RPL17P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)8.14885238
2viral transcription (GO:0019083)7.66782130
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.60828848
4ATP synthesis coupled proton transport (GO:0015986)7.60828848
5translational termination (GO:0006415)7.36093841
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.21188894
7ribosomal small subunit assembly (GO:0000028)7.12900359
8ribosomal small subunit biogenesis (GO:0042274)6.51206383
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.43471591
10cotranslational protein targeting to membrane (GO:0006613)6.32058365
11protein targeting to ER (GO:0045047)6.30978585
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.04625959
13establishment of protein localization to endoplasmic reticulum (GO:0072599)6.02896342
14translational elongation (GO:0006414)6.02676671
15protein localization to endoplasmic reticulum (GO:0070972)5.91271220
16respiratory electron transport chain (GO:0022904)5.57198120
17cellular protein complex disassembly (GO:0043624)5.53036276
18electron transport chain (GO:0022900)5.51020421
19viral life cycle (GO:0019058)5.45885141
20chaperone-mediated protein transport (GO:0072321)5.42901608
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.31200898
22establishment of protein localization to mitochondrial membrane (GO:0090151)5.19643814
23protein neddylation (GO:0045116)5.17753690
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.90920233
25NADH dehydrogenase complex assembly (GO:0010257)4.90920233
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.90920233
27protein complex biogenesis (GO:0070271)4.83465596
28ribosomal large subunit biogenesis (GO:0042273)4.70549736
29translational initiation (GO:0006413)4.66719073
30protein complex disassembly (GO:0043241)4.65312410
31ATP biosynthetic process (GO:0006754)4.57240658
32macromolecular complex disassembly (GO:0032984)4.47389024
33mitochondrial respiratory chain complex assembly (GO:0033108)4.24246010
34translation (GO:0006412)4.22129265
35protein targeting to membrane (GO:0006612)4.16796815
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.10146541
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.08650972
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.06154786
39purine nucleoside triphosphate biosynthetic process (GO:0009145)4.02916284
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.91226656
41cell wall macromolecule metabolic process (GO:0044036)3.90482098
42behavioral response to nicotine (GO:0035095)3.87333032
43aldehyde catabolic process (GO:0046185)3.82156498
44mRNA catabolic process (GO:0006402)3.71431223
45hydrogen ion transmembrane transport (GO:1902600)3.67898573
46positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.62849067
47regulation of hypersensitivity (GO:0002883)3.57197886
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56525537
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56525537
50ribonucleoside triphosphate biosynthetic process (GO:0009201)3.49568145
51RNA catabolic process (GO:0006401)3.46627220
52cellular component biogenesis (GO:0044085)3.36460935
53platelet dense granule organization (GO:0060155)3.31168651
54proton transport (GO:0015992)3.27290798
55rRNA catabolic process (GO:0016075)3.24590136
56protein-cofactor linkage (GO:0018065)3.23863707
57preassembly of GPI anchor in ER membrane (GO:0016254)3.21641556
58hydrogen transport (GO:0006818)3.20446693
59regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.18243622
60negative regulation of heart rate (GO:0010459)3.11464843
61regulation of cellular respiration (GO:0043457)3.07648140
62response to pheromone (GO:0019236)3.07142745
63nonmotile primary cilium assembly (GO:0035058)3.06642998
64ribonucleoprotein complex biogenesis (GO:0022613)3.03779348
65nucleoside triphosphate biosynthetic process (GO:0009142)2.99693638
66substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.97064402
67substrate-independent telencephalic tangential migration (GO:0021826)2.97064402
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92525446
69respiratory chain complex IV assembly (GO:0008535)2.87100013
70kynurenine metabolic process (GO:0070189)2.84758367
71establishment of protein localization to membrane (GO:0090150)2.83026325
72rRNA processing (GO:0006364)2.81412659
73cell proliferation in forebrain (GO:0021846)2.78386590
74rRNA metabolic process (GO:0016072)2.76943671
75negative regulation of mast cell activation (GO:0033004)2.70009371
76protein targeting (GO:0006605)2.69400419
77oxidative phosphorylation (GO:0006119)2.69014687
78cytochrome complex assembly (GO:0017004)2.68625638
79DNA deamination (GO:0045006)2.68341880
80gonadal mesoderm development (GO:0007506)2.66149075
81regulation of action potential (GO:0098900)2.65455144
82intracellular protein transmembrane import (GO:0044743)2.64782400
83GTP biosynthetic process (GO:0006183)2.61015170
84RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.60365971
85spliceosomal complex assembly (GO:0000245)2.59049690
86purine nucleoside monophosphate biosynthetic process (GO:0009127)2.58135899
87purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.58135899
88pseudouridine synthesis (GO:0001522)2.57528817
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55012295
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.54514604
91termination of RNA polymerase III transcription (GO:0006386)2.54514604
92kidney morphogenesis (GO:0060993)2.53494148
93tongue development (GO:0043586)2.52315376
94base-excision repair, AP site formation (GO:0006285)2.52132341
95RNA phosphodiester bond hydrolysis (GO:0090501)2.51829356
96peptidyl-histidine modification (GO:0018202)2.51527983
97positive regulation of respiratory burst (GO:0060267)2.49859545
98neuron fate determination (GO:0048664)2.49635168
99DNA replication checkpoint (GO:0000076)2.48331083
100pyrimidine nucleotide catabolic process (GO:0006244)2.48258636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.52576156
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94686966
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.67264312
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21470704
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17038808
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.11868509
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81126514
8ZNF274_21170338_ChIP-Seq_K562_Hela2.65601056
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58792596
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.37672400
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34701380
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.34425680
13VDR_23849224_ChIP-Seq_CD4+_Human1.90483319
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86830755
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80955522
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80924326
17ELK1_19687146_ChIP-ChIP_HELA_Human1.78941626
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.77853489
19VDR_22108803_ChIP-Seq_LS180_Human1.72076566
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71214160
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71065290
22FOXP3_21729870_ChIP-Seq_TREG_Human1.70171446
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66009509
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64919367
25TTF2_22483619_ChIP-Seq_HELA_Human1.61256717
26TP53_22573176_ChIP-Seq_HFKS_Human1.59886297
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59761893
28MYC_18940864_ChIP-ChIP_HL60_Human1.57068589
29TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54246018
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51457009
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47818705
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.46950980
33GATA3_21878914_ChIP-Seq_MCF-7_Human1.45494044
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.44023199
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43514645
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40549534
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40027538
38EWS_26573619_Chip-Seq_HEK293_Human1.39827921
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34832090
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.34393891
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.34373653
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34373653
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33662674
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31953360
45AR_20517297_ChIP-Seq_VCAP_Human1.31681698
46FOXH1_21741376_ChIP-Seq_EPCs_Human1.31642038
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29656502
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29581302
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.29082536
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28147871
51TAF15_26573619_Chip-Seq_HEK293_Human1.27689996
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23503968
53TAF2_19829295_ChIP-Seq_ESCs_Human1.23364755
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22371160
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21566706
56NANOG_20526341_ChIP-Seq_ESCs_Human1.20308788
57IGF1R_20145208_ChIP-Seq_DFB_Human1.18388159
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18004672
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14887776
60ERG_20517297_ChIP-Seq_VCAP_Human1.12821162
61ER_23166858_ChIP-Seq_MCF-7_Human1.12794232
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12628298
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12453607
64FUS_26573619_Chip-Seq_HEK293_Human1.12207742
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09438730
66IRF1_19129219_ChIP-ChIP_H3396_Human1.09185679
67GABP_19822575_ChIP-Seq_HepG2_Human1.09021604
68NCOR_22424771_ChIP-Seq_293T_Human1.08702392
69XRN2_22483619_ChIP-Seq_HELA_Human1.07106476
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04460379
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02554501
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00904463
73GATA6_21074721_ChIP-Seq_CACO-2_Human1.00833099
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99795840
75EZH2_27294783_Chip-Seq_ESCs_Mouse0.99543627
76EED_16625203_ChIP-ChIP_MESCs_Mouse0.99148059
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99075624
78PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98529706
79MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97674473
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97104436
81E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96744939
82TCF4_22108803_ChIP-Seq_LS180_Human0.96732716
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96367841
84RNF2_27304074_Chip-Seq_NSC_Mouse0.96138677
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.95531965
86MYC_19829295_ChIP-Seq_ESCs_Human0.94803361
87P300_19829295_ChIP-Seq_ESCs_Human0.93973823
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93167552
89GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92533501
90RBPJ_21746931_ChIP-Seq_IB4_Human0.92507152
91ERA_21632823_ChIP-Seq_H3396_Human0.92187856
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90523877
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89644748
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.89523391
95HOXB7_26014856_ChIP-Seq_BT474_Human0.88775540
96REST_21632747_ChIP-Seq_MESCs_Mouse0.87563130
97NANOG_19829295_ChIP-Seq_ESCs_Human0.87302161
98SOX2_19829295_ChIP-Seq_ESCs_Human0.87302161
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85845210
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85753559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.91859325
2MP0006292_abnormal_olfactory_placode4.45360065
3MP0005646_abnormal_pituitary_gland2.63652564
4MP0008877_abnormal_DNA_methylation2.63538695
5MP0003787_abnormal_imprinting2.59280864
6MP0002102_abnormal_ear_morphology2.37725011
7MP0002837_dystrophic_cardiac_calcinosis2.34829491
8MP0003122_maternal_imprinting2.28310841
9MP0002163_abnormal_gland_morphology2.23901858
10MP0008872_abnormal_physiological_respon2.22537284
11MP0002234_abnormal_pharynx_morphology2.22507814
12MP0004147_increased_porphyrin_level2.19074536
13MP0003646_muscle_fatigue2.19047548
14MP0004142_abnormal_muscle_tone2.16489456
15MP0004145_abnormal_muscle_electrophysio2.02101852
16MP0008789_abnormal_olfactory_epithelium1.91494312
17MP0003121_genomic_imprinting1.80751169
18MP0005671_abnormal_response_to1.73790820
19MP0005551_abnormal_eye_electrophysiolog1.73132614
20MP0004885_abnormal_endolymph1.65181619
21MP0002736_abnormal_nociception_after1.64556802
22MP0002653_abnormal_ependyma_morphology1.58507993
23MP0002876_abnormal_thyroid_physiology1.53790416
24MP0006036_abnormal_mitochondrial_physio1.48961636
25MP0001440_abnormal_grooming_behavior1.43034919
26MP0003878_abnormal_ear_physiology1.40512938
27MP0005377_hearing/vestibular/ear_phenot1.40512938
28MP0001486_abnormal_startle_reflex1.39805486
29MP0001968_abnormal_touch/_nociception1.38250250
30MP0000049_abnormal_middle_ear1.36743246
31MP0008875_abnormal_xenobiotic_pharmacok1.36206505
32MP0005367_renal/urinary_system_phenotyp1.36003138
33MP0000516_abnormal_urinary_system1.36003138
34MP0001835_abnormal_antigen_presentation1.35140877
35MP0003186_abnormal_redox_activity1.35042177
36MP0005394_taste/olfaction_phenotype1.33760368
37MP0005499_abnormal_olfactory_system1.33760368
38MP0009046_muscle_twitch1.33149496
39MP0001485_abnormal_pinna_reflex1.32176783
40MP0010030_abnormal_orbit_morphology1.31285667
41MP0006072_abnormal_retinal_apoptosis1.30897110
42MP0001293_anophthalmia1.29707306
43MP0005379_endocrine/exocrine_gland_phen1.24770605
44MP0003195_calcinosis1.24352660
45MP0001919_abnormal_reproductive_system1.23070497
46MP0001986_abnormal_taste_sensitivity1.22953620
47MP0005408_hypopigmentation1.22447918
48MP0005389_reproductive_system_phenotype1.21697252
49MP0002160_abnormal_reproductive_system1.20838562
50MP0002095_abnormal_skin_pigmentation1.16557128
51MP0009764_decreased_sensitivity_to1.12800611
52MP0002272_abnormal_nervous_system1.09036063
53MP0009745_abnormal_behavioral_response1.08779639
54MP0001970_abnormal_pain_threshold1.08580641
55MP0000631_abnormal_neuroendocrine_gland1.05519114
56MP0005195_abnormal_posterior_eye1.02854400
57MP0001348_abnormal_lacrimal_gland1.02792913
58MP0002938_white_spotting1.02383882
59MP0003011_delayed_dark_adaptation1.01196135
60MP0000372_irregular_coat_pigmentation1.00924693
61MP0001984_abnormal_olfaction0.99401058
62MP0000026_abnormal_inner_ear0.97470625
63MP0001905_abnormal_dopamine_level0.97015246
64MP0005075_abnormal_melanosome_morpholog0.96521767
65MP0006035_abnormal_mitochondrial_morpho0.96346452
66MP0005423_abnormal_somatic_nervous0.96277710
67MP0001963_abnormal_hearing_physiology0.95840201
68MP0006276_abnormal_autonomic_nervous0.94690722
69MP0008995_early_reproductive_senescence0.93351941
70MP0002184_abnormal_innervation0.93305585
71MP0003283_abnormal_digestive_organ0.91850829
72MP0002064_seizures0.91686678
73MP0004742_abnormal_vestibular_system0.91395307
74MP0002277_abnormal_respiratory_mucosa0.88417358
75MP0003806_abnormal_nucleotide_metabolis0.88383494
76MP0005253_abnormal_eye_physiology0.87786818
77MP0002752_abnormal_somatic_nervous0.85539065
78MP0003879_abnormal_hair_cell0.85200669
79MP0002090_abnormal_vision0.82432246
80MP0002249_abnormal_larynx_morphology0.80621568
81MP0002557_abnormal_social/conspecific_i0.80244329
82MP0001346_abnormal_lacrimal_gland0.79763307
83MP0003123_paternal_imprinting0.79455195
84MP0005084_abnormal_gallbladder_morpholo0.78415374
85MP0009333_abnormal_splenocyte_physiolog0.77708186
86MP0002572_abnormal_emotion/affect_behav0.76057452
87MP0008775_abnormal_heart_ventricle0.75617680
88MP0002928_abnormal_bile_duct0.73273676
89MP0000955_abnormal_spinal_cord0.72697478
90MP0005636_abnormal_mineral_homeostasis0.71304421
91MP0000230_abnormal_systemic_arterial0.68257084
92MP0002210_abnormal_sex_determination0.66514499
93MP0005174_abnormal_tail_pigmentation0.66376648
94MP0002733_abnormal_thermal_nociception0.66020340
95MP0003880_abnormal_central_pattern0.65249003
96MP0005645_abnormal_hypothalamus_physiol0.64915045
97MP0002148_abnormal_hypersensitivity_rea0.64164577
98MP0009053_abnormal_anal_canal0.64031817
99MP0000778_abnormal_nervous_system0.63398588
100MP0003252_abnormal_bile_duct0.62009810

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.74737565
2Acute necrotizing encephalopathy (HP:0006965)5.43313446
33-Methylglutaconic aciduria (HP:0003535)5.10706559
4Abnormal mitochondria in muscle tissue (HP:0008316)4.83300726
5Mitochondrial inheritance (HP:0001427)4.80210425
6Acute encephalopathy (HP:0006846)4.72976790
7Progressive macrocephaly (HP:0004481)4.42410679
8Abnormality of cells of the erythroid lineage (HP:0012130)4.29958681
9Increased CSF lactate (HP:0002490)4.28844222
10Hepatocellular necrosis (HP:0001404)3.92047191
11Macrocytic anemia (HP:0001972)3.77490486
12Cerebral edema (HP:0002181)3.45454535
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.41808647
14Congenital, generalized hypertrichosis (HP:0004540)3.35220667
15Pallor (HP:0000980)3.32752940
16Hepatic necrosis (HP:0002605)3.29470339
17Abnormal number of erythroid precursors (HP:0012131)3.20710074
18Congenital stationary night blindness (HP:0007642)3.16249815
19Testicular atrophy (HP:0000029)3.01231544
20Increased hepatocellular lipid droplets (HP:0006565)2.97956726
21Abnormal rod and cone electroretinograms (HP:0008323)2.97846796
22Pancreatic cysts (HP:0001737)2.94001339
23Supernumerary spleens (HP:0009799)2.92947701
24Abnormality of midbrain morphology (HP:0002418)2.91130991
25Molar tooth sign on MRI (HP:0002419)2.91130991
26Lipid accumulation in hepatocytes (HP:0006561)2.89894094
27Optic disc pallor (HP:0000543)2.88112870
28Pancreatic fibrosis (HP:0100732)2.87796633
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82535186
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82535186
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.79835577
32Leukodystrophy (HP:0002415)2.77515991
33Decreased central vision (HP:0007663)2.73367685
34Autoimmune thrombocytopenia (HP:0001973)2.72501849
35Respiratory failure (HP:0002878)2.70915530
36Colon cancer (HP:0003003)2.63400319
37Increased serum lactate (HP:0002151)2.62883976
38True hermaphroditism (HP:0010459)2.59498742
39Lactic acidosis (HP:0003128)2.59255919
40Medial flaring of the eyebrow (HP:0010747)2.58269096
41Absent thumb (HP:0009777)2.54881630
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.54848627
43Septo-optic dysplasia (HP:0100842)2.52594351
44Pendular nystagmus (HP:0012043)2.51670440
45Attenuation of retinal blood vessels (HP:0007843)2.47761001
46Asplenia (HP:0001746)2.46813723
47Myokymia (HP:0002411)2.46342951
48Hyperglycinemia (HP:0002154)2.37283492
49Autoimmune hemolytic anemia (HP:0001890)2.36552621
50Abnormality of B cell number (HP:0010975)2.36321154
51Abolished electroretinogram (ERG) (HP:0000550)2.35238439
52Abnormality of the renal cortex (HP:0011035)2.35152267
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33062974
54Increased intramyocellular lipid droplets (HP:0012240)2.32639615
55Renal Fanconi syndrome (HP:0001994)2.29178837
56Stenosis of the external auditory canal (HP:0000402)2.28608338
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27245805
58Adrenal hypoplasia (HP:0000835)2.20239468
59Nephronophthisis (HP:0000090)2.11426762
60Exercise intolerance (HP:0003546)2.09982887
61Abnormal hemoglobin (HP:0011902)2.09673258
62Abnormality of the renal medulla (HP:0100957)2.07662353
63Lethargy (HP:0001254)2.05465622
64Gait imbalance (HP:0002141)2.04095033
65Abnormality of magnesium homeostasis (HP:0004921)2.01025253
66Congenital primary aphakia (HP:0007707)2.00754864
67Exertional dyspnea (HP:0002875)2.00336251
68Maternal diabetes (HP:0009800)2.00267230
69Increased IgM level (HP:0003496)1.97187179
70Increased muscle lipid content (HP:0009058)1.96377631
71Sclerocornea (HP:0000647)1.96000823
72Postaxial foot polydactyly (HP:0001830)1.94851221
73Anencephaly (HP:0002323)1.92806080
74CNS demyelination (HP:0007305)1.89110300
75Methylmalonic acidemia (HP:0002912)1.88054103
76Cystic liver disease (HP:0006706)1.86928784
77Agitation (HP:0000713)1.85209634
78Abnormality of the labia minora (HP:0012880)1.84239006
79Hypomagnesemia (HP:0002917)1.82815747
80Abnormality of cochlea (HP:0000375)1.82307226
81Depressed nasal ridge (HP:0000457)1.82016439
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81584761
83Increased corneal curvature (HP:0100692)1.79963971
84Keratoconus (HP:0000563)1.79963971
85Male pseudohermaphroditism (HP:0000037)1.78245403
86X-linked dominant inheritance (HP:0001423)1.77478257
87Polydipsia (HP:0001959)1.75935831
88Abnormal drinking behavior (HP:0030082)1.75935831
89Nephrogenic diabetes insipidus (HP:0009806)1.75593988
90Neutropenia (HP:0001875)1.68436574
91Polyuria (HP:0000103)1.68365791
92Arthropathy (HP:0003040)1.68171069
93Abnormal respiratory motile cilium physiology (HP:0012261)1.66136656
94Focal motor seizures (HP:0011153)1.64606097
95Visual hallucinations (HP:0002367)1.63487152
96Limb dystonia (HP:0002451)1.63392823
97Abnormality of DNA repair (HP:0003254)1.62209004
98Growth hormone deficiency (HP:0000824)1.62154093
99Postaxial hand polydactyly (HP:0001162)1.62151055
100Absent septum pellucidum (HP:0001331)1.60980295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.12630488
2WNK42.97092110
3GRK12.83081339
4PINK12.73957305
5CDK192.70491519
6ADRBK22.48467298
7TLK12.39374742
8CAMKK22.34367657
9FRK2.31529197
10PASK2.24653983
11BMPR22.23428051
12BCKDK1.92556466
13NME21.91133910
14STK391.87629672
15TXK1.74482989
16CAMKK11.70245792
17PLK41.69869941
18MYLK1.65338964
19OXSR11.60067142
20CDC71.53425389
21TIE11.48782596
22FES1.46928355
23DYRK21.43398852
24MUSK1.39836774
25PIK3CA1.33818351
26ZAK1.31912763
27PLK21.25822060
28MAP4K21.25549059
29TAOK31.20474612
30STK161.18601274
31EPHA41.16609041
32MAP4K11.13663448
33ILK1.10213767
34MAP3K111.06082884
35LRRK21.05870023
36CAMK11.04555195
37DAPK31.02433567
38ADRBK11.02153560
39INSRR1.00444642
40AURKB1.00432082
41VRK20.99778252
42BUB10.99155670
43WNK30.98885607
44WNK10.95512287
45ABL20.92436004
46OBSCN0.91526162
47NUAK10.87977920
48BMPR1B0.82242210
49NME10.82113941
50PRKCG0.82006355
51MAP3K40.81683053
52KDR0.81396903
53PIK3CG0.80860192
54IKBKB0.80617403
55EPHB20.76144924
56CSNK2A20.74909384
57GRK60.71775216
58CAMK2A0.69455766
59PRKACA0.69245619
60DAPK20.68845217
61CSNK2A10.67274745
62VRK10.66680667
63CHEK20.66072399
64PHKG20.65430017
65PHKG10.65430017
66MAP2K70.64446008
67PLK10.63972421
68LYN0.62444377
69CSNK1G20.62290520
70AURKA0.61616490
71CSNK1G30.61557316
72ATR0.59982892
73TEC0.59642165
74NEK10.59560737
75PRKCE0.59122781
76RPS6KA50.58664697
77PRKCA0.58194175
78BTK0.56482928
79CASK0.53682455
80MAPK130.52971674
81ERBB30.52685161
82MARK30.52504475
83PRKCI0.51653146
84EIF2AK10.51410723
85PNCK0.51152992
86TRPM70.49991491
87ITK0.49621113
88CSNK1E0.48729566
89PRKCD0.48666734
90ERBB20.47577573
91ROCK10.47142104
92CSNK1A10.46531443
93MKNK20.46067177
94STK110.44547750
95LIMK10.44196142
96PRKCH0.44134976
97IGF1R0.43133327
98PRKCQ0.43083260
99CSNK1A1L0.41855466
100MAPK150.41302461

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.80817631
2Oxidative phosphorylation_Homo sapiens_hsa001904.94168630
3Parkinsons disease_Homo sapiens_hsa050124.17553659
4Alzheimers disease_Homo sapiens_hsa050103.04540342
5Huntingtons disease_Homo sapiens_hsa050162.88275358
6Cardiac muscle contraction_Homo sapiens_hsa042602.84839438
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.79069380
8Asthma_Homo sapiens_hsa053102.60311348
9Proteasome_Homo sapiens_hsa030502.57298017
10Protein export_Homo sapiens_hsa030602.42890642
11Homologous recombination_Homo sapiens_hsa034402.22400179
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17367941
13RNA polymerase_Homo sapiens_hsa030202.13874246
14One carbon pool by folate_Homo sapiens_hsa006701.84549235
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.77003088
16Phototransduction_Homo sapiens_hsa047441.67914105
17RNA degradation_Homo sapiens_hsa030181.59401789
18Allograft rejection_Homo sapiens_hsa053301.55452708
19Autoimmune thyroid disease_Homo sapiens_hsa053201.51815580
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51320120
21DNA replication_Homo sapiens_hsa030301.50286609
22Mismatch repair_Homo sapiens_hsa034301.44270128
23Linoleic acid metabolism_Homo sapiens_hsa005911.42154012
24Graft-versus-host disease_Homo sapiens_hsa053321.35179652
25Pyrimidine metabolism_Homo sapiens_hsa002401.33214795
26Type I diabetes mellitus_Homo sapiens_hsa049401.24486058
27Fanconi anemia pathway_Homo sapiens_hsa034601.21405948
28Nitrogen metabolism_Homo sapiens_hsa009101.19868243
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09766159
30Base excision repair_Homo sapiens_hsa034101.03308846
31Spliceosome_Homo sapiens_hsa030400.99104727
32Nucleotide excision repair_Homo sapiens_hsa034200.98615772
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89818912
34Fat digestion and absorption_Homo sapiens_hsa049750.87560331
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86444431
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82805133
37Chemical carcinogenesis_Homo sapiens_hsa052040.80255970
38Propanoate metabolism_Homo sapiens_hsa006400.79933640
39Caffeine metabolism_Homo sapiens_hsa002320.79559964
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78440136
41Olfactory transduction_Homo sapiens_hsa047400.77668743
42Purine metabolism_Homo sapiens_hsa002300.77250346
43Sulfur relay system_Homo sapiens_hsa041220.76160230
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72678780
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72392168
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71907498
47Metabolic pathways_Homo sapiens_hsa011000.70457431
48Nicotine addiction_Homo sapiens_hsa050330.68446596
49Ether lipid metabolism_Homo sapiens_hsa005650.67702629
50Retinol metabolism_Homo sapiens_hsa008300.67055580
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.66650185
52Tryptophan metabolism_Homo sapiens_hsa003800.65909668
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.65174803
54Arachidonic acid metabolism_Homo sapiens_hsa005900.63622155
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63404495
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63170030
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.61654101
58Antigen processing and presentation_Homo sapiens_hsa046120.58850980
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58226484
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56990156
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55651504
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.54876306
63beta-Alanine metabolism_Homo sapiens_hsa004100.54321118
64Peroxisome_Homo sapiens_hsa041460.53380807
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53147670
66Butanoate metabolism_Homo sapiens_hsa006500.52332150
67Hedgehog signaling pathway_Homo sapiens_hsa043400.52159682
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51676475
69Basal transcription factors_Homo sapiens_hsa030220.49938621
70Rheumatoid arthritis_Homo sapiens_hsa053230.49604880
71Systemic lupus erythematosus_Homo sapiens_hsa053220.48048304
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47270120
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46936906
74RNA transport_Homo sapiens_hsa030130.46631558
75Primary immunodeficiency_Homo sapiens_hsa053400.45386194
76Folate biosynthesis_Homo sapiens_hsa007900.43443030
77Fatty acid degradation_Homo sapiens_hsa000710.42690764
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41252000
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41185058
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41106328
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.35596287
82Basal cell carcinoma_Homo sapiens_hsa052170.33632512
83Morphine addiction_Homo sapiens_hsa050320.32983660
84Taste transduction_Homo sapiens_hsa047420.32486338
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32162876
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29228505
87Sulfur metabolism_Homo sapiens_hsa009200.29199072
88Insulin secretion_Homo sapiens_hsa049110.28622654
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28517436
90Viral myocarditis_Homo sapiens_hsa054160.28010223
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27523796
92Hematopoietic cell lineage_Homo sapiens_hsa046400.25882133
93Glycerolipid metabolism_Homo sapiens_hsa005610.25777343
94Pyruvate metabolism_Homo sapiens_hsa006200.25023907
95Tyrosine metabolism_Homo sapiens_hsa003500.25016863
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24576864
97Collecting duct acid secretion_Homo sapiens_hsa049660.24533979
98Glutathione metabolism_Homo sapiens_hsa004800.23295459
99Staphylococcus aureus infection_Homo sapiens_hsa051500.22769799
100Steroid biosynthesis_Homo sapiens_hsa001000.22323563

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