3.58579188
7	Abnormality of cells of the erythroid lineage (HP:0012130)	3.57448976
8	Acute necrotizing encephalopathy (HP:0006965)	3.44022120
9	Nephronophthisis (HP:0000090)	3.41596569
10	Medial flaring of the eyebrow (HP:0010747)	3.40956856
11	Pancreatic cysts (HP:0001737)	3.40632804
12	Macrocytic anemia (HP:0001972)	3.30428508
13	Acute encephalopathy (HP:0006846)	3.27375388
14	Gait imbalance (HP:0002141)	3.16219359
15	Congenital primary aphakia (HP:0007707)	3.00274763
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.93503722
17	Abnormality of the renal medulla (HP:0100957)	2.87912543
18	Cystic liver disease (HP:0006706)	2.80294468
19	Nephrogenic diabetes insipidus (HP:0009806)	2.80016736
20	Papilledema (HP:0001085)	2.78794873
21	True hermaphroditism (HP:0010459)	2.78786813
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.74634422
23	Progressive macrocephaly (HP:0004481)	2.74457508
24	Mitochondrial inheritance (HP:0001427)	2.72672422
25	Increased CSF lactate (HP:0002490)	2.65314268
26	Absent thumb (HP:0009777)	2.62532221
27	Tubular atrophy (HP:0000092)	2.58677674
28	Vaginal atresia (HP:0000148)	2.54892947
29	Pendular nystagmus (HP:0012043)	2.49933928
30	Abnormal hemoglobin (HP:0011902)	2.48978631
31	Genital tract atresia (HP:0001827)	2.48784734
32	Polyphagia (HP:0002591)	2.46912737
33	Bile duct proliferation (HP:0001408)	2.46710494
34	Abnormal biliary tract physiology (HP:0012439)	2.46710494
35	Chronic hepatic failure (HP:0100626)	2.46396308
36	Supernumerary spleens (HP:0009799)	2.40912254
37	Increased hepatocellular lipid droplets (HP:0006565)	2.40211221
38	Poor coordination (HP:0002370)	2.38921386
39	Tubulointerstitial nephritis (HP:0001970)	2.37865891
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.30569418
41	Growth hormone deficiency (HP:0000824)	2.28987327
42	Lipid accumulation in hepatocytes (HP:0006561)	2.26830581
43	Asplenia (HP:0001746)	2.26580396
44	Pallor (HP:0000980)	2.26089972
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.16227054
46	Hepatocellular necrosis (HP:0001404)	2.15451670
47	Optic nerve hypoplasia (HP:0000609)	2.15114642
48	Postaxial foot polydactyly (HP:0001830)	2.14950057
49	Intestinal atresia (HP:0011100)	2.14790108
50	Bifid tongue (HP:0010297)	2.13383941
51	Cerebral edema (HP:0002181)	2.10855723
52	Maternal diabetes (HP:0009800)	2.09061998
53	Adrenal hypoplasia (HP:0000835)	2.07806611
54	Abnormal drinking behavior (HP:0030082)	2.07238048
55	Polydipsia (HP:0001959)	2.07238048
56	Anencephaly (HP:0002323)	2.06240958
57	Pancreatic islet-cell hyperplasia (HP:0004510)	2.05800283
58	Abnormal number of erythroid precursors (HP:0012131)	2.04388931
59	Ectopic kidney (HP:0000086)	2.04028649
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03859011
61	Absent/shortened dynein arms (HP:0200106)	2.03754652
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03754652
63	Sclerocornea (HP:0000647)	2.01077638
64	Narrow forehead (HP:0000341)	2.00070118
65	Keratoconus (HP:0000563)	1.98872440
66	Increased corneal curvature (HP:0100692)	1.98872440
67	Anophthalmia (HP:0000528)	1.97976748
68	Agitation (HP:0000713)	1.96624106
69	Cerebellar dysplasia (HP:0007033)	1.96356772
70	Renal Fanconi syndrome (HP:0001994)	1.95462420
71	Hip dysplasia (HP:0001385)	1.95040209
72	Absent septum pellucidum (HP:0001331)	1.94850390
73	Depressed nasal ridge (HP:0000457)	1.94760304
74	Type II lissencephaly (HP:0007260)	1.94739404
75	Optic disc pallor (HP:0000543)	1.94539577
76	Focal seizures (HP:0007359)	1.92699080
77	Rib fusion (HP:0000902)	1.92432565
78	Hyperventilation (HP:0002883)	1.90639868
79	Hypoplasia of the radius (HP:0002984)	1.90466557
80	Hyperglycinemia (HP:0002154)	1.90172167
81	Abolished electroretinogram (ERG) (HP:0000550)	1.89170243
82	Abnormality of the renal cortex (HP:0011035)	1.87391346
83	Chorioretinal atrophy (HP:0000533)	1.86908902
84	Postaxial hand polydactyly (HP:0001162)	1.85070098
85	Tubulointerstitial abnormality (HP:0001969)	1.84064828
86	Colon cancer (HP:0003003)	1.83102701
87	Congenital stationary night blindness (HP:0007642)	1.82033810
88	Abnormality of DNA repair (HP:0003254)	1.81550613
89	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.81228674
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.81109679
91	Abnormality of the labia minora (HP:0012880)	1.80356413
92	Hypoplasia of the ulna (HP:0003022)	1.77053732
93	Congenital hepatic fibrosis (HP:0002612)	1.76662499
94	Hepatic necrosis (HP:0002605)	1.76605609
95	Hyperglycemia (HP:0003074)	1.76521581
96	Partial duplication of thumb phalanx (HP:0009944)	1.76326385
97	Concave nail (HP:0001598)	1.75011607
98	Abnormality of the metopic suture (HP:0005556)	1.74502330
99	Status epilepticus (HP:0002133)	1.73914963
100	Pachygyria (HP:0001302)	1.72683514

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	2.86164492
2	EPHB2	2.75370946
3	GRK1	2.62316185
4	WNK4	2.61506334
5	PDK2	2.53807058
6	LIMK1	2.51852684
7	MAP4K2	2.48079516
8	NUAK1	2.37552928
9	PIK3CA	2.31356217
10	WNK3	2.28980892
11	ADRBK2	2.22655433
12	DYRK2	2.18518450
13	PINK1	2.02672375
14	LRRK2	1.80092663
15	TNIK	1.79669660
16	BCKDK	1.68524294
17	PAK3	1.67570782
18	TIE1	1.65469493
19	PLK2	1.64558286
20	MAP3K12	1.56800833
21	MAPK13	1.54099660
22	CASK	1.49666129
23	STK39	1.47104817
24	NTRK2	1.42146357
25	ZAK	1.41508304
26	CDC7	1.39613689
27	TRIM28	1.37206025
28	PRKCG	1.28957370
29	MKNK2	1.23798339
30	AKT3	1.19802417
31	CAMK1	1.17574694
32	ERBB4	1.10558329
33	CDK19	1.09484494
34	PKN1	1.07335143
35	BMPR1B	1.04293726
36	MARK1	1.01043588
37	EPHA4	0.99627209
38	MAP3K4	0.97802252
39	ADRBK1	0.97260968
40	PRKCI	0.95989519
41	SGK223	0.95968843
42	SGK494	0.95968843
43	PHKG2	0.92970682
44	PHKG1	0.92970682
45	PRKCE	0.89588237
46	ROCK1	0.87929488
47	PRKCZ	0.87066777
48	MINK1	0.85990600
49	DMPK	0.85570766
50	OBSCN	0.81097013
51	STK11	0.77869900
52	GRK7	0.76403183
53	MAP3K11	0.75953920
54	PRKCH	0.75378457
55	CSNK1G2	0.75156258
56	CAMK2D	0.74910981
57	PRKCQ	0.72611465
58	PRKACA	0.71669245
59	MARK2	0.71285871
60	PLK3	0.70726930
61	OXSR1	0.69787360
62	INSRR	0.68401633
63	DAPK3	0.67546593
64	CSNK1E	0.66026654
65	CAMK2A	0.65814088
66	CHEK2	0.65433796
67	PRKD3	0.65317991
68	CAMK1G	0.63845978
69	NEK1	0.62586763
70	BCR	0.62089524
71	CSNK2A2	0.61815302
72	CAMKK2	0.61751987
73	CAMK1D	0.60328229
74	BRAF	0.59169788
75	PAK6	0.58728225
76	CSNK1G1	0.57478339
77	ERBB2	0.57380186
78	SRPK1	0.57378764
79	MYLK	0.56531675
80	MKNK1	0.54163624
81	PNCK	0.53340135
82	WNK1	0.53089085
83	STK16	0.49970228
84	ILK	0.48908910
85	PRKCA	0.46154166
86	PRKG1	0.45786783
87	AURKB	0.45063968
88	PLK1	0.43852916
89	SGK3	0.43231647
90	PASK	0.43188774
91	PRKAA1	0.41244897
92	ROCK2	0.41151644
93	CDC42BPA	0.40917264
94	CSNK1G3	0.40546392
95	PRKDC	0.40349024
96	CHEK1	0.39515677
97	CSNK1D	0.39297648
98	SGK1	0.37677571
99	MAP2K7	0.37611435
100	PRKCD	0.37027300

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.80302543
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.46459303
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.34857257
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.80527751
5	Parkinsons disease_Homo sapiens_hsa05012	2.75516057
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.27100564
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.18303758
8	Huntingtons disease_Homo sapiens_hsa05016	2.10191216
9	RNA polymerase_Homo sapiens_hsa03020	2.06268338
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.03897890
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01796650
12	Fat digestion and absorption_Homo sapiens_hsa04975	1.96912896
13	Butanoate metabolism_Homo sapiens_hsa00650	1.94143458
14	Propanoate metabolism_Homo sapiens_hsa00640	1.89208691
15	Alzheimers disease_Homo sapiens_hsa05010	1.87473223
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.82152027
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79572269
18	Protein export_Homo sapiens_hsa03060	1.76430918
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.67074321
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.65762605
21	Phototransduction_Homo sapiens_hsa04744	1.55537048
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50208632
23	Peroxisome_Homo sapiens_hsa04146	1.47713740
24	Basal transcription factors_Homo sapiens_hsa03022	1.43857372
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.41972903
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.37047747
27	RNA degradation_Homo sapiens_hsa03018	1.22258255
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20547056
29	Caffeine metabolism_Homo sapiens_hsa00232	1.18519993
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.16496247
31	Fatty acid degradation_Homo sapiens_hsa00071	1.14225631
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13531732
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13210456
34	Nicotine addiction_Homo sapiens_hsa05033	1.12916465
35	Homologous recombination_Homo sapiens_hsa03440	1.12028870
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.11236089
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09922072
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06295330
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05959364
40	Insulin secretion_Homo sapiens_hsa04911	1.01969191
41	Sulfur relay system_Homo sapiens_hsa04122	0.98394671
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.93482904
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91941677
44	Basal cell carcinoma_Homo sapiens_hsa05217	0.91715228
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89395185
46	One carbon pool by folate_Homo sapiens_hsa00670	0.87042931
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.86623546
48	Taste transduction_Homo sapiens_hsa04742	0.85949603
49	Proteasome_Homo sapiens_hsa03050	0.85652081
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84057351
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83968571
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82486716
53	Morphine addiction_Homo sapiens_hsa05032	0.82132247
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82025642
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81938662
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79865563
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.79674166
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77258288
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72093271
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71633392
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.71146469
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70851672
63	Lysine degradation_Homo sapiens_hsa00310	0.69340102
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68949319
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.68271381
66	Metabolic pathways_Homo sapiens_hsa01100	0.68042946
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.66716291
68	Glutathione metabolism_Homo sapiens_hsa00480	0.66674054
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.63723474
70	Olfactory transduction_Homo sapiens_hsa04740	0.62501864
71	Retinol metabolism_Homo sapiens_hsa00830	0.62037905
72	Folate biosynthesis_Homo sapiens_hsa00790	0.57449448
73	Circadian entrainment_Homo sapiens_hsa04713	0.56722385
74	Pancreatic secretion_Homo sapiens_hsa04972	0.56711565
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56357600
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.55791412
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52403908
78	GABAergic synapse_Homo sapiens_hsa04727	0.50887607
79	Axon guidance_Homo sapiens_hsa04360	0.50489551
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50064605
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49883765
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49495955
83	Purine metabolism_Homo sapiens_hsa00230	0.49296949
84	Serotonergic synapse_Homo sapiens_hsa04726	0.47459971
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.47228121
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45554415
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41232470
88	Mismatch repair_Homo sapiens_hsa03430	0.41153255
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.39904806
90	Tight junction_Homo sapiens_hsa04530	0.39898168
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39404337
92	Fatty acid elongation_Homo sapiens_hsa00062	0.38332976
93	Salivary secretion_Homo sapiens_hsa04970	0.36174950
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.35754675
95	ABC transporters_Homo sapiens_hsa02010	0.34779467
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31624338
97	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30597614
98	Histidine metabolism_Homo sapiens_hsa00340	0.30552480
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29771162
100	Bile secretion_Homo sapiens_hsa04976	0.29559685

RPL17P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »